guanethidine has been researched along with Adjuvant Arthritis in 2 studies
Guanethidine: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
guanethidine : A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
guanethidine sulfate : A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The putative antinociceptive action of guanethidine and calcitonin systemically injected has been compared in 2 rat models of persistent experimental pain: Freund's adjuvant-induced arthritis (n = 29) and mononeuropathy induced by 4 loose ligatures around the sciatic nerve (n = 24)." | 3.68 | Are mechanical and cold allodynia in mononeuropathic and arthritic rats relieved by systemic treatment with calcitonin or guanethidine? ( Ardid, D; Attal, N; Guilbaud, G; Perrot, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sato, J | 1 |
| Suzuki, S | 1 |
| Tamura, R | 1 |
| Kumazawa, T | 1 |
| Perrot, S | 1 |
| Attal, N | 1 |
| Ardid, D | 1 |
| Guilbaud, G | 1 |
2 other studies available for guanethidine and Adjuvant Arthritis
| Article | Year |
|---|---|
Norepinephrine excitation of cutaneous nociceptors in adjuvant-induced inflamed rats does not depend on sympathetic neurons.
Topics: Adrenergic alpha-Antagonists; Animals; Arthritis, Experimental; Berberine; Guanethidine; Male; Neura | 1994 |
Are mechanical and cold allodynia in mononeuropathic and arthritic rats relieved by systemic treatment with calcitonin or guanethidine?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Arthritis, Experimental; Be | 1993 |