guanabenz and Hypertension

guanabenz has been researched along with Hypertension in 91 studies

*Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. [MeSH]

Research

Studies (91)

Timeframe	Studies, this research(%)	All Research%
pre-1990	72 (79.12)	18.7374
1990's	10 (10.99)	18.2507
2000's	9 (9.89)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Hargreaves, RT; Warren, JD; Woodward, DL	1
Jin, X; Kim, JH; Kim, SH; Park, BH; Park, WH; Yuan, K	1
Paul, IA; Peeler, DF; Piletz, JE; Stec, DE; Zhu, H	1
Head, GA	1
Aoki, Y; Araki, T; Chonan, K; Hashimoto, J; Hozawa, A; Imai, Y; Kikuya, M; Matsubara, M; Michimata, M; Nishimura, T; Ohkubo, T; Ugajin, T; Yamaguchi, J	1
Takishita, S; Yamazato, M	1
Sica, DA	1
Lappe, RW; Saslow, BA; Wendt, RL	1
Cervenka, J; Mosley, C; O'Connor, DT; Slutsky, RA; Taylor, A	1
Garg, DC; Jallad, NS; Weidler, DJ	1
Buckalew, VM; Eldridge, JC; Strandhoy, J	1
Drayer, JI; Weber, MA	3
Morgan, TO	1
Deitch, MW; Graves, P; Kilbourne, K; Rath, A; Walson, PD	1
Deitch, MW; Drayer, JI; Weber, MA	1
Kaplan, NM	2
McCarron, DA	1
Frova, C	1
Houston, MC	1
Finnerty, FA	1
Insel, PA; Motulsky, HJ; O'Connor, DT	1
Hamilton, CA; Reid, JL	1
Dziedzic, SW; Elijovich, F; Felton, K; Krakoff, LR; Yeager, K	1
Grenfell, RF	1
Avery, GS; Brogden, RN; Heel, RC; Holmes, B; Speight, TM	1
Bevilacqua, M; Meroni, R; Norbiato, G; Scorza, D; Vago, T	1
Agabiti-Rosei, E; Alicandri, C; Fariello, R; Muiesan, G; Renzetti, I; Romanelli, G	1
Delle Gemme, E; Dessì-Fulgheri, P; Glorioso, N; Madeddu, P; Rappelli, A	1
Antognetti, R; Giovine, GG	1
Frisina, N; Macrì, I; Ussi, F	1
Delle Gemme, E; Misceo, N; Pieri, A; Pirrelli, A; Stella, M; Strippoli, M	1
Masoni, C; Pirani, R; Tomasi, AM	1
Chiang, ST; Emmett, M; Goldberg, M; Kyriakopoulos, AA; Meacham, RH; Narins, RG; Ruelius, HW; Walker, BR	2
Amodio, P; Casiglia, E; Frigo, A; Gatta, A; Hlede, M; Merkel, C; Milani, L; Palatini, P; Pessina, AC; Semplicini, A	1
Argentieri, M; Mazzanti, A	1
Patola, R; Storti, R	1
Alessandrini, A; Bianchi, RM; Legnani, W; Renzetti, I	1
Gehr, M; Goldberg, M; MacCarthy, EP	1
Deitch, MW; Kilbourne, K; Rath, A; Walson, PD	1
Bauer, JH	1
De Ridder, JH; Marchandise, P	1
Chiarini, C; Degli Esposti, E; Gattiani, A; Sturani, A; Zuccalá, A	1
Kluyskens, Y; Snoeck, J	1
Fairchild, C; Gomez-Sanchez, CE; Holland, OB	1
Deitch, MW; Gold, JA; Levey, BA; Walker, BR	1
Rosendorff, C	1
Cavellat, M; Chapillon, M; Delhumeau, A; Leboulanger, J	1
Deitch, MW; Gold, JA; Hare, LE; Schneider, BE; Walker, BR	1
Deitch, MW; Hare, LE; Schneider, BE; Walker, BR	1
Kick, CJ; Kocmund, SM; Meacham, RH; Peters, JR; Ruelius, HW; Sisenwine, SF; Wendt, RL	1
Gold, JA; Rudnick, MR; Schneider, BE; Walker, BR	1
Cloix, JF; Dausse, JP; Le Jossec, M	1
Huang, BS; Leenen, FH	5
Fujita, H; Itoh, H; Nakamura, K; Nakata, T; Sasaki, S; Takeda, K; Takenaka, K; Uchida, A; Yoneda, Y; Yoshitomi, T	1
Endo, T; Hishiki, S; Kawano, Y; Miyajima, E; Shigemasa, T	1
Leenen, FH; Zhang, J	1
Huang, BS; Leenen, FH; Wang, H	1
Jain, AK; McMahon, FG; Ryan, JR; Vanov, SK; Vargas, R	1
Helfant, RH; Ramanathan, KB; Shah, RS; Vanov, SK; Walker, BR	1
Orth, H; Ritz, E; Tschöpe, W	1
Asmal, AC; Leary, WP; Williams, PC	1
Campus, S; Dessì Fulgheri, P; Glorioso, N; Madeddu, P; Rappelli, A; Tedde, R	1
Helfant, RH; Shah, RS; Vanov, SK; Walker, BR	1
Di Veroli, C; Petrucci, D	1
Chiummo, R	1
Abdel-Rahman, AA; Carroll, RG; el-Mas, MM	1
DiBona, GF; Jones, SY	1
Baez, MA; Deitch, MW; Garg, DC; Shapse, DB; Weidler, DJ; Woo-Ming, RB	1
Gehr, M; Goldberg, M	1
Pandhi, P; Sharma, PL	1
DiBona, GF; Johnson, AK; Kapusta, DR; Knardahl, S; Koepke, JP	1
DiBona, GF; Jones, S; Koepke, JP	2
DiBona, GF; Koepke, JP	1
Grundy, S; Kaplan, NM	1
Baso, B; Gac, JC; Román, O; Sudy, E; Valenzuela, MA	1
Rodrigues, R; Spritzer, N; Spritzer, TS	1
Hayashi, S; Nishio, S; Yoshihara, H	1
Jessup, SA; LaRusso, P; Rogers, FJ; Rogers, JC	1
Alvis, R; Braden, G; Cox, M; Walker, BR	1
Blackshear, JL; Fillingim, JM; Strauss, A; Strauss, M	1
DeCola, P; Dubrow, A; Flamenbaum, W; Mittman, N; Westerman, M	1

Reviews

7 review(s) available for guanabenz and Hypertension

Article	Year
Therapeutic effects of evening administration of guanabenz and clonidine on morning hypertension. Journal of hypertension, 2003, Volume: 21, Issue:4 Topics: Antihypertensive Agents; Circadian Rhythm; Clonidine; Guanabenz; Humans; Hypertension	2003
[Centrally-acting antihypertensive drugs]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3 Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Guanabenz; Guanfacine; Humans; Hypertension; Imidazoline Receptors; Kidney; Methyldopa; Norepinephrine; Pressoreceptors; Receptors, Drug; Renal Circulation; Sodium; Sympathetic Nervous System; Sympatholytics; Vascular Resistance	2004
Centrally acting antihypertensive agents: an update. Journal of clinical hypertension (Greenwich, Conn.), 2007, Volume: 9, Issue:5 Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Pressure; Clonidine; Contraindications; Guanabenz; Guanfacine; Humans; Hypertension; Imidazoles; Methyldopa; Oxazoles; Rilmenidine	2007
Centrally acting antihypertensive agents: a brief overview. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5 Topics: Animals; Antihypertensive Agents; Central Nervous System; Clonidine; Guanabenz; Humans; Hypertension; Methyldopa; Reserpine; Sympathetic Nervous System	1984
Abrupt cessation of treatment in hypertension: consideration of clinical features, mechanisms, prevention and management of the discontinuation syndrome. American heart journal, 1981, Volume: 102, Issue:3 Pt 1 Topics: Acute Disease; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Bethanidine; Blood Pressure; Clonidine; Guanabenz; Heart Failure; Humans; Hypertension; Methyldopa; Myocardial Infarction; Pressoreceptors; Prospective Studies; Substance Withdrawal Syndrome; Syndrome; Time Factors	1981
Central and peripheral blockade of the sympathetic nervous system. The American journal of medicine, 1984, Oct-05, Volume: 77, Issue:4A Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Clonidine; Diuretics; Drug Therapy, Combination; Guanabenz; Humans; Hypertension; Indoramin; Labetalol; Methyldopa; Prazosin; Quinazolines; Reserpine; Sympathetic Nervous System; Sympatholytics	1984
Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension. Drugs, 1983, Volume: 26, Issue:3 Topics: Animals; Guanabenz; Guanidines; Hemodynamics; Humans; Hypertension; Protein Binding; Tissue Distribution	1983

Trials

30 trial(s) available for guanabenz and Hypertension

Article	Year
Therapeutic effects of evening administration of guanabenz and clonidine on morning hypertension: evaluation using home-based blood pressure measurements. Journal of hypertension, 2003, Volume: 21, Issue:4 Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Circadian Rhythm; Clonidine; Female; Guanabenz; Heart Rate; Humans; Hypertension; Male; Middle Aged; Treatment Outcome	2003
Comparative effects of antihypertensive therapy with guanabenz and propranolol on renal vascular resistance and left ventricular mass. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5 Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Double-Blind Method; Guanabenz; Guanidines; Heart; Humans; Hypertension; Male; Middle Aged; Myocardial Contraction; Propranolol; Renal Circulation; Vascular Resistance	1984
Dose-response relationship of single oral doses of guanabenz in hypertensive patients. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5 Topics: Administration, Oral; Adult; Aged; Blood Pressure; Dose-Response Relationship, Drug; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Middle Aged; Pulse	1984
Endocrinologic effects of antihypertensive therapy with guanabenz or hydrochlorothiazide. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5 Topics: Adult; Aged; Antihypertensive Agents; Double-Blind Method; Endocrine System Diseases; Female; Glucagon; Growth Hormone; Guanabenz; Guanidines; Humans; Hydrochlorothiazide; Hypertension; Insulin; Male; Middle Aged; Prolactin; Radioimmunoassay	1984
Step-one antihypertensive therapy: a comparison of a centrally acting agent and a diuretic. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5 Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Guanabenz; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Random Allocation; Risk	1984
Guanabenz (Wytensin) a new antihypertensive drug. The Medical letter on drugs and therapeutics, 1983, Jan-21, Volume: 25, Issue:627 Topics: Clinical Trials as Topic; Guanabenz; Guanidines; Humans; Hypertension	1983
Effect of guanabenz on blood pressure responses to posture and exercise. Clinical pharmacology and therapeutics, 1983, Volume: 33, Issue:2 Topics: Adult; Blood Pressure; Drug Evaluation; Epinephrine; Female; Guanabenz; Guanidines; Heart Rate; Humans; Hypertension; Male; Norepinephrine; Physical Exertion; Posture; Renin	1983
Double-blind study of guanabenz acetate in hypertensive patients. Southern medical journal, 1983, Volume: 76, Issue:2 Topics: Adult; Aged; Blood Pressure; Blood Pressure Determination; Clinical Trials as Topic; Double-Blind Method; Guanabenz; Guanidines; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Posture; Random Allocation; Time Factors	1983
[Clinical and statistical considerations on a new drug in the therapy of arterial hypertension. Controlled study]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Drug Therapy, Combination; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Mefruside; Middle Aged	1984
[Treatment of arterial hypertension with a new drug combining guanabenz-mefruside]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Mefruside; Middle Aged	1984
[Clinical use of various dosages of a centrally acting hypotensive drug associated with a diuretic]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Drug Combinations; Drug Tolerance; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Mefruside; Middle Aged	1984
[Treatment of idiopathic hypertension with guanabenz-mefruside]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Dose-Response Relationship, Drug; Drug Combinations; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Mefruside; Middle Aged	1984
[The antihypertensive effect of 2,6-dichloro-benzylidene-aminoguanidine acetate (Guanabenz)]. Giornale di clinica medica, 1980, Volume: 61, Issue:3 Topics: Adult; Clinical Trials as Topic; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Middle Aged; Placebos	1980
Comparison of guanabenz and clonidine in hypertensive patients. Current medical research and opinion, 1980, Volume: 6, Issue:9 Topics: Adult; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Middle Aged; Pulse	1980
Effect of guanabenz and hydrochlorothiazide on blood pressure and plasma renin activity. Journal of clinical pharmacology, 1981, Volume: 21, Issue:4 Topics: Adult; Aged; Blood Pressure; Drug Therapy, Combination; Female; Guanabenz; Guanidines; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Renin	1981
Evaluation of guanabenz added to hydrochlorothiazide therapy in hypertension. The Journal of international medical research, 1982, Volume: 10, Issue:3 Topics: Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Guanabenz; Guanidines; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pulse	1982
Guanabenz versus methyldopa in the therapy of mild-to-moderate hypertension. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Sep-18, Volume: 62, Issue:13 Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Methyldopa; Middle Aged	1982
Comparative antihypertensive effects of guanabenz and methyldopa. Clinical therapeutics, 1981, Volume: 4, Issue:4 Topics: Blood Pressure; Body Weight; Double-Blind Method; Drug Evaluation; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Methyldopa; Posture; Random Allocation	1981
Effects of placebo versus guanabenz on hypertensive out-patients. The Journal of international medical research, 1980, Volume: 8, Issue:5 Topics: Adult; Aged; Blood Pressure; Double-Blind Method; Drug Evaluation; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Middle Aged; Placebos	1980
Guanabenz in essential hypertension. Clinical pharmacology and therapeutics, 1977, Volume: 21, Issue:3 Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Drug Evaluation; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Middle Aged	1977
Guanabenz and methyldopa on hypertension and cardiac performance. Clinical pharmacology and therapeutics, 1977, Volume: 22, Issue:6 Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Drug Evaluation; Female; Guanabenz; Guanidines; Hemodynamics; Humans; Hypertension; Male; Methyldopa; Middle Aged	1977
[Clinical experiences in antihypertensive treatment with guanabenz or clonidine in combination with thiazide]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1978, Issue:84 Topics: Adult; Benzothiadiazines; Clinical Trials as Topic; Clonidine; Diuretics; Drug Therapy, Combination; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Middle Aged; Sodium Chloride Symporter Inhibitors	1978
Evaluation of the efficacy and safety of guanabenz versus clonidine. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Jan-20, Volume: 55, Issue:3 Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Clonidine; Drug Evaluation; Guanabenz; Guanidines; Humans; Hypertension; Middle Aged; Pulse	1979
Guanabenz effects on blood pressure and noninvasive parameters of cardiac performance in patients with hypertension. Clinical pharmacology and therapeutics, 1976, Volume: 19, Issue:6 Topics: Adult; Aged; Blood Pressure; Cardiac Output; Clinical Trials as Topic; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Middle Aged; Placebos; Pulse; Time Factors	1976
[Controlled clinical trial of a new antihypertensive drug: 2,6-dichlorobenzylidene-amino-guanidine acetate]. La Clinica terapeutica, 1976, Feb-29, Volume: 76, Issue:4-3 Topics: Antihypertensive Agents; Clinical Trials as Topic; Clonidine; Guanabenz; Guanidines; Humans; Hypertension	1976
Dose-ranging study to delineate the additive antihypertensive effect of guanabenz and captopril. Journal of clinical pharmacology, 1991, Volume: 31, Issue:4 Topics: Administration, Oral; Adult; Blood Pressure; Captopril; Drug Synergism; Drug Therapy, Combination; Female; Guanabenz; Humans; Hypertension; Male; Middle Aged	1991
Comparison of the effects of guanabenz and hydrochlorothiazide on plasma lipids. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:3 Topics: Adult; Aged; Blood Pressure; Cholesterol; Clinical Trials as Topic; Double-Blind Method; Female; Guanabenz; Guanidines; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Prospective Studies; Random Allocation; Triglycerides	1988
[Guanabenz in primary hypertension]. Revista medica de Chile, 1988, Volume: 116, Issue:3 Topics: Blood Pressure; Cholesterol; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Middle Aged; Triglycerides	1988
[Guanabenz acetate and serum lipids. Sequential evaluation during one year]. Arquivos brasileiros de cardiologia, 1988, Volume: 51, Issue:2 Topics: Blood Pressure; Cholesterol; Clinical Trials as Topic; Female; Follow-Up Studies; Guanabenz; Guanidines; Humans; Hypertension; Lipids; Lipoproteins; Male	1988
Guanfacine as monotherapy for systemic hypertension. The American journal of cardiology, 1986, Mar-28, Volume: 57, Issue:9 Topics: Adult; Aged; Aldosterone; Cholesterol; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Guanabenz; Guanfacine; Guanidines; Humans; Hypertension; Lipoproteins; Middle Aged; Phenylacetates; Plasma Volume; Random Allocation; Sleep Stages	1986

Other Studies

54 other study(ies) available for guanabenz and Hypertension

Article	Year
4-Substituted semicarbazones of mono- and dichlorobenzaldehydes as antihypertensive agents. Journal of medicinal chemistry, 1977, Volume: 20, Issue:11 Topics: Animals; Antihypertensive Agents; Benzaldehydes; Dogs; Hypertension; Rats; Semicarbazones; Structure-Activity Relationship	1977
Modification of atrial natriuretic peptide system in cold-induced hypertensive rats. Regulatory peptides, 2009, Apr-10, Volume: 154, Issue:1-3 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Cold Temperature; Cyclic AMP; Dose-Response Relationship, Drug; Guanabenz; Heart Atria; Heart Rate; Hypertension; Isoproterenol; Male; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; RNA, Messenger; Sympathetic Nervous System; Time Factors	2009
Non-adrenergic exploratory behavior induced by moxonidine at mildly hypotensive doses. Brain research, 2003, Feb-21, Volume: 964, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Blood Pressure; Brain; Dose-Response Relationship, Drug; Epinephrine; Exploratory Behavior; Guanabenz; Hypertension; Hypotension; Imidazoles; Imidazoline Receptors; Male; Mice; Receptors, Adrenergic, alpha-2; Receptors, Drug; Sympathetic Nervous System	2003
Effects of nifedipine on the hypotensive actions of alpha 2-agonists in conscious spontaneously hypertensive rats. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5 Topics: Administration, Oral; Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Drug Interactions; Guanabenz; Hypertension; Injections, Intravenous; Injections, Intraventricular; Male; Nifedipine; Rats; Rats, Inbred SHR	1984
Comparison of a centrally acting antihypertensive agent and beta-adrenergic blocking agents for the treatment of hypertension. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Female; Guanabenz; Humans; Hypertension; Male; Middle Aged; Pindolol; Potassium; Propranolol; Pulse; Time Factors	1984
Effects of guanabenz in adolescent hypertension. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5 Topics: Adolescent; Adult; Blood Pressure; Child; Echocardiography; Guanabenz; Guanidines; Humans; Hypertension; Male; Pulse	1984
Hypertension in patients with diabetes mellitus: treatment with a centrally acting agent. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5 Topics: Adult; Aged; Blood Glucose; Blood Pressure; Cholesterol; Diabetes Complications; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Middle Aged; Pulse	1984
Effects of guanabenz on plasma lipid levels in hypertensive patients. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5 Topics: Adult; Aged; Cholesterol; Female; Guanabenz; Guanidines; Humans; Hypertension; Lipids; Lipoproteins; Male; Middle Aged; Time Factors; Triglycerides	1984
[Pharmacologic profile of guanabenz]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Guanabenz; Guanidines; Humans; Hypertension; Receptors, Adrenergic, alpha	1984
Office management of hypertension. Comprehensive therapy, 1984, Volume: 10, Issue:2 Topics: Adrenergic beta-Antagonists; Aged; Ambulatory Care; Antihypertensive Agents; Benzothiadiazines; Captopril; Clonidine; Diuretics; Guanabenz; Humans; Hydralazine; Hypertension; Methyldopa; Middle Aged; Prazosin; Reserpine; Sodium Chloride Symporter Inhibitors	1984
Platelet alpha 2-adrenergic receptors in treated and untreated essential hypertension. Clinical science (London, England : 1979), 1983, Volume: 64, Issue:3 Topics: Adult; Blood Platelets; Guanabenz; Humans; Hypertension; Male; Middle Aged; Platelet Aggregation; Propranolol; Radioligand Assay; Receptors, Adrenergic; Receptors, Adrenergic, alpha	1983
alpha-Adrenoceptors and hypertension. Biochemical Society transactions, 1982, Volume: 10, Issue:6 Topics: Animals; Catecholamines; Guanabenz; Hypertension; Phenylephrine; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha	1982
[Effects of guanabenz on plasma renin and aldosterone and on sodium balance in hypertensive patients]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Adult; Aldosterone; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Middle Aged; Renin; Sodium	1984
[Effect of guanabenz, alpha 2 central agonist, on the activity of the sympathetic nervous system during dynamic and isometric physical exercise]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Adult; Blood Pressure; Exercise Test; Female; Guanabenz; Guanidines; Heart Rate; Humans; Hypertension; Isometric Contraction; Male; Middle Aged; Norepinephrine; Renin	1984
[Effect of guanabenz alone and in association with a diuretic on blood pressure and on the renin-angiotensin-aldosterone system in hypertensive patients]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Adult; Aged; Aldosterone; Chlorthalidone; Drug Therapy, Combination; Guanabenz; Guanidines; Heart Rate; Humans; Hypertension; Middle Aged; Renin; Renin-Angiotensin System	1984
[Availability of 14C-guanabenz in patients with idiopathic hypertension]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Adult; Aged; Biological Availability; Carbon Radioisotopes; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Middle Aged	1984
[Antihypertensive action and renal effects of guanabenz]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Adult; Guanabenz; Guanidines; Humans; Hypertension; Kidney; Middle Aged	1984
[Efficacy and tolerance of guanabenz in patients with associated chronic cardio-circulatory, respiratory, infectious and metabolic diseases]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Aged; Angina Pectoris; Arterial Occlusive Diseases; Arthritis; Bronchopneumonia; Chronic Disease; Diabetes Complications; Drug Tolerance; Female; Guanabenz; Guanidines; Heart Failure; Humans; Hypertension; Male; Middle Aged; Urinary Tract Infections	1984
[Guanabenz in hypertension in the aged]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Aged; Guanabenz; Guanidines; Humans; Hypertension; Middle Aged; Posture	1984
[Effects of the short-term administration of a new preparation in the treatment of arterial hypertension]. Minerva cardioangiologica, 1984, Volume: 32, Issue:5 Topics: Aged; Diuretics; Drug Evaluation; Drug Therapy, Combination; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Mefruside; Middle Aged	1984
Natriuretic and water diuretic effects of guanabenz, a central alpha-2 agonist. Transactions of the American Clinical and Climatological Association, 1984, Volume: 95 Topics: Adult; Diuresis; Drug Evaluation; Guanabenz; Guanidines; Hemodynamics; Humans; Hypertension; Kidney; Male; Middle Aged; Natriuresis; Time Factors	1984
Guanabenz for adolescent hypertension. Pediatric pharmacology (New York, N.Y.), 1984, Volume: 4, Issue:1 Topics: Adolescent; Adult; Blood Pressure; Child; Drug Evaluation; Guanabenz; Guanidines; Headache; Humans; Hypertension; Male; Pulse	1984
Effects of guanabenz therapy on renal function and body fluid composition. Archives of internal medicine, 1983, Volume: 143, Issue:6 Topics: Blood Pressure; Blood Pressure Determination; Body Fluids; Dose-Response Relationship, Drug; Drug Evaluation; Glomerular Filtration Rate; Guanabenz; Guanidines; Hemodynamics; Humans; Hypertension; Kidney; Male; Middle Aged; Prospective Studies; Pulse; Vascular Resistance	1983
Preliminary clinical trial with a new hypotensive, guanabenz, in a group of hypertensive patients. Acta cardiologica, 1980, Volume: 35, Issue:5 Topics: Aged; Amiloride; Blood Pressure; Drug Evaluation; Drug Tolerance; Female; Guanabenz; Guanidines; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged	1980
[Single dose of thiopental or fentanyl. Hemodynamic effects after treatment by an anti-hypertensive drug: guanoxabenz (author's transl)]. Anesthesie, analgesie, reanimation, 1981, Volume: 38, Issue:3-4 Topics: Aged; Antihypertensive Agents; Craniocerebral Trauma; Drug Interactions; Fentanyl; Guanabenz; Guanidines; Hemodynamics; Humans; Hypertension; Middle Aged; Thiopental	1981
Long-term therapy of hypertension with guanabenz. Clinical therapeutics, 1981, Volume: 4, Issue:3 Topics: Adult; Aged; Body Weight; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Middle Aged; Pulse; Time Factors	1981
Disposition of 14C-guanabenz in patients with essential hypertension. Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:1 Topics: Adult; Aged; Glucuronates; Guanabenz; Guanidines; Half-Life; Humans; Hypertension; Kinetics; Middle Aged	1980
Relationship of guanabenz concentrations in brain and plasma to antihypertensive effect in the spontaneously hypertensive rat. The Journal of pharmacology and experimental therapeutics, 1980, Volume: 214, Issue:3 Topics: Animals; Blood Pressure; Brain; Dose-Response Relationship, Drug; Guanabenz; Guanidines; Heart Rate; Hypertension; Male; Rats	1980
[Evidence for two alpha 2B-adrenoreceptor isoforms in the renal cortex of salt-sensitive and salt resistant Sabra rats. Effect of salt loading]. Archives des maladies du coeur et des vaisseaux, 1995, Volume: 88, Issue:8 Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Guanabenz; Hypertension; Kidney Cortex; Male; Oxymetazoline; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Sodium, Dietary; Yohimbine	1995
Blockade of brain "ouabain" prevents sympathoexcitatory and pressor responses to high sodium in SHR. The American journal of physiology, 1996, Volume: 271, Issue:1 Pt 2 Topics: Air; Animals; Blood Pressure; Brain; Diet, Sodium-Restricted; Guanabenz; Hypertension; Immunoglobulin Fab Fragments; Injections, Intraventricular; Male; Ouabain; Physical Stimulation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sympathetic Nervous System	1996
Brain "ouabain" and angiotensin II in salt-sensitive hypertension in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979), 1996, Volume: 28, Issue:6 Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Brain; Guanabenz; Hemodynamics; Hypertension; Imidazoles; Immunoglobulin Fab Fragments; Injections, Intraventricular; Losartan; Male; Ouabain; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Sodium Chloride, Dietary; Tetrazoles	1996
Role of baroreflex and central alpha2-adrenergic receptor systems in the diurnal variation of blood pressure and heart rate in normotensive and hypertensive rats. Clinical and experimental pharmacology & physiology. Supplement, 1995, Volume: 22, Issue:1 Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Baroreflex; Blood Pressure; Circadian Rhythm; Denervation; Guanabenz; Heart Rate; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Sinoatrial Node	1995
Both brain angiotensin II and "ouabain" contribute to sympathoexcitation and hypertension in Dahl S rats on high salt intake. Hypertension (Dallas, Tex. : 1979), 1998, Volume: 32, Issue:6 Topics: Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Body Weight; Brain; Cardiotonic Agents; Guanabenz; Hemodynamics; Hypertension; Nitroprusside; Ouabain; Phenylephrine; Rats; Rats, Inbred Dahl; Sodium Chloride; Stress, Physiological	1998
Brain renin-angiotensin system and ouabain-induced sympathetic hyperactivity and hypertension in Wistar rats. Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:1 Topics: Angiotensin II; Animals; Antihypertensive Agents; Arteries; Baroreflex; Brain; Guanabenz; Heart; Hypertension; Injections, Intraventricular; Kidney; Lung; Male; Nervous System Diseases; Ouabain; Rats; Rats, Wistar; Renin-Angiotensin System; Stress, Physiological; Sympathetic Nervous System	1999
Guanabenz combination therapy inhibits sympathetic nerve activity and regresses left ventricular hypertrophy. Cardiovascular drugs and therapy, 2000, Volume: 14, Issue:1 Topics: Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Female; Guanabenz; Heart Rate; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Norepinephrine; Organ Size; Sympathetic Nervous System; Sympatholytics	2000
AT(1) receptor blockers prevent sympathetic hyperactivity and hypertension by chronic ouabain and hypertonic saline. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:3 Topics: Air Movements; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Chronic Disease; Guanabenz; Heart Rate; Hypertension; Injections, Intraventricular; Losartan; Male; Ouabain; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Saline Solution, Hypertonic; Stress, Physiological; Sympathetic Nervous System; Vasoconstrictor Agents	2001
Enhanced sympathoexcitatory and pressor responses to central Na+ in Dahl salt-sensitive vs. -resistant rats. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:5 Topics: Adrenergic alpha-Agonists; Age Factors; Animals; Baroreflex; Blood Pressure; Brain; Guanabenz; Heart Rate; Hypertension; Injections, Intraventricular; Kidney; Male; Ouabain; Potassium; Rats; Rats, Inbred Dahl; Rats, Wistar; Sodium; Sodium, Dietary; Sympathetic Nervous System	2001
[Effect of guanabenz on arterial pressure and the renin-aldosterone system in hypertensive patients]. Bollettino della Societa italiana di cardiologia, 1978, Volume: 23, Issue:1 Topics: Adult; Aged; Aldosterone; Blood Pressure; Guanabenz; Guanidines; Heart Rate; Humans; Hypertension; Hypertension, Renal; Hypertension, Renovascular; Middle Aged; Renin	1978
[Antihypertensive activity of a new molecule, 2,6-dichloro-benzylidene aminoguanidine acetate]. Minerva medica, 1975, Dec-08, Volume: 66, Issue:84 Topics: Aged; Antihypertensive Agents; Drug Evaluation; Female; Guanabenz; Guanidines; Humans; Hypertension; Male; Methyldopa; Middle Aged	1975
Role of the sympathetic nervous system in the alcohol-guanabenz hemodynamic interaction. Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:9 Topics: Animals; Antihypertensive Agents; Blood Pressure; Catecholamines; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Guanabenz; Heart Rate; Hemodynamics; Hexamethonium; Hexamethonium Compounds; Hypertension; Hypotension; Male; Nitroprusside; Rats; Rats, Inbred SHR; Sympathetic Nervous System	1992
Central alpha 2-adrenoceptor responsiveness in borderline hypertensive rats. Journal of hypertension, 1991, Volume: 9, Issue:6 Topics: Animals; Brain; Guanabenz; Hypertension; Kidney; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Sodium, Dietary	1991
Brain ouabain and central effects of dietary sodium in spontaneously hypertensive rats. Circulation research, 1992, Volume: 70, Issue:2 Topics: Animals; Blood Pressure; Brain; Diet; Guanabenz; Heart Rate; Hypertension; Injections, Intraventricular; Kidney; Male; Ouabain; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rest; Sodium; Stress, Psychological; Sympathetic Nervous System	1992
Effects of alpha-2 agonists on renal function in hypertensive humans. Journal of cardiovascular pharmacology, 1985, Volume: 7 Suppl 8 Topics: Adrenergic alpha-Agonists; Clonidine; Diuresis; Glomerular Filtration Rate; Guanabenz; Humans; Hypertension; Kidney; Methyldopa; Natriuresis	1985
Alpha 2-adrenoceptor agonists in the treatment of hypertension. Journal of cardiovascular pharmacology, 1985, Volume: 7 Suppl 8 Topics: Adrenergic alpha-Agonists; Clonidine; Diuretics; Drug Therapy, Combination; Guanabenz; Humans; Hypertension; Lipids; Methyldopa	1985
Progress in the treatment of essential hypertension. International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23 Suppl 1 Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Clonidine; Diuretics; Drug Therapy, Combination; Guanabenz; Humans; Hypertension; Methyldopa; Vasodilator Agents	1985
Selective central alpha-2 adrenoceptor control of regional haemodynamic responses to air jet stress in conscious spontaneously hypertensive rats. Journal of hypertension, 1989, Volume: 7, Issue:3 Topics: Animals; Aorta, Abdominal; Blood Pressure; Central Nervous System; Guanabenz; Hypertension; Male; Mesenteric Arteries; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Renal Artery; Stress, Physiological; Vascular Resistance	1989
Sodium responsiveness of central alpha 2-adrenergic receptors in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979), 1988, Volume: 11, Issue:4 Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Central Nervous System; Denervation; Diuresis; Dose-Response Relationship, Drug; Guanabenz; Hypertension; Injections, Intraventricular; Kidney; Natriuresis; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Sodium, Dietary; Sympathetic Nervous System; Yohimbine	1988
Central adrenergic receptor control of renal function in conscious hypertensive rats. Hypertension (Dallas, Tex. : 1979), 1986, Volume: 8, Issue:2 Topics: Animals; Blood Pressure; Clonidine; Guanabenz; Hypertension; Kidney; Male; Natriuresis; Phenoxybenzamine; Prazosin; Rats; Rats, Inbred SHR; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Urodynamics; Yohimbine	1986
Alpha 2-adrenoceptors in amygdala control renal sympathetic nerve activity and renal function in conscious spontaneously hypertensive rats. Brain research, 1987, Feb-24, Volume: 404, Issue:1-2 Topics: Amygdala; Animals; Blood Pressure; Consciousness; Guanabenz; Hypertension; Kidney; Male; Propanolamines; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Stress, Physiological; Sympathetic Nervous System; Yohimbine	1987
[Clinical and fundamental study of guanabenz in hypertensive patients with renal failure]. Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:6 Topics: Adult; Aged; Female; Guanabenz; Guanidines; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis	1988
Sinoatrial and atrioventricular dysfunction associated with the use of guanabenz acetate. The Canadian journal of cardiology, 1988, Volume: 4, Issue:3 Topics: Aged; Aged, 80 and over; Bradycardia; Cardiac Pacing, Artificial; Female; Guanabenz; Guanidines; Heart Block; Heart Conduction System; Humans; Hypertension; Sinoatrial Block	1988
Effects of guanabenz on sodium and water homeostasis. Journal of clinical hypertension, 1987, Volume: 3, Issue:4 Topics: Adult; Blood Pressure; Creatinine; Guanabenz; Guanidines; Humans; Hypertension; Kidney Concentrating Ability; Male; Middle Aged; Sodium, Dietary; Water-Electrolyte Balance	1987
Safety and efficacy of guanabenz in hypertensive patients with moderate renal insufficiency. Journal of clinical hypertension, 1985, Volume: 1, Issue:4 Topics: Blood Urea Nitrogen; Body Weight; Creatinine; Female; Guanabenz; Guanidines; Humans; Hypertension; Kidney Diseases; Male; Middle Aged	1985
Treatment of hypertension in the elderly. Southern medical journal, 1986, Volume: 79, Issue:3 Topics: Aged; Blood Pressure; Drug Evaluation; Drug Therapy, Combination; Guanabenz; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Retrospective Studies; Systole	1986