guanethidine has been researched along with Cardiomegaly in 11 studies
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Symptoms due to orthostatic and exertional hypotension occurred in 23-4 per cent of 448 hypertensive patients treated with guanethidine, debrisoquine, or bethanidine." | 3.65 | Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure. ( Smith, AJ; Talbot, S, 1975) |
| "Guanethidine treatment caused significant reductions in systolic arterial blood pressure and indices of left ventricular contractility and relaxation (p less than 0." | 1.28 | Effect of chemical sympathectomy on cardiac hypertrophy and hemodynamics following myocardial infarction in the rat. ( Fishbein, MC; Rubin, SA, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (90.91) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| FLEMING, PR | 1 |
| CHAMBERLAIN, DA | 1 |
| HOWARD, J | 1 |
| Bing, OH | 1 |
| Sen, S | 1 |
| Conrad, CH | 1 |
| Brooks, WW | 1 |
| Bobik, A | 1 |
| Korner, P | 1 |
| Ostman-Smith, I | 1 |
| Talbot, S | 1 |
| Smith, AJ | 1 |
| Kuo, JF | 1 |
| Davis, CW | 1 |
| Tse, J | 1 |
| Rubin, SA | 1 |
| Fishbein, MC | 1 |
| Seedat, YK | 1 |
| Pillay, VK | 1 |
| Weiss, L | 1 |
| Kilcoyne, MM | 1 |
| Thomson, GE | 1 |
| Branche, G | 1 |
| Williams, M | 1 |
| Garnier, C | 1 |
| Chiles, B | 1 |
| Soland, T | 1 |
1 review available for guanethidine and Cardiomegaly
| Article | Year |
|---|---|
Cardiac sympathetic nerves as the final common pathway in the induction of adaptive cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Guanethidine; Heart; Humans; Hypertension; Norepinephrine; Physical Exertion; | 1981 |
1 trial available for guanethidine and Cardiomegaly
| Article | Year |
|---|---|
Further experiences with guanethidine--a clinical assessment of 103 patients.
Topics: Adult; Aged; Blood Pressure Determination; Cardiomegaly; Cerebrovascular Disorders; Clinical Trials | 1966 |
9 other studies available for guanethidine and Cardiomegaly
| Article | Year |
|---|---|
HYPERTENSIVE HEART DISEASE.
Topics: Angina Pectoris; Cardiomegaly; Coronary Disease; Drug Therapy; Dyspnea; Dyspnea, Paroxysmal; Electro | 1964 |
GUANETHIDINE AND METHYLDOPA: A HAEMODYNAMIC STUDY.
Topics: Blood Circulation; Blood Pressure Determination; Cardiomegaly; Drug Therapy; Dye Dilution Technique; | 1964 |
Myocardial function structure and collagen in the spontaneously hypertensive rat: progression from compensated hypertrophy to haemodynamic impairment.
Topics: Animals; Body Weight; Cardiomegaly; Collagen; Guanethidine; Heart Failure; Hydralazine; Hypertension | 1984 |
Cardiac beta adrenoceptors and adenylate cyclase in normotensive and renal hypertensive rabbits during changes in autonomic activity.
Topics: Adenosine Triphosphatases; Adenylyl Cyclases; Animals; Autonomic Nervous System; Blood Pressure; Car | 1981 |
Factors predisposing to postural hypotensive symptoms in the treatment of high blood pressure.
Topics: Bethanidine; Cardiomegaly; Circadian Rhythm; Debrisoquin; Female; Guanethidine; Guanidines; Heart Ra | 1975 |
Depressed cardiac cyclic GMP-dependent protein kinase in spontaneously hypertensive rats and its further depression by guanethidine.
Topics: Animals; Cardiomegaly; Chronic Disease; Cyclic GMP; Guanethidine; Hypertension; Lung; Myocardium; Pr | 1976 |
Effect of chemical sympathectomy on cardiac hypertrophy and hemodynamics following myocardial infarction in the rat.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Female; Guaneth | 1990 |
Aspects of the relation between functional and structural cardiovascular factors in primary hypertension. Experimental studies in spontaneously hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Capillary Resistance; Cardiac Output; Cardiomegaly; Coronary Circula | 1974 |
Characteristics of hypertension in the black population.
Topics: Adult; Angiotensin II; Animals; Black or African American; Cardiomegaly; Cerebrovascular Disorders; | 1974 |