guaifenesin has been researched along with Pulmonary Fibrosis in 32 studies
Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Montelukast, a leukotriene receptor antagonist, is used commercially as a maintenance treatment for asthma and to relieve allergic symptoms." | 7.79 | Effects of montelukast on subepithelial/peribronchial fibrosis in a murine model of ovalbumin induced chronic asthma. ( Jeon, WY; Lee, MY; Shin, HK; Shin, IS, 2013) |
| "treatment." | 3.83 | Pyunkang-hwan (Pyunkang-Tang) ameliorates air pollutant-induced inflammatory hypersecretion of airway mucus and bleomycin-\ induced pulmonary fibrosis in rats. ( Choong, JL; Hyo-Seok, S; Hyun, JL, 2016) |
| "Montelukast, a leukotriene receptor antagonist, is used commercially as a maintenance treatment for asthma and to relieve allergic symptoms." | 3.79 | Effects of montelukast on subepithelial/peribronchial fibrosis in a murine model of ovalbumin induced chronic asthma. ( Jeon, WY; Lee, MY; Shin, HK; Shin, IS, 2013) |
| "Asthma, chronic obstructive pulmonary disease, and cystic fibrosis are three chronic pulmonary diseases that affect an estimated 420 million individuals across the globe." | 2.58 | Epigenetics of Mucus Hypersecretion in Chronic Respiratory Diseases. ( Breitzig, MT; Kolliputi, N; Lockey, RF; Saco, TV, 2018) |
| "Chronic obstructive pulmonary disease (COPD) is characterized and defined by limitation of expiratory airflow." | 2.43 | Pathogenesis of COPD. ( Rennard, SI; Spurzem, JR, 2005) |
| "Interestingly, pulmonary fibrosis observed in wild-type mice under the chronic protocol was completely absent in iNOS(-/-) mice despite persistent IL-5 and IL-13 production, suggesting that these cytokines were insufficient for pulmonary fibrosis." | 1.36 | Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation. ( Abd Elmageed, ZY; Boulares, AH; Errami, Y; Hans, CP; Ju, J; Kim, H; Naura, AS; Ochoa, AC; Park, J; Rodriguez, PC; Zerfaoui, M, 2010) |
| " In the present study, we have investigated the effect of a therapeutic dosing regimen with an anti-IL-13 monoclonal antibody (mAb) in a chronic mouse model of persistent asthma." | 1.33 | Therapeutic dosing with anti-interleukin-13 monoclonal antibody inhibits asthma progression in mice. ( Bugelski, PJ; Das, AM; Emmell, E; Giles-Komar, J; Griswold, DE; Lakshminarayanan, M; Li, L; Petley, T; Rafferty, P; Volk, A; Yang, G, 2005) |
| "Five idiopathic pulmonary fibrosis (IPF) patients with sputum since the initial period of the disease (IPF SP+, more than 15 ml/day) were compared with five IPF patients without sputum throughout the course of the disease (IPF SP-) and four control subjects without pulmonary disease matched for age and sex." | 1.28 | Morphometric analysis of airways in idiopathic pulmonary fibrosis patients with mucous hypersecretion. ( Aikawa, T; Andoh, Y; Sasaki, H; Shimura, S; Takishima, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (34.38) | 18.7374 |
| 1990's | 3 (9.38) | 18.2507 |
| 2000's | 7 (21.88) | 29.6817 |
| 2010's | 11 (34.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HEISEN, AJ | 1 |
| Saco, TV | 1 |
| Breitzig, MT | 1 |
| Lockey, RF | 1 |
| Kolliputi, N | 1 |
| Hyo-Seok, S | 1 |
| Hyun, JL | 1 |
| Choong, JL | 1 |
| Shin, IS | 1 |
| Jeon, WY | 1 |
| Shin, HK | 1 |
| Lee, MY | 1 |
| Pusterla, N | 1 |
| Magdesian, KG | 1 |
| Mapes, SM | 1 |
| Zavodovskaya, R | 1 |
| Kass, PH | 1 |
| Franchini, ML | 1 |
| Athanazio, R | 1 |
| Amato-Lourenço, LF | 1 |
| Carreirão-Neto, W | 1 |
| Saldiva, PH | 1 |
| Lorenzi-Filho, G | 1 |
| Rubin, BK | 1 |
| Nakagawa, NK | 1 |
| Chen, J | 1 |
| Yang, X | 1 |
| Zhang, W | 1 |
| Peng, D | 1 |
| Xia, Y | 1 |
| Lu, Y | 1 |
| Han, X | 1 |
| Song, G | 1 |
| Zhu, J | 1 |
| Liu, R | 1 |
| Alcorn, JF | 1 |
| van der Velden, J | 1 |
| Brown, AL | 1 |
| McElhinney, B | 1 |
| Irvin, CG | 1 |
| Janssen-Heininger, YM | 1 |
| Oh, SY | 1 |
| Zheng, T | 2 |
| Kim, YK | 1 |
| Cohn, L | 1 |
| Homer, RJ | 4 |
| McKenzie, AN | 1 |
| Zhu, Z | 3 |
| Ramaprakash, H | 1 |
| Hogaboam, CM | 1 |
| Halwani, R | 1 |
| Al-Muhsen, S | 1 |
| Al-Jahdali, H | 1 |
| Hamid, Q | 1 |
| Naura, AS | 1 |
| Zerfaoui, M | 1 |
| Kim, H | 1 |
| Abd Elmageed, ZY | 1 |
| Rodriguez, PC | 1 |
| Hans, CP | 1 |
| Ju, J | 1 |
| Errami, Y | 1 |
| Park, J | 1 |
| Ochoa, AC | 1 |
| Boulares, AH | 1 |
| van Echteld, CJ | 1 |
| Beckmann, N | 1 |
| Cho, JY | 1 |
| Pham, A | 1 |
| Rosenthal, P | 1 |
| Miller, M | 1 |
| Doherty, T | 1 |
| Broide, DH | 1 |
| POLGAR, G | 1 |
| DENTON, R | 1 |
| Yang, G | 1 |
| Li, L | 1 |
| Volk, A | 1 |
| Emmell, E | 1 |
| Petley, T | 1 |
| Giles-Komar, J | 1 |
| Rafferty, P | 1 |
| Lakshminarayanan, M | 1 |
| Griswold, DE | 1 |
| Bugelski, PJ | 1 |
| Das, AM | 1 |
| Spurzem, JR | 1 |
| Rennard, SI | 1 |
| Muz, MH | 1 |
| Deveci, F | 1 |
| Bulut, Y | 1 |
| Ilhan, N | 1 |
| Yekeler, H | 1 |
| Turgut, T | 1 |
| Chapoval, SP | 1 |
| Al-Garawi, A | 1 |
| Lora, JM | 1 |
| Strickland, I | 1 |
| Ma, B | 2 |
| Lee, PJ | 1 |
| Ghosh, S | 1 |
| Coyle, AJ | 1 |
| Elias, JA | 3 |
| Lewis, JF | 1 |
| Edwards, CW | 1 |
| Carlile, A | 1 |
| Cockrill, BA | 1 |
| Hales, CA | 1 |
| Wang, Z | 1 |
| Chen, Q | 1 |
| Geba, GP | 1 |
| Wang, J | 1 |
| Zhang, Y | 1 |
| Lee, CG | 1 |
| Charo, IF | 1 |
| Noble, P | 1 |
| Bouton, C | 1 |
| Herson, S | 1 |
| Huchon, G | 1 |
| Akoun, G | 1 |
| Andoh, Y | 1 |
| Aikawa, T | 1 |
| Shimura, S | 1 |
| Sasaki, H | 1 |
| Takishima, T | 1 |
| Isawa, T | 1 |
| Teshima, T | 1 |
| Hirano, T | 1 |
| Ebina, A | 1 |
| Konno, K | 1 |
| Gent, M | 1 |
| Knowlson, PA | 1 |
| Rime, FJ | 1 |
| Benda, R | 1 |
| Fuchsova, M | 1 |
| Hronovský, V | 1 |
| Dunnill, MS | 1 |
| Ryder, RC | 1 |
| Lyons, JP | 1 |
| Campbell, H | 1 |
| Gough, J | 1 |
| Ulmer, WT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy of the AIRVO Warm Humidifier as an Add on to Oxygen Therapy as Well as Stand-alone Therapy in Patients With Respiratory Insufficiency[NCT03081650] | 30 participants (Anticipated) | Interventional | 2016-08-16 | Recruiting | |||
| Effects of Long-term Dry and Humidified Low-flow Oxygen Via Nasal Cannula on Nasal Mucociliary Clearance, Mucus Properties, Inflammation and Airway Symptoms in Patients[NCT02515786] | Phase 1/Phase 2 | 19 participants (Anticipated) | Interventional | 2013-01-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for guaifenesin and Pulmonary Fibrosis
| Article | Year |
|---|---|
Epigenetics of Mucus Hypersecretion in Chronic Respiratory Diseases.
Topics: Asthma; Cystic Fibrosis; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Histone C | 2018 |
Role of transforming growth factor-β in airway remodeling in asthma.
Topics: Airway Remodeling; Animals; Asthma; Eosinophils; Goblet Cells; Humans; Inflammation Mediators; Lung; | 2011 |
A view on imaging in drug research and development for respiratory diseases.
Topics: Animals; Clinical Trials as Topic; Diagnostic Imaging; Disease Models, Animal; Drug Delivery Systems | 2011 |
Pathogenesis of COPD.
Topics: Airway Resistance; Apoptosis; Cytokines; Environmental Pollutants; Female; Humans; Male; Mucus; Prog | 2005 |
Allergic bronchopulmonary aspergillosis.
Topics: Administration, Oral; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Asthma; Bronc | 1999 |
[Bronchiolo-alveolar cancer].
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adolescent; Adult; Bronchi; Female; Humans; Lung; Lung Neoplasm | 1976 |
2 trials available for guaifenesin and Pulmonary Fibrosis
| Article | Year |
|---|---|
Oxygen With Cold Bubble Humidification Is No Better Than Dry Oxygen in Preventing Mucus Dehydration, Decreased Mucociliary Clearance, and Decline in Pulmonary Function.
Topics: Aged; Aged, 80 and over; Bronchiectasis; Cough; Cytokines; Disease Progression; Epidermal Growth Fac | 2016 |
Oxygen With Cold Bubble Humidification Is No Better Than Dry Oxygen in Preventing Mucus Dehydration, Decreased Mucociliary Clearance, and Decline in Pulmonary Function.
Topics: Aged; Aged, 80 and over; Bronchiectasis; Cough; Cytokines; Disease Progression; Epidermal Growth Fac | 2016 |
Oxygen With Cold Bubble Humidification Is No Better Than Dry Oxygen in Preventing Mucus Dehydration, Decreased Mucociliary Clearance, and Decline in Pulmonary Function.
Topics: Aged; Aged, 80 and over; Bronchiectasis; Cough; Cytokines; Disease Progression; Epidermal Growth Fac | 2016 |
Oxygen With Cold Bubble Humidification Is No Better Than Dry Oxygen in Preventing Mucus Dehydration, Decreased Mucociliary Clearance, and Decline in Pulmonary Function.
Topics: Aged; Aged, 80 and over; Bronchiectasis; Cough; Cytokines; Disease Progression; Epidermal Growth Fac | 2016 |
Effect of bromhexine on ventilatory capacity in patients with a variety of chest diseases.
Topics: Adult; Airway Resistance; Aniline Compounds; Asthma; Chronic Disease; Clinical Trials as Topic; Fema | 1969 |
24 other studies available for guaifenesin and Pulmonary Fibrosis
| Article | Year |
|---|---|
TREATMENT OF BRONCHIAL AND PULMONARY PARENCHYMAL DISORDERS.
Topics: Asthma; Bronchitis; Geriatrics; Guaifenesin; Humans; Lung Diseases; Pulmonary Emphysema; Pulmonary F | 1964 |
Pyunkang-hwan (Pyunkang-Tang) ameliorates air pollutant-induced inflammatory hypersecretion of airway mucus and bleomycin-\
induced pulmonary fibrosis in rats.
Topics: Air Pollutants; Animals; Bleomycin; Collagen; Drugs, Chinese Herbal; Humans; Hydroxyproline; Lung; M | 2016 |
Effects of montelukast on subepithelial/peribronchial fibrosis in a murine model of ovalbumin induced chronic asthma.
Topics: Acetates; Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cycloprop | 2013 |
Assessment of quantitative polymerase chain reaction for equine herpesvirus-5 in blood, nasal secretions and bronchoalveolar lavage fluid for the laboratory diagnosis of equine multinodular pulmonary fibrosis.
Topics: Animals; Bronchoalveolar Lavage Fluid; Herpesviridae Infections; Horse Diseases; Horses; Mucus; Poly | 2017 |
Therapeutic Effects of Resveratrol in a Mouse Model of LPS and Cigarette Smoke-Induced COPD.
Topics: Animals; Beclin-1; Bronchoalveolar Lavage Fluid; Cytokines; Lipopolysaccharides; Lung; Mice; Mucus; | 2016 |
c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis.
Topics: Animals; Antigens; Bleomycin; Collagen; Enzyme Activation; Epithelium; Gene Expression Regulation; I | 2009 |
A critical role of SHP-1 in regulation of type 2 inflammation in the lung.
Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Epithelium; Hypertrophy | 2009 |
Intranasal CpG therapy attenuated experimental fungal asthma in a TLR9-dependent and -independent manner.
Topics: Adjuvants, Immunologic; Administration, Intranasal; Animals; Aspergillus fumigatus; Asthma; Bronchia | 2010 |
Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation.
Topics: Acute Disease; Allergens; Animals; Cells, Cultured; Chickens; Eosinophilia; Gene Deletion; Inflammat | 2010 |
Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling.
Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchi; Collagen; Eosinophils; Extracellular Matrix | 2011 |
Cystic fibrosis in adults. Studies of pulmonary function and some physical properties of bronchial mucus.
Topics: Adult; Cystic Fibrosis; Humans; Lung; Mucus; Pulmonary Fibrosis; Respiration | 1962 |
Therapeutic dosing with anti-interleukin-13 monoclonal antibody inhibits asthma progression in mice.
Topics: Animals; Antibodies, Monoclonal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Ch | 2005 |
The effects of low dose leukotriene receptor antagonist therapy on airway remodeling and cysteinyl leukotriene expression in a mouse asthma model.
Topics: Acetates; Airway Obstruction; Animals; Anti-Asthmatic Agents; Asthma; Collagen; Cyclopropanes; Cyste | 2006 |
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.
Topics: Adenoviridae; Animals; Apoptosis; Caspases; Heterocyclic Compounds, 3-Ring; I-kappa B Kinase; Inflam | 2007 |
Fatal bronchial asthma in children: report of three cases.
Topics: Asthma; Bronchi; Child, Preschool; Death; Female; Humans; Male; Mucus; Pulmonary Emphysema; Pulmonar | 1967 |
The larger bronchi in cryptogenic fibrosing alveolitis: a morphometric study.
Topics: Adult; Aged; Bronchi; Bronchitis; Exocrine Glands; Female; Humans; Hypertrophy; Male; Middle Aged; M | 1982 |
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.
Topics: Airway Resistance; Animals; Asthma; Bronchi; Bronchoconstrictor Agents; Chemokine CCL11; Chemokines, | 1999 |
IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemokine CCL2; Chemokines, CC; Endopeptidas | 2002 |
Morphometric analysis of airways in idiopathic pulmonary fibrosis patients with mucous hypersecretion.
Topics: Aged; Bronchi; Eosinophils; Exocrine Glands; Female; Humans; Lung; Lymphocytes; Macrophages; Male; M | 1992 |
Mucociliary clearance mechanism in interstitial lung disease.
Topics: Aerosols; Cilia; Humans; Lung; Methods; Mucus; Pulmonary Fibrosis; Radionuclide Imaging; Sarcoidosis | 1986 |
Course of air-borne infection cause by B virus (Herpesvirus simiae) II. Distribution of B virus in the organism of rabbits and histopathological changes in the organs.
Topics: Adrenal Glands; Aerosols; Animals; Blood; Central Nervous System; Heart; Herpesviridae Infections; I | 1969 |
The contribution of morphology to the study of chronic obstructive lung disease.
Topics: Adult; Age Factors; Aged; Airway Obstruction; Biopsy; Bronchi; Bronchitis; Cilia; Exudates and Trans | 1974 |
Bronchial mucous gland status in coal workers' pneumoconiosis.
Topics: Age Factors; Aged; Autopsy; Bronchi; Coal Mining; Humans; Lung; Male; Middle Aged; Mucus; Pneumoconi | 1972 |
Emphysema of the lung: clinical and experimental investigations of its pathogenesis.
Topics: Humans; Mucus; Pleura; Pressure; Pulmonary Emphysema; Pulmonary Fibrosis; Radiography; Respiration; | 1970 |