guanidine has been researched along with Cystic Fibrosis in 5 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Guanidine hydrochloride acts as a classical electrolyte in the reversible suppression of charge effects, and not as a denaturing or dissociation agent." | 1.27 | Polyelectrolyte behaviour in mucus glycoproteins. ( Creeth, JM; Harding, SE, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yavin, E | 1 |
| Slayter, HS | 1 |
| Lamblin, G | 1 |
| Le Treut, A | 1 |
| Galabert, C | 1 |
| Houdret, N | 1 |
| Degand, P | 1 |
| Roussel, P | 1 |
| Harding, SE | 1 |
| Creeth, JM | 1 |
| Devaraj, N | 1 |
| Devaraj, H | 1 |
| Bhavanandan, VP | 1 |
| Chace, KV | 1 |
| Naziruddin, B | 1 |
| Desai, VC | 1 |
| Flux, M | 1 |
| Sachdev, GP | 1 |
5 other studies available for guanidine and Cystic Fibrosis
| Article | Year |
|---|---|
Peptide Nucleic Acids: Applications in Biomedical Sciences.
Topics: Anti-Bacterial Agents; Antimalarials; Antiviral Agents; Biomimetic Materials; Cell Membrane Permeabi | 2020 |
Complex structure of human bronchial mucus glycoprotein.
Topics: Amino Acids; Bronchi; Bronchitis; Carbohydrates; Chemical Phenomena; Chemistry, Physical; Child; Chr | 1984 |
Polyelectrolyte behaviour in mucus glycoproteins.
Topics: Cystic Fibrosis; Female; Glycoproteins; Guanidine; Guanidines; Humans; Molecular Weight; Mucus; Osmo | 1983 |
Purification of mucin glycoproteins by density gradient centrifugation in cesium trifluoroacetate.
Topics: Animals; Bromides; Bronchi; Cattle; Centrifugation, Density Gradient; Cesium; Cystic Fibrosis; DNA; | 1992 |
Physical properties of purified human respiratory mucus glycoproteins: effects of sodium chloride concentration on the aggregation properties and shape.
Topics: Adolescent; Adult; Amino Acids; Carbohydrates; Child; Cystic Fibrosis; Female; Guanidine; Guanidines | 1989 |