guaifenesin and Muscle Contraction studies

Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.

Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Research Excerpts

Excerpt	Relevance	Reference
" The concentration-response curves for rate of mucus output, labelled-glycoprotein output and smooth muscle contraction in response to methacholine, phenylephrine and salbutamol were determined in the ferret trachea in vitro."	3.67	Comparison of mucus flow rate, radiolabelled glycoprotein output and smooth muscle contraction in the ferret trachea in vitro. ( Kyle, H; Widdicombe, JG; Wilffert, B, 1988)
"The effect of vasoactive intestinal peptide (VIP) was examined on the smooth muscle contraction and mucus secretion produced by methacholine and phenylephrine in the ferret whole trachea in vitro."	3.67	The effect of vasoactive intestinal peptide on smooth muscle tone and mucus secretion from the ferret trachea. ( Webber, SE; Widdicombe, JG, 1987)
"Lubiprostone is a chloride channel activator in clinical use for the treatment of chronic constipation, but the mechanisms of action of the drug are poorly understood."	1.38	Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility. ( Ameen, NA; Collaco, AM; Jakab, RL, 2012)
"Based on time from onset of symptoms to death, cases fell into two distinct groups: short course <3 (1."	1.33	Time to death, airway wall inflammation and remodelling in fatal asthma. ( Abramson, MJ; Elliot, JG; James, AL; Walters, EH, 2005)
"Few patients with anorectal foreign bodies will freely admit to transanal introduction."	1.30	Management of anorectal foreign bodies: a cause of obscure anal pain. ( Eu, KW; Ho, YH; Leong, A; Nyam, D; Ooi, BS; Seow-Choen, F, 1998)
" The slopes of the dose-response curves for DMPP + LTC4 did not differ by a statistically significant amount."	1.27	Leukotriene C4 and dimethylphenylpiperazinium-induced responses in canine airway tracheal muscle contraction and fluid secretion. ( Johnson, HG; Johnson, MA; McNee, ML; Miller, MD, 1983)
" Cholinergic agents (methacholine and acetylcholine) as well as 40-150 mM K+ showed a dose-response relationship and induced tension up to 12 mg."	1.27	Contractility of isolated single submucosal gland from trachea. ( Sasaki, H; Sasaki, T; Shimura, S; Takishima, T, 1986)

Timeframe	Studies, this research(%)	All Research%
pre-1990	25 (51.02)	18.7374
1990's	4 (8.16)	18.2507
2000's	16 (32.65)	29.6817
2010's	4 (8.16)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Hildebrand, SV	1
Hill, T	1
Beyhl, FE	1
Lindner, E	1
Usui, H	1
Osumi, S	1
Toda, N	1
Fujiwara, M	1
Lucetti, LT	1
Silva, RO	1
Santana, AP	1
de Melo Tavares, B	1
Vale, ML	1
Soares, PM	1
de Lima Júnior, FJ	1
Magalhães, PJ	1
de Queiroz Cunha, F	1
de Albuquerque Ribeiro, R	1
Medeiros, JR	1
Souza, MH	1
Sel, S	1
Rost, BR	1
Yildirim, AO	1
Sel, B	1
Kalwa, H	1
Fehrenbach, H	1
Renz, H	1
Gudermann, T	1
Dietrich, A	1
Jakab, RL	1
Collaco, AM	1
Ameen, NA	1
Akiba, Y	1
Kaunitz, JD	1
Aronsson, P	1
Johnsson, M	1
Vesela, R	1
Winder, M	1
Tobin, G	1
Hirsh, AJ	1
Sabater, JR	1
Zamurs, A	1
Smith, RT	1
Paradiso, AM	1
Hopkins, S	1
Abraham, WM	1
Boucher, RC	1
James, AL	1
Elliot, JG	1
Abramson, MJ	1
Walters, EH	1
Mead, J	2
Ford, LE	1
Brooks, GA	1
Fredberg, JJ	1
Seow, CY	1
Mitzner, W	1
DuBois, AB	1
Ameredes, BT	1
Panettiere, RA	1
Irvin, C	1
Permutt, S	1
Reel, KR	1
Fuhrman, FA	1
Casale, TB	1
Marom, Z	1
Johnson, HG	1
McNee, ML	1
Johnson, MA	1
Miller, MD	1
Zanjanian, MH	1
Davis, B	2
Roberts, AM	2
Coleridge, HM	2
Coleridge, JC	2
Ramnarine, SI	1
Hirayama, Y	1
Barnes, PJ	2
Rogers, DF	1
Ooi, BS	1
Ho, YH	1
Eu, KW	1
Nyam, D	1
Leong, A	1
Seow-Choen, F	1
Fahy, JV	1
Corry, DB	1
Boushey, HA	1
Skoglund, CR	1
Sjöberg, E	1
Chand, N	1
Stainken, DM	1
Piacentini, GL	1
Kaliner, MA	1
Löfdahl, CG	1
Tomioka, H	1
Webber, SE	2
Widdicombe, JG	3
Nadel, JA	1
Borson, DB	1
Sheppard, D	1
Kyle, H	1
Wilffert, B	1
Shimura, S	1
Sasaki, T	1
Sasaki, H	1
Takishima, T	1
Cooper, JA	1
Buck, MG	1
Gee, JB	1
Remacle, P	1
Bruart, J	1
Henneghien, C	1
Li, YF	1
Moody, FG	1
Weisbrodt, NW	1
Zalewsky, CA	1
Coelho, JC	1
Senninger, N	1
Gouma, D	1
Schultz, HD	1
Bratcher, C	1
Laurenzi, GA	1
Yin, S	1
Dolovich, J	1
Back, N	1
Arbesman, CE	1
Wardell, JR	1
Chakrin, LW	1
Payne, BJ	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Complications in the Management and Removal of Rectal and Vaginal Foreign Bodies[NCT05888363]				78 participants (Actual)	Observational	2020-12-08	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Expectorants and antitussive agents: are they helpful? Annals of allergy, 1980, Volume: 44, Issue:5 Topics: Airway Obstruction; Antitussive Agents; Bronchi; Cough; Expectorants; Humans; Immunoglobulin A; Immu	1980
Airway inflammation and remodeling in asthma. Current opinion in pulmonary medicine, 2000, Volume: 6, Issue:1 Topics: Airway Obstruction; Asthma; Basement Membrane; Bronchi; Bronchial Hyperreactivity; Bronchitis; Const	2000
FPL 55712 -- an antagonist of slow reacting substance of anaphylaxis (SRS-A): a review. Agents and actions, 1979, Volume: 9, Issue:2 Topics: Airway Resistance; Anaphylaxis; Animals; Blood Vessels; Chromones; Ethers; Hemodynamics; Humans; Hyp	1979
The potential roles of leukotrienes in bronchial asthma. The American review of respiratory disease, 1991, Volume: 143, Issue:5 Pt 2 Topics: Airway Obstruction; Asthma; Edema; Humans; Hypersensitivity, Immediate; Leukotriene Antagonists; Leu	1991
Calcium, calcium channel blockade and airways function. Acta pharmacologica et toxicologica, 1986, Volume: 58 Suppl 2 Topics: Adrenergic beta-Agonists; Allergens; Angina Pectoris; Animals; Asthma; Bronchi; Calcium; Calcium Cha	1986
[Bronchial asthma and prostaglandin related substances]. Nihon rinsho. Japanese journal of clinical medicine, 1985, Volume: 43, Issue:3 Topics: Animals; Arachidonic Acids; Asthma; Bronchi; Capillary Permeability; Guinea Pigs; Humans; In Vitro T	1985
Physiology of the parasympathetic nervous system of the lung. Postgraduate medical journal, 1987, Volume: 63 Suppl 1 Topics: Bronchi; Humans; Lung; Mucus; Muscle Contraction; Parasympathetic Nervous System; Pulmonary Ventilat	1987
Vegetable dust and airway disease: inflammatory mechanisms. Environmental health perspectives, 1986, Volume: 66 Topics: Animals; Antibody Formation; Blood Platelets; Byssinosis; Complement System Proteins; Dust; Edible G	1986

Article	Year
Neuromuscular blockade by use of atracurium in anesthetized llamas. American journal of veterinary research, 1993, Volume: 54, Issue:3 Topics: Analysis of Variance; Anesthesia, General; Animals; Atracurium; Blood Pressure; Camelids, New World;	1993
Diphasic action of the aliphatic amide, HOE 17879, on hepatic microsomal drug metabolizing enzymes in the mouse. Experientia, 1976, Mar-15, Volume: 32, Issue:3 Topics: Amides; Animals; Biphenyl Compounds; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome	1976
[Cardiovascular effects of guaiacol glycerol ether mononicotinate]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:6 Topics: Amobarbital; Anesthesia, General; Animals; Blood Pressure; Cardiovascular System; Dogs; Electrocardi	1972
Nitric Oxide and Hydrogen Sulfide Interact When Modulating Gastric Physiological Functions in Rodents. Digestive diseases and sciences, 2017, Volume: 62, Issue:1 Topics: Alkynes; Animals; Central Nervous System Depressants; Cystathionine gamma-Lyase; Drug Interactions;	2017
Loss of classical transient receptor potential 6 channel reduces allergic airway response. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2008, Volume: 38, Issue:9 Topics: Animals; Bronchial Hyperreactivity; Cells, Cultured; Epithelial Cells; Guinea Pigs; Hypersensitivity	2008
Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility. Digestive diseases and sciences, 2012, Volume: 57, Issue:11 Topics: Alprostadil; Analysis of Variance; Animals; Antiporters; Biopsy; CLC-2 Chloride Channels; Cyclic AMP	2012
May the truth be with you: lubiprostone as EP receptor agonist/ClC-2 internalizing "inhibitor". Digestive diseases and sciences, 2012, Volume: 57, Issue:11 Topics: Alprostadil; Animals; Exocytosis; Humans; Intestinal Mucosa; Lubiprostone; Mucus; Muscle Contraction	2012
Adenosine receptor antagonism suppresses functional and histological inflammatory changes in the rat urinary bladder. Autonomic neuroscience : basic & clinical, 2012, Nov-02, Volume: 171, Issue:1-2 Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Cyclophosphamide; Cystitis; Dose-Response Rel	2012
Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:3 Topics: Absorption; Amiloride; Animals; Bronchi; Cystic Fibrosis; Electrophysiology; Epithelial Cells; Epith	2004
Time to death, airway wall inflammation and remodelling in fatal asthma. The European respiratory journal, 2005, Volume: 26, Issue:3 Topics: Adolescent; Adult; Albuterol; Asthma; Bronchodilator Agents; Death; Female; Humans; Lung; Male; Mucu	2005
Point: airway smooth muscle is useful. Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:4 Topics: Animals; Humans; Lung; Models, Biological; Mucus; Muscle Contraction; Muscle, Smooth; Respiratory Me	2007
Comment on point:counterpoint: "airway smooth muscle is/is not useful". Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:6 Topics: Animals; Humans; Lung; Models, Biological; Mucus; Muscle Contraction; Muscle, Smooth; Respiratory Me	2007
Comments on point:counterpoint: "the lactate paradox does/does not occur during exercise at high altitude". Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:6 Topics: Animals; Humans; Lung; Models, Biological; Mucus; Muscle Contraction; Muscle, Smooth; Respiratory Me	2007
Counterpoint: airway smooth muscle is not useful. Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:4 Topics: Animals; Humans; Lung; Models, Biological; Mucus; Muscle Contraction; Muscle, Smooth; Respiratory Me	2007
Comments on point: counterpoint: "airway smooth muscle is/is not useful". Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:4 Topics: Animals; Humans; Lung; Models, Biological; Mucus; Muscle Contraction; Muscle, Smooth; Respiratory Me	2007
Comments on point: counterpoint: "airway smooth muscle is/is not useful". Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:4 Topics: Animals; Humans; Lung; Models, Biological; Mucus; Muscle Contraction; Muscle, Smooth; Respiratory Me	2007
Comments on point: counterpoint: "airway smooth muscle is/is not useful". Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:4 Topics: Animals; Humans; Lung; Models, Biological; Mucus; Muscle Contraction; Muscle, Smooth; Respiratory Me	2007
Comments on point: counterpoint: "airway smooth muscle is/is not useful". Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:4 Topics: Animals; Humans; Lung; Models, Biological; Mucus; Muscle Contraction; Muscle, Smooth; Respiratory Me	2007
Comments on point: counterpoint: "airway smooth muscle is/is not useful". Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:4 Topics: Animals; Humans; Lung; Models, Biological; Mucus; Muscle Contraction; Muscle, Smooth; Respiratory Me	2007
Comments on point: counterpoint: "airway smooth muscle is/is not useful". Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:4 Topics: Animals; Humans; Lung; Models, Biological; Mucus; Muscle Contraction; Muscle, Smooth; Respiratory Me	2007
Comments on point: counterpoint: "airway smooth muscle is/is not useful". Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:4 Topics: Animals; Humans; Lung; Models, Biological; Mucus; Muscle Contraction; Muscle, Smooth; Respiratory Me	2007
A further comment on point:counterpoint "airway smooth muscle is/is not useful". Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 103, Issue:1 Topics: Airway Resistance; Animals; Bronchi; Cough; Humans; Models, Biological; Mucus; Muscle Contraction; M	2007
An acetylcholine antagonist from the mucous secretion of the dorid nudibranch, Doriopsilla albopunctata. Comparative biochemistry and physiology. C: Comparative pharmacology, 1981, Volume: 68C, Issue:1 Topics: Acetylcholine; Animals; Chemical Phenomena; Chemistry; Guinea Pigs; In Vitro Techniques; Mollusca; M	1981
Mast cells and asthma. The role of mast cell mediators in the pathogenesis of allergic asthma. Annals of allergy, 1983, Volume: 51, Issue:1 Pt 1 Topics: Airway Obstruction; Asthma; Bradykinin; Capillary Permeability; Histamine; Humans; Leukotriene E4; M	1983
Leukotriene C4 and dimethylphenylpiperazinium-induced responses in canine airway tracheal muscle contraction and fluid secretion. International archives of allergy and applied immunology, 1983, Volume: 71, Issue:3 Topics: Animals; Dimethylphenylpiperazinium Iodide; Dogs; Dose-Response Relationship, Drug; Mucus; Muscle Co	1983
Reflex tracheal gland secretion evoked by stimulation of bronchial C-fibers in dogs. Journal of applied physiology: respiratory, environmental and exercise physiology, 1982, Volume: 53, Issue:4 Topics: Animals; Bradykinin; Bronchi; Dogs; Exocrine Glands; Mucus; Muscle Contraction; Muscle, Smooth; Refl	1982
'Sensory-efferent' neural control of mucus secretion: characterization using tachykinin receptor antagonists in ferret trachea in vitro. British journal of pharmacology, 1994, Volume: 113, Issue:4 Topics: Animals; Electric Stimulation; Ferrets; In Vitro Techniques; Male; Mucus; Muscle Contraction; Neurok	1994
Management of anorectal foreign bodies: a cause of obscure anal pain. The Australian and New Zealand journal of surgery, 1998, Volume: 68, Issue:12 Topics: Adolescent; Adult; Aged; Anal Canal; Anesthesia, General; Bronchopneumonia; Colon, Sigmoid; Consciou	1998
In vivo studies of individual mucous glands in the frog. Acta physiologica Scandinavica, 1977, Volume: 100, Issue:4 Topics: Animals; Anura; Electric Stimulation; Epithelial Cells; Epithelium; Exocrine Glands; Mucus; Muscle C	1977
The effect of a No. 2 fuel oil and a South Louisiana crude oil on the behavior of the soft shell clam, Mya arenaria L. Bulletin of environmental contamination and toxicology, 1976, Volume: 16, Issue:6 Topics: Animals; Behavior, Animal; Bivalvia; Fuel Oils; Hot Temperature; Lethal Dose 50; Mucus; Muscle Contr	1976
Action of a novel drug (Zy 16039) on mucus secretion in the ferret isolated trachea in vitro. Agents and actions, 1988, Volume: 24, Issue:1-2 Topics: Albumins; Animals; Benzopyrans; Dose-Response Relationship, Drug; Ferrets; In Vitro Techniques; Meth	1988
Modulation of tachykinins and bradykinin by enkephalinase. Progress in clinical and biological research, 1988, Volume: 263 Topics: Animals; Bradykinin; Ferrets; Humans; Metalloendopeptidases; Mucus; Muscle Contraction; Muscle, Smoo	1988
Comparison of mucus flow rate, radiolabelled glycoprotein output and smooth muscle contraction in the ferret trachea in vitro. British journal of pharmacology, 1988, Volume: 94, Issue:2 Topics: Albuterol; Animals; Female; Ferrets; Glycoproteins; In Vitro Techniques; Male; Methacholine Compound	1988
Contractility of isolated single submucosal gland from trachea. Journal of applied physiology (Bethesda, Md. : 1985), 1986, Volume: 60, Issue:4 Topics: Animals; Atropine; Cats; Dogs; Exocrine Glands; In Vitro Techniques; Methacholine Chloride; Methacho	1986
The effect of vasoactive intestinal peptide on smooth muscle tone and mucus secretion from the ferret trachea. British journal of pharmacology, 1987, Volume: 91, Issue:1 Topics: Animals; Female; Ferrets; In Vitro Techniques; Male; Methacholine Compounds; Mucus; Muramidase; Musc	1987
[Adrenergic receptors of the bronchoalveolar system in the obstructive syndrome]. Revue de pneumologie clinique, 1987, Volume: 43, Issue:2 Topics: Bronchi; Bronchial Spasm; Cilia; Humans; Lung Diseases, Obstructive; Mucus; Muscle Contraction; Pulm	1987
Gallbladder contractility and mucus secretion after cholesterol feeding in the prairie dog. Surgery, 1986, Volume: 100, Issue:5 Topics: Animals; Cholelithiasis; Cholesterol, Dietary; Gallbladder; Mucus; Muscle Contraction; Muscle, Smoot	1986
Pulmonary C-fibers reflexly increase secretion by tracheal submucosal glands in dogs. Journal of applied physiology (Bethesda, Md. : 1985), 1985, Volume: 58, Issue:3 Topics: Animals; Blood Pressure; Capsaicin; Cold Temperature; Dogs; Exocrine Glands; Heart Rate; Lung; Mucus	1985
Studies of mucus flow in the mammalian respiratory tract. I. The beneficial effects of acetyl ouabain on respiratory tract mucus flow. The American review of respiratory disease, 1971, Volume: 103, Issue:6 Topics: Animals; Calcium; Cats; Cilia; Digitalis Glycosides; Iodoacetates; Male; Mucus; Muscle Contraction;	1971
Kinin-like activity in nasal secretions of allergic patients. International archives of allergy and applied immunology, 1970, Volume: 38, Issue:4 Topics: Aerosols; Carboxypeptidases; Chymotrypsin; Dimercaprol; Endopeptidases; Humans; Kinins; Mucus; Muscl	1970
The canine tracheal pouch. A model for use in respiratory mucus research. The American review of respiratory disease, 1970, Volume: 101, Issue:5 Topics: Animals; Disease Models, Animal; Dogs; Methods; Models, Biological; Mucus; Muscle Contraction; Muscl	1970

guaifenesin and Muscle Contraction

Research Excerpts

Research

Studies (49)

Authors

Clinical Trials (1)

Trial Overview

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Other Studies