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guanethidine and Hypoxia

guanethidine has been researched along with Hypoxia in 17 studies

Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
"We previously demonstrated that 7-d-old rat pups exposed to hypoxia from birth exhibit ACTH-independent increases in corticosterone associated with an increase in steroidogenic acute regulatory (StAR) and peripheral-type benzodiazepine receptor (PBR) proteins."7.72Basal and adrenocorticotropin-stimulated corticosterone in the neonatal rat exposed to hypoxia from birth: modulation by chemical sympathectomy. ( Engeland, WC; Lee, JJ; Oaks, MK; Raff, H; Widmaier, EP, 2004)
"In an attempt to understand the changes of circulating neuropeptide Y (NPY) during hypoxia, the plasma level of NPY was investigated by radioimmunoassay."7.68Increase of plasma neuropeptide Y-like immunoreactivity following chronic hypoxia in the rat. ( Chen, CF; Chen, HI; Cheng, JT; Shum, AY; Wang, JY, 1992)
"We previously demonstrated that 7-d-old rat pups exposed to hypoxia from birth exhibit ACTH-independent increases in corticosterone associated with an increase in steroidogenic acute regulatory (StAR) and peripheral-type benzodiazepine receptor (PBR) proteins."3.72Basal and adrenocorticotropin-stimulated corticosterone in the neonatal rat exposed to hypoxia from birth: modulation by chemical sympathectomy. ( Engeland, WC; Lee, JJ; Oaks, MK; Raff, H; Widmaier, EP, 2004)
"In an attempt to understand the changes of circulating neuropeptide Y (NPY) during hypoxia, the plasma level of NPY was investigated by radioimmunoassay."3.68Increase of plasma neuropeptide Y-like immunoreactivity following chronic hypoxia in the rat. ( Chen, CF; Chen, HI; Cheng, JT; Shum, AY; Wang, JY, 1992)
"In order to assess the status of dopamine in the periphery, we submitted rats to sympathectomy (with guanethidine), to hypoxia, and to both, and measured the concentration and turnover of noradrenaline and dopamine in peripheral organs."3.68Response of noradrenaline and dopamine to hypoxia and sympathectomy: evidence for an independent dopaminergic reactivity. ( Claustre, J; Cottet-Emard, JM; Dalmaz, Y; Pequignot, JM; Peyrin, L, 1992)
" The effects of severe arterial and primary tissue (carbon monoxide) hypoxia on cardiac output, arterial and right atrial pressures, heart rate and ventilation, have been studied in unanaesthetized normal rabbits, and in animals subjected to adrenalectomy, ;sympathectomy' (guanethidine), adrenalectomy + ;sympathectomy', and section of the carotid sinus and aortic nerves."3.64Circulatory control in hypoxia by the sympathetic nerves and adrenal medulla. ( Korner, PI; White, SW, 1966)
"Guanethidine treatment attenuated the hypoxia-induced increase in cholesterol ester-bound arachidonic and adrenic acids."1.33Adrenal lipid profiles of chemically sympathectomized normoxic and hypoxic neonatal rats. ( Bruder, ED; Henderson, LM; Raff, H, 2006)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199011 (64.71)18.7374
1990's4 (23.53)18.2507
2000's2 (11.76)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
HARRIS, P1
BISHOP, JM1
SEGEL, N1
TARDOS, L1
LESZKOVSZKY, G1
VOGEL, JH1
AVERILL, KH1
POOL, PE1
BLOUNT, SG1
MURRAY, JF1
PENNA, M1
LINARES, F1
CACERES, L1
Raff, H2
Lee, JJ1
Widmaier, EP1
Oaks, MK1
Engeland, WC1
Bruder, ED1
Henderson, LM1
Forsling, ML1
Aziz, LA1
McKenzie, JC1
Klein, RM1
Borghini, N1
Dalmaz, Y2
Peyrin, L2
Heym, C1
Cheng, JT1
Chen, CF1
Shum, AY1
Wang, JY1
Chen, HI1
Claustre, J1
Cottet-Emard, JM1
Pequignot, JM1
Koshelev, VB1
Kondashevskaia, MV1
Rodionov, IM1
Bowman, A1
McGrath, JC1
Mocavero, G1
Bennett, T1
Korner, PI1
White, SW1

Reviews

2 reviews available for guanethidine and Hypoxia

ArticleYear
SYSTEMIC CIRCULATION.
    Annual review of physiology, 1964, Volume: 26

    Topics: Aldosterone; Angiotensins; Blood Circulation; Blood Vessels; Blood Viscosity; Blood Volume; Blood Vo

1964
[Factors influencing hemodynamics during anesthesia].
    Minerva anestesiologica, 1968, Volume: 34, Issue:1

    Topics: Adrenal Cortex Hormones; Anesthesia; Carbon Dioxide; Catecholamines; Guanethidine; Hemodynamics; Hum

1968

Other Studies

15 other studies available for guanethidine and Hypoxia

ArticleYear
The influence of guanethidine on hypoxic pulmonary hypertension in normal man.
    Clinical science, 1961, Volume: 21

    Topics: Antihypertensive Agents; Guanethidine; Hypertension, Pulmonary; Hypoxia; Lung; Pulmonary Artery

1961
THE ROLE OF CATECHOLAMINES IN THE DEVELOPMENT OF MYOCARDIAL HYPOXIA.
    Archives internationales de pharmacodynamie et de therapie, 1963, Oct-01, Volume: 145

    Topics: Arginine Vasopressin; Catecholamines; Coronary Disease; Guanethidine; Hypoxia; Metabolism; Norepinep

1963
EXPERIMENTAL PULMONARY ARTERIAL HYPERTENSION IN THE NEWBORN CALF.
    Circulation research, 1963, Volume: 13

    Topics: Acetylcholine; Animals; Animals, Newborn; Atropine; Cattle; Guanethidine; Hypertension; Hypertension

1963
MECHANISM FOR CARDIAC STIMULATION DURING HYPOXIA.
    The American journal of physiology, 1965, Volume: 208

    Topics: Cardiotonic Agents; Catecholamines; Cats; Guanethidine; Guinea Pigs; Hypoxia; Muscle Contraction; My

1965
Basal and adrenocorticotropin-stimulated corticosterone in the neonatal rat exposed to hypoxia from birth: modulation by chemical sympathectomy.
    Endocrinology, 2004, Volume: 145, Issue:1

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Animals; Animals, Newborn; Body Weight; Ca

2004
Adrenal lipid profiles of chemically sympathectomized normoxic and hypoxic neonatal rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2006, Volume: 38, Issue:12

    Topics: Adrenal Glands; Animals; Animals, Newborn; Corticosterone; Female; Guanethidine; Hypoxia; Lipids; Pr

2006
Release of vasopressin in response to hypoxia and the effect of aminergic and opioid antagonists.
    The Journal of endocrinology, 1983, Volume: 99, Issue:1

    Topics: Animals; Arginine Vasopressin; Blood Pressure; Guanethidine; Heart Rate; Hypoxia; Levallorphan; Male

1983
The effect of neonatal guanethidine administration on hemodynamic and physical alterations in the adult rat pulmonary artery during the development of hypoxia-induced pulmonary hypertension.
    Journal of the autonomic nervous system, 1984, Volume: 10, Issue:2

    Topics: Animals; Animals, Newborn; Guanethidine; Hypertension, Pulmonary; Hypoxia; Pulmonary Artery; Rats; R

1984
Chemosensitivity, plasticity, and functional heterogeneity of paraganglionic cells in the rat coeliac-superior mesenteric complex.
    Microscopy research and technique, 1994, Oct-01, Volume: 29, Issue:2

    Topics: Animals; Dopamine; Ganglia, Sympathetic; Guanethidine; Hypoxia; Immunoenzyme Techniques; Male; Mesen

1994
Increase of plasma neuropeptide Y-like immunoreactivity following chronic hypoxia in the rat.
    Neuroscience letters, 1992, Jun-22, Volume: 140, Issue:2

    Topics: Adrenal Glands; Adrenalectomy; Animals; Blood Pressure; Bretylium Compounds; Chromatography, High Pr

1992
Response of noradrenaline and dopamine to hypoxia and sympathectomy: evidence for an independent dopaminergic reactivity.
    Journal of the autonomic nervous system, 1992, Volume: 38, Issue:1

    Topics: Animals; Dopamine; Guanethidine; Hypoxia; Male; Norepinephrine; Rats; Rats, Inbred Strains; Sympathe

1992
[Sympathetic nerves control the process of microvascular neogenesis induced by adaptation to hypoxia].
    Doklady Akademii nauk SSSR, 1990, Volume: 311, Issue:3

    Topics: Adaptation, Physiological; Animals; Animals, Newborn; Atmosphere Exposure Chambers; Capillaries; Cap

1990
The effect of hypoxia on neuroeffector transmission in the bovine retractor penis and rat anococcygeus muscles.
    British journal of pharmacology, 1985, Volume: 85, Issue:4

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Alprostadil; Animals; Cattle; Electric Stimulation; Guanethidine; G

1985
Nerve-mediated excitation and inhibition of the smooth muscle cells of the avian gizzard.
    The Journal of physiology, 1969, Volume: 204, Issue:3

    Topics: Action Potentials; Animals; Chickens; Columbidae; Electric Stimulation; Electrophysiology; Evoked Po

1969
Circulatory control in hypoxia by the sympathetic nerves and adrenal medulla.
    The Journal of physiology, 1966, Volume: 184, Issue:2

    Topics: Adrenal Medulla; Adrenalectomy; Animals; Aorta; Blood Pressure; Carotid Sinus; Catecholamines; Guane

1966