guanfacine has been researched along with Seizures in 6 studies
Guanfacine: A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs." | 2.49 | Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. ( Banaschewski, T; Buitelaar, J; Coghill, D; Cortese, S; Danckaerts, M; Dittmann, RW; Graham, J; Holtmann, M; Sergeant, J; Taylor, E, 2013) |
| "Following 6 stage-5 once daily convulsive seizures, guanfacine or idazoxan were re-administered." | 1.34 | Differential noradrenergic influence on seizure expression in genetically Fast and Slow kindling rat strains during massed trial stimulation of the amygdala. ( McIntyre, DC; Shin, RS, 2007) |
| " The principal pharmacokinetic parameters of guanfacine were greatly altered, with extended biotransformation and a decrease in the half-life compared to the values observed in other cases of severe renal insufficiency." | 1.27 | Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure. ( Comoy, E; Fillastre, JP; Godin, M; Guerret, M; Kiechel, JR; Lavene, D, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cortese, S | 1 |
| Holtmann, M | 1 |
| Banaschewski, T | 1 |
| Buitelaar, J | 1 |
| Coghill, D | 1 |
| Danckaerts, M | 1 |
| Dittmann, RW | 1 |
| Graham, J | 1 |
| Taylor, E | 1 |
| Sergeant, J | 1 |
| Szot, P | 1 |
| Lester, M | 1 |
| Laughlin, ML | 1 |
| Palmiter, RD | 1 |
| Liles, LC | 1 |
| Weinshenker, D | 1 |
| Shin, RS | 1 |
| McIntyre, DC | 1 |
| De Ocampo, AC | 1 |
| Jacobs, JM | 1 |
| Kiechel, JR | 1 |
| Lavene, D | 1 |
| Guerret, M | 1 |
| Comoy, E | 1 |
| Godin, M | 1 |
| Fillastre, JP | 1 |
| Kunchandy, J | 1 |
| Kulkarni, SK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.[NCT06069323] | 80 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for guanfacine and Seizures
| Article | Year |
|---|---|
Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents.
Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Blood Pressure | 2013 |
Medical management of autism.
Topics: Adolescent; Adult; Antidepressive Agents; Autistic Disorder; Central Nervous System Stimulants; Chil | 2006 |
4 other studies available for guanfacine and Seizures
| Article | Year |
|---|---|
The anticonvulsant and proconvulsant effects of alpha2-adrenoreceptor agonists are mediated by distinct populations of alpha2A-adrenoreceptors.
Topics: Adrenergic alpha-Agonists; Animals; Anticonvulsants; Autoreceptors; Clonidine; Convulsants; Guanfaci | 2004 |
Differential noradrenergic influence on seizure expression in genetically Fast and Slow kindling rat strains during massed trial stimulation of the amygdala.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amygdala; Analysis of Variance; Animals; Do | 2007 |
Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure.
Topics: Female; Guanfacine; Guanidines; Humans; Hypertension; Kidney Failure, Chronic; Kinetics; Middle Aged | 1983 |
Modulatory effect of alpha 2 adrenoceptor agonists on Ro 5-4864-induced convulsions in rats and mice.
Topics: Animals; Anticonvulsants; Azepines; Benzodiazepinones; Brain; Clonidine; Convulsants; Guanfacine; Gu | 1987 |