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guanethidine and Aging

guanethidine has been researched along with Aging in 34 studies

Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Guanethidine treatment produced a massive sympathectomy, as synaptic vesicle development was totally arrested; the functional consequence of this treatment was confirmed by the attenuation of chronotropic responses to tyramine, a drug which acts by displacement of norepinephrine from the noradrenergic terminal."1.26Maturation of sympathetic neurotransmission in the rat heart. IV. Effects guanethidine-induced sympathectomy on neonatal development of synaptic vesicles, synaptic terminal function and heart growth. ( Bareis, DL; Lau, C; Morgan, RE; Slotkin, TA, 1981)
"Guanethidine sulfate was administered to rats from birth to 14 days of age."1.26Histologic evaluation of the sympathectomy induced by guanethidine sulfate in neonatal rats. ( Herskovits, MS; Singh, IJ, 1982)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199020 (58.82)18.7374
1990's8 (23.53)18.2507
2000's5 (14.71)29.6817
2010's1 (2.94)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Maselli, MA1
Trisolini, P1
Demma, I1
Pezzolla, F1
De Ponti, F1
Nigmatullina, RR1
Khuramshin, IG1
Nasyrova, AG1
FREIS, ED1
NUTTALL, FQ1
DOE, RP1
Nevzorova, MN1
Tiatenkova, NN1
Filimonov, VI1
Chávez-Genaro, R1
Lombide, P1
Domínguez, R1
Rosas, P1
Vázquez-Cuevas, F1
Bareis, DL1
Morgan, RE1
Lau, C1
Slotkin, TA2
Rodionov, IM3
Yarygin, VN1
Mukhammedov, A2
Manukhin, BN2
Lebedev, DB2
Nesterova, LA1
Herskovits, MS2
Singh, IJ2
Antonaccio, MJ1
Cavaliere, T1
Cote, D1
Markov, VN2
McKenzie, JC1
Klein, RM1
Iarygin, VN5
Lebedev, LB1
Milner, P2
Lincoln, J2
Belai, A1
Burnstock, G2
Zefirov, TL1
Sviatova, NV1
Takeuchi, T1
Niioka, S1
Yamaji, M1
Okishio, Y1
Ishii, T1
Nishio, H1
Takatsuji, K1
Hata, F1
Khalil, Z1
Merhi, M1
Aikawa, K1
Yokota, T1
Okamura , H1
Yamaguchi, O1
Bartolomé, J1
Bartolomé, M1
Seidler, J1
Anderson, TR1
Borisov, MM1
Doronin, PP1
Zueva, LV1
Kulaev, BS1
Nomura, Y1
Naitoh, F1
Segawa, T1
Li, SJ1
Wong, SC1
Hong, JS1
Ingenito, AJ1
Eulry, F1
Lechevalier, D1
Pats, B1
Alliaume, C1
Crozes, P1
Vasseur, P1
Coutant, G1
Felten, D1
Pattin, S1
Corr, LA1
Aberdeen, JA1
Kawasaki, H1
Saito, A1
Takasaki, K1
Chuchkova, NN1
Grigor'eva, AV2
Riashchikov, SN1
Potapov, SI1
Krecek, J1
Dolezel, S1
Dlouhá, H1
Zicha, J1
Sitdikov, FG1
Savin, VF1
Simpson, LL1

Other Studies

34 other studies available for guanethidine and Aging

ArticleYear
Gender- and age-related differences in muscular and nerve-mediated responses in human colon.
    Digestive diseases and sciences, 2011, Volume: 56, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Atropine; Carbachol; Colon; Dose-Response Relationship, Drug; Electr

2011
[Effect of sympathectomy on the heart pump function in rats during postnatal ontogenesis].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2002, Volume: 88, Issue:12

    Topics: Aging; Animals; Animals, Newborn; Blood Volume; Coronary Circulation; Guanethidine; Heart; Heart Rat

2002
OFFICE EVALUATION OF THE HYPERTENSIVE PATIENT. II.
    Modern concepts of cardiovascular disease, 1963, Volume: 32

    Topics: Aging; Blood Pressure; Blood Pressure Determination; Central Nervous System; Diuretics; Fundus Oculi

1963
THE ACHILLES REFLEX IN THYROID DISORDERS; A CRITICAL EVALUATION.
    Annals of internal medicine, 1964, Volume: 61

    Topics: Achilles Tendon; Adrenocorticotropic Hormone; Aging; Anemia; Anemia, Pernicious; Aspirin; Cold Tempe

1964
[Morphometric characteristics of microcirculatory bed of olfactory bulbs in the desympathized albino rat].
    Morfologiia (Saint Petersburg, Russia), 2004, Volume: 125, Issue:3

    Topics: Aging; Alkaline Phosphatase; Animals; Animals, Newborn; Endothelium, Vascular; Guanethidine; Microci

2004
Sympathetic pharmacological denervation in ageing rats: effects on ovulatory response and follicular population.
    Reproduction, fertility, and development, 2007, Volume: 19, Issue:8

    Topics: Aging; Animals; Estrous Cycle; Female; Gonadotropins; Guanethidine; Multivariate Analysis; Norepinep

2007
Maturation of sympathetic neurotransmission in the rat heart. IV. Effects guanethidine-induced sympathectomy on neonatal development of synaptic vesicles, synaptic terminal function and heart growth.
    Developmental neuroscience, 1981, Volume: 4, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Female; Guanethidine; Heart; Heart Rate; Male; Muscles; Organ Size

1981
Growth of sympathetic postganglionic axons after partial chemical destruction with guanethidine.
    Pflugers Archiv : European journal of physiology, 1981, Volume: 392, Issue:2

    Topics: Aging; Animals; Axons; Ganglia, Sympathetic; Guanethidine; Male; Norepinephrine; Rats; Sympathectomy

1981
Effect of guanethidine-induced sympathectomy on osteoblastic activity in the rat femur evaluated by 3H-proline autoradiography.
    Acta anatomica, 1984, Volume: 120, Issue:3

    Topics: Aging; Animals; Autoradiography; Female; Femur; Guanethidine; Male; Osteoblasts; Proline; Rats; Rats

1984
Ontogenesis of hypertension and responsiveness to antihypertensive agents in spontaneously hypertensive rats.
    Blood vessels, 1980, Volume: 17, Issue:2

    Topics: Aging; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Guanethidine; Heart Rate; Hypertensi

1980
[Cytological analysis of sympathetic neurons of 1- and 5-month-old normal rats and rats subjected to partial sympathectomy].
    Biulleten' eksperimental'noi biologii i meditsiny, 1982, Volume: 93, Issue:1

    Topics: Aging; Animals; Cell Count; Ganglia, Sympathetic; Guanethidine; Rats; Sympathectomy, Chemical

1982
Effects of guanethidine-induced sympathectomy on morphology of the pre- and postclosure ileum of the neonatal rat.
    The American journal of anatomy, 1982, Volume: 164, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Epithelial Cells; Guanethidine; Ileum; Microscopy, Electron; Micro

1982
Histologic evaluation of the sympathectomy induced by guanethidine sulfate in neonatal rats.
    The Journal of experimental zoology, 1982, Sep-20, Volume: 223, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Ganglia, Sympathetic; Guanethidine; Neurons; Rats; Sy

1982
[Age-related changes in the sympathetic innervation of effector organs in the rat after partial sympathectomy with guanethidine].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1982, Volume: 68, Issue:9

    Topics: Adrenergic Fibers; Aging; Animals; Autonomic Fibers, Preganglionic; Cell Count; Electrophysiology; G

1982
[Autoradiographic analysis of the migration of slowly translocating protein into the axons of sympathetic neurocytes of normally developing and sympathectomized mice of different ages].
    Tsitologiia, 1980, Volume: 22, Issue:3

    Topics: Aging; Animals; Autoradiography; Axons; Guanethidine; Mice; Proteins; Sympathetic Nervous System

1980
Plasticity in the myenteric plexus of the rat ileum after long-term sympathectomy.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1995, Volume: 13, Issue:5

    Topics: Adrenergic Fibers; Aging; Animals; Animals, Newborn; Guanethidine; Ileum; Immunohistochemistry; Musc

1995
[Age-related vagal regulation features of chronotropic heart function in sympathectomized and intact rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1997, Volume: 123, Issue:6

    Topics: Aging; Animals; Electric Stimulation; Electrocardiography; Female; Guanethidine; Heart; Heart Rate;

1997
Decrease in participation of nitric oxide in nonadrenergic, noncholinergic relaxation of rat intestine with age.
    Japanese journal of pharmacology, 1998, Volume: 78, Issue:3

    Topics: Adrenergic Agents; Aging; Animals; Arginine; Atropine; Colon; Electric Stimulation; Enzyme Inhibitor

1998
[Monoamine level, M-cholino-, and beta-adrenergic reception in the cranial cervical sympathetic ganglion during ontogenesis in desympathectomized rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1999, Volume: 127, Issue:4

    Topics: Aging; Animals; Biogenic Monoamines; Guanethidine; Histocytochemistry; Male; Rats; Receptors, Adrene

1999
Effects of aging on neurogenic vasodilator responses evoked by transcutaneous electrical nerve stimulation: relevance to wound healing.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2000, Volume: 55, Issue:6

    Topics: Aging; Animals; Guanethidine; Male; Peripheral Nervous System; Phentolamine; Rats; Rats, Sprague-Daw

2000
Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the changes with aging.
    The Prostate, 2001, Jun-15, Volume: 48, Issue:1

    Topics: Aging; Aminoquinolines; Animals; Arginine; Atropine; Electric Stimulation; Guanethidine; Histocytoch

2001
Effects of early postnatal guanethidine administration on adrenal medulla and brain of developing rats.
    Biochemical pharmacology, 1976, Nov-01, Volume: 25, Issue:21

    Topics: Adrenal Medulla; Aging; Animals; Animals, Newborn; Brain; Chlorisondamine; Female; Guanethidine; Org

1976
[Age changes in rat vasomotor reflexes and sympathetic neuron ultrastructure following chemical sympathectomy].
    Biulleten' eksperimental'noi biologii i meditsiny, 1975, Volume: 79, Issue:6

    Topics: Aging; Animals; Guanethidine; Neurons; Rats; Reflex; Sympathetic Nervous System; Vasomotor System

1975
Regional changes in brain catecholamine content following administration of guanethidine to neonatal rats.
    Japanese journal of pharmacology, 1975, Volume: 25, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Brain Stem; Catecholamines; Cerebellum; Dience

1975
Age-related changes in opioid peptide concentrations in brain and pituitary of spontaneously hypertensive rats. Effect of antihypertensive drugs and comparison with deoxycorticosterone acetate and salt hypertension.
    Pharmacology, 1992, Volume: 44, Issue:5

    Topics: Aging; Animals; beta-Endorphin; Brain; Desoxycorticosterone; Dynorphins; Endorphins; Enkephalin, Met

1992
Regional intravenous guanethidine blocks in algodystrophy.
    Clinical rheumatology, 1991, Volume: 10, Issue:4

    Topics: Adult; Aged; Aging; Evaluation Studies as Topic; Extremities; Female; Guanethidine; Humans; Injectio

1991
Neuropeptide Y in non-sympathetic nerves of the rat: changes during maturation but not after guanethidine sympathectomy.
    Neuroscience, 1991, Volume: 43, Issue:2-3

    Topics: Aging; Animals; Catecholamines; Guanethidine; Histocytochemistry; Immunohistochemistry; Microscopy,

1991
Age-related decrease of calcitonin gene-related peptide-containing vasodilator innervation in the mesenteric resistance vessel of the spontaneously hypertensive rat.
    Circulation research, 1990, Volume: 67, Issue:3

    Topics: Aging; Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Guanethidine; Hypertension; Immunoh

1990
[Effect of measured chemical sympathectomy on the dynamics of the chromatin functional indices of rat sympathetic neurocytes during their differentiation].
    Tsitologiia, 1987, Volume: 29, Issue:6

    Topics: Aging; Animals; Cell Differentiation; Cell Nucleus; DNA; Ganglia, Sympathetic; Guanethidine; Neurons

1987
[Compensatory-adaptive modifications of the C-cell apparatus of the thyroid in normal rats of various ages and in partial sympathectomy].
    Arkhiv anatomii, gistologii i embriologii, 1989, Volume: 97, Issue:11

    Topics: Adaptation, Physiological; Aging; Animals; Calcitonin; Cell Count; Guanethidine; Male; Microscopy, E

1989
[Indices of sympathetic neurocyte transcription and the survival indices of fractionally and partially chemically sympathectomized rats against a background of atsefen use].
    Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 105, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cell Nucleus; Dose-Response Relationship, Drug; G

1988
Sympathetic nervous system and age-dependent salt hypertension in Brattleboro rats.
    Clinical and experimental hypertension. Part A, Theory and practice, 1987, Volume: 9, Issue:12

    Topics: Aging; Animals; Disease Models, Animal; Female; Guanethidine; Hypertension; Male; Nephrectomy; Rats;

1987
[Effect of chemical sympathectomy on the age dynamics of the heart rate and sensitivity of the heart to adrenaline and acetylcholine].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1987, Volume: 73, Issue:1

    Topics: Acetylcholine; Aging; Animals; Epinephrine; Guanethidine; Heart; Heart Rate; Rats; Sympathectomy, Ch

1987
The effect of prostaglandin E2 on the arterial blood pressure of normotensive and spontaneously hypertensive rats.
    British journal of pharmacology, 1974, Volume: 51, Issue:4

    Topics: Acetylcholine; Aging; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship,

1974