guanidine has been researched along with Disease Models, Animal in 21 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Structural features associated with the antimalarial activity of the marine natural product crambescidin 800 were studied using synthetic analogues of the related compound ptilomycalin A." | 7.73 | Antimalarial activity of crambescidin 800 and synthetic analogues against liver and blood stage of Plasmodium sp. ( Black, GP; Concepcion, GP; Diquet, B; Howard-Jones, AG; Ibana, JA; Ireland, CM; Lazaro, JE; Mahmoudi, N; Mangalindan, GC; Mazier, D; Moore, CG; Murphy, PJ; Nitcheu, J; Thomas, DA, 2006) |
| " The methylation of phosphatidylethanolamine to form choline has been extensively studied in the context of fatty liver disease." | 3.96 | Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice. ( da Silva, RP; Eudy, BJ; Fernandez, G; Lai, J; Mathews, CE; McDermott, CE, 2020) |
| "Structural features associated with the antimalarial activity of the marine natural product crambescidin 800 were studied using synthetic analogues of the related compound ptilomycalin A." | 3.73 | Antimalarial activity of crambescidin 800 and synthetic analogues against liver and blood stage of Plasmodium sp. ( Black, GP; Concepcion, GP; Diquet, B; Howard-Jones, AG; Ibana, JA; Ireland, CM; Lazaro, JE; Mahmoudi, N; Mangalindan, GC; Mazier, D; Moore, CG; Murphy, PJ; Nitcheu, J; Thomas, DA, 2006) |
| "Neonatal sepsis is defined as a systemic inflammatory response caused by a suspected or proven infection, occurring in the first month of life, and remains one of the main causes of morbidity and mortality in newborn and preterm infants." | 1.56 | Indole-3-guanylhydrazone hydrochloride mitigates long-term cognitive impairment in a neonatal sepsis model with involvement of MAPK and NFκB pathways. ( Araújo-Júnior, JX; Barreto, RSS; Bezerra Carvalho, MT; Bourguignon, JJ; Carvalho, AMS; da Silva-Júnior, EF; de Aquino, TM; Heimfarth, L; Lima, NT; Moreira, JCF; Pereira, EWM; Quintans, JSS; Quintans-Júnior, LJ; Schmitt, M, 2020) |
| "Importantly, viremia is prevented by early treatment with guanidine." | 1.51 | Evaluation of antiviral therapies in respiratory and neurological disease models of Enterovirus D68 infection in mice. ( Evans, WJ; Hurst, BL; Smee, DF; Tarbet, EB; Van Wettere, AJ, 2019) |
| " Thus, thiophene-diguanidino derivatives with improved bioavailability when administered orally could lead to treatment options against AE." | 1.39 | In vitro and in vivo activities of dicationic diguanidino compounds against Echinococcus multilocularis metacestodes. ( Boykin, DW; Hemphill, A; Kriegel, N; Küster, T; Stephens, CE, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 11 (52.38) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Qi, XJ | 1 |
| Liu, XY | 1 |
| Tang, LM | 1 |
| Li, PF | 1 |
| Qiu, F | 1 |
| Yang, AH | 1 |
| Heimfarth, L | 1 |
| Carvalho, AMS | 1 |
| Quintans, JSS | 1 |
| Pereira, EWM | 1 |
| Lima, NT | 1 |
| Bezerra Carvalho, MT | 1 |
| Barreto, RSS | 1 |
| Moreira, JCF | 1 |
| da Silva-Júnior, EF | 1 |
| Schmitt, M | 1 |
| Bourguignon, JJ | 1 |
| de Aquino, TM | 1 |
| Araújo-Júnior, JX | 1 |
| Quintans-Júnior, LJ | 1 |
| Eudy, BJ | 1 |
| McDermott, CE | 1 |
| Fernandez, G | 1 |
| Mathews, CE | 1 |
| Lai, J | 1 |
| da Silva, RP | 1 |
| Liu, Y | 1 |
| Song, M | 1 |
| Ding, S | 1 |
| Zhu, K | 1 |
| Hurst, BL | 1 |
| Evans, WJ | 1 |
| Smee, DF | 1 |
| Van Wettere, AJ | 1 |
| Tarbet, EB | 1 |
| Küster, T | 1 |
| Kriegel, N | 1 |
| Boykin, DW | 1 |
| Stephens, CE | 1 |
| Hemphill, A | 1 |
| Ribes, S | 1 |
| Meister, T | 1 |
| Ott, M | 1 |
| Redlich, S | 1 |
| Janova, H | 1 |
| Hanisch, UK | 1 |
| Nessler, S | 1 |
| Nau, R | 1 |
| Vargas, JR | 1 |
| Stanzl, EG | 1 |
| Teng, NN | 1 |
| Wender, PA | 1 |
| Stoyanova, A | 1 |
| Nikolova, I | 1 |
| Galabov, AS | 1 |
| Sheets, LP | 1 |
| Li, AA | 1 |
| Minnema, DJ | 1 |
| Collier, RH | 1 |
| Creek, MR | 1 |
| Peffer, RC | 1 |
| Morcos, PA | 2 |
| Li, Y | 1 |
| Jiang, S | 2 |
| Barsoum, AL | 1 |
| Liu, B | 1 |
| Rohrer, JW | 1 |
| Coggin, JH | 1 |
| Tucker, JA | 1 |
| Pannell, LK | 1 |
| Schwarzenberger, PO | 1 |
| Breitbach, K | 1 |
| Wongprompitak, P | 1 |
| Steinmetz, I | 1 |
| Widrick, JJ | 1 |
| Choi, SJ | 1 |
| Knuth, ST | 1 |
| Thomas, SM | 1 |
| Sahu, B | 1 |
| Rapireddy, S | 1 |
| Bahal, R | 1 |
| Wheeler, SE | 1 |
| Procopio, EM | 1 |
| Kim, J | 1 |
| Joyce, SC | 1 |
| Contrucci, S | 1 |
| Wang, Y | 1 |
| Chiosea, SI | 1 |
| Lathrop, KL | 1 |
| Watkins, S | 1 |
| Grandis, JR | 1 |
| Armitage, BA | 1 |
| Ly, DH | 1 |
| Ryu, JK | 1 |
| Choi, MJ | 1 |
| Kim, TI | 1 |
| Jin, HR | 1 |
| Kwon, KD | 1 |
| Batbold, D | 1 |
| Song, KM | 1 |
| Kwon, MH | 1 |
| Yin, GN | 1 |
| Lee, M | 1 |
| Kim, SW | 1 |
| Suh, JK | 1 |
| Hirsch-Reinshagen, V | 1 |
| Maia, LF | 1 |
| Burgess, BL | 1 |
| Blain, JF | 1 |
| Naus, KE | 1 |
| McIsaac, SA | 1 |
| Parkinson, PF | 1 |
| Chan, JY | 1 |
| Tansley, GH | 1 |
| Hayden, MR | 1 |
| Poirier, J | 1 |
| Van Nostrand, W | 1 |
| Wellington, CL | 1 |
| Lazaro, JE | 1 |
| Nitcheu, J | 1 |
| Mahmoudi, N | 1 |
| Ibana, JA | 1 |
| Mangalindan, GC | 1 |
| Black, GP | 1 |
| Howard-Jones, AG | 1 |
| Moore, CG | 1 |
| Thomas, DA | 1 |
| Mazier, D | 1 |
| Ireland, CM | 1 |
| Concepcion, GP | 1 |
| Murphy, PJ | 1 |
| Diquet, B | 1 |
| Manicourt, D | 1 |
| Howell, DS | 1 |
| Moskowitz, RW | 1 |
| Goldberg, V | 1 |
| Malemud, C | 1 |
| Pita, JC | 1 |
| Peyman, A | 1 |
| Scheunemann, K | 1 |
| Will, DW | 1 |
| Knolle, J | 1 |
| Wehner, V | 1 |
| Breipohl, G | 1 |
| Stilz, HU | 1 |
| Carniato, D | 1 |
| Ruxer, J | 1 |
| Gourvest, J | 1 |
| Auberval, M | 1 |
| Doucet, B | 1 |
| Baron, R | 1 |
| Gaillard, M | 1 |
| Gadek, TR | 1 |
| Bodary, S | 1 |
| Goto, I | 1 |
| Nagara, H | 1 |
| Tateishi, J | 1 |
| Kuroiwa, Y | 1 |
2 reviews available for guanidine and Disease Models, Animal
| Article | Year |
|---|---|
Cell-penetrating, guanidinium-rich molecular transporters for overcoming efflux-mediated multidrug resistance.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, T | 2014 |
A critical review of neonicotinoid insecticides for developmental neurotoxicity.
Topics: Animals; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Guanidine | 2016 |
19 other studies available for guanidine and Disease Models, Animal
| Article | Year |
|---|---|
Anti-depressant effect of curcumin-loaded guanidine-chitosan thermo-sensitive hydrogel by nasal delivery.
Topics: Administration, Intranasal; Animals; Antidepressive Agents; Chitosan; Curcumin; Depression; Disease | 2020 |
Indole-3-guanylhydrazone hydrochloride mitigates long-term cognitive impairment in a neonatal sepsis model with involvement of MAPK and NFκB pathways.
Topics: Animals; Anti-Inflammatory Agents; Cognitive Dysfunction; Disease Models, Animal; Female; Guanidine; | 2020 |
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice.
Topics: Adenosine; Animals; Carbon; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; | 2020 |
Discovery of Linear Low-Cationic Peptides to Target Methicillin-Resistant Staphylococcus aureus in Vivo.
Topics: Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Chlorocebus aethiops; Disease Model | 2019 |
Evaluation of antiviral therapies in respiratory and neurological disease models of Enterovirus D68 infection in mice.
Topics: Animals; Antiviral Agents; Cytokines; Disease Models, Animal; Enterovirus D, Human; Enterovirus Infe | 2019 |
In vitro and in vivo activities of dicationic diguanidino compounds against Echinococcus multilocularis metacestodes.
Topics: Animals; Anticestodal Agents; Cells, Cultured; Chlorocebus aethiops; Disease Models, Animal; Drug Ev | 2013 |
Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection.
Topics: Animals; Antigens, CD; Central Nervous System; Cytokines; Disease Models, Animal; Drug Administratio | 2014 |
Effect of consecutive alternating administration (CAA) of a triple anti-enteroviral combination on Coxsackievirus B1 neuroinfection in mice.
Topics: Animals; Antiviral Agents; Apomorphine; Brain; Central Nervous System Infections; Coxsackievirus Inf | 2015 |
Vivo-Morpholinos: a non-peptide transporter delivers Morpholinos into a wide array of mouse tissues.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Drug Delivery Systems; Dystrophin; Fluorescent Ant | 2008 |
Production, safety and antitumor efficacy of recombinant Oncofetal Antigen/immature laminin receptor protein.
Topics: Amino Acid Sequence; Animals; Antigens, Neoplasm; Cancer Vaccines; Cell Line, Tumor; Clinical Trials | 2009 |
Distinct roles for nitric oxide in resistant C57BL/6 and susceptible BALB/c mice to control Burkholderia pseudomallei infection.
Topics: Animals; Burkholderia pseudomallei; Cells, Cultured; Cytotoxicity, Immunologic; Disease Models, Anim | 2011 |
An octaguanidine-morpholino oligo conjugate improves muscle function of mdx mice.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dystrophin; Electric Stimulation; Gene Expres | 2011 |
Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, | 2013 |
A guanidinylated bioreducible polymer as a novel gene carrier to the corpus cavernosum of mice with high-cholesterol diet-induced erectile dysfunction.
Topics: Animals; Cell Line; Cells, Cultured; Cholesterol, Dietary; Disease Models, Animal; Endothelial Cells | 2013 |
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid; Animals; Apolipoproteins E; ATP Binding Cassette Transporter 1; ATP-Bind | 2005 |
Antimalarial activity of crambescidin 800 and synthetic analogues against liver and blood stage of Plasmodium sp.
Topics: Animals; Antimalarials; Cells, Cultured; Disease Models, Animal; Erythrocytes; Guanidine; Hepatocyte | 2006 |
Application of new techniques to separation of proteoglycan aggregates from normal and destabilized rabbit articular cartilages.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Guanidine; Guanidines; Macromolecular Substan | 1984 |
alpha(v)beta(3) Antagonists based on a central thiophene scaffold.
Topics: Animals; Binding Sites; Carbamates; Cell Adhesion; Cells, Cultured; Disease Models, Animal; Dose-Res | 2001 |
Thiamine-deficient encephalopathy in rats: effects of deficiencies of thiamine and magnesium.
Topics: Animals; Body Weight; Brain; Brain Diseases, Metabolic; Brain Edema; Disease Models, Animal; Guanidi | 1986 |