guanidine has been researched along with CJD (Creutzfeldt-Jakob Disease) in 4 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neurodegenerative human CJD and sheep scrapie are diseases caused by several different transmissible encephalopathy (TSE) agents." | 1.42 | Rapid chemical decontamination of infectious CJD and scrapie particles parallels treatments known to disrupt microbes and biofilms. ( Botsios, S; Manuelidis, L; Tittman, S, 2015) |
| "Hereditary forms of human prion disease are linked to specific mutations in the PRNP gene." | 1.30 | Familial mutations and the thermodynamic stability of the recombinant human prion protein. ( Gambetti, P; Petersen, RB; Surewicz, WK; Swietnicki, W, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Botsios, S | 1 |
| Tittman, S | 1 |
| Manuelidis, L | 1 |
| Zou, WQ | 1 |
| Cashman, NR | 1 |
| Dabaghian, RH | 1 |
| Barnard, G | 1 |
| McConnell, I | 1 |
| Clewley, JP | 1 |
| Swietnicki, W | 1 |
| Petersen, RB | 1 |
| Gambetti, P | 1 |
| Surewicz, WK | 1 |
4 other studies available for guanidine and CJD (Creutzfeldt-Jakob Disease)
| Article | Year |
|---|---|
Rapid chemical decontamination of infectious CJD and scrapie particles parallels treatments known to disrupt microbes and biofilms.
Topics: Amyloid; Animals; Biofilms; Cell Line; Creutzfeldt-Jakob Syndrome; Decontamination; Detergents; Guan | 2015 |
Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form.
Topics: Antibodies, Monoclonal; Brain; Creutzfeldt-Jakob Syndrome; Detergents; Dose-Response Relationship, D | 2002 |
An immunoassay for the pathological form of the prion protein based on denaturation and time resolved fluorometry.
Topics: Brain; Brain Chemistry; Creutzfeldt-Jakob Syndrome; Fluorescent Antibody Technique; Fluorometry; Gua | 2006 |
Familial mutations and the thermodynamic stability of the recombinant human prion protein.
Topics: Creutzfeldt-Jakob Syndrome; Gerstmann-Straussler-Scheinker Disease; Guanidine; Hot Temperature; Huma | 1998 |