guanethidine has been researched along with Disease Models, Animal in 40 studies
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Sympathectomy using guanethidine significantly alleviated mechanical allodynia 6 weeks after cuff, when peak sympathetic sprouting was observed, having no effect at 2 weeks, when fibres were absent." | 3.81 | Sympathetic fibre sprouting in the skin contributes to pain-related behaviour in spared nerve injury and cuff models of neuropathic pain. ( Magnussen, C; Nascimento, FP; Ribeiro-da-Silva, A; Yousefpour, N, 2015) |
| " Chemical sympathectomy induced by guanethidine (100 mg/kg body weight, for 1 or 2 days) reduced muscle norepinephrine content to negligible levels (less than 5%), decreased plasma epinephrine concentration, and further increased the high rate of protein degradation in muscles from acutely diabetic rats." | 3.74 | Chemical sympathectomy further increases muscle protein degradation of acutely diabetic rats. ( Baviera, AM; Kettelhut, IC; Migliorini, RH; Navegantes, LC; Zanon, NM, 2008) |
| "Chronic hypertension has been produced in mongrel dogs by the long-term oral administration of metyrapone (100 mg/kg per day)." | 3.65 | Multifactorial analysis of chronic hypertension induced by electrolyte-active steroids in trained, unanesthetized dogs. ( Bravo, EL; Dustan, HP; Tarazi, RC, 1977) |
| "Submaxillary saliva from reserpine-treated rats was found to have alterations in composition similar to those reported in the same secretion from patients with cystic fibrosis." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva. ( Adshead, PC; Barbero, GJ; Martinez, JR; Quissell, DO, 1975) |
| " The final study determined the dose-response relationship for paclitaxel." | 1.40 | Chemical renal denervation in the rat. ( Consigny, PM; Davalian, D; Donn, R; Hu, J; Rieser, M; Stolarik, D, 2014) |
| "Although chronic pain is the most common symptom of arthritis, relatively little is known about the mechanisms driving it." | 1.39 | Sympathetic fiber sprouting in inflamed joints and adjacent skin contributes to pain-related behavior in arthritis. ( Longo, G; Osikowicz, M; Ribeiro-da-Silva, A, 2013) |
| "Modulation of ultraviolet-induced hyperalgesia and cytokine upregulation by interleukins 10 and 13." | 1.35 | Ultra violet-induced localized inflammatory hyperalgesia in awake rats and the role of sensory and sympathetic innervation of the skin. ( Farhat, O; Jabbur, SJ; Le Bars, D; Rahal, O; Saadé, NE; Safieh-Garabedian, B, 2008) |
| "Clinical and experimental studies of neuropathic pain support the hypothesis that a functional coupling between postganglionic sympathetic efferent and sensory afferent fibers contributes to the pain." | 1.34 | Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain. ( Allchorne, AJ; Beggah, AT; Decosterd, I; Pertin, M; Woolf, CJ, 2007) |
| "Guanethidine treatment caused significant reductions in systolic arterial blood pressure and indices of left ventricular contractility and relaxation (p less than 0." | 1.28 | Effect of chemical sympathectomy on cardiac hypertrophy and hemodynamics following myocardial infarction in the rat. ( Fishbein, MC; Rubin, SA, 1990) |
| " After two weeks of daily guanethidine dosing (50 mg/kg/day, i." | 1.27 | Development of tolerance to guanethidine in three hypertensive rat models. ( Rankin, GO; Sawutz, DG; Watkins, BE, 1984) |
| "Postural hypotension is a common side effect observed in the treatment of hypertension with various drugs." | 1.27 | Evaluation of the risk for drug-induced postural hypotension in an experimental model: investigations with carvedilol, prazosin, labetalol, and guanethidine. ( Bartsch, W; Böhm, E; Hooper, RG; Sponer, G; Strein, K, 1987) |
| "The guanethidine-treated animals gained less weight, had ptosis, and had a lower mean arterial blood pressure in the supine and upright tilted positions." | 1.27 | Guanethidine adrenergic neuropathy: an animal model of selective autonomic neuropathy. ( Low, PA; Ward, KK; Zochodne, DW, 1988) |
| " The dose-response relation of the coronary diameter to histamine was not influenced by pretreatment with the nerve transmitter blockers guanethidine (3 X 10(-6) M), atropine (10(-6) M), and tetrodotoxin (3 X 10(-7) M)." | 1.27 | Pathogenesis of coronary artery spasm in miniature swine with regional intimal thickening after balloon denudation. ( Egashira, K; Kawasaki, T; Kobayashi, T; Nakamura, M; Tomoike, H; Yamamoto, Y, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (55.00) | 18.7374 |
| 1990's | 3 (7.50) | 18.2507 |
| 2000's | 7 (17.50) | 29.6817 |
| 2010's | 8 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Longo, G | 1 |
| Osikowicz, M | 1 |
| Ribeiro-da-Silva, A | 2 |
| Consigny, PM | 1 |
| Davalian, D | 1 |
| Donn, R | 1 |
| Hu, J | 1 |
| Rieser, M | 1 |
| Stolarik, D | 1 |
| Hachani, R | 1 |
| Dab, H | 1 |
| Feriani, A | 1 |
| Saber, S | 1 |
| Sakly, M | 1 |
| Vicaut, E | 1 |
| Callebert, J | 1 |
| Sercombe, R | 1 |
| Kacem, K | 1 |
| McKim, DB | 1 |
| Patterson, JM | 1 |
| Wohleb, ES | 1 |
| Jarrett, BL | 1 |
| Reader, BF | 1 |
| Godbout, JP | 1 |
| Sheridan, JF | 1 |
| Nascimento, FP | 1 |
| Magnussen, C | 1 |
| Yousefpour, N | 1 |
| Chen, J | 1 |
| Song, GQ | 1 |
| Yin, J | 1 |
| Koothan, T | 1 |
| Chen, JD | 1 |
| Baviera, AM | 1 |
| Zanon, NM | 1 |
| Navegantes, LC | 1 |
| Migliorini, RH | 1 |
| Kettelhut, IC | 1 |
| Augustyniak, RA | 1 |
| Picken, MM | 1 |
| Leonard, D | 1 |
| Zhou, XJ | 1 |
| Zhang, W | 1 |
| Victor, RG | 1 |
| Chen, HS | 1 |
| Qu, F | 1 |
| He, X | 1 |
| Wang, Y | 1 |
| Wen, WW | 1 |
| Fujiwara, H | 1 |
| Hashikawa-Hobara, N | 1 |
| Wake, Y | 1 |
| Takatori, S | 1 |
| Goda, M | 1 |
| Higuchi, H | 1 |
| Zamami, Y | 1 |
| Tangsucharit, P | 1 |
| Kawasaki, H | 1 |
| De Salvatore, G | 1 |
| De Salvia, MA | 1 |
| Piepoli, AL | 1 |
| Natale, L | 1 |
| Porro, C | 1 |
| Nacci, C | 1 |
| Mitolo, CI | 1 |
| Mitolo-Chieppa, D | 1 |
| Lomax, AE | 1 |
| O'Reilly, M | 1 |
| Neshat, S | 1 |
| Vanner, SJ | 1 |
| Pertin, M | 1 |
| Allchorne, AJ | 1 |
| Beggah, AT | 1 |
| Woolf, CJ | 1 |
| Decosterd, I | 1 |
| Saadé, NE | 1 |
| Farhat, O | 1 |
| Rahal, O | 1 |
| Safieh-Garabedian, B | 1 |
| Le Bars, D | 1 |
| Jabbur, SJ | 1 |
| Rankin, GO | 1 |
| Watkins, BE | 1 |
| Sawutz, DG | 1 |
| Green, MA | 1 |
| Egle, JL | 1 |
| Lee, CH | 1 |
| Strosberg, AM | 1 |
| Roszkowski, AP | 1 |
| Warren, LA | 1 |
| Ruwart, MJ | 1 |
| Klepper, MS | 1 |
| Rush, BD | 1 |
| Kim, SH | 1 |
| Na, HS | 1 |
| Kwangsup, S | 1 |
| Jin, MC | 1 |
| Adding, LC | 1 |
| Agvald, P | 1 |
| Persson, MG | 1 |
| Gustafsson, LE | 1 |
| Richards, CA | 1 |
| Carr, D | 1 |
| Spitz, L | 1 |
| Milla, PJ | 1 |
| Andrews, PL | 1 |
| Vidal, RF | 1 |
| Dikstein, S | 1 |
| Pasik, T | 1 |
| Pasik, P | 1 |
| Wall, PD | 1 |
| Scadding, JW | 1 |
| Tomkiewicz, MM | 1 |
| Bravo, EL | 1 |
| Tarazi, RC | 1 |
| Dustan, HP | 1 |
| Bhargava, KP | 1 |
| Srivastava, VK | 1 |
| Barthwal, JP | 1 |
| Sinha, JN | 1 |
| Martinez, JR | 1 |
| Adshead, PC | 1 |
| Quissell, DO | 1 |
| Barbero, GJ | 1 |
| Perhach, JL | 1 |
| Ferguson, HC | 1 |
| McKinney, GR | 1 |
| Rubin, SA | 1 |
| Fishbein, MC | 1 |
| Bartsch, W | 1 |
| Sponer, G | 1 |
| Strein, K | 1 |
| Böhm, E | 1 |
| Hooper, RG | 1 |
| Zochodne, DW | 1 |
| Ward, KK | 1 |
| Low, PA | 1 |
| Krecek, J | 1 |
| Dolezel, S | 1 |
| Dlouhá, H | 1 |
| Zicha, J | 1 |
| Coderre, TJ | 1 |
| Grimes, RW | 1 |
| Melzack, R | 1 |
| Yamamoto, Y | 1 |
| Tomoike, H | 1 |
| Egashira, K | 1 |
| Kobayashi, T | 1 |
| Kawasaki, T | 1 |
| Nakamura, M | 1 |
| Martin, L | 1 |
| Anton, AH | 1 |
| Poyser, RH | 1 |
| Shorter, JH | 1 |
| Whiting, RL | 1 |
| Osterholm, JL | 1 |
| Mathews, GJ | 1 |
| Irvin, JD | 1 |
| Calesnick, B | 1 |
| Overbeck, HW | 1 |
| Komarek, A | 1 |
| Dietrich, FM | 1 |
| Baum, T | 1 |
| Eckfeld, DK | 1 |
| Metz, N | 1 |
| Dinish, JL | 1 |
| Rowles, G | 1 |
| Van Pelt, R | 1 |
| Shropshire, AT | 1 |
| Fernandez, SP | 1 |
| Gluckman, MI | 1 |
| Bruce, WF | 1 |
1 review available for guanethidine and Disease Models, Animal
| Article | Year |
|---|---|
Deafferentation and chronic pain in animals: an evaluation of evidence suggesting autotomy is related to pain.
Topics: Afferent Pathways; Animals; Behavior, Animal; Capsaicin; Chronic Disease; Denervation; Disease Model | 1986 |
39 other studies available for guanethidine and Disease Models, Animal
| Article | Year |
|---|---|
Sympathetic fiber sprouting in inflamed joints and adjacent skin contributes to pain-related behavior in arthritis.
Topics: Adrenergic Fibers; Analysis of Variance; Animals; Ankle Joint; Arthritis; Calcitonin Gene-Related Pe | 2013 |
Chemical renal denervation in the rat.
Topics: Animals; Chromatography, Liquid; Denervation; Disease Models, Animal; Dose-Response Relationship, Dr | 2014 |
Hypercholesterolemic diet induces vascular smooth muscle cell apoptosis in sympathectomized rats via intrinsic pathway.
Topics: Actins; Animals; Animals, Newborn; Aorta, Abdominal; Apoptosis; Diet; Disease Models, Animal; DNA Fr | 2014 |
Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat.
Topics: Animals; Anxiety; Brain; Cell Movement; Cohort Studies; Disease Models, Animal; Dominance-Subordinat | 2016 |
Sympathetic fibre sprouting in the skin contributes to pain-related behaviour in spared nerve injury and cuff models of neuropathic pain.
Topics: Adrenergic Fibers; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Cold Temperature; Der | 2015 |
Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs.
Topics: Adrenergic Agents; Animals; Catheterization; Disease Models, Animal; Dogs; Electroacupuncture; Femal | 2008 |
Chemical sympathectomy further increases muscle protein degradation of acutely diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Calcium; Diabetes Mellitus, Experimental; Disease Models, Anima | 2008 |
Sympathetic nerves and the progression of chronic kidney disease during 5/6 nephrectomy: studies in sympathectomized rats.
Topics: Animals; Animals, Newborn; Blood Pressure; Chronic Disease; Disease Models, Animal; Disease Progress | 2010 |
Chemical or surgical sympathectomy prevents mechanical hyperalgesia induced by intraplantar injection of bee venom in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals | 2010 |
Neurogenic vascular responses in male mouse mesenteric vascular beds.
Topics: Acetylcholine; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Guanethi | 2012 |
Effects of in vivo treatment with interleukins 1beta and 6 on rat mesenteric vascular bed reactivity.
Topics: Acetylcholine; Animals; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Syn | 2003 |
Sympathetic vasoconstrictor regulation of mouse colonic submucosal arterioles is altered in experimental colitis.
Topics: Adenosine Triphosphate; Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; | 2007 |
Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Ganglia, Spinal; Guanethidine; Immunohistochemist | 2007 |
Ultra violet-induced localized inflammatory hyperalgesia in awake rats and the role of sensory and sympathetic innervation of the skin.
Topics: Animals; Cytokines; Dermatitis; Disease Models, Animal; Guanethidine; Hyperalgesia; Nerve Growth Fac | 2008 |
Development of tolerance to guanethidine in three hypertensive rat models.
Topics: Animals; Blood Pressure; Disease Models, Animal; Drug Tolerance; Female; Guanethidine; Heart Rate; H | 1984 |
The effects of acetaldehyde and acrolein on blood pressure in guanethidine-pretreated hypertensive rats.
Topics: Acetaldehyde; Acrolein; Aldehydes; Animals; Blood Pressure; Disease Models, Animal; Drug Interaction | 1983 |
A model for evaluation of postural hypotension induced by drugs in conscious restrained normotensive rats.
Topics: Anesthetics; Animals; Antihypertensive Agents; Consciousness; Disease Models, Animal; Guanethidine; | 1982 |
Adrenergic and cholinergic contributions to decreased gastric emptying, small intestinal transit, and colonic transit in the postoperative ileus rat.
Topics: Animals; Bethanechol Compounds; Colon; Disease Models, Animal; Gastric Emptying; Gastrointestinal Mo | 1980 |
Effects of sympathectomy on a rat model of peripheral neuropathy.
Topics: Animals; Disease Models, Animal; Guanethidine; Hot Temperature; Male; Pain; Pain Measurement; Periph | 1993 |
Regulation of pulmonary nitric oxide by carbon dioxide is intrinsic to the lung.
Topics: Animals; Brain; Brain Ischemia; Breath Tests; Carbon Dioxide; Carotid Arteries; Disease Models, Anim | 1999 |
Nissen-type fundoplication and its effects on the emetic reflex and gastric motility in the ferret.
Topics: Animals; Antidiarrheals; Atropine; Behavior, Animal; Disease Models, Animal; Electric Stimulation; F | 2000 |
[Rabbit experimental glaucoma--preliminary study (author's transl)].
Topics: Aminocaproates; Aminocaproic Acid; Animals; Disease Models, Animal; Disseminated Intravascular Coagu | 1978 |
Experimental models of oculomotor dysfunction in the rhesus monkey.
Topics: Adrenergic alpha-Antagonists; Animals; Corpus Callosum; Disease Models, Animal; Eye Diseases; Eye Mo | 1975 |
The production and prevention of experimental anesthesia dolorosa.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Female; Guanethidine; Leg; Male; Mice; Mice, Inbr | 1979 |
Multifactorial analysis of chronic hypertension induced by electrolyte-active steroids in trained, unanesthetized dogs.
Topics: Acebutolol; Aldosterone; Animals; Chronic Disease; Clonidine; Corticosterone; Diet, Sodium-Restricte | 1977 |
Significance of spinal autonomic loci in post coronary ligation arrhythmia.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Catecholamines; Chloralose; Chlorisondamine | 1976 |
The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva.
Topics: Animals; Biological Assay; Bivalvia; Calcium; Carbohydrates; Cilia; Cystic Fibrosis; Disease Models, | 1975 |
Evaluation of antihypertensive agents in the stress-induced hypertensive rat.
Topics: Animals; Antihypertensive Agents; Chlorisondamine; Disease Models, Animal; Drug Evaluation, Preclini | 1975 |
Effect of chemical sympathectomy on cardiac hypertrophy and hemodynamics following myocardial infarction in the rat.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Female; Guaneth | 1990 |
Evaluation of the risk for drug-induced postural hypotension in an experimental model: investigations with carvedilol, prazosin, labetalol, and guanethidine.
Topics: Animals; Blood Pressure; Carbazoles; Carvedilol; Disease Models, Animal; Guanethidine; Hypotension, | 1987 |
Guanethidine adrenergic neuropathy: an animal model of selective autonomic neuropathy.
Topics: Animals; Autonomic Nervous System Diseases; Blood Pressure; Disease Models, Animal; Electric Stimula | 1988 |
Sympathetic nervous system and age-dependent salt hypertension in Brattleboro rats.
Topics: Aging; Animals; Disease Models, Animal; Female; Guanethidine; Hypertension; Male; Nephrectomy; Rats; | 1987 |
Pathogenesis of coronary artery spasm in miniature swine with regional intimal thickening after balloon denudation.
Topics: Animals; Atropine; Calcium; Coronary Vasospasm; Coronary Vessels; Disease Models, Animal; Endotheliu | 1987 |
Toxicity of acids and bases after intraperitoneal injection.
Topics: Acetates; Acids; Alkalies; Analgesics; Anesthetics, Local; Animals; Anti-Bacterial Agents; Body Temp | 1970 |
Proceedings: The production of hypertension and the effects of some antihypertensive agents in the conscious unrestrained cat.
Topics: Animals; Antihypertensive Agents; Cats; Cellophane; Clonidine; Corticosterone; Delayed-Action Prepar | 1974 |
Chapter 29. Anti-norepinephrine therapy against traumatic hemorrhagic necrosis of the spinal cord: preliminary report.
Topics: Animals; Bretylium Compounds; Cats; Dihydroxyphenylalanine; Disease Models, Animal; Disulfiram; Guan | 1973 |
Hemodynamics of early experimental renal hypertension in dogs. Normal limb blood flow, elevated limb vascular resistance, and decreased venous compliance.
Topics: Animals; Blood Pressure; Blood Volume; Diazoxide; Disease Models, Animal; Dogs; Femoral Vein; Foreli | 1972 |
Chemical prevention of experimental allergic encephalomyelitis in rats: a quantitative evaluation of steroids and various non-steroid drugs.
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Bis-Trimethylammonium Compounds; Cortisone; Cyclopho | 1971 |
2,6-Dichlorobenzylidene amino guanidine acetate (Wy-8678). A new hypotensive agent.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Female; Guanethidine; Guan | 1969 |