Compounds > guaifenesin
Page last updated: 2024-10-28

guaifenesin and Innate Inflammatory Response

guaifenesin has been researched along with Innate Inflammatory Response in 339 studies

Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.

Research Excerpts

ExcerptRelevanceReference
" azedarach fruit extract (MAE) using high-performance liquid chromatography (HPLC) and explored the therapeutic effects of MAE on pulmonary inflammation and mucus hypersecretion using a murine model of ovalbumin (OVA) exposed asthma."8.84Melia azedarach L. reduces pulmonary inflammation and mucus hypersecretion on a murine model of ovalbumin exposed asthma. ( Kim, T; Kim, WI; Lee, IS; Lee, SJ; Pak, SW; Shin, IS; Yang, YG, 2024)
"We demonstrated that intranasal adenosine administration effectively decreased inflammation and mucus production in a mouse model of viral ARS."8.31Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis. ( Ganama, M; Hua, X; Tilley, S; Varga, SM; Waldstein, KA, 2023)
"In this study, we investigated whether 4-hydroxycinnamic acid (HA) has a palliative effect on asthmatic inflammatory responses using a mouse model of ovalbumin (OVA)-induced allergic asthma."7.964-Hydroxycinnamic acid suppresses airway inflammation and mucus hypersecretion in allergic asthma induced by ovalbumin challenge. ( Choi, SJ; Kim, JC; Kim, MS; Kim, SH; Kim, YH; Ko, JW; Kwon, HJ; Seo, CS; Shin, IS; Shin, NR, 2020)
" argyi (TOTAL) and dehydromatricarin A (DA), its active component on ovalbumin (OVA)-induced allergic asthma."7.85Artemisia argyi attenuates airway inflammation in ovalbumin-induced asthmatic animals. ( Jeong, SH; Kim, HJ; Kim, JC; Ko, JW; Park, SH; Ryu, HW; Shin, IS; Shin, NR; Yuk, HJ, 2017)
"To observe the role of aminophylline and simvastatin in preventing and curing chronic obstructive pulmonary disease (COPD), and to explore the underlying mechanisms based on airway inflammation and mucus hypersecretion."7.83[Effect of aminophylline and simvastatin on airway inflammation and mucus hypersecretion in rats with chronic obstructive pulmonary disease]. ( Deng, X; Li, C; Ren, W; Wang, S; Xiong, L; Zhou, Q; Zhu, C, 2016)
"To explore the preventive and therapeutic effects of simvastatin on rats with chronic obstructive pulmonary disease (COPD) and examine the mechanism of airway inflammation and airway mucus hypersecretion."7.81[Effects of simvastatin on airway inflammation and airway mucus hypersecretion in rats with chronic obstructive pulmonary disease]. ( Deng, X; Li, C; Ren, W; Wang, S; Xiong, L; Zhou, Q; Zhu, C, 2015)
"Repeated inhalation of sevoflurane (SVF) can benefit asthmatic patients by bronchodilation."7.81Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation. ( Ding, PS; Fang, L; He, F; Liu, RY; Shen, QY; Wu, HM, 2015)
"To explore the impact of ozone on the airway hyperresponsinveness (AHR), airway inflammation and mucus production in an allergic asthma mouse model."7.81[Effects of ozone oxidative stress on the airway hyperresponsiveness and mucus production in mice with acute allergic airway inflammation]. ( Aihua, B; Feng, L; Xin, Z; Yuqing, C; Zhang, M, 2015)
"The flavonoid naringenin has been shown to attenuate airway inflammation and airway hyper‑reactivity in acute murine models of asthma."7.80Naringenin inhibits allergen‑induced airway remodeling in a murine model of asthma. ( Gu, W; Mao, S; Shi, Y; Tan, Y, 2014)
"We investigated the suitability of dendritic polyglycerol sulfates (dPGS), conjugated with a hydrophilic version of the indocyanine green label with 6 sulfonate groups (6S-ICG) to monitor sites of inflammation using an experimental mouse model of allergic asthma."7.79Dendritic polyglycerolsulfate near infrared fluorescent (NIRF) dye conjugate for non-invasively monitoring of inflammation in an allergic asthma mouse model. ( Alves, F; Biffi, S; Bosnjak, B; Dal Monego, S; Dullin, C; Epstein, MM; Garrovo, C; Licha, K; Welker, P, 2013)
" Female BALB/c mice sensitized and challenged with ovalbumin developed airway inflammation."7.78Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB. ( Cheng, C; Goh, FY; Guan, S; Leung, BP; Sethi, G; Shanmugam, MK; Upton, N; Wong, WS, 2012)
"Verapamil is a useful drug with therapeutic targeting on GCH and a potential way to limit mucous production and improve bronchial inflammation."7.78Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals. ( Ghafarzadegan, K; Hadi, R; Khakzad, MR; Meshkat, M; Mirsadraee, M; Mohammadpour, A; Saghari, M, 2012)
"The purposes of this study were to determine whether curcumin inhibits NF-κB-dependent transcription in vitro, and test whether treatment with curcumin reduces allergen-induced airway inflammation and hyper-responsiveness in a mouse model of asthma through inhibition of NF-κB pathway."7.77Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-κB inhibition. ( Cha, JY; Chang, BC; Jung, JE; Kim, DY; Kwon, HJ; Lee, BR; Oh, SW, 2011)
" Moreover, the thick colonic mucus layer obstructs the penetration of the drug, resulting in low bioavailability to the inflammatory site of the colon."5.72Mucus-Penetrating Alginate-Chitosan Nanoparticles Loaded with Berberine Hydrochloride for Oral Delivery to the Inflammation Site of Ulcerative Colitis. ( Chen, S; Fang, W; Gao, S; Hu, R; Lu, W; Nie, X; Sun, L; Zhang, Q, 2022)
"Formononetin has proven to be anti‑inflammatory and able to alleviate symptoms of certain allergic diseases."5.62Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells by activating the SIRT1/Nrf2 signaling pathway. ( Chen, X; Huang, J; Xie, A, 2021)
"H9N2 subtype avian influenza virus (H9N2 AIV) is a low pathogenic virus that is widely prevalent all over the world."5.56Effect of Baicalin on Bacterial Secondary Infection and Inflammation Caused by H9N2 AIV Infection in Chickens. ( Chen, L; Chen, S; Ci, X; Li, H; Lian, J; Lin, W; Lv, H; Xie, Q; Xie, Z; Ye, Y; Zhang, H; Zhang, X; Zhao, Q, 2020)
"Ulcers were induced by serosal application of 80 % acetic acid to the stomach of rats anaesthetized with 50 mg/kg thiopentone sodium and treatment was given three times daily."5.46Effects of quinine on gastric ulcer healing in Wistar rats. ( Adeniyi, OS; Friday, ET; Makinde, OV; Olaleye, SB, 2017)
"Formaldehyde (FA) is an environmental pollutant widely used in industry."5.42Short-term exposure to formaldehyde promotes oxidative damage and inflammation in the trachea and diaphragm muscle of adult rats. ( Bandeira, AC; Bezerra, FS; Lima, LF; Lima, WG; Murta, GL; Nardeli, CR, 2015)
"The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade."5.42Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. ( Ahn, KS; Hong, JM; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2015)
"Chronic mucosal inflammation is the hallmark of important and common airway diseases, such as allergic rhinitis (AR) and asthma."5.42Lipoxin B₄ promotes the resolution of allergic inflammation in the upper and lower airways of mice. ( Haworth, O; Karra, L; Levi-Schaffer, F; Levy, BD; Priluck, R, 2015)
"Melatonin was administered by intraperitoneal injection once per day at doses of 10 and 15 mg/kg from days 21 to 23 after the initial OVA sensitization."5.40Melatonin reduces airway inflammation in ovalbumin-induced asthma. ( Ahn, KS; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2014)
"Acute bronchiolitis was induced by inhalation of nickel chloride aerosols for 5 days in Wistar rats according to the method described by Kyono et al."5.31Inflammatory responses and mucus secretion in rats with acute bronchiolitis induced by nickel chloride. ( Ishihara, Y; Kawashima, H; Kyono, H; Miyasaka, M; Serita, F; Toya, T, 2002)
" azedarach fruit extract (MAE) using high-performance liquid chromatography (HPLC) and explored the therapeutic effects of MAE on pulmonary inflammation and mucus hypersecretion using a murine model of ovalbumin (OVA) exposed asthma."4.84Melia azedarach L. reduces pulmonary inflammation and mucus hypersecretion on a murine model of ovalbumin exposed asthma. ( Kim, T; Kim, WI; Lee, IS; Lee, SJ; Pak, SW; Shin, IS; Yang, YG, 2024)
"We demonstrated that intranasal adenosine administration effectively decreased inflammation and mucus production in a mouse model of viral ARS."4.31Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis. ( Ganama, M; Hua, X; Tilley, S; Varga, SM; Waldstein, KA, 2023)
"Ovalbumin (OVA) and cold water-induced cold asthma model were established in male mice."4.12Processed product (Pinelliae Rhizoma Praeparatum) of Pinellia ternata (Thunb.) Breit. Alleviates the allergic airway inflammation of cold phlegm via regulation of PKC/EGFR/MAPK/PI3K-AKT signaling pathway. ( Chen, S; Cheng, Y; Li, J; Liu, H; Tao, X; Wang, C; Wang, H; Wu, H; Xia, J; Xie, Y; Yu, H; Zeng, P; Zhang, P; Zhang, X, 2022)
"We established ovalbumin (OVA) induced asthmatic murine model and orally administrated Iristectorigenin A at concentration of 5 and 10 mg/kg and dexamethasone as a positive control substance."4.12Iristectorigenin A exerts novel protective properties against airway inflammation and mucus hypersecretion in OVA-induced asthmatic mice: Iristectorigenin A ameliorates asthma phenotype. ( Abduwaki, M; Cui, J; Dong, JC; Luo, Q; Lv, Y; Nabijan, M; Nurahmat, M; Qin, J; Tang, W; Teng, F; Wang, S; Wei, Y; Wuniqiemu, T; Zhou, Y; Zhu, X, 2022)
" An ovalbumin (OVA)-induced mouse asthma model was established and the effect of acupuncture on airway hyperresponsiveness (AHR), mucus hypersecretion and inflammation was assessed."4.02TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model. ( Cui, J; Dong, J; Dong, M; Qin, J; Tang, W; Teng, F; Wang, S; Wang, W; Wei, Y; Wuniqiemu, T; Zhu, X, 2021)
"In this study, we investigated whether 4-hydroxycinnamic acid (HA) has a palliative effect on asthmatic inflammatory responses using a mouse model of ovalbumin (OVA)-induced allergic asthma."3.964-Hydroxycinnamic acid suppresses airway inflammation and mucus hypersecretion in allergic asthma induced by ovalbumin challenge. ( Choi, SJ; Kim, JC; Kim, MS; Kim, SH; Kim, YH; Ko, JW; Kwon, HJ; Seo, CS; Shin, IS; Shin, NR, 2020)
"In vivo, mice were sensitized and challenged by ovalbumin (OVA) to induce asthma."3.96Monocyte chemotactic protein-inducing protein 1 negatively regulating asthmatic airway inflammation and mucus hypersecretion involving γ-aminobutyric acid type A receptor signaling pathway in vivo and in vitro. ( Chen, ZH; Dai, GM; Deng, HJ; Mao, RL; Ran, YJ; Wang, JJ; Zhu, T, 2020)
"Fifty rats (25 males and 25 females) were divided randomly into the control group, ovalbumin asthmatic model group, asthma low-, middle- and high-dose groups (n = 10, 5 males and 5 females each group)."3.96Effect of NF-κB signal pathway on mucus secretion induced by atmospheric PM ( Liu, Y; Peng, L; Wang, H; Zhang, B; Zhang, T; Zhou, L, 2020)
" argyi (TOTAL) and dehydromatricarin A (DA), its active component on ovalbumin (OVA)-induced allergic asthma."3.85Artemisia argyi attenuates airway inflammation in ovalbumin-induced asthmatic animals. ( Jeong, SH; Kim, HJ; Kim, JC; Ko, JW; Park, SH; Ryu, HW; Shin, IS; Shin, NR; Yuk, HJ, 2017)
" This study aimed to determine the possible effects and underlying mechanisms of Suhuang on chronic ovalbumin (OVA)-induced airway hyperresponsiveness (AHR), inflammation, and remodeling in mice."3.83Suhuang antitussive capsule at lower doses attenuates airway hyperresponsiveness, inflammation, and remodeling in a murine model of chronic asthma. ( Che, LQ; Chen, ZH; Lai, TW; Li, W; Shen, HH; Wang, HS; Wu, YF; Xiao, H; Ying, SM; Zhang, C; Zhang, LH, 2016)
"To observe the role of aminophylline and simvastatin in preventing and curing chronic obstructive pulmonary disease (COPD), and to explore the underlying mechanisms based on airway inflammation and mucus hypersecretion."3.83[Effect of aminophylline and simvastatin on airway inflammation and mucus hypersecretion in rats with chronic obstructive pulmonary disease]. ( Deng, X; Li, C; Ren, W; Wang, S; Xiong, L; Zhou, Q; Zhu, C, 2016)
" In addition, to investigate the effects of CuONPs on asthma development, we used a murine model of ovalbumin (OVA)-induced asthma."3.83Copper oxide nanoparticles aggravate airway inflammation and mucus production in asthmatic mice via MAPK signaling. ( Ahn, KS; Jeon, CM; Kim, JC; Ko, JW; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2016)
"To explore the preventive and therapeutic effects of simvastatin on rats with chronic obstructive pulmonary disease (COPD) and examine the mechanism of airway inflammation and airway mucus hypersecretion."3.81[Effects of simvastatin on airway inflammation and airway mucus hypersecretion in rats with chronic obstructive pulmonary disease]. ( Deng, X; Li, C; Ren, W; Wang, S; Xiong, L; Zhou, Q; Zhu, C, 2015)
"To explore the impact of ozone on the airway hyperresponsinveness (AHR), airway inflammation and mucus production in an allergic asthma mouse model."3.81[Effects of ozone oxidative stress on the airway hyperresponsiveness and mucus production in mice with acute allergic airway inflammation]. ( Aihua, B; Feng, L; Xin, Z; Yuqing, C; Zhang, M, 2015)
"Repeated inhalation of sevoflurane (SVF) can benefit asthmatic patients by bronchodilation."3.81Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation. ( Ding, PS; Fang, L; He, F; Liu, RY; Shen, QY; Wu, HM, 2015)
"The flavonoid naringenin has been shown to attenuate airway inflammation and airway hyper‑reactivity in acute murine models of asthma."3.80Naringenin inhibits allergen‑induced airway remodeling in a murine model of asthma. ( Gu, W; Mao, S; Shi, Y; Tan, Y, 2014)
"We investigated the suitability of dendritic polyglycerol sulfates (dPGS), conjugated with a hydrophilic version of the indocyanine green label with 6 sulfonate groups (6S-ICG) to monitor sites of inflammation using an experimental mouse model of allergic asthma."3.79Dendritic polyglycerolsulfate near infrared fluorescent (NIRF) dye conjugate for non-invasively monitoring of inflammation in an allergic asthma mouse model. ( Alves, F; Biffi, S; Bosnjak, B; Dal Monego, S; Dullin, C; Epstein, MM; Garrovo, C; Licha, K; Welker, P, 2013)
"In the OVA-exposed mice for 6 wks inflammatory cells infiltration, levels of inflammatory cytokines and chemokines, goblet cell metaplasia, collagen deposition and AHR were significantly decreased by treatment with AR inhibitor, fidarestat."3.79Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice. ( Aguilera-Aguirre, L; Boldogh, I; Boulares, HA; Calhoun, WJ; Naura, AS; Ramana, KV; Srivastava, SK; Yadav, UC, 2013)
" Multiwalled CNTs (MWCNTs) have been shown to exacerbate ovalbumin (OVA)-induced airway remodeling in mice."3.79Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes. ( Bonner, JC; Dackor, RT; Edin, ML; Glista-Baker, EE; Langenbach, R; Lih, FB; Sayers, BC; Shipley-Phillips, JK; Taylor, AJ; Tomer, KB; Zeldin, DC, 2013)
" Female BALB/c mice sensitized and challenged with ovalbumin developed airway inflammation."3.78Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB. ( Cheng, C; Goh, FY; Guan, S; Leung, BP; Sethi, G; Shanmugam, MK; Upton, N; Wong, WS, 2012)
"Verapamil is a useful drug with therapeutic targeting on GCH and a potential way to limit mucous production and improve bronchial inflammation."3.78Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals. ( Ghafarzadegan, K; Hadi, R; Khakzad, MR; Meshkat, M; Mirsadraee, M; Mohammadpour, A; Saghari, M, 2012)
"In the present study, we investigated whether the Lagerstroemia indica Linn (LI) extract has an anti-inflammatory effect on lung inflammation in ovalbumin-induced asthmatic mice."3.77Anti-inflammatory effects of ethanolic extract from Lagerstroemia indica on airway inflammation in mice. ( Kim, DH; Kim, IS; Lee, JS; Song, BB; Yang, EJ; Yun, CY, 2011)
"The purposes of this study were to determine whether curcumin inhibits NF-κB-dependent transcription in vitro, and test whether treatment with curcumin reduces allergen-induced airway inflammation and hyper-responsiveness in a mouse model of asthma through inhibition of NF-κB pathway."3.77Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-κB inhibition. ( Cha, JY; Chang, BC; Jung, JE; Kim, DY; Kwon, HJ; Lee, BR; Oh, SW, 2011)
" Becker (VM) ethanolic (EtOH) extract in the treatment of bronchial asthma in an ovalbumin (OVA)-induced asthmatic BALB/c mouse model."3.76Anti-inflammatory and anti-asthmatic effects of Viola mandshurica W. Becker (VM) ethanolic (EtOH) extract on airway inflammation in a mouse model of allergic asthma. ( Ahn, KS; Kim, HS; Kwon, OK; Lee, HK; Lee, MY; Oh, SR; Yuk, JE, 2010)
" The data showed that chronic SJ infection suppressed airway eosinophilia, mucus production and antigen-specific IgE responses induced by ovalbumin (OVA) sensitization and challenge."3.76Helminth infection inhibits airway allergic reaction and dendritic cells are involved in the modulation process. ( An, G; Gao, W; Ji, W; Li, J; Liu, P; Liu, X; Shen, Y; Wang, S; Wu, Z; Yang, X; Zhu, Y, 2010)
"ITE obtained from leaves by supercritical carbon dioxide extraction was investigated in ovalbumin (OVA) immunised BALB/c mice given intranasally together with antigen challenge in the murine model of allergic airway disease (asthma) with the analysis of the inflammatory and immune parameters in the lung."3.76The plant extract Isatis tinctoria L. extract (ITE) inhibits allergen-induced airway inflammation and hyperreactivity in mice. ( Brattström, A; Kamal, MA; Maillet, I; Moser, R; Ryffel, B; Schapowal, A, 2010)
" To clarify the effects of DE on the exacerbation of asthma, guinea pigs were exposed 12 h daily to 3 mg/m(3) DE or air for 8 wk with or without sensitization to ovalbumin (OVA)."3.71Exposure to diesel exhaust exacerbates allergen-induced airway responses in guinea pigs. ( Hashimoto, K; Hirano, K; Ishii, Y; Kimura, T; Masuyama, K; Morishima, Y; Nomura, A; Sagai, M; Sakamoto, T; Sekizawa, K; Takano, H; Uchida, Y, 2001)
"In the present study the antiinflammatory activity of fusidic acid was investigated in a model of formalin-induced edema formation in rats."3.71The effects of fusidic acid on the inflammatory response in rats. ( Batu, O; Erol, K; Kilic, FS; Usluer, G; Yildirim, E, 2002)
" The levels of 15-HETE extracted from tracheal mucus correlated well with hillocks and weight of secreted mucus found in the mucus after hypoxia or after arachidonic acid loading."3.6715-Hydroxyeicosatetraenoic acid is a potent inflammatory mediator and agonist of canine tracheal mucus secretion. ( Johnson, HG; McNee, ML; Sun, FF, 1985)
"Neutrophilic inflammation is believed to contribute to the airway obstruction and remodelling in equine asthma."2.90Randomised study of the immunomodulatory effects of azithromycin in severely asthmatic horses. ( Bédard, C; Hélie, P; Labrecque, O; Lavoie, JP; Mainguy-Seers, S; Vargas, A, 2019)
"Bronchiectasis is characterized by pathological and irreversible bronchial dilatation caused by the inefficient mucus and microorganism clearance and progression of inflammatory processes."2.87Effects of exercise on secretion transport, inflammation, and quality of life in patients with noncystic fibrosis bronchiectasis: Protocol for a randomized controlled trial. ( Baddini-Martinez, JA; de Souza, HCD; Dos Santos, DO; Gastaldi, AC; Ramos, EMC, 2018)
"Bronchiectasis is characterized by abnormal and permanent dilation of the bronchi, caused by the perpetuation of inflammation and impairment of mucociliary clearance."2.84Effects of an Airway Clearance Device on Inflammation, Bacteriology, and Mucus Transport in Bronchiectasis. ( Baddini-Martinez, JA; Barnes, PJ; de Souza, HCD; Gastaldi, AC; Martinez, R; Tambascio, J, 2017)
"Corticosteroid treatment reduces cough frequency concurrently with reductions in deltaPpl(max) and mucus accumulation in RAO-affected horses."2.71Coughing, mucus accumulation, airway obstruction, and airway inflammation in control horses and horses affected with recurrent airway obstruction. ( Berney, C; Cornelisse, CJ; deFeijter-Rupp, HL; Derksen, FJ; Eberhart, S; Gerber, VM; Jefcoat, AM; Robinson, NE, 2003)
"Allergic bronchial asthma is a chronic disease of the airways that is characterized by symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute episodes of broncho-obstruction."2.66More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis. ( Ehlers, JC; Frey, A; Lunding, LP; Weckmann, M; Wegmann, M; Zissler, UM, 2020)
"To develop an efficient therapy for chronic obstructive pulmonary disease (COPD), N-acetylcysteine (NAC) has been tested as a medication that can suppress various pathogenic processes in this disease."2.48N-Acetylcysteine mucolysis in the management of chronic obstructive pulmonary disease. ( Sadowska, AM, 2012)
"The number of senile patients with chronic obstructive pulmonary disease (COPD) has recently increased due to an increase in life expectancy, the habit of smoking and the inhalation of toxic particles."2.48Macrolide effects on the prevention of COPD exacerbations. ( Azuma, A; Kadota, J; Kudoh, S; Takizawa, H; Tamaoki, J; Yamaya, M, 2012)
"Chronic obstructive pulmonary disease (COPD) is characterized by poorly reversible airflow limitation associated with airway remodelling and inflammation of both large and small airways."2.47[Structural abnormalities and inflammation in COPD: a focus on small airways]. ( Bourdin, A; Burgel, PR; Chanez, P; Garcia, G; Pilette, C; Tillie-Leblond, I, 2011)
"The development of COPD is associated with chronic pulmonary inflammation."2.46[COPD and inflammation: statement from a French expert group: inflammation and remodelling mechanisms]. ( Aguilaniu, B; Aubier, M; Berger, P; Brillet, PY; Burgel, PR; Chambellan, A; Chanez, P; Chaouat, A; Devillier, P; Escamilla, R; Louis, R; Mal, H; Marthan, R; Muir, JF; Pérez, T; Roche, N; Similowski, T; Wallaert, B, 2010)
"Gastrointestinal inflammation is a prominent feature of protective reactions in animals immune against helminths."2.37Helminth-induced intestinal inflammation. ( Moqbel, R, 1986)
"Airway inflammation was also reduced in the Ac-DEVD group compared with the Smoke group, but the degree of emphysema was not significantly improved."1.91Effects of Z-VaD-Ala-Asp-Fluoromethyl Ketone (Z-VAD-FMK) and Acetyl-Asp-Glu-Val-Asp-Aldehyde(Ac-DEVD-CHO) on Inflammation and Mucus Secretion in Mice Exposed to Cigarette Smoke. ( He, M; Li, X; Shen, F; Zhang, G, 2023)
" Moreover, the thick colonic mucus layer obstructs the penetration of the drug, resulting in low bioavailability to the inflammatory site of the colon."1.72Mucus-Penetrating Alginate-Chitosan Nanoparticles Loaded with Berberine Hydrochloride for Oral Delivery to the Inflammation Site of Ulcerative Colitis. ( Chen, S; Fang, W; Gao, S; Hu, R; Lu, W; Nie, X; Sun, L; Zhang, Q, 2022)
"Formononetin has proven to be anti‑inflammatory and able to alleviate symptoms of certain allergic diseases."1.62Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells by activating the SIRT1/Nrf2 signaling pathway. ( Chen, X; Huang, J; Xie, A, 2021)
"Neutrophilic inflammation is characteristic of the disease, with elevated levels of harmful proteases such as neutrophil elastase associated with worse outcomes."1.62Pathophysiology of Bronchiectasis. ( Chalmers, JD; Keir, HR, 2021)
"BACKGROUND Chronic obstructive pulmonary disease (COPD) is a disease with high heterogeneity, which is a major challenge in clinical individualized treatment."1.62Identification of Mucus-Associated Molecular Subtypes of Chronic Obstructive Pulmonary Disease: A Latent Profile Analysis Based on MUC5B-Associated Genes. ( Chen, X; Cheng, X; Hu, Y; Qiu, Z, 2021)
"H9N2 subtype avian influenza virus (H9N2 AIV) is a low pathogenic virus that is widely prevalent all over the world."1.56Effect of Baicalin on Bacterial Secondary Infection and Inflammation Caused by H9N2 AIV Infection in Chickens. ( Chen, L; Chen, S; Ci, X; Li, H; Lian, J; Lin, W; Lv, H; Xie, Q; Xie, Z; Ye, Y; Zhang, H; Zhang, X; Zhao, Q, 2020)
"Based on a COPD rat model, the effects of OECC-BYF I-A~F on COPD rats were evaluated."1.56Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling. ( Dong, H; Feng, S; Li, J; Liu, S; Liu, X; Ma, J; Tian, Y; Wu, M; Zhang, L; Zhao, D; Zhao, P; Zheng, W; Zhu, L, 2020)
"Pneumocystis associates to more severe Chronic Obstructive Pulmonary Disease (COPD), asthma, respiratory distress of premature newborns, and is a consistent subclinical infection between 2 and 5 months of age when hospitalizations for respiratory cause and infant mortality are higher."1.51Increase in secreted airway mucins and partial Muc5b STAT6/FoxA2 regulation during Pneumocystis primary infection. ( Bórquez, P; Bustamante, R; Gallo, M; Iturra, PA; Méndez, A; Ponce, CA; Rojas, DA; Vargas, SL, 2019)
"Abundance is reduced in ulcerative colitis (UC), as is the relative proportion of sulphated mucin in the mucus gel layer (MGL)."1.51The abundance of Akkermansia muciniphila and its relationship with sulphated colonic mucins in health and ulcerative colitis. ( Balfe, Á; Coffey, JC; Earley, H; Lennon, G; O'Connell, PR; Winter, DC, 2019)
"serous middle ear effusions (MEEs)."1.48Characterization of mucoid and serous middle ear effusions from patients with chronic otitis media: implication of different biological mechanisms? ( Anna, K; Brown, K; Gordish-Dressman, H; Nino, G; Pérez-Losada, M; Poley, M; Preciado, D; Val, S, 2018)
"Ulcers were induced by serosal application of 80 % acetic acid to the stomach of rats anaesthetized with 50 mg/kg thiopentone sodium and treatment was given three times daily."1.46Effects of quinine on gastric ulcer healing in Wistar rats. ( Adeniyi, OS; Friday, ET; Makinde, OV; Olaleye, SB, 2017)
"TAS2R agonists attenuated features of airway remodeling including smooth muscle mass, extracellular matrix deposition and pro-fibrotic signaling, and also prevented mucus accumulation and development of AHR in mice."1.46Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice. ( Deshpande, DA; Knight, MJ; Nayak, AP; Oliver, B; Pan, S; Sharma, P; Tang, F; Wang, N; Yi, R, 2017)
"Mice lacking the endogenous β2-adrenoceptor (β2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of β2AR agonists to PNMT-KO mice restores the phenotype."1.43Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice. ( Al-Sawalha, N; Bond, RA; Forkuo, GS; Gonnella, PA; Joshi, R; Kim, H; Knoll, BJ; Parra, S; Penn, RB; Pera, T; Thanawala, VJ; Valdez, D; Walker, JK, 2016)
"Formaldehyde (FA) is an environmental pollutant widely used in industry."1.42Short-term exposure to formaldehyde promotes oxidative damage and inflammation in the trachea and diaphragm muscle of adult rats. ( Bandeira, AC; Bezerra, FS; Lima, LF; Lima, WG; Murta, GL; Nardeli, CR, 2015)
"The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade."1.42Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. ( Ahn, KS; Hong, JM; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2015)
"Chronic mucosal inflammation is the hallmark of important and common airway diseases, such as allergic rhinitis (AR) and asthma."1.42Lipoxin B₄ promotes the resolution of allergic inflammation in the upper and lower airways of mice. ( Haworth, O; Karra, L; Levi-Schaffer, F; Levy, BD; Priluck, R, 2015)
"Allergic rhinitis is a chronic inflammatory disease orchestrated by Th2 lymphocytes."1.40Regulation of nasal airway homeostasis and inflammation in mice by SHP-1 and Th2/Th1 signaling pathways. ( Cho, SH; Lane, AP; Lee, J; Lee, S; Oh, MH; Oh, SY; Zheng, T; Zhu, Z, 2014)
"Melatonin was administered by intraperitoneal injection once per day at doses of 10 and 15 mg/kg from days 21 to 23 after the initial OVA sensitization."1.40Melatonin reduces airway inflammation in ovalbumin-induced asthma. ( Ahn, KS; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2014)
"Chronic inflammation was induced in DSS and DSS + DMH group by administrating 2 % DSS in drinking water for 5 days followed by 5 days of normal drinking water and this constitutes one DSS cycle."1.39Mucus and adiponectin deficiency: role in chronic inflammation-induced colon cancer. ( Baliga, MS; Fayad, R; Fletcher, E; Greene, J; Kaur, K; Larsen, B; Ponemone, V; Saxena, A, 2013)
"Inflammation was induced by sensitization and chronic exposure of 16 C57BL/6 mice to Aspergillus fumigatus."1.38In vivo determination of mouse olfactory mucus cation concentrations in normal and inflammatory states. ( Conley, DB; Epstein, VA; Kern, RC; Liu, K; Richter, CP; Robinson, AM; Selvaraj, S, 2012)
"Inflammation was assessed by the total and differential cell counts and IL-4 and IL-5 levels in bronchoalveolar lavage (BAL) fluid."1.38The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma. ( Daubeuf, F; Frossard, N; Nemska, S; Reber, LL, 2012)
"Interestingly, pulmonary fibrosis observed in wild-type mice under the chronic protocol was completely absent in iNOS(-/-) mice despite persistent IL-5 and IL-13 production, suggesting that these cytokines were insufficient for pulmonary fibrosis."1.36Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation. ( Abd Elmageed, ZY; Boulares, AH; Errami, Y; Hans, CP; Ju, J; Kim, H; Naura, AS; Ochoa, AC; Park, J; Rodriguez, PC; Zerfaoui, M, 2010)
"Chronic obstructive pulmonary disease (COPD) is a chronic progressive inflammatory disease characterized by elevated lung neutrophils, macrophages, and CD8+ T lymphocytes and mucus hypersecretion."1.36Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung. ( Baccei, CS; Bain, G; Broadhead, AR; Coate, H; Evans, JF; Fagan, P; Hutchinson, JH; King, CD; Lorrain, DS; Prasit, P; Prodanovich, P; Santini, AM; Scott, JM; Stearns, BA; Stebbins, KJ; Stock, NS; Truong, YP, 2010)
"Adenosine is a signaling nucleoside that has been implicated in the regulation of asthma and chronic obstructive pulmonary disease."1.33A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury. ( Blackburn, MR; Molina, JG; Schnermann, J; Sun, CX; Volmer, JB; Young, HW, 2005)
"Human bronchial asthma is characterized by airway hyperresponsiveness (AHR), eosinophilic airway inflammation, mucus hypersecretion and high serum level of IgE."1.33Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness. ( Ishikawa, Y; Nakanishi, K; Yoshimoto, T, 2006)
" Importantly anti-TGF-beta Ab was administered therapeutically, with dosing starting after the onset of established eosinophilic airway inflammation."1.33Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway. ( Lloyd, CM; McMillan, SJ; Xanthou, G, 2005)
"Although cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the severity of disease is highly variable indicating the influence of modifier genes."1.33Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10. ( De Lisle, RC; Norkina, O, 2005)
"Acute bronchiolitis was induced by inhalation of nickel chloride aerosols for 5 days in Wistar rats according to the method described by Kyono et al."1.31Inflammatory responses and mucus secretion in rats with acute bronchiolitis induced by nickel chloride. ( Ishihara, Y; Kawashima, H; Kyono, H; Miyasaka, M; Serita, F; Toya, T, 2002)
"Airway inflammation is believed to stimulate mucus production in asthmatic patients."1.30Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. ( Bottomly, K; Cohn, L; Homer, RJ; Marinov, A; Rankin, J, 1997)
"Some of peribiliary cysts may be of congenital origin."1.28Pathological observations of intrahepatic peribiliary glands in 1,000 consecutive autopsy livers. III. Survey of necroinflammation and cystic dilatation. ( Nakanuma, Y; Terada, T, 1990)
"Mucoid enteritis was experimentally produced by ligating the large intestines in rabbits."1.27Experimental production of rabbit mucoid enteritis. ( Targowski, S; Toofanian, F, 1983)
"The suppression of delayed hypersensitivity (DH) in the lung as reflected by the appearance of mononuclear cells, mast cells and mucus-producing cells was studied in Balb/c mice."1.27Immunological suppression of delayed hypersensitivity responses in mouse lungs as reflected by numbers of mononuclear cells, mast cells and mucus-producing cells. ( Ahlstedt, S; Enander, I; Nygren, H, 1988)

Research

Studies (339)

TimeframeStudies, this research(%)All Research%
pre-199027 (7.96)18.7374
1990's31 (9.14)18.2507
2000's72 (21.24)29.6817
2010's135 (39.82)24.3611
2020's74 (21.83)2.80

Authors

AuthorsStudies
Saunders, MJ1
Edwards, BS1
Zhu, J4
Sklar, LA1
Graves, SW1
Campos-Sánchez, JC1
Vitarelli, E1
Guardiola, FA1
Ceballos-Francisco, D1
García Beltrán, JM1
Ieni, A1
Esteban, MÁ1
Lim, JO1
Lee, SJ2
Kim, WI2
Pak, SW2
Moon, C1
Shin, IS10
Heo, JD1
Ko, JW4
Kim, JC6
Huang, J2
Chen, X3
Xie, A1
Stamatiou, R1
Tsolaki, V1
Hatziefthimiou, A1
Zakynthinos, E1
Makris, D1
Reyes Nicolás, V1
Allaire, JM1
Alfonso, AB1
Pupo Gómez, D1
Pomerleau, V1
Giroux, V1
Boudreau, F1
Perreault, N1
Taoerdahong, H1
Zhou, K1
Yang, F1
Dong, CX1
Kiron, V1
Kathiresan, P1
Fernandes, JMO1
Sørensen, M1
Vasanth, GK1
Lin, Q2
Lim, TK1
Dahle, D1
Dias, J1
Trichet, VV1
Singanayagam, A1
Footitt, J1
Marczynski, M1
Radicioni, G3
Cross, MT1
Finney, LJ1
Trujillo-Torralbo, MB1
Calderazzo, M1
Aniscenko, J2
Clarke, TB1
Molyneaux, PL1
Bartlett, NW2
Moffatt, MF1
Cookson, WO1
Wedzicha, J1
Evans, CM2
Boucher, RC6
Kesimer, M4
Lieleg, O1
Mallia, P1
Johnston, SL2
Mann, TS1
Larcombe, AN1
Wang, KCW1
Shamsuddin, D1
Landwehr, KR1
Noble, PB1
Henry, PJ1
Batson, BD1
Zorn, BT1
Livengood, SS1
Kumagai, T1
Dang, H2
Ceppe, A1
Clapp, PW1
Tunney, M1
Elborn, JS2
McElvaney, NG2
Muhlebach, MS2
Tiemeyer, M1
Wolfgang, MC2
Wang, Z2
Xin, L1
Zhang, W3
Ma, J2
Morris, CR1
Habibovic, A1
Dustin, CM1
Schiffers, C1
Lin, MC1
Ather, JL1
Janssen-Heininger, YMW1
Poynter, ME3
Utermohlen, O1
Krönke, M1
van der Vliet, A2
Tao, X1
Liu, H1
Xia, J1
Zeng, P1
Wang, H4
Xie, Y1
Wang, C1
Cheng, Y1
Li, J5
Zhang, X4
Zhang, P1
Chen, S3
Yu, H2
Wu, H1
Wuniqiemu, T2
Teng, F2
Qin, J2
Lv, Y1
Nabijan, M1
Luo, Q1
Zhou, Y2
Cui, J2
Tang, W2
Zhu, X2
Wang, S8
Abduwaki, M1
Nurahmat, M1
Wei, Y2
Dong, JC1
Sun, L1
Nie, X1
Lu, W1
Zhang, Q4
Fang, W1
Gao, S1
Hu, R1
Chen, K2
Man, S1
Gao, C2
Li, X4
Liu, L2
Wang, Y3
Lu, F1
Wu, Z2
Ma, L1
Lin, P2
Dai, Z1
Lu, Z1
Yan, L1
Zhou, C2
Qian, ZJ1
Hong, P1
Li, C4
Aegerter, H1
Lambrecht, BN1
Oguma, A3
Shimizu, K3
Kimura, H3
Tanabe, N3
Sato, S3
Yokota, I3
Takimoto-Sato, M3
Matsumoto-Sasaki, M3
Abe, Y3
Takei, N3
Goudarzi, H3
Suzuki, M3
Makita, H3
Hirai, T3
Nishimura, M3
Konno, S3
Zhao, Y6
Hao, Q3
Yang, Y3
Ran, C3
Xu, Q3
Wu, C3
Liu, W3
Li, S3
Zhang, Z4
Zhou, Z3
Xu, M3
Hu, J4
Yang, L5
Gen, G3
Fu, Z4
Luo, Z3
Zou, W4
Waldstein, KA1
Ganama, M1
Varga, SM1
Tilley, S1
Hua, X1
Naama, M2
Telpaz, S1
Awad, A1
Ben-Simon, S1
Harshuk-Shabso, S1
Modilevsky, S1
Rubin, E1
Sawaed, J1
Zelik, L1
Zigdon, M1
Asulin, N1
Turjeman, S1
Werbner, M1
Wongkuna, S1
Feeney, R1
Schroeder, BO1
Nyska, A1
Nuriel-Ohayon, M1
Bel, S2
He, M1
Zhang, G1
Shen, F1
Zhang, B3
Fan, X2
Du, H1
Zhao, M1
Zhu, R1
He, B2
Zhang, Y5
Gu, N1
Briata, P1
Mastracci, L1
Zapparoli, E1
Caputo, L1
Ferracci, E1
Silvestri, A1
Garuti, A1
Hamadou, MH1
Inga, A1
Marcaccini, E1
Grillo, F1
Bucci, G1
Puri, PL1
Beznoussenko, G1
Mironov, A1
Chiacchiera, F1
Gherzi, R1
Wei, L1
Hongping, H1
Chufang, L1
Cuomu, M1
Jintao, L1
Kaiyin, C1
Lvyi, C1
Weiwu, C1
Zuguang, Y1
Nanshan, Z1
Zhang, H2
Zhou, X1
Shi, W1
Winter, MG1
Hughes, ER1
Muramatsu, MK1
Jimenez, AG1
Chanin, RB1
Spiga, L1
Gillis, CC1
McClelland, M1
Andrews-Polymenis, H1
Winter, SE1
Hou, Y1
Zheng, S1
Zou, F1
Wang, D3
Da, H1
Liu, J2
Zhao, H1
He, J1
Li, H3
Sun, X1
Liu, Y2
Trevizan-Bau, P1
Mazzone, SB1
Keeler, SP1
Wu, K1
Mao, D1
Li, M1
Iberg, CA1
Austin, SR1
Glaser, SA1
Yantis, J1
Podgorny, S1
Brody, SL2
Chartock, JR1
Han, Z1
Byers, DE1
Romero, AG1
Holtzman, MJ1
Vangay, P1
Ward, T1
Lucas, S1
Beura, LK1
Sabas, D1
Abramson, M1
Till, L1
Hoops, SL1
Kashyap, P1
Hunter, RC1
Masopust, D1
Knights, D1
Krimsky, W1
Neal Ii, RE1
Kim, V1
Wu, Y3
Guo, Y1
Huang, T2
Huang, D1
Shen, C1
Jiang, C1
Chen, H4
Liang, P1
Hu, Y2
Zheng, Z1
Liang, T1
Zhai, D1
Zhu, H1
Liu, Q1
Lee, IS1
Yang, YG1
Kim, T1
Leung, HM1
Birket, SE1
Hyun, C1
Ford, TN1
Cui, D1
Solomon, GM1
Shei, RJ1
Adewale, AT1
Lenzie, AR1
Fernandez-Petty, CM1
Zheng, H1
Palermo, JH1
Cho, DY1
Woodworth, BA1
Yonker, LM1
Hurley, BP1
Rowe, SM1
Tearney, GJ1
Lu, C1
Xu, T1
Bai, B1
Xiao, Z1
Wu, L1
Liang, G1
Dai, Y1
Liu, F2
Fu, J1
Bergstrom, K1
Shan, X1
McDaniel, JM1
McGee, S1
Bai, X1
Chen, W1
Xia, L1
Earley, H1
Lennon, G1
Balfe, Á1
Coffey, JC1
Winter, DC1
O'Connell, PR1
Balázs, A1
Mall, MA5
Kwon, HJ2
Seo, CS1
Choi, SJ1
Shin, NR6
Kim, SH1
Kim, YH1
Kim, MS1
Callaghan, MM1
Dillard, JP1
Zhang, T1
Peng, L1
Zhou, L2
Talbot, S1
Doyle, B1
Wang, JC1
Ahmadi, M1
Roberson, DP1
Yekkirala, A1
Foster, SL1
Browne, LE1
Bean, BP1
Levy, BD2
Woolf, CJ1
Amatngalim, GD1
Ribeiro, CMP1
Tian, Y1
Zhao, P1
Liu, X2
Dong, H1
Zheng, W1
Feng, S1
Zhang, L1
Wu, M3
Zhu, L1
Liu, S1
Zhao, D1
Sharma, A1
Raman, V1
Lee, J2
Forbes, NS1
Frey, A1
Lunding, LP1
Ehlers, JC1
Weckmann, M1
Zissler, UM1
Wegmann, M1
Cavalcanti, RFP1
Gadelha, FAAF1
de Jesus, TG1
Cavalcante-Silva, LHA1
Paiva Ferreira, LKD1
Paiva Ferreira, LAM1
Vieira, GC1
Piuvezam, MR1
Wheelock, CE1
Strandvik, B1
Xue, K1
Ruan, L1
Tian, D1
Dai, GM1
Wang, JJ1
Chen, ZH4
Ran, YJ1
Deng, HJ1
Mao, RL1
Zhu, T1
Arshad, T1
Mansur, F1
Palek, R1
Manzoor, S1
Liska, V1
Zhao, Q1
Ci, X1
Chen, L1
Lian, J1
Xie, Z1
Ye, Y1
Lv, H1
Lin, W1
Xie, Q1
Wang, T1
Wang, P1
Chen, D1
Xu, Z1
Dong, M1
Wang, W1
Dong, J1
Gugliandolo, E1
Cordaro, M1
Fusco, R1
Peritore, AF1
Siracusa, R1
Genovese, T1
D'Amico, R1
Impellizzeri, D1
Di Paola, R1
Cuzzocrea, S1
Crupi, R1
Brown, R1
Small, DM1
Doherty, DF1
Holsinger, L1
Booth, R1
Williams, R1
Ingram, RJ1
Taggart, CC1
Weldon, S1
Ude, VC1
Brown, DM1
Stone, V1
Johnston, HJ1
Xie, J1
Sun, H1
Wei, Q1
Nong, G1
Corcoran, TE1
Huber, AS1
Hill, SL1
Locke, LW1
Weber, L1
Muthukrishnan, A1
Heidrich, EM1
Wenzel, S1
Myerburg, MM1
Andelid, K1
Öst, K1
Andersson, A1
Mohamed, E1
Jevnikar, Z1
Vanfleteren, LEGW1
Göransson, M1
Dong, Y1
Yao, C1
Xu, R1
Tian, X1
Sweeter, JM1
Kudrna, K1
Hunt, K1
Thomes, P1
Dickey, BF2
Dickinson, JD1
Chikina, A1
Matic Vignjevic, D1
Lai, T1
Jing, D1
Yang, S1
Li, Z1
Shen, J1
Li, W4
Ying, S1
Chen, Z2
Wu, X1
Shen, H1
Hara, S1
Tojima, I1
Shimizu, S2
Kouzaki, H1
Shimizu, T2
Keir, HR1
Chalmers, JD1
Gao, W2
Jin, Z1
Zheng, Y1
Xu, Y1
Suárez, LJ1
Arboleda, S1
Angelov, N1
Arce, RM1
Choudhary, I1
Vo, T1
Paudel, K1
Yadav, R1
Mao, Y1
Patial, S1
Saini, Y2
Shastri, MD1
Allam, VSRR1
Shukla, SD1
Jha, NK1
Paudel, KR1
Peterson, GM1
Patel, RP1
Hansbro, PM1
Chellappan, DK1
Dua, K1
Centeio, R1
Ousingsawat, J1
Cabrita, I1
Schreiber, R1
Talbi, K1
Benedetto, R1
Doušová, T1
Verbeken, EK1
De Boeck, K1
Cohen, I1
Kunzelmann, K1
Zajac, D1
Cheng, X1
Qiu, Z1
Sharma, P1
Yi, R1
Nayak, AP1
Wang, N1
Tang, F1
Knight, MJ1
Pan, S1
Oliver, B1
Deshpande, DA1
Han, H1
Ziegler, SF1
Glymenaki, M1
Singh, G1
Brass, A1
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McBain, AJ1
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Cruickshank, SM1
Shah, SA1
Ishinaga, H1
Takeuchi, K1
Adeniyi, OS2
Makinde, OV1
Friday, ET1
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Tambascio, J1
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Martinez, R1
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Barnes, PJ2
Gastaldi, AC2
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Kim, HJ1
Jeong, SH1
Tulbah, AS1
Pisano, E1
Scalia, S1
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Patil, HP1
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Duncan, GA1
Ucakar, B1
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Li, YY1
Andiappan, AK1
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Tan, KS1
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Yu, FG1
Low, HB1
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Wang, DY1
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Gregory, LG1
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Lloyd, CM4
Snelgrove, RJ1
Wu, HM3
Wei, J1
Wang, K1
Qi, Y1
Wang, FY1
Ring, C1
Klopfleisch, R1
Dahlke, K1
Basic, M1
Bleich, A1
Blaut, M1
Rosa, MPG1
Jose, MMF1
Vanoni, S1
Scantamburlo, G1
Dossena, S1
Paulmichl, M1
Nofziger, C1
Laudisi, F1
Di Fusco, D1
Dinallo, V1
Stolfi, C1
Di Grazia, A1
Marafini, I1
Colantoni, A1
Ortenzi, A1
Alteri, C1
Guerrieri, F1
Mavilio, M1
Ceccherini-Silberstein, F1
Federici, M1
MacDonald, TT1
Monteleone, I1
Monteleone, G1
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Iturra, PA1
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Ponce, CA1
Bustamante, R1
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Bórquez, P1
Vargas, SL1
Park, HA1
Kwon, OK6
Min, JH1
Park, MW1
Park, MH1
Paik, JH1
Choi, S1
Paryanto, I1
Yuniato, P1
Oh, SR6
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Lee, JW1
Arnold, AR1
Chassaing, B1
Higham, A1
Quinn, AM1
Cançado, JED1
Singh, D1
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Chamignon, C1
Mhedbi-Hajri, N1
Chain, F1
Derrien, M1
Escribano-Vázquez, U1
Garault, P1
Cotillard, A1
Pham, HP1
Chervaux, C1
Bermúdez-Humarán, LG1
Smokvina, T1
Langella, P1
Esther, CR1
Ehre, C1
Hill, DB1
Ramsey, KA1
Markovetz, MR1
Garbarine, IC1
Forest, MG1
Seim, I1
Zorn, B1
Morrison, CB1
Delion, MF1
Thelin, WR1
Villalon, D1
Sabater, JR1
Turkovic, L1
Ranganathan, S1
Stick, SM1
Preska Steinberg, A1
Wang, ZG1
Ismagilov, RF1
Rohr, MW1
Narasimhulu, CA1
Rudeski-Rohr, TA1
Parthasarathy, S1
Mainguy-Seers, S1
Vargas, A1
Labrecque, O1
Bédard, C1
Hélie, P1
Lavoie, JP1
Nadel, JA4
Biffi, S1
Dal Monego, S1
Dullin, C1
Garrovo, C1
Bosnjak, B1
Licha, K1
Welker, P1
Epstein, MM2
Alves, F1
Yadav, UC1
Naura, AS3
Aguilera-Aguirre, L1
Boldogh, I1
Boulares, HA1
Calhoun, WJ1
Ramana, KV1
Srivastava, SK1
Lee, MY3
Jeon, WY2
Lim, HS1
Kim, JH2
Ha, H1
Marin, L1
Bebawy, M1
Colombo, P1
Buttini, F1
Haghi, M1
Young, P1
Saxena, A1
Baliga, MS1
Ponemone, V1
Kaur, K1
Larsen, B1
Fletcher, E1
Greene, J1
Fayad, R1
Shu, MH1
Appleton, D1
Zandi, K1
AbuBakar, S1
Graeber, SY2
Zhou-Suckow, Z2
Schatterny, J2
Hirtz, S2
Wei, M1
Xie, X1
Chu, X1
Yang, X3
Guan, M1
Sayers, BC1
Taylor, AJ1
Glista-Baker, EE1
Shipley-Phillips, JK1
Dackor, RT1
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Clinical Trials (18)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Double-blind Randomized Controlled Study of Linoleic Acid Supplementation for 1 Year in Patients With Cystic Fibrosis - Influence on Clinical Status and Metabolism[NCT04531410]80 participants (Anticipated)Interventional2021-10-25Enrolling by invitation
Comparison of Resistive Breathing Versus Inspiratory Hold Technique in Patients With Chronic Bronchitis[NCT05533931]26 participants (Anticipated)Interventional2022-09-30Not yet recruiting
Study of the Effect of FLUTTER VRP1 in Patients With Bronchiectasis.[NCT01209546]Phase 130 participants (Actual)Interventional2007-07-31Terminated (stopped due to The protocol finished.)
Moving Towards PREcision Medicine In United Airways Disease: Unraveling inflaMmatory Patterns in Asthmatic Patients With or Without Nasal Polyps (PREMIUM) - a Descriptive Pilot Study[NCT05009758]30 participants (Anticipated)Interventional2021-09-01Recruiting
A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754]Phase 20 participants (Actual)Interventional2021-04-01Withdrawn (stopped due to lack of subject enrollment)
A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483]Phase 28 participants (Actual)Interventional2020-11-06Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects)
Late Phase Administration Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation[NCT03513458]Phase 1/Phase 20 participants (Actual)Interventional2020-09-30Withdrawn (stopped due to [The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic.)
Early Phase Administration of Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation[NCT03513471]Phase 1/Phase 20 participants (Actual)Interventional2019-08-09Withdrawn (stopped due to The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic.)
Smoking Cessation on the Human Airway: Mucus Secretion, Inflammatory and Proteomic Profile in Nasal Lavage and miRNAs in Blood[NCT02136550]36 participants (Anticipated)Interventional2013-02-28Active, not recruiting
Evaluating the Effects of Curcumin in Moderate to Severe Asthmatics[NCT04353310]Phase 20 participants (Actual)Interventional2021-09-30Withdrawn (stopped due to No funding)
Phase Ib/II Clinical Trial of Topical Verapamil Hydrochloride for Chronic Rhinosinusitis With Nasal Polyps[NCT03102190]Phase 16 participants (Actual)Interventional2017-06-05Terminated (stopped due to Phase II funding not available)
Randomized Double Blind Placebo Controlled Trial of Verapamil in Chronic Rhinosinusitis[NCT02454608]29 participants (Actual)Interventional2015-05-31Terminated (stopped due to Evidence that the dose is insufficient.)
HYPERTONIC SALINE COATED FACE MASK FOR REDUCING RESPIRATORY SYMPTOM SEVERITY IN PATIENTS WITH COVID-19[NCT04465604]50 participants (Anticipated)Interventional2021-02-01Recruiting
Effect of Traditional Chinese Medicine on Gut Microbiota, Physical Constitution, and Allergic Diseases[NCT03033290]Phase 360 participants (Anticipated)Interventional2018-01-10Recruiting
Phase 3 Study of Qi-tonifying Chinese Herbal Products for Treatment of Allergic Rhinitis[NCT01631032]Phase 3112 participants (Actual)Interventional2012-07-31Completed
The Effect of Preoperative Antibiotics on Peri-implant Crestal Bone Remodelling and Postoperative Pain: A Randomized Controlled Trial[NCT04280406]Phase 150 participants (Anticipated)Interventional2020-02-25Recruiting
Comparison of Airway Remodeling Mediators Following Experimental Human Rhinovirus Infection in Subjects With Mild to Moderate Asthma and Healthy, Non-asthmatic Control Subjects[NCT05775952]24 participants (Anticipated)Observational2011-09-01Recruiting
Effect of Exposure to Allergens and Air Pollution on Lung Function and Immunity[NCT01792232]18 participants (Actual)Interventional2011-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Dose Limiting Toxicity

Dose Limiting Toxicity will be defined as a development of 2nd or 3rd degree heart block as measured by an EKG. (Phase Ib primary outcome) (NCT03102190)
Timeframe: 1-8 weeks

InterventionParticipants (Count of Participants)
Phase Ib0

Diastolic Blood Pressure

(NCT02454608)
Timeframe: Mean change between baseline and week 8 measurements

InterventionmmHg (Mean)
Treatment-0.6
Control1

Heart Rate

(NCT02454608)
Timeframe: Mean change between baseline and week 8 measurements.

Interventionbeats per minute (Mean)
Treatment-1.4
Control4

Objective Sinonasal Symptoms on Lund-Kennedy Score(LKS)

Minimum Score: 0 Maximum Score: 12 Higher value represents worse outcome. (NCT02454608)
Timeframe: baseline to week 8

Interventionunits on a scale (Least Squares Mean)
Treatment-1.3
Control-0.25

Objective Sinonasal Symptoms on Lund-McKay Score(LMS)

Minimum Score: 0 Maximum Score: 24 Higher value represents worse outcome. (NCT02454608)
Timeframe: Week 8

Interventionunits on a scale (Mean)
Treatment12.5
Control17.7

Subjective Sinonasal Symptoms on 10cm Visual Analogue Scale(VAS)

Minimum Score: 0 Maximum Score: 100 A higher score indicates a worse outcome. (NCT02454608)
Timeframe: baseline to week 8

Interventionunits on a scale (Least Squares Mean)
Treatment-44.03
Control-6.07

Subjective Sinonasal Symptoms on Sinonasal Outcomes Test-22(SNOT-22)

Minimum Score: 0 Maximum Score: 110 A higher score indicates a worse outcome (NCT02454608)
Timeframe: baseline to week 8

Interventionunits on a scale (Least Squares Mean)
Treatment-27.3
Control0.4

Systolic Blood Pressure

(NCT02454608)
Timeframe: Mean change between baseline and week 8 measurements

InterventionmmHg (Mean)
Treatment-4.5
Control-6.6

Subjective Sinonasal Symptoms on 10cm Visual Analogue Scale(VAS)

Minimum Score: 0 Maximum Score: 100 A higher score indicates a worse outcome. (NCT02454608)
Timeframe: baseline to week 56

Interventionunits on a scale (Mean)
Medicine Completers, baselineMedicine Completers, week 56Surgical Completers, baselineSurgical Completers, week 12
Open Label64.335.090.016.7

Subjective Sinonasal Symptoms on Sinonasal Outcomes Test-22(SNOT-22)

Minimum Score: 0 Maximum Score: 110 A higher score indicates a worse outcome (NCT02454608)
Timeframe: baseline to week 56

Interventionunits on a scale (Mean)
Medicine Completers, baselineMedicine Completers, week 56Surgical Completers, baselineSurgical Completers, week 12
Open Label31.824.1472.008.00

Reviews

67 reviews available for guaifenesin and Innate Inflammatory Response

ArticleYear
The Pathology of Asthma: What Is Obstructing Our View?
    Annual review of pathology, 2023, 01-24, Volume: 18

    Topics: Asthma; Humans; Inflammation; Mucus; Sputum

2023
Neuroimmune pathways regulating airway inflammation.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2023, Volume: 131, Issue:5

    Topics: Cough; Humans; Inflammation; Lung; Mucus; Pneumonia; Signal Transduction

2023
Airway Mucosal Remodeling: Mechanism of Action and Preclinical Data of Pulsed Electric Fields for Chronic Bronchitis and Mucus Hypersecretion.
    Respiration; international review of thoracic diseases, 2023, Volume: 102, Issue:11

    Topics: Animals; Bronchitis, Chronic; Goblet Cells; Humans; Inflammation; Mucous Membrane; Mucus; Quality of

2023
Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL-1 signaling pathway.
    Pediatric pulmonology, 2019, Volume: 54 Suppl 3

    Topics: Airway Obstruction; Animals; Child; Child, Preschool; Cystic Fibrosis; Disease Models, Animal; Human

2019
More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Airway Remodeling; Animals; Asthma; Chemokines; Epithelial Cells; Epithelium; Humans; Immunoglobulin

2020
Abnormal n-6 fatty acid metabolism in cystic fibrosis contributes to pulmonary symptoms.
    Prostaglandins, leukotrienes, and essential fatty acids, 2020, Volume: 160

    Topics: Arachidonic Acid; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Docosahexaen

2020
A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Animals; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Arthritis, Rheumatoid; Carcino

2020
At the right time in the right place: How do luminal gradients position the microbiota along the gut?
    Cells & development, 2021, Volume: 168

    Topics: Gastrointestinal Microbiome; Humans; Inflammation; Microbiota; Mucus; Symbiosis

2021
Oral Versus Gastrointestinal Mucosal Immune Niches in Homeostasis and Allostasis.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Adaptive Immunity; Allostasis; Animals; Antigen Presentation; Bacterial Translocation; Cell Adhesion

2021
Interleukin-13: A pivotal target against influenza-induced exacerbation of chronic lung diseases.
    Life sciences, 2021, Oct-15, Volume: 283

    Topics: Chronic Disease; Humans; Inflammation; Influenza, Human; Interleukin-13; Lung Diseases; Mucus

2021
Inhalations with thermal waters in respiratory diseases.
    Journal of ethnopharmacology, 2021, Dec-05, Volume: 281

    Topics: Administration, Inhalation; Animals; Bacterial Infections; Balneology; History, 19th Century; Histor

2021
Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia.
    International journal of molecular sciences, 2019, Feb-09, Volume: 20, Issue:3

    Topics: Animals; Biomarkers; Esophageal Mucosa; Gene Expression Regulation; Humans; Inflammation; Interleuki

2019
The pathology of small airways disease in COPD: historical aspects and future directions.
    Respiratory research, 2019, Mar-04, Volume: 20, Issue:1

    Topics: Airway Remodeling; Animals; Disease Progression; Forecasting; Humans; Inflammation; Lung; Mucus; Pul

2019
Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review.
    Advances in nutrition (Bethesda, Md.), 2020, 01-01, Volume: 11, Issue:1

    Topics: Animals; Bile Acids and Salts; Cytokines; Diet, High-Fat; Dietary Fats; Gastrointestinal Microbiome;

2020
A tale of two sites: how inflammation can reshape the microbiomes of the gut and lungs.
    Journal of leukocyte biology, 2016, Volume: 100, Issue:5

    Topics: Anaerobiosis; Colitis; Cystic Fibrosis; Escherichia coli Infections; Feedback, Physiological; Gammap

2016
Immunological aspects of intestinal mucus and mucins.
    Nature reviews. Immunology, 2016, Volume: 16, Issue:10

    Topics: Animals; Gastrointestinal Microbiome; Goblet Cells; Humans; Inflammation; Intestinal Mucosa; Mucins;

2016
Airway mucus, inflammation and remodeling: emerging links in the pathogenesis of chronic lung diseases.
    Cell and tissue research, 2017, Volume: 367, Issue:3

    Topics: Airway Remodeling; Animals; Chronic Disease; Humans; Inflammation; Lung; Lung Diseases; Mucus

2017
Alternative mechanisms for tiotropium.
    Pulmonary pharmacology & therapeutics, 2009, Volume: 22, Issue:6

    Topics: Acetylcholine; Animals; Bronchodilator Agents; Cholinergic Antagonists; Cough; Humans; Inflammation;

2009
Rhinogenic laryngitis, cough, and the unified airway.
    Otolaryngologic clinics of North America, 2010, Volume: 43, Issue:1

    Topics: Cough; Humans; Inflammation; Laryngitis; Mucus; Nose Diseases; Respiratory System

2010
Current perspectives of oxidative stress and its measurement in chronic obstructive pulmonary disease.
    COPD, 2010, Volume: 7, Issue:4

    Topics: Antioxidants; Apoptosis; Biomarkers; Histone Acetyltransferases; Humans; Inflammation; Lung; Mucus;

2010
[Mechanotransduction and the bronchoalveolar epithelium].
    Revue des maladies respiratoires, 2010, Volume: 27, Issue:10

    Topics: Apoptosis; Asthma; Bronchi; Cilia; Collagen; Cytokines; Epithelial Cells; Epithelium; ErbB Receptors

2010
[COPD and inflammation: statement from a French expert group: inflammation and remodelling mechanisms].
    Revue des maladies respiratoires, 2010, Volume: 27, Issue:10

    Topics: Airway Remodeling; Anemia; Antigens; Antioxidants; Bronchitis; Cardiovascular Diseases; Comorbidity;

2010
A view on imaging in drug research and development for respiratory diseases.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 337, Issue:2

    Topics: Animals; Clinical Trials as Topic; Diagnostic Imaging; Disease Models, Animal; Drug Delivery Systems

2011
The sentinel role of the airway epithelium in asthma pathogenesis.
    Immunological reviews, 2011, Volume: 242, Issue:1

    Topics: Adaptive Immunity; Adult; Airway Remodeling; Allergens; Animals; Anti-Inflammatory Agents; Asthma; C

2011
[Structural abnormalities and inflammation in COPD: a focus on small airways].
    Revue des maladies respiratoires, 2011, Volume: 28, Issue:6

    Topics: Adaptive Immunity; Airway Remodeling; Apoptosis; Autoimmunity; Bronchioles; Chemotaxis, Leukocyte; C

2011
N-Acetylcysteine mucolysis in the management of chronic obstructive pulmonary disease.
    Therapeutic advances in respiratory disease, 2012, Volume: 6, Issue:3

    Topics: Acetylcysteine; Expectorants; Gene Expression Regulation; Humans; Inflammation; Mucins; Mucus; Oxida

2012
Macrolide effects on the prevention of COPD exacerbations.
    The European respiratory journal, 2012, Volume: 40, Issue:2

    Topics: Anti-Inflammatory Agents; Antiviral Agents; Azithromycin; Biofilms; Bronchodilator Agents; Clinical

2012
Hypertonic saline in treatment of pulmonary disease in cystic fibrosis.
    TheScientificWorldJournal, 2012, Volume: 2012

    Topics: Adolescent; Animals; Anti-Infective Agents; Child; Child, Preschool; Cystic Fibrosis; Cystic Fibrosi

2012
Non-allergic models of mucous cell metaplasia and mucus hypersecretion in rat nasal and pulmonary airways.
    Novartis Foundation symposium, 2002, Volume: 248

    Topics: Animals; Drosophila Proteins; Endotoxins; Epithelial Cells; ErbB Receptors; Exocrine Glands; Exocyto

2002
Increasing the quantity of lungs for transplantation using high-frequency chest wall oscillation: a proposal.
    Progress in transplantation (Aliso Viejo, Calif.), 2002, Volume: 12, Issue:4

    Topics: Blood Gas Analysis; Brain Death; Chest Wall Oscillation; Evidence-Based Medicine; Humans; Inflammati

2002
Airway sensory innervation as a target for novel therapies: an outdated concept?
    Current opinion in pharmacology, 2003, Volume: 3, Issue:3

    Topics: Bronchoconstriction; Drug Delivery Systems; Humans; Inflammation; Mucus; Nerve Fibers, Unmyelinated;

2003
Chronic Pseudomonas aeruginosa infection in cystic fibrosis airway disease: metabolic changes that unravel novel drug targets.
    Expert review of anti-infective therapy, 2004, Volume: 2, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Biofilms; Child; Chronic Disease; Cystic Fibrosis; Humans; Inflammat

2004
Clinical implications of the immunomodulatory effects of macrolides.
    The American journal of medicine, 2004, Nov-08, Volume: 117 Suppl 9A

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Chronic Disease; Cytokines; Humans; Immune System;

2004
Immunomodulatory effects of antimicrobials in the therapy of respiratory tract infections.
    Current opinion in infectious diseases, 2005, Volume: 18, Issue:2

    Topics: Anti-Bacterial Agents; Asthma; Bronchiolitis; Cystic Fibrosis; Cytokines; Gene Expression; Humans; I

2005
Genetics of chronic obstructive pulmonary disease, beyond a1-antitrypsin deficiency.
    Current medicinal chemistry, 2006, Volume: 13, Issue:24

    Topics: Alleles; alpha 1-Antitrypsin Deficiency; Homozygote; Humans; Inflammation; Matrix Metalloproteinases

2006
Novel medications for asthma: a look at the future.
    Expert opinion on investigational drugs, 2007, Volume: 16, Issue:6

    Topics: Airway Obstruction; Animals; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Drug Delivery

2007
IL-13 as a therapeutic target for respiratory disease.
    Biochemical pharmacology, 2008, Jul-15, Volume: 76, Issue:2

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Fibrosis; Humans; Inflammation; Interleukin-13; Interleu

2008
Proteases, antiproteases, and oxidants: pathways of tissue injury during inflammation.
    Monographs in pathology, 1982, Issue:23

    Topics: alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; alpha-Macroglobulins; Animals; Chymotrypsin; Endopept

1982
Pathogenesis of chronic bronchitis.
    Seminars in respiratory infections, 1994, Volume: 9, Issue:1

    Topics: Bronchitis; Chemotactic Factors; Chemotaxis, Leukocyte; Chronic Disease; Humans; Inflammation; Leuko

1994
[Bronchial hyperreactivity: neurogenic factors].
    Revue des maladies respiratoires, 1994, Volume: 11, Issue:2

    Topics: Adrenergic Fibers; Afferent Pathways; Asthma; Autonomic Nervous System; Bronchial Hyperreactivity; C

1994
The human mast cell.
    The Journal of allergy and clinical immunology, 1997, Volume: 99, Issue:2

    Topics: Bronchoconstriction; Cell Communication; Cell Differentiation; Cell Division; Cytokines; Edema; Endo

1997
[Pharmacology of airway inflammation--special reference to hypersecretion of the mucous].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1996, Volume: 108, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Humans; Inflammation; Mucociliary Clearance; Mucous Membrane; Muc

1996
Smooth muscle as a direct or indirect target accounting for bronchopulmonary hyperresponsiveness.
    Research in immunology, 1997, Volume: 148, Issue:1

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Humans; Inflammation; Inflammation

1997
Implications of early inflammation and infection in cystic fibrosis: a review of new and potential interventions.
    Pediatric pulmonology, 1997, Volume: 24, Issue:2

    Topics: Cystic Fibrosis; Humans; Inflammation; Mucus

1997
Current opinion of muco-active drug research: strategies and problems.
    The European respiratory journal, 1998, Volume: 11, Issue:2

    Topics: Anti-Inflammatory Agents; Glucocorticoids; Humans; Inflammation; Medicine, Chinese Traditional; Muco

1998
Bacterial toxins which perturb ciliary function and respiratory epithelium.
    Symposium series (Society for Applied Microbiology), 1998, Volume: 27

    Topics: Animals; Bacterial Toxins; Cilia; Epithelium; Humans; In Vitro Techniques; Inflammation; Microscopy,

1998
[Roles of airway inflammation in chronic airflow obstruction].
    Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57, Issue:9

    Topics: Elasticity; Humans; Inflammation; Leukocytes; Lung; Lung Diseases; Lung Diseases, Obstructive; Macro

1999
Oxidants, nitrosants, and the lung.
    The American journal of medicine, 2000, Oct-01, Volume: 109, Issue:5

    Topics: Antioxidants; Bronchoalveolar Lavage Fluid; Epithelial Cells; Humans; Immunity, Cellular; Inflammati

2000
Leukotrienes as mediators of asthma.
    Pulmonary pharmacology & therapeutics, 2001, Volume: 14, Issue:1

    Topics: Animals; Asthma; Cell Division; Humans; Inflammation; Leukotriene Antagonists; Leukotrienes; Mucus;

2001
Novel mechanistic targets for the treatment of sub-acute and chronic bronchitis.
    Current pharmaceutical design, 2001, Volume: 7, Issue:3

    Topics: Adrenal Cortex Hormones; Antioxidants; Bronchitis; Bronchodilator Agents; Cystic Fibrosis; Humans; I

2001
Remodeling in response to infection and injury. Airway inflammation and hypersecretion of mucus in smoking subjects with chronic obstructive pulmonary disease.
    American journal of respiratory and critical care medicine, 2001, Nov-15, Volume: 164, Issue:10 Pt 2

    Topics: Biopsy; Bronchitis; CD4-CD8 Ratio; Chronic Disease; Goblet Cells; Humans; Hyperplasia; Inflammation;

2001
Crohn's disease: electron microscopic studies.
    Pathology annual, 1979, Volume: 14 Pt 2

    Topics: Adolescent; Adult; Aged; Autonomic Nervous System; Colon; Colonic Diseases; Crohn Disease; Eosinophi

1979
Asthma: the important questions. Part 2.
    The American review of respiratory disease, 1992, Volume: 146, Issue:5 Pt 1

    Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Body Temperature Regulation; Chronic Dise

1992
Mucus production in the lower airways. A review of experimental studies.
    Danish medical bulletin, 1992, Volume: 39, Issue:4

    Topics: Airway Obstruction; Autonomic Nervous System; Bronchi; Enzymes; Humans; Inflammation; Models, Biolog

1992
Mucus secretion and inflammation.
    Pulmonary pharmacology, 1992, Volume: 5, Issue:2

    Topics: Animals; Arachidonic Acids; Bradykinin; Exocrine Glands; Humans; Inflammation; Mucus; Sputum

1992
Control of mucus secretion in airways.
    Respiration; international review of thoracic diseases, 1991, Volume: 58, Issue:1

    Topics: Air Pollutants; Animals; Humans; Inflammation; Mucus; Neurotransmitter Agents; Respiratory System

1991
Plasma exudation in the airways: mechanisms and function.
    The European respiratory journal, 1991, Volume: 4, Issue:10

    Topics: Animals; Exudates and Transudates; Humans; Inflammation; Mucous Membrane; Mucus; Plasma; Respiratory

1991
Roles of neutral endopeptidase in airways.
    The American journal of physiology, 1991, Volume: 260, Issue:4 Pt 1

    Topics: Amino Acid Sequence; Animals; Hormones; Inflammation; Molecular Sequence Data; Mucus; Neprilysin; Re

1991
Pathogenesis of airway mucus hypersecretion.
    The Journal of allergy and clinical immunology, 1990, Volume: 85, Issue:2

    Topics: Animals; Exocrine Glands; Humans; Hypersensitivity, Immediate; Inflammation; Mast Cells; Mucus; Neur

1990
Mechanisms of glucocorticosteroid action in bronchial asthma.
    The Journal of allergy and clinical immunology, 1985, Volume: 76, Issue:2 Pt 2

    Topics: Adenylyl Cyclases; Arachidonic Acid; Arachidonic Acids; Asthma; Basophils; Bronchial Spasm; Capillar

1985
Helminth-induced intestinal inflammation.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1986, Volume: 80, Issue:5

    Topics: Animals; Eosinophils; Helminthiasis; Humans; Immunoglobulin E; Inflammation; Intestinal Diseases, Pa

1986
Secretion and ion transport in airways during inflammation.
    Biorheology, 1987, Volume: 24, Issue:6

    Topics: Animals; Biological Transport, Active; Chlorides; Dogs; Inflammation; Mucus; Respiratory System

1987
Vegetable dust and airway disease: inflammatory mechanisms.
    Environmental health perspectives, 1986, Volume: 66

    Topics: Animals; Antibody Formation; Blood Platelets; Byssinosis; Complement System Proteins; Dust; Edible G

1986
Mucosal immunological protection mechanisms in the airways.
    European journal of respiratory diseases. Supplement, 1986, Volume: 147

    Topics: Antibody Formation; Bronchi; Humans; Immune System; Immunoglobulin A; Inflammation; Interleukin-1; L

1986
Mucus transport and inflammation.
    European journal of respiratory diseases. Supplement, 1986, Volume: 147

    Topics: Biological Transport, Active; Cilia; Humans; Inflammation; Microscopy, Electron; Microscopy, Electro

1986
Small airways disease.
    Human pathology, 1973, Volume: 4, Issue:2

    Topics: Airway Obstruction; Airway Resistance; Animals; Bronchitis; Chronic Disease; Dogs; Humans; Inflammat

1973
Sites and mechanisms of airway obstruction in COPD.
    Postgraduate medicine, 1973, Volume: 54, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Airway Obstruction; Airway Resistance; Bronchi; Child; Child,

1973

Trials

6 trials available for guaifenesin and Innate Inflammatory Response

ArticleYear
Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies.
    Science translational medicine, 2019, 08-07, Volume: 11, Issue:504

    Topics: Case-Control Studies; Cilia; Cystic Fibrosis; Granulocytes; Humans; Imaging, Three-Dimensional; Infl

2019
Effects of an Airway Clearance Device on Inflammation, Bacteriology, and Mucus Transport in Bronchiectasis.
    Respiratory care, 2017, Volume: 62, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Airway Management; Bronchiectasis; Cough; Cross-Over Studies; Female

2017
Effects of exercise on secretion transport, inflammation, and quality of life in patients with noncystic fibrosis bronchiectasis: Protocol for a randomized controlled trial.
    Medicine, 2018, Volume: 97, Issue:7

    Topics: Adolescent; Adult; Bronchiectasis; Clinical Protocols; Exercise; Exercise Therapy; Female; Heart Rat

2018
Randomised study of the immunomodulatory effects of azithromycin in severely asthmatic horses.
    The Veterinary record, 2019, 08-03, Volume: 185, Issue:5

    Topics: Airway Remodeling; Animals; Asthma; Azithromycin; Cross-Over Studies; Female; Horse Diseases; Horses

2019
The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs.
    International immunopharmacology, 2002, Volume: 2, Issue:12

    Topics: Adolescent; Adult; Apoptosis; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 2; Dinopro

2002
The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs.
    International immunopharmacology, 2002, Volume: 2, Issue:12

    Topics: Adolescent; Adult; Apoptosis; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 2; Dinopro

2002
The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs.
    International immunopharmacology, 2002, Volume: 2, Issue:12

    Topics: Adolescent; Adult; Apoptosis; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 2; Dinopro

2002
The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs.
    International immunopharmacology, 2002, Volume: 2, Issue:12

    Topics: Adolescent; Adult; Apoptosis; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 2; Dinopro

2002
Coughing, mucus accumulation, airway obstruction, and airway inflammation in control horses and horses affected with recurrent airway obstruction.
    American journal of veterinary research, 2003, Volume: 64, Issue:5

    Topics: Airway Obstruction; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cough; Dexameth

2003

Other Studies

266 other studies available for guaifenesin and Innate Inflammatory Response

ArticleYear
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
    Current protocols in cytometry, 2010, Volume: Chapter 13

    Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr

2010
Implication of mucus-secreting cells, acidophilic granulocytes and monocytes/macrophages in the resolution of skin inflammation caused by subcutaneous injection of λ/κ-carrageenin to gilthead seabream (Sparus aurata) specimens.
    Journal of fish diseases, 2022, Volume: 45, Issue:1

    Topics: Animals; Carrageenan; Fish Diseases; Granulocytes; Inflammation; Injections, Subcutaneous; Macrophag

2022
Titanium Dioxide Nanoparticles Exacerbate Allergic Airway Inflammation via TXNIP Upregulation in a Mouse Model of Asthma.
    International journal of molecular sciences, 2021, Sep-14, Volume: 22, Issue:18

    Topics: Animals; Apoptosis; Asthma; bcl-2-Associated X Protein; Bronchoalveolar Lavage Fluid; Carrier Protei

2021
Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells by activating the SIRT1/Nrf2 signaling pathway.
    Molecular medicine reports, 2021, Volume: 24, Issue:6

    Topics: Anti-Inflammatory Agents; Cytokines; Epithelial Cells; Humans; Inflammation; Interleukin-13; Isoflav

2021
Evaluation of airway inflammation in mechanically ventilated patients using cell count and protein concentration.
    Scientific reports, 2021, 10-05, Volume: 11, Issue:1

    Topics: Aged; Biomarkers; Bronchoscopy; C-Reactive Protein; Case-Control Studies; Cell Count; Disease Suscep

2021
Altered Mucus Barrier Integrity and Increased Susceptibility to Colitis in Mice upon Loss of Telocyte Bone Morphogenetic Protein Signalling.
    Cells, 2021, 10-29, Volume: 10, Issue:11

    Topics: Animals; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Colitis; Colon;

2021
Structure, immunostimulatory activity, and the effect of ameliorating airway inflammation of polysaccharides from Pyrus sinkiangensis Yu.
    International journal of biological macromolecules, 2022, Jan-15, Volume: 195

    Topics: Adjuvants, Immunologic; Animals; Bronchoalveolar Lavage Fluid; Cell Survival; Chromatography, Ion Ex

2022
Clues from the intestinal mucus proteome of Atlantic salmon to counter inflammation.
    Journal of proteomics, 2022, 03-20, Volume: 255

    Topics: Animal Feed; Animals; Chromatography, Liquid; Diet; Inflammation; Intestines; Mucus; Proteome; Salmo

2022
Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease.
    The Journal of clinical investigation, 2022, 04-15, Volume: 132, Issue:8

    Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Humans; Inflammation; Mice; Mucin 5AC; Muci

2022
Azithromycin inhibits mucin secretion, mucous metaplasia, airway inflammation, and airways hyperresponsiveness in mice exposed to house dust mite extract.
    American journal of physiology. Lung cellular and molecular physiology, 2022, 05-01, Volume: 322, Issue:5

    Topics: Adenosine Triphosphate; Allergens; Animals; Asthma; Azithromycin; Disease Models, Animal; Inflammati

2022
Cystic Fibrosis Airway Mucus Hyperconcentration Produces a Vicious Cycle of Mucin, Pathogen, and Inflammatory Interactions that Promotes Disease Persistence.
    American journal of respiratory cell and molecular biology, 2022, Volume: 67, Issue:2

    Topics: Cystic Fibrosis; Humans; Inflammation; Mucin 5AC; Mucin-5B; Mucus; Proteomics; Respiratory System

2022
Study Effect of Azithromycin and Doxycycline in Mucus Producing and Inflammatory Signaling Pathways of Allergic Asthma.
    Iranian journal of allergy, asthma, and immunology, 2022, Apr-11, Volume: 21, Issue:2

    Topics: Animals; Asthma; Azithromycin; Cyclooxygenase 2; Doxycycline; Humans; Immunoglobulin E; Inflammation

2022
Infection and Inflammation MUC up the Cystic Fibrosis Airway.
    American journal of respiratory cell and molecular biology, 2022, Volume: 67, Issue:2

    Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Inflammation; Mucins;

2022
Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during allergic airway disease.
    Mucosal immunology, 2022, Volume: 15, Issue:5

    Topics: Airway Remodeling; Allergens; Animals; Antigens, Dermatophagoides; Dual Oxidases; Hypersensitivity;

2022
Processed product (Pinelliae Rhizoma Praeparatum) of Pinellia ternata (Thunb.) Breit. Alleviates the allergic airway inflammation of cold phlegm via regulation of PKC/EGFR/MAPK/PI3K-AKT signaling pathway.
    Journal of ethnopharmacology, 2022, Sep-15, Volume: 295

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; ErbB Receptors; Expectorants; Inflammation

2022
Iristectorigenin A exerts novel protective properties against airway inflammation and mucus hypersecretion in OVA-induced asthmatic mice: Iristectorigenin A ameliorates asthma phenotype.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 104

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Immunoglobulin E; Immunoglobu

2022
Mucus-Penetrating Alginate-Chitosan Nanoparticles Loaded with Berberine Hydrochloride for Oral Delivery to the Inflammation Site of Ulcerative Colitis.
    AAPS PharmSciTech, 2022, Jun-27, Volume: 23, Issue:6

    Topics: Administration, Oral; Alginates; Berberine; Chitosan; Colitis, Ulcerative; Drug Carriers; Drug Deliv

2022
Dysregulation of intestinal flora: excess prepackaged soluble fibers damage the mucus layer and induce intestinal inflammation.
    Food & function, 2022, Aug-15, Volume: 13, Issue:16

    Topics: Animals; Diet, High-Fat; Gastrointestinal Microbiome; Inflammation; Mice; Mice, Inbred C57BL; Mucus;

2022
Extracellular vesicles derived from Pinctada martensii mucus regulate skin inflammation via the NF-κB/NLRP3/MAPK pathway.
    Biochemical and biophysical research communications, 2022, 12-17, Volume: 634

    Topics: Animals; Dermatitis; Extracellular Vesicles; Humans; Inflammasomes; Inflammation; Mitogen-Activated

2022
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish.
    Fish & shellfish immunology, 2022, Volume: 131

    Topics: Animals; Diet, High-Fat; Gastrointestinal Microbiome; Inflammation; Interleukin-10; Interleukin-6; L

2022
Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish.
    Fish & shellfish immunology, 2022, Volume: 131

    Topics: Animals; Diet, High-Fat; Gastrointestinal Microbiome; Inflammation; Interleukin-10; Interleukin-6; L

2022
Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish.
    Fish & shellfish immunology, 2022, Volume: 131

    Topics: Animals; Diet, High-Fat; Gastrointestinal Microbiome; Inflammation; Interleukin-10; Interleukin-6; L

2022
Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish.
    Fish & shellfish immunology, 2022, Volume: 131

    Topics: Animals; Diet, High-Fat; Gastrointestinal Microbiome; Inflammation; Interleukin-10; Interleukin-6; L

2022
Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish.
    Fish & shellfish immunology, 2022, Volume: 131

    Topics: Animals; Diet, High-Fat; Gastrointestinal Microbiome; Inflammation; Interleukin-10; Interleukin-6; L

2022
Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish.
    Fish & shellfish immunology, 2022, Volume: 131

    Topics: Animals; Diet, High-Fat; Gastrointestinal Microbiome; Inflammation; Interleukin-10; Interleukin-6; L

2022
Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish.
    Fish & shellfish immunology, 2022, Volume: 131

    Topics: Animals; Diet, High-Fat; Gastrointestinal Microbiome; Inflammation; Interleukin-10; Interleukin-6; L

2022
Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish.
    Fish & shellfish immunology, 2022, Volume: 131

    Topics: Animals; Diet, High-Fat; Gastrointestinal Microbiome; Inflammation; Interleukin-10; Interleukin-6; L

2022
Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish.
    Fish & shellfish immunology, 2022, Volume: 131

    Topics: Animals; Diet, High-Fat; Gastrointestinal Microbiome; Inflammation; Interleukin-10; Interleukin-6; L

2022
Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation.
    Molecular immunology, 2023, Volume: 153

    Topics: Animals; Humans; Inflammation; Lung; Mice; Mice, Inbred C57BL; Mucus; Pyroglyphidae

2023
Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation.
    Molecular immunology, 2023, Volume: 153

    Topics: Animals; Humans; Inflammation; Lung; Mice; Mice, Inbred C57BL; Mucus; Pyroglyphidae

2023
Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation.
    Molecular immunology, 2023, Volume: 153

    Topics: Animals; Humans; Inflammation; Lung; Mice; Mice, Inbred C57BL; Mucus; Pyroglyphidae

2023
Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation.
    Molecular immunology, 2023, Volume: 153

    Topics: Animals; Humans; Inflammation; Lung; Mice; Mice, Inbred C57BL; Mucus; Pyroglyphidae

2023
Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation.
    Molecular immunology, 2023, Volume: 153

    Topics: Animals; Humans; Inflammation; Lung; Mice; Mice, Inbred C57BL; Mucus; Pyroglyphidae

2023
Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation.
    Molecular immunology, 2023, Volume: 153

    Topics: Animals; Humans; Inflammation; Lung; Mice; Mice, Inbred C57BL; Mucus; Pyroglyphidae

2023
Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation.
    Molecular immunology, 2023, Volume: 153

    Topics: Animals; Humans; Inflammation; Lung; Mice; Mice, Inbred C57BL; Mucus; Pyroglyphidae

2023
Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation.
    Molecular immunology, 2023, Volume: 153

    Topics: Animals; Humans; Inflammation; Lung; Mice; Mice, Inbred C57BL; Mucus; Pyroglyphidae

2023
Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation.
    Molecular immunology, 2023, Volume: 153

    Topics: Animals; Humans; Inflammation; Lung; Mice; Mice, Inbred C57BL; Mucus; Pyroglyphidae

2023
Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis.
    The Laryngoscope, 2023, Volume: 133, Issue:9

    Topics: Adenosine; Animals; Disease Models, Animal; Inflammation; Mice; Mucins; Mucus; Sinusitis

2023
Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress.
    Cell host & microbe, 2023, 03-08, Volume: 31, Issue:3

    Topics: Animals; Autophagy; Beclin-1; Goblet Cells; Inflammation; Intestinal Mucosa; Mice; Mucus

2023
Effects of Z-VaD-Ala-Asp-Fluoromethyl Ketone (Z-VAD-FMK) and Acetyl-Asp-Glu-Val-Asp-Aldehyde(Ac-DEVD-CHO) on Inflammation and Mucus Secretion in Mice Exposed to Cigarette Smoke.
    International journal of chronic obstructive pulmonary disease, 2023, Volume: 18

    Topics: Animals; Caspase 3; Cigarette Smoking; Inflammation; Interleukin-8; Male; Mice; Mice, Inbred C57BL;

2023
Foodborne Carbon Dot Exposure Induces Insulin Resistance through Gut Microbiota Dysbiosis and Damaged Intestinal Mucus Layer.
    ACS nano, 2023, 03-28, Volume: 17, Issue:6

    Topics: Animals; Bacteria; Dysbiosis; Gastrointestinal Microbiome; Inflammation; Insulin Resistance; Mammals

2023
LncRNA EPR regulates intestinal mucus production and protects against inflammation and tumorigenesis.
    Nucleic acids research, 2023, 06-09, Volume: 51, Issue:10

    Topics: Animals; Cell Transformation, Neoplastic; Colon; Disease Models, Animal; Humans; Inflammation; Intes

2023
Effects of Shiwei Longdanhua formula on LPS induced airway mucus hypersecretion, cough hypersensitivity, oxidative stress and pulmonary inflammation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 163

    Topics: Animals; Asthma; Chronic Disease; Cough; Hypersensitivity; Inflammation; Lipopolysaccharides; Mice;

2023
Autotaxin promotes the degradation of the mucus layer by inhibiting autophagy in mouse colitis.
    Molecular immunology, 2023, Volume: 160

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Colitis; Inflammation; Mice; Mucus

2023
Autophagy-ER stress crosstalk controls mucus secretion and susceptibility to gut inflammation.
    Autophagy, 2023, Volume: 19, Issue:11

    Topics: Animals; Autophagy; Beclin-1; Endoplasmic Reticulum Stress; Inflammation; Mice; Mucus; Nucleotides

2023
Formate oxidation in the intestinal mucus layer enhances fitness of
    mBio, 2023, 08-31, Volume: 14, Issue:4

    Topics: Animals; Bacteria; Formates; Inflammation; Lyases; Mice; Mucus; Pyruvates; Salmonella Infections, An

2023
Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway.
    Immunobiology, 2023, Volume: 228, Issue:5

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Humans; Hypersensitivity; Inf

2023
A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production.
    American journal of physiology. Lung cellular and molecular physiology, 2023, 12-01, Volume: 325, Issue:6

    Topics: Animals; Cytokines; Humans; Inflammation; Mitogen-Activated Protein Kinase 13; Mitogen-Activated Pro

2023
Industrialized human gut microbiota increases CD8+ T cells and mucus thickness in humanized mouse gut.
    Gut microbes, 2023, Volume: 15, Issue:2

    Topics: Animals; CD8-Positive T-Lymphocytes; Gastrointestinal Microbiome; Humans; Inflammation; Intestinal M

2023
Licorice flavonoid alleviates gastric ulcers by producing changes in gut microbiota and promoting mucus cell regeneration.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Dec-31, Volume: 169

    Topics: Animals; ErbB Receptors; Ethanol; Fatty Acids, Volatile; Gastrointestinal Microbiome; Glycyrrhiza; H

2023
Melia azedarach L. reduces pulmonary inflammation and mucus hypersecretion on a murine model of ovalbumin exposed asthma.
    Journal of ethnopharmacology, 2024, Feb-10, Volume: 320

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Inflammation; Meli

2024
Piperlongumine reduces ovalbumin‑induced asthma and airway inflammation by regulating nuclear factor‑κB activation.
    International journal of molecular medicine, 2019, Volume: 44, Issue:5

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Dioxolanes; Fibrosis; Humans; I

2019
Core 1-derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancer.
    The Journal of experimental medicine, 2020, 01-06, Volume: 217, Issue:1

    Topics: Animals; Antigens, Tumor-Associated, Carbohydrate; Carcinogenesis; Caspase 1; Female; Gastric Mucosa

2020
The abundance of Akkermansia muciniphila and its relationship with sulphated colonic mucins in health and ulcerative colitis.
    Scientific reports, 2019, 10-30, Volume: 9, Issue:1

    Topics: Adolescent; Adult; Akkermansia; Biopsy; Colitis, Ulcerative; Colon; Female; Healthy Volunteers; Huma

2019
4-Hydroxycinnamic acid suppresses airway inflammation and mucus hypersecretion in allergic asthma induced by ovalbumin challenge.
    Phytotherapy research : PTR, 2020, Volume: 34, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Coumaric Acids; Cyclooxygen

2020
Mucus Is a Key Factor in Neisseria meningitidis Commensalism.
    mSphere, 2019, 12-04, Volume: 4, Issue:6

    Topics: Epithelial Cells; Humans; Inflammation; Mucous Membrane; Mucus; Neisseria meningitidis; Symbiosis

2019
Effect of NF-κB signal pathway on mucus secretion induced by atmospheric PM
    Ecotoxicology and environmental safety, 2020, Mar-01, Volume: 190

    Topics: Air Pollutants; Animals; Asthma; Female; Inflammation; Lung; Male; Mucus; NF-kappa B; NF-KappaB Inhi

2020
Vagal sensory neurons drive mucous cell metaplasia.
    The Journal of allergy and clinical immunology, 2020, Volume: 145, Issue:6

    Topics: Animals; Female; Immunity, Innate; Inflammation; Lung; Male; Metaplasia; Mice; Mice, Inbred C57BL; M

2020
Getting neural about airway gland secretion.
    The European respiratory journal, 2020, Volume: 55, Issue:4

    Topics: Humans; Inflammation; Mucus; Neuropeptides; Respiratory System

2020
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
    Journal of ethnopharmacology, 2020, Jul-15, Volume: 257

    Topics: Animals; Bronchi; Cytokines; Drugs, Chinese Herbal; ErbB Receptors; Inflammation; Lung; Mucus; Phosp

2020
Mucus blocks probiotics but increases penetration of motile pathogens and induces TNF-α and IL-8 secretion.
    Biotechnology and bioengineering, 2020, Volume: 117, Issue:8

    Topics: Bacteria; HT29 Cells; Humans; Inflammation; Interleukin-8; Intestinal Mucosa; Models, Biological; Mu

2020
Warifteine and methylwarifteine inhibited the type 2 immune response on combined allergic rhinitis and asthma syndrome (CARAS) experimental model through NF-кB pathway.
    International immunopharmacology, 2020, Volume: 85

    Topics: Alkaloids; Animals; Anti-Allergic Agents; Asthma; Behavior, Animal; Bronchoalveolar Lavage Fluid; Ci

2020
Panax notoginseng saponin R1 modulates TNF-α/NF-κB signaling and attenuates allergic airway inflammation in asthma.
    International immunopharmacology, 2020, Volume: 88

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Disease Models, Ani

2020
Monocyte chemotactic protein-inducing protein 1 negatively regulating asthmatic airway inflammation and mucus hypersecretion involving γ-aminobutyric acid type A receptor signaling pathway in vivo and in vitro.
    Chinese medical journal, 2020, Sep-30, Volume: 134, Issue:1

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; gamma-Aminobutyric Acid; Inflammation; Mice; Mice, In

2020
Effect of Baicalin on Bacterial Secondary Infection and Inflammation Caused by H9N2 AIV Infection in Chickens.
    BioMed research international, 2020, Volume: 2020

    Topics: Animals; Antioxidants; Bacterial Infections; Bacterial Translocation; Chickens; Coinfection; Cytokin

2020
circARRDC3 contributes to interleukin‑13‑induced inflammatory cytokine and mucus production in nasal epithelial cells via the miR‑375/KLF4 axis.
    Molecular medicine reports, 2021, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Apoptosis; Arrestins; Cell Survival; Cells, Cultured; Chemokine CCL11; Cytokines;

2021
TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 134

    Topics: Acupuncture Therapy; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Anima

2021
Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice.
    Scientific reports, 2021, 02-11, Volume: 11, Issue:1

    Topics: Animals; Collagen; Dinoprostone; Ethanol; Gastric Mucosa; Glycoproteins; Inflammation; Interleukin-1

2021
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult
    Mediators of inflammation, 2021, Volume: 2021

    Topics: Animals; Cathepsins; Cystic Fibrosis; Disease Models, Animal; Epithelial Sodium Channels; Inflammati

2021
Time dependent impact of copper oxide nanomaterials on the expression of genes associated with oxidative stress, metal binding, inflammation and mucus secretion in single and co-culture intestinal in vitro models.
    Toxicology in vitro : an international journal published in association with BIBRA, 2021, Volume: 74

    Topics: Cell Line; Coculture Techniques; Copper; Copper Sulfate; Gene Expression Regulation; Heme Oxygenase-

2021
sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma.
    Immunological investigations, 2022, Volume: 51, Issue:5

    Topics: Animals; Asthma; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Glyco

2022
Mucociliary Clearance Differs in Mild Asthma by Levels of Type 2 Inflammation.
    Chest, 2021, Volume: 160, Issue:5

    Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoscopy; Cell Adhesion Molecules; Chemokine CCL26;

2021
Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis.
    Respiratory research, 2021, Jun-07, Volume: 22, Issue:1

    Topics: Aged; Biomarkers; Bronchitis, Chronic; Disease Progression; Drug Resistance; Female; Follow-Up Studi

2021
Atractylodin attenuates the expression of MUC5AC and extracellular matrix in lipopolysaccharide-induced airway inflammation by inhibiting the NF-κB pathway.
    Environmental toxicology, 2021, Volume: 36, Issue:9

    Topics: Animals; Extracellular Matrix; Furans; Humans; Inflammation; Lipopolysaccharides; Mice; Mucin 5AC; M

2021
Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.
    Scientific reports, 2021, 06-22, Volume: 11, Issue:1

    Topics: Animals; Autophagy; Autophagy-Related Proteins; Epithelial Cells; Female; Humans; Inflammation; Inte

2021
Epithelium-derived IL17A Promotes Cigarette Smoke-induced Inflammation and Mucus Hyperproduction.
    American journal of respiratory cell and molecular biology, 2021, Volume: 65, Issue:6

    Topics: Animals; Cell Line; Cigarette Smoking; Disease Models, Animal; Humans; Inflammation; Interleukin-17;

2021
17,18-Epoxyeicosatetraenoic Acid Inhibits TNF-α-Induced Inflammation in Cultured Human Airway Epithelium and LPS-Induced Murine Airway Inflammation.
    American journal of rhinology & allergy, 2022, Volume: 36, Issue:1

    Topics: Animals; Arachidonic Acids; Epithelium; Goblet Cells; Humans; Inflammation; Lipopolysaccharides; Mic

2022
Pathophysiology of Bronchiectasis.
    Seminars in respiratory and critical care medicine, 2021, Volume: 42, Issue:4

    Topics: Bronchiectasis; Humans; Inflammation; Mucociliary Clearance; Mucus; Persistent Infection

2021
Psoralen inhibits the inflammatory response and mucus production in allergic rhinitis by inhibiting the activator protein 1 pathway and the downstream expression of cystatin‑SN.
    Molecular medicine reports, 2021, Volume: 24, Issue:3

    Topics: Cell Line; Chemokine CCL11; Cytokines; Epithelial Cells; Ficusin; Granulocyte-Macrophage Colony-Stim

2021
Postnatal Ozone Exposure Disrupts Alveolar Development, Exaggerates Mucoinflammatory Responses, and Suppresses Bacterial Clearance in Developing
    Journal of immunology (Baltimore, Md. : 1950), 2021, 08-15, Volume: 207, Issue:4

    Topics: Animals; Bacteria; Cystic Fibrosis; Disease Models, Animal; Epithelial Sodium Channels; Inflammation

2021
Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease.
    International journal of molecular sciences, 2021, Jul-22, Volume: 22, Issue:15

    Topics: Animals; Anoctamin-1; Asthma; Constriction, Pathologic; Cystic Fibrosis; HEK293 Cells; Humans; Infla

2021
Identification of Mucus-Associated Molecular Subtypes of Chronic Obstructive Pulmonary Disease: A Latent Profile Analysis Based on MUC5B-Associated Genes.
    Medical science monitor : international medical journal of experimental and clinical research, 2021, Aug-14, Volume: 27

    Topics: Aged; Databases, Genetic; Female; Gene Expression; Genotype; Humans; Inflammation; Lung; Male; Mast

2021
Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice.
    Scientific reports, 2017, 04-11, Volume: 7

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flu

2017
Intradermal administration of IL-33 induces allergic airway inflammation.
    Scientific reports, 2017, 05-10, Volume: 7, Issue:1

    Topics: Animals; Antigens; Cytokines; Epitopes; Female; Hypersensitivity; Inflammation; Injections, Intrader

2017
Compositional Changes in the Gut Mucus Microbiota Precede the Onset of Colitis-Induced Inflammation.
    Inflammatory bowel diseases, 2017, Volume: 23, Issue:6

    Topics: Animals; Bacteria; Colitis; Colon; Disease Models, Animal; DNA, Bacterial; Dysbiosis; Feces; Gastroi

2017
Oxytetracycline Inhibits Mucus Secretion and Inflammation in Human Airway Epithelial Cells.
    Chemotherapy, 2017, Volume: 62, Issue:5

    Topics: Anti-Bacterial Agents; Cell Line; Down-Regulation; Epithelial Cells; Humans; Inflammation; Interleuk

2017
Effects of quinine on gastric ulcer healing in Wistar rats.
    Journal of complementary & integrative medicine, 2017, Jun-29, Volume: 14, Issue:4

    Topics: Acetic Acid; Animals; Cinchona; Gastric Mucosa; Inflammation; Lipid Peroxidation; Male; Mucus; Oxida

2017
Artemisia argyi attenuates airway inflammation in ovalbumin-induced asthmatic animals.
    Journal of ethnopharmacology, 2017, Sep-14, Volume: 209

    Topics: Animals; Artemisia; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Extracellular Signal-Regulated

2017
Inhaled simvastatin nanoparticles for inflammatory lung disease.
    Nanomedicine (London, England), 2017, Volume: 12, Issue:20

    Topics: Administration, Inhalation; Anti-Inflammatory Agents; Biological Transport; Chemistry, Pharmaceutica

2017
Fate of PEGylated antibody fragments following delivery to the lungs: Influence of delivery site, PEG size and lung inflammation.
    Journal of controlled release : official journal of the Controlled Release Society, 2018, 02-28, Volume: 272

    Topics: Administration, Inhalation; Animals; Cell Line, Tumor; Female; Humans; Immunoglobulin Fab Fragments;

2018
Oxygen matters: hypoxia as a pathogenic mechanism in rhinosinusitis.
    BMB reports, 2018, Volume: 51, Issue:2

    Topics: Epithelium; HMGB1 Protein; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation;

2018
Role of IL-13Rα2 in modulating IL-13-induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa.
    Allergy, 2018, Volume: 73, Issue:8

    Topics: Adolescent; Adult; Cells, Cultured; Dexamethasone; Female; Flavonoids; Glucocorticoids; Humans; Infl

2018
Accelerated gastric ulcer healing in thyroxine-treated rats: roles of gastric acid, mucus, and inflammatory response.
    Canadian journal of physiology and pharmacology, 2018, Volume: 96, Issue:6

    Topics: Animals; Cell Count; Gastric Acid; Histamine; Inflammation; Lymphocytes; Male; Mucus; Neutrophils; R

2018
Identification of clinically relevant chronic rhinosinusitis endotypes using cluster analysis of mucus cytokines.
    The Journal of allergy and clinical immunology, 2018, Volume: 141, Issue:5

    Topics: Adult; Chronic Disease; Cytokines; Female; Humans; Inflammation; Male; Middle Aged; Mucus; Nasal Pol

2018
Combined but not single administration of vitamin C and l-carnitine ameliorates cisplatin-induced gastric mucosa damage in male rats.
    Canadian journal of physiology and pharmacology, 2018, Volume: 96, Issue:8

    Topics: Animals; Antioxidants; Ascorbic Acid; Biomarkers; Body Weight; Carnitine; Cell Count; Cisplatin; Cyt

2018
Characterization of mucoid and serous middle ear effusions from patients with chronic otitis media: implication of different biological mechanisms?
    Pediatric research, 2018, Volume: 84, Issue:2

    Topics: Blood Proteins; Child; Child, Preschool; Chronic Disease; Complement System Proteins; DNA, Bacterial

2018
TRPC1 intensifies house dust mite-induced airway remodeling by facilitating epithelial-to-mesenchymal transition and STAT3/NF-κB signaling.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:1

    Topics: Airway Remodeling; Animals; Bronchi; Calcium; Collagen; Disease Models, Animal; Down-Regulation; Epi

2019
MicroRNA‑16 inhibits interleukin‑13‑induced inflammatory cytokine secretion and mucus production in nasal epithelial cells by suppressing the IκB kinase β/nuclear factor‑κB pathway.
    Molecular medicine reports, 2018, Volume: 18, Issue:4

    Topics: Base Sequence; Down-Regulation; Epithelial Cells; Humans; I-kappa B Kinase; Inflammation; Inflammati

2018
An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
    Science translational medicine, 2018, 08-22, Volume: 10, Issue:455

    Topics: Airway Remodeling; Airway Resistance; Animals; Asthma; Bronchi; Cell Count; Disease Models, Animal;

2018
Mucus protectors: Promising therapeutic strategies for inflammatory bowel disease.
    Medical hypotheses, 2018, Volume: 120

    Topics: Animals; Cytokines; Enzymes; Gastrointestinal Microbiome; Glycoside Hydrolases; Humans; Hydrogen-Ion

2018
Akkermansia muciniphila strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice.
    Gut microbes, 2019, Volume: 10, Issue:2

    Topics: Animals; Body Weight; Cecum; Disease Models, Animal; Escherichia coli; Gastrointestinal Microbiome;

2019
Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma.
    Chinese journal of integrative medicine, 2018, Volume: 24, Issue:12

    Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chemokines; Dis

2018
The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation.
    Cellular and molecular gastroenterology and hepatology, 2019, Volume: 7, Issue:2

    Topics: Animals; Cattle; Colitis; Diet; Disease Progression; Endoplasmic Reticulum Stress; Epithelial Cells;

2019
Increase in secreted airway mucins and partial Muc5b STAT6/FoxA2 regulation during Pneumocystis primary infection.
    Scientific reports, 2019, 02-14, Volume: 9, Issue:1

    Topics: Animals; Asthma; Epithelial Cells; Female; Hepatocyte Nuclear Factor 3-beta; Humans; Infant; Infant,

2019
Physalis peruviana L. inhibits ovalbumin‑induced airway inflammation by attenuating the activation of NF‑κB and inflammatory molecules.
    International journal of molecular medicine, 2019, Volume: 43, Issue:4

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Chemokine CCL2; Disease Models, Animal; Down-Regu

2019
Maltodextrin, Modern Stressor of the Intestinal Environment.
    Cellular and molecular gastroenterology and hepatology, 2019, Volume: 7, Issue:2

    Topics: Animals; Endoplasmic Reticulum Stress; Food Additives; Inflammation; Mucus; Polysaccharides

2019
The potential probiotic Lactobacillus rhamnosus CNCM I-3690 strain protects the intestinal barrier by stimulating both mucus production and cytoprotective response.
    Scientific reports, 2019, 04-01, Volume: 9, Issue:1

    Topics: Animals; Caco-2 Cells; Colon; Cytoprotection; Dinitrofluorobenzene; Gene Expression Profiling; Goble

2019
Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis.
    Science translational medicine, 2019, 04-03, Volume: 11, Issue:486

    Topics: Animals; Biomarkers; Case-Control Studies; Child; Child, Preschool; Cystic Fibrosis; Female; Humans;

2019
Rho-kinase inhibitor attenuates airway mucus hypersecretion and inflammation partly by downregulation of IL-13 and the JNK1/2-AP1 signaling pathway.
    Biochemical and biophysical research communications, 2019, 08-20, Volume: 516, Issue:2

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Down-Regulation; Female; Infl

2019
Food Polyelectrolytes Compress the Colonic Mucus Hydrogel by a Donnan Mechanism.
    Biomacromolecules, 2019, 07-08, Volume: 20, Issue:7

    Topics: Animals; Bacterial Infections; Biofilms; Carboxymethylcellulose Sodium; Colon; Disease Models, Anima

2019
Mucous hypersecretion and relationship to cough.
    Pulmonary pharmacology & therapeutics, 2013, Volume: 26, Issue:5

    Topics: Animals; Chronic Disease; Cough; Humans; Inflammation; Inhalation Exposure; Lung Diseases; Mucins; M

2013
Dendritic polyglycerolsulfate near infrared fluorescent (NIRF) dye conjugate for non-invasively monitoring of inflammation in an allergic asthma mouse model.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Animals; Asthma; Disease Models, Animal; Female; Fluorescent Dyes; Glycerol; Immunoglobulin G; Infla

2013
Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Airway Remodeling; Aldehyde Reductase; Animals; Asthma; Biomarkers; Chronic Disease; Disease Models,

2013
Pinellia ternata Breitenbach attenuates ovalbumin-induced allergic airway inflammation and mucus secretion in a murine model of asthma.
    Immunopharmacology and immunotoxicology, 2013, Volume: 35, Issue:3

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease

2013
Multiple dosing of simvastatin inhibits airway mucus production of epithelial cells: implications in the treatment of chronic obstructive airway pathologies.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2013, Volume: 84, Issue:3

    Topics: Cell Line; Cell Survival; Drug Administration Schedule; Drug Delivery Systems; Epithelial Cells; Hum

2013
Mucus and adiponectin deficiency: role in chronic inflammation-induced colon cancer.
    International journal of colorectal disease, 2013, Volume: 28, Issue:9

    Topics: Adiponectin; Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; bcl-2-Associated X Pr

2013
Anti-inflammatory, gastroprotective and anti-ulcerogenic effects of red algae Gracilaria changii (Gracilariales, Rhodophyta) extract.
    BMC complementary and alternative medicine, 2013, Mar-14, Volume: 13

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Betamethasone; Cell Line, Tumor; Chlorophyll;

2013
Hypertonic saline is effective in the prevention and treatment of mucus obstruction, but not airway inflammation, in mice with chronic obstructive lung disease.
    American journal of respiratory cell and molecular biology, 2013, Volume: 49, Issue:3

    Topics: Age Factors; Animals; Animals, Newborn; Chemotaxis; Disease Models, Animal; Epithelial Sodium Channe

2013
Dihydroartemisinin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model.
    Immunopharmacology and immunotoxicology, 2013, Volume: 35, Issue:3

    Topics: Animals; Anti-Asthmatic Agents; Artemisinins; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disea

2013
Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes.
    American journal of respiratory cell and molecular biology, 2013, Volume: 49, Issue:4

    Topics: Airway Remodeling; Allergens; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Female; Inflam

2013
Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.
    Science (New York, N.Y.), 2013, Oct-25, Volume: 342, Issue:6157

    Topics: Animals; beta Catenin; Cells, Cultured; Dendritic Cells; Galectin 3; Glycosylation; Homeostasis; Hum

2013
REG3γ-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum.
    Mucosal immunology, 2014, Volume: 7, Issue:4

    Topics: Animals; Disease Models, Animal; Gene Expression Profiling; Ileum; Immunity, Innate; Inflammation; I

2014
Naringenin inhibits allergen‑induced airway remodeling in a murine model of asthma.
    Molecular medicine reports, 2014, Volume: 9, Issue:4

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flu

2014
Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge.
    International journal of molecular medicine, 2014, Volume: 33, Issue:4

    Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Chemokine CC

2014
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease.
    American journal of respiratory and critical care medicine, 2014, May-01, Volume: 189, Issue:9

    Topics: Airway Obstruction; Animals; Bronchiectasis; Cystic Fibrosis; Disease Models, Animal; Epithelial Sod

2014
Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma.
    American journal of respiratory and critical care medicine, 2014, Apr-15, Volume: 189, Issue:8

    Topics: Asthma; Case-Control Studies; Cytokines; Disease Progression; Eosinophils; GPI-Linked Proteins; Huma

2014
Treatment with the C5a receptor/CD88 antagonist PMX205 reduces inflammation in a murine model of allergic asthma.
    International immunopharmacology, 2014, Volume: 21, Issue:2

    Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models,

2014
[Effects of inhaled LPS on inflammation and mucus hypersecretion in the airway of asthmatic mice].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2014, Volume: 45, Issue:3

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Inflammation; Interleukin-4; Lipopolysaccharides; Lun

2014
Usefulness of the assessment of discharge accumulation in the lower airways and tracheal septum thickening in the differential diagnosis of recurrent airway obstruction (RAO) and inflammatory airway disease (IAD) in the horse.
    Polish journal of veterinary sciences, 2014, Volume: 17, Issue:2

    Topics: Animals; Female; Horse Diseases; Horses; Inflammation; Male; Mucus; Pulmonary Disease, Chronic Obstr

2014
Regulation of nasal airway homeostasis and inflammation in mice by SHP-1 and Th2/Th1 signaling pathways.
    PloS one, 2014, Volume: 9, Issue:8

    Topics: Animals; Chemokines; Eosinophilia; Gelatin; Homeostasis; Inflammation; Interferon-gamma; Matrix Meta

2014
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
    Immunobiology, 2014, Volume: 219, Issue:12

    Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod

2014
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
    Immunobiology, 2014, Volume: 219, Issue:12

    Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod

2014
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
    Immunobiology, 2014, Volume: 219, Issue:12

    Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod

2014
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
    Immunobiology, 2014, Volume: 219, Issue:12

    Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod

2014
Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration.
    BMC genomics, 2014, Sep-10, Volume: 15

    Topics: Animals; Dehydration; Down-Regulation; Epithelial Sodium Channels; Gene Expression Profiling; Humans

2014
Nuclear erythroid 2 p45-related factor-2 Nrf2 ameliorates cigarette smoking-induced mucus overproduction in airway epithelium and mouse lungs.
    Microbes and infection, 2014, Volume: 16, Issue:10

    Topics: Animals; Cell Line, Tumor; Gene Expression Regulation; Humans; Inflammation; Lung; Mice; Mice, Inbre

2014
Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling.
    Journal of pineal research, 2015, Volume: 58, Issue:1

    Topics: Animals; Antioxidants; Cell Line, Tumor; Disease Models, Animal; Extracellular Signal-Regulated MAP

2015
Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.
    Respirology (Carlton, Vic.), 2015, Volume: 20, Issue:2

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Disease Models, Animal; Eosino

2015
Serotonin 5-HT₂ receptor activation prevents allergic asthma in a mouse model.
    American journal of physiology. Lung cellular and molecular physiology, 2015, Jan-15, Volume: 308, Issue:2

    Topics: 5-Hydroxytryptophan; Amphetamines; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactiv

2015
Lipoxin B₄ promotes the resolution of allergic inflammation in the upper and lower airways of mice.
    Mucosal immunology, 2015, Volume: 8, Issue:4

    Topics: Animals; Cell Degranulation; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Eosinophils;

2015
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.
    Nature communications, 2015, Feb-17, Volume: 6

    Topics: Allergens; Animals; Aspergillus oryzae; Asthma; Bronchial Hyperreactivity; Female; Immunohistochemis

2015
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.
    Nature communications, 2015, Feb-17, Volume: 6

    Topics: Allergens; Animals; Aspergillus oryzae; Asthma; Bronchial Hyperreactivity; Female; Immunohistochemis

2015
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.
    Nature communications, 2015, Feb-17, Volume: 6

    Topics: Allergens; Animals; Aspergillus oryzae; Asthma; Bronchial Hyperreactivity; Female; Immunohistochemis

2015
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.
    Nature communications, 2015, Feb-17, Volume: 6

    Topics: Allergens; Animals; Aspergillus oryzae; Asthma; Bronchial Hyperreactivity; Female; Immunohistochemis

2015
Model of mucociliary clearance in cystic fibrosis lungs.
    Journal of theoretical biology, 2015, May-07, Volume: 372

    Topics: Administration, Inhalation; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; De

2015
The sickle cell mouse lung: proinflammatory and primed for allergic inflammation.
    Translational research : the journal of laboratory and clinical medicine, 2015, Volume: 166, Issue:3

    Topics: Anemia, Sickle Cell; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytok

2015
Invariant Natural Killer T Cells Play a Role in Chemotaxis, Complement Activation and Mucus Production in a Mouse Model of Airway Hyperreactivity and Inflammation.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Acute-Phase Proteins; Animals; beta-N-Acetylhexosaminidases; Chemokines, CXC; Chemotaxis; Chitinase-

2015
SP600125 promotes resolution of allergic airway inflammation via TLR9 in an OVA-induced murine acute asthma model.
    Molecular immunology, 2015, Volume: 67, Issue:2 Pt B

    Topics: Acute Disease; Animals; Anthracenes; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Di

2015
Nanocomplexes for gene therapy of respiratory diseases: Targeting and overcoming the mucus barrier.
    Pulmonary pharmacology & therapeutics, 2015, Volume: 34

    Topics: Cystic Fibrosis; Expectorants; Gene Transfer Techniques; Genetic Therapy; Humans; Inflammation; Infl

2015
[Effects of ozone oxidative stress on the airway hyperresponsiveness and mucus production in mice with acute allergic airway inflammation].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2015, Volume: 38, Issue:3

    Topics: Animals; Asthma; Bronchoalveolar Lavage; Disease Models, Animal; Female; Inflammation; Interleukin-1

2015
Short-term exposure to formaldehyde promotes oxidative damage and inflammation in the trachea and diaphragm muscle of adult rats.
    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2015, Volume: 202

    Topics: Animals; Catalase; Diaphragm; Dose-Response Relationship, Drug; Environmental Pollutants; Formaldehy

2015
Copper oxide nanoparticles aggravate airway inflammation and mucus production in asthmatic mice via MAPK signaling.
    Nanotoxicology, 2016, Volume: 10, Issue:4

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Copper; Cytokines; Disease Models, Animal

2016
[Effect of Yifei Jianpi Recipe on Airway Inflammation and Airway Mucus Hypersecretion of Chronic Obstructive Pulmonary Disease Model Rats].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2015, Volume: 35, Issue:8

    Topics: Animals; Bronchi; Bronchoalveolar Lavage Fluid; Drugs, Chinese Herbal; Inflammation; Intercellular A

2015
Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice.
    Molecular medicine reports, 2016, Volume: 13, Issue:1

    Topics: Actins; Airway Remodeling; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Cell Count; Collagen; Fem

2016
Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium.
    Autophagy, 2016, Volume: 12, Issue:2

    Topics: Animals; Autophagy; Beclin-1; Bronchi; Cytokines; Endocytosis; Epithelial Cells; Epithelium; Humans;

2016
[Effects of simvastatin on airway inflammation and airway mucus hypersecretion in rats with chronic obstructive pulmonary disease].
    Zhonghua yi xue za zhi, 2015, Jun-09, Volume: 95, Issue:22

    Topics: Animals; Bronchi; Bronchoalveolar Lavage Fluid; Enzyme-Linked Immunosorbent Assay; Inflammation; Int

2015
[Effect of aminophylline and simvastatin on airway inflammation and mucus hypersecretion in rats with chronic obstructive pulmonary disease].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2016, Volume: 41, Issue:1

    Topics: Aminophylline; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Cytokines; Inflammation; Lipopolysacc

2016
Suhuang antitussive capsule at lower doses attenuates airway hyperresponsiveness, inflammation, and remodeling in a murine model of chronic asthma.
    Scientific reports, 2016, Feb-10, Volume: 6

    Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal;

2016
Enhanced pulmonary delivery of fluticasone propionate in rodents by mucus-penetrating nanoparticles.
    International journal of pharmaceutics, 2016, Apr-11, Volume: 502, Issue:1-2

    Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Delayed-Action Preparations; Drug Del

2016
Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice.
    American journal of respiratory cell and molecular biology, 2016, Volume: 55, Issue:2

    Topics: Adrenergic beta-2 Receptor Agonists; Aminopyridines; Animals; Asthma; Benzamides; Bronchial Hyperrea

2016
Association of tracheal mucus or blood and airway neutrophilia with racing performance in Thoroughbred horses in an Australian racing yard.
    Australian veterinary journal, 2016, Volume: 94, Issue:4

    Topics: Animals; Blood; Bronchoalveolar Lavage Fluid; Bronchoscopy; Hemorrhage; Horse Diseases; Horses; Infl

2016
High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22.
    Scientific reports, 2016, 06-28, Volume: 6

    Topics: Animals; Cells, Cultured; Colon; Cytokines; Diet, High-Fat; Epithelial Cells; Inflammation; Interleu

2016
Transcriptomic profiling revealed the signatures of intestinal barrier alteration and pathogen entry in turbot (Scophthalmus maximus) following Vibrio anguillarum challenge.
    Developmental and comparative immunology, 2016, Volume: 65

    Topics: Animals; Antioxidants; Apoptosis; Bacterial Adhesion; Cells, Cultured; Flatfishes; Immunity, Mucosal

2016
The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation.
    Clinics (Sao Paulo, Brazil), 2016, Volume: 71, Issue:6

    Topics: Adult; Carbon Monoxide; Cell Count; Cotinine; Female; Humans; Inflammation; Interleukin-6; Interleuk

2016
Silibinin Inhibits Neutrophilic Inflammation and Mucus Secretion Induced by Cigarette Smoke via Suppression of ERK-SP1 Pathway.
    Phytotherapy research : PTR, 2016, Volume: 30, Issue:12

    Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Inflammation; Male; Mice; Mice, Inbred C57BL; M

2016
Cold-inducible RNA-binding protein mediates airway inflammation and mucus hypersecretion through a post-transcriptional regulatory mechanism under cold stress.
    The international journal of biochemistry & cell biology, 2016, Volume: 78

    Topics: 3' Untranslated Regions; Aged; Animals; Bronchitis; Cold-Shock Response; Cytokines; Female; Gene Exp

2016
Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.
    Science translational medicine, 2016, 10-05, Volume: 8, Issue:359

    Topics: Adult; Allergens; Asthma; Cytokines; Humans; Hypersensitivity; Inflammation; Lung; Mucus; Muscle, Sm

2016
Fish gut-liver immunity during homeostasis or inflammation revealed by integrative transcriptome and proteome studies.
    Scientific reports, 2016, 11-03, Volume: 6

    Topics: Animals; Bile; Fishes; Gastrointestinal Tract; Gene Expression Regulation; Gene Library; Gene Ontolo

2016
Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.
    American journal of respiratory cell and molecular biology, 2008, Volume: 39, Issue:6

    Topics: Allergens; Animals; Bronchoalveolar Lavage Fluid; Cell Count; Gene Expression Regulation; Immunizati

2008
CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling.
    The Journal of allergy and clinical immunology, 2008, Volume: 122, Issue:3

    Topics: Adoptive Transfer; Allergens; Animals; Asthma; Cell Separation; Collagen; Eosinophils; Female; Immun

2008
Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans.
    The American journal of pathology, 2008, Volume: 173, Issue:4

    Topics: Adult; Animals; Down-Regulation; Dual Oxidases; Enzyme Induction; Female; Heme Oxygenase-1; Hemin; H

2008
Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products.
    European journal of immunology, 2009, Volume: 39, Issue:3

    Topics: Animals; Antigens, Fungal; Aspergillus fumigatus; Bacteria; Candida albicans; Cell Extracts; Cytokin

2009
Different doses of lipopolysaccharides regulate the lung inflammation of asthmatic mice via TLR4 pathway in alveolar macrophages.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2009, Volume: 46, Issue:3

    Topics: Animals; Asthma; Dose-Response Relationship, Drug; Eosinophils; Female; Inflammation; Interferon-gam

2009
IL-6 is required for airway mucus production induced by inhaled fungal allergens.
    Journal of immunology (Baltimore, Md. : 1950), 2009, Aug-01, Volume: 183, Issue:3

    Topics: Allergens; Animals; Antigens, Fungal; Aspergillus fumigatus; Epithelial Cells; Hypersensitivity; Inf

2009
Candida soluble cell wall beta-glucan facilitates ovalbumin-induced allergic airway inflammation in mice: Possible role of antigen-presenting cells.
    Respiratory research, 2009, Jul-21, Volume: 10

    Topics: Animals; Antigen-Presenting Cells; beta-Glucans; Bronchoalveolar Lavage Fluid; Candida albicans; Cel

2009
Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling.
    Journal of immunology (Baltimore, Md. : 1950), 2009, Oct-15, Volume: 183, Issue:8

    Topics: Allergens; Animals; Antibodies, Monoclonal; Antigens, Differentiation, Myelomonocytic; Apoptosis; Eo

2009
Anti-inflammatory and anti-asthmatic effects of Viola mandshurica W. Becker (VM) ethanolic (EtOH) extract on airway inflammation in a mouse model of allergic asthma.
    Journal of ethnopharmacology, 2010, Jan-08, Volume: 127, Issue:1

    Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchi; Bronchial

2010
Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:3

    Topics: Animals; Benzylamines; Cell Line; Cell Movement; Female; Guinea Pigs; Humans; In Vitro Techniques; I

2010
Helminth infection inhibits airway allergic reaction and dendritic cells are involved in the modulation process.
    Parasite immunology, 2010, Volume: 32, Issue:1

    Topics: Adoptive Transfer; Animals; Asthma; Bronchial Hyperreactivity; Dendritic Cells; Eosinophilia; Female

2010
The plant extract Isatis tinctoria L. extract (ITE) inhibits allergen-induced airway inflammation and hyperreactivity in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Volume: 17, Issue:8-9

    Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lav

2010
Pathology of gastrointestinal organs in a porcine model of cystic fibrosis.
    The American journal of pathology, 2010, Volume: 176, Issue:3

    Topics: Animals; Cell Proliferation; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; D

2010
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.
    Science translational medicine, 2010, Apr-28, Volume: 2, Issue:29

    Topics: Animals; Animals, Newborn; Cystic Fibrosis; Disease Models, Animal; Ileus; Inflammation; Lung; Mecon

2010
Neurotoxic, inflammatory, and mucosecretory responses in the nasal airways of mice repeatedly exposed to the macrocyclic trichothecene mycotoxin roridin A: dose-response and persistence of injury.
    Toxicologic pathology, 2010, Volume: 38, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Female; Immunohistochemistry; Inflammation; Macrocyclic C

2010
Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice.
    Journal of cellular and molecular medicine, 2011, Volume: 15, Issue:6

    Topics: Animals; Antigens; Aquaporin 5; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Gene Deletion; Hype

2011
Anti-inflammatory effects of ethanolic extract from Lagerstroemia indica on airway inflammation in mice.
    Journal of ethnopharmacology, 2011, Jul-14, Volume: 136, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Eosin

2011
Repeated stress reduces mucociliary clearance in animals with chronic allergic airway inflammation.
    Respiratory physiology & neurobiology, 2010, Aug-31, Volume: 173, Issue:1

    Topics: Adrenal Glands; Animals; Bronchial Hyperreactivity; Cilia; Disease Models, Animal; Epithalamus; Guin

2010
Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-κB inhibition.
    Journal of ethnopharmacology, 2011, Jul-14, Volume: 136, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Biological Transport; Bronchoalveolar Lavage Fluid; Cell

2011
Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation.
    Journal of immunology (Baltimore, Md. : 1950), 2010, Sep-01, Volume: 185, Issue:5

    Topics: Acute Disease; Allergens; Animals; Cells, Cultured; Chickens; Eosinophilia; Gene Deletion; Inflammat

2010
Cystic fibrosis: deciphering the complexity.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2010, Volume: 16, Issue:7

    Topics: Bacterial Infections; Candida albicans; Chromosomes, Human, Pair 7; Cystic Fibrosis; Cystic Fibrosis

2010
Effects of astragaloside IV on IFN-gamma level and prolonged airway dysfunction in a murine model of chronic asthma.
    Planta medica, 2011, Volume: 77, Issue:4

    Topics: Animals; Asthma; Astragalus Plant; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chronic

2011
An alternate method of classifying allergic bronchopulmonary aspergillosis based on high-attenuation mucus.
    PloS one, 2010, Dec-15, Volume: 5, Issue:12

    Topics: Adult; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Female; Humans; Inflammation

2010
Inhibition of airway inflammation, hyperresponsiveness and remodeling by soy isoflavone in a murine model of allergic asthma.
    International immunopharmacology, 2011, Volume: 11, Issue:8

    Topics: Airway Remodeling; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chemoki

2011
Studies on pharmacological properties of mucus and sting venom of Potamotrygon cf. henlei.
    International immunopharmacology, 2011, Volume: 11, Issue:9

    Topics: Animals; Anti-Infective Agents; Bacteria; Brazil; Edema; Elasmobranchii; Female; Fish Venoms; Fishes

2011
Descriptive results from a longitudinal study of airway inflammation in British National Hunt racehorses.
    Equine veterinary journal, 2011, Volume: 43, Issue:6

    Topics: Aging; Animals; Horse Diseases; Horses; Inflammation; Longitudinal Studies; Mucus; Neutrophils; Odds

2011
Introduction to section I: overview of approaches to study cystic fibrosis pathophysiology.
    Methods in molecular biology (Clifton, N.J.), 2011, Volume: 742

    Topics: Airway Remodeling; Animals; Bacterial Infections; Biofilms; Biological Transport; Cystic Fibrosis; C

2011
Muc5b is the major polymeric mucin in mucus from thoroughbred horses with and without airway mucus accumulation.
    PloS one, 2011, Volume: 6, Issue:5

    Topics: Airway Obstruction; Animals; Antibodies; Bacteria; Horse Diseases; Horses; Immune Sera; Inflammation

2011
Flow cytometry of sputum: assessing inflammation and immune response elements in the bronchial airways.
    Inhalation toxicology, 2011, Volume: 23, Issue:7

    Topics: Asthma; B-Lymphocytes; Biomarkers; Bronchi; Dendritic Cells; Eosinophils; Epithelial Cells; Flow Cyt

2011
Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor.
    The Journal of biological chemistry, 2011, Aug-12, Volume: 286, Issue:32

    Topics: Allergens; Animals; Asthma; Disease Models, Animal; Enzyme Inhibitors; Gene Knock-In Techniques; Gro

2011
IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease.
    The American journal of pathology, 2011, Volume: 179, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Blotting, Western; CD8-Positive T-Lymphocytes; Disease Models, Anim

2011
Anterior cruciate ligament changes in the human knee joint in aging and osteoarthritis.
    Arthritis and rheumatism, 2012, Volume: 64, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Anterior Cruciate Ligament; Cartilage; Female; Humans; Inflam

2012
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals.
    Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2

    Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An

2012
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals.
    Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2

    Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An

2012
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals.
    Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2

    Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An

2012
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals.
    Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2

    Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An

2012
Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.
    European journal of pharmacology, 2012, Mar-15, Volume: 679, Issue:1-3

    Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Adhesion Molecules; Cell Coun

2012
Prior exercise training alleviates the lung inflammation induced by subsequent exposure to environmental cigarette smoke.
    Acta physiologica (Oxford, England), 2012, Volume: 205, Issue:4

    Topics: Animals; Bronchoalveolar Lavage Fluid; Inflammation; Lung Diseases; Mice; Mucus; Physical Conditioni

2012
Modulation of lung allergic response by renal ischemia and reperfusion injury.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012, Volume: 29, Issue:3-4

    Topics: Animals; Blood Cell Count; Bronchoalveolar Lavage Fluid; Creatinine; Cyclooxygenase 2; Hypersensitiv

2012
Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis.
    Disease models & mechanisms, 2012, Volume: 5, Issue:4

    Topics: Animals; Dextran Sulfate; Disease Models, Animal; Enterocolitis; Inflammation; Intestinal Mucosa; In

2012
In vivo determination of mouse olfactory mucus cation concentrations in normal and inflammatory states.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Adult; Allergens; Animals; Cations; Disease Models, Animal; Eosinophil Major Basic Protein; Eosinoph

2012
The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunoglobulin E;

2012
Long-lived Th2 memory in experimental allergic asthma.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Nov-01, Volume: 169, Issue:9

    Topics: Acute Disease; Aerosols; Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Female; Immunoglobul

2002
A small molecule inhibitor of redox-regulated NF-kappa B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Nov-01, Volume: 169, Issue:9

    Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar L

2002
IgE cross-linking or lipopolysaccharide treatment induces recruitment of Th2 cells to the lung in the absence of specific antigen.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Nov-15, Volume: 169, Issue:10

    Topics: Adjuvants, Immunologic; Administration, Intranasal; Animals; Antigens, Differentiation, T-Lymphocyte

2002
Bax is crucial for IFN-gamma-induced resolution of allergen-induced mucus cell metaplasia.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Nov-15, Volume: 169, Issue:10

    Topics: Allergens; Animals; bcl-2-Associated X Protein; Bronchi; Cell Count; Culture Techniques; Dissection;

2002
Mucus hypersecretion in respiratory disease. Chair's introduction.
    Novartis Foundation symposium, 2002, Volume: 248

    Topics: Animals; Asthma; Chloride Channels; Exocytosis; Humans; Inflammation; Lymphokines; Mice; Mucus; Pulm

2002
Chronic diesel exhaust exposures of rats demonstrate concentration and time-dependent effects on pulmonary inflammation.
    Inhalation toxicology, 2003, Apr-25, Volume: 15, Issue:5

    Topics: Animals; Bronchoalveolar Lavage Fluid; Dinoprostone; Inflammation; Lung; Male; Mucus; Pulmonary Dise

2003
Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses asthma-like responses via nitric oxide synthase 2 activity.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Jul-15, Volume: 171, Issue:2

    Topics: Administration, Inhalation; Allergens; Animals; Anti-Allergic Agents; Asthma; Bronchi; Bronchial Hyp

2003
Airway inflammation and mucus in two age groups of asymptomatic well-performing sport horses.
    Equine veterinary journal, 2003, Volume: 35, Issue:5

    Topics: Age Factors; Animals; Bronchoalveolar Lavage Fluid; Female; Flow Cytometry; Horse Diseases; Horses;

2003
[INFLAMMATION OF THE APPENDIX ON THE BASIS OF THE STAGNATION THEORY. (EXPERIMENTAL STUDY)].
    Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 1964, Volume: 43

    Topics: Acute Disease; Animals; Appendicitis; Appendix; Inflammation; Mucous Membrane; Mucus; Rabbits; Resea

1964
Breath condensate hydrogen peroxide correlates with both airway cytology and epithelial lining fluid ascorbic acid concentration in the horse.
    Free radical research, 2004, Volume: 38, Issue:2

    Topics: Airway Obstruction; Animals; Ascorbic Acid; Breath Tests; Bronchoalveolar Lavage Fluid; Bronchoscopy

2004
Mucus hypersecretion: a common symptom, a common mechanism?
    The European respiratory journal, 2004, Volume: 23, Issue:6

    Topics: Asthma; Chloride Channels; Cystic Fibrosis; Humans; Inflammation; Interleukin-9; Mucus; Receptors, I

2004
A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice.
    Journal of immunology (Baltimore, Md. : 1950), 2004, Jul-15, Volume: 173, Issue:2

    Topics: Adenosine Deaminase; Animals; Eosinophils; Inflammation; Mice; Mice, Knockout; Mucus; Receptor, Aden

2004
NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness.
    Journal of immunology (Baltimore, Md. : 1950), 2004, Dec-01, Volume: 173, Issue:11

    Topics: Allergens; Animals; Antibody Specificity; Bronchial Hyperreactivity; Chemokines; Cytokines; I-kappa

2004
Endoscopic scoring of mucus quantity and quality: observer and horse variance and relationship to inflammation, mucus viscoelasticity and volume.
    Equine veterinary journal, 2004, Volume: 36, Issue:7

    Topics: Animals; Endoscopy; Horse Diseases; Horses; Inflammation; Mucus; Observer Variation; Pigmentation; R

2004
Reduced expression of transforming growth factor beta 1 exacerbates pathology in an experimental asthma model.
    European journal of immunology, 2005, Volume: 35, Issue:1

    Topics: Animals; Asthma; Cytokines; Disease Models, Animal; Female; Heterozygote; Immunization; Immunoglobul

2005
A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury.
    The Journal of clinical investigation, 2005, Volume: 115, Issue:1

    Topics: Adenosine; Adenosine Deaminase; Animals; Chemokines; Cytokines; Inflammation; Lung; Lung Injury; Met

2005
Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway.
    Journal of immunology (Baltimore, Md. : 1950), 2005, May-01, Volume: 174, Issue:9

    Topics: Allergens; Animals; Bronchoalveolar Lavage Fluid; Cell Proliferation; DNA-Binding Proteins; Down-Reg

2005
Inflammatory airway disease, nasal discharge and respiratory infections in young British racehorses.
    Equine veterinary journal, 2005, Volume: 37, Issue:3

    Topics: Age Factors; Animals; Bacterial Infections; Female; Horse Diseases; Horses; Incidence; Inflammation;

2005
Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10.
    BMC genetics, 2005, May-27, Volume: 6

    Topics: Animals; Body Weight; Chromosomes, Mammalian; Cystic Fibrosis; Female; Genetic Markers; Inflammation

2005
Characteristic features of allergic airway inflammation in a murine model of infantile asthma.
    International archives of allergy and immunology, 2005, Volume: 138, Issue:1

    Topics: Age Factors; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Di

2005
Anti-T-cell Ig and mucin domain-containing protein 1 antibody decreases TH2 airway inflammation in a mouse model of asthma.
    The Journal of allergy and clinical immunology, 2005, Volume: 116, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Asthma; Cytokines; Disease Models, Animal; Female; Hepatitis A Viru

2005
Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness.
    International immunology, 2006, Volume: 18, Issue:6

    Topics: Animals; Asthma; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Embryo, Mammalian; Eosinop

2006
Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Jul-18, Volume: 103, Issue:29

    Topics: Alcohol Dehydrogenase; Animals; Asthma; Dendritic Cells; Exocrine Glands; Glutathione Reductase; Inf

2006
Airway inflammation in Michigan pleasure horses: prevalence and risk factors.
    Equine veterinary journal, 2006, Volume: 38, Issue:4

    Topics: Age Factors; Analysis of Variance; Animal Feed; Animals; Bronchoalveolar Lavage Fluid; Female; Horse

2006
The prevalence of laryngeal disease in a large population of competition draft horses.
    Veterinary surgery : VS, 2006, Volume: 35, Issue:6

    Topics: Animals; Breeding; Cross-Sectional Studies; Endoscopy, Digestive System; Female; Horse Diseases; Hor

2006
ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice.
    Molecular and cellular biology, 2006, Volume: 26, Issue:18

    Topics: ADAM Proteins; Allergens; Animals; Asthma; Breeding; Bronchial Hyperreactivity; Female; Gene Targeti

2006
A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Oct-31, Volume: 103, Issue:44

    Topics: Allergens; Animals; Bronchial Hyperreactivity; Cell Movement; Chemokine CCL11; Chemokines, CC; Chron

2006
Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling.
    The American journal of pathology, 2006, Volume: 169, Issue:6

    Topics: Animals; Asthma; Chemokine CCL11; Chemokines, CC; Collagen; Eosinophils; Inflammation; Interleukin-1

2006
Endoscopic scoring of the tracheal septum in horses and its clinical relevance for the evaluation of lower airway health in horses.
    Equine veterinary journal, 2007, Volume: 39, Issue:2

    Topics: Age Factors; Animals; Endoscopy; Horse Diseases; Horses; Inflammation; Mucus; Observer Variation; Re

2007
Plasminogen is an important regulator in the pathogenesis of a murine model of asthma.
    American journal of respiratory and critical care medicine, 2007, Aug-15, Volume: 176, Issue:4

    Topics: Animals; Antifibrinolytic Agents; Asthma; Bronchoalveolar Lavage Fluid; Collagen; Disease Models, An

2007
Effects of laxative and N-acetylcysteine on mucus accumulation, bacterial load, transit, and inflammation in the cystic fibrosis mouse small intestine.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 293, Issue:3

    Topics: Acetylcysteine; Animals; Bacteria; Body Weight; Cathartics; Cystic Fibrosis; Disease Models, Animal;

2007
LPS-induced mucin expression in human sinus mucosa can be attenuated by hCLCA inhibitors.
    Journal of endotoxin research, 2007, Volume: 13, Issue:2

    Topics: Adult; Cell Line; Chloride Channels; Female; Flow Cytometry; Gene Expression Regulation; Humans; Imm

2007
Airway inflammation in COPD: friend or foe?
    American journal of respiratory and critical care medicine, 2007, Sep-01, Volume: 176, Issue:5

    Topics: Anti-Inflammatory Agents; Disease Progression; Humans; Immunity; Inflammation; Mucus; Pulmonary Dise

2007
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Nov-15, Volume: 179, Issue:10

    Topics: Adenoviridae; Animals; Apoptosis; Caspases; Heterocyclic Compounds, 3-Ring; I-kappa B Kinase; Inflam

2007
Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation.
    Nature medicine, 2008, Volume: 14, Issue:2

    Topics: Animals; Antibody Formation; Bronchial Hyperreactivity; Chemokines; Chemotactic Factors; Dendritic C

2008
Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2008, Volume: 38, Issue:5

    Topics: Allergens; Animals; Cytokines; Disease Models, Animal; Inflammation; Isoquinolines; Lung; Mice; Mice

2008
Experimental production of rabbit mucoid enteritis.
    American journal of veterinary research, 1983, Volume: 44, Issue:4

    Topics: Animals; Cecum; Cholestyramine Resin; Colon; Constipation; Enteritis; Escherichia coli; Inflammation

1983
The vulvar vestibule.
    The Journal of reproductive medicine, 1983, Volume: 28, Issue:11

    Topics: Condylomata Acuminata; Cysts; Exocrine Glands; Female; Humans; Inflammation; Mucus; Sebaceous Glands

1983
Polymucositis: a cause of Ga-67 uptake.
    Clinical nuclear medicine, 1981, Volume: 6, Issue:3

    Topics: Child; Diagnosis, Differential; Doxorubicin; Esophagus; Gallium Radioisotopes; Gastrointestinal Dise

1981
A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically.
    British journal of pharmacology, 1993, Volume: 109, Issue:1

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Capsaicin; Elec

1993
The role of 16,16-dimethyl prostaglandin E2 on the intrahepatic biliary branches in dogs.
    Hepatology (Baltimore, Md.), 1993, Volume: 17, Issue:6

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Bacteroides Infections; Bile Ducts, Intrahepatic; Cholestas

1993
Evaluation of cecal ligation as a model of mucoid enteropathy in specific-pathogen-free rabbits.
    Laboratory animal science, 1996, Volume: 46, Issue:2

    Topics: Animals; Cecal Diseases; Cecum; Colon; Disease Models, Animal; Inflammation; Intestinal Diseases; Li

1996
Effects of water pollution on the gill apparatus of fish.
    Journal of comparative pathology, 1996, Volume: 115, Issue:1

    Topics: Animals; Female; Gills; Histocytochemistry; Inflammation; Male; Mucus; Rheology; Tilapia; Water Poll

1996
The importance of leukotrienes in airway inflammation in a mouse model of asthma.
    The Journal of experimental medicine, 1996, Oct-01, Volume: 184, Issue:4

    Topics: 5-Lipoxygenase-Activating Proteins; Allergens; Animals; Asthma; Bronchial Provocation Tests; Broncho

1996
Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production.
    The Journal of experimental medicine, 1997, Nov-17, Volume: 186, Issue:10

    Topics: Adoptive Transfer; Animals; Bronchi; Cell Movement; Epitopes; Inflammation; Interleukin-4; Lung; Lym

1997
Inflammation and a thickened mucus layer in mice with cholesterol gallstones.
    The Journal of surgical research, 1998, Volume: 74, Issue:1

    Topics: Animals; Cholecystitis; Cholelithiasis; Cholesterol; Cholesterol, Dietary; Cholic Acid; Cholic Acids

1998
Effects of neurotransmitters, gut hormones, and inflammatory mediators on mucus discharge in rat colon.
    The American journal of physiology, 1998, Volume: 275, Issue:5

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Atropine; Bethanechol; Bombesin; Calcitonin Gene-Related Pe

1998
Secretory leukocyte protease inhibitor prevents allergen-induced pulmonary responses in animal models of asthma.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Aerosols; Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoconst

1999
Pharmacokinetics of enrofloxacin and danofloxacin in plasma, inflammatory exudate, and bronchial secretions of calves following subcutaneous administration.
    Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:8

    Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Bronchi; Cattle; Chromatography, High Pressur

1999
T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production.
    The Journal of experimental medicine, 1999, Nov-01, Volume: 190, Issue:9

    Topics: Animals; Asthma; Disease Models, Animal; Eosinophilia; Flow Cytometry; Hypersensitivity; Inflammatio

1999
Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.
    Immunity, 1999, Volume: 11, Issue:4

    Topics: Aerosols; Amino Acid Substitution; Animals; Asthma; Bronchoalveolar Lavage Fluid; DNA-Binding Protei

1999
In vivo interactions of rabbit enteropathogenic Escherichia coli O103 with its host: an electron microscopic and histopathologic study.
    Microbes and infection, 2000, Volume: 2, Issue:1

    Topics: Animals; Cecum; Colon; Escherichia coli; Escherichia coli Infections; Feces; Female; Ileum; Inflamma

2000
Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Apr-24, Volume: 98, Issue:9

    Topics: Animals; Asthma; Cell Line; Chloride Channels; Cloning, Molecular; Disease Models, Animal; Epitheliu

2001
Differential properties of mucous glycoproteins in rat nasal epithelium. A comparison between allergic inflammation and lipopolysaccharide stimulation.
    American journal of respiratory and critical care medicine, 2001, Sep-15, Volume: 164, Issue:6

    Topics: Animals; Data Interpretation, Statistical; Epithelium; Goblet Cells; Histocytochemistry; Hypersensit

2001
Exposure to diesel exhaust exacerbates allergen-induced airway responses in guinea pigs.
    American journal of respiratory and critical care medicine, 2001, Nov-15, Volume: 164, Issue:10 Pt 1

    Topics: Allergens; Analysis of Variance; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavag

2001
Interleukin-4 and interleukin-5 gene expression and inflammation in the mucus-secreting glands and subepithelial tissue of smokers with chronic bronchitis. Lack of relationship with CD8(+) cells.
    American journal of respiratory and critical care medicine, 2001, Dec-15, Volume: 164, Issue:12

    Topics: Aged; Aged, 80 and over; Bronchi; Bronchitis, Chronic; CD8-Positive T-Lymphocytes; Epithelium; Exocr

2001
Granulocyte depletion and dexamethasone differentially modulate airways hyperreactivity, inflammation, mucus accumulation, and secretion induced by rmIL-13 or antigen.
    American journal of respiratory cell and molecular biology, 2002, Volume: 26, Issue:1

    Topics: Animals; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Dexamethasone; Dose-Respo

2002
Tryptase inhibition blocks airway inflammation in a mouse asthma model.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Feb-15, Volume: 168, Issue:4

    Topics: Animals; Asthma; Bridged Bicyclo Compounds, Heterocyclic; Bronchial Diseases; Bronchial Hyperreactiv

2002
IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Mar-15, Volume: 168, Issue:6

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemokine CCL2; Chemokines, CC; Endopeptidas

2002
Pulmonary inflammation monitored noninvasively by MRI in freely breathing rats.
    Biochemical and biophysical research communications, 2002, Mar-22, Volume: 292, Issue:1

    Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Budesonide; Eosi

2002
Inflammatory responses and mucus secretion in rats with acute bronchiolitis induced by nickel chloride.
    Inhalation toxicology, 2002, Volume: 14, Issue:4

    Topics: Animals; Bronchiolitis; Disease Models, Animal; Inflammation; Inhalation Exposure; Male; Mucus; Nick

2002
The effects of fusidic acid on the inflammatory response in rats.
    Pharmacological research, 2002, Volume: 45, Issue:4

    Topics: Animals; Blood Cell Count; Edema; Foot; Formaldehyde; Fusidic Acid; Gastric Mucosa; Inflammation; Ma

2002
New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Jul-01, Volume: 169, Issue:1

    Topics: Adenoviridae; Administration, Intranasal; Amino Acid Motifs; Amino Acid Sequence; Animals; Aspergill

2002
Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Jul-15, Volume: 169, Issue:2

    Topics: Adoptive Transfer; Aerosols; Animals; Bronchoalveolar Lavage Fluid; Cell Migration Inhibition; Cell

2002
[The small airways obstruction: an assay of structure-function correlation].
    Le Poumon et le coeur, 1975, Volume: 31, Issue:5

    Topics: Bronchi; Emphysema; Epithelium; Humans; Inflammation; Lung Diseases, Obstructive; Mucus; Respiratory

1975
Pathological observations of intrahepatic peribiliary glands in 1,000 consecutive autopsy livers. III. Survey of necroinflammation and cystic dilatation.
    Hepatology (Baltimore, Md.), 1990, Volume: 12, Issue:5

    Topics: Bile Duct Diseases; Bile Ducts, Intrahepatic; Cysts; Humans; Inflammation; Liver; Mucus; Necrosis; S

1990
Role of enzymes from inflammatory cells on airway submucosal gland secretion.
    Respiration; international review of thoracic diseases, 1991, Volume: 58 Suppl 1

    Topics: Animals; Cathepsin G; Cathepsins; Cattle; Cells, Cultured; Chymases; Exocrine Glands; Inflammation;

1991
The histological patterns of normal and inflamed middle ear mucosa.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 1991, Volume: 248, Issue:3

    Topics: Child, Preschool; Exocrine Glands; Humans; Infant; Infant, Newborn; Inflammation; Mucus; Otitis Medi

1991
Immunological suppression of delayed hypersensitivity responses in mouse lungs as reflected by numbers of mononuclear cells, mast cells and mucus-producing cells.
    International archives of allergy and applied immunology, 1988, Volume: 85, Issue:1

    Topics: Animals; Cell Count; Female; Hypersensitivity, Delayed; Immunosuppressive Agents; Inflammation; Leuk

1988
In vivo effects of transient neutrophil influx on nasal respiratory epithelial mucosubstances. Quantitative histochemistry.
    The American journal of pathology, 1988, Volume: 130, Issue:3

    Topics: Animals; Cell Movement; Endotoxins; Epithelium; Female; Inflammation; Lung; Mucus; Nasal Mucosa; Neu

1988
Evidence favouring PAF rather than leukotrienes in the pathogenesis of asthma.
    Pharmacological research communications, 1986, Volume: 18 Suppl

    Topics: Asthma; Bronchi; Eosinophils; Humans; Inflammation; Mucus; Platelet Activating Factor; Respiratory S

1986
15-Hydroxyeicosatetraenoic acid is a potent inflammatory mediator and agonist of canine tracheal mucus secretion.
    The American review of respiratory disease, 1985, Volume: 131, Issue:6

    Topics: Aerosols; Animals; Arachidonic Acid; Arachidonic Acids; Body Fluids; Cell Movement; Chemotaxis; Dogs

1985
Bronchography in childhood asthma.
    The American journal of roentgenology, radium therapy, and nuclear medicine, 1972, Volume: 116, Issue:3

    Topics: Adolescent; Anesthesia, General; Asthma; Bronchi; Bronchial Spasm; Bronchiectasis; Bronchitis; Bronc

1972
Intestinal ammonia in uraemia: the effect of a urease inhibitor, acetohydroxamic acid.
    Clinical science, 1972, Volume: 42, Issue:1

    Topics: Ammonia; Animals; Blood Proteins; Cecum; Colitis; Colon; Edema; Erythrocytes; Hydroxamic Acids; Infl

1972
[The presence of inflammatory cells in the rectal mucous secretion in patients with Crohn's disease in the terminal ileum].
    Nordisk medicin, 1971, Nov-11, Volume: 86, Issue:45

    Topics: Crohn Disease; Cytodiagnosis; Humans; Ileum; Inflammation; Intestinal Secretions; Mucus

1971
The presence of inflammatory leucocytes in the rectal mucus of patients with regional ileitis.
    Scandinavian journal of gastroenterology, 1971, Volume: 6, Issue:8

    Topics: Crohn Disease; Humans; Inflammation; Leukocytes; Mucus; Neutrophils; Rectum

1971
Eosinophilic granulocytes in the rectal mucus of patients with ulcerative colitis and Crohn's disease of the ileum and colon.
    Scandinavian journal of gastroenterology, 1971, Volume: 6, Issue:8

    Topics: Colitis, Ulcerative; Crohn Disease; Eosinophils; Humans; Inflammation; Mucus; Rectum

1971
[Experimental joining the skin with the mucous membrane of a bile duct and gallbladder].
    Arkhiv anatomii, gistologii i embriologii, 1967, Volume: 53, Issue:12

    Topics: Animals; Common Bile Duct; Dermatologic Surgical Procedures; Dogs; Duodenum; Epithelium; Gallbladder

1967
The cytology of "glue ear".
    The Journal of laryngology and otology, 1969, Volume: 83, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Ear, Middle; Epithelium; Eustachian Tube; Exudates and Transuda

1969
Virus studies in secretory otitis media.
    The Journal of laryngology and otology, 1969, Volume: 83, Issue:2

    Topics: Child; Complement Fixation Tests; Enterovirus; Exudates and Transudates; Humans; Inflammation; Mucus

1969