guanethidine has been researched along with Nerve Degeneration in 16 studies
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To test the hypothesis that the enhanced sympathoexcitatory response to a high salt intake contributes to the development of hypertension in this model, newborn Wistar rats were given 50 mg/kg capsaicin and/or 80 mg/kg guanethidine subcutaneously." | 3.71 | Degeneration of capsaicin-sensitive sensory nerves leads to increased salt sensitivity through enhancement of sympathoexcitatory response. ( Lookingland, KJ; Wang, DH; Wu, W, 2001) |
| "Guanethidine treatment of capsaicin-injected rats reversed the loss of calcitonin gene-related peptide-immunoreactive nerves, but not that of substance P-immunoreactive neurons." | 1.28 | Plasticity in expression of calcitonin gene-related peptide and substance P immunoreactivity in ganglia and fibres following guanethidine and/or capsaicin denervation. ( Burnstock, G; Cavanagh, JF; Kirkpatrick, KA; Mione, MC, 1992) |
| "The chronic administration of guanethidine causes an immune-mediated destruction of sympathetic neurons in rats." | 1.27 | Protection from guanethidine-induced neuronal destruction by nerve growth factor: effect of NGF on immune function. ( Johnson, EM; Manning, PT; Russell, JH; Simmons, B, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Walters, KM | 1 |
| Boucher, M | 1 |
| Boucher, GG | 1 |
| Opsahl, AC | 1 |
| Mouton, PR | 1 |
| Liu, CN | 1 |
| Ritenour, CR | 1 |
| Kawabe, TT | 1 |
| Pryski, HN | 1 |
| Somps, CJ | 1 |
| Archakova, LI | 1 |
| Bulygin, IA | 1 |
| Nozdrachev, AD | 1 |
| Shilkin, VV | 1 |
| Accuratov, EG | 1 |
| Worobjeva, OB | 1 |
| Obraschikova, MN | 1 |
| Rumjanceva, TA | 1 |
| Filimonov, VJ | 1 |
| Sabanov, VS | 1 |
| Wang, DH | 1 |
| Wu, W | 1 |
| Lookingland, KJ | 1 |
| Johnson, EM | 2 |
| Macia, RA | 1 |
| Andres, RY | 1 |
| Bradshaw, RA | 1 |
| Mione, MC | 1 |
| Cavanagh, JF | 1 |
| Kirkpatrick, KA | 1 |
| Burnstock, G | 4 |
| Kidd, GJ | 2 |
| Heath, JW | 5 |
| Trapp, BD | 1 |
| Dunkley, PR | 2 |
| Schmidt, RE | 1 |
| Summerfield, AL | 1 |
| Hickey, WF | 1 |
| Koistinaho, J | 1 |
| Hervonen, A | 1 |
| Manning, PT | 1 |
| Russell, JH | 1 |
| Simmons, B | 1 |
| Sluka, BA | 1 |
| Evans, BK | 2 |
| Hill, CE | 1 |
| Gannon, BJ | 1 |
| James, VB | 1 |
| Caramia, F | 1 |
| Ubaldo Angeletti, P | 1 |
| Levi-Montalcini, R | 1 |
| Carratelli, L | 1 |
16 other studies available for guanethidine and Nerve Degeneration
| Article | Year |
|---|---|
No Evidence of Neurogenesis in Adult Rat Sympathetic Ganglia Following Guanethidine-Induced Neuronal Loss.
Topics: Animals; Ganglia, Sympathetic; Guanethidine; Nerve Degeneration; Neurogenesis; Neurons; Rats; Sympat | 2020 |
[Ultrastructure of sensory endings in sympathetic ganglia].
Topics: Animals; Cats; Dendrites; Endoplasmic Reticulum; Ganglia, Sympathetic; Guanethidine; Microscopy, Ele | 1980 |
The changes in the nervous structures under the chemical sympathectomy with guanethidine.
Topics: Animals; Guanethidine; Motor Neurons; Muscle Denervation; Nerve Degeneration; Neuromuscular Junction | 1998 |
Degeneration of capsaicin-sensitive sensory nerves leads to increased salt sensitivity through enhancement of sympathoexcitatory response.
Topics: Animals; Animals, Newborn; Blood Pressure; Capsaicin; Female; Guanethidine; Hypertension; Injections | 2001 |
The effects of drug which destroy the sympathetic nervous system on the retrograde transport of nerve growth factor.
Topics: Animals; Animals, Newborn; Axonal Transport; Ganglia, Sympathetic; Guanethidine; Guanidines; Hydroxy | 1979 |
Plasticity in expression of calcitonin gene-related peptide and substance P immunoreactivity in ganglia and fibres following guanethidine and/or capsaicin denervation.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cerebral Arteries; Dura Mater; Ganglia; Gene Ex | 1992 |
Myelin sheath survival after guanethidine-induced axonal degeneration.
Topics: Animals; Axons; Ganglia, Sympathetic; Guanethidine; Male; Microscopy, Electron; Myelin Sheath; Nerve | 1992 |
Ultrastructural and immunohistologic characterization of guanethidine-induced destruction of peripheral sympathetic neurons.
Topics: Animals; Drug Resistance; Ganglia, Sympathetic; Guanethidine; Immunohistochemistry; Microscopy, Elec | 1990 |
Neuronal degeneration and lipopigment formation in rat sympathetic ganglion after treatment with high-dose guanethidine.
Topics: Animals; Catecholamines; Fluorometry; Ganglia, Sympathetic; Guanethidine; Lipid Metabolism; Lipid Pe | 1989 |
Protection from guanethidine-induced neuronal destruction by nerve growth factor: effect of NGF on immune function.
Topics: Animals; Guanethidine; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; M | 1985 |
[Structure of the neurons of the sympathetic ganglia in guanethidine chemical sympathectomy].
Topics: Animals; Ganglia, Sympathetic; Guanethidine; Microscopy, Electron; Nerve Degeneration; Neurons; Rats | 1987 |
Degeneration of myelinated sympathetic nerve fibres following treatment with guanethidine.
Topics: Adrenergic Fibers; Animals; Ganglia, Sympathetic; Guanethidine; Male; Microscopy, Electron; Nerve De | 1986 |
Axon retraction following guanethidine treatment. Studies of sympathetic neurons in vivo.
Topics: Animals; Axons; Cell Count; Fluorescence; Ganglia, Autonomic; Guanethidine; Histocytochemistry; Hydr | 1973 |
Axon retraction following guanethidine treatment: studies of sympathetic neurons in tissue culture.
Topics: Animals; Axons; Culture Techniques; Guanethidine; Microscopy, Phase-Contrast; Nerve Degeneration; Ne | 1974 |
Degeneration of adrenergic neurons following guanethidine treatment: an ultrastructural study.
Topics: Animals; Guanethidine; Hyperplasia; Male; Microscopy, Electron; Mitochondria; Nerve Degeneration; Ne | 1972 |
Mitochondrial lesions of developing sympathetic neurons induced by bretylium tosylate.
Topics: Animals; Animals, Newborn; Bretylium Compounds; Dopamine; Ganglia, Autonomic; Guanethidine; Microsco | 1972 |