guaifenesin and Fecal Incontinence

guaifenesin has been researched along with Fecal Incontinence in 5 studies

Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.

Fecal Incontinence: Failure of voluntary control of the anal sphincters, with involuntary passage of feces and flatus.

Research

Studies (5)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Anal Incontinence

The FISI is a validated instrument for assessing fecal incontinence symptom severity. The questionnaire contains 4 questions that assess the frequency of incontinence of solid stool, liquid stool, mucus and gas. FISI total scores range from 0-61 points and higher scores on the scale indicate greater severity of anal incontinence symptoms (worse symptoms). The following are ranges of the scores for each subscale, similarly higher scores on the scale indicate greater severity of subtype of anal incontinence (worse symptoms) Gas subscale- 0-12 points Mucus subscale: 0- 12 points Liquid stool subscale: 0-19 points Solid stool subscale: 0-18 points There are units for the scores on the scale. The Total FISI score is derived from the sum of all the scores on the subscales. (NCT02701413)
Timeframe: 13 weeks postpartum

Maximum Squeeze Anal Pressure

Anal manometry will be used to obtain the maximum squeeze pressures and this will be compared between the electrical stimulation and sham group. Anorectal manometry was performed using a microtipped transducer anorectal manometry system with Laborie software and a 4-channel Gaeltec catheter (Laborie Medical Technologies Co., Williston, VT, and Unisensor, Inc, Hampton, NH). Maximum squeeze pressures at 1, 2, 3, 4, and 5cm proximal to the anal verge were recorded in the semi recumbent position. Maximum squeeze pressure was defined as the highest pressure recorded above the baseline (zero) at any level of the anal canal during maximum squeeze effort by the patient (NCT02701413)
Timeframe: 13 weeks postpartum

Number of Participants With Levator Ani Muscle Defects on Either Side of the Pelvis

"Endovaginal ultrasound will be used to determine the relationship between levator ani muscle defects between the electrical stimulation and sham group.~We defined levator ani defect as the separation (avulsion) of any of the levator muscles from one of their primary attachment sites on ultrasound.~For levator ani defects, the presence or absence of levator ani avulsion (separation from the pubic bone) will be noted on each side. Number of patients with and without these avulsions defects will be compared between the two groups." (NCT02701413)
Timeframe: 13 weeks postpartum

Number of Patients With Anal Sphincter Muscle Defects

For anal sphincter muscle defects, the number of patients with anal sphincter muscles (out of 360 degrees) will be reported. The proportion of patients with anal sphincter defects in each group will be compared between the two groups. (NCT02701413)
Timeframe: 13 weeks postpartum

Other Studies

5 other studies available for guaifenesin and Fecal Incontinence