Page last updated: 2024-10-28

guaifenesin and Rhinitis, Allergic, Nonseasonal

guaifenesin has been researched along with Rhinitis, Allergic, Nonseasonal in 43 studies

Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.

Research Excerpts

ExcerptRelevanceReference
"Twenty-two non-allergic and 18 allergic patients with nasal polyps were administered clarithromycin 500 mg/day (single oral dose) for eight weeks."5.16Effect of long-term, low-dose clarithromycin on T helper 2 cytokines, eosinophilic cationic protein and the 'regulated on activation, normal T cell expressed and secreted' chemokine in the nasal secretions of patients with nasal polyposis. ( Matković-Jožin, S; Perić, A; Vojvodić, D, 2012)
"Nasal mucociliary clearance was measured using a saccharin technique in 172 patients with perennial rhinitis (76 also had asthma) and in 121 patients with chronic infected rhinosinusitis (40 had asthma, 35 had bronchiectasis)."3.67Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease. ( Cole, PJ; Greenstone, MA; Mackay, IS; Stanley, PJ; Wilson, R, 1985)
"Gross epistaxis is apparent as a red lavage fluid, while microepistaxis may yield a clear fluid."1.31Nasal lavage concentrations of free hemoglobin as a marker of microepistaxis during nasal provocation testing. ( Baraniuk, JN; Clauw, D; Naranch, K; Park, YJ; Repka-Ramirez, MS; Velarde, A, 2002)
"Type I allergy is thought to be involved in the sinusitis which is called allergic sinusitis."1.30[Clinical features and characteristics of paranasal sinus effusion in allergic sinusitis]. ( Mogi, G; Sakamoto, N; Suko, T; Suzuki, M, 1998)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199012 (27.91)18.7374
1990's10 (23.26)18.2507
2000's15 (34.88)29.6817
2010's6 (13.95)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Erffmeyer, JE1
McKenna, WR1
Lieberman, PL1
Yoo, TJ1
Taylor, WW1
Gröger, M1
Bernt, A1
Wolf, M1
Mack, B1
Pfrogner, E1
Becker, S1
Kramer, MF1
Pignatti, P1
Pala, G1
Pisati, M1
Perfetti, L1
Banchieri, G1
Moscato, G1
Cho, HJ1
Lee, HJ1
Kim, SC1
Kim, K1
Kim, YS1
Kim, CH1
Lee, JG1
Yoon, JH1
Choi, JY1
Gadzhimirzaev, GA1
Mikhrailova, ZT1
Akhmedov, IG1
Muradova, GR1
Perić, A1
Vojvodić, D1
Matković-Jožin, S1
Shah, SA1
Ishinaga, H1
Hou, B1
Okano, M1
Takeuchi, K2
Yang, SH1
Hong, CY1
Yu, CL1
Braun, H2
Buzina, W2
Freudenschuss, K2
Beham, A2
Stammberger, H2
Watanabe, K1
Misu, T1
Inoue, S1
Edamatsu, H1
Rogers, DF1
Lackner, A1
Shimizu, T2
Shimizu, S1
Hattori, R1
Mashima, Y1
Ishida, Y1
Nakamura, F1
Kanzato, H1
Sawada, D1
Hirata, H1
Nishimura, A1
Kajimoto, O1
Fujiwara, S1
Pant, H1
Kette, FE1
Smith, WB1
Wormald, PJ2
Macardle, PJ1
Dinh, QT1
Cryer, A1
Dinh, S1
Peiser, C1
Wu, S1
Springer, J1
Hamelmann, E1
Klapp, BF1
Heppt, W1
Fischer, A1
Ooi, EH1
Carney, AS1
James, CL1
Tan, LW1
Airaksinen, L1
Tuomi, T1
Vanhanen, M1
Voutilainen, R1
Toskala, E1
McCusker, CT1
Wang, Y1
Shan, J1
Kinyanjui, MW1
Villeneuve, A1
Michael, H1
Fixman, ED1
Berger, G1
Kogan, T1
Skutelsky, E1
Ophir, D1
Sasaki, Y1
Nakahara, H1
Hamaguchi, F1
Ukai, K2
Harada, I1
Sakakura, Y4
Asakura, K3
Enomoto, K1
Ara, H1
Azuma, E1
Kataura, A1
Häcki, M1
Brändli, O1
Mikulewicz, W1
Okuda, M2
Miura, I1
Juji, F1
Takashima, H1
Hattori, M1
Majima, Y3
Yoshimi, R1
Shinogi, J1
Harada, T1
Yuta, A1
Doyle, WJ1
Gaumond, E1
Ali, M1
Tamarkin, L1
Baraniuk, JN2
Van Deusen, M1
Cohen, S1
Skoner, DP1
Suzuki, M1
Suko, T1
Sakamoto, N1
Mogi, G1
Jean, R1
Rufin, P1
Pfister, A1
Landais, P1
Waernessyckle, S1
de Blic, J1
Scheinmann, P1
Ohkubo, K1
Ikeda, M1
Pawankar, R1
Gotoh, M1
Yagi, T1
Hirano, H1
Park, YJ1
Repka-Ramirez, MS1
Naranch, K1
Velarde, A1
Clauw, D1
Sato, Y1
Kojima, T2
Tanaka, K1
Okamoto, Y1
Nagaya, Y1
Nishimura, F1
Takeoka, A1
Hanada, S1
Kohno, S1
Kawai, M1
Armengot, M1
Marco, J1
Kohno, H1
Seyama, Y1
Yamashita, S1
Aramaki, H1
Inoue, H1
Yamada, T1
Yamada, K1
Ishikawa, T1
Stanley, PJ1
Wilson, R1
Greenstone, MA1
Mackay, IS1
Cole, PJ1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Health Promotion on Allergic Rhinitis by Infrared-C Ray Irradiation[NCT03673384]50 participants (Actual)Interventional2015-03-02Completed
Effect of Traditional Chinese Medicine on Gut Microbiota, Physical Constitution, and Allergic Diseases[NCT03033290]Phase 360 participants (Anticipated)Interventional2018-01-10Recruiting
Phase 3 Study of Qi-tonifying Chinese Herbal Products for Treatment of Allergic Rhinitis[NCT01631032]Phase 3112 participants (Actual)Interventional2012-07-31Completed
A Randomized, Double-blind, Placebo-controlled Trial of Lactobacillus Acidophilus L92 on Markers of Allergic Inflammation by Nasal Provocation With Grass Pollen[NCT00554736]Phase 30 participants (Actual)Interventional2006-05-31Withdrawn (stopped due to Sponsor suspended study do to funding)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for guaifenesin and Rhinitis, Allergic, Nonseasonal

ArticleYear
Airway hypersecretion in allergic rhinitis and asthma: new pharmacotherapy.
    Current allergy and asthma reports, 2003, Volume: 3, Issue:3

    Topics: Asthma; Capillary Permeability; Chloride Channels; Glucocorticoids; Histamine Antagonists; Humans; M

2003
[The role of eosinophil in nasal allergy].
    Nihon rinsho. Japanese journal of clinical medicine, 1993, Volume: 51, Issue:3

    Topics: Blood Proteins; Cell Degranulation; Eosinophil Granule Proteins; Eosinophil Peroxidase; Eosinophils;

1993

Trials

5 trials available for guaifenesin and Rhinitis, Allergic, Nonseasonal

ArticleYear
Efficacy of phenylephrine-phenylpropanolamine in the treatment of rhinitis.
    Southern medical journal, 1982, Volume: 75, Issue:5

    Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Guaifenesin;

1982
Effect of long-term, low-dose clarithromycin on T helper 2 cytokines, eosinophilic cationic protein and the 'regulated on activation, normal T cell expressed and secreted' chemokine in the nasal secretions of patients with nasal polyposis.
    The Journal of laryngology and otology, 2012, Volume: 126, Issue:5

    Topics: Adult; Aged; Anti-Bacterial Agents; Chemokine CCL5; Clarithromycin; Cytokines; Eosinophil Cationic P

2012
The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs.
    International immunopharmacology, 2002, Volume: 2, Issue:12

    Topics: Adolescent; Adult; Apoptosis; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 2; Dinopro

2002
The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs.
    International immunopharmacology, 2002, Volume: 2, Issue:12

    Topics: Adolescent; Adult; Apoptosis; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 2; Dinopro

2002
The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs.
    International immunopharmacology, 2002, Volume: 2, Issue:12

    Topics: Adolescent; Adult; Apoptosis; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 2; Dinopro

2002
The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs.
    International immunopharmacology, 2002, Volume: 2, Issue:12

    Topics: Adolescent; Adult; Apoptosis; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 2; Dinopro

2002
Clinical effects of Lactobacillus acidophilus strain L-92 on perennial allergic rhinitis: a double-blind, placebo-controlled study.
    Journal of dairy science, 2005, Volume: 88, Issue:2

    Topics: Animals; Double-Blind Method; Fermentation; Food Handling; Hot Temperature; Humans; Immunoglobulin E

2005
Symposium: The upper airways under attack.
    European journal of respiratory diseases. Supplement, 1983, Volume: 126

    Topics: Administration, Intranasal; Anti-Bacterial Agents; Cilia; Clinical Trials as Topic; Common Cold; Dru

1983

Other Studies

36 other studies available for guaifenesin and Rhinitis, Allergic, Nonseasonal

ArticleYear
Eosinophils and mast cells: a comparison of nasal mucosa histology and cytology to markers in nasal discharge in patients with chronic sino-nasal diseases.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2013, Volume: 270, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Chronic Disease; Eosin

2013
Nasal blown secretion evaluation in specific occupational nasal challenges.
    International archives of occupational and environmental health, 2010, Volume: 83, Issue:2

    Topics: Adolescent; Adult; Aged; Case-Control Studies; Eosinophilia; Eosinophils; Humans; Immunologic Tests;

2010
Protease-activated receptor 2-dependent fluid secretion from airway submucosal glands by house dust mite extract.
    The Journal of allergy and clinical immunology, 2012, Volume: 129, Issue:2

    Topics: Adolescent; Adult; Aged; Antigens, Dermatophagoides; Carbachol; Exocrine Glands; Female; Humans; Imm

2012
[The role of disturbances of lipid metabolism in pathogenesis of allergic rhinitis].
    Vestnik otorinolaringologii, 2011, Issue:5

    Topics: Adolescent; Adult; Drug Administration Routes; Drug Therapy, Combination; Female; Histamine H1 Antag

2011
Effects of interleukin-31 on MUC5AC gene expression in nasal allergic inflammation.
    Pharmacology, 2013, Volume: 91, Issue:3-4

    Topics: Cell Line; Cell Line, Tumor; Gene Expression Regulation; Humans; Interleukins; Mucin 5AC; Mucus; Nas

2013
'Eosinophilic fungal rhinosinusitis': a common disorder in Europe?
    The Laryngoscope, 2003, Volume: 113, Issue:2

    Topics: Chronic Disease; Eosinophilia; Eosinophils; Fungi; Humans; Mucus; Mycoses; Nasal Cavity; Nasal Mucos

2003
Cytolysis of eosinophils in nasal secretions.
    The Annals of otology, rhinology, and laryngology, 2003, Volume: 112, Issue:2

    Topics: Cell Death; Cell Degranulation; Cell Membrane; Cell Movement; Eosinophil Peroxidase; Eosinophils; Hu

2003
[Incidence and detection of fungi and eosinophilic granulocytes in chronic rhinosinusitis].
    Laryngo- rhino- otologie, 2003, Volume: 82, Issue:5

    Topics: Chronic Disease; Colony Count, Microbial; Diagnosis, Differential; Eosinophilia; Eosinophils; Fungi;

2003
[Effect of azithromycin on mucus secretion from nasal epithelium].
    The Japanese journal of antibiotics, 2003, Volume: 56 Suppl A

    Topics: Animals; Anti-Bacterial Agents; Azithromycin; Cells, Cultured; Depression, Chemical; Disease Models,

2003
Fungal-specific humoral response in eosinophilic mucus chronic rhinosinusitis.
    The Laryngoscope, 2005, Volume: 115, Issue:4

    Topics: Adolescent; Adult; Aged; Alternaria; Antibodies, Fungal; Aspergillosis; Aspergillus fumigatus; Chron

2005
Transcriptional up-regulation of histamine receptor-1 in epithelial, mucus and inflammatory cells in perennial allergic rhinitis.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2005, Volume: 35, Issue:11

    Topics: Adolescent; Adult; Aged; Endothelial Cells; Epithelial Cells; Female; Humans; Male; Middle Aged; Muc

2005
Surfactant protein d expression in chronic rhinosinusitis patients and immune responses in vitro to Aspergillus and alternaria in a nasal explant model.
    The Laryngoscope, 2007, Volume: 117, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Allergens; Alternaria; Aspergillus fumigatus; Eosinophilia; Female;

2007
Use of nasal provocation test in the diagnostics of occupational rhinitis.
    Rhinology, 2007, Volume: 45, Issue:1

    Topics: Acaridae; Adult; Allergens; Animals; Dust; Epithelium; Female; Flour; Fungi; Humans; Irritants; Male

2007
Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT-6 peptide.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Aug-15, Volume: 179, Issue:4

    Topics: Acute Disease; Administration, Intranasal; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Mo

2007
Glycoconjugate expression in perennial allergic rhinitis: a lectin histopathological study.
    Acta oto-laryngologica, 2007, Volume: 127, Issue:10

    Topics: Adult; Biomarkers; Glycoconjugates; Humans; Lectins; Mucus; Nasal Mucosa; Rhinitis, Allergic, Perenn

2007
[Epithelial changes in the nasal mucosa of patients with allergic rhinitis].
    Josai Shika Daigaku kiyo. The Bulletin of the Josai Dental University, 1984, Volume: 13, Issue:2

    Topics: Basement Membrane; Epithelium; Humans; Microscopy, Electron; Mucus; Nasal Mucosa; Rhinitis, Allergic

1984
[Nasal mocosal hypersensitivity to histamine and acetylcholine and histamine content in nasal secretion on manifested and non-manifested nasal allergy].
    Nihon Jibiinkoka Gakkai kaiho, 1983, Jun-20, Volume: 86, Issue:6

    Topics: Acetylcholine; Adolescent; Child; Child, Preschool; Histamine; Humans; Mucus; Nasal Mucosa; Nasal Pr

1983
Nasal responsiveness to methacholine stimulation in allergic rhinitis patients.
    Archives of oto-rhino-laryngology, 1984, Volume: 239, Issue:3

    Topics: Administration, Topical; Humans; Methacholine Compounds; Mucus; Nasal Provocation Tests; Rhinitis, A

1984
[Eosinophil concentration in nasal secretion in bronchial asthma].
    Schweizerische medizinische Wochenschrift, 1981, Aug-15, Volume: 111, Issue:33

    Topics: Asthma; Diagnosis, Differential; Eosinophils; Humans; Leukocyte Count; Mucus; Nasal Mucosa; Rhinitis

1981
[The effect of the technique of mucosa secretion obtaining on the results of biochemical investigations (author's transl)].
    Otolaryngologia polska = The Polish otolaryngology, 1980, Volume: 34, Issue:2-3

    Topics: Adult; Female; Humans; Male; Mucus; Muramidase; Nasal Mucosa; Rhinitis, Allergic, Perennial; Specime

1980
A novel method of counting eosinophils in nasal secretion of allergic rhinitis by hemocytometric method.
    International archives of allergy and immunology, 1994, Volume: 104 Suppl 1, Issue:1

    Topics: Adult; Blood Cell Count; Eosinophilia; Eosinophils; Humans; Leukocyte Count; Mucins; Mucus; Nasal Mu

1994
Effects of nasal allergen challenge on dynamic viscoelasticity of nasal mucus.
    The Annals of otology, rhinology, and laryngology, 1993, Volume: 102, Issue:4 Pt 1

    Topics: Adolescent; Adult; Allergens; Child; Dust; Elasticity; Female; Humans; Male; Mucus; Nasal Provocatio

1993
Quantitative cytology of nasal secretions with perennial allergic rhinitis in children: comparison of noninfected and infected conditions.
    The Laryngoscope, 1998, Volume: 108, Issue:5

    Topics: Adolescent; Animals; Child; Child, Preschool; Eosinophils; Female; Humans; Leukocyte Count; Male; Mi

1998
Rhinovirus infection induces mucus hypersecretion.
    The American journal of physiology, 1998, Volume: 274, Issue:6

    Topics: Adolescent; Adult; Alcian Blue; Coloring Agents; Exocytosis; Glycoproteins; Humans; Immunoglobulin G

1998
[Clinical features and characteristics of paranasal sinus effusion in allergic sinusitis].
    Nihon Jibiinkoka Gakkai kaiho, 1998, Volume: 101, Issue:6

    Topics: Adolescent; Adult; Aged; Eosinophils; Female; Humans; Hypersensitivity; Interleukin-5; Leukocyte Cou

1998
Diagnostic value of nasal provocation challenge with allergens in children.
    Allergy, 1998, Volume: 53, Issue:10

    Topics: Adolescent; Allergens; Antigens, Dermatophagoides; Asthma; Cell Count; Child; Child, Preschool; Conj

1998
Mechanisms of IL-6, IL-8, and GM-CSF release in nasal secretions of allergic patients after nasal challenge.
    Rhinology, 1998, Volume: 36, Issue:4

    Topics: Animals; Enzyme-Linked Immunosorbent Assay; Granulocyte-Macrophage Colony-Stimulating Factor; Humans

1998
A mechanism of antigen-induced mucus production in nasal epithelium of sensitized rats. A comparison with lipopolysaccharide-induced mucus production.
    American journal of respiratory and critical care medicine, 2000, Volume: 161, Issue:5

    Topics: Animals; Antigens; Chlorpheniramine; Chromones; Cimetidine; Dexamethasone; Eosinophils; Histamine H1

2000
Nasal lavage concentrations of free hemoglobin as a marker of microepistaxis during nasal provocation testing.
    Allergy, 2002, Volume: 57, Issue:4

    Topics: Adult; Albumins; Anti-Inflammatory Agents; Biomarkers; Epistaxis; Erythrocytes; Female; Hemoglobins;

2002
Improved staining method of the mast cell, etc. in nasal secretion.
    Zeitschrift fur Erkrankungen der Atmungsorgane, 1979, Volume: 153, Issue:2

    Topics: Eosinophils; Humans; Mast Cells; Mucus; Nasal Mucosa; Neutrophils; Rhinitis, Allergic, Perennial; St

1979
[The study of chemical mediators in the patients with allergic rhinitis 2). Histamine, leukotriene and kinins in the nasal secretion during dual phase response].
    Nihon Jibiinkoka Gakkai kaiho, 1991, Volume: 94, Issue:3

    Topics: Adult; Female; Histamine; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Kinins; Le

1991
[The study of chemical mediators in the patients with allergic rhinitis. 1). Histamine, leukotriene and kinins in the nasal secretion during early phase response].
    Nihon Jibiinkoka Gakkai kaiho, 1990, Volume: 93, Issue:7

    Topics: Acute-Phase Reaction; Adolescent; Adult; Female; Histamine; Humans; Kinins; Male; Middle Aged; Mucus

1990
A nasal allergy model developed in the guinea pig by intranasal application of 2,4-toluene diisocyanate.
    International archives of allergy and applied immunology, 1988, Volume: 85, Issue:4

    Topics: Administration, Intranasal; Animals; Cyanates; Disease Models, Animal; Guinea Pigs; Histamine; Male;

1988
[Changes in nasal mucociliary clearance in normal subject and in patients with various nasal pathologies].
    Anales otorrinolaringologicos ibero-americanos, 1987, Volume: 14, Issue:2

    Topics: Adolescent; Adult; Aged; Cilia; Female; Humans; Male; Middle Aged; Mucus; Nasal Mucosa; Rhinitis; Rh

1987
[Effects of iodine-enriched egg (IE-egg) on nasal allergy: basic and clinical investigations].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1986, Volume: 88, Issue:3

    Topics: Alkaloids; Animals; Azo Compounds; Benzylisoquinolines; Eggs; Female; Food, Fortified; Glucuronidase

1986
Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease.
    British journal of diseases of the chest, 1985, Volume: 79, Issue:1

    Topics: Adolescent; Adult; Asthma; Bronchiectasis; Cilia; Female; Humans; Male; Middle Aged; Mucus; Nose; Rh

1985