guanidine has been researched along with Acute Confusional Senile Dementia in 18 studies
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
guanidine : An aminocarboxamidine, the parent compound of the guanidines.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Clinical studies of SI showed promising benefits on mild to moderate AD, however, with limitations on dosage regime." | 1.46 | A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer's phenotypes. ( Chung, SK; Das, S; Jung, HY; Kim, KT; Kim, YK; Lee, D; Lee, J; Lee, WS; Lim, S; Luo, W, 2017) |
| "Dephosphorylation of Alzheimer's disease brain sections with alkaline phosphatase or denaturation with guanidine only causes a subtle reduction in the induced fluorescence of neurofibrillary tangles, while hydrofluoric acid or formic acid completely eliminates the fluorescence." | 1.33 | Biophysical and biochemical characterization of the intrinsic fluorescence from neurofibrillary tangles. ( Bing, G; Liu, M; Markesbery, WR; Nguyen, XV; Sun, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 5 (27.78) | 2.80 |
| Authors | Studies |
|---|---|
| Gehlot, P | 1 |
| Kumar, S | 1 |
| Kumar Vyas, V | 1 |
| Singh Choudhary, B | 1 |
| Sharma, M | 1 |
| Malik, R | 1 |
| Ali, S | 4 |
| Hassan Bin Asad, MH | 3 |
| Javed, MA | 3 |
| Javed, T | 3 |
| Al-Kharaman, YM | 3 |
| Latif, M | 3 |
| Mohsin, S | 3 |
| Nawaz, T | 3 |
| Farid Hasan, SM | 3 |
| Iqbal, J | 4 |
| Babak, B | 4 |
| Hussain, I | 4 |
| Ferrari, L | 1 |
| Stucchi, R | 1 |
| Konstantoulea, K | 1 |
| van de Kamp, G | 1 |
| Kos, R | 1 |
| Geerts, WJC | 1 |
| van Bezouwen, LS | 1 |
| Förster, FG | 1 |
| Altelaar, M | 1 |
| Hoogenraad, CC | 1 |
| Rüdiger, SGD | 1 |
| Asad, MHHB | 1 |
| Khan, F | 1 |
| Murtaza, G | 1 |
| Rizvanov, AA | 1 |
| Wongrattanakamon, P | 1 |
| Jiaranaikulwanitch, J | 1 |
| Vajragupta, O | 1 |
| Jiranusornkul, S | 1 |
| Saenjum, C | 1 |
| Yooin, W | 1 |
| Lee, D | 1 |
| Lee, WS | 1 |
| Lim, S | 1 |
| Kim, YK | 1 |
| Jung, HY | 1 |
| Das, S | 1 |
| Lee, J | 1 |
| Luo, W | 1 |
| Kim, KT | 1 |
| Chung, SK | 1 |
| Kim, H | 1 |
| Lee, JU | 1 |
| Kim, S | 1 |
| Song, S | 1 |
| Sim, SJ | 1 |
| Roos, K | 1 |
| Viklund, J | 1 |
| Meuller, J | 1 |
| Kaspersson, K | 1 |
| Svensson, M | 1 |
| Korecka, M | 1 |
| Waligorska, T | 1 |
| Figurski, M | 1 |
| Toledo, JB | 1 |
| Arnold, SE | 1 |
| Grossman, M | 1 |
| Trojanowski, JQ | 1 |
| Shaw, LM | 1 |
| Jeganathan, S | 1 |
| Hascher, A | 1 |
| Chinnathambi, S | 1 |
| Biernat, J | 1 |
| Mandelkow, EM | 1 |
| Mandelkow, E | 1 |
| Otzen, DE | 1 |
| Miron, S | 1 |
| Akke, M | 1 |
| Oliveberg, M | 1 |
| Bing, G | 1 |
| Nguyen, XV | 1 |
| Liu, M | 1 |
| Markesbery, WR | 1 |
| Sun, A | 1 |
| Hirsch-Reinshagen, V | 1 |
| Maia, LF | 1 |
| Burgess, BL | 1 |
| Blain, JF | 1 |
| Naus, KE | 1 |
| McIsaac, SA | 1 |
| Parkinson, PF | 1 |
| Chan, JY | 1 |
| Tansley, GH | 1 |
| Hayden, MR | 1 |
| Poirier, J | 1 |
| Van Nostrand, W | 1 |
| Wellington, CL | 1 |
| Jennings, LD | 1 |
| Cole, DC | 1 |
| Stock, JR | 1 |
| Sukhdeo, MN | 1 |
| Ellingboe, JW | 1 |
| Cowling, R | 1 |
| Jin, G | 1 |
| Manas, ES | 1 |
| Fan, KY | 1 |
| Malamas, MS | 1 |
| Harrison, BL | 1 |
| Jacobsen, S | 1 |
| Chopra, R | 1 |
| Lohse, PA | 1 |
| Moore, WJ | 1 |
| O'Donnell, MM | 1 |
| Hu, Y | 1 |
| Robichaud, AJ | 1 |
| Turner, MJ | 1 |
| Wagner, E | 1 |
| Bard, J | 1 |
| Anderton, B | 1 |
| Smith, MA | 1 |
| Siedlak, SL | 1 |
| Richey, PL | 1 |
| Nagaraj, RH | 1 |
| Elhammer, A | 1 |
| Perry, G | 1 |
| Yang, LS | 1 |
| Gordon-Krajcer, W | 1 |
| Ksiezak-Reding, H | 1 |
| Morishima-Kawashima, M | 1 |
| Oshima, N | 1 |
| Ogata, H | 1 |
| Yamaguchi, H | 1 |
| Yoshimura, M | 1 |
| Sugihara, S | 1 |
| Ihara, Y | 1 |
1 review available for guanidine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Guanidine-based β amyloid precursor protein cleavage enzyme 1 (BACE-1) inhibitors for the Alzheimer's disease (AD): A review.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2022 |
17 other studies available for guanidine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
A novel synthetic derivative of biaryl guanidine as a potential BACE1 inhibitor, to treat Alzheimer's disease: In-silico, in-vitro and in-vivo evaluation.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Guanidine; Gu | 2022 |
A novel synthetic derivative of biaryl guanidine as a potential BACE1 inhibitor, to treat Alzheimer's disease: In-silico, in-vitro and in-vivo evaluation.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Guanidine; Gu | 2022 |
A novel synthetic derivative of biaryl guanidine as a potential BACE1 inhibitor, to treat Alzheimer's disease: In-silico, in-vitro and in-vivo evaluation.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Guanidine; Gu | 2022 |
A novel synthetic derivative of biaryl guanidine as a potential BACE1 inhibitor, to treat Alzheimer's disease: In-silico, in-vitro and in-vivo evaluation.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Guanidine; Gu | 2022 |
Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Arginine; Disease Progression; Guanidine; | 2020 |
Biological Evaluation of Newly Synthesized Biaryl Guanidine Derivatives to Arrest
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Behavior, Animal; Brain; Guanidine | 2020 |
Potential Anti-Alzheimer Agents from Guanidinyl Tryptophan Derivatives with Activities of Membrane Adhesion and Conformational Transition Inhibitions.
Topics: Adhesiveness; Adsorption; Alzheimer Disease; Amyloid beta-Peptides; Cell Membrane; Guanidine; Humans | 2021 |
A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer's phenotypes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Brain; Cognition; Gliosis; G | 2017 |
A Nanoplasmonic Biosensor for Ultrasensitive Detection of Alzheimer's Disease Biomarker Using a Chaotropic Agent.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Female; Guanidine; Humans; Hydrogen Bond | 2019 |
Potency prediction of β-secretase (BACE-1) inhibitors using density functional methods.
Topics: Alzheimer Disease; Amidines; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Com | 2014 |
Qualification of a surrogate matrix-based absolute quantification method for amyloid-β₄₂ in human cerebrospinal fluid using 2D UPLC-tandem mass spectrometry.
Topics: Acetonitriles; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; | 2014 |
Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation.
Topics: Alzheimer Disease; Antibodies; Circular Dichroism; Epitopes; Guanidine; Microscopy, Electron, Transm | 2008 |
Transient aggregation and stable dimerization induced by introducing an Alzheimer sequence into a water-soluble protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Anilino Naphthalenesulfonates; Dimeri | 2004 |
Biophysical and biochemical characterization of the intrinsic fluorescence from neurofibrillary tangles.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain; Fluorescence; Guanidine; Humans; Immunoh | 2006 |
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid; Animals; Apolipoproteins E; ATP Binding Cassette Transporter 1; ATP-Bind | 2005 |
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; CHO Cells; Cricetinae; Cricetulus; | 2008 |
Untangling insoluble filaments.
Topics: Acyltransferases; Alzheimer Disease; Dementia; Guanidine; Guanidines; Humans; Neurofibrils; Octoxyno | 1983 |
Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alkalies; Alzheimer Disease; Cell Fractionation; Cross-L | 1996 |
Tau released from paired helical filaments with formic acid or guanidine is susceptible to calpain-mediated proteolysis.
Topics: Aged; Alzheimer Disease; Brain; Calpain; Female; Fetus; Formates; Guanidine; Humans; Immunohistochem | 1997 |
Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alleles; Alzheimer Disease; Amyloid beta-Peptides; Apolipopro | 2000 |