Page last updated: 2024-10-28

guaifenesin and Eosinophilia, Pulmonary

guaifenesin has been researched along with Eosinophilia, Pulmonary in 41 studies

Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.

Research Excerpts

ExcerptRelevanceReference
"Chronic eosinophilic pneumonia is a rare cause of chronic lung disease in children."1.36Chronic eosinophilic pneumonia with mucous plugs in a child. ( Aksoy, F; Cakir, E; Cakır, FB; Ertem, T, 2010)
" Inhalation of aerosolized p38alpha-ASO using an aerosol chamber dosing system produced measurable lung deposition of ASO and significant reduction of ovalbumin (OVA-)-induced increases in total cells, eosinophils, and interleukin 4 (IL-4), IL-5, and IL-13 levels in bronchoalveolar lavage fluid, and dose-dependent inhibition of airway hyperresponsiveness in allergen-challenged mice."1.33Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice. ( Chan, JH; Choo, HH; Crosby, JR; Duan, W; Karras, JG; Leung, BP; McKay, K; Wong, WS, 2005)
"This strategy resulted in a pulmonary eosinophilia equivalent to that observed in OVA-treated wild-type animals."1.32A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse. ( Ansay, TL; Biechelle, TL; Borchers, MT; Colbert, DC; Cormier, SA; Crosby, JR; Hines, EM; Justice, JP; Lee, JJ; Lee, NA; McGarry, MP; O'Neill, KR; Ochkur, SI; Shen, HH; Wang, H, 2003)
"This is the first evidence that autoimmune diabetes-prone NOD mice can also give rise to enhanced Th2-mediated responses and might thus provide a useful model for the study of common genetic and cellular components, including NKT cells that contribute to both asthma and type 1 diabetes."1.32Exacerbated Th2-mediated airway inflammation and hyperresponsiveness in autoimmune diabetes-prone NOD mice: a critical role for CD1d-dependent NKT cells. ( Araujo, LM; Bach, JF; Diem, S; Dy, M; Herbelin, A; Lefort, J; Leite-de-Moraes, MC; Nahori, MA; Vargaftig, BB; Zhu, R, 2004)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19903 (7.32)18.7374
1990's2 (4.88)18.2507
2000's23 (56.10)29.6817
2010's8 (19.51)24.3611
2020's5 (12.20)2.80

Authors

AuthorsStudies
Hearn, AP1
Mak, MS1
Budaj, I1
Qurashi, N1
Snell, O1
Dhariwal, J1
Nanzer, AM1
Jackson, DJ1
McIntosh, MJ2
Kooner, HK2
Eddy, RL2
Jeimy, S1
Licskai, C2
Mackenzie, CA2
Svenningsen, S1
Nair, P1
Yamashita, C2
Parraga, G2
Wilson, A1
Serajeddini, H1
Bhalla, A1
Sakai, N1
Koya, T1
Murai, Y1
Tsubokawa, F1
Tanaka, K1
Naramoto, S1
Aoki, A1
Shima, K1
Kimura, Y1
Watanabe, S1
Hasegawa, T1
Kikuchi, T1
Brown, R1
Paulsen, M1
Schmidt, S1
Schatterny, J1
Frank, A1
Hirtz, S1
Delaney, R1
Doherty, D1
Hagner, M1
Taggart, C1
Weldon, S1
Mall, MA1
Mochimaru, T1
Fukunaga, K1
Ueda, S1
Kuroda, A1
Watanabe, R1
Chubachi, S1
Betsuyaku, T1
Collison, A1
Li, J1
Pereira de Siqueira, A1
Zhang, J1
Toop, HD1
Morris, JC1
Foster, PS2
Mattes, J1
Nau, F1
Miller, J1
Saravia, J1
Ahlert, T1
Yu, B1
Happel, KI1
Cormier, SA2
Nichols, CD1
Sel, S1
Rost, BR1
Yildirim, AO1
Sel, B1
Kalwa, H1
Fehrenbach, H1
Renz, H1
Gudermann, T1
Dietrich, A1
Lee, NH1
Lee, MY2
Lee, JA1
Jung, DY1
Seo, CS1
Kim, JH2
Shin, HK1
Cakir, E1
Aksoy, F1
Cakır, FB1
Ertem, T1
Cho, JY2
Pham, A1
Rosenthal, P1
Miller, M2
Doherty, T1
Broide, DH2
Halim, TY1
Krauss, RH1
Sun, AC1
Takei, F1
Han, J1
Dakhama, A1
Jia, Y1
Wang, M1
Zeng, W1
Takeda, K1
Shiraishi, Y1
Okamoto, M1
Ziegler, SF1
Gelfand, EW2
Cohn, L2
Whittaker, L1
Niu, N1
Homer, RJ2
Shen, HH1
Ochkur, SI1
McGarry, MP1
Crosby, JR2
Hines, EM1
Borchers, MT1
Wang, H1
Biechelle, TL1
O'Neill, KR1
Ansay, TL1
Colbert, DC1
Justice, JP1
Lee, NA1
Lee, JJ1
ALBERICI, RA1
Araujo, LM1
Lefort, J2
Nahori, MA2
Diem, S1
Zhu, R1
Dy, M1
Leite-de-Moraes, MC1
Bach, JF1
Vargaftig, BB2
Herbelin, A1
Duan, W2
Chan, JH1
McKay, K1
Choo, HH1
Leung, BP2
Karras, JG1
Wong, WS2
Aguinaldo Datiles, AM1
Vlahos, CJ1
Xie, LX1
Mo, GX1
Chen, LA1
Liu, YN1
Oh, SR1
Ahn, K1
Park, BY1
Kwon, OK1
Joung, H1
Lee, J1
Kim, DY1
Lee, S1
Lee, HK1
Venkataraman, C1
Justen, K1
Zhao, J1
Galbreath, E1
Na, S1
Fulkerson, PC1
Fischetti, CA1
Rothenberg, ME2
Steenwinckel, V1
Louahed, J1
Orabona, C1
Huaux, F1
Warnier, G1
McKenzie, A1
Lison, D1
Levitt, R1
Renauld, JC1
Le, AV1
McElwain, S1
Golgotiu, K1
Han, X2
Fan, Y3
Wang, S3
Jiao, L1
Qiu, H1
Yang, X3
Henderson, WR2
Lewis, DB1
Albert, RK1
Zhang, Y1
Lamm, WJ1
Chiang, GK2
Jones, F2
Eriksen, P1
Tien, YT1
Jonas, M1
Chi, EY2
Zhu, L1
Wang, J1
Hong, L1
Lee, CG1
Jung, S1
Elias, JA1
Tomkinson, A1
Duez, C1
Cieslewicz, G1
Pratt, JC1
Joetham, A1
Shanafelt, MC1
Gundel, R1
Russo, M1
Gomes, E1
de Castro Keller, A1
Rodriguez, D1
Ribeiro, OG1
Adriouch, S1
Gallois, V1
de Faria, AM1
Pope, SM1
Brandt, EB1
Mishra, A1
Hogan, SP1
Zimmermann, N1
Matthaei, KI1
Walter, DM1
McIntire, JJ1
Berry, G1
McKenzie, AN1
Donaldson, DD1
DeKruyff, RH1
Umetsu, DT1
Oh, SW1
Pae, CI1
Lee, DK1
Kim, HO1
Moon, SH1
Cao, B1
Ogbu, C1
Jeong, KW1
Kozu, G1
Nakanishi, H1
Kahn, M1
Tigani, B1
Schaeublin, E1
Sugar, R1
Jackson, AD1
Fozard, JR1
Beckmann, N1
Yang, J1
Bilenki, L1
Chen, L1
Hurst, SD1
Muchamuel, T1
Gorman, DM1
Gilbert, JM1
Clifford, T1
Kwan, S1
Menon, S1
Seymour, B1
Jackson, C1
Kung, TT1
Brieland, JK1
Zurawski, SM1
Chapman, RW1
Zurawski, G1
Coffman, RL1
Mathew, A1
Medoff, BD1
Carafone, AD1
Luster, AD1
Geddes, DM1
Madewell, JE1
Montgomery, JL1
Cavanagh, RC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Mechanistic Pilot Open-label Study to Evaluate the Effect of Benralizumab on Airway Function and Inflammation in Patients With Severe, Poorly-controlled Eosinophilic Asthma Using Inhaled Hyperpolarized 129-Xenon MRI[NCT03733535]29 participants (Actual)Interventional2022-03-01Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for guaifenesin and Eosinophilia, Pulmonary

ArticleYear
Asthma Control, Airway Mucus, and
    Chest, 2022, Volume: 162, Issue:3

    Topics: Airway Management; Airway Obstruction; Anti-Asthmatic Agents; Antibodies, Monoclonal, Humanized; Ast

2022

Other Studies

40 other studies available for guaifenesin and Eosinophilia, Pulmonary

ArticleYear
The prevalence of mucus plugging in severe eosinophilic asthma and its relationship to clinical efficacy of anti-IL-5R treatment.
    The journal of allergy and clinical immunology. In practice, 2022, Volume: 10, Issue:4

    Topics: Asthma; Eosinophils; Humans; Mucus; Prevalence; Pulmonary Eosinophilia; Treatment Outcome

2022
CT Mucus Score and
    Chest, 2023, Volume: 164, Issue:1

    Topics: Airway Obstruction; Anti-Asthmatic Agents; Asthma; Humans; Magnetic Resonance Imaging; Mucus; Nitric

2023
Effect of Benralizumab on Mucus Plugs in Severe Eosinophilic Asthma.
    International archives of allergy and immunology, 2023, Volume: 184, Issue:8

    Topics: Anti-Asthmatic Agents; Asthma; Disease Progression; Eosinophils; Humans; Mucus; Pulmonary Eosinophil

2023
Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease.
    American journal of respiratory cell and molecular biology, 2020, Volume: 62, Issue:3

    Topics: Aging; Animals; Antibodies; Apoptosis; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Cytokine

2020
Allergic bronchopulmonary aspergillosis in succession to chronic eosinophilic pneumonia.
    Allergology international : official journal of the Japanese Society of Allergology, 2019, Volume: 68, Issue:3

    Topics: Adult; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Bronchiectasis; Chronic Dise

2019
Tumor necrosis factor-related apoptosis-inducing ligand regulates hallmark features of airways remodeling in allergic airways disease.
    American journal of respiratory cell and molecular biology, 2014, Volume: 51, Issue:1

    Topics: Airway Remodeling; Animals; Apoptosis; Blotting, Western; Bronchial Hyperreactivity; Cytokines; Immu

2014
Serotonin 5-HT₂ receptor activation prevents allergic asthma in a mouse model.
    American journal of physiology. Lung cellular and molecular physiology, 2015, Jan-15, Volume: 308, Issue:2

    Topics: 5-Hydroxytryptophan; Amphetamines; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactiv

2015
Loss of classical transient receptor potential 6 channel reduces allergic airway response.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2008, Volume: 38, Issue:9

    Topics: Animals; Bronchial Hyperreactivity; Cells, Cultured; Epithelial Cells; Guinea Pigs; Hypersensitivity

2008
Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model.
    International journal of molecular medicine, 2010, Volume: 26, Issue:2

    Topics: Analysis of Variance; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokine

2010
Chronic eosinophilic pneumonia with mucous plugs in a child.
    Pediatric pulmonology, 2010, Volume: 45, Issue:10

    Topics: Bronchoscopy; Child; Eosinophilia; Female; Humans; Mucus; Pulmonary Eosinophilia

2010
Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling.
    International immunopharmacology, 2011, Volume: 11, Issue:8

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchi; Collagen; Eosinophils; Extracellular Matrix

2011
Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation.
    Immunity, 2012, Mar-23, Volume: 36, Issue:3

    Topics: Adoptive Transfer; Allergens; Animals; Asthma; Cytokines; Disease Models, Animal; Gene Expression Pr

2012
Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand.
    The Journal of allergy and clinical immunology, 2012, Volume: 130, Issue:5

    Topics: Animals; Animals, Newborn; Antibodies, Blocking; Bronchial Hyperreactivity; Cell Movement; Cells, Cu

2012
Cytokine regulation of mucus production in a model of allergic asthma.
    Novartis Foundation symposium, 2002, Volume: 248

    Topics: Administration, Inhalation; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Exocytos

2002
A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Mar-15, Volume: 170, Issue:6

    Topics: Adoptive Transfer; Aerosols; Allergens; Animals; Bronchial Hyperreactivity; CD4-Positive T-Lymphocyt

2003
[Mucous plugs of bronchi in asthma & Hoffmann & Teichmüller eosinophilic catarrhs].
    Revista brasileira de medicina, 1957, Volume: 14, Issue:4

    Topics: Asthma; Bronchi; Common Cold; Humans; Mucus; Pulmonary Eosinophilia; Respiratory Tract Diseases

1957
Exacerbated Th2-mediated airway inflammation and hyperresponsiveness in autoimmune diabetes-prone NOD mice: a critical role for CD1d-dependent NKT cells.
    European journal of immunology, 2004, Volume: 34, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antigens, CD1; Antigens, CD1d; Asthma; Bronchial Hyperreactivity; B

2004
Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice.
    American journal of respiratory and critical care medicine, 2005, Mar-15, Volume: 171, Issue:6

    Topics: Administration, Inhalation; Aerosols; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar La

2005
An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model.
    International immunopharmacology, 2005, Volume: 5, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Movement; Chromones; C

2005
Chronic eosinophilic pneumonia with mucous plugs: case report.
    Chinese medical journal, 2006, Feb-05, Volume: 119, Issue:3

    Topics: Adult; Chronic Disease; Female; Humans; Mucus; Pulmonary Eosinophilia

2006
Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma.
    International immunopharmacology, 2006, Volume: 6, Issue:6

    Topics: Acetates; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disea

2006
Death receptor-6 regulates the development of pulmonary eosinophilia and airway inflammation in a mouse model of asthma.
    Immunology letters, 2006, Jul-15, Volume: 106, Issue:1

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Interferon-gamma; Mic

2006
Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling.
    The American journal of pathology, 2006, Volume: 169, Issue:6

    Topics: Animals; Asthma; Chemokine CCL11; Chemokines, CC; Collagen; Eosinophils; Inflammation; Interleukin-1

2006
IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Mar-01, Volume: 178, Issue:5

    Topics: Animals; Asthma; Chemokine CCL11; Chemokines, CC; Epithelial Cells; Hematopoietic Stem Cell Transpla

2007
Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Jun-01, Volume: 178, Issue:11

    Topics: Activins; Allergens; Animals; Azo Compounds; Bronchial Hyperreactivity; Cell Movement; Collagen; Eos

2007
NK cells contribute to intracellular bacterial infection-mediated inhibition of allergic responses.
    Journal of immunology (Baltimore, Md. : 1950), 2008, Apr-01, Volume: 180, Issue:7

    Topics: Allergens; Animals; Cell Separation; Chlamydia muridarum; Cytokines; Female; Hypersensitivity; Kille

2008
The importance of leukotrienes in airway inflammation in a mouse model of asthma.
    The Journal of experimental medicine, 1996, Oct-01, Volume: 184, Issue:4

    Topics: 5-Lipoxygenase-Activating Proteins; Allergens; Animals; Asthma; Bronchial Provocation Tests; Broncho

1996
Systemic mycobacterial infection inhibits antigen-specific immunoglobulin E production, bronchial mucus production and eosinophilic inflammation induced by allergen.
    Immunology, 1999, Volume: 98, Issue:3

    Topics: Allergens; Animals; Bronchi; Female; Goblet Cells; Immunoglobulin E; Immunoglobulin G; Interferon-ga

1999
IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Aug-15, Volume: 165, Issue:4

    Topics: Administration, Inhalation; Aerosols; Allergens; Animals; Bronchoalveolar Lavage Fluid; Cytokines; G

2000
A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness.
    Journal of immunology (Baltimore, Md. : 1950), 2001, May-01, Volume: 166, Issue:9

    Topics: Animals; Antibody Specificity; B-Lymphocyte Subsets; Bronchial Hyperreactivity; Bronchoalveolar Lava

2001
Suppression of asthma-like responses in different mouse strains by oral tolerance.
    American journal of respiratory cell and molecular biology, 2001, Volume: 24, Issue:5

    Topics: Administration, Inhalation; Administration, Oral; Animals; Antibodies; Antigens; Asthma; Bronchial P

2001
IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism.
    The Journal of allergy and clinical immunology, 2001, Volume: 108, Issue:4

    Topics: Animals; Chemokine CCL11; Chemokines, CC; Chemotaxis, Leukocyte; Cytokines; Female; Interleukin-13;

2001
Critical role for IL-13 in the development of allergen-induced airway hyperreactivity.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Oct-15, Volume: 167, Issue:8

    Topics: Adoptive Transfer; Allergens; Animals; Immunity, Innate; Interferon-gamma; Interleukin-13; Interleuk

2001
Tryptase inhibition blocks airway inflammation in a mouse asthma model.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Feb-15, Volume: 168, Issue:4

    Topics: Animals; Asthma; Bridged Bicyclo Compounds, Heterocyclic; Bronchial Diseases; Bronchial Hyperreactiv

2002
Pulmonary inflammation monitored noninvasively by MRI in freely breathing rats.
    Biochemical and biophysical research communications, 2002, Mar-22, Volume: 292, Issue:1

    Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Budesonide; Eosi

2002
Mycobacterial infection inhibits established allergic inflammatory responses via alteration of cytokine production and vascular cell adhesion molecule-1 expression.
    Immunology, 2002, Volume: 105, Issue:3

    Topics: Animals; Antigens; Asthma; Cytokines; Endothelium, Vascular; Female; Immune Tolerance; Immunoglobuli

2002
New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Jul-01, Volume: 169, Issue:1

    Topics: Adenoviridae; Administration, Intranasal; Amino Acid Motifs; Amino Acid Sequence; Animals; Aspergill

2002
Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Jul-15, Volume: 169, Issue:2

    Topics: Adoptive Transfer; Aerosols; Animals; Bronchoalveolar Lavage Fluid; Cell Migration Inhibition; Cell

2002
Pulmonary eosinophilia.
    Journal of the Royal College of Physicians of London, 1986, Volume: 20, Issue:2

    Topics: Aspergillosis, Allergic Bronchopulmonary; Asthma; Drug-Related Side Effects and Adverse Reactions; E

1986
RPC from the AFIP.
    Radiology, 1973, Volume: 108, Issue:1

    Topics: Adenoma; Adult; Airway Obstruction; Arteriovenous Fistula; Bronchi; Bronchial Diseases; Carcinoma, B

1973