guanethidine has been researched along with Graves Disease in 19 studies
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
Graves Disease: A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Assessment was made of 5% local guanethidine in treating eye manifestations in euthyroid patients with either treated thyrotoxicosis or ophthalmic Graves's disease." | 5.03 | Critical study of 5 per cent guanethidine in ocular manifestations of Graves's disease. ( Anderson, J; Cartlidge, NE; Crombie, AL; Hall, R, 1969) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (94.74) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LEAK, D | 1 |
| DEGROOT, LJ | 1 |
| Neves, LC | 1 |
| Cruz, AA | 1 |
| Hodes, BL | 1 |
| Frazee, L | 1 |
| Szmyd, S | 1 |
| Bricaire, H | 1 |
| Joly, J | 1 |
| Laroche, C | 1 |
| Grégoire, J | 1 |
| Turpin, G | 1 |
| Warnet, A | 1 |
| Guerre, J | 1 |
| Portos, JL | 1 |
| Christoforov, B | 1 |
| Péquignot, H | 1 |
| Ivy, HK | 1 |
| Haddad, HM | 1 |
| Bowden, AN | 1 |
| Rose, FC | 1 |
| Cartlidge, NE | 1 |
| Crombie, AL | 1 |
| Anderson, J | 1 |
| Hall, R | 1 |
| Chwirot, R | 1 |
| Gliński, J | 1 |
| Berkman, N | 1 |
| Joseph, E | 1 |
| Storch, J | 1 |
| Kjer, P | 1 |
| Cant, JS | 2 |
| Lewis, DR | 2 |
| Harrison, MT | 1 |
| Gay, AJ | 1 |
| Wolkstein, MA | 1 |
2 trials available for guanethidine and Graves Disease
| Article | Year |
|---|---|
Dysthyroid eye disease. A trial of guanethidine eye drops.
Topics: Clinical Trials as Topic; Eye Manifestations; Eyelids; Female; Graves Disease; Guanethidine; Humans; | 1969 |
Critical study of 5 per cent guanethidine in ocular manifestations of Graves's disease.
Topics: Clinical Trials as Topic; Eye Manifestations; Eyelid Diseases; Female; Graves Disease; Guanethidine; | 1969 |
17 other studies available for guanethidine and Graves Disease
| Article | Year |
|---|---|
Adrenergic blockade and thyrotoxicosis.
Topics: Adrenergic Agents; Exophthalmos; Goiter; Graves Disease; Guanethidine; Humans; Thiouracil; Thyrotoxi | 1963 |
THERAPY OF THYROTOXICOSIS.
Topics: Adolescent; Antithyroid Agents; Child; Female; Goiter; Graves Disease; Guanethidine; Heart Diseases; | 1964 |
Effect of darkness on upper eyelid position.
Topics: Adolescent; Adult; Age Distribution; Aged; Child; Child, Preschool; Darkness; Eyelids; Female; Grave | 2005 |
Thyroid orbitopathy: an update.
Topics: Adult; Aged; Diplopia; Eyelids; Female; Graves Disease; Guanethidine; Humans; Oculomotor Muscles; Or | 1979 |
Editorial: The eye signs of Graves disease.
Topics: Edema; Exophthalmos; Eye; Eye Manifestations; Female; Graves Disease; Guanethidine; Humans; Male; Mu | 1974 |
[Some recent progress in the medical treatment of hyperthyroidism].
Topics: Adult; Antithyroid Agents; Female; Graves Disease; Guanethidine; Humans; Hydroxypropiophenone; Hyper | 1967 |
[Therapy of acute thyrotoxic attacks].
Topics: Adrenal Glands; Antithyroid Agents; Catecholamines; Cortisone; Drug Synergism; Graves Disease; Guane | 1968 |
[Hyperthyroidism in general medicine].
Topics: Adult; Aged; Carbimazole; Diarrhea; Electrocardiography; Emaciation; Female; Fever; France; Graves D | 1971 |
Medical approach to ophthalmopathy of Graves' disease.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Diagnosis, Differ | 1972 |
Pathogenesis and treatment of endocrine exophthalmos.
Topics: Blepharoptosis; Dexamethasone; Diplopia; Edema; Exophthalmos; Eye Neoplasms; Glaucoma; Graves Diseas | 1973 |
[Effectiveness of guanethidine in preventing the retraction of the upper lid in Graves' disease].
Topics: Adult; Eyelid Diseases; Female; Graves Disease; Guanethidine; Humans | 1972 |
[Ocular manifestations of Basedow's disease and local administration of guanethidine].
Topics: Eye Manifestations; Female; Graves Disease; Guanethidine; Humans; Male; Ophthalmic Solutions | 1971 |
[Action of 5 per cent guanethidine sulfate (ismeline) eye drops on lid retraction during Basedow's disease].
Topics: Adult; Eye Manifestations; Eyelid Diseases; Eyelids; Female; Graves Disease; Guanethidine; Humans; M | 1971 |
[Retraction of the eyelids of endocrine origin treated with guanethidine (Ismelin) eyedrops].
Topics: Adult; Eyelids; Female; Graves Disease; Guanethidine; Humans; Middle Aged; Ophthalmic Solutions | 1968 |
Treatment of dysthyroid ophthalmopathy with local guanethidine.
Topics: Eye Manifestations; Eyelids; Female; Graves Disease; Guanethidine; Humans; Hyperthyroidism; Male; Mi | 1969 |
Unwanted pharmacological effects of local guanethidine in the treatment of dysthyroid upper lid retraction.
Topics: Drug Hypersensitivity; Eye Manifestations; Eyelids; Female; Graves Disease; Guanethidine; Humans; Ke | 1969 |
Topical guanethidine therapy for endocrine lid retraction.
Topics: Eye Diseases; Eyelids; Graves Disease; Guanethidine; Humans | 1966 |