guanidine has been researched along with Cataract in 7 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cataract is a lens opacification disease prevalent worldwide." | 1.42 | Congenital Cataract-Causing Mutation G129C in γC-Crystallin Promotes the Accumulation of Two Distinct Unfolding Intermediates That Form Highly Toxic Aggregates. ( Chen, XJ; Xi, YB; Yan, YB; Zhao, WJ, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, H | 2 |
| Tian, Q | 1 |
| Xu, J | 3 |
| Xu, W | 1 |
| Yao, K | 2 |
| Chen, X | 2 |
| Wu, C | 1 |
| Wang, A | 1 |
| Wu, W | 1 |
| Luo, C | 1 |
| Ni, S | 1 |
| Xi, YB | 1 |
| Chen, XJ | 1 |
| Zhao, WJ | 1 |
| Yan, YB | 2 |
| Ma, Z | 1 |
| Piszczek, G | 1 |
| Wingfield, PT | 1 |
| Sergeev, YV | 1 |
| Hejtmancik, JF | 1 |
| Pang, M | 1 |
| Su, JT | 1 |
| Feng, S | 1 |
| Tang, ZW | 1 |
| Gu, F | 1 |
| Zhang, M | 1 |
| Ma, X | 1 |
| Meehan, S | 1 |
| Berry, Y | 1 |
| Luisi, B | 1 |
| Dobson, CM | 1 |
| Carver, JA | 1 |
| MacPhee, CE | 1 |
| Evans, P | 1 |
| Wyatt, K | 1 |
| Wistow, GJ | 1 |
| Bateman, OA | 1 |
| Wallace, BA | 1 |
| Slingsby, C | 1 |
7 other studies available for guanidine and Cataract
| Article | Year |
|---|---|
Cataract-causing G91del mutant destabilised βA3 heteromers formation linking with structural stability and cellular viability.
Topics: beta-Crystallin A Chain; Cataract; Crystallins; Glycine; Guanidine; Humans; Lens, Crystalline | 2022 |
Pathogenic mechanism of congenital cataract caused by the CRYBA1/A3-G91del variant and related intervention strategies.
Topics: Apoptosis; beta-Crystallin A Chain; Cataract; Cell Line; Genetic Predisposition to Disease; Guanidin | 2021 |
Congenital Cataract-Causing Mutation G129C in γC-Crystallin Promotes the Accumulation of Two Distinct Unfolding Intermediates That Form Highly Toxic Aggregates.
Topics: Amyloid; Apoptosis; Cataract; Cell Line, Tumor; Cell Proliferation; gamma-Crystallins; Guanidine; He | 2015 |
The G18V CRYGS mutation associated with human cataracts increases gammaS-crystallin sensitivity to thermal and chemical stress.
Topics: Cataract; Circular Dichroism; gamma-Crystallins; Guanidine; Hot Temperature; Humans; Lens, Crystalli | 2009 |
Effects of congenital cataract mutation R116H on alphaA-crystallin structure, function and stability.
Topics: Amino Acid Substitution; Cataract; Circular Dichroism; Crystallins; Guanidine; Humans; In Vitro Tech | 2010 |
Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation.
Topics: Aging; alpha-Crystallins; Amyloid; Animals; Benzothiazoles; beta-Crystallins; Cataract; Cattle; Dose | 2004 |
The P23T cataract mutation causes loss of solubility of folded gammaD-crystallin.
Topics: Amino Acid Sequence; Animals; Cataract; Circular Dichroism; gamma-Crystallins; Guanidine; Humans; Mo | 2004 |