Page last updated: 2024-10-28

guaifenesin and Gastroesophageal Reflux

guaifenesin has been researched along with Gastroesophageal Reflux in 20 studies

Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.

Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.

Research Excerpts

ExcerptRelevanceReference
" The underlying reflex mechanisms responsible for such swallows during apnea are unclear."3.67Pulmonary protective mechanisms in human infants. ( Menon, A; Thach, BT, 1985)
"Chronic cough is a common problem of various etiologies."2.79The assessment and management of chronic cough in children according to the British Thoracic Society guidelines: descriptive, prospective, clinical trial. ( Asilsoy, S; Durmaz, C; Usta Guc, B, 2014)
"Gastroesophageal reflux is common among patients with postnasal drainage."2.75Proton pump inhibitor therapy improves symptoms in postnasal drainage. ( Allocco, CT; Clement, LE; Duncavage, JA; Goutte, M; Hagaman, DD; Lanza, DC; McCafferty, BA; Slaughter, JC; Sparkman, C; Tanner, SB; Vaezi, MF; Wasden, CM; Wirth, D, 2010)
"However, there is a risk of gastroesophageal reflux associated with this technique."2.52Standard (head-down tilt) versus modified (without head-down tilt) postural drainage in infants and young children with cystic fibrosis. ( Chaves, GS; Dias, FA; Ferreira, GM; Freitas, DA; Guerra, RO; Mendonça, KM; Ribeiro, CT, 2015)
"Gastroesophageal reflux (GER), through the occurrence of gastroesophagopharyngeal reflux (GEPR), is an established cause of several otorhinolaryngological (ORL) manifestations."1.33The role of (duodeno)gastroesophagopharyngeal reflux in unexplained excessive throat phlegm. ( Feenstra, L; Poelmans, J; Tack, J, 2005)
"Cough was due to one condition in 73%, two in 23%, and three in 3%."1.28Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. ( Curley, FJ; French, CL; Irwin, RS, 1990)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19906 (30.00)18.7374
1990's1 (5.00)18.2507
2000's8 (40.00)29.6817
2010's4 (20.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
de Souza, TA1
Carneiro, AP1
Narciso, AS1
Barros, CP1
Alves, DA1
Marson, LB1
Tunala, T1
de Alcântara, TM1
de Paiva Maia, YC1
Briza, P1
Ferreira, F1
Goulart, LR1
Usta Guc, B1
Asilsoy, S1
Durmaz, C1
Freitas, DA1
Dias, FA1
Chaves, GS1
Ferreira, GM1
Ribeiro, CT1
Guerra, RO1
Mendonça, KM1
Robb-Nicholson, C1
Vaezi, MF1
Hagaman, DD1
Slaughter, JC1
Tanner, SB1
Duncavage, JA1
Allocco, CT1
Sparkman, C1
Clement, LE1
Wasden, CM1
Wirth, D1
Goutte, M1
McCafferty, BA1
Lanza, DC1
Morice, AH1
Poelmans, J1
Feenstra, L1
Tack, J1
O'Hara, J1
Jones, NS1
Beaver, ME1
Stasney, CR1
Rodriguez, M1
Lang, IM1
Haworth, ST1
Medda, BK1
Roerig, DL1
Forster, HV1
Shaker, R1
Domschke, W1
Schumpelick, V1
Muers, MF1
Olnes, SQ1
Schwartz, RH1
Bahadori, RS1
Irwin, RS1
Curley, FJ1
French, CL1
Orlando, RC1
Siegel, SC1
Rachelefsky, GS1
Thach, BT1
Menon, A1
Kalm, O1
Rundcrantz, H1
Thiséus, S1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phenotypic Characterization of Pediatric Patients With Esophageal Eosinophilia and Biomarkers Investigation for the Diagnosis of Eosinophilic Esophagitis[NCT03069573]110 participants (Actual)Observational [Patient Registry]2015-01-01Completed
Assessment of Radio(Chemo)Therapy-related Dysphagia in Head and Neck Cancer Patients Based on Cough-related Acoustic Features[NCT05865756]40 participants (Anticipated)Interventional2021-04-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for guaifenesin and Gastroesophageal Reflux

ArticleYear
Standard (head-down tilt) versus modified (without head-down tilt) postural drainage in infants and young children with cystic fibrosis.
    The Cochrane database of systematic reviews, 2015, Mar-10, Issue:3

    Topics: Anti-Bacterial Agents; Child, Preschool; Cystic Fibrosis; Disease Progression; Drainage, Postural; G

2015
Post-nasal drip syndrome--a symptom to be sniffed at?
    Pulmonary pharmacology & therapeutics, 2004, Volume: 17, Issue:6

    Topics: Asthma; Cough; Diagnosis, Differential; Gastroesophageal Reflux; Humans; Mucus; Nasal Cavity; Rhinit

2004
The aetiology of chronic cough: a review of current theories for the otorhinolaryngologist.
    The Journal of laryngology and otology, 2005, Volume: 119, Issue:7

    Topics: Angiotensin-Converting Enzyme Inhibitors; Asthma; Bronchitis, Chronic; Chronic Disease; Cough; Eosin

2005
[Stress ulcer: mechanisms of aggression and protection].
    Deutsche medizinische Wochenschrift (1946), 1983, Mar-31, Volume: 108, Issue:13

    Topics: Animals; Epithelium; Gastric Acid; Gastric Mucosa; Gastroesophageal Reflux; Humans; Ischemia; Microc

1983
Continuing medical education. Asthma in infants and children: Part 1.
    The Journal of allergy and clinical immunology, 1985, Volume: 76, Issue:1

    Topics: Airway Resistance; Allergens; Aspirin; Asthma; Asthma, Exercise-Induced; Bronchi; Child; Child, Pres

1985

Trials

2 trials available for guaifenesin and Gastroesophageal Reflux

ArticleYear
The assessment and management of chronic cough in children according to the British Thoracic Society guidelines: descriptive, prospective, clinical trial.
    The clinical respiratory journal, 2014, Volume: 8, Issue:3

    Topics: Adolescent; Asthma; Bronchitis; Child; Child, Preschool; Chronic Disease; Cough; Female; Gastroesoph

2014
Proton pump inhibitor therapy improves symptoms in postnasal drainage.
    Gastroenterology, 2010, Volume: 139, Issue:6

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Chronic Disease; Education, Medical, Continuing; Enz

2010

Other Studies

13 other studies available for guaifenesin and Gastroesophageal Reflux

ArticleYear
Eosinophilic esophagitis auxiliary diagnosis based on a peptide ligand to eosinophil cationic protein in esophageal mucus of pediatric patients.
    Scientific reports, 2022, 07-18, Volume: 12, Issue:1

    Topics: Child; Chromatography, Liquid; Enteritis; Eosinophil Cationic Protein; Eosinophilia; Eosinophilic Es

2022
Health tips. Stopping postnasal drip.
    Mayo Clinic health letter (English ed.), 2013, Volume: 31, Issue:5

    Topics: Allergens; Caffeine; Chronic Disease; Cough; Drinking; Gastroesophageal Reflux; Humans; Mucus; Nasal

2013
By the way, doctor. I developed a hoarse voice and annoying phlegm in my throat and was surprised to learn that the cause was acid reflux. I've never had heartburn, so I don't know how this could have happened. Can you explain?
    Harvard women's health watch, 2009, Volume: 17, Issue:4

    Topics: Esophagitis; Food Preferences; Gastroesophageal Reflux; Health Knowledge, Attitudes, Practice; Hoars

2009
The role of (duodeno)gastroesophagopharyngeal reflux in unexplained excessive throat phlegm.
    Digestive diseases and sciences, 2005, Volume: 50, Issue:5

    Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Chronic Disease; Color; Duodenogastric Reflux; Endoscopy

2005
Mucus retention cyst and reflux disease.
    Ear, nose, & throat journal, 2005, Volume: 84, Issue:11

    Topics: Female; Gastroesophageal Reflux; Hoarseness; Humans; Middle Aged; Mucocele; Mucus; Proton Pump Inhib

2005
Chronic cough. It can be helped.
    Mayo Clinic health letter (English ed.), 2006, Volume: 24, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Asthma; Chronic Disease; Cough; Gastroesophageal Reflux; H

2006
Airway responses to esophageal acidification.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:1

    Topics: Airway Resistance; Animals; Bronchi; Cats; Disease Models, Animal; Esophagus; Female; Gastroesophage

2008
Diurnal variation in asthma.
    Archives of disease in childhood, 1984, Volume: 59, Issue:9

    Topics: Airway Resistance; Asthma; Bronchodilator Agents; Circadian Rhythm; Epinephrine; Gastroesophageal Re

1984
Consultation with the specialist: Diagnosis and management of the newborn and young infant who have nasal obstruction.
    Pediatrics in review, 2000, Volume: 21, Issue:12

    Topics: Choanal Atresia; Female; Gastroesophageal Reflux; Hamartoma; Humans; Infant; Infant, Newborn; Male;

2000
Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy.
    The American review of respiratory disease, 1990, Volume: 141, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchial Provocation Tests; Child; Chronic Dise

1990
Esophageal epithelial resistance.
    Journal of clinical gastroenterology, 1986, Volume: 8 Suppl 1

    Topics: Bicarbonates; Epithelium; Esophagitis, Peptic; Esophagus; Gastroesophageal Reflux; Humans; Hydrogen-

1986
Pulmonary protective mechanisms in human infants.
    The American review of respiratory disease, 1985, Volume: 131, Issue:5

    Topics: Apnea; Deglutition; Electromyography; Gastroesophageal Reflux; Humans; Infant, Newborn; Mucus; Pneum

1985
[Back-nasal catarrh].
    Nordisk medicin, 1970, Oct-29, Volume: 83, Issue:44

    Topics: Esophagus; Gastroesophageal Reflux; Hernia, Diaphragmatic; Humans; Mucus; Nasal Mucosa; Nasopharynge

1970