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guanfacine and Drug Withdrawal Symptoms

guanfacine has been researched along with Drug Withdrawal Symptoms in 35 studies

Guanfacine: A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.

Research Excerpts

ExcerptRelevanceReference
"Guanfacine, an alpha 2-adrenoceptor agonist, was compared with clonidine as step-2 therapy of mild to moderate essential hypertension in a 24-week, double-blind, randomized, parallel evaluation to determine efficacy, safety and occurrence of withdrawal syndrome."9.06Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertension. ( Bedsole, G; Fillingim, J; Hall, D; Haring, O; Jagger, P; Lewin, A; McMahon, FG; Roginsky, M; Stepansky, W; Wilson, MF, 1986)
" One group of animals received the norepinephrine α-2 agonist, guanfacine, or vehicle prior to anxiety testing 48 h after the last self-administration session."7.78Treatment of cocaine withdrawal anxiety with guanfacine: relationships to cocaine intake and reinstatement of cocaine seeking in rats. ( Baldwin, CK; Buffalari, DM; See, RE, 2012)
"Guanfacine, an alpha 2-adrenoceptor agonist, was compared with clonidine as step-2 therapy of mild to moderate essential hypertension in a 24-week, double-blind, randomized, parallel evaluation to determine efficacy, safety and occurrence of withdrawal syndrome."5.06Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertension. ( Bedsole, G; Fillingim, J; Hall, D; Haring, O; Jagger, P; Lewin, A; McMahon, FG; Roginsky, M; Stepansky, W; Wilson, MF, 1986)
" A comparison of its anti-hypertensive effect with that of methyldopa was made in patients with essential hypertension."5.05The antihypertensive effect of guanfacine compared with methyldopa. ( Kruger, SA; van der Merwe, CJ, 1980)
" Twenty patients with essential hypertension were treated with guanfacine given in single daily doses of 1--5 mg over a period of 24 weeks."5.05Antihypertensive effect of guanfacine: long-term 'once-a-day' treatment and sudden withdrawal. ( Holló, J; Szám, I, 1981)
" One group of animals received the norepinephrine α-2 agonist, guanfacine, or vehicle prior to anxiety testing 48 h after the last self-administration session."3.78Treatment of cocaine withdrawal anxiety with guanfacine: relationships to cocaine intake and reinstatement of cocaine seeking in rats. ( Baldwin, CK; Buffalari, DM; See, RE, 2012)
"Twenty patients with essential hypertension were treated with guanfacine given in single 1-5 mg daily doses over a period of 24 weeks."3.66Long-term antihypertensive therapy with guanfacine. ( Holló, J; Szám, I, 1982)
"Cocaine dependence is associated with increased stress and drug cue-induced craving and physiological arousal but decreased prefrontal activity to emotional and cognitive challenge."2.77Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings. ( Fox, HC; Hansen, J; Kimmerling, A; Morgan, PT; Seo, D; Sinha, R; Tuit, K, 2012)
"Guanfacine was well tolerated with little evidence of fatigue and only small decreases in blood pressure: no dose was held due to hypotension."1.51Guanfacine decreases symptoms of cannabis withdrawal in daily cannabis smokers. ( Bedi, G; Comer, SD; Cooper, ZD; Foltin, RW; Haney, M; Herrmann, E; Levin, FR; Reed, SC, 2019)
"Clonidine was about 12 times more potent than guanfacine in inhibiting this autonomic symptom of withdrawal."1.27A comparison of the inhibitory effects of clonidine and guanfacine on the behavioral and autonomic components of morphine withdrawal in rats. ( Buccafusco, JJ; Marshall, DC; Turner, RM, 1984)
" The principal pharmacokinetic parameters of guanfacine were greatly altered, with extended biotransformation and a decrease in the half-life compared to the values observed in other cases of severe renal insufficiency."1.27Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure. ( Comoy, E; Fillastre, JP; Godin, M; Guerret, M; Kiechel, JR; Lavene, D, 1983)
"Pretreatment with yohimbine (1."1.27Reversal by alpha-2 agonists of diazepam withdrawal hyperactivity in rats. ( Kulkarni, SK; Kunchandy, J, 1986)
" We administered both drugs to rats using a dosage schedule which we had shown to produce hypertension and tachycardia when clonidine, but not guanfacine, was stopped after 3 weeks treatment."1.26Studies on clonidine and guanfacine withdrawal after short term treatment in the rat. ( Barber, ND; Reid, JL, 1982)
"5."1.26Guanfacine: effects of long-term treatment and withdrawal. ( Hamilton, CA; Reid, JL; Zamboulis, C, 1980)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199023 (65.71)18.7374
1990's7 (20.00)18.2507
2000's0 (0.00)29.6817
2010's5 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Holst, M1
Mathai, DS1
Patel, MM1
Rodgman, C1
Keller, J1
Hussain, MZ1
De La Garza, R1
Kosten, TR1
Verrico, CD1
Haney, M1
Cooper, ZD1
Bedi, G1
Herrmann, E1
Comer, SD1
Reed, SC1
Foltin, RW1
Levin, FR1
Bomfim, GH1
Verde, LF1
Frussa-Filho, R1
Jurkiewicz, A1
Jurkiewicz, NH1
Fox, HC1
Seo, D1
Tuit, K1
Hansen, J1
Kimmerling, A1
Morgan, PT1
Sinha, R1
Buffalari, DM1
Baldwin, CK1
See, RE1
van der Merwe, CJ1
Kruger, SA1
Zigun, JR1
Bannon, MJ1
Roth, RH1
Aleixandre, MA1
Colado, MI1
García de Jalón, PD1
Martín, MI1
Buccafusco, JJ1
Marshall, DC1
Turner, RM1
Schubert, H1
Fleischhacker, WW1
Meise, U1
Theohar, C2
Saameli, K1
Jerie, P2
Scholtysik, G1
Kiechel, JR1
Lavene, D1
Guerret, M1
Comoy, E1
Godin, M1
Fillastre, JP1
Szám, I2
Holló, J2
Barber, ND1
Reid, JL3
Manhem, P1
Hökfelt, B1
Zamboulis, C2
Hamilton, CA1
Bune, AJ1
Chalmers, JP1
Graham, JR1
Howe, PR1
West, MJ1
Wing, LM1
Thoolen, MJ1
Timmermans, PB1
van Zwieten, PA1
Legarda, JJ1
Gossop, M1
Rubio, G2
Alguacil, LF1
Alamo, C2
López-Muñoz, F2
Pascual, J1
López-Trabada, JR1
Arias, A1
Camí, J2
Gilabert, M1
San, L2
de la Torre, R1
Navarro, M1
Lizasoain, I1
Leza, JC1
Lorenzo, P1
Peri, JM1
Mata, R1
Porta, M1
Muga, R1
Tor, J1
Forteza-Rei, J1
Jacas, C1
Altés, J1
Mestre, L1
Gorceix, A1
Dugarin, J1
Pommier, F1
Minami, M1
Togashi, H1
Yoshioka, M1
Parale, MP1
Kulkarni, SK2
Kunchandy, J1
Soler Insa, PA1
Bedate Villar, J1
Yotis, A1
Wilson, MF1
Haring, O1
Lewin, A1
Bedsole, G1
Stepansky, W1
Fillingim, J1
Hall, D1
Roginsky, M1
McMahon, FG1
Jagger, P1
Sorkin, EM1
Heel, RC1

Reviews

1 review available for guanfacine and Drug Withdrawal Symptoms

ArticleYear
Guanfacine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension.
    Drugs, 1986, Volume: 31, Issue:4

    Topics: Blood Pressure; Disease; Drug Interactions; Endocrine Glands; Guanfacine; Guanidines; Hemodynamics;

1986

Trials

10 trials available for guanfacine and Drug Withdrawal Symptoms

ArticleYear
Use of Guanfacine for Cannabis Use Disorder and Related Symptomology.
    The American journal on addictions, 2019, Volume: 28, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Affect; Craving; Dronabinol; Female; Guanfacine; Humans

2019
Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:7

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Cocaine-Related Disorders; Combined Modality Therapy; C

2012
The antihypertensive effect of guanfacine compared with methyldopa.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1980, Mar-15, Volume: 57, Issue:11

    Topics: Adrenergic alpha-Agonists; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method;

1980
Preliminary results of guanfacine treatment of acute opiate withdrawal.
    The American journal of psychiatry, 1984, Volume: 141, Issue:10

    Topics: Acute Disease; Adrenergic alpha-Agonists; Adult; Clinical Trials as Topic; Female; Guanfacine; Guani

1984
Double-blind trial comparing guanfacine and methyldopa in patients with essential hypertension.
    European journal of clinical pharmacology, 1981, Volume: 19, Issue:5

    Topics: Antihypertensive Agents; Clinical Trials as Topic; Double-Blind Method; Guanfacine; Guanidines; Huma

1981
Antihypertensive effect of guanfacine: long-term 'once-a-day' treatment and sudden withdrawal.
    Clinical science (London, England : 1979), 1981, Volume: 61 Suppl 7

    Topics: Adult; Aged; Antihypertensive Agents; Drug Administration Schedule; Female; Guanfacine; Guanidines;

1981
Hypercortisolism after opioid discontinuation in rapid detoxification of heroin addicts.
    British journal of addiction, 1992, Volume: 87, Issue:8

    Topics: Adult; Circadian Rhythm; Clonidine; Double-Blind Method; Guanfacine; Heroin; Heroin Dependence; Huma

1992
Efficacy of clonidine, guanfacine and methadone in the rapid detoxification of heroin addicts: a controlled clinical trial.
    British journal of addiction, 1990, Volume: 85, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Female; Guanfacine; Guanidines; Heroin Dependence; Huma

1990
[Comparative effectiveness of alpha-2 adrenergic agonists (clonidine-guanfacine) in the hospital detoxification of opiate addicts].
    Medicina clinica, 1990, Feb-10, Volume: 94, Issue:5

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Blood Pressure; Clonidine; Double-Blind Method; Drug E

1990
Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertension.
    The American journal of cardiology, 1986, Mar-28, Volume: 57, Issue:9

    Topics: Adult; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Evaluation; Fe

1986

Other Studies

24 other studies available for guanfacine and Drug Withdrawal Symptoms

ArticleYear
Guanfacine decreases symptoms of cannabis withdrawal in daily cannabis smokers.
    Addiction biology, 2019, Volume: 24, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Affect; Anorexia; Blood Pressure; Cannabis; Feeding Beh

2019
Functional effects of alcohol withdrawal syndrome on peripheral sympathetic neurotransmission in vas deferens of adult rats.
    Life sciences, 2014, Jul-11, Volume: 108, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Calcium Channels; Catecholamines; Chromatography, Hig

2014
Treatment of cocaine withdrawal anxiety with guanfacine: relationships to cocaine intake and reinstatement of cocaine seeking in rats.
    Psychopharmacology, 2012, Volume: 223, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Cocaine; Drug-Seeking Behavior; Extinction, Psychological; Gu

2012
Comparison of two alpha-noradrenergic agonists (clonidine and guanfacine) on norepinephrine turnover in the cortex of rats during morphine abstinence.
    European journal of pharmacology, 1981, Apr-09, Volume: 70, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Gu

1981
Influences on morphine action in the myenteric plexus from guinea pig of alpha 2 receptor stimulation.
    Archivos de farmacologia y toxicologia, 1983, Volume: 9, Issue:3

    Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Drug Synergism; Female; Guanfacine; Guanidines; Guine

1983
A comparison of the inhibitory effects of clonidine and guanfacine on the behavioral and autonomic components of morphine withdrawal in rats.
    Life sciences, 1984, Sep-24, Volume: 35, Issue:13

    Topics: Adrenergic alpha-Agonists; Animals; Autonomic Nervous System; Behavior, Animal; Blood Pressure; Clon

1984
Guanfacine and other centrally acting drugs in antihypertensive therapy; pharmacological and clinical aspects.
    Clinical and experimental hypertension. Part A, Theory and practice, 1982, Volume: 4, Issue:1-2

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; Cats; Dogs; Guanfacine; Guanidines; Humans;

1982
Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure.
    European journal of clinical pharmacology, 1983, Volume: 25, Issue:4

    Topics: Female; Guanfacine; Guanidines; Humans; Hypertension; Kidney Failure, Chronic; Kinetics; Middle Aged

1983
Long-term antihypertensive therapy with guanfacine.
    International journal of clinical pharmacology, therapy, and toxicology, 1982, Volume: 20, Issue:8

    Topics: Adult; Aged; Blood Pressure; Electrocardiography; Female; Guanfacine; Guanidines; Heart Rate; Humans

1982
Studies on clonidine and guanfacine withdrawal after short term treatment in the rat.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 259, Issue:1

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Guanfacine; Guanidines; Heart Rate; Hum

1982
Blood pressure, heart rate, catecholamines and plasma renin activity following institution and withdrawal of guanfacine treatment in moderate hypertension.
    British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Catecholamines; Female; Guanfacine; Guanidines; Hear

1980
Clinical experience with guanfacine in long-term treatment of hypertension. Part II: adverse reactions to guanfacine.
    British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1

    Topics: Antihypertensive Agents; Body Weight; Clonidine; Dose-Response Relationship, Drug; Drug Administrati

1980
Guanfacine: effects of long-term treatment and withdrawal.
    British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1

    Topics: Antihypertensive Agents; Blood Pressure; Female; Guanfacine; Guanidines; Heart Rate; Humans; Hyperte

1980
Withdrawal of guanfacine after long-term treatment in essential hypertension. Observations on blood pressure and plasma and urinary noradrenaline.
    European journal of clinical pharmacology, 1981, Volume: 19, Issue:1

    Topics: Blood Pressure; Female; Guanfacine; Guanidines; Humans; Hypertension; Male; Middle Aged; Norepinephr

1981
Guanfacine and clonidine: antihypertensive and withdrawal characteristics after continuous infusion and its interruption in the spontaneously hypertensive and normotensive rat.
    Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 319, Issue:1

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Catheters, Indwelling; Clonidine; Guanfacine; Guan

1982
A 24-h inpatient detoxification treatment for heroin addicts: a preliminary investigation.
    Drug and alcohol dependence, 1994, Volume: 35, Issue:2

    Topics: Administration, Oral; Adult; Conscious Sedation; Drug Administration Schedule; Follow-Up Studies; Gu

1994
Cardiovascular parameters of heroin-withdrawn addicts treated with guanfacine.
    Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:3

    Topics: Adrenergic alpha-Agonists; Blood Pressure; Guanfacine; Heart Rate; Heroin; Heroin Dependence; Humans

1997
[Cardiovascular changes during alpha-2 agonist treatment of opiate withdrawal syndrome].
    Revista clinica espanola, 1998, Volume: 198, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Guanfacine; Heart Rate; Heroin; Heroi

1998
An original method for assessment of the jumping test.
    Methods and findings in experimental and clinical pharmacology, 1991, Volume: 13, Issue:7

    Topics: Animals; Behavior, Animal; Caffeine; Guanfacine; Male; Methods; Mice; Mice, Inbred Strains; Morphine

1991
[Use of presynaptic alpha-mimetics for withdrawal in heroin addicts].
    Annales de medecine interne, 1985, Volume: 136, Issue:5

    Topics: Adrenergic alpha-Agonists; Adult; Female; Guanabenz; Guanfacine; Guanidines; Heroin Dependence; Hosp

1985
[The effect of clonidine and guanfacine on blood pressure].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1985, Volume: 86, Issue:4

    Topics: Animals; Autonomic Fibers, Preganglionic; Behavior, Animal; Blood Pressure; Brain; Cardiovascular Sy

1985
Studies with alpha 2-adrenoceptor agonists and alcohol abstinence syndrome in rats.
    Psychopharmacology, 1986, Volume: 88, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Azepines; Clonidine; Ethanol; Guanfacine; Guanidines; Male; Phen

1986
Reversal by alpha-2 agonists of diazepam withdrawal hyperactivity in rats.
    Psychopharmacology, 1986, Volume: 90, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Azepines; Clonidine; Diazepam; Guanfacine; Guanidines; Male; Mot

1986
Treatment of heroin withdrawal with guanfacine: an open clinical investigation.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1987, Volume: 32, Issue:8

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Dose-Response Relationship, Drug; Female; Guanfacine;

1987
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