Page last updated: 2024-10-28

guaifenesin and Otitis Media with Effusion

guaifenesin has been researched along with Otitis Media with Effusion in 31 studies

Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.

Otitis Media with Effusion: Inflammation of the middle ear with a clear pale yellow-colored transudate.

Research Excerpts

ExcerptRelevanceReference
"Interleukin-8 (IL-8), a potent neutrophilic chemoattractant and inflammatory cytokine, is present in middle ear effusions (MEEs) of children with otitis media and is thought to be responsible for the accumulation of neutrophils in MEEs."7.69Interleukin-8 concentration predicts the neutrophil count in middle ear effusion. ( Izzo, AA; Nassif, PS; Nicklaus, PJ; Simpson, SQ, 1997)
"Interleukin-8 (IL-8), a potent neutrophilic chemoattractant and inflammatory cytokine, is present in middle ear effusions (MEEs) of children with otitis media and is thought to be responsible for the accumulation of neutrophils in MEEs."3.69Interleukin-8 concentration predicts the neutrophil count in middle ear effusion. ( Izzo, AA; Nassif, PS; Nicklaus, PJ; Simpson, SQ, 1997)
"Chronic sinusitis is often the result of bacterial infections that lead to chronic inflammation with thickening of the sinus mucosa and hypersecretion of mucus."2.42Clinical implications of the immunomodulatory effects of macrolides on sinusitis. ( Majima, Y, 2004)
"Ectodermal dysplasia is a rare group of diseases presenting special problems in management for the otolaryngologist, but the full spectrum of otorhinolaryngologic manifestations has been previously unrecognized in the otolaryngologic literature."2.38Ectodermal dysplasia: the otolaryngologic manifestations and management. ( Potsic, WP; Siegel, MB, 1990)
"Middle ear effusion was obtained from children with otitis media with effusion and separated into thick (mucoid) and thin (serous) pools."2.37Mucolytic agents and otitis media with effusion. ( Birchall, JP; Fitzgerald, JE; Green, GG; Pearson, JP, 1988)
"serous middle ear effusions (MEEs)."1.48Characterization of mucoid and serous middle ear effusions from patients with chronic otitis media: implication of different biological mechanisms? ( Anna, K; Brown, K; Gordish-Dressman, H; Nino, G; Pérez-Losada, M; Poley, M; Preciado, D; Val, S, 2018)
"Seventeen mucoid middle ear effusions were collected from the tympanic cavity of 15 cats 1 or 2 weeks after tubal obstruction."1.28Rheological properties of middle ear mucus in relation to goblet cell population in cat. ( Hamaguchi, Y; Jin, CS; Juhn, SK; Majima, Y; Sakakura, Y; Takeuchi, K, 1991)
"Sixteen of 28 middle ear effusions demonstrated significant amounts of MMS."1.28Macrophage (monocyte)-derived mucous secretagougue (MMS) is released into the fluid of the middle ear of patients with otitis media with effusion. ( Bernstein, JM; Goswami, S; Marom, Z, 1990)
"The properties of pooled thick and thin middle ear effusions, from children with otitis media with effusion, were studied by viscometry."1.28Rheologic studies on middle ear effusions and their mucus glycoproteins. ( Birchall, JP; FitzGerald, JE; Green, GG; Pearson, JP, 1989)
"Middle ear effusion was obtained from children with chronic secretory otitis media undergoing myringotomy."1.27Characterization of human middle ear mucus glycoprotein in chronic secretory otitis media (CSOM). ( Birchall, JP; FitzGerald, JE; Green, GG; Pearson, JP; Stafford, FW, 1987)
"Although the treatment of chronic middle ear effusion in children by paracentesis and the insertion of a ventilator tube is popular, it is well recognized that this method does not always provide a cure."1.26Middle ear effusions: a consideration of factors involved in their aetiology, maintenance and treatment. ( Smyth, GD, 1978)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199012 (38.71)18.7374
1990's11 (35.48)18.2507
2000's7 (22.58)29.6817
2010's1 (3.23)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Val, S1
Poley, M1
Anna, K1
Nino, G1
Brown, K1
Pérez-Losada, M1
Gordish-Dressman, H1
Preciado, D1
Malaty, J1
Antonelli, PJ3
Westine, JG2
Giannoni, CM2
Gajewski, B1
Majima, Y3
Sanabria, J1
Márquez, F1
Gutiérrez, R1
Cenjor, C1
Wong, J1
Hawke, M1
Van Cauwenberge, P1
Giebink, GS2
Le, CT1
Paparella, MM2
Berger, G1
Nassif, PS1
Simpson, SQ1
Izzo, AA1
Nicklaus, PJ1
Lin, J1
Vambutas, A1
Haruta, A1
Kim, Y1
Pospiech, L1
Jaworska, M1
Kubacka, M1
Chung, MH1
Choi, JY1
Lee, WS1
Kim, HN1
Yoon, JH1
Smyth, GD1
Gamble, JE1
Bizal, JA1
Daetwyler, EP1
Palva, T2
Taskinen, E1
Lehtinen, T2
Ramsay, H1
Björksten, F1
Hackman, P1
Jin, CS2
Takeuchi, K2
Hamaguchi, Y2
Sakakura, Y2
Juhn, SK2
Luntz, M1
Levit, I1
Sadé, J1
Bernstein, JM1
Goswami, S1
Marom, Z1
Siegel, MB1
Potsic, WP2
Elwany, S1
Marriott, C1
FitzGerald, JE3
Green, GG3
Birchall, JP3
Pearson, JP3
Basterra, J1
Carbonell, R1
Armengot, M1
Matoses, S1
Stafford, FW1
Halmepuro, L1
Marsh, RR1
Baranak, CC1

Reviews

4 reviews available for guaifenesin and Otitis Media with Effusion

ArticleYear
Clinical implications of the immunomodulatory effects of macrolides on sinusitis.
    The American journal of medicine, 2004, Nov-08, Volume: 117 Suppl 9A

    Topics: Anti-Bacterial Agents; Chronic Disease; Humans; Immunologic Factors; Macrolides; Mucus; Nasal Polyps

2004
Mucus physiopathology, update and new therapeutic tendencies.
    Revue de laryngologie - otologie - rhinologie, 2004, Volume: 125, Issue:4

    Topics: Drug Therapy; Humans; Mucus; Otitis Media with Effusion; Sinusitis

2004
Ectodermal dysplasia: the otolaryngologic manifestations and management.
    International journal of pediatric otorhinolaryngology, 1990, Volume: 19, Issue:3

    Topics: Acute Disease; Ectodermal Dysplasia; Humans; Infant; Male; Mucus; Nasal Obstruction; Nose Diseases;

1990
Mucolytic agents and otitis media with effusion.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1988, Volume: 42, Issue:8

    Topics: Amino Acids; Child; Child, Preschool; Expectorants; Glycoproteins; Humans; In Vitro Techniques; Infa

1988

Trials

1 trial available for guaifenesin and Otitis Media with Effusion

ArticleYear
Symposium: The upper airways under attack.
    European journal of respiratory diseases. Supplement, 1983, Volume: 126

    Topics: Administration, Intranasal; Anti-Bacterial Agents; Cilia; Clinical Trials as Topic; Common Cold; Dru

1983

Other Studies

26 other studies available for guaifenesin and Otitis Media with Effusion

ArticleYear
Characterization of mucoid and serous middle ear effusions from patients with chronic otitis media: implication of different biological mechanisms?
    Pediatric research, 2018, Volume: 84, Issue:2

    Topics: Blood Proteins; Child; Child, Preschool; Chronic Disease; Complement System Proteins; DNA, Bacterial

2018
Effect of blood and mucus on tympanostomy tube biofilm formation.
    The Laryngoscope, 2008, Volume: 118, Issue:5

    Topics: Bacteriology; Biofilms; Blood Proteins; Cerebrospinal Fluid Otorrhea; Fibronectins; Humans; In Vitro

2008
Defining tympanostomy tube plugs.
    The Laryngoscope, 2002, Volume: 112, Issue:6

    Topics: Amino Acids; Chromatography, High Pressure Liquid; Humans; Middle Ear Ventilation; Monosaccharides;

2002
Opening plugged tympanostomy tubes.
    The Laryngoscope, 2002, Volume: 112, Issue:8 Pt 1

    Topics: Equipment Design; Middle Ear Ventilation; Mucus; Otitis Media with Effusion; Postoperative Complicat

2002
The cytopathology of middle ear effusions (a new technique).
    The Journal of otolaryngology, 1983, Volume: 12, Issue:6

    Topics: Blood Cell Count; Cell Separation; Ear, Middle; Exudates and Transudates; Humans; Microscopy, Electr

1983
Otitis media with effusion. Functional morphology and physiopathology of the structures involved.
    Acta oto-rhino-laryngologica Belgica, 1982, Volume: 36, Issue:1

    Topics: Adolescent; Adult; Aged; Animals; Bacterial Infections; Child; Child, Preschool; Dogs; Ear, Middle;

1982
Epidemiology of otitis media with effusion in children.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1982, Volume: 108, Issue:9

    Topics: Child; Child, Preschool; Humans; Infant; Mucus; Otitis Media; Otitis Media with Effusion; Otitis Med

1982
Eustachian tube submucosal glands in normal and pathological temporal bones.
    The Journal of laryngology and otology, 1993, Volume: 107, Issue:12

    Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Chronic Disease; Eusta

1993
Interleukin-8 concentration predicts the neutrophil count in middle ear effusion.
    The Laryngoscope, 1997, Volume: 107, Issue:9

    Topics: Adolescent; Analysis of Variance; Cell Count; Chemotaxis, Leukocyte; Child; Child, Preschool; Enzyme

1997
Pneumococcus activation of the 5-lipoxygenase pathway and production of glycoproteins in the middle ear of rats.
    The Journal of infectious diseases, 1999, Volume: 179, Issue:5

    Topics: Animals; Arachidonate 5-Lipoxygenase; Ear, Middle; Enzyme Activation; Gene Expression; Glycoproteins

1999
Soluble L-selectin and interleukin-8 in otitis media with effusion.
    Auris, nasus, larynx, 2000, Volume: 27, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Drainage; Female; Humans; Infant; Interleukin-8; L-Selectin; Ma

2000
Compositional difference in middle ear effusion: mucous versus serous.
    The Laryngoscope, 2002, Volume: 112, Issue:1

    Topics: Child; Child, Preschool; Ear, Middle; Female; Humans; Immunoglobulin A, Secretory; Interleukin-8; Ma

2002
Middle ear effusions: a consideration of factors involved in their aetiology, maintenance and treatment.
    Clinical otolaryngology and allied sciences, 1978, Volume: 3, Issue:4

    Topics: Air; Bacterial Infections; Cholesteatoma; Cilia; Ear Diseases; Ear, Middle; Eustachian Tube; Humans;

1978
Otitis media and chronic middle ear effusion in the asthmatic pediatric patient.
    Ear, nose, & throat journal, 1992, Volume: 71, Issue:9

    Topics: Adolescent; Asthma; Child; Child, Preschool; Chronic Disease; Ear, Middle; Humans; Infant; Middle Ea

1992
Mast cells and histamine in adenoid tissue and middle ear.
    Acta oto-laryngologica, 1991, Volume: 111, Issue:2

    Topics: Adenoids; Chronic Disease; Ear, Middle; Epithelium; Histamine; Humans; Mast Cells; Mucous Membrane;

1991
Rheological properties of middle ear mucus in relation to goblet cell population in cat.
    Acta oto-laryngologica. Supplementum, 1991, Volume: 483

    Topics: Animals; Cats; Cell Count; Ear, Middle; Elasticity; Models, Biological; Mucous Membrane; Mucus; Otit

1991
Effects of endotoxin and neutrophil lysate on experimental otitis media with effusion in cats.
    Acta oto-laryngologica. Supplementum, 1991, Volume: 483

    Topics: Animals; Cats; Cytological Techniques; Ear, Middle; Elasticity; Endotoxins; Epithelial Cells; Escher

1991
The histological patterns of normal and inflamed middle ear mucosa.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 1991, Volume: 248, Issue:3

    Topics: Child, Preschool; Exocrine Glands; Humans; Infant; Infant, Newborn; Inflammation; Mucus; Otitis Medi

1991
Macrophage (monocyte)-derived mucous secretagougue (MMS) is released into the fluid of the middle ear of patients with otitis media with effusion.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1990, Volume: 103, Issue:1

    Topics: Adolescent; Cells, Cultured; Child; Child, Preschool; Ear, Middle; Glycoproteins; Humans; Infant; Mi

1990
Tympanic neurectomy: its effects on the seromucinous glands of the middle ear of cats.
    ORL; journal for oto-rhino-laryngology and its related specialties, 1990, Volume: 52, Issue:5

    Topics: Animals; Cats; Ear, Middle; Exocrine Glands; Microscopy, Electron; Middle Ear Ventilation; Mucous Me

1990
Mucolytic agents for glue ear.
    Lancet (London, England), 1985, Nov-09, Volume: 2, Issue:8463

    Topics: Acetylcysteine; Administration, Oral; Carbocysteine; Child; Cysteine; Humans; In Vitro Techniques; M

1985
Rheologic studies on middle ear effusions and their mucus glycoproteins.
    Archives of otolaryngology--head & neck surgery, 1989, Volume: 115, Issue:4

    Topics: Acetylcysteine; Carbocysteine; Child; Glycoproteins; Humans; In Vitro Techniques; Mercaptoethanol; M

1989
[Immunologic study of the nasal mucus and secretion in chronic otitis media with closed tympanum].
    Anales otorrinolaringologicos ibero-americanos, 1988, Volume: 15, Issue:6

    Topics: Chronic Disease; Ear, Middle; Humans; Immunoglobulins; Mucus; Nasal Mucosa; Otitis Media with Effusi

1988
Characterization of human middle ear mucus glycoprotein in chronic secretory otitis media (CSOM).
    Clinica chimica acta; international journal of clinical chemistry, 1987, Nov-16, Volume: 169, Issue:2-3

    Topics: Child; Child, Preschool; Ear, Middle; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Humans; In

1987
Immunoglobulin E in mucoid secretory otitis media.
    ORL; journal for oto-rhino-laryngology and its related specialties, 1985, Volume: 47, Issue:4

    Topics: Child; Child, Preschool; Chronic Disease; Humans; Immunoglobulin A; Immunoglobulin E; Immunoglobulin

1985
Hearing loss and visco-elasticity of middle ear fluid.
    International journal of pediatric otorhinolaryngology, 1985, Volume: 9, Issue:2

    Topics: Animals; Cochlear Microphonic Potentials; Elasticity; Female; Guinea Pigs; Hearing Loss; Hearing Los

1985