guanidine has been researched along with Dementias, Transmissible in 10 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Transmissible spongiform encephalopathies are associated with accumulation of PrP(Sc), a conformer of a cellular protein called PrP(C)." | 1.31 | Binding of disease-associated prion protein to plasminogen. ( Aguzzi, A; Fischer, MB; Parizek, P; Roeckl, C; Schwarz, HP, 2000) |
| "These data demonstrate that loss of scrapie infectivity can be a reversible process and that copper can enhance this restoration of proteinase K resistance and infectivity." | 1.30 | Reversibility of scrapie inactivation is enhanced by copper. ( Aiken, J; Bartz, J; Marsh, R; McKenzie, D; Mirwald, J; Olander, D, 1998) |
| "Hereditary forms of human prion disease are linked to specific mutations in the PRNP gene." | 1.30 | Familial mutations and the thermodynamic stability of the recombinant human prion protein. ( Gambetti, P; Petersen, RB; Surewicz, WK; Swietnicki, W, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bian, J | 1 |
| Khaychuk, V | 1 |
| Angers, RC | 1 |
| Fernández-Borges, N | 1 |
| Vidal, E | 1 |
| Meyerett-Reid, C | 1 |
| Kim, S | 1 |
| Calvi, CL | 1 |
| Bartz, JC | 1 |
| Hoover, EA | 1 |
| Agrimi, U | 1 |
| Richt, JA | 1 |
| Castilla, J | 1 |
| Telling, GC | 1 |
| Shindoh, R | 1 |
| Kim, CL | 1 |
| Song, CH | 1 |
| Hasebe, R | 1 |
| Horiuchi, M | 2 |
| Kang, SC | 1 |
| Li, R | 1 |
| Wang, C | 1 |
| Pan, T | 1 |
| Liu, T | 1 |
| Rubenstein, R | 1 |
| Barnard, G | 2 |
| Wong, BS | 1 |
| Sy, MS | 1 |
| Dabaghian, RH | 1 |
| McConnell, I | 1 |
| Clewley, JP | 1 |
| Mazhul', VM | 1 |
| Zaĭtseva, EM | 1 |
| Shavlovskiĭ, MM | 1 |
| Povarova, OI | 1 |
| Kuznetsova, IM | 1 |
| Turoverov, KK | 1 |
| Bessen, RA | 1 |
| Kocisko, DA | 1 |
| Raymond, GJ | 2 |
| Nandan, S | 1 |
| Lansbury, PT | 1 |
| Caughey, B | 2 |
| McKenzie, D | 1 |
| Bartz, J | 1 |
| Mirwald, J | 1 |
| Olander, D | 1 |
| Marsh, R | 1 |
| Aiken, J | 1 |
| Swietnicki, W | 1 |
| Petersen, RB | 1 |
| Gambetti, P | 1 |
| Surewicz, WK | 1 |
| Demaimay, R | 1 |
| Fischer, MB | 1 |
| Roeckl, C | 1 |
| Parizek, P | 1 |
| Schwarz, HP | 1 |
| Aguzzi, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of the Coagulation Pathway at the Synapse in Prion Diseases[NCT02480725] | 50 participants (Anticipated) | Observational | 2015-06-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 other studies available for guanidine and Dementias, Transmissible
| Article | Year |
|---|---|
Prion replication without host adaptation during interspecies transmissions.
Topics: Animals; Deer; Guanidine; Horses; Host Specificity; Mice; Mice, Inbred C57BL; Prion Diseases; Prions | 2017 |
The region approximately between amino acids 81 and 137 of proteinase K-resistant PrPSc is critical for the infectivity of the Chandler prion strain.
Topics: Amino Acids; Animals; Endopeptidase K; Guanidine; Mice; Prion Diseases; Protein Conformation; Protei | 2009 |
Guanidine hydrochloride extraction and detection of prion proteins in mouse and hamster prion diseases by ELISA.
Topics: Animals; Antibodies, Monoclonal; Brain Chemistry; Cricetinae; Enzyme-Linked Immunosorbent Assay; Gua | 2003 |
An immunoassay for the pathological form of the prion protein based on denaturation and time resolved fluorometry.
Topics: Brain; Brain Chemistry; Creutzfeldt-Jakob Syndrome; Fluorescent Antibody Technique; Fluorometry; Gua | 2006 |
[Room temperature phosphorescence of amorphous aggregates and amyloid fibrils resulting from protein misfolding].
Topics: Actins; Amyloid; Amyloidosis; Animals; Cattle; Guanidine; Insulin; Kinetics; Lactalbumin; Luminescen | 2005 |
Non-genetic propagation of strain-specific properties of scrapie prion protein.
Topics: Animals; Cetylpyridinium; Cricetinae; Culture Techniques; Endopeptidase K; Guanidine; Guanidines; Me | 1995 |
Reversibility of scrapie inactivation is enhanced by copper.
Topics: Animals; Brain; Copper; Cricetinae; Endopeptidase K; Guanidine; Mesocricetus; Prion Diseases; Protei | 1998 |
Familial mutations and the thermodynamic stability of the recombinant human prion protein.
Topics: Creutzfeldt-Jakob Syndrome; Gerstmann-Straussler-Scheinker Disease; Guanidine; Hot Temperature; Huma | 1998 |
Assays of protease-resistant prion protein and its formation.
Topics: Animals; Brain; Cell-Free System; Cells, Cultured; Endopeptidases; Guanidine; Humans; Immunoblotting | 1999 |
Binding of disease-associated prion protein to plasminogen.
Topics: Animals; Blotting, Western; Guanidine; Humans; Magnetics; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2000 |