guanfacine and Drug Withdrawal Symptoms
guanfacine has been researched along with Drug Withdrawal Symptoms in 35 studies
Guanfacine: A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Guanfacine, an alpha 2-adrenoceptor agonist, was compared with clonidine as step-2 therapy of mild to moderate essential hypertension in a 24-week, double-blind, randomized, parallel evaluation to determine efficacy, safety and occurrence of withdrawal syndrome." | 9.06 | Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertension. ( Bedsole, G; Fillingim, J; Hall, D; Haring, O; Jagger, P; Lewin, A; McMahon, FG; Roginsky, M; Stepansky, W; Wilson, MF, 1986) |
" One group of animals received the norepinephrine α-2 agonist, guanfacine, or vehicle prior to anxiety testing 48 h after the last self-administration session." | 7.78 | Treatment of cocaine withdrawal anxiety with guanfacine: relationships to cocaine intake and reinstatement of cocaine seeking in rats. ( Baldwin, CK; Buffalari, DM; See, RE, 2012) |
"Guanfacine, an alpha 2-adrenoceptor agonist, was compared with clonidine as step-2 therapy of mild to moderate essential hypertension in a 24-week, double-blind, randomized, parallel evaluation to determine efficacy, safety and occurrence of withdrawal syndrome." | 5.06 | Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertension. ( Bedsole, G; Fillingim, J; Hall, D; Haring, O; Jagger, P; Lewin, A; McMahon, FG; Roginsky, M; Stepansky, W; Wilson, MF, 1986) |
" A comparison of its anti-hypertensive effect with that of methyldopa was made in patients with essential hypertension." | 5.05 | The antihypertensive effect of guanfacine compared with methyldopa. ( Kruger, SA; van der Merwe, CJ, 1980) |
" Twenty patients with essential hypertension were treated with guanfacine given in single daily doses of 1--5 mg over a period of 24 weeks." | 5.05 | Antihypertensive effect of guanfacine: long-term 'once-a-day' treatment and sudden withdrawal. ( Holló, J; Szám, I, 1981) |
" One group of animals received the norepinephrine α-2 agonist, guanfacine, or vehicle prior to anxiety testing 48 h after the last self-administration session." | 3.78 | Treatment of cocaine withdrawal anxiety with guanfacine: relationships to cocaine intake and reinstatement of cocaine seeking in rats. ( Baldwin, CK; Buffalari, DM; See, RE, 2012) |
"Twenty patients with essential hypertension were treated with guanfacine given in single 1-5 mg daily doses over a period of 24 weeks." | 3.66 | Long-term antihypertensive therapy with guanfacine. ( Holló, J; Szám, I, 1982) |
"Cocaine dependence is associated with increased stress and drug cue-induced craving and physiological arousal but decreased prefrontal activity to emotional and cognitive challenge." | 2.77 | Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings. ( Fox, HC; Hansen, J; Kimmerling, A; Morgan, PT; Seo, D; Sinha, R; Tuit, K, 2012) |
"Guanfacine was well tolerated with little evidence of fatigue and only small decreases in blood pressure: no dose was held due to hypotension." | 1.51 | Guanfacine decreases symptoms of cannabis withdrawal in daily cannabis smokers. ( Bedi, G; Comer, SD; Cooper, ZD; Foltin, RW; Haney, M; Herrmann, E; Levin, FR; Reed, SC, 2019) |
"Clonidine was about 12 times more potent than guanfacine in inhibiting this autonomic symptom of withdrawal." | 1.27 | A comparison of the inhibitory effects of clonidine and guanfacine on the behavioral and autonomic components of morphine withdrawal in rats. ( Buccafusco, JJ; Marshall, DC; Turner, RM, 1984) |
" The principal pharmacokinetic parameters of guanfacine were greatly altered, with extended biotransformation and a decrease in the half-life compared to the values observed in other cases of severe renal insufficiency." | 1.27 | Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure. ( Comoy, E; Fillastre, JP; Godin, M; Guerret, M; Kiechel, JR; Lavene, D, 1983) |
"Pretreatment with yohimbine (1." | 1.27 | Reversal by alpha-2 agonists of diazepam withdrawal hyperactivity in rats. ( Kulkarni, SK; Kunchandy, J, 1986) |
" We administered both drugs to rats using a dosage schedule which we had shown to produce hypertension and tachycardia when clonidine, but not guanfacine, was stopped after 3 weeks treatment." | 1.26 | Studies on clonidine and guanfacine withdrawal after short term treatment in the rat. ( Barber, ND; Reid, JL, 1982) |
"5." | 1.26 | Guanfacine: effects of long-term treatment and withdrawal. ( Hamilton, CA; Reid, JL; Zamboulis, C, 1980) |
Research
Studies (35)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 23 (65.71) | 18.7374 |
1990's | 7 (20.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 5 (14.29) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Holst, M | 1 |
Mathai, DS | 1 |
Patel, MM | 1 |
Rodgman, C | 1 |
Keller, J | 1 |
Hussain, MZ | 1 |
De La Garza, R | 1 |
Kosten, TR | 1 |
Verrico, CD | 1 |
Haney, M | 1 |
Cooper, ZD | 1 |
Bedi, G | 1 |
Herrmann, E | 1 |
Comer, SD | 1 |
Reed, SC | 1 |
Foltin, RW | 1 |
Levin, FR | 1 |
Bomfim, GH | 1 |
Verde, LF | 1 |
Frussa-Filho, R | 1 |
Jurkiewicz, A | 1 |
Jurkiewicz, NH | 1 |
Fox, HC | 1 |
Seo, D | 1 |
Tuit, K | 1 |
Hansen, J | 1 |
Kimmerling, A | 1 |
Morgan, PT | 1 |
Sinha, R | 1 |
Buffalari, DM | 1 |
Baldwin, CK | 1 |
See, RE | 1 |
van der Merwe, CJ | 1 |
Kruger, SA | 1 |
Zigun, JR | 1 |
Bannon, MJ | 1 |
Roth, RH | 1 |
Aleixandre, MA | 1 |
Colado, MI | 1 |
García de Jalón, PD | 1 |
Martín, MI | 1 |
Buccafusco, JJ | 1 |
Marshall, DC | 1 |
Turner, RM | 1 |
Schubert, H | 1 |
Fleischhacker, WW | 1 |
Meise, U | 1 |
Theohar, C | 2 |
Saameli, K | 1 |
Jerie, P | 2 |
Scholtysik, G | 1 |
Kiechel, JR | 1 |
Lavene, D | 1 |
Guerret, M | 1 |
Comoy, E | 1 |
Godin, M | 1 |
Fillastre, JP | 1 |
Szám, I | 2 |
Holló, J | 2 |
Barber, ND | 1 |
Reid, JL | 3 |
Manhem, P | 1 |
Hökfelt, B | 1 |
Zamboulis, C | 2 |
Hamilton, CA | 1 |
Bune, AJ | 1 |
Chalmers, JP | 1 |
Graham, JR | 1 |
Howe, PR | 1 |
West, MJ | 1 |
Wing, LM | 1 |
Thoolen, MJ | 1 |
Timmermans, PB | 1 |
van Zwieten, PA | 1 |
Legarda, JJ | 1 |
Gossop, M | 1 |
Rubio, G | 2 |
Alguacil, LF | 1 |
Alamo, C | 2 |
López-Muñoz, F | 2 |
Pascual, J | 1 |
López-Trabada, JR | 1 |
Arias, A | 1 |
Camí, J | 2 |
Gilabert, M | 1 |
San, L | 2 |
de la Torre, R | 1 |
Navarro, M | 1 |
Lizasoain, I | 1 |
Leza, JC | 1 |
Lorenzo, P | 1 |
Peri, JM | 1 |
Mata, R | 1 |
Porta, M | 1 |
Muga, R | 1 |
Tor, J | 1 |
Forteza-Rei, J | 1 |
Jacas, C | 1 |
Altés, J | 1 |
Mestre, L | 1 |
Gorceix, A | 1 |
Dugarin, J | 1 |
Pommier, F | 1 |
Minami, M | 1 |
Togashi, H | 1 |
Yoshioka, M | 1 |
Parale, MP | 1 |
Kulkarni, SK | 2 |
Kunchandy, J | 1 |
Soler Insa, PA | 1 |
Bedate Villar, J | 1 |
Yotis, A | 1 |
Wilson, MF | 1 |
Haring, O | 1 |
Lewin, A | 1 |
Bedsole, G | 1 |
Stepansky, W | 1 |
Fillingim, J | 1 |
Hall, D | 1 |
Roginsky, M | 1 |
McMahon, FG | 1 |
Jagger, P | 1 |
Sorkin, EM | 1 |
Heel, RC | 1 |
Reviews
1 review available for guanfacine and Drug Withdrawal Symptoms
Article | Year |
---|---|
Guanfacine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension.
Topics: Blood Pressure; Disease; Drug Interactions; Endocrine Glands; Guanfacine; Guanidines; Hemodynamics; | 1986 |
Trials
10 trials available for guanfacine and Drug Withdrawal Symptoms
Article | Year |
---|---|
Use of Guanfacine for Cannabis Use Disorder and Related Symptomology.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Affect; Craving; Dronabinol; Female; Guanfacine; Humans | 2019 |
Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Cocaine-Related Disorders; Combined Modality Therapy; C | 2012 |
The antihypertensive effect of guanfacine compared with methyldopa.
Topics: Adrenergic alpha-Agonists; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; | 1980 |
Preliminary results of guanfacine treatment of acute opiate withdrawal.
Topics: Acute Disease; Adrenergic alpha-Agonists; Adult; Clinical Trials as Topic; Female; Guanfacine; Guani | 1984 |
Double-blind trial comparing guanfacine and methyldopa in patients with essential hypertension.
Topics: Antihypertensive Agents; Clinical Trials as Topic; Double-Blind Method; Guanfacine; Guanidines; Huma | 1981 |
Antihypertensive effect of guanfacine: long-term 'once-a-day' treatment and sudden withdrawal.
Topics: Adult; Aged; Antihypertensive Agents; Drug Administration Schedule; Female; Guanfacine; Guanidines; | 1981 |
Hypercortisolism after opioid discontinuation in rapid detoxification of heroin addicts.
Topics: Adult; Circadian Rhythm; Clonidine; Double-Blind Method; Guanfacine; Heroin; Heroin Dependence; Huma | 1992 |
Efficacy of clonidine, guanfacine and methadone in the rapid detoxification of heroin addicts: a controlled clinical trial.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Female; Guanfacine; Guanidines; Heroin Dependence; Huma | 1990 |
[Comparative effectiveness of alpha-2 adrenergic agonists (clonidine-guanfacine) in the hospital detoxification of opiate addicts].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Blood Pressure; Clonidine; Double-Blind Method; Drug E | 1990 |
Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertension.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Evaluation; Fe | 1986 |
Other Studies
24 other studies available for guanfacine and Drug Withdrawal Symptoms
Article | Year |
---|---|
Guanfacine decreases symptoms of cannabis withdrawal in daily cannabis smokers.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Affect; Anorexia; Blood Pressure; Cannabis; Feeding Beh | 2019 |
Functional effects of alcohol withdrawal syndrome on peripheral sympathetic neurotransmission in vas deferens of adult rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Calcium Channels; Catecholamines; Chromatography, Hig | 2014 |
Treatment of cocaine withdrawal anxiety with guanfacine: relationships to cocaine intake and reinstatement of cocaine seeking in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Cocaine; Drug-Seeking Behavior; Extinction, Psychological; Gu | 2012 |
Comparison of two alpha-noradrenergic agonists (clonidine and guanfacine) on norepinephrine turnover in the cortex of rats during morphine abstinence.
Topics: Adrenergic alpha-Agonists; Animals; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Gu | 1981 |
Influences on morphine action in the myenteric plexus from guinea pig of alpha 2 receptor stimulation.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Drug Synergism; Female; Guanfacine; Guanidines; Guine | 1983 |
A comparison of the inhibitory effects of clonidine and guanfacine on the behavioral and autonomic components of morphine withdrawal in rats.
Topics: Adrenergic alpha-Agonists; Animals; Autonomic Nervous System; Behavior, Animal; Blood Pressure; Clon | 1984 |
Guanfacine and other centrally acting drugs in antihypertensive therapy; pharmacological and clinical aspects.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; Cats; Dogs; Guanfacine; Guanidines; Humans; | 1982 |
Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure.
Topics: Female; Guanfacine; Guanidines; Humans; Hypertension; Kidney Failure, Chronic; Kinetics; Middle Aged | 1983 |
Long-term antihypertensive therapy with guanfacine.
Topics: Adult; Aged; Blood Pressure; Electrocardiography; Female; Guanfacine; Guanidines; Heart Rate; Humans | 1982 |
Studies on clonidine and guanfacine withdrawal after short term treatment in the rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Guanfacine; Guanidines; Heart Rate; Hum | 1982 |
Blood pressure, heart rate, catecholamines and plasma renin activity following institution and withdrawal of guanfacine treatment in moderate hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Catecholamines; Female; Guanfacine; Guanidines; Hear | 1980 |
Clinical experience with guanfacine in long-term treatment of hypertension. Part II: adverse reactions to guanfacine.
Topics: Antihypertensive Agents; Body Weight; Clonidine; Dose-Response Relationship, Drug; Drug Administrati | 1980 |
Guanfacine: effects of long-term treatment and withdrawal.
Topics: Antihypertensive Agents; Blood Pressure; Female; Guanfacine; Guanidines; Heart Rate; Humans; Hyperte | 1980 |
Withdrawal of guanfacine after long-term treatment in essential hypertension. Observations on blood pressure and plasma and urinary noradrenaline.
Topics: Blood Pressure; Female; Guanfacine; Guanidines; Humans; Hypertension; Male; Middle Aged; Norepinephr | 1981 |
Guanfacine and clonidine: antihypertensive and withdrawal characteristics after continuous infusion and its interruption in the spontaneously hypertensive and normotensive rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Catheters, Indwelling; Clonidine; Guanfacine; Guan | 1982 |
A 24-h inpatient detoxification treatment for heroin addicts: a preliminary investigation.
Topics: Administration, Oral; Adult; Conscious Sedation; Drug Administration Schedule; Follow-Up Studies; Gu | 1994 |
Cardiovascular parameters of heroin-withdrawn addicts treated with guanfacine.
Topics: Adrenergic alpha-Agonists; Blood Pressure; Guanfacine; Heart Rate; Heroin; Heroin Dependence; Humans | 1997 |
[Cardiovascular changes during alpha-2 agonist treatment of opiate withdrawal syndrome].
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Guanfacine; Heart Rate; Heroin; Heroi | 1998 |
An original method for assessment of the jumping test.
Topics: Animals; Behavior, Animal; Caffeine; Guanfacine; Male; Methods; Mice; Mice, Inbred Strains; Morphine | 1991 |
[Use of presynaptic alpha-mimetics for withdrawal in heroin addicts].
Topics: Adrenergic alpha-Agonists; Adult; Female; Guanabenz; Guanfacine; Guanidines; Heroin Dependence; Hosp | 1985 |
[The effect of clonidine and guanfacine on blood pressure].
Topics: Animals; Autonomic Fibers, Preganglionic; Behavior, Animal; Blood Pressure; Brain; Cardiovascular Sy | 1985 |
Studies with alpha 2-adrenoceptor agonists and alcohol abstinence syndrome in rats.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Clonidine; Ethanol; Guanfacine; Guanidines; Male; Phen | 1986 |
Reversal by alpha-2 agonists of diazepam withdrawal hyperactivity in rats.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Clonidine; Diazepam; Guanfacine; Guanidines; Male; Mot | 1986 |
Treatment of heroin withdrawal with guanfacine: an open clinical investigation.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Dose-Response Relationship, Drug; Female; Guanfacine; | 1987 |