guanethidine has been researched along with Cystic Fibrosis in 3 studies
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Submaxillary saliva from reserpine-treated rats was found to have alterations in composition similar to those reported in the same secretion from patients with cystic fibrosis." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva. ( Adshead, PC; Barbero, GJ; Martinez, JR; Quissell, DO, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chernick, WS | 2 |
| Barbero, GJ | 2 |
| Martinez, JR | 1 |
| Adshead, PC | 1 |
| Quissell, DO | 1 |
3 other studies available for guanethidine and Cystic Fibrosis
| Article | Year |
|---|---|
Reversal of submaxillary salivary alterations in cystic fibrosis by guanethidine.
Topics: Amylases; Bretylium Compounds; Calcium; Cystic Fibrosis; Guanethidine; Humans; Neuraminic Acids; Nit | 1967 |
The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva.
Topics: Animals; Biological Assay; Bivalvia; Calcium; Carbohydrates; Cilia; Cystic Fibrosis; Disease Models, | 1975 |
Pharmacological aspects of submaxillary gland secretion in cystic fibrosis.
Topics: Adult; Autonomic Nervous System; Bretylium Compounds; Calcium; Child; Cystic Fibrosis; Fucose; Guane | 1968 |