guanethidine has been researched along with Heart Failure in 30 studies
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We sought to evaluate the effects of various doses of guanethidine, a sympathoinhibitory drug, on ventricular function and survival in chronic heart failure (CHF) after myocardial infarction (MI) in rats." | 7.72 | Long-term treatment with low-dose, but not high-dose, guanethidine improves ventricular function and survival of rats with heart failure after myocardial infarction. ( Asanoi, H; Fujii, N; Igawa, A; Inoue, H; Kato, B; Nozawa, T, 2003) |
| "Twenty-six patients were selected for treatment with minoxidil on the basis of hypertension which could not be controlled either because of (1) drug failures and/or (2) side effects of drugs." | 7.65 | Minoxidil in severe hypertension: value when conventional drugs have failed. ( Dormois, JC; Nies, AS; Young, JL, 1975) |
| "Thirty-six adult male SD rats were randomly divided into the following four groups: sham surgery (Sham) group, guanethidine (GD) group, abdominal transverse aorta coarctation-induced heart failure + normal saline (TAC) group, and TAC + guanethidine (TAC + GD) group." | 4.31 | Bone mass loss in chronic heart failure is associated with sympathetic nerve activation. ( Fan, D; Guan, Z; Huang, J; Jia, J; Leng, H; Li, Z; Song, C; Xu, Y; Yuan, W; Zhang, C; Zhang, W; Zhu, J, 2023) |
| "We sought to evaluate the effects of various doses of guanethidine, a sympathoinhibitory drug, on ventricular function and survival in chronic heart failure (CHF) after myocardial infarction (MI) in rats." | 3.72 | Long-term treatment with low-dose, but not high-dose, guanethidine improves ventricular function and survival of rats with heart failure after myocardial infarction. ( Asanoi, H; Fujii, N; Igawa, A; Inoue, H; Kato, B; Nozawa, T, 2003) |
| "Twenty-six patients were selected for treatment with minoxidil on the basis of hypertension which could not be controlled either because of (1) drug failures and/or (2) side effects of drugs." | 3.65 | Minoxidil in severe hypertension: value when conventional drugs have failed. ( Dormois, JC; Nies, AS; Young, JL, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (93.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Guan, Z | 1 |
| Yuan, W | 1 |
| Jia, J | 1 |
| Zhang, C | 1 |
| Zhu, J | 1 |
| Huang, J | 1 |
| Zhang, W | 1 |
| Fan, D | 1 |
| Leng, H | 1 |
| Li, Z | 1 |
| Xu, Y | 1 |
| Song, C | 1 |
| Igawa, A | 1 |
| Nozawa, T | 1 |
| Fujii, N | 1 |
| Kato, B | 1 |
| Asanoi, H | 1 |
| Inoue, H | 1 |
| GAFFNEY, TE | 2 |
| BRAUNWALD, E | 3 |
| CHIDSEY, CA | 1 |
| HARRISON, DC | 1 |
| KAHLER, RL | 1 |
| MASON, DT | 2 |
| BARTTER, FC | 2 |
| BLAGG, CR | 1 |
| GLANVILLE, JN | 1 |
| GILL, JR | 1 |
| ROY, SB | 1 |
| MATHUR, VS | 1 |
| BHATIA, ML | 1 |
| Leishman, AW | 1 |
| Sandler, G | 1 |
| Bing, OH | 1 |
| Sen, S | 1 |
| Conrad, CH | 1 |
| Brooks, WW | 1 |
| Fiorentini, C | 3 |
| Olivari, MT | 1 |
| Polese, A | 3 |
| Magrini, F | 3 |
| Moruzzi, P | 1 |
| Guazzi, M | 3 |
| Dormois, JC | 1 |
| Young, JL | 1 |
| Nies, AS | 1 |
| Carlier, J | 1 |
| Hamilton, M | 1 |
| Seedat, YK | 1 |
| Pillay, VK | 1 |
| Bock, KD | 2 |
| Freis, ED | 1 |
| Dalen, JE | 1 |
| Alpert, JS | 1 |
| Cohn, LH | 1 |
| Black, H | 1 |
| Collins, JJ | 1 |
| Koch-Weser, J | 1 |
| Muiesan, G | 1 |
| Motolese, M | 1 |
| Petz, E | 1 |
| Todisco, T | 1 |
| Bartorelli, C | 1 |
| Attar, S | 1 |
| Fardin, R | 1 |
| Ayella, R | 1 |
| McLaughlin, JS | 1 |
| Finnerty, FA | 1 |
| Yasui, H | 1 |
| Vidt, DG | 1 |
| Conn, HL | 1 |
| Detweiler, DK | 1 |
| McGiff, J | 1 |
| Luchi, RJ | 1 |
3 reviews available for guanethidine and Heart Failure
| Article | Year |
|---|---|
STUDIES ON THE FUNCTION OF THE ADRENERGIC NERVE ENDINGS IN THE HEART.
Topics: Adrenergic Agents; Biochemical Phenomena; Biochemistry; Guanethidine; Heart; Heart Failure; Heart Fu | 1963 |
Effectiveness of drug therapy in hypertension: present status. A review.
Topics: Antihypertensive Agents; Cerebrovascular Disorders; Coronary Disease; Eye Diseases; Ganglionic Block | 1971 |
Correlation of pathophysiology and pharmacotherapy in primary hypertension.
Topics: Blood Pressure; Cardiac Output; Cardiac Volume; Diuretics; Furosemide; Guanethidine; Heart Failure; | 1973 |
2 trials available for guanethidine and Heart Failure
| Article | Year |
|---|---|
Further experiences with guanethidine--a clinical assessment of 103 patients.
Topics: Adult; Aged; Blood Pressure Determination; Cardiomegaly; Cerebrovascular Disorders; Clinical Trials | 1966 |
The combination of guanethidine and hydrochlorothiazide in the treatment of arterial hypertension with and without renal failure.
Topics: Adult; Analysis of Variance; Blood Pressure; Clinical Trials as Topic; Creatine; Drug Synergism; Fem | 1968 |
25 other studies available for guanethidine and Heart Failure
| Article | Year |
|---|---|
Bone mass loss in chronic heart failure is associated with sympathetic nerve activation.
Topics: Animals; Guanethidine; Heart Failure; Male; Osteoporosis; Osteoprotegerin; RANK Ligand; Rats; Rats, | 2023 |
Long-term treatment with low-dose, but not high-dose, guanethidine improves ventricular function and survival of rats with heart failure after myocardial infarction.
Topics: Animals; Catecholamines; Dose-Response Relationship, Drug; Guanethidine; Heart Failure; Male; Myocar | 2003 |
Importance of the adrenergic nervous system in the support of circulatory function in patients with congestive heart failure.
Topics: Adrenergic Agents; Guanethidine; Heart Failure; Humans; Norepinephrine; Sympathetic Nervous System | 1963 |
STUDIES ON DIGITALIS. X. EFFECTS OF OUABAIN ON FOREARM VASCULAR RESISTANCE AND VENOUS TONE IN NORMAL SUBJECTS AND IN PATIENTS IN HEART FAILURE.
Topics: Blood Flow Velocity; Digitalis; Forearm; Guanethidine; Heart Failure; Humans; Ouabain; Pharmacology; | 1964 |
CARDIAC FAILURE AND HORMONAL CONTROL OF FLUID AND ELECTROLYTE BALANCE.
Topics: Aldosterone; Angiotensins; Catecholamines; Corticosterone; Cortisone; Edema; Guanethidine; Heart Fai | 1964 |
BILATERAL RENAL ARTERY STENOSIS WITH ALDOSTERONISM.
Topics: Angiography; Chlorides; Electrocardiography; Guanethidine; Heart Failure; Humans; Hyperaldosteronism | 1964 |
"IDIOPATHIC" EDEMA RESULTING FROM OCCULT CARDIOMYOPATHY.
Topics: Cardiac Catheterization; Cardiomyopathies; Desoxycorticosterone; Diagnosis; Digoxin; Drug Therapy; E | 1965 |
Circulatory effects of guanethidine in hypertensive heart failure.
Topics: Antihypertensive Agents; Guanethidine; Heart Failure; Humans; Hypertension | 1961 |
Guanethidine and hypertension after five years.
Topics: Albuminuria; Angina Pectoris; Blood Pressure; Cerebrovascular Disorders; Female; Follow-Up Studies; | 1967 |
Myocardial function structure and collagen in the spontaneously hypertensive rat: progression from compensated hypertrophy to haemodynamic impairment.
Topics: Animals; Body Weight; Cardiomegaly; Collagen; Guanethidine; Heart Failure; Hydralazine; Hypertension | 1984 |
[Functional response of the hypertensive decompensated heart to the removal of adrenergic effects].
Topics: Adult; Aged; Guanethidine; Heart Failure; Humans; Hypertension; Male; Middle Aged; Propranolol; Rese | 1976 |
Minoxidil in severe hypertension: value when conventional drugs have failed.
Topics: Adult; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Edema; Female; | 1975 |
[Treatment of cardiac complications in hyperthyroidism].
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Digitalis Glycosides; Guanethidine; Heart Disease | 1973 |
Hypertension.
Topics: Adrenergic beta-Antagonists; Aortic Diseases; Benzothiadiazines; Brain Diseases; Cerebrovascular Dis | 1974 |
[Conservative treatment of hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aniline Compounds; Dihydroxyphenylalanine; Female; Guaneth | 1970 |
Dissection of the thoracic aorta. Medical or surgical therapy?
Topics: Adult; Aged; Aorta, Thoracic; Aortic Aneurysm; Aortic Valve Insufficiency; Autonomic Agents; Blood P | 1974 |
Importance of the adrenergic nervous system in the support of cardiac function in patients with primary arterial hypertension.
Topics: Body Weight; Cardiac Output; Chlorthalidone; Digitalis Glycosides; Glomerular Filtration Rate; Guane | 1973 |
Role of the sympathetic nervous system in supporting cardiac function in essential arterial hypertension.
Topics: Adult; Aged; Blood Pressure; Digitalis; Diuretics; Guanethidine; Heart; Heart Failure; Heart Rate; H | 1973 |
[What is reliable in the therapy of hypertension?].
Topics: Arteriosclerosis; Cerebral Hemorrhage; Diet, Reducing; Diet, Sodium-Restricted; Guanethidine; Health | 1970 |
[Cardiac insufficiency appearing in essential arterial hypertension].
Topics: Chlorthalidone; Guanethidine; Heart Failure; Humans; Hypertension; Reserpine | 1972 |
Medical vs surgical treatment of acute dissecting aneurysms.
Topics: Acute Disease; Acute Kidney Injury; Adult; Aged; Aortic Aneurysm; Aortic Rupture; Aortography; Blood | 1971 |
Failure of repeated diazoxide injections to modify the course of severe hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Chlorthalidone; Diazoxide; Diuretics; Guanethidine; Heart F | 1971 |
The role of catecholamines in circulatory regulation on the chronic congestive heart failure. Clinical study of the urinary catecholamine excretion in the patients with chronic congestive heart failure.
Topics: Adolescent; Adult; Aged; Blood Pressure; Cardiomyopathies; Catecholamines; Coronary Disease; Digital | 1968 |
An approach to the medical treatment of hypertension in the aged.
Topics: Age Factors; Aged; Antihypertensive Agents; Cerebrovascular Disorders; Coronary Disease; Diuretics; | 1969 |
Why we have gone to the dogs.
Topics: Aldosterone; Animals; Cardiac Output; Dog Diseases; Dogs; Exercise Test; Guanethidine; Heart; Heart | 1966 |