guanethidine has been researched along with Parkinson Disease in 3 studies
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This could be the explantion for the orthostatic hypotension found in patients taking L-dopa for Parkinsonism." | 2.63 | Action of dopamine on the human iris. ( Calne, DB; Spiers, AS, 1969) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hunter, KR | 1 |
| Stern, GM | 1 |
| Laurence, DR | 1 |
| Nelson, SR | 1 |
| Walaszek, EJ | 1 |
| Spiers, AS | 1 |
| Calne, DB | 1 |
1 review available for guanethidine and Parkinson Disease
| Article | Year |
|---|---|
Pharmacology of the central nervous system.
Topics: Abnormalities, Drug-Induced; Acetylcholine; Adrenocorticotropic Hormone; Amphetamine; Anger; Angiote | 1968 |
1 trial available for guanethidine and Parkinson Disease
| Article | Year |
|---|---|
Action of dopamine on the human iris.
Topics: Adult; Aged; Dihydroxyphenylalanine; Dilatation; Dopamine; Dopamine Antagonists; Female; Guanethidin | 1969 |
1 other study available for guanethidine and Parkinson Disease
| Article | Year |
|---|---|
Use of levodopa with other drugs.
Topics: Adult; Aged; Antidepressive Agents; Antiemetics; Digoxin; Dihydroxyphenylalanine; Diuretics; Drug An | 1970 |