guanidine has been researched along with Amyotrophic Lateral Sclerosis in 4 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mulligan, VK | 1 |
| Kerman, A | 1 |
| Ho, S | 1 |
| Chakrabartty, A | 1 |
| Rumfeldt, JA | 2 |
| Lepock, JR | 2 |
| Meiering, EM | 2 |
| Stathopulos, PB | 1 |
| Chakrabarrty, A | 1 |
| Ono, S | 1 |
| Yamauchi, M | 1 |
4 other studies available for guanidine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Denaturational stress induces formation of zinc-deficient monomers of Cu,Zn superoxide dismutase: implications for pathogenesis in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Copper; Dimerization; Guanidine; Humans; Kinetics; Models, Molecular; | 2008 |
Unfolding and folding kinetics of amyotrophic lateral sclerosis-associated mutant Cu,Zn superoxide dismutases.
Topics: Amyotrophic Lateral Sclerosis; Apoproteins; Copper; Enzyme Stability; Guanidine; Humans; Hydrogen-Io | 2009 |
Mechanism and thermodynamics of guanidinium chloride-induced denaturation of ALS-associated mutant Cu,Zn superoxide dismutases.
Topics: Amyotrophic Lateral Sclerosis; Dose-Response Relationship, Drug; Guanidine; Humans; Kinetics; Mutati | 2006 |
Amyotrophic lateral sclerosis: increased solubility of skin collagen.
Topics: Amyotrophic Lateral Sclerosis; Collagen; Cyanogen Bromide; Guanidine; Guanidines; Humans; Hydrochlor | 1992 |