guanfacine has been researched along with Blood Pressure, High in 155 studies
Guanfacine: A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Guanfacine, an alpha-2 adrenoceptor agonist, was compared with methyldopa as step-2 therapy for patients with mild-to-moderate essential hypertension in a 12-week, double-blind, randomized, parallel evaluation of efficacy and safety." | 9.07 | Antihypertensive efficacy of guanfacine and methyldopa in patients with mild to moderate essential hypertension. ( Blackshear, J; Lovallo, WR; Mathur, P; Parsons, OA; Wilson, MF, 1991) |
| "Guanfacine, an alpha 2 adrenoceptor agonist, was compared with prazosin hydrochloride for the treatment of patients with mild to moderate essential hypertension in an 8-week, double-blind, randomized, parallel evaluation to determine efficacy and safety." | 9.06 | Antihypertensive efficacy of guanfacine and prazosin in patients with mild to moderate essential hypertension. ( Alderman, MH; Lewin, A; Mathur, P, 1990) |
| "Guanfacine, an alpha-adrenoceptor agonist, may exhibit distinct dose-related curves for efficacy and adverse effects in the step-2 therapy of essential hypertension." | 9.06 | A multicenter, randomized, double-blind dose-response evaluation of step-2 guanfacine versus placebo in mild to moderate hypertension. ( Alderman, MH; Canosa, FL; Finnerty, FA; Kessler, WB; Marlon, AM; Materson, BJ; McMillen, JI; Savran, SV, 1986) |
| "Guanfacine, an alpha 2-adrenoceptor agonist, was compared with clonidine as step-2 therapy of mild to moderate essential hypertension in a 24-week, double-blind, randomized, parallel evaluation to determine efficacy, safety and occurrence of withdrawal syndrome." | 9.06 | Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertension. ( Bedsole, G; Fillingim, J; Hall, D; Haring, O; Jagger, P; Lewin, A; McMahon, FG; Roginsky, M; Stepansky, W; Wilson, MF, 1986) |
| "The paper offers therapeutic experience with guanfacine (Estulic Sandoz) in large and small doses in patients with hypertension." | 9.06 | Small and large doses of guanfacine (Estulic Sandoz) in the treatment of hypertension. ( Mayer, O; Polívková, H, 1987) |
| "3 mg clonidine and 3 mg guanfacine were equiactive in decreasing blood pressure and heart rate in 17 subjects with essential hypertension." | 9.05 | Effects of clonidine and guanfacine in essential hypertension. ( Alföldi, S; Farsang, C; Kapocsi, J; Vajda, L; Varga, K, 1984) |
| "The antihypertensive and side effects of guanfacine and clonidine were compared in 24 patients with essential hypertension in a single-blind crossover study." | 9.05 | Evaluation of guanfacine and clonidine in essential hypertension: a single-blind crossover study. ( Louis, WJ; Miach, PJ, 1980) |
| "Control of hypertension (ie, reduction of blood pressure to less than or equal to 160/90 mmHg) in 40 mild to moderate hypertensives not responding adequately to hydrochlorothiazide was achieved by the addition of guanfacine (once daily) or methyldopa (twice daily) in a 16-week, double-blind, parallel-group trial." | 9.05 | Comparison of once-daily guanfacine and twice-a-day methyldopa in the treatment of mild to moderate hypertension. ( Bouchard, S; Brookman, S; Farooki, MS; Farsky, K; Lalonde, Y, 1985) |
| " Twenty-two patients with moderately severe essential hypertension were treated for a period of 12 months with guanfacine (BS 100-141), a new centrally-acting antihypertensive agent." | 9.05 | Evaluation of long-term treatment of essential hypertension with guanfacine. ( Higuchi, M; Overlack, A; Stumpe, KO, 1980) |
| "This study of guanfacine in 27 patients suffering from moderate-to-severe hypertension showed a satisfactory blood pressure control in 26 patients." | 9.05 | Guanfacine alone and in combination therapy in the treatment of moderate and severe hypertension. ( Seedat, YK, 1983) |
| " Thirty pregnant women aged 22-34 yr presenting with pre-eclampsia were treated with guanfacine for periods of 16-68 days." | 9.05 | Guanfacine in the treatment of hypertension due to pre-eclamptic toxaemia in thirty women. ( Philipp, E, 1980) |
| "The hypotensive action of guanfacine and alpha-methyldopa has been compared in 30 patients wth moderate essential hypertension." | 9.05 | Long term comparative study of guanfacine and alpha-methyldopa in essential hypertension. ( Condorelli, M; Rengo, F; Ricciardelli, B; Saccà, L; Trimarco, B; Volpe, M, 1980) |
| "A 16-year-old female with Tourette's syndrome presented with diaphoresis, dry mouth, and hypertension 8 h after ingesting 25 mg of guanfacine." | 7.76 | Guanfacine overdose resulting in initial hypertension and subsequent delayed, persistent orthostatic hypotension. ( Clark, RF; Minns, AB; Schneir, A, 2010) |
| "30 patients with hypertension and diabetes mellitus type II were treated with guanfacine (Estulic--"Sandoz" Switzerland) 1 mg tablets in the course of 6 months." | 7.68 | [Guanfacine in the treatment of arterial hypertension in diabetics]. ( Belovezhdov, N; Daskalova, I; Monova, D, 1990) |
| "Hemodynamic evaluation of three men and eight women aged 20 to 58 years (mean, 44 years) with essential hypertension was performed before and after a single dose of guanfacine and before and after long-term administration of the drug, which is a stimulant of central alpha-adrenergic receptors." | 7.67 | Hemodynamic effects of guanfacine in essential hypertension. ( Burucúa, JE; Cohen, AA; Feldstein, CA; Sabaris, RP, 1984) |
| "The evolution of blood pressure, heart rate, epinephrine, norepinephrine, angiotensin II and plasma renin activity has been studied in 10 patients with essential arterial hypertension before and during a two months period of treatment with guanfacine, a new centrally acting hypotensive drug." | 7.67 | Relationships between blood pressure, heart rate and plasma epinephrine, norepinephrine, angiotensin II concentrations, plasma renin activity during chronic guanfacine therapy in patients with essential arterial hypertension. ( Collart, F; Staroukine, M; Verniory, A, 1985) |
| "More than 5,000 primary-care physicians enrolled more than 22,000 patients with mild to moderate hypertension in a postmarketing study in which guanfacine hydrochloride, a centrally acting antihypertensive agent, was given for 28 days." | 7.67 | A postmarketing evaluation of guanfacine hydrochloride in mild to moderate hypertension. ( Board, AW; Carchman, SH; Nyman, CE; Perry, VP; Shepperson, BE, 1988) |
| "During three-month therapy with small doses of guanfacine (Estulic Sandoz) that were sufficient to control blood pressure in patients with stage II essential hypertension and led to a decrease in excretion of noradrenaline and vanillylmandelic acid, the authors found a decrease in the level of blood cholesterol in patients with hyperlipidaemia." | 7.67 | The effect of small doses of guanfacine (Estulic Sandoz) on the lipid levels and catecholamine excretion in patients with essential hypertension. ( Balazovjech, I; Kratochvíl'ová, H; Mikulecký, M; Skultétyová, D, 1987) |
| "The effect of single-dose, short-term (6 weeks) and long-term (7 years) guanfacine therapy on various endocrine and metabolic parameters was evaluated in patients with moderate essential hypertension (WHO phase I and II)." | 7.67 | Effects of guanfacine on growth hormone, prolactin, renin, lipoproteins and glucose in essential hypertension. ( Balossi, EC; Hauger-Klevene, JH; Scornavacchi, JC, 1986) |
| "The effects of oral guanfacine were examined in six patients with essential hypertension." | 7.66 | Effects of single and multiple doses of guanfacine in essential hypertension. ( Reid, JL; Zamboulis, C, 1980) |
| " The acute and chronic effects of guanfacine on blood pressure, plasma noradrenaline concentration and plasma renin activity were investigated in 23 patients (15 males, 8 females) with essential hypertension (WHO grade I-II)." | 7.66 | Guanfacine in essential hypertension: effect on blood pressure, plasma noradrenaline concentration and plasma renin activity. ( Brecht, HM; Schoeppe, W, 1980) |
| "Guanfacine monotherapy was again shown to be an effective initial treatment for mild essential hypertension with no adverse influence on serum lipids." | 6.66 | Guanfacine as monotherapy for systemic hypertension. ( Blackshear, JL; Fillingim, JM; Strauss, A; Strauss, M, 1986) |
| "The results of one year's treatment of 243 hypertensive patients with guanfacine, given alone in a variety of doses and dosage schedules, were analyzed in terms of antihypertensive efficacy and incidence of side effects." | 6.65 | Guanfacine in the treatment of hypertension: two years' experience with low dose monotherapy. ( Jerie, P; Lasance, A, 1981) |
| "Guanfacine monotherapy was effective in 75% of patients with moderate hypertension (using low doses 1-3 mg/day)." | 5.28 | [Hypotensive and hemodynamic effects of guanfacine in arterial hypertension]. ( Beliakova, EV; Charyev, KhZ; Erina, EV; Panfilov, VV, 1989) |
| " Guanfacine in once-daily dosage reduced BP during rest (supine BP: control, 175 +/- 6/103 +/- 4 mm Hg; 1 yr guanfacine, 161 +/- 5/91 +/- 3 mm Hg)." | 5.27 | Guanfacine in essential hypertension: effects during rest and isometric exercise. ( Hedner, T; Mellstrand, T; Nyberg, G, 1984) |
| "Guanfacine treatment is accompanied by relatively few and slight side-effects." | 5.26 | [Blood pressure and renin under treatment of hypertension with guanfacine (author's transl)]. ( Jäger, H; Rosenthal, J, 1980) |
| "Guanfacine, an alpha-2 adrenoceptor agonist, was compared with methyldopa as step-2 therapy for patients with mild-to-moderate essential hypertension in a 12-week, double-blind, randomized, parallel evaluation of efficacy and safety." | 5.07 | Antihypertensive efficacy of guanfacine and methyldopa in patients with mild to moderate essential hypertension. ( Blackshear, J; Lovallo, WR; Mathur, P; Parsons, OA; Wilson, MF, 1991) |
| "The paper offers therapeutic experience with guanfacine (Estulic Sandoz) in large and small doses in patients with hypertension." | 5.06 | Small and large doses of guanfacine (Estulic Sandoz) in the treatment of hypertension. ( Mayer, O; Polívková, H, 1987) |
| "Guanfacine, an alpha-adrenoceptor agonist, may exhibit distinct dose-related curves for efficacy and adverse effects in the step-2 therapy of essential hypertension." | 5.06 | A multicenter, randomized, double-blind dose-response evaluation of step-2 guanfacine versus placebo in mild to moderate hypertension. ( Alderman, MH; Canosa, FL; Finnerty, FA; Kessler, WB; Marlon, AM; Materson, BJ; McMillen, JI; Savran, SV, 1986) |
| "Efficacy of guanfacine was studied in 20 hypertensive patients and 20 patients with diabetes mellitus and hypertension in a 12-month follow-up." | 5.06 | Long-term clinical experience with guanfacine. ( Brimichová, G; Dzúrik, R; Fetkovská, N; Sebeková, K, 1987) |
| "Guanfacine, an alpha 2 adrenoceptor agonist, was compared with prazosin hydrochloride for the treatment of patients with mild to moderate essential hypertension in an 8-week, double-blind, randomized, parallel evaluation to determine efficacy and safety." | 5.06 | Antihypertensive efficacy of guanfacine and prazosin in patients with mild to moderate essential hypertension. ( Alderman, MH; Lewin, A; Mathur, P, 1990) |
| "Guanfacine, an alpha 2-adrenoceptor agonist, was compared with clonidine as step-2 therapy of mild to moderate essential hypertension in a 24-week, double-blind, randomized, parallel evaluation to determine efficacy, safety and occurrence of withdrawal syndrome." | 5.06 | Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertension. ( Bedsole, G; Fillingim, J; Hall, D; Haring, O; Jagger, P; Lewin, A; McMahon, FG; Roginsky, M; Stepansky, W; Wilson, MF, 1986) |
| " A comparison of its anti-hypertensive effect with that of methyldopa was made in patients with essential hypertension." | 5.05 | The antihypertensive effect of guanfacine compared with methyldopa. ( Kruger, SA; van der Merwe, CJ, 1980) |
| "This study of guanfacine in 27 patients suffering from moderate-to-severe hypertension showed a satisfactory blood pressure control in 26 patients." | 5.05 | Guanfacine alone and in combination therapy in the treatment of moderate and severe hypertension. ( Seedat, YK, 1983) |
| "3 mg clonidine and 3 mg guanfacine were equiactive in decreasing blood pressure and heart rate in 17 subjects with essential hypertension." | 5.05 | Effects of clonidine and guanfacine in essential hypertension. ( Alföldi, S; Farsang, C; Kapocsi, J; Vajda, L; Varga, K, 1984) |
| "The hypotensive action of guanfacine and alpha-methyldopa has been compared in 30 patients wth moderate essential hypertension." | 5.05 | Long term comparative study of guanfacine and alpha-methyldopa in essential hypertension. ( Condorelli, M; Rengo, F; Ricciardelli, B; Saccà, L; Trimarco, B; Volpe, M, 1980) |
| " Sixteen patients with essential hypertension were treated with guanfacine and with clonidine for 5 weeks each in a double-blind, placebo-controlled, cross-over trial." | 5.05 | Antihypertensive effect of guanfacine: a double-blind cross-over trial compared with clonidine. ( Distler, A; Kirch, W; Lüth, B, 1980) |
| "In a multicenter study with 54 patients with essential and renal hypertension (WHO I to III) the antihypertensive efficacy and safety of guanfacine were evaluated against clonidine in a double blind cross-over design." | 5.05 | [A new antihypertensive agent used in a clinical setting]. ( Kaiser, HJ; Raschig, A; Wetzels, E, 1980) |
| " Thirty pregnant women aged 22-34 yr presenting with pre-eclampsia were treated with guanfacine for periods of 16-68 days." | 5.05 | Guanfacine in the treatment of hypertension due to pre-eclamptic toxaemia in thirty women. ( Philipp, E, 1980) |
| " Twenty-two patients with moderately severe essential hypertension were treated for a period of 12 months with guanfacine (BS 100-141), a new centrally-acting antihypertensive agent." | 5.05 | Evaluation of long-term treatment of essential hypertension with guanfacine. ( Higuchi, M; Overlack, A; Stumpe, KO, 1980) |
| "Guanfacine, a new centrally acting alpha-mimetic antihypertensive drug, was given to two groups of 7 patients each, one with essential and the other with renal hypertension." | 5.05 | [Haemodynamic investigations with the new antihypertensive drug guanfacine (author's transl)]. ( Raschig, A; Rauh, J; Rosenthal, J; Schäfer, N, 1980) |
| "The antihypertensive and side effects of guanfacine and clonidine were compared in 24 patients with essential hypertension in a single-blind crossover study." | 5.05 | Evaluation of guanfacine and clonidine in essential hypertension: a single-blind crossover study. ( Louis, WJ; Miach, PJ, 1980) |
| " The antihypertensive effects of the new phenylacetylguanidine compound, guanfacine, a sympathetic inhibitor with a central site of action, were compared with methyldopa in 20 out-patients with essential or renal hypertension (WHO grade I-II)." | 5.05 | Comparative studies of guanfacine and methyldopa. ( Heidland, A; Roeckel, A, 1980) |
| "Control of hypertension (ie, reduction of blood pressure to less than or equal to 160/90 mmHg) in 40 mild to moderate hypertensives not responding adequately to hydrochlorothiazide was achieved by the addition of guanfacine (once daily) or methyldopa (twice daily) in a 16-week, double-blind, parallel-group trial." | 5.05 | Comparison of once-daily guanfacine and twice-a-day methyldopa in the treatment of mild to moderate hypertension. ( Bouchard, S; Brookman, S; Farooki, MS; Farsky, K; Lalonde, Y, 1985) |
| " Twenty patients with essential hypertension were treated with guanfacine given in single daily doses of 1--5 mg over a period of 24 weeks." | 5.05 | Antihypertensive effect of guanfacine: long-term 'once-a-day' treatment and sudden withdrawal. ( Holló, J; Szám, I, 1981) |
| " Drugs that enhance central alpha 2 activity, such as clonidine, guanfacine and the active metabolite of methyldopa, can significantly lower BP and are effective in the long-term control of hypertension, either alone or in combination with other drugs." | 4.77 | Alpha-adrenergic receptors and blood pressure control. ( Reid, JL, 1986) |
| "A 16-year-old female with Tourette's syndrome presented with diaphoresis, dry mouth, and hypertension 8 h after ingesting 25 mg of guanfacine." | 3.76 | Guanfacine overdose resulting in initial hypertension and subsequent delayed, persistent orthostatic hypotension. ( Clark, RF; Minns, AB; Schneir, A, 2010) |
| "30 patients with hypertension and diabetes mellitus type II were treated with guanfacine (Estulic--"Sandoz" Switzerland) 1 mg tablets in the course of 6 months." | 3.68 | [Guanfacine in the treatment of arterial hypertension in diabetics]. ( Belovezhdov, N; Daskalova, I; Monova, D, 1990) |
| "During three-month therapy with small doses of guanfacine (Estulic Sandoz) that were sufficient to control blood pressure in patients with stage II essential hypertension and led to a decrease in excretion of noradrenaline and vanillylmandelic acid, the authors found a decrease in the level of blood cholesterol in patients with hyperlipidaemia." | 3.67 | The effect of small doses of guanfacine (Estulic Sandoz) on the lipid levels and catecholamine excretion in patients with essential hypertension. ( Balazovjech, I; Kratochvíl'ová, H; Mikulecký, M; Skultétyová, D, 1987) |
| "More than 5,000 primary-care physicians enrolled more than 22,000 patients with mild to moderate hypertension in a postmarketing study in which guanfacine hydrochloride, a centrally acting antihypertensive agent, was given for 28 days." | 3.67 | A postmarketing evaluation of guanfacine hydrochloride in mild to moderate hypertension. ( Board, AW; Carchman, SH; Nyman, CE; Perry, VP; Shepperson, BE, 1988) |
| "The centrally acting alphamimetic antihypertensive drug, guanfacine, was studied in normotensive volunteers and patients with essential and renal hypertension." | 3.67 | Hemodynamic and endocrine responses to guanfacine in normotensive volunteers and hypertensive patients. ( Rosenthal, JH, 1986) |
| "The effect of guanfacine and hydrallazine on cardiovascular haemodynamics and on sympathetic nervous activity has been studied in 16 patients with essential hypertension." | 3.67 | Systemic and cardiac haemodynamic interactions between guanfacine and hydrallazine in hypertensive patients. ( Hernández, E; Hernández-Pieretti, O; Morillo, J; Ramirez, A; Urbina-Quintana, A; Velasco, M; Vizcarrondo, H, 1984) |
| "The effect of single-dose, short-term (6 weeks) and long-term (7 years) guanfacine therapy on various endocrine and metabolic parameters was evaluated in patients with moderate essential hypertension (WHO phase I and II)." | 3.67 | Effects of guanfacine on growth hormone, prolactin, renin, lipoproteins and glucose in essential hypertension. ( Balossi, EC; Hauger-Klevene, JH; Scornavacchi, JC, 1986) |
| "Hemodynamic evaluation of three men and eight women aged 20 to 58 years (mean, 44 years) with essential hypertension was performed before and after a single dose of guanfacine and before and after long-term administration of the drug, which is a stimulant of central alpha-adrenergic receptors." | 3.67 | Hemodynamic effects of guanfacine in essential hypertension. ( Burucúa, JE; Cohen, AA; Feldstein, CA; Sabaris, RP, 1984) |
| "The left ventricular end systolic stress-end systolic dimension (ESS-ESD) relation was used to assess the effect of regression in left ventricular hypertrophy on myocardial contractility in 14 hypertensive patients (mean age 47 years) treated with guanfacine (a sympatholytic central alpha-adrenergic agonist) for 10 weeks." | 3.67 | Contractile performance following regression of left ventricular hypertrophy in hypertensive patients. ( el-Said, G; Emile, H; Ibrahim, MM; Madkour, MA, 1985) |
| " Guanfacine (2 to 6 mg/day), a selective alpha 2-adrenoceptor agonist, decreased blood pressure in patients with hypertension." | 3.67 | Concentration-dependent blood pressure effects of guanfacine. ( Frisk-Holmberg, M; Wibell, L, 1986) |
| "The evolution of blood pressure, heart rate, epinephrine, norepinephrine, angiotensin II and plasma renin activity has been studied in 10 patients with essential arterial hypertension before and during a two months period of treatment with guanfacine, a new centrally acting hypotensive drug." | 3.67 | Relationships between blood pressure, heart rate and plasma epinephrine, norepinephrine, angiotensin II concentrations, plasma renin activity during chronic guanfacine therapy in patients with essential arterial hypertension. ( Collart, F; Staroukine, M; Verniory, A, 1985) |
| "The effect of short-term (6 weeks) and long-term (7 years) guanfacine treatment on some metabolic and endocrine parameters was studied in patients with moderate hypertension." | 3.67 | Prolactin, renin, growth hormone, lipoproteins and glucose under guanfacine treatment. ( Balossi, EC; Hauger-Klevene, JH; Scornavacchi, JC, 1987) |
| "The clinical pharmacology of a central antihypertensive drug, guanfacine, was studied in sustained essential hypertension." | 3.66 | [Clinical pharmacology of the antihypertensive action of guanfacine]. ( Georges, D; Safar, M; Weiss, Y, 1980) |
| "Twenty patients with essential hypertension were treated with guanfacine given in single 1-5 mg daily doses over a period of 24 weeks." | 3.66 | Long-term antihypertensive therapy with guanfacine. ( Holló, J; Szám, I, 1982) |
| " The acute and chronic effects of guanfacine on blood pressure, plasma noradrenaline concentration and plasma renin activity were investigated in 23 patients (15 males, 8 females) with essential hypertension (WHO grade I-II)." | 3.66 | Guanfacine in essential hypertension: effect on blood pressure, plasma noradrenaline concentration and plasma renin activity. ( Brecht, HM; Schoeppe, W, 1980) |
| "The effects of oral guanfacine were examined in six patients with essential hypertension." | 3.66 | Effects of single and multiple doses of guanfacine in essential hypertension. ( Reid, JL; Zamboulis, C, 1980) |
| "Estulic (guanfacine), a new centrally acting antihypertensive agent derived from guanidine, was administered to 13 patients with established essential hypertension." | 3.66 | [Estulic in the long-term treatment of hypertension]. ( Rhomberg, F, 1980) |
| "Guanfacine monotherapy was again shown to be an effective initial treatment for mild essential hypertension with no adverse influence on serum lipids." | 2.66 | Guanfacine as monotherapy for systemic hypertension. ( Blackshear, JL; Fillingim, JM; Strauss, A; Strauss, M, 1986) |
| " Guanfacine, alone and in combination, proved safe and effective." | 2.66 | Long-term evaluations of therapeutic efficacy and safety of guanfacine. ( Jerie, P, 1986) |
| "When guanfacine was tried in 6 very severe hypertensives who had proved resistant to other antihypertensive drugs, a similar reduction in diastolic pressure of 7 mmHg was achieved using a dose of 3 mg daily." | 2.65 | Guanfacine: a new centrally-acting antihypertensive agent. ( Beevers, DG; Bloxham, CA; Walker, JM, 1981) |
| "The results of one year's treatment of 243 hypertensive patients with guanfacine, given alone in a variety of doses and dosage schedules, were analyzed in terms of antihypertensive efficacy and incidence of side effects." | 2.65 | Guanfacine in the treatment of hypertension: two years' experience with low dose monotherapy. ( Jerie, P; Lasance, A, 1981) |
| "5." | 2.65 | Effect of guanfacine on blood pressure and renin activity in hypertensive patients. ( Rosenthal, J, 1980) |
| " The principal disadvantages of this class of medications are an overlap between the therapeutic dosage and that producing sedation and dry mouth and the potential to cause the discontinuation syndrome and sexual dysfunction." | 2.38 | Use of centrally acting sympatholytic agents in the management of hypertension. ( Epstein, M; Oster, JR, 1991) |
| "Guanfacine has the advantage over other centrally acting antihypertensives of being less sedative and causing no rebound hypertension after discontinuation of treatment." | 2.37 | Animal pharmacology of guanfacine. ( Scholtysik, G, 1986) |
| "Guanfacine monotherapy was effective in 75% of patients with moderate hypertension (using low doses 1-3 mg/day)." | 1.28 | [Hypotensive and hemodynamic effects of guanfacine in arterial hypertension]. ( Beliakova, EV; Charyev, KhZ; Erina, EV; Panfilov, VV, 1989) |
| "Guanfacine was more effective in controlling blood pressure than methyldopa, but it induced a slightly higher incidence of side-effects." | 1.27 | Comparison of antihypertensive activity and tolerability of guanfacine and methyldopa. ( Ambrosioni, E; Magnani, B; Malini, PL; Strocchi, E, 1983) |
| " The results on efficacy and dosage after 5-7 years were identical with those obtained for the entire group after 1 year (n = 580) and 2 years (n = 162)." | 1.27 | Long-term efficacy and tolerance of the antihypertensive agent guanfacine. ( Jerie, P; Lasance, A, 1984) |
| " Its kinetics were best described by a 2-compartment model, with an elimination half-life of the beta phase of 17 hours." | 1.27 | Pharmacokinetics of guanfacine in patients with impaired renal function and in some elderly patients. ( Kiechel, JR, 1986) |
| " The principal pharmacokinetic parameters of guanfacine were greatly altered, with extended biotransformation and a decrease in the half-life compared to the values observed in other cases of severe renal insufficiency." | 1.27 | Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure. ( Comoy, E; Fillastre, JP; Godin, M; Guerret, M; Kiechel, JR; Lavene, D, 1983) |
| " Guanfacine in once-daily dosage reduced BP during rest (supine BP: control, 175 +/- 6/103 +/- 4 mm Hg; 1 yr guanfacine, 161 +/- 5/91 +/- 3 mm Hg)." | 1.27 | Guanfacine in essential hypertension: effects during rest and isometric exercise. ( Hedner, T; Mellstrand, T; Nyberg, G, 1984) |
| " On the other hand, long-term administration of guanfacine at a dose of approximately 3 mg/kg/day produced a significant hypotension." | 1.26 | Effects of abrupt cessation of treatment with clonidine and guanfacine on blood pressure and heart rate in spontaneously hypertensive rats. ( Koike, Y; Saito, H; Shimamura, K; Togashi, H; Yomaida, I, 1981) |
| "Guanfacine treatment is accompanied by relatively few and slight side-effects." | 1.26 | [Blood pressure and renin under treatment of hypertension with guanfacine (author's transl)]. ( Jäger, H; Rosenthal, J, 1980) |
| " The vasodepressor effect of guanfacine was clearly dose-dependent, and was more marked when the initial level of the blood pressure was high, while that of clonidine was dose-dependent, only within a limited dosage range." | 1.26 | [Antihypertensive effect of guanfacine in rats]. ( Hamamura, M; Hashimoto, T; Imai, S; Kumada, M; Mitomi, A; Nakagawa, Y; Sakurai, H; Takeda, K, 1981) |
| "Guanfacine treated SHR showed less change in water drinking behavior and ambulation than the clonidine treated SHR." | 1.26 | Effects of clonidine and guanfacine on drinking and ambulation in spontaneously hypertensive rats. ( Bando, Y; Koike, Y; Minami, M; Saito, H; Shimamura, K; Togashi, H, 1982) |
| "5." | 1.26 | Guanfacine: effects of long-term treatment and withdrawal. ( Hamilton, CA; Reid, JL; Zamboulis, C, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 126 (81.29) | 18.7374 |
| 1990's | 19 (12.26) | 18.2507 |
| 2000's | 3 (1.94) | 29.6817 |
| 2010's | 5 (3.23) | 24.3611 |
| 2020's | 2 (1.29) | 2.80 |
| Authors | Studies |
|---|---|
| Cortese, S | 1 |
| Miyoshi, T | 1 |
| Mizushima, C | 1 |
| Noborio, Y | 1 |
| Kimoto, Y | 1 |
| Nakaharu, Y | 1 |
| Shimamoto, S | 1 |
| Luber, MJ | 1 |
| Coffey, BJ | 1 |
| Gamms, SH | 1 |
| Anderson, PO | 1 |
| Fontane, E | 1 |
| Shiber, J | 1 |
| Minns, AB | 1 |
| Clark, RF | 1 |
| Schneir, A | 1 |
| Bakris, GL | 1 |
| Lindholm, LH | 1 |
| Black, HR | 1 |
| Krum, H | 1 |
| Linas, S | 1 |
| Linseman, JV | 1 |
| Arterburn, S | 1 |
| Sager, P | 1 |
| Weber, M | 1 |
| Takishita, S | 1 |
| Yamazato, M | 1 |
| Sica, DA | 1 |
| van der Merwe, CJ | 1 |
| Kruger, SA | 1 |
| Salzmann, R | 1 |
| Gerber, W | 1 |
| Pally, C | 1 |
| Scholtysik, G | 3 |
| Joshi, RC | 1 |
| De, A | 1 |
| Cameron, EG | 1 |
| Van Zwieten, PA | 3 |
| Timmermans, PB | 2 |
| Van Brummelen, P | 1 |
| Lancranjan, I | 1 |
| Holzgreve, H | 1 |
| Saameli, K | 1 |
| Jerie, P | 6 |
| Seedat, YK | 3 |
| Schäfer, N | 3 |
| Knaup, G | 2 |
| Rahn, KH | 2 |
| Dorow, P | 1 |
| Koaté, P | 1 |
| Diouf, S | 1 |
| Sylla, M | 1 |
| Sarr, M | 1 |
| Ba, SA | 1 |
| Kiechel, JR | 2 |
| Lavene, D | 1 |
| Guerret, M | 1 |
| Comoy, E | 1 |
| Godin, M | 1 |
| Fillastre, JP | 1 |
| Hedner, T | 1 |
| Nyberg, G | 1 |
| Mellstrand, T | 1 |
| Lasance, A | 2 |
| Feldstein, CA | 1 |
| Cohen, AA | 1 |
| Sabaris, RP | 1 |
| Burucúa, JE | 1 |
| Malini, PL | 3 |
| Strocchi, E | 3 |
| Ambrosioni, E | 3 |
| Magnani, B | 3 |
| Lifshits, NL | 1 |
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| Rozhdestvenskaia, TM | 1 |
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| Panasiuk, VV | 1 |
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| Alföldi, S | 1 |
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| Togashi, H | 4 |
| Minami, M | 3 |
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| Shimamura, K | 3 |
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| Kurosawa, M | 1 |
| Kobayashi, T | 1 |
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| Román, O | 1 |
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| Rosenthal, J | 4 |
| Jäger, H | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 3 Randomized, Double-Blind, Placebo- and Active-Controlled, Multi-center, Parallel Group Study to Evaluate the Safety and Efficacy of Darusentan in Subjects With Resistant Hypertension Receiving Combination Therapy With Three or More Antihypertens[NCT00389779] | Phase 3 | 849 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for guanfacine and Blood Pressure, High
| Article | Year |
|---|---|
Pharmacologic Treatment of Attention Deficit-Hyperactivity Disorder.
Topics: Adolescent; Adult; Amphetamines; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperact | 2020 |
[Centrally-acting antihypertensive drugs].
Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Guanabenz; Guanfacine; Humans; Hypertension; Imi | 2004 |
Centrally acting antihypertensive agents: an update.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Pressure; Clonidine; Contraindications; Gu | 2007 |
Role of alpha adrenoceptors in hypertension and in antihypertensive drug treatment.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Azepines; | 1984 |
[Centrally acting sympathetic inhibitors for therapy of patients with hypertension].
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Fibers; Antihypertensive Agents; Clonidine; Guanfac | 1997 |
[The new antihypertensive preparation guanfacine (Estulic)].
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Drug Evaluation; Drug Evaluation, Preclin | 1992 |
Use of centrally acting sympatholytic agents in the management of hypertension.
Topics: Aged; Clonidine; Guanfacine; Heart; Humans; Hypertension; Kidney; Methyldopa; Sympatholytics | 1991 |
Guanfacine: a second generation alpha 2-adrenergic blocker.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Guanfacine; Guanidines; Humans; Hypertension; | 1990 |
Clinical pharmacology of centrally acting antihypertensive agents.
Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Guanfacine; Gu | 1989 |
Alpha-adrenergic receptors and blood pressure control.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Drug Ev | 1986 |
Animal pharmacology of guanfacine.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cats; Dogs; Dopamine; Drug Evaluation, Preclinical | 1986 |
Antihypertensive treatment in mild hypertension, its problems and future trends.
Topics: Antihypertensive Agents; Blood Pressure; Coronary Disease; Forecasting; Guanfacine; Guanidines; Huma | 1987 |
Guanfacine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension.
Topics: Blood Pressure; Disease; Drug Interactions; Endocrine Glands; Guanfacine; Guanidines; Hemodynamics; | 1986 |
Clonidine and guanfacine--comparison of their effects on haemodynamics in hypertension.
Topics: Blood Pressure; Cardiac Output; Clonidine; Epinephrine; Guanfacine; Guanidines; Hemodynamics; Humans | 1985 |
64 trials available for guanfacine and Blood Pressure, High
| Article | Year |
|---|---|
Divergent results using clinic and ambulatory blood pressures: report of a darusentan-resistant hypertension trial.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Endothelin Rec | 2010 |
The antihypertensive effect of guanfacine compared with methyldopa.
Topics: Adrenergic alpha-Agonists; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; | 1980 |
A comparative study of a new alpha-adrenoceptor agonist, guanfacine and alpha-methyldopa in the treatment of hypertension.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Female; G | 1984 |
Guanfacine alone and in combination therapy in the treatment of moderate and severe hypertension.
Topics: Antihypertensive Agents; Benzothiadiazines; Clinical Trials as Topic; Diuretics; Drug Therapy, Combi | 1983 |
[Antihypertensive therapy with guanfacine. A multicenter study with Estulic-Wander 1mg. Determinants of effectiveness and tolerance].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Female; Guanfacine; | 1983 |
Effects of clonidine and guanfacine in essential hypertension.
Topics: Adult; Blood Pressure; Cardiac Output; Clonidine; Guanfacine; Guanidines; Heart Rate; Humans; Hypert | 1984 |
[Guanfacine (Estulic) in the monotherapy of essential hypertension, grades I and II, according to WHO].
Topics: Adult; Antihypertensive Agents; Clinical Trials as Topic; Female; Guanfacine; Guanidines; Humans; Hy | 1984 |
[Treatment of arterial hypertension with a single daily dose of guanfacine].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Female; Guanfacine; | 1984 |
[Guanfacine in primary arterial hypertension: a long-term open clinical study].
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combinatio | 1982 |
An ambulatory trial of guanfacine.
Topics: Adult; Aged; Ambulatory Care; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Clinical Tr | 1980 |
Acute action of guanfacine on peripheral circulation in hypertensive patients: measurements of arterial flow of the calf and of the forefoot, of venous capacity of the calf, of the blood pressure and of the heart rate.
Topics: Adult; Antihypertensive Agents; Arteries; Blood Circulation; Blood Pressure; Dose-Response Relations | 1980 |
Haemodynamic effects of guanfacine.
Topics: Antihypertensive Agents; Blood Pressure; Cardiac Output; Clinical Trials as Topic; Guanfacine; Guani | 1980 |
Guanfacine in the treatment of hypertension due to pre-eclamptic toxaemia in thirty women.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Female; Guanfacine; Guanid | 1980 |
Effect of guanfacine on vigilance.
Topics: Adult; Antihypertensive Agents; Attention; Blood Pressure; Female; Guanfacine; Guanidines; Heart Rat | 1980 |
Clinical experience with guanfacine in long-term treatment of hypertension.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Diuretic | 1980 |
Antihypertensive effect of guanfacine: a double-blind cross-over trial compared with clonidine.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as To | 1980 |
Comparative studies of guanfacine and methyldopa.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Female; Guanfacine; Guanid | 1980 |
Long-term treatment of hypertension with guanfacine alone and in combination therapy.
Topics: Adult; Antihypertensive Agents; Clinical Trials as Topic; Drug Therapy, Combination; Female; Guanfac | 1980 |
Evaluation of long-term treatment of essential hypertension with guanfacine.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Diuretics; Epinephrine; Fe | 1980 |
Comparison of guanfacine and clonidine as antihypertensive agents.
Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Female; Guanfacine; Guanidines; Humans; Hyperten | 1980 |
Hypotensive effect of guanfacine in essential hypertension: a comparison with clonidine.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Clonidine; Guanfacine; Gua | 1980 |
Experiences with guanfacine in a two-year follow-up study.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Female; Follow-Up Studies; | 1980 |
Comparative study of two antihypertensive agents: guanfacine and guanethidine.
Topics: Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Female; Guanethidine; Guanfacine; | 1980 |
Effect of guanfacine on blood pressure and renin activity in hypertensive patients.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Female; Guanfacine; | 1980 |
Long term comparative study of guanfacine and alpha-methyldopa in essential hypertension.
Topics: Age Factors; Antihypertensive Agents; Blood Pressure; Body Height; Body Surface Area; Body Weight; D | 1980 |
[A new antihypertensive agent used in a clinical setting].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Bl | 1980 |
[Haemodynamic investigations with the new antihypertensive drug guanfacine (author's transl)].
Topics: Adult; Antihypertensive Agents; Cardiac Output; Drug Evaluation; Female; Guanfacine; Guanidines; Hea | 1980 |
Evaluation of guanfacine and clonidine in essential hypertension: a single-blind crossover study.
Topics: Blood Pressure; Clinical Trials as Topic; Clonidine; Guanfacine; Guanidines; Humans; Hypertension; P | 1980 |
Double-blind trial comparing guanfacine and methyldopa in patients with essential hypertension.
Topics: Antihypertensive Agents; Clinical Trials as Topic; Double-Blind Method; Guanfacine; Guanidines; Huma | 1981 |
Guanfacine: a new centrally-acting antihypertensive agent.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Female; | 1981 |
[Comparative study of the antihypertensive effect of guanfacine and guanethidine].
Topics: Clinical Trials as Topic; Guanethidine; Guanfacine; Guanidines; Humans; Hypertension; Phenylacetates | 1981 |
Guanfacine in the treatment of hypertension: two years' experience with low dose monotherapy.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Drug Administration Schedu | 1981 |
Antihypertensive effect of guanfacine: long-term 'once-a-day' treatment and sudden withdrawal.
Topics: Adult; Aged; Antihypertensive Agents; Drug Administration Schedule; Female; Guanfacine; Guanidines; | 1981 |
[Guanfacine versus alpha-methyldopa in benign essential hypertension. An ambulatory group study].
Topics: Adolescent; Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind M | 1981 |
[Clinical trial of a new antihypertensive preparation: guanfacine].
Topics: Adult; Aged; Clinical Trials as Topic; Female; Guanfacine; Guanidines; Humans; Hypertension; Male; M | 1979 |
[Estulic (guanfacine) in the treatment of arterial hypertension].
Topics: Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Female; Guanfacine; Heart; Hemodynam | 1992 |
Estulic--a well tolerated and effective antihypertensive drug in general practice.
Topics: Adult; Aged; Blood Pressure; Drug Therapy, Combination; Family Practice; Guanfacine; Humans; Hyperte | 1992 |
Estulic monotherapy and combined antihypertensive therapy.
Topics: Aged; Blood Pressure; Drug Therapy, Combination; Female; Guanfacine; Humans; Hypertension; Male | 1991 |
Antihypertensive efficacy of guanfacine and methyldopa in patients with mild to moderate essential hypertension.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Chlorthalidone; Double-Blind Method; Drug Therapy, C | 1991 |
[Circadian changes in arterial blood pressure and hemodynamics and the morphofunctional state of the myocardium in patients with hypertension during long-term treatment with estulic].
Topics: Adult; Aged; Blood Pressure; Circadian Rhythm; Clinical Trials as Topic; Female; Guanfacine; Guanidi | 1990 |
Antihypertensive efficacy of guanfacine and prazosin in patients with mild to moderate essential hypertension.
Topics: Adult; Blood Pressure; Double-Blind Method; Drug Evaluation; Female; Guanfacine; Humans; Hypertensio | 1990 |
Isradipine in essential hypertension: the Belgian General Practitioners' Study.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Antihypertensive Agents; Belgium; Blood Pressure; Calcium Ch | 1989 |
Guanfacine for hypertension.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Clinical Trials as Topic; Diuretics; Drug Therap | 1987 |
Hemodynamic effects of loud noise before and after central sympathetic nervous stimulation.
Topics: Adrenergic alpha-Agonists; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Guanfacine; | 1987 |
[Guanfacine in the long-term treatment of arterial hypertension].
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Guanfacine; Guanidines; Humans; Hypertension; Middl | 1988 |
[Evaluation of the hypotensive effect of guanfacine].
Topics: Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Guanfacine; Guanidines; Humans; H | 1988 |
Non-invasive monitoring of ambulatory blood pressure and its variability in elderly hypertensive patients: effect of guanfacine.
Topics: Aged; Ambulatory Care; Antihypertensive Agents; Blood Pressure Determination; Clinical Trials as Top | 1987 |
Low dose guanfacine and methyldopa in mild essential hypertension. A multiple centre study.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Guanfacine; Guanidines; He | 1987 |
Long-term clinical experience with guanfacine.
Topics: Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Diabetic Angiopathies; Follow-Up | 1987 |
Guanfacine in the treatment of hypertensives with a pronounced response to exercise and diabetes mellitus.
Topics: Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabet | 1987 |
Small and large doses of guanfacine (Estulic Sandoz) in the treatment of hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Dose-Response Relati | 1987 |
A multicenter, randomized, double-blind dose-response evaluation of step-2 guanfacine versus placebo in mild to moderate hypertension.
Topics: Administration, Oral; Adult; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Double-Blind | 1986 |
Usefulness of low dose guanfacine, once a day, for 24-hour control of essential hypertension.
Topics: Administration, Oral; Adult; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Double-Blind | 1986 |
Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertension.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Evaluation; Fe | 1986 |
Guanfacine as monotherapy for systemic hypertension.
Topics: Adult; Aged; Aldosterone; Cholesterol; Clinical Trials as Topic; Double-Blind Method; Drug Evaluatio | 1986 |
Long-term evaluations of therapeutic efficacy and safety of guanfacine.
Topics: Blood Pressure; Clinical Trials as Topic; Drug Evaluation; Female; Guanfacine; Guanidines; Heart Rat | 1986 |
[Use of the hypotensive drug guanfacine in the treatment of patients with hypertension].
Topics: Adolescent; Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Dose-Response | 1986 |
[Extracardiac systemic pharmacodynamic effects of estulic (guanfacine)].
Topics: Adult; Clinical Trials as Topic; Female; Guanfacine; Guanidines; Hemodynamics; Humans; Hypertension; | 1987 |
Effect of guanfacine on ambulatory blood pressure and its variability in elderly patients with essential hypertension.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Guanfacine; Guanidines; Humans; | 1987 |
Clonidine and guanfacine in hypertension.
Topics: Adult; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evalua | 1985 |
Comparison of once-daily guanfacine and twice-a-day methyldopa in the treatment of mild to moderate hypertension.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug A | 1985 |
Improvement of glucose tolerance in hypertensive diabetic patients treated with guanfacine one year.
Topics: Adult; Antihypertensive Agents; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; | 1985 |
[Minimal useful dose of guanfacine in patients with essential hypertension].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Female; Guanfacine; Guanid | 1985 |
[Use of estulic in patients with arterial hypertension].
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Gua | 1985 |
77 other studies available for guanfacine and Blood Pressure, High
| Article | Year |
|---|---|
Efficacy of combination therapy with gabapentin and guanfacine for paroxysmal sympathetic hyperactivity following hypoxic encephalopathy: a case report.
Topics: Autonomic Nervous System Diseases; Gabapentin; Guanfacine; Humans; Hypertension; Hypoxia, Brain; Mal | 2021 |
Paradoxical Hypertensive Urgency in a Child After Initiation of Guanfacine.
Topics: Antihypertensive Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Guanfacine; Hum | 2017 |
Treating Hypertension During Breastfeeding.
Topics: Adult; Antihypertensive Agents; Breast Feeding; Clonidine; Contraindications; Female; Guanfacine; Gu | 2018 |
A somnolent 2-year-old boy with a hyperactive brother.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Attention Deficit Disorder with H | 2013 |
Guanfacine overdose resulting in initial hypertension and subsequent delayed, persistent orthostatic hypotension.
Topics: Adolescent; Adrenergic alpha-Agonists; Blood Pressure; Drug Overdose; Electrocardiography; Female; G | 2010 |
Effects of the vasodilator endralazine given with the antihypertensive agent guanfacine on heart rate and blood pressure of spontaneously hypertensive rats and normotensive dogs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dogs; Drug Therapy, Combination; Guanfacine; Guani | 1983 |
Effect of guanfacine on pituitary hormones in man.
Topics: Adrenocorticotropic Hormone; Adult; Antihypertensive Agents; Female; Follicle Stimulating Hormone; G | 1980 |
[Forum on hypertension. Part 5. New anti-hypertensive agents in the therapy of hypertension].
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Captopril; Diuretics; Enzyme Inhi | 1981 |
Guanfacine and other centrally acting drugs in antihypertensive therapy; pharmacological and clinical aspects.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; Cats; Dogs; Guanfacine; Guanidines; Humans; | 1982 |
[Clinical pharmacology of the newer antihypertensive agents].
Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Captopril; Guanfacine; Guanidines | 1983 |
[The centrally acting antihypertensive drug guanfacine. Effect on lung function and circulatory parameters in hypertensive patients with bronchial asthma].
Topics: Adult; Antihypertensive Agents; Asthma; Female; Guanfacine; Guanidines; Hemodynamics; Humans; Hypert | 1983 |
[The place of guanfacine in the treatment of essential arterial hypertension].
Topics: Adult; Aged; Female; Guanfacine; Guanidines; Humans; Hypertension; Male; Middle Aged; Phenylacetates | 1983 |
Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure.
Topics: Female; Guanfacine; Guanidines; Humans; Hypertension; Kidney Failure, Chronic; Kinetics; Middle Aged | 1983 |
Guanfacine in essential hypertension: effects during rest and isometric exercise.
Topics: Blood Pressure; Drug Evaluation; Epinephrine; Female; Guanfacine; Guanidines; Heart Rate; Humans; Hy | 1984 |
Long-term efficacy and tolerance of the antihypertensive agent guanfacine.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Drug Therapy, Combination; Drug Tolerance; Female; | 1984 |
Hemodynamic effects of guanfacine in essential hypertension.
Topics: Adult; Blood Pressure; Female; Follow-Up Studies; Guanfacine; Guanidines; Heart Rate; Hemodynamics; | 1984 |
Comparison of antihypertensive activity and tolerability of guanfacine and methyldopa.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Evaluation; Female; Guanfa | 1983 |
[Labetalol and guanfacine in the treatment of arterial hypertension in patients with chronic renal failure].
Topics: Adolescent; Adult; Antihypertensive Agents; Drug Therapy, Combination; Ethanolamines; Female; Guanfa | 1984 |
Guanfacine and clonidine: the effects on adrenal medullary function in spontaneously hypertensive rats.
Topics: Adrenal Glands; Adrenal Medulla; Animals; Blood Pressure; Catecholamines; Clonidine; Guanfacine; Gua | 1984 |
Systemic and cardiac haemodynamic interactions between guanfacine and hydrallazine in hypertensive patients.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Guanfacine; Guanidines; Hemodynamics; Humans; Hydral | 1984 |
Long-term antihypertensive therapy with guanfacine.
Topics: Adult; Aged; Blood Pressure; Electrocardiography; Female; Guanfacine; Guanidines; Heart Rate; Humans | 1982 |
[Recent antihypertensive agents].
Topics: Antihypertensive Agents; Guanfacine; Guanidines; Humans; Hypertension; Labetalol; Minoxidil; Phenyla | 1982 |
Effects of clonidine and guanfacine on drinking and ambulation in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Drinking Behavior; Guanfacine; Guanidin | 1982 |
Effect of guanethidine, clonidine and guanfacine on urinary catecholamine excretion in cold-stressed spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Catecholamines; Clonidine; Cold Temperature; Guanethidine; Guanfac | 1982 |
[Antihypertensive effect of guanfacine in rats].
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Consciousness; Decerebrate | 1981 |
[Anti-hypertensive effectiveness of guanfacine and methyldopa: comparison of groups of patients].
Topics: Adult; Female; Guanfacine; Guanidines; Humans; Hypertension; Male; Methyldopa; Middle Aged; Phenylac | 1982 |
[Anti-hypertensive efficacy of guanfacine and methyldopa: intra-patient comparison].
Topics: Adult; Female; Guanfacine; Guanidines; Humans; Hypertension; Male; Methyldopa; Middle Aged; Phenylac | 1982 |
[Blood pressure and renin under treatment of hypertension with guanfacine (author's transl)].
Topics: Adult; Aged; Antihypertensive Agents; Drug Evaluation; Female; Guanfacine; Guanidines; Heart Rate; H | 1980 |
[Clinical pharmacology of the antihypertensive action of guanfacine].
Topics: Adult; Antihypertensive Agents; Female; Guanfacine; Guanidines; Hemodynamics; Humans; Hypertension; | 1980 |
[Estulic in the long-term treatment of hypertension].
Topics: Adult; Blood Pressure; Fatigue; Female; Guanfacine; Guanidines; Humans; Hypertension; Long-Term Care | 1980 |
[Antihypertensive effectiveness of a guanfacine/clopamide combination].
Topics: Adult; Aged; Antihypertensive Agents; Clopamide; Double-Blind Method; Drug Therapy, Combination; Fem | 1982 |
Blood pressure, heart rate, catecholamines and plasma renin activity following institution and withdrawal of guanfacine treatment in moderate hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Catecholamines; Female; Guanfacine; Guanidines; Hear | 1980 |
Haemodynamics in hypertensive patients before and during guanfacine treatment.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cardiac Output; Clonidine; Female; Guanfacine; Guani | 1980 |
Acute and chronic renal effects of guanfacine in essential and renal hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Creatinine; Drug Therapy, Combination; Electrolytes; Glomer | 1980 |
Clinical experience with guanfacine in long-term treatment of hypertension. Part II: adverse reactions to guanfacine.
Topics: Antihypertensive Agents; Body Weight; Clonidine; Dose-Response Relationship, Drug; Drug Administrati | 1980 |
Effect of guanfacine on skills related to driving.
Topics: Adult; Antihypertensive Agents; Attention; Auditory Perception; Automobile Driving; Discrimination, | 1980 |
Guanfacine: effects of long-term treatment and withdrawal.
Topics: Antihypertensive Agents; Blood Pressure; Female; Guanfacine; Guanidines; Heart Rate; Humans; Hyperte | 1980 |
Guanfacine in essential hypertension: effect on blood pressure, plasma noradrenaline concentration and plasma renin activity.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Guanfacine; Guanidines; Heart Rate; Humans; | 1980 |
Lifelong antihypertensive therapy.
Topics: Antihypertensive Agents; Female; Guanfacine; Guanidines; Humans; Hypertension; Phenylacetates; Time | 1980 |
[Controlled doubleblind study on dose-effect relationship of guanfacine a long-acting hypotensive guanidine derivative (author's transl)].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind | 1980 |
Effects of single and multiple doses of guanfacine in essential hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Female; Guanfacine; Guani | 1980 |
Withdrawal of guanfacine after long-term treatment in essential hypertension. Observations on blood pressure and plasma and urinary noradrenaline.
Topics: Blood Pressure; Female; Guanfacine; Guanidines; Humans; Hypertension; Male; Middle Aged; Norepinephr | 1981 |
Effects of abrupt cessation of treatment with clonidine and guanfacine on blood pressure and heart rate in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Clonidine; Epinephrine; Guanfacine; Guanidines; Heart Rate; Hypertension; M | 1981 |
[New hypotensive drugs].
Topics: Antihypertensive Agents; Captopril; Drug Evaluation; Guanfacine; Guanidines; Humans; Hypertension; L | 1981 |
Guanfacine and clonidine: antihypertensive and withdrawal characteristics after continuous infusion and its interruption in the spontaneously hypertensive and normotensive rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Catheters, Indwelling; Clonidine; Guanfacine; Guan | 1982 |
[The treatment of hypertension patients with Estulic].
Topics: Adult; Antihypertensive Agents; Drug Evaluation; Echocardiography; Electrocardiography; Exercise Tes | 1996 |
Renal alpha 2a/d-adrenoceptor subtype function: Wistar as compared to spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Diuresis; Diuretics; Dose-Response Relationship, | 1997 |
[Hypotensive and anti-ischemic efficiency of estulic in course treatment of myocardial infarction complicated by essential hypertension].
Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Coronary Angiography; Coronary Circulation; Echoca | 1999 |
Testosterone dependence of salt-induced hypertension in Sabra rats and role of renal alpha(2)-adrenoceptor subtypes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Gene Expression Re | 2002 |
A comparison of guanfacine, bunazosin, atenolol and nadolol on blood pressure and plasma noradrenaline responses to cold pressor testing.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Atenolol; Blood Pressure; Cold Temperature; G | 1992 |
[The calcium antagonist isradipine (Lomir) in the treatment of patients with essential hypertension].
Topics: Adult; Aged; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Drug Tole | 1992 |
Antagonism of antihypertensive effect of guanfacine by tricyclic antidepressants.
Topics: Adult; Amitriptyline; Drug Interactions; Female; Guanfacine; Humans; Hypertension; Imipramine | 1991 |
[Guanfacine in the treatment of arterial hypertension in diabetics].
Topics: Adolescent; Adult; Aged; Blood Pressure; Diabetes Mellitus, Type 2; Drug Evaluation; Female; Guanfac | 1990 |
Use of tensiomin (captopril) in the antihypertensive treatment of haemodialysis patients.
Topics: Adult; Antihypertensive Agents; Captopril; Drug Therapy, Combination; Female; Guanfacine; Guanidines | 1990 |
The effect of chronic guanfacine administration on high plasma vasopressin levels in essential hypertension.
Topics: Aldosterone; Blood Pressure; Female; Guanfacine; Guanidines; Humans; Hypertension; Male; Middle Aged | 1990 |
Antihypertensive therapy with guanfacine induces elevated plasma growth hormone levels in diabetic patients.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Diab | 1989 |
[Hypotensive and hemodynamic effects of guanfacine in arterial hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Guanfacine; Guanidines; Hemodynamics; Humans; Hypertension; Mi | 1989 |
Contractile performance following regression of left ventricular hypertrophy in hypertensive patients.
Topics: Adult; Guanfacine; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Myocardia | 1985 |
Concentration-dependent blood pressure effects of guanfacine.
Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Blood Pressure; Dose-Response Relationshi | 1986 |
Overview of alpha 2-adrenoceptor agonists with a central action.
Topics: Adrenergic alpha-Agonists; Blood Pressure; Central Nervous System; Clonidine; Guanfacine; Guanidines | 1986 |
Is there a role for renal alpha 2-adrenoceptors in the pathogenesis of hypertension?
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Gluconeogenesis; Guanfacine; Guanidines; Hypertension | 1987 |
A postmarketing evaluation of guanfacine hydrochloride in mild to moderate hypertension.
Topics: Adult; Aged; Blood Pressure; Female; Guanfacine; Guanidines; Heart Rate; Humans; Hypertension; Male; | 1988 |
Examination of the antihypertensive action of long-term estulic (Egis-Sandoz) treatment.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Female; Guanfacine; Guanidines; Humans; Hyp | 1988 |
Prolactin, renin, growth hormone, lipoproteins and glucose under guanfacine treatment.
Topics: Antihypertensive Agents; Blood Glucose; Blood Pressure; Dose-Response Relationship, Drug; Female; Gr | 1987 |
Guanfacine (Estulic) in the treatment of hypertension.
Topics: Antihypertensive Agents; Guanfacine; Guanidines; Humans; Hypertension; Phenylacetates | 1987 |
Improved exercise performance of hypertensive patients treated with guanfacine (Estulic Sandoz).
Topics: Antihypertensive Agents; Blood Pressure; Exercise Test; Guanfacine; Guanidines; Heart Rate; Humans; | 1987 |
The effect of small doses of guanfacine (Estulic Sandoz) on the lipid levels and catecholamine excretion in patients with essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Catecholamines; Cholesterol; Dose-Response Relations | 1987 |
[A clinical study of guanfacine in the treatment of arterial hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Female; Guanfacine; Guanidines; Humans; Hypertension; Male; Mi | 1987 |
A symposium: Guanfacine--a new choice in centrally acting antihypertensive agents. October 5-6, 1984, Scottsdale, Arizona.
Topics: Antihypertensive Agents; Guanfacine; Guanidines; Humans; Hypertension; Phenylacetates | 1986 |
Pharmacokinetics of guanfacine in patients with impaired renal function and in some elderly patients.
Topics: Absorption; Acute Kidney Injury; Administration, Oral; Adult; Aged; Aging; Biological Availability; | 1986 |
Hemodynamic and endocrine responses to guanfacine in normotensive volunteers and hypertensive patients.
Topics: Administration, Oral; Adult; Blood Pressure; Cardiac Output; Drug Evaluation; Female; Guanfacine; Gu | 1986 |
Effects of guanfacine on growth hormone, prolactin, renin, lipoproteins and glucose in essential hypertension.
Topics: Administration, Oral; Adult; Blood Glucose; Blood Pressure; Cholesterol; Dose-Response Relationship, | 1986 |
[Improvement of the functional capacity of hypertensive patients treated with guanfacine].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Coronary Disease; Follow-Up Studies; Guanfacine; Gua | 1986 |
[Antihypertensive treatment with guanfacine in patients with type II diabetes mellitus].
Topics: Antihypertensive Agents; Diabetes Mellitus, Type 2; Female; Guanfacine; Guanidines; Humans; Hyperten | 1987 |
Relationships between blood pressure, heart rate and plasma epinephrine, norepinephrine, angiotensin II concentrations, plasma renin activity during chronic guanfacine therapy in patients with essential arterial hypertension.
Topics: Angiotensin II; Antihypertensive Agents; Blood Pressure; Epinephrine; Female; Guanfacine; Guanidines | 1985 |
Effects of clonidine and guanfacine on haemodynamics in hypertension.
Topics: Blood Pressure; Clonidine; Guanfacine; Guanidines; Humans; Hypertension; Phenylacetates | 1985 |
Improved glucose tolerance after guanfacine treatment in hypertensive diabetic (type II) patients: one year follow up.
Topics: Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Guanfacine; G | 1985 |