guanethidine has been researched along with Aging in 34 studies
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Guanethidine treatment produced a massive sympathectomy, as synaptic vesicle development was totally arrested; the functional consequence of this treatment was confirmed by the attenuation of chronotropic responses to tyramine, a drug which acts by displacement of norepinephrine from the noradrenergic terminal." | 1.26 | Maturation of sympathetic neurotransmission in the rat heart. IV. Effects guanethidine-induced sympathectomy on neonatal development of synaptic vesicles, synaptic terminal function and heart growth. ( Bareis, DL; Lau, C; Morgan, RE; Slotkin, TA, 1981) |
| "Guanethidine sulfate was administered to rats from birth to 14 days of age." | 1.26 | Histologic evaluation of the sympathectomy induced by guanethidine sulfate in neonatal rats. ( Herskovits, MS; Singh, IJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (58.82) | 18.7374 |
| 1990's | 8 (23.53) | 18.2507 |
| 2000's | 5 (14.71) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maselli, MA | 1 |
| Trisolini, P | 1 |
| Demma, I | 1 |
| Pezzolla, F | 1 |
| De Ponti, F | 1 |
| Nigmatullina, RR | 1 |
| Khuramshin, IG | 1 |
| Nasyrova, AG | 1 |
| FREIS, ED | 1 |
| NUTTALL, FQ | 1 |
| DOE, RP | 1 |
| Nevzorova, MN | 1 |
| Tiatenkova, NN | 1 |
| Filimonov, VI | 1 |
| Chávez-Genaro, R | 1 |
| Lombide, P | 1 |
| Domínguez, R | 1 |
| Rosas, P | 1 |
| Vázquez-Cuevas, F | 1 |
| Bareis, DL | 1 |
| Morgan, RE | 1 |
| Lau, C | 1 |
| Slotkin, TA | 2 |
| Rodionov, IM | 3 |
| Yarygin, VN | 1 |
| Mukhammedov, A | 2 |
| Manukhin, BN | 2 |
| Lebedev, DB | 2 |
| Nesterova, LA | 1 |
| Herskovits, MS | 2 |
| Singh, IJ | 2 |
| Antonaccio, MJ | 1 |
| Cavaliere, T | 1 |
| Cote, D | 1 |
| Markov, VN | 2 |
| McKenzie, JC | 1 |
| Klein, RM | 1 |
| Iarygin, VN | 5 |
| Lebedev, LB | 1 |
| Milner, P | 2 |
| Lincoln, J | 2 |
| Belai, A | 1 |
| Burnstock, G | 2 |
| Zefirov, TL | 1 |
| Sviatova, NV | 1 |
| Takeuchi, T | 1 |
| Niioka, S | 1 |
| Yamaji, M | 1 |
| Okishio, Y | 1 |
| Ishii, T | 1 |
| Nishio, H | 1 |
| Takatsuji, K | 1 |
| Hata, F | 1 |
| Khalil, Z | 1 |
| Merhi, M | 1 |
| Aikawa, K | 1 |
| Yokota, T | 1 |
| Okamura , H | 1 |
| Yamaguchi, O | 1 |
| Bartolomé, J | 1 |
| Bartolomé, M | 1 |
| Seidler, J | 1 |
| Anderson, TR | 1 |
| Borisov, MM | 1 |
| Doronin, PP | 1 |
| Zueva, LV | 1 |
| Kulaev, BS | 1 |
| Nomura, Y | 1 |
| Naitoh, F | 1 |
| Segawa, T | 1 |
| Li, SJ | 1 |
| Wong, SC | 1 |
| Hong, JS | 1 |
| Ingenito, AJ | 1 |
| Eulry, F | 1 |
| Lechevalier, D | 1 |
| Pats, B | 1 |
| Alliaume, C | 1 |
| Crozes, P | 1 |
| Vasseur, P | 1 |
| Coutant, G | 1 |
| Felten, D | 1 |
| Pattin, S | 1 |
| Corr, LA | 1 |
| Aberdeen, JA | 1 |
| Kawasaki, H | 1 |
| Saito, A | 1 |
| Takasaki, K | 1 |
| Chuchkova, NN | 1 |
| Grigor'eva, AV | 2 |
| Riashchikov, SN | 1 |
| Potapov, SI | 1 |
| Krecek, J | 1 |
| Dolezel, S | 1 |
| Dlouhá, H | 1 |
| Zicha, J | 1 |
| Sitdikov, FG | 1 |
| Savin, VF | 1 |
| Simpson, LL | 1 |
34 other studies available for guanethidine and Aging
| Article | Year |
|---|---|
Gender- and age-related differences in muscular and nerve-mediated responses in human colon.
Topics: Aged; Aged, 80 and over; Aging; Atropine; Carbachol; Colon; Dose-Response Relationship, Drug; Electr | 2011 |
[Effect of sympathectomy on the heart pump function in rats during postnatal ontogenesis].
Topics: Aging; Animals; Animals, Newborn; Blood Volume; Coronary Circulation; Guanethidine; Heart; Heart Rat | 2002 |
OFFICE EVALUATION OF THE HYPERTENSIVE PATIENT. II.
Topics: Aging; Blood Pressure; Blood Pressure Determination; Central Nervous System; Diuretics; Fundus Oculi | 1963 |
THE ACHILLES REFLEX IN THYROID DISORDERS; A CRITICAL EVALUATION.
Topics: Achilles Tendon; Adrenocorticotropic Hormone; Aging; Anemia; Anemia, Pernicious; Aspirin; Cold Tempe | 1964 |
[Morphometric characteristics of microcirculatory bed of olfactory bulbs in the desympathized albino rat].
Topics: Aging; Alkaline Phosphatase; Animals; Animals, Newborn; Endothelium, Vascular; Guanethidine; Microci | 2004 |
Sympathetic pharmacological denervation in ageing rats: effects on ovulatory response and follicular population.
Topics: Aging; Animals; Estrous Cycle; Female; Gonadotropins; Guanethidine; Multivariate Analysis; Norepinep | 2007 |
Maturation of sympathetic neurotransmission in the rat heart. IV. Effects guanethidine-induced sympathectomy on neonatal development of synaptic vesicles, synaptic terminal function and heart growth.
Topics: Aging; Animals; Animals, Newborn; Female; Guanethidine; Heart; Heart Rate; Male; Muscles; Organ Size | 1981 |
Growth of sympathetic postganglionic axons after partial chemical destruction with guanethidine.
Topics: Aging; Animals; Axons; Ganglia, Sympathetic; Guanethidine; Male; Norepinephrine; Rats; Sympathectomy | 1981 |
Effect of guanethidine-induced sympathectomy on osteoblastic activity in the rat femur evaluated by 3H-proline autoradiography.
Topics: Aging; Animals; Autoradiography; Female; Femur; Guanethidine; Male; Osteoblasts; Proline; Rats; Rats | 1984 |
Ontogenesis of hypertension and responsiveness to antihypertensive agents in spontaneously hypertensive rats.
Topics: Aging; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Guanethidine; Heart Rate; Hypertensi | 1980 |
[Cytological analysis of sympathetic neurons of 1- and 5-month-old normal rats and rats subjected to partial sympathectomy].
Topics: Aging; Animals; Cell Count; Ganglia, Sympathetic; Guanethidine; Rats; Sympathectomy, Chemical | 1982 |
Effects of guanethidine-induced sympathectomy on morphology of the pre- and postclosure ileum of the neonatal rat.
Topics: Aging; Animals; Animals, Newborn; Epithelial Cells; Guanethidine; Ileum; Microscopy, Electron; Micro | 1982 |
Histologic evaluation of the sympathectomy induced by guanethidine sulfate in neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Ganglia, Sympathetic; Guanethidine; Neurons; Rats; Sy | 1982 |
[Age-related changes in the sympathetic innervation of effector organs in the rat after partial sympathectomy with guanethidine].
Topics: Adrenergic Fibers; Aging; Animals; Autonomic Fibers, Preganglionic; Cell Count; Electrophysiology; G | 1982 |
[Autoradiographic analysis of the migration of slowly translocating protein into the axons of sympathetic neurocytes of normally developing and sympathectomized mice of different ages].
Topics: Aging; Animals; Autoradiography; Axons; Guanethidine; Mice; Proteins; Sympathetic Nervous System | 1980 |
Plasticity in the myenteric plexus of the rat ileum after long-term sympathectomy.
Topics: Adrenergic Fibers; Aging; Animals; Animals, Newborn; Guanethidine; Ileum; Immunohistochemistry; Musc | 1995 |
[Age-related vagal regulation features of chronotropic heart function in sympathectomized and intact rats].
Topics: Aging; Animals; Electric Stimulation; Electrocardiography; Female; Guanethidine; Heart; Heart Rate; | 1997 |
Decrease in participation of nitric oxide in nonadrenergic, noncholinergic relaxation of rat intestine with age.
Topics: Adrenergic Agents; Aging; Animals; Arginine; Atropine; Colon; Electric Stimulation; Enzyme Inhibitor | 1998 |
[Monoamine level, M-cholino-, and beta-adrenergic reception in the cranial cervical sympathetic ganglion during ontogenesis in desympathectomized rats].
Topics: Aging; Animals; Biogenic Monoamines; Guanethidine; Histocytochemistry; Male; Rats; Receptors, Adrene | 1999 |
Effects of aging on neurogenic vasodilator responses evoked by transcutaneous electrical nerve stimulation: relevance to wound healing.
Topics: Aging; Animals; Guanethidine; Male; Peripheral Nervous System; Phentolamine; Rats; Rats, Sprague-Daw | 2000 |
Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the changes with aging.
Topics: Aging; Aminoquinolines; Animals; Arginine; Atropine; Electric Stimulation; Guanethidine; Histocytoch | 2001 |
Effects of early postnatal guanethidine administration on adrenal medulla and brain of developing rats.
Topics: Adrenal Medulla; Aging; Animals; Animals, Newborn; Brain; Chlorisondamine; Female; Guanethidine; Org | 1976 |
[Age changes in rat vasomotor reflexes and sympathetic neuron ultrastructure following chemical sympathectomy].
Topics: Aging; Animals; Guanethidine; Neurons; Rats; Reflex; Sympathetic Nervous System; Vasomotor System | 1975 |
Regional changes in brain catecholamine content following administration of guanethidine to neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Brain Stem; Catecholamines; Cerebellum; Dience | 1975 |
Age-related changes in opioid peptide concentrations in brain and pituitary of spontaneously hypertensive rats. Effect of antihypertensive drugs and comparison with deoxycorticosterone acetate and salt hypertension.
Topics: Aging; Animals; beta-Endorphin; Brain; Desoxycorticosterone; Dynorphins; Endorphins; Enkephalin, Met | 1992 |
Regional intravenous guanethidine blocks in algodystrophy.
Topics: Adult; Aged; Aging; Evaluation Studies as Topic; Extremities; Female; Guanethidine; Humans; Injectio | 1991 |
Neuropeptide Y in non-sympathetic nerves of the rat: changes during maturation but not after guanethidine sympathectomy.
Topics: Aging; Animals; Catecholamines; Guanethidine; Histocytochemistry; Immunohistochemistry; Microscopy, | 1991 |
Age-related decrease of calcitonin gene-related peptide-containing vasodilator innervation in the mesenteric resistance vessel of the spontaneously hypertensive rat.
Topics: Aging; Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Guanethidine; Hypertension; Immunoh | 1990 |
[Effect of measured chemical sympathectomy on the dynamics of the chromatin functional indices of rat sympathetic neurocytes during their differentiation].
Topics: Aging; Animals; Cell Differentiation; Cell Nucleus; DNA; Ganglia, Sympathetic; Guanethidine; Neurons | 1987 |
[Compensatory-adaptive modifications of the C-cell apparatus of the thyroid in normal rats of various ages and in partial sympathectomy].
Topics: Adaptation, Physiological; Aging; Animals; Calcitonin; Cell Count; Guanethidine; Male; Microscopy, E | 1989 |
[Indices of sympathetic neurocyte transcription and the survival indices of fractionally and partially chemically sympathectomized rats against a background of atsefen use].
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cell Nucleus; Dose-Response Relationship, Drug; G | 1988 |
Sympathetic nervous system and age-dependent salt hypertension in Brattleboro rats.
Topics: Aging; Animals; Disease Models, Animal; Female; Guanethidine; Hypertension; Male; Nephrectomy; Rats; | 1987 |
[Effect of chemical sympathectomy on the age dynamics of the heart rate and sensitivity of the heart to adrenaline and acetylcholine].
Topics: Acetylcholine; Aging; Animals; Epinephrine; Guanethidine; Heart; Heart Rate; Rats; Sympathectomy, Ch | 1987 |
The effect of prostaglandin E2 on the arterial blood pressure of normotensive and spontaneously hypertensive rats.
Topics: Acetylcholine; Aging; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, | 1974 |