guanethidine has been researched along with Hypotension, Orthostatic in 31 studies
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Symptoms due to orthostatic and exertional hypotension occurred in 23-4 per cent of 448 hypertensive patients treated with guanethidine, debrisoquine, or bethanidine." | 3.65 | Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure. ( Smith, AJ; Talbot, S, 1975) |
| "This could be the explantion for the orthostatic hypotension found in patients taking L-dopa for Parkinsonism." | 2.63 | Action of dopamine on the human iris. ( Calne, DB; Spiers, AS, 1969) |
| "Clonidine has some central component for induction of postural hypotension in addition to the frequency-related peripheral component." | 1.28 | Evaluation of the central and peripheral components for induction of postural hypotension by guanethidine, clonidine, dopamine2 receptor agonists and 5-hydroxytryptamine1A receptor agonists. ( Cannon, JG; Long, JP; Park, KH, 1991) |
| "Postural hypotension is a common side effect observed in the treatment of hypertension with various drugs." | 1.27 | Evaluation of the risk for drug-induced postural hypotension in an experimental model: investigations with carvedilol, prazosin, labetalol, and guanethidine. ( Bartsch, W; Böhm, E; Hooper, RG; Sponer, G; Strein, K, 1987) |
| "Diarrhoea, impotence, failure of ejaculation, blurred vision, depression, and the symptoms of postural hypotension were not related to methyldopa therapy." | 1.25 | Side effects of hypotensive agents evaluated by a self-administered questionnaire. ( Bulpitt, CJ; Dollery, CT, 1973) |
| "Bethanidine is a potent sympathetic blocking agent in man with properties intermediate between those of bretylium and guanethidine." | 1.24 | THE EFFECTS OF BETHANIDINE ON THE PERIPHERAL CIRCULATION IN MAN. ( FEWINGS, JD; HODGE, RL; SCROOP, GC; WHELAN, RF, 1964) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (96.77) | 18.7374 |
| 1990's | 1 (3.23) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| RIPKA, O | 1 |
| MALIS, F | 1 |
| WALDSTEIN, SS | 1 |
| WEST, GH | 1 |
| LEE, WY | 1 |
| BRONSKY, D | 1 |
| BEWLEY, TH | 1 |
| FEWINGS, JD | 1 |
| HODGE, RL | 1 |
| SCROOP, GC | 1 |
| WHELAN, RF | 1 |
| DUSTAN, HP | 1 |
| PAGE, IH | 1 |
| Lee, CH | 1 |
| Strosberg, AM | 1 |
| Roszkowski, AP | 1 |
| Warren, LA | 1 |
| Goldberg, AD | 1 |
| Raftery, EB | 1 |
| Barker, LR | 2 |
| Talbot, S | 2 |
| Smith, AJ | 1 |
| Nolan, PL | 1 |
| Bentley, GA | 1 |
| Gill, GW | 1 |
| Park, KH | 1 |
| Long, JP | 1 |
| Cannon, JG | 1 |
| Bartsch, W | 1 |
| Sponer, G | 1 |
| Strein, K | 1 |
| Böhm, E | 1 |
| Hooper, RG | 1 |
| Kalmanovitch, DV | 1 |
| Hardwick, PB | 1 |
| Pals, DT | 1 |
| DeGraaf, GL | 1 |
| Lagrue, G | 1 |
| Weil, B | 1 |
| Buisson, C | 1 |
| Grunstein, JA | 1 |
| McNay, JL | 1 |
| Glezer, GA | 1 |
| Moskalenko, NP | 1 |
| Limas, CJ | 1 |
| Freis, ED | 1 |
| Kim, KE | 1 |
| Onesti, G | 1 |
| Swartz, C | 1 |
| Horwitz, D | 1 |
| Alexander, RW | 1 |
| Lovenberg, W | 1 |
| Keiser, HR | 1 |
| Bulpitt, CJ | 1 |
| Dollery, CT | 1 |
| Bauer, GE | 1 |
| Hull, RD | 1 |
| Stokes, GS | 1 |
| Raftos, J | 1 |
| Loggie, JM | 1 |
| Cuningham, JA | 1 |
| Oates, JA | 1 |
| Seligmann, AW | 1 |
| Clark, MA | 1 |
| Rousseau, P | 1 |
| Lee, RE | 1 |
| Spiers, AS | 1 |
| Calne, DB | 1 |
| Khatri, IM | 1 |
| Cohn, JN | 1 |
| Simonsen, B | 1 |
1 review available for guanethidine and Hypotension, Orthostatic
| Article | Year |
|---|---|
Hypertension in children and adolescents. II. Drug therapy.
Topics: Age Factors; Antihypertensive Agents; Blood Pressure Determination; Child; Chlorothiazide; Chronic D | 1969 |
2 trials available for guanethidine and Hypotension, Orthostatic
| Article | Year |
|---|---|
The relative efficacy of guanethidine, methyldopa and pargyline as antihypertensive agents.
Topics: Clinical Trials as Topic; Guanethidine; Humans; Hypertension; Hypotension, Orthostatic; Methyldopa; | 1965 |
Action of dopamine on the human iris.
Topics: Adult; Aged; Dihydroxyphenylalanine; Dilatation; Dopamine; Dopamine Antagonists; Female; Guanethidin | 1969 |
28 other studies available for guanethidine and Hypotension, Orthostatic
| Article | Year |
|---|---|
[GUANETHIDINE. A NEW TYPE HYPOTENSIVE DRUG].
Topics: Abdomen; Antihypertensive Agents; Bradycardia; Fundus Oculi; Guanethidine; Humans; Hypertension; Hyp | 1963 |
GUANETHIDINE IN HYPERTHYROIDISM.
Topics: Catecholamines; Drug Therapy; Guanethidine; Hyperthyroidism; Hypotension; Hypotension, Orthostatic; | 1964 |
TO-DAY'S DRUGS. BETHANIDINE SULPHATE.
Topics: Antihypertensive Agents; Bethanidine; Bretylium Compounds; Chemistry, Pharmaceutical; Depression; De | 1964 |
THE EFFECTS OF BETHANIDINE ON THE PERIPHERAL CIRCULATION IN MAN.
Topics: Antihypertensive Agents; Autonomic Nerve Block; Bethanidine; Blood Pressure; Blood Pressure Determin | 1964 |
SOME FACTORS IN RENAL AND RENOPRIVAL HYPERTENSION.
Topics: Blood; Blood Pressure; Blood Proteins; Blood Volume; Chlorothiazide; Cholesterol; Drug Therapy; Guan | 1964 |
A model for evaluation of postural hypotension induced by drugs in conscious restrained normotensive rats.
Topics: Anesthetics; Animals; Antihypertensive Agents; Consciousness; Disease Models, Animal; Guanethidine; | 1982 |
Patterns of blood-pressure during chronic administration of postganglionic sympathetic blocking drugs for hypertension.
Topics: Adult; Aged; Bethanidine; Blood Pressure; Circadian Rhythm; Debrisoquin; Female; Guanethidine; Guani | 1976 |
Guanethidine, exercise, and hypotension.
Topics: Guanethidine; Humans; Hypertension; Hypotension, Orthostatic; Physical Exertion | 1976 |
Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure.
Topics: Bethanidine; Cardiomegaly; Circadian Rhythm; Debrisoquin; Female; Guanethidine; Guanidines; Heart Ra | 1975 |
Studies on orthostatic cardiovascular responses in anaesthetized cats.
Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Bretylium Compounds; Cats; Clonidine; Guanethidine; | 1975 |
Guanethidine in the management of hypertension.
Topics: Guanethidine; Humans; Hypertension; Hypotension, Orthostatic | 1977 |
Exertional hypotension due to postganglionic sympathetic blocking drugs.
Topics: Bethanidine; Blood Pressure; Debrisoquin; Guanethidine; Guanidines; Heart Rate; Humans; Hypotension, | 1976 |
Evaluation of the central and peripheral components for induction of postural hypotension by guanethidine, clonidine, dopamine2 receptor agonists and 5-hydroxytryptamine1A receptor agonists.
Topics: Animals; Blood Pressure; Bradycardia; Cats; Central Nervous System; Clonidine; Female; Guanethidine; | 1991 |
Evaluation of the risk for drug-induced postural hypotension in an experimental model: investigations with carvedilol, prazosin, labetalol, and guanethidine.
Topics: Animals; Blood Pressure; Carbazoles; Carvedilol; Disease Models, Animal; Guanethidine; Hypotension, | 1987 |
Hypotension after guanethidine block.
Topics: Aged; Female; Guanethidine; Humans; Hypotension, Orthostatic; Nerve Block | 1988 |
Cardiovascular effects of losulazine hydrochloride, a peripheral norepinephrine-depleting agent, in nonhuman primates.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Chlorisondamine; Desipramine; Dose | 1985 |
[General principles of antihypertensive treatment].
Topics: Antihypertensive Agents; Cardiac Output; Clonidine; Follow-Up Studies; Ganglionic Blockers; Guanethi | 1974 |
The problem of postural hypotension.
Topics: Adrenergic beta-Antagonists; Aged; Dihydroxyphenylalanine; Diuretics; Female; Guanethidine; Humans; | 1974 |
Adrenolytic and vasodilator therapy.
Topics: Adrenergic beta-Antagonists; Benzyl Compounds; Blood Circulation; Cardiac Output; Clonidine; Diazoxi | 1974 |
[The effect of alpha-methyldopa and guanethidine on hemodynamic shifts in the orthostatic position in patients with arterial hypertension].
Topics: Adult; Blood Pressure; Blood Volume; Cardiac Output; Glomerulonephritis; Guanethidine; Heart; Heart | 1972 |
Minoxidil in severe hypertension with renal failure. Effect of its addition to conventional antihypertensive drugs.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Evaluation Studies as Topic; Female; Follow-Up Studi | 1973 |
Problems in therapy for the hypertensive patient.
Topics: Antihypertensive Agents; Blood Pressure; Carotid Sinus; Diuretics; Electric Stimulation; Ethacrynic | 1973 |
Human serum dopamine- -hydroxylase. Relationship to hypertension and sympathetic activity.
Topics: Adrenal Gland Neoplasms; Adult; Amphetamine; Blood Flow Velocity; Blood Pressure; Dopamine beta-Hydr | 1973 |
Side effects of hypotensive agents evaluated by a self-administered questionnaire.
Topics: Antihypertensive Agents; Defecation; Diuretics; Ejaculation; Erectile Dysfunction; Female; Guanethid | 1973 |
The reversibility of side effects of guanethidine therapy.
Topics: Adult; Diarrhea; Ejaculation; Erectile Dysfunction; Fatigue; Female; Follow-Up Studies; Guanethidine | 1973 |
Hypertension and cerebrovascular disease, adverse effects of guanethidine.
Topics: Aged; Arteriosclerosis; Cerebrovascular Disorders; Female; Guanethidine; Humans; Hypertension; Hypot | 1967 |
Mechanism of exercise hypotension after sympathetic blockade.
Topics: Adult; Amidines; Blood Pressure; Blood Volume; Cardiac Output; Forearm; Guanethidine; Heart Rate; He | 1970 |
[Hydralazine syndrome].
Topics: Diuretics; Guanethidine; Humans; Hydralazine; Hypertension; Hypotension, Orthostatic; Joint Diseases | 1970 |