guanidine has been researched along with Choline Deficiency in 1 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The methylation of phosphatidylethanolamine to form choline has been extensively studied in the context of fatty liver disease." | 3.96 | Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice. ( da Silva, RP; Eudy, BJ; Fernandez, G; Lai, J; Mathews, CE; McDermott, CE, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eudy, BJ | 1 |
| McDermott, CE | 1 |
| Fernandez, G | 1 |
| Mathews, CE | 1 |
| Lai, J | 1 |
| da Silva, RP | 1 |
1 other study available for guanidine and Choline Deficiency
| Article | Year |
|---|---|
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice.
Topics: Adenosine; Animals; Carbon; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; | 2020 |