guaifenesin has been researched along with Infections, Respiratory Syncytial Virus in 29 studies
Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| " RESULTS A total of 62 participants received placebo or one of three ALS-008176 dosing regimens: 1 loading dose of 750 mg followed by 9 maintenance doses of 500 mg (group 1), 1 loading dose of 750 mg followed by 9 maintenance doses of 150 mg (group 2), or 10 doses of 375 mg (group 3)." | 2.80 | Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study. ( Beigelman, L; Blatt, LM; Chanda, S; DeVincenzo, JP; Fathi, H; Fry, J; Lambkin-Williams, R; McClure, MW; Smith, P; Symons, JA; Westland, C; Zhang, Q, 2015) |
| "Mucous cell metaplasia is a hallmark of asthma, and may be mediated by signal transducers and activators of transcription (STAT)-6 signaling." | 1.39 | IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia. ( Adler, KB; Boswell, MG; Boyd, KL; Brody, SL; Goleniewska, K; Kolls, JK; Newcomb, DC; Peebles, RS; Polosukhin, VV; Sherrill, TP, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 14 (48.28) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Du, X | 2 |
| Yang, Y | 2 |
| Yang, M | 2 |
| Yuan, L | 2 |
| Wang, L | 2 |
| Wu, M | 2 |
| Zhou, K | 1 |
| Li, W | 1 |
| Xiang, Y | 2 |
| Qu, X | 2 |
| Liu, H | 2 |
| Qin, X | 2 |
| Liu, C | 2 |
| McAllister, CS | 1 |
| Ansaldi, D | 1 |
| Growcott, EJ | 1 |
| Zhong, Y | 1 |
| Quackenbush, D | 1 |
| Wolff, KC | 1 |
| Chen, Z | 1 |
| Tanaseichuk, O | 1 |
| Lelais, G | 1 |
| Barnes, SW | 1 |
| Federe, GC | 1 |
| Luna, F | 1 |
| Walker, JR | 1 |
| Zhou, Y | 1 |
| Kuhen, KL | 1 |
| Xiao, G | 1 |
| Qin, L | 1 |
| He, R | 1 |
| Wu, S | 1 |
| Feng, J | 1 |
| Lee, Y | 1 |
| Lee, YT | 1 |
| Ko, EJ | 1 |
| Kim, KH | 1 |
| Hwang, HS | 1 |
| Park, S | 1 |
| Kwon, YM | 1 |
| Kang, SM | 1 |
| Stier, MT | 2 |
| Peebles, RS | 5 |
| Bohmwald, K | 1 |
| Gálvez, NMS | 1 |
| Canedo-Marroquín, G | 1 |
| Pizarro-Ortega, MS | 1 |
| Andrade-Parra, C | 1 |
| Gómez-Santander, F | 1 |
| Kalergis, AM | 1 |
| Boyoglu-Barnum, S | 1 |
| Gaston, KA | 1 |
| Todd, SO | 1 |
| Boyoglu, C | 1 |
| Chirkova, T | 1 |
| Barnum, TR | 1 |
| Jorquera, P | 1 |
| Haynes, LM | 1 |
| Tripp, RA | 1 |
| Moore, ML | 3 |
| Anderson, LJ | 1 |
| de Almeida Nagata, DE | 1 |
| Demoor, T | 1 |
| Ptaschinski, C | 1 |
| Ting, HA | 1 |
| Jang, S | 1 |
| Reed, M | 1 |
| Mukherjee, S | 3 |
| Lukacs, NW | 10 |
| DeVincenzo, JP | 1 |
| McClure, MW | 1 |
| Symons, JA | 1 |
| Fathi, H | 1 |
| Westland, C | 1 |
| Chanda, S | 1 |
| Lambkin-Williams, R | 1 |
| Smith, P | 1 |
| Zhang, Q | 1 |
| Beigelman, L | 1 |
| Blatt, LM | 1 |
| Fry, J | 1 |
| Bloodworth, MH | 1 |
| Toki, S | 1 |
| Newcomb, DC | 3 |
| Goleniewska, K | 4 |
| Boyd, KL | 2 |
| Quitalig, M | 1 |
| Hotard, AL | 1 |
| Hartert, TV | 1 |
| Zhou, B | 1 |
| McKenzie, AN | 1 |
| Chi, MH | 1 |
| Luongo, C | 1 |
| Polosukhin, VV | 2 |
| Huckabee, MM | 1 |
| Buchholz, UJ | 1 |
| Crowe, JE | 1 |
| Williams, JV | 1 |
| Collins, PL | 1 |
| Smit, JJ | 2 |
| Morris, SB | 2 |
| Nunez, G | 1 |
| Lindell, DM | 2 |
| van de Pol, AC | 1 |
| Wolfs, TF | 1 |
| van Loon, AM | 1 |
| Tacke, CE | 1 |
| Viveen, MC | 1 |
| Jansen, NJ | 1 |
| Kimpen, JL | 1 |
| Rossen, JW | 1 |
| Coenjaerts, FE | 1 |
| Kallal, LE | 1 |
| Hartigan, AJ | 1 |
| Hogaboam, CM | 1 |
| Schaller, MA | 2 |
| Berlin, AA | 3 |
| Shanley, TP | 1 |
| Hershenson, MB | 1 |
| Villenave, R | 1 |
| Thavagnanam, S | 1 |
| Sarlang, S | 1 |
| Parker, J | 1 |
| Douglas, I | 1 |
| Skibinski, G | 1 |
| Heaney, LG | 1 |
| McKaigue, JP | 1 |
| Coyle, PV | 1 |
| Shields, MD | 1 |
| Power, UF | 1 |
| Han, J | 1 |
| Dakhama, A | 1 |
| Jia, Y | 1 |
| Wang, M | 1 |
| Zeng, W | 1 |
| Takeda, K | 1 |
| Shiraishi, Y | 1 |
| Okamoto, M | 1 |
| Ziegler, SF | 1 |
| Gelfand, EW | 1 |
| Boswell, MG | 1 |
| Sherrill, TP | 1 |
| Brody, SL | 1 |
| Kolls, JK | 2 |
| Adler, KB | 1 |
| Miller, M | 2 |
| Cho, JY | 2 |
| Baek, KJ | 2 |
| Castaneda, D | 2 |
| Nayar, J | 2 |
| Rodriguez, M | 1 |
| Roman, M | 2 |
| Raz, E | 2 |
| Broide, DH | 2 |
| Heikkinen, T | 1 |
| Marttila, J | 1 |
| Salmi, AA | 1 |
| Ruuskanen, O | 1 |
| Miller, AL | 3 |
| Strieter, RM | 1 |
| Gruber, AD | 2 |
| Ho, SB | 2 |
| Wang, SZ | 2 |
| Bao, YX | 1 |
| Rosenberger, CL | 1 |
| Tesfaigzi, Y | 1 |
| Stark, JM | 1 |
| Harrod, KS | 2 |
| John, AE | 1 |
| Gerard, CJ | 1 |
| Schaller, M | 3 |
| Humbles, AA | 2 |
| Phaybouth, V | 1 |
| Hutt, JA | 1 |
| McDonald, JD | 1 |
| Barrett, EG | 1 |
| Hashimoto, K | 1 |
| Durbin, JE | 1 |
| Zhou, W | 1 |
| Collins, RD | 1 |
| Dubin, PJ | 1 |
| Sheller, JR | 1 |
| O'Neal, JF | 1 |
| Olson, SJ | 1 |
| Mitchell, D | 1 |
| Graham, BS | 1 |
| Rudd, BD | 1 |
| Flavell, RA | 1 |
| Alexopoulou, L | 1 |
| Gruber, A | 1 |
| Gerard, C | 1 |
| Smit, J | 1 |
| Lindell, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Phase 2a, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Pharmacokinetics and Antiviral Activity of Multiple Doses of Orally Administered ALS-008176 Against Respiratory Syncytial Virus Infection in the Virus Challenge Model[NCT02094365] | Phase 2 | 62 participants (Actual) | Interventional | 2014-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for guaifenesin and Infections, Respiratory Syncytial Virus
| Article | Year |
|---|---|
Host and Viral Determinants of Respiratory Syncytial Virus-induced Airway Mucus.
Topics: Humans; Infant; Mucins; Mucus; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, | 2018 |
Contribution of Cytokines to Tissue Damage During Human Respiratory Syncytial Virus Infection.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Line; Central Nervous System; Child; Child, Preschool; C | 2019 |
Respiratory syncytial virus-induced pulmonary disease and exacerbation of allergic asthma.
Topics: Animals; Asthma; Chemokines; Dendritic Cells; Disease Models, Animal; Humans; Immunity, Innate; Mice | 2007 |
1 trial available for guaifenesin and Infections, Respiratory Syncytial Virus
| Article | Year |
|---|---|
Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study.
Topics: Administration, Oral; Adolescent; Adult; Antiviral Agents; Area Under Curve; Deoxycytidine; Double-B | 2015 |
25 other studies available for guaifenesin and Infections, Respiratory Syncytial Virus
| Article | Year |
|---|---|
ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells.
Topics: Animals; Disease Models, Animal; Epithelial Cells; Humans; Integrin beta4; Mice; Mucin 5AC; Mucus; R | 2022 |
Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling.
Topics: Animals; Cell Line; Cytokines; Dexamethasone; Gene Regulatory Networks; Host-Pathogen Interactions; | 2020 |
Respiratory syncytial virus infection-induced mucus secretion by down-regulation of miR-34b/c-5p expression in airway epithelial cells.
Topics: Anthracenes; Child; Down-Regulation; Epithelial Cells; Gene Expression Profiling; Gene Ontology; Gen | 2020 |
Soluble F proteins exacerbate pulmonary histopathology after vaccination upon respiratory syncytial virus challenge but not when presented on virus-like particles.
Topics: Animals; Antibodies, Neutralizing; Antibodies, Viral; Humans; Immunogenicity, Vaccine; Immunoglobuli | 2017 |
A respiratory syncytial virus (RSV) anti-G protein F(ab')2 monoclonal antibody suppresses mucous production and breathing effort in RSV rA2-line19F-infected BALB/c mice.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Viral; Chemoprevention; Disease Models, Animal; Female; | 2013 |
IL-27R-mediated regulation of IL-17 controls the development of respiratory syncytial virus-associated pathogenesis.
Topics: Animals; Chloride Channels; Interleukin-17; Interleukins; Mice; Mice, Knockout; Minor Histocompatibi | 2014 |
Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin.
Topics: Animals; Cytokines; Female; Interleukin-13; Interleukin-33; Lung; Lymphocytes; Mice, Inbred BALB C; | 2016 |
A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction.
Topics: Animals; Base Sequence; Cell Line, Tumor; Genome, Viral; Humans; Interleukin-13; Mice; Mice, Inbred | 2009 |
Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulation.
Topics: Animals; Cytokines; Dendritic Cells; Flow Cytometry; Goblet Cells; Hyperplasia; Interleukin-17; Inte | 2010 |
Molecular quantification of respiratory syncytial virus in respiratory samples: reliable detection during the initial phase of infection.
Topics: Humans; Infant; Mucus; Nasopharynx; Respiratory Syncytial Virus Infections; Respiratory Syncytial Vi | 2010 |
Inefficient lymph node sensitization during respiratory viral infection promotes IL-17-mediated lung pathology.
Topics: Animals; Cell Separation; Chemotaxis, Leukocyte; Choristoma; Flow Cytometry; Interleukin-17; Lung Di | 2010 |
IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; CD8-Positive T-Lymphocytes; Disease Models, Anim | 2011 |
In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo.
Topics: Apoptosis; Bronchi; Cell Differentiation; Chemokines; Child; Cilia; Cytopathogenic Effect, Viral; Ep | 2012 |
Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand.
Topics: Animals; Animals, Newborn; Antibodies, Blocking; Bronchial Hyperreactivity; Cell Movement; Cells, Cu | 2012 |
IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia.
Topics: Adoptive Transfer; Animals; Bronchoalveolar Lavage Fluid; Female; Interleukin-13; Interleukin-17; Lu | 2013 |
Plasmid DNA encoding the respiratory syncytial virus G protein protects against RSV-induced airway hyperresponsiveness.
Topics: Animals; Antibodies, Viral; Base Sequence; Bronchoalveolar Lavage Fluid; Female; Humans; Immunoglobu | 2002 |
Nasal swab versus nasopharyngeal aspirate for isolation of respiratory viruses.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Mucus; Nasophary | 2002 |
CXCR2 regulates respiratory syncytial virus-induced airway hyperreactivity and mucus overproduction.
Topics: Animals; Bronchial Hyperreactivity; Bronchiolitis, Viral; Disease Models, Animal; Female; Goblet Cel | 2003 |
IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection.
Topics: Adjuvants, Immunologic; Alcian Blue; Animals; Antibodies, Blocking; Bronchiolitis, Viral; Bronchoalv | 2004 |
Respiratory syncytial virus-induced exaggeration of allergic airway disease is dependent upon CCR1-associated immune responses.
Topics: Allergens; Animals; Asthma; Cockroaches; Female; Humans; Immunity, Cellular; Interleukin-13; Lung; M | 2005 |
Cigarette smoke suppresses Th1 cytokine production and increases RSV expression in a neonatal model.
Topics: Animals; Animals, Newborn; Cytokines; Disease Models, Animal; Female; Inflammation Mediators; Interl | 2006 |
Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels.
Topics: Animals; Blotting, Western; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chloride Channe | 2005 |
Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Line; Chloride Channels; Cytokines; Gene Deletion; Human | 2006 |
Deletion of CCR1 attenuates pathophysiologic responses during respiratory syncytial virus infection.
Topics: Animals; Bone Marrow; Chemokines; Cytokines; Gene Deletion; Mice; Mice, Inbred BALB C; Mice, Knockou | 2006 |
Immunostimulatory DNA sequences inhibit respiratory syncytial viral load, airway inflammation, and mucus secretion.
Topics: Adjuvants, Immunologic; Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Bronchoconstrictor A | 2001 |