guaifenesin has been researched along with Nasal Polyps in 53 studies
Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
Nasal Polyps: Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-two non-allergic and 18 allergic patients with nasal polyps were administered clarithromycin 500 mg/day (single oral dose) for eight weeks." | 5.16 | Effect of long-term, low-dose clarithromycin on T helper 2 cytokines, eosinophilic cationic protein and the 'regulated on activation, normal T cell expressed and secreted' chemokine in the nasal secretions of patients with nasal polyposis. ( Matković-Jožin, S; Perić, A; Vojvodić, D, 2012) |
| "NK may be an effective alternative therapeutic option in patients with CRSwNP and comorbid asthma by causing fibrin degradation." | 3.85 | Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus. ( Fujieda, S; Imoto, Y; Ishizuka, T; Kato, Y; Narita, N; Sakashita, M; Takabayashi, T; Tokunaga, T; Yoshida, K, 2017) |
| "Chronic sinusitis is often the result of bacterial infections that lead to chronic inflammation with thickening of the sinus mucosa and hypersecretion of mucus." | 2.42 | Clinical implications of the immunomodulatory effects of macrolides on sinusitis. ( Majima, Y, 2004) |
| "Herbal decoction and acupuncture treatment for nasal polyps are rarely seen in the current English literature." | 1.36 | Recurrent nasal polyps treated by Chinese herbal decoction and acupuncture: a case report. ( Miao, EY, 2010) |
| "A total of 248 patients with mucoviscidosis (cystic fibrosis, CF) were assessed by means of nasal endoscopy." | 1.30 | Chronic rhinosinusitis in cystic fibrosis (mucoviscidosis). ( Brihaye, P; Clement, PA; Jorissen, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (18.87) | 18.7374 |
| 1990's | 4 (7.55) | 18.2507 |
| 2000's | 10 (18.87) | 29.6817 |
| 2010's | 20 (37.74) | 24.3611 |
| 2020's | 9 (16.98) | 2.80 |
| Authors | Studies |
|---|---|
| Corey, KB | 1 |
| Turner, JH | 5 |
| Chowdhury, NI | 3 |
| Chandra, RK | 5 |
| Li, P | 5 |
| Wu, P | 1 |
| Cahill, KN | 1 |
| Parra-Ferro, M | 1 |
| Justice, JM | 1 |
| Lobo, BC | 1 |
| Munger, SD | 1 |
| Schlosser, RJ | 4 |
| Mulligan, JK | 4 |
| Liu, Z | 1 |
| Hong, J | 1 |
| Huang, X | 3 |
| Wu, D | 3 |
| Pesold, VV | 1 |
| Wendler, O | 2 |
| Morgenthaler, L | 1 |
| Gröhn, F | 1 |
| Mueller, SK | 3 |
| Nocera, A | 1 |
| Grundtner, P | 1 |
| Schlegel, P | 1 |
| Agaimy, A | 1 |
| Iro, H | 1 |
| Bleier, BS | 2 |
| Kao, SS | 1 |
| Bassiouni, A | 1 |
| Ramezanpour, M | 1 |
| Chegeni, N | 1 |
| Colella, AD | 1 |
| Chataway, TK | 1 |
| Wormald, PJ | 1 |
| Vreugde, S | 1 |
| Psaltis, AJ | 1 |
| Soler, ZM | 3 |
| Smith, TL | 3 |
| Mace, JC | 3 |
| Ramakrishan, VR | 1 |
| Norris-Caneda, K | 1 |
| Bethard, JR | 1 |
| Ball, LE | 1 |
| Mattos, JL | 1 |
| Ramakrishnan, VR | 2 |
| Beswick, DM | 1 |
| Alt, JA | 1 |
| Yan, B | 1 |
| Wang, Y | 1 |
| Wang, C | 1 |
| Zhang, L | 1 |
| Tu, Y | 1 |
| Liu, J | 2 |
| Li, T | 1 |
| Zhou, X | 1 |
| Tan, KS | 2 |
| Ong, HH | 2 |
| Sun, K | 1 |
| Ouyang, Y | 1 |
| Liang, X | 1 |
| Ong, YK | 2 |
| Thong, M | 1 |
| Shi, L | 2 |
| Wang, DY | 2 |
| Takabayashi, T | 1 |
| Imoto, Y | 1 |
| Sakashita, M | 1 |
| Kato, Y | 1 |
| Tokunaga, T | 1 |
| Yoshida, K | 1 |
| Narita, N | 1 |
| Ishizuka, T | 1 |
| Fujieda, S | 1 |
| Sokoya, M | 1 |
| Frank, DN | 1 |
| Rahkola, J | 1 |
| Getz, A | 1 |
| Kingdom, TT | 1 |
| Kofonow, JM | 1 |
| Nguyen, Q | 1 |
| Janoff, EN | 1 |
| Li, YY | 1 |
| Andiappan, AK | 1 |
| Yan, Y | 1 |
| Thong, KT | 1 |
| Yu, FG | 1 |
| Low, HB | 1 |
| Zhang, YL | 1 |
| Bonnet, K | 1 |
| Schlundt, DG | 1 |
| Nocera, AL | 1 |
| Dillon, ST | 1 |
| Libermann, TA | 1 |
| Morse, JC | 1 |
| Ely, KA | 1 |
| Shilts, MH | 1 |
| Wannemuehler, TJ | 1 |
| Huang, LC | 1 |
| Sheng, Q | 1 |
| Das, SR | 1 |
| Ely, K | 1 |
| Gröger, M | 1 |
| Bernt, A | 1 |
| Wolf, M | 1 |
| Mack, B | 1 |
| Pfrogner, E | 2 |
| Becker, S | 1 |
| Kramer, MF | 2 |
| de Borja Callejas, F | 1 |
| Martínez-Antón, A | 1 |
| Alobid, I | 1 |
| Fuentes, M | 1 |
| Cortijo, J | 1 |
| Picado, C | 1 |
| Roca-Ferrer, J | 1 |
| Mullol, J | 1 |
| Sansoni, ER | 1 |
| Sautter, NB | 1 |
| Yawn, JR | 1 |
| Lawrence, LA | 1 |
| Luo, Q | 2 |
| Zhu, H | 1 |
| Feng, K | 2 |
| Jing, X | 1 |
| Zhang, J | 2 |
| Liu, D | 1 |
| Jin, X | 1 |
| Biswas, K | 1 |
| Chang, A | 1 |
| Hoggard, M | 1 |
| Radcliff, FJ | 1 |
| Jiang, Y | 1 |
| Taylor, MW | 1 |
| Darveau, R | 1 |
| Douglas, RG | 1 |
| Al Badaai, Y | 1 |
| DiFalco, MR | 1 |
| Tewfik, MA | 1 |
| Samaha, M | 1 |
| Miao, EY | 1 |
| Schmid, C | 1 |
| Habermann, W | 1 |
| Braun, H | 1 |
| Gugatschka, M | 1 |
| Oriel, BS | 1 |
| Smietana, JA | 1 |
| Stammberger, H | 1 |
| Lai, SK | 1 |
| Suk, JS | 1 |
| Pace, A | 1 |
| Wang, YY | 1 |
| Yang, M | 1 |
| Mert, O | 1 |
| Chen, J | 1 |
| Kim, J | 1 |
| Hanes, J | 1 |
| Perić, A | 1 |
| Vojvodić, D | 1 |
| Matković-Jožin, S | 1 |
| Jain, R | 1 |
| Stow, N | 1 |
| Douglas, R | 1 |
| Seong, JK | 1 |
| Koo, JS | 1 |
| Lee, WJ | 1 |
| Kim, HN | 1 |
| Park, JY | 1 |
| Song, KS | 1 |
| Hong, JH | 1 |
| Yoon, JH | 1 |
| Advenier, D | 1 |
| Guichard, Ch | 1 |
| Kémény, JL | 1 |
| Tridon, A | 1 |
| Gilain, L | 1 |
| Hauber, HP | 1 |
| Manoukian, JJ | 1 |
| Nguyen, LH | 1 |
| Sobol, SE | 1 |
| Levitt, RC | 1 |
| Holroyd, KJ | 1 |
| McElvaney, NG | 1 |
| Griffin, S | 1 |
| Hamid, Q | 1 |
| Majima, Y | 1 |
| Bernstein, JM | 1 |
| Kansal, R | 1 |
| Riechelmann, H | 1 |
| Deutschle, T | 1 |
| Rozsasi, A | 1 |
| Keck, T | 1 |
| Polzehl, D | 1 |
| Bürner, H | 1 |
| Eichner, H | 1 |
| Frates, RC | 1 |
| Kaizu, TT | 1 |
| Last, JA | 1 |
| Benali, R | 1 |
| Tournier, JM | 1 |
| Chevillard, M | 1 |
| Zahm, JM | 1 |
| Klossek, JM | 1 |
| Hinnrasky, J | 1 |
| Gaillard, D | 1 |
| Maquart, FX | 1 |
| Puchelle, E | 1 |
| Brihaye, P | 1 |
| Jorissen, M | 1 |
| Clement, PA | 1 |
| Forer, M | 1 |
| Ananda, S | 1 |
| Usui, S | 1 |
| Shimizu, T | 1 |
| Kishioka, C | 1 |
| Fujita, K | 1 |
| Sakakura, Y | 1 |
| Ostertag, P | 1 |
| Rasp, G | 1 |
| Nadel, JA | 1 |
| Oppenheimer, EH | 1 |
| Rosenstein, BJ | 1 |
| Tos, M | 3 |
| Mogensen, C | 1 |
| Larsen, PL | 2 |
| Møller, K | 1 |
| Yue, WL | 1 |
| Hiraide, F | 1 |
| Kakoi, H | 1 |
| Paisner, HM | 1 |
| Morony, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Moving Towards PREcision Medicine In United Airways Disease: Unraveling inflaMmatory Patterns in Asthmatic Patients With or Without Nasal Polyps (PREMIUM) - a Descriptive Pilot Study[NCT05009758] | 30 participants (Anticipated) | Interventional | 2021-09-01 | Recruiting | |||
| Effect of Health Promotion on Allergic Rhinitis by Infrared-C Ray Irradiation[NCT03673384] | 50 participants (Actual) | Interventional | 2015-03-02 | Completed | |||
| Determinants of Medical and Surgical Treatment Outcomes in Chronic Sinusitis[NCT01332136] | 966 participants (Actual) | Observational | 2011-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for guaifenesin and Nasal Polyps
| Article | Year |
|---|---|
Utilization of Nasal Mucus to Investigate the Pathophysiology of Chronic Rhinosinusitis.
Topics: Biomarkers; Chronic Disease; Cytokines; Humans; Mucus; Nasal Polyps; Rhinitis; Sinusitis | 2022 |
Analysis of CRSsNP Proteome Using a Highly Multiplexed Approach in Nasal Mucus.
Topics: Biomarkers; Calcium-Binding Proteins; Chronic Disease; Humans; Mucus; Nasal Polyps; Proteome; Proteo | 2023 |
Scoping review of chronic rhinosinusitis proteomics.
Topics: Chronic Disease; Humans; Mucus; Nasal Mucosa; Nasal Polyps; Proteomics; Rhinitis; Sinusitis | 2020 |
Clinical implications of the immunomodulatory effects of macrolides on sinusitis.
Topics: Anti-Bacterial Agents; Chronic Disease; Humans; Immunologic Factors; Macrolides; Mucus; Nasal Polyps | 2004 |
The management of postnasal drip.
Topics: Adult; Child; Child, Preschool; Chronic Disease; Humans; Mucociliary Clearance; Mucus; Nasal Mucosa; | 1999 |
Role of epidermal growth factor receptor activation in regulating mucin synthesis.
Topics: Animals; Asthma; Cell Differentiation; Cell Division; Epithelial Cells; ErbB Receptors; Goblet Cells | 2001 |
4 trials available for guaifenesin and Nasal Polyps
| Article | Year |
|---|---|
Prognostic and pharmacologic value of cystatin SN for chronic rhinosinusitis with nasal polyps.
Topics: Adult; Biomarkers; Chronic Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mucus; Nas | 2021 |
Vitamin D3 as a novel regulator of basic fibroblast growth factor in chronic rhinosinusitis with nasal polyposis.
Topics: Chemokine CCL2; Chemokine CCL5; Cholecalciferol; Chronic Disease; Endoscopy; Female; Fibroblast Grow | 2015 |
Released intranasal eosinophilic major basic protein as a diagnostic marker for polypoid chronic rhinosinusitis.
Topics: Adolescent; Adult; Aged; Biomarkers; Chronic Disease; Cohort Studies; Diagnosis, Differential; Eosin | 2010 |
Effect of long-term, low-dose clarithromycin on T helper 2 cytokines, eosinophilic cationic protein and the 'regulated on activation, normal T cell expressed and secreted' chemokine in the nasal secretions of patients with nasal polyposis.
Topics: Adult; Aged; Anti-Bacterial Agents; Chemokine CCL5; Clarithromycin; Cytokines; Eosinophil Cationic P | 2012 |
43 other studies available for guaifenesin and Nasal Polyps
| Article | Year |
|---|---|
Utility of nasal mucus inflammatory profile as a biomarker of nasal polyp regrowth in aspirin-exacerbated respiratory disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma, Aspirin-Induced; Biomarkers; Humans; Mucus | 2022 |
Olfactory cleft mucus galectin-10 predicts olfactory loss in chronic rhinosinusitis.
Topics: Chronic Disease; Galectins; Humans; Mucus; Nasal Polyps; Olfaction Disorders; Rhinitis; Sinusitis; S | 2023 |
Escalation in mucus cystatin 2, pappalysin-A, and periostin levels over time predict need for recurrent surgery in chronic rhinosinusitis with nasal polyps.
Topics: Adult; Cell Adhesion Molecules; Chronic Disease; Disease Progression; Female; Humans; Male; Middle A | 2019 |
Olfactory cleft mucus proteome in chronic rhinosinusitis: a case-control pilot study.
Topics: Case-Control Studies; Chronic Disease; Humans; Mucus; Nasal Polyps; Pilot Projects; Proteome; Rhinit | 2021 |
Olfactory cleft mucus inflammatory proteins in CRS: a case-control study.
Topics: Case-Control Studies; Chronic Disease; Cross-Sectional Studies; Humans; Mucus; Nasal Polyps; Rhiniti | 2021 |
Mucus composition abnormalities in sinonasal mucosa of chronic rhinosinusitis with and without nasal polyps.
Topics: Adult; Cells, Cultured; Chronic Disease; Female; Humans; Male; Middle Aged; Mucus; Nasal Mucosa; Nas | 2021 |
Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus.
Topics: Adult; Aged; Animals; Asthma; Chronic Disease; Disease Models, Animal; Eosinophils; Female; Fibrin; | 2017 |
Expression of immunoglobulin D is increased in chronic rhinosinusitis.
Topics: Adult; Biomarkers; Case-Control Studies; Chronic Disease; Female; Gene Expression; Humans; Immunoglo | 2017 |
Role of IL-13Rα2 in modulating IL-13-induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa.
Topics: Adolescent; Adult; Cells, Cultured; Dexamethasone; Female; Flavonoids; Glucocorticoids; Humans; Infl | 2018 |
Identification of clinically relevant chronic rhinosinusitis endotypes using cluster analysis of mucus cytokines.
Topics: Adult; Chronic Disease; Cytokines; Female; Humans; Inflammation; Male; Middle Aged; Mucus; Nasal Pol | 2018 |
Mucus T helper 2 biomarkers predict chronic rhinosinusitis disease severity and prior surgical intervention.
Topics: Biomarkers; Chronic Disease; Female; Humans; Interleukin-13; Interleukin-5; Male; Middle Aged; Mucus | 2018 |
Highly multiplexed proteomic analysis reveals significant tissue and exosomal coagulation pathway derangement in chronic rhinosinusitis with nasal polyps.
Topics: Adult; Blood Coagulation; Blood Coagulation Disorders; Chronic Disease; Exosomes; Female; Fibrinogen | 2018 |
Chronic rhinosinusitis in elderly patients is associated with an exaggerated neutrophilic proinflammatory response to pathogenic bacteria.
Topics: Adult; Aged; Bacteria; Bacterial Infections; Chronic Disease; Cluster Analysis; Cytokines; Female; H | 2019 |
Investigating the correlation between mucus cytokine levels, inflammatory cell counts, and baseline quality-of-life measures in chronic rhinosinusitis.
Topics: Adult; Aged; Chronic Disease; Cytokines; Endoscopy; Female; Humans; Leukocyte Count; Male; Middle Ag | 2019 |
Eosinophils and mast cells: a comparison of nasal mucosa histology and cytology to markers in nasal discharge in patients with chronic sino-nasal diseases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Chronic Disease; Eosin | 2013 |
Reconstituted human upper airway epithelium as 3-d in vitro model for nasal polyposis.
Topics: Cells, Cultured; Chemokines; Epithelial Cells; Humans; Immunohistochemistry; In Vitro Techniques; La | 2014 |
[Expression of hypoxia inducible factor-1α in chronic rhinosinusitis and the relationship with mucin secretion].
Topics: Chronic Disease; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mucins; Mu | 2015 |
[Expression and relationship of pendrin and MUC5AC in patients with chronic rhinosinusitis].
Topics: Chronic Disease; Epithelial Cells; Humans; Immunohistochemistry; Mucin 5AC; Mucus; Nasal Mucosa; Nas | 2015 |
Toll-like receptor activation by sino-nasal mucus in chronic rhinosinusitis.
Topics: Adult; Aged; Aged, 80 and over; Cystic Fibrosis; Cytokines; Female; Humans; Male; Middle Aged; Mucus | 2017 |
Quantitative proteomics of nasal mucus in chronic sinusitis with nasal polyposis.
Topics: Adult; Chromatography, Liquid; Chronic Disease; Electrophoresis, Polyacrylamide Gel; Female; Humans; | 2009 |
Recurrent nasal polyps treated by Chinese herbal decoction and acupuncture: a case report.
Topics: Acupuncture Therapy; Anti-Infective Agents; Combined Modality Therapy; Drugs, Chinese Herbal; Humans | 2010 |
Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus.
Topics: Drug Carriers; Humans; In Vitro Techniques; Mucus; Nanoparticles; Nasal Polyps; Poloxamer; Polyethyl | 2011 |
Comparison of anatomical abnormalities in patients with limited and diffuse chronic rhinosinusitis.
Topics: Adult; Case-Control Studies; Chronic Disease; Female; Humans; Male; Middle Aged; Mucus; Nasal Cavity | 2013 |
Upregulation of MUC8 and downregulation of MUC5AC by inflammatory mediators in human nasal polyps and cultured nasal epithelium.
Topics: Cells, Cultured; Chronic Disease; Humans; Mucin 5AC; Mucins; Mucus; Nasal Mucosa; Nasal Polyps; Reve | 2002 |
[Analysis of eosinophilia and ECP levels in blood and nasal secretions of 119 nasal polyposis patients].
Topics: Adult; Blood Proteins; Eosinophil Granule Proteins; Eosinophilia; Female; Humans; Male; Middle Aged; | 2002 |
Increased expression of interleukin-9, interleukin-9 receptor, and the calcium-activated chloride channel hCLCA1 in the upper airways of patients with cystic fibrosis.
Topics: Biopsy; Chloride Channels; Cystic Fibrosis; Epithelial Cells; Humans; Immunoenzyme Techniques; Inter | 2003 |
Superantigen hypothesis for the early development of chronic hyperplastic sinusitis with massive nasal polyposis.
Topics: Bacterial Toxins; Chronic Disease; Enterotoxins; Eosinophilia; Humans; Hyperplasia; Lymphocytes; Muc | 2005 |
Nasal biomarker profiles in acute and chronic rhinosinusitis.
Topics: Acute Disease; Adult; Biomarkers; Case-Control Studies; Chemokine CCL4; Chronic Disease; Female; Gra | 2005 |
Present possibilities for diagnosis in human nasal secretions.
Topics: Electrophoresis, Disc; Humans; Immunoglobulin A, Secretory; Immunoglobulin E; Mucus; Nasal Mucosa; N | 1983 |
Mucus glycoproteins secreted by respiratory epithelial tissue from cystic fibrosis patients.
Topics: Bronchi; Cystic Fibrosis; Epithelium; Glycoproteins; Humans; Mucus; Nasal Mucosa; Nasal Polyps; Resp | 1983 |
Tubule formation by human surface respiratory epithelial cells cultured in a three-dimensional collagen lattice.
Topics: Basement Membrane; Cell Division; Cell Separation; Cells, Cultured; Cilia; Collagen; Collagenases; C | 1993 |
Chronic rhinosinusitis in cystic fibrosis (mucoviscidosis).
Topics: Administration, Intranasal; Adolescent; Adult; Anti-Bacterial Agents; Child; Child, Preschool; Chron | 1997 |
Secretory cell differentiation and mucus secretion in cultures of human nasal epithelial cells: use of a monoclonal antibody to study human nasal mucin.
Topics: Antibodies, Monoclonal; Cell Culture Techniques; Cell Differentiation; Cilia; Enzyme-Linked Immunoso | 2000 |
Nasal interleukin-5, immunoglobulin E, eosinophilic cationic protein, and soluble intercellular adhesion molecule-1 in chronic sinusitis, allergic rhinitis, and nasal polyposis.
Topics: Adult; Aged; Blood Proteins; Chronic Disease; Enzyme-Linked Immunosorbent Assay; Eosinophil Granule | 2000 |
Differential pathology of nasal polyps in cystic fibrosis and atopy.
Topics: Adolescent; Adult; Basement Membrane; Child; Child, Preschool; Cystic Fibrosis; Exocrine Glands; Fem | 1979 |
Pathogenesis of nasal polyps.
Topics: Adult; Child; Edema; Epithelium; Exocrine Glands; Granulation Tissue; Humans; Mucus; Nasal Mucosa; N | 1977 |
Goblet cell density in nasal polyps.
Topics: Basement Membrane; Cell Count; Epithelium; Humans; Hyperplasia; Mucus; Nasal Mucosa; Nasal Polyps; S | 1990 |
Clinical significance of atrial natriuretic peptide in different diseases of the nose.
Topics: Adolescent; Adult; Atrial Natriuretic Factor; Female; Humans; Hypersensitivity; Male; Middle Aged; M | 1989 |
Nasal polyps: epithelium and goblet cell density.
Topics: Cell Count; Epithelium; Exocrine Glands; Humans; Mucus; Nasal Polyps | 1989 |
Histochemical study on innervation of glands and blood vessels in nasal polyps.
Topics: Acetylcholinesterase; Adrenergic Fibers; Arteries; Autonomic Nervous System; Catecholamines; Choline | 1986 |
Nasal obstruction.
Topics: Adenoids; Airway Obstruction; Ephedrine; Foreign Bodies; Hematoma; Histamine H1 Antagonists; Humans; | 1972 |
Nasal polyps.
Topics: Humans; Mucus; Nasal Mucosa; Nasal Polyps | 1973 |
Cystic fibrosis.
Topics: Abdomen, Acute; Aerosols; Anti-Bacterial Agents; Breathing Exercises; Cough; Cystic Fibrosis; Draina | 1970 |