guaifenesin has been researched along with Disease Models, Animal in 398 studies
Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " azedarach fruit extract (MAE) using high-performance liquid chromatography (HPLC) and explored the therapeutic effects of MAE on pulmonary inflammation and mucus hypersecretion using a murine model of ovalbumin (OVA) exposed asthma." | 8.84 | Melia azedarach L. reduces pulmonary inflammation and mucus hypersecretion on a murine model of ovalbumin exposed asthma. ( Kim, T; Kim, WI; Lee, IS; Lee, SJ; Pak, SW; Shin, IS; Yang, YG, 2024) |
| "We demonstrated that intranasal adenosine administration effectively decreased inflammation and mucus production in a mouse model of viral ARS." | 8.31 | Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis. ( Ganama, M; Hua, X; Tilley, S; Varga, SM; Waldstein, KA, 2023) |
| " In this study, we explored the suppressive effects of SAC on allergic airway inflammation induced in an ovalbumin (OVA)-induced asthma mouse model." | 7.91 | S-Allyl cysteine reduces eosinophilic airway inflammation and mucus overproduction on ovalbumin-induced allergic asthma model. ( Kim, JC; Kim, JS; Kim, SH; Ko, JW; Kwon, HJ; Lee, IC; Shin, IS; Shin, NR, 2019) |
| "The purpose of this study is to explore the influence of ozone repeated short exposures on airway/lung inflammation, airway hyperresponsiveness (AHR) and airway hypersecretion in ovalbumin (OVA) sensitized/challenged asthmatic mouse model." | 7.88 | Effects of ozone repeated short exposures on the airway/lung inflammation, airway hyperresponsiveness and mucus production in a mouse model of ovalbumin-induced asthma. ( Bao, A; Bao, W; Fei, X; Zhang, M; Zhang, X; Zhang, Y; Zhou, X, 2018) |
| " This study aimed to evaluate the preventive activity of IMP in an ovalbumin (OVA)-induced murine model of asthma and to investigate its possible molecular mechanisms." | 7.85 | Isoimperatorin attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma. ( Kwon, HJ; Moon, OS; Park, HS; Seo, CS; Son, HY; Song, JW; Wijerathne, CUB; Won, YS, 2017) |
| " In the current study, an ovalbumin (OVA)‑induced allergic asthma model was used to investigate the immune‑modulating effects of pidotimod on airway eosinophilia, mucus metaplasia and inflammatory factor expression compared with dexamethasone (positive control)." | 7.85 | Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma. ( Fu, AK; Fu, LQ; Hu, SL; Li, WF; Li, YL; Wang, YY; Wu, YP, 2017) |
| " After oral administration of indomethacin (5 mg/kg) for 5 consecutive days, gastric ulcerated animals were divided into control group and five other groups: three groups that recieved respectively 125, 250 and 500 mg/kg of plant extract, the fourth group received Maalox (50 mg/kg) and the fifth group, Misoprostol (100 μg/kg), respectively, for 5 days." | 7.85 | Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats. ( Eyoum Bille, B; Kouitcheu Mabeku, LB; Nanfack Nana, B; Nguepi, E; Tchuenteu Tchuenguem, R, 2017) |
| "Repeated inhalation of sevoflurane (SVF) can benefit asthmatic patients by bronchodilation." | 7.81 | Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation. ( Ding, PS; Fang, L; He, F; Liu, RY; Shen, QY; Wu, HM, 2015) |
| "We have reported that triptolide inhibited pulmonary inflammation in patients with steroid-resistant asthma." | 7.81 | Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-κB in a murine model of asthma. ( Chen, M; Huang, L; Jiang, S; Liang, R; Lin, X; Lv, Z; Shi, J; Zhang, W, 2015) |
| "We used ovalbumin (OVA)-based mouse models of asthma and primary CD4(+) T cells." | 7.81 | PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function. ( Al-Ghareeb, K; Al-Khami, AA; Boulares, AH; El-Bahrawy, AH; Ghonim, MA; Ibba, SV; Lammi, MR; Mansy, MS; Naura, AS; Ochoa, A; Pyakurel, K; Rady, HF; Ramsay, A; Rodriguez, P; Wang, J, 2015) |
| "To explore the impact of ozone on the airway hyperresponsinveness (AHR), airway inflammation and mucus production in an allergic asthma mouse model." | 7.81 | [Effects of ozone oxidative stress on the airway hyperresponsiveness and mucus production in mice with acute allergic airway inflammation]. ( Aihua, B; Feng, L; Xin, Z; Yuqing, C; Zhang, M, 2015) |
| "The flavonoid naringenin has been shown to attenuate airway inflammation and airway hyper‑reactivity in acute murine models of asthma." | 7.80 | Naringenin inhibits allergen‑induced airway remodeling in a murine model of asthma. ( Gu, W; Mao, S; Shi, Y; Tan, Y, 2014) |
| "We investigated the suitability of dendritic polyglycerol sulfates (dPGS), conjugated with a hydrophilic version of the indocyanine green label with 6 sulfonate groups (6S-ICG) to monitor sites of inflammation using an experimental mouse model of allergic asthma." | 7.79 | Dendritic polyglycerolsulfate near infrared fluorescent (NIRF) dye conjugate for non-invasively monitoring of inflammation in an allergic asthma mouse model. ( Alves, F; Biffi, S; Bosnjak, B; Dal Monego, S; Dullin, C; Epstein, MM; Garrovo, C; Licha, K; Welker, P, 2013) |
| "Montelukast, a leukotriene receptor antagonist, is used commercially as a maintenance treatment for asthma and to relieve allergic symptoms." | 7.79 | Effects of montelukast on subepithelial/peribronchial fibrosis in a murine model of ovalbumin induced chronic asthma. ( Jeon, WY; Lee, MY; Shin, HK; Shin, IS, 2013) |
| "Verapamil is a useful drug with therapeutic targeting on GCH and a potential way to limit mucous production and improve bronchial inflammation." | 7.78 | Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals. ( Ghafarzadegan, K; Hadi, R; Khakzad, MR; Meshkat, M; Mirsadraee, M; Mohammadpour, A; Saghari, M, 2012) |
| " Female BALB/c mice sensitized and challenged with ovalbumin developed airway inflammation." | 7.78 | Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB. ( Cheng, C; Goh, FY; Guan, S; Leung, BP; Sethi, G; Shanmugam, MK; Upton, N; Wong, WS, 2012) |
| "Evidence suggests that nebulized lidocaine is beneficial in asthma therapy, but to what extent and the mechanisms underlying this effect remain poorly understood." | 7.78 | Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma. ( Anjos-Valotta, EA; Arantes, AC; Cordeiro, RS; Cotias, AC; Couto, GC; Ferreira, TP; Jurgilas, PB; Martins, MA; Olsen, PC; Pão, CR; Pires, AL; Serra, MF; Silva, PM, 2012) |
| "Altered arginine metabolism, the uncoupling of nitric oxide synthase (NOS) by asymmetric dimethyl-arginine (ADMA), increased oxo-nitrosative stress, and cellular injury were reported in airway epithelial cells in asthma." | 7.77 | Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. ( Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A, 2011) |
| "(R)- and (S)-Enantiomers of albuterol likely exert differential effects in patients with asthma." | 7.73 | Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model. ( Banerjee, ER; Chi, EY; Henderson, WR, 2005) |
| "Previous studies have investigated the short-term effect of capsaicin on edema formation and goblet-cell secretion in the trachea." | 7.72 | Spontaneous remission of edema and regranulation of goblet cells in rat tracheae after capsaicin-induced acute inflammation. ( Guo, JJ; Huang, HT; Wang, DS, 2003) |
| "The chronically isoproterenol-treated rat has been proposed as an animal model for cystic fibrosis." | 7.67 | The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland. ( Müller, RM; Roomans, GM, 1984) |
| "Ursolic acid (UA) has activities in immune regulation and anti-inflammatory." | 5.62 | Ursolic Acid Alleviates Mucus Secretion and Tissue Remodeling in Rat Model of Allergic Rhinitis After PM2.5 Exposure. ( Deng, C; Dong, W; Duan, Y; Guo, Z; Han, Z; Sun, N; Wang, H; Zhang, R; Zhao, Q; Zhuang, G, 2021) |
| "The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade." | 5.42 | Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. ( Ahn, KS; Hong, JM; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2015) |
| "Chronic mucosal inflammation is the hallmark of important and common airway diseases, such as allergic rhinitis (AR) and asthma." | 5.42 | Lipoxin B₄ promotes the resolution of allergic inflammation in the upper and lower airways of mice. ( Haworth, O; Karra, L; Levi-Schaffer, F; Levy, BD; Priluck, R, 2015) |
| "Melatonin was administered by intraperitoneal injection once per day at doses of 10 and 15 mg/kg from days 21 to 23 after the initial OVA sensitization." | 5.40 | Melatonin reduces airway inflammation in ovalbumin-induced asthma. ( Ahn, KS; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2014) |
| "Acute bronchiolitis was induced by inhalation of nickel chloride aerosols for 5 days in Wistar rats according to the method described by Kyono et al." | 5.31 | Inflammatory responses and mucus secretion in rats with acute bronchiolitis induced by nickel chloride. ( Ishihara, Y; Kawashima, H; Kyono, H; Miyasaka, M; Serita, F; Toya, T, 2002) |
| "Ovalbumin (OVA) and BaP co-exposure were used to establish the aggravated asthma model." | 4.84 | Qufeng Xuanbi Formula inhibited benzo[a]pyrene-induced aggravated asthma airway mucus secretion by AhR/ROS/ERK pathway. ( Hu, J; Liu, CY; Liu, L; Shi, XL; Sun, XH; Tang, LL; Wang, BH; Wang, Y; Yang, Y; Yu, KY; Zhang, Q; Zhang, XN, 2024) |
| " azedarach fruit extract (MAE) using high-performance liquid chromatography (HPLC) and explored the therapeutic effects of MAE on pulmonary inflammation and mucus hypersecretion using a murine model of ovalbumin (OVA) exposed asthma." | 4.84 | Melia azedarach L. reduces pulmonary inflammation and mucus hypersecretion on a murine model of ovalbumin exposed asthma. ( Kim, T; Kim, WI; Lee, IS; Lee, SJ; Pak, SW; Shin, IS; Yang, YG, 2024) |
| "We demonstrated that intranasal adenosine administration effectively decreased inflammation and mucus production in a mouse model of viral ARS." | 4.31 | Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis. ( Ganama, M; Hua, X; Tilley, S; Varga, SM; Waldstein, KA, 2023) |
| "We established ovalbumin (OVA) induced asthmatic murine model and orally administrated Iristectorigenin A at concentration of 5 and 10 mg/kg and dexamethasone as a positive control substance." | 4.12 | Iristectorigenin A exerts novel protective properties against airway inflammation and mucus hypersecretion in OVA-induced asthmatic mice: Iristectorigenin A ameliorates asthma phenotype. ( Abduwaki, M; Cui, J; Dong, JC; Luo, Q; Lv, Y; Nabijan, M; Nurahmat, M; Qin, J; Tang, W; Teng, F; Wang, S; Wei, Y; Wuniqiemu, T; Zhou, Y; Zhu, X, 2022) |
| " An ovalbumin (OVA)-induced mouse asthma model was established and the effect of acupuncture on airway hyperresponsiveness (AHR), mucus hypersecretion and inflammation was assessed." | 4.02 | TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model. ( Cui, J; Dong, J; Dong, M; Qin, J; Tang, W; Teng, F; Wang, S; Wang, W; Wei, Y; Wuniqiemu, T; Zhu, X, 2021) |
| "Compared with IL 33 group, the inflammatory cell infiltration around the trachea and blood vessels of the lung tissue in the IL 33+ Iloprost group were reduced; goblet cell hyperplasia was observed in airway mucosa of IL 33 group, and the mucus secretion increased; the percentage of EOS and ILC2s in the BALF and lung single cell suspensions in IL 33+ Iloprost group were statistically lower than that of IL 33 group (p < 0." | 3.96 | Iloprost inhibits acute allergic nasal inflammation by GATA3 -ILC2 pathway in mice. ( Jiang, X; Li, L; Liu, H; Liu, J; Liu, K; Yang, C; Zhang, X, 2020) |
| " In this study, we explored the suppressive effects of SAC on allergic airway inflammation induced in an ovalbumin (OVA)-induced asthma mouse model." | 3.91 | S-Allyl cysteine reduces eosinophilic airway inflammation and mucus overproduction on ovalbumin-induced allergic asthma model. ( Kim, JC; Kim, JS; Kim, SH; Ko, JW; Kwon, HJ; Lee, IC; Shin, IS; Shin, NR, 2019) |
| "The purpose of this study is to explore the influence of ozone repeated short exposures on airway/lung inflammation, airway hyperresponsiveness (AHR) and airway hypersecretion in ovalbumin (OVA) sensitized/challenged asthmatic mouse model." | 3.88 | Effects of ozone repeated short exposures on the airway/lung inflammation, airway hyperresponsiveness and mucus production in a mouse model of ovalbumin-induced asthma. ( Bao, A; Bao, W; Fei, X; Zhang, M; Zhang, X; Zhang, Y; Zhou, X, 2018) |
| "NK may be an effective alternative therapeutic option in patients with CRSwNP and comorbid asthma by causing fibrin degradation." | 3.85 | Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus. ( Fujieda, S; Imoto, Y; Ishizuka, T; Kato, Y; Narita, N; Sakashita, M; Takabayashi, T; Tokunaga, T; Yoshida, K, 2017) |
| " This study aimed to evaluate the preventive activity of IMP in an ovalbumin (OVA)-induced murine model of asthma and to investigate its possible molecular mechanisms." | 3.85 | Isoimperatorin attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma. ( Kwon, HJ; Moon, OS; Park, HS; Seo, CS; Son, HY; Song, JW; Wijerathne, CUB; Won, YS, 2017) |
| " This study evaluates whether intranasally delivered gas-filled microbubble (MB)-associated ovalbumin (OVA), used as a model allergen, can serve as a therapeutic treatment in a mouse model of established allergic asthma." | 3.85 | Therapeutic intranasal instillation of allergen-loaded microbubbles suppresses experimental allergic asthma in mice. ( Bioley, G; Corthésy, B, 2017) |
| " In the current study, an ovalbumin (OVA)‑induced allergic asthma model was used to investigate the immune‑modulating effects of pidotimod on airway eosinophilia, mucus metaplasia and inflammatory factor expression compared with dexamethasone (positive control)." | 3.85 | Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma. ( Fu, AK; Fu, LQ; Hu, SL; Li, WF; Li, YL; Wang, YY; Wu, YP, 2017) |
| " After oral administration of indomethacin (5 mg/kg) for 5 consecutive days, gastric ulcerated animals were divided into control group and five other groups: three groups that recieved respectively 125, 250 and 500 mg/kg of plant extract, the fourth group received Maalox (50 mg/kg) and the fifth group, Misoprostol (100 μg/kg), respectively, for 5 days." | 3.85 | Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats. ( Eyoum Bille, B; Kouitcheu Mabeku, LB; Nanfack Nana, B; Nguepi, E; Tchuenteu Tchuenguem, R, 2017) |
| " In addition, to investigate the effects of CuONPs on asthma development, we used a murine model of ovalbumin (OVA)-induced asthma." | 3.83 | Copper oxide nanoparticles aggravate airway inflammation and mucus production in asthmatic mice via MAPK signaling. ( Ahn, KS; Jeon, CM; Kim, JC; Ko, JW; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2016) |
| " This study aimed to determine the possible effects and underlying mechanisms of Suhuang on chronic ovalbumin (OVA)-induced airway hyperresponsiveness (AHR), inflammation, and remodeling in mice." | 3.83 | Suhuang antitussive capsule at lower doses attenuates airway hyperresponsiveness, inflammation, and remodeling in a murine model of chronic asthma. ( Che, LQ; Chen, ZH; Lai, TW; Li, W; Shen, HH; Wang, HS; Wu, YF; Xiao, H; Ying, SM; Zhang, C; Zhang, LH, 2016) |
| "Repeated inhalation of sevoflurane (SVF) can benefit asthmatic patients by bronchodilation." | 3.81 | Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation. ( Ding, PS; Fang, L; He, F; Liu, RY; Shen, QY; Wu, HM, 2015) |
| "We have reported that triptolide inhibited pulmonary inflammation in patients with steroid-resistant asthma." | 3.81 | Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-κB in a murine model of asthma. ( Chen, M; Huang, L; Jiang, S; Liang, R; Lin, X; Lv, Z; Shi, J; Zhang, W, 2015) |
| "We used ovalbumin (OVA)-based mouse models of asthma and primary CD4(+) T cells." | 3.81 | PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function. ( Al-Ghareeb, K; Al-Khami, AA; Boulares, AH; El-Bahrawy, AH; Ghonim, MA; Ibba, SV; Lammi, MR; Mansy, MS; Naura, AS; Ochoa, A; Pyakurel, K; Rady, HF; Ramsay, A; Rodriguez, P; Wang, J, 2015) |
| "To explore the impact of ozone on the airway hyperresponsinveness (AHR), airway inflammation and mucus production in an allergic asthma mouse model." | 3.81 | [Effects of ozone oxidative stress on the airway hyperresponsiveness and mucus production in mice with acute allergic airway inflammation]. ( Aihua, B; Feng, L; Xin, Z; Yuqing, C; Zhang, M, 2015) |
| "The flavonoid naringenin has been shown to attenuate airway inflammation and airway hyper‑reactivity in acute murine models of asthma." | 3.80 | Naringenin inhibits allergen‑induced airway remodeling in a murine model of asthma. ( Gu, W; Mao, S; Shi, Y; Tan, Y, 2014) |
| " In this study, we investigated the protective effects of SG extract on allergic asthma in an ovalbumin (OVA)-induced asthma murine model and lipopolysaccharide (LPS)-stimulated RAW264." | 3.80 | Siegesbeckia glabrescens attenuates allergic airway inflammation in LPS-stimulated RAW 264.7 cells and OVA induced asthma murine model. ( Ahn, KS; Hong, JM; Jeon, CM; Kim, HS; Kwon, OK; Myung, PK; Oh, SR; Shin, IS; Shin, NR, 2014) |
| "We investigated the suitability of dendritic polyglycerol sulfates (dPGS), conjugated with a hydrophilic version of the indocyanine green label with 6 sulfonate groups (6S-ICG) to monitor sites of inflammation using an experimental mouse model of allergic asthma." | 3.79 | Dendritic polyglycerolsulfate near infrared fluorescent (NIRF) dye conjugate for non-invasively monitoring of inflammation in an allergic asthma mouse model. ( Alves, F; Biffi, S; Bosnjak, B; Dal Monego, S; Dullin, C; Epstein, MM; Garrovo, C; Licha, K; Welker, P, 2013) |
| "In the OVA-exposed mice for 6 wks inflammatory cells infiltration, levels of inflammatory cytokines and chemokines, goblet cell metaplasia, collagen deposition and AHR were significantly decreased by treatment with AR inhibitor, fidarestat." | 3.79 | Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice. ( Aguilera-Aguirre, L; Boldogh, I; Boulares, HA; Calhoun, WJ; Naura, AS; Ramana, KV; Srivastava, SK; Yadav, UC, 2013) |
| "Montelukast, a leukotriene receptor antagonist, is used commercially as a maintenance treatment for asthma and to relieve allergic symptoms." | 3.79 | Effects of montelukast on subepithelial/peribronchial fibrosis in a murine model of ovalbumin induced chronic asthma. ( Jeon, WY; Lee, MY; Shin, HK; Shin, IS, 2013) |
| "Verapamil is a useful drug with therapeutic targeting on GCH and a potential way to limit mucous production and improve bronchial inflammation." | 3.78 | Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals. ( Ghafarzadegan, K; Hadi, R; Khakzad, MR; Meshkat, M; Mirsadraee, M; Mohammadpour, A; Saghari, M, 2012) |
| " Female BALB/c mice sensitized and challenged with ovalbumin developed airway inflammation." | 3.78 | Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB. ( Cheng, C; Goh, FY; Guan, S; Leung, BP; Sethi, G; Shanmugam, MK; Upton, N; Wong, WS, 2012) |
| "The preventive and healing properties of Croton urucurana bark methanol extract (CUE) were evaluated in experimental models of acute (ethanol and indomethacin) and chronic (acetic acid) gastric ulcers." | 3.78 | Antiulcerogenic effect of Croton urucurana Baillon bark. ( Aparecida Pinto, L; de Cássia Freitas, K; Faloni de Andrade, S; Leite Kassuya, CA; Nazari Formagio, AS; Wolff Cordeiro, K, 2012) |
| "Evidence suggests that nebulized lidocaine is beneficial in asthma therapy, but to what extent and the mechanisms underlying this effect remain poorly understood." | 3.78 | Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma. ( Anjos-Valotta, EA; Arantes, AC; Cordeiro, RS; Cotias, AC; Couto, GC; Ferreira, TP; Jurgilas, PB; Martins, MA; Olsen, PC; Pão, CR; Pires, AL; Serra, MF; Silva, PM, 2012) |
| " They were subjected to the absolute ethanol- and indomethacin-induced gastric ulcer, and pyloric ligation assays after 30 min." | 3.78 | Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf. ( Hamid, HA; Hisam, EE; Mohtaruddin, N; Othman, F; Rofiee, MS; Zakaria, ZA, 2012) |
| "Altered arginine metabolism, the uncoupling of nitric oxide synthase (NOS) by asymmetric dimethyl-arginine (ADMA), increased oxo-nitrosative stress, and cellular injury were reported in airway epithelial cells in asthma." | 3.77 | Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. ( Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A, 2011) |
| " The acetic acid-induced gastric ulcer model and Western Blot assay (COX-2 and EGF) were also used to evaluate the OEH healing capacity." | 3.77 | Gastroprotective and ulcer healing effects of essential oil from Hyptis spicigera Lam. (Lamiaceae). ( de Almeida, AC; de-Faria, FM; Dunder, RJ; Hiruma-Lima, CA; Luiz-Ferreira, A; Manzo, LP; Pellizzon, CH; Rehen, CS; Rozza, AL; Salvador, MJ; Socca, EA; Souza-Brito, AR; Takayama, C; Valim-Araújo, Dde A, 2011) |
| "The effect of PET was investigated in ovalbumin (OVA) immunized BALB/c mice given intranasally together with antigen challenge in the murine model of allergic airway disease (asthma) with the analysis of the inflammatory and immune parameters in the lung." | 3.76 | Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice. ( Brattström, A; Maillet, I; Moser, R; Ryffel, B; Schapowal, A; Schnyder, B, 2010) |
| "ITE obtained from leaves by supercritical carbon dioxide extraction was investigated in ovalbumin (OVA) immunised BALB/c mice given intranasally together with antigen challenge in the murine model of allergic airway disease (asthma) with the analysis of the inflammatory and immune parameters in the lung." | 3.76 | The plant extract Isatis tinctoria L. extract (ITE) inhibits allergen-induced airway inflammation and hyperreactivity in mice. ( Brattström, A; Kamal, MA; Maillet, I; Moser, R; Ryffel, B; Schapowal, A, 2010) |
| " Pretreatment with Cyclea peltata extract provided significant protection against the peptic ulceration caused by ethanol administered individually, or in combination with indomethacin." | 3.75 | Gastric antisecretory and antiulcer activities of Cyclea peltata (Lam.) Hook. f. & Thoms. in rats. ( Anuja, GI; Latha, PG; Pradeep, S; Rajasekharan, S; Shine, VJ; Shyamal, S; Sini, S; Suja, SR, 2009) |
| ") inhibited the number of coughs induced by capsaicin aerosol (P<0." | 3.74 | Novel triple neurokinin receptor antagonist CS-003 inhibits respiratory disease models in guinea pigs. ( Kuraya, T; Morimoto, K; Nosaka, E; Takahashi, S; Tsuchida, H; Yamashita, M, 2008) |
| " In order to investigate the pharmacological effects of kefir, we used a mouse asthma model, in which airway inflammation and airway remodeling was produced by ovalbumin sensitization and challenge." | 3.74 | Anti-inflammatory and anti-allergic effects of kefir in a mouse asthma model. ( Ahn, KS; Kim, MJ; Kim, MK; Kwon, OK; Lee, HK; Lee, IY; Lee, MY; Oh, SR, 2007) |
| " The extract at 400 mg/kg body weight, once daily, orally has a significant effect in cold restraint (CRU, 2 h cold restraint stress), aspirin (ASA, 150 mg/kg body weight, orally), alcohol (AL, 1 ml/200 gm of absolute alcohol) and pyloric ligation (PL, 4h ligation) induced gastric ulcer models as it showed protection index of 71." | 3.73 | Allophylus serratus: a plant with potential anti-ulcerogenic activity. ( Dharmani, P; Maurya, R; Mishra, PK; Palit, G; Singh Chauhan, V, 2005) |
| "(R)- and (S)-Enantiomers of albuterol likely exert differential effects in patients with asthma." | 3.73 | Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model. ( Banerjee, ER; Chi, EY; Henderson, WR, 2005) |
| "Twenty-four BALB/c mice were randomly divided into 3 equal groups: asthma group [ovalbumin (OVA) and aluminum hydroxide were injected intraperitoneally on day 0 and day 14 so as to establish mouse asthma model and aerosol inhalation of OVA PBS was conducted for 30 min on the days 21, 22, and 24], asthma + dexamethasone group (OVA and aluminum hydroxide were injected intraperitoneally on days 0 and 14, aerosol inhalation of OVA PBS was conducted for 30 min on the days 21, 22, and 24, and dexamethasone was injected intraperitoneally 1 hour before the aerosol inhalation), and control group (aerosol inhalation of PBS was conducted instead)." | 3.73 | [Effects of glucocorticoid on airway mucus secretion in asthma: experiment with asthmatic mouse model]. ( Liu, JB; Xing, LH; Xu, YJ; Zhang, HL; Zhang, ZX, 2006) |
| "Previous studies have investigated the short-term effect of capsaicin on edema formation and goblet-cell secretion in the trachea." | 3.72 | Spontaneous remission of edema and regranulation of goblet cells in rat tracheae after capsaicin-induced acute inflammation. ( Guo, JJ; Huang, HT; Wang, DS, 2003) |
| " To clarify the effects of DE on the exacerbation of asthma, guinea pigs were exposed 12 h daily to 3 mg/m(3) DE or air for 8 wk with or without sensitization to ovalbumin (OVA)." | 3.71 | Exposure to diesel exhaust exacerbates allergen-induced airway responses in guinea pigs. ( Hashimoto, K; Hirano, K; Ishii, Y; Kimura, T; Masuyama, K; Morishima, Y; Nomura, A; Sagai, M; Sakamoto, T; Sekizawa, K; Takano, H; Uchida, Y, 2001) |
| "To evaluate the effects of teprenone on acute gastritis, its inhibitory effects on gastric mucosal damage were compared to that of gefarnate in taurocholate/hydrochloric acid-induced acute gastric mucosal lesions in rats." | 3.70 | [Protective effects of teprenone and gefarnate against taurocholate/hydrochloric acid-induced acute gastric mucosal lesions in rats]. ( Katoh, Y; Kawashima, H; Tanaka, M, 1998) |
| "The ovalbumin-sensitized guinea pig is commonly used as a small animal model of allergic asthma." | 3.69 | Effect of dexamethasone on antigen-induced high molecular weight glycoconjugate secretion in allergic guinea pigs. ( Boulet, L; Chan, CC; Plant, M; Pon, DJ; Rodger, IW; Savoie, C; van Staden, CJ; Zwikker, M, 1995) |
| "The chronically isoproterenol-treated rat has been proposed as an animal model for cystic fibrosis." | 3.67 | The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland. ( Müller, RM; Roomans, GM, 1984) |
| "Chronic treatment of rats with reserpine, isoproterenol, or a combination of these two agents has been suggested as a means to produce an experimental animal model for the chronic exocrinopathy cystic fibrosis." | 3.67 | Changes in glycoconjugates in rat submandibular gland after chronic treatment with reserpine and isoproterenol. ( Maltarello, MC; Müller, RM; Roomans, GM; Versura, P, 1988) |
| "In three models of cholelithiasis (dihydrocholesterol-fed rabbits, cholesterol-cholic acid-fed mice, and Lincomycin-treated guinea pigs), the quantity and chemical composition of gallbladder epithelial mucin have been studied using (1) a spectrum of histochemical glycoprotein stains, and (2) biochemical extraction, purification and analysis of the carbohydrate components of epithelial mucin." | 3.66 | Hypersecretion of mucus glycoprotein by the gallbladder epithelium in experimental cholelithiasis. ( Lee, SP, 1981) |
| "Human patients with active ulcerative colitis have this layer penetrable to bacteria and beads the size of bacteria." | 2.49 | Mucus and the goblet cell. ( Hansson, GC; Johansson, ME, 2013) |
| "Current therapeutics for ulcerative colitis (UC) have limitations." | 1.91 | Modified Gegen Qinlian decoction ameliorates DSS-induced chronic colitis in mice by restoring the intestinal mucus barrier and inhibiting the activation of γδT17 cells. ( Huang, J; Liu, Z; Ma, J; Tang, X; Wang, F; Wang, Y; Yang, X; Zhang, J, 2023) |
| "IL-13 develops bronchial asthma by elevating bronchial hyperresponsiveness and enables production of immunoglobulin M (IgM) and IgE." | 1.72 | High throughput virtual screening strategy to develop a potential treatment for bronchial asthma by targeting interleukin 13 cytokine signaling. ( Jing, J; Ma, Q; Tong, H, 2022) |
| "Ursolic acid (UA) has activities in immune regulation and anti-inflammatory." | 1.62 | Ursolic Acid Alleviates Mucus Secretion and Tissue Remodeling in Rat Model of Allergic Rhinitis After PM2.5 Exposure. ( Deng, C; Dong, W; Duan, Y; Guo, Z; Han, Z; Sun, N; Wang, H; Zhang, R; Zhao, Q; Zhuang, G, 2021) |
| "Tectochrysin treatment reduced the level of IgE in plasma, the percentage of eosinophils in total white blood cells in peripheral blood, the total number of cells in BAL fluid, and eosinophil peroxidase activity in lung tissues." | 1.62 | Tectochrysin ameliorates murine allergic airway inflammation by suppressing Th2 response and oxidative stress. ( Fang, L; He, Z; Jiang, X; Wu, F; Xu, Z; Yan, Y; Yu, D; Yuan, X; Zhang, T; Zhou, S, 2021) |
| "Pretreatment with diminazene aceturate, a small molecule with ability to inhibit acid detection through blockade of the acid-sensing ion channel (ASIC) at the doses provided, did not prevent acid-induced pathologic mucus or transport defects but did mitigate airway obstruction." | 1.56 | Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways. ( Atanasova, KR; Bravo, L; Collins, EN; Dadural, JS; Eken, E; Guevara, MV; Kuan, SP; Liao, YSJ; Reznikov, LR; Schurmann, V; Sponchiado, M; Vogt, K, 2020) |
| "Dithiothreitol and P3001 were directly compared with NAC in vitro and both exhibited superior reducing activities." | 1.51 | An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases. ( Boucher, RC; Delion, MF; Donaldson, SH; Ehre, C; Esther, CR; Fontana, NC; Grubb, BR; Hill, DB; Hothem, LN; Kato, T; Livraghi-Butrico, A; Markovetz, MR; Morrison, CB; Rushton, ZL; Thelin, WR; Villalon, D; Wang, B, 2019) |
| "Chronic obstructive pulmonary disease (COPD) is a chronic, progressive and lethal lung disease with few treatments." | 1.48 | Limax extract ameliorates cigarette smoke-induced chronic obstructive pulmonary disease in mice. ( Guan, R; Li, D; Liang, X; Long, Z; Lu, W; Wang, J; Wang, Z; Xie, J; Xu, J; Yang, Q; Zhao, L, 2018) |
| "Phloretin pretreatment dramatically suppressed the mucins secretion, inflammatory cell infiltration and inflammatory cytokine release in mouse lungs induced by CS, and it also suppressed CSE-induced expression of MUC5AC and IL-1β in NCI-H292 bronchial epithelial cells." | 1.48 | Phloretin attenuates mucus hypersecretion and airway inflammation induced by cigarette smoke. ( Chen, L; Hao, N; Shen, Y; Wang, H; Wang, T; Wen, F; Wu, Y; Yang, T; Yuan, Z, 2018) |
| "Chronic colitis was induced in C57BL/6 mice by administration of dextran sulfate sodium (DSS) for 27 days." | 1.48 | Peroxisome proliferator-activated receptor gamma activation promotes intestinal barrier function by improving mucus and tight junctions in a mouse colitis model. ( Cheng, L; Yang, J; Zhao, J; Zhao, R; Zhu, L, 2018) |
| "TAS2R agonists attenuated features of airway remodeling including smooth muscle mass, extracellular matrix deposition and pro-fibrotic signaling, and also prevented mucus accumulation and development of AHR in mice." | 1.46 | Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice. ( Deshpande, DA; Knight, MJ; Nayak, AP; Oliver, B; Pan, S; Sharma, P; Tang, F; Wang, N; Yi, R, 2017) |
| "Sprague-Dawley rats were made chronic obstructive pulmonary disease models via tobacco smoke exposure for 12 weeks and the rats were treated with 10 ml/kg hydrogen-rich saline intraperitoneally during the last 4 weeks." | 1.46 | Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats. ( Geng, W; Jiang, C; Li, C; Liu, Y; Liu, Z; Qin, S; Si, Y; Zhang, X; Zhang, Y; Zhao, S, 2017) |
| "The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade." | 1.42 | Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. ( Ahn, KS; Hong, JM; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2015) |
| "Chronic mucosal inflammation is the hallmark of important and common airway diseases, such as allergic rhinitis (AR) and asthma." | 1.42 | Lipoxin B₄ promotes the resolution of allergic inflammation in the upper and lower airways of mice. ( Haworth, O; Karra, L; Levi-Schaffer, F; Levy, BD; Priluck, R, 2015) |
| "We used a murine model of respiratory allergy to the mite Blomia tropicalis (Bt) and evaluated certain parameters known to be altered in this model." | 1.42 | The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. ( Alcântara-Neves, NM; Alves de Souza, S; da Silva Velozo, E; Ferreira Silva, HB; Figueiredo, CA; Meneses Souza, FL; Pires de Oliveira, A; Pontes-de-Carvalho, LC; Rios, R; Santos Alves, W; Santos Costa, R; Santos Serafim Machado, M; Sarmento Silva, TM; Silva, ML; Vilany Queiroz Carneiro, N, 2015) |
| "Pretreatment with carvedilol attenuated LPO elevation, mucus content and sulfhydryl group inhibitions." | 1.42 | Carvedilol attenuates inflammatory biomarkers and oxidative stress in a rat model of ulcerative colitis. ( Abuohashish, HM; Ahmed, MM; Al-Hosaini, KA; Al-Rejaie, SS; Fatani, AJ; Parmar, MY, 2015) |
| "(CJT) on the development of COPD using a Cigarette smoke (CS)-induced murine model and cigarette smoke condensate (CSC)-stimulated H292 cells, human pulmonary mucoepidermoid cell line." | 1.42 | Callicarpa japonica Thunb. attenuates cigarette smoke-induced neutrophil inflammation and mucus secretion. ( Ahn, KS; Hee Kim, J; Kwon, OK; Lee, HJ; Lee, HS; Lee, J; Lee, JW; Oh, SR; Park, JW; Park, SY; Shin, NR; Zhang, ZY, 2015) |
| "Mucoobstructive lung diseases have highlighted the importance of a proper description of the normal mucus clearance system." | 1.42 | On the Pathogenesis of Acute Exacerbations of Mucoobstructive Lung Diseases. ( Boucher, RC, 2015) |
| "Chlamydia infections are common causes of respiratory disease, particularly pneumonia in neonates, and are linked to permanent reductions in pulmonary function and the induction of asthma." | 1.40 | Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease. ( Collison, AM; Essilfie, AT; Foster, PS; Hansbro, PM; Hatchwell, LM; Horvat, JC; Kim, RY; Mattes, J; Nguyen, DH; Starkey, MR; Yagita, H, 2014) |
| "Melatonin was administered by intraperitoneal injection once per day at doses of 10 and 15 mg/kg from days 21 to 23 after the initial OVA sensitization." | 1.40 | Melatonin reduces airway inflammation in ovalbumin-induced asthma. ( Ahn, KS; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2014) |
| "Mycobacterium avium subsp." | 1.39 | Divergent immune responses to Mycobacterium avium subsp. paratuberculosis infection correlate with kinome responses at the site of intestinal infection. ( Griebel, P; Kusalik, A; Määttänen, P; Napper, S; Potter, A; Scruten, E; Trost, B, 2013) |
| " At the same dosing levels, no significant differences in FA were observed in mice pretreated with strains with similar adhesive abilities but different antagonistic activities." | 1.39 | Alleviating effects of Lactobacillus strains on pathogenic Vibrio parahaemolyticus-induced intestinal fluid accumulation in the mouse model. ( Fang, WM; Gao, L; Gu, RX; Jiao, XA; Jin, CJ; Qian, JY; Yang, ZQ, 2013) |
| " Colon-targeted, intraluminal delivery of 5-HT(4)R agonists might be used to promote motility and alleviate visceral pain, while restricting systemic bioavailability and resulting adverse side effects." | 1.38 | Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity. ( Balemba, OB; Brooks, EM; Galligan, JJ; Greenwood-Van Meerveld, B; Hoffman, JM; Johnson, AC; MacEachern, SJ; Mawe, GM; Moses, PL; Sharkey, KA; Swain, GM; Tyler, K; Zhao, H, 2012) |
| "Pre-treatment with arbutin or omeprazole protected the gastric mucosa as seen by reduction in ulcer area and mucosal content, reduced or absence of edema, inflammation and leucocytes infiltration on both models." | 1.38 | Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin. ( Abdelwahab, SI; Abdulla, MA; Ali, HM; Hadi, AH; Salga, MS; Taha, MM, 2012) |
| " The current study compared three rat models induced by cigarette smoke (CS) exposure alone or combined with pre- or post-treatment with lipopolysaccharide (LPS)." | 1.38 | Characteristic comparison of three rat models induced by cigarette smoke or combined with LPS: to establish a suitable model for study of airway mucus hypersecretion in chronic obstructive pulmonary disease. ( Li, PB; Luo, YL; Nie, YC; Shen, JG; Su, WW; Wu, H; Zhang, CC, 2012) |
| "Inflammation was induced by sensitization and chronic exposure of 16 C57BL/6 mice to Aspergillus fumigatus." | 1.38 | In vivo determination of mouse olfactory mucus cation concentrations in normal and inflammatory states. ( Conley, DB; Epstein, VA; Kern, RC; Liu, K; Richter, CP; Robinson, AM; Selvaraj, S, 2012) |
| "Inflammation was assessed by the total and differential cell counts and IL-4 and IL-5 levels in bronchoalveolar lavage (BAL) fluid." | 1.38 | The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma. ( Daubeuf, F; Frossard, N; Nemska, S; Reber, LL, 2012) |
| "The most striking difference in the pulmonary inflammation induced in A(2B) receptor knockout (A(2B)KO) and wild-type mice was the lack of allergen-induced IL-4 release in the airways of A(2B)KO animals, in line with a significant reduction in IL-4 protein and mRNA levels in lung tissue." | 1.36 | Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice. ( Biaggioni, I; Blackburn, MR; Feoktistov, I; Goldstein, AE; Goleniewska, K; Mitchell, D; Morschl, E; Newcomb, DC; Novitskiy, SV; Peebles, RS; Polosukhin, VV; Ryzhov, S; Yin, H; Zaynagetdinov, R; Zhou, Y, 2010) |
| " Because we have previously described that arginase affects NOx content and interferes with the activation of NF-kappaB in lung epithelial cells, the goal of this study was to investigate the impact of arginase inhibition on the bioavailability of NO and the implications for NF-kappaB activation and inflammation in a mouse model of allergic airway disease." | 1.35 | Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. ( Ckless, K; Irvin, CG; Janssen-Heininger, YM; Kasahara, D; Lampert, A; Lundblad, LK; Norton, R; Poynter, ME; Reiss, J; van der Vliet, A, 2008) |
| "In both asthma and COPD mouse models, pendrin was up-regulated at the apical side of airway epithelial cells in association with mucus overproduction." | 1.35 | Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease. ( Aizawa, H; Arima, K; Fukuda, T; Green, ED; Hasegawa, M; Hayashi, H; Hoshino, T; Inoue, H; Inoue, M; Izuhara, K; Kanaji, S; Kubo, H; Matsushita, H; Nagai, H; Nakao, I; Nakayama, K; Ohta, S; Okinami, S; Sagara, H; Shiraki, A; Sugiyama, K; Suzuki, K; Tanaka, H; Toda, S; Watanabe, M; Yamaya, M; Yuyama, N, 2008) |
| "Airway eosinophilia was observed during both responses." | 1.33 | Effect of disodium cromoglycate on airway mucus secretion during antigen-induced late asthmatic responses in a murine model of asthma. ( Arakawa, H; Koyama, H; Mayuzumi, H; Mizuno, T; Mochizuki, H; Morikawa, A; Nishimura, H; Ohki, Y; Tokuyama, K, 2005) |
| "Human bronchial asthma is characterized by airway hyperresponsiveness (AHR), eosinophilic airway inflammation, mucus hypersecretion and high serum level of IgE." | 1.33 | Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness. ( Ishikawa, Y; Nakanishi, K; Yoshimoto, T, 2006) |
| "This strategy resulted in a pulmonary eosinophilia equivalent to that observed in OVA-treated wild-type animals." | 1.32 | A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse. ( Ansay, TL; Biechelle, TL; Borchers, MT; Colbert, DC; Cormier, SA; Crosby, JR; Hines, EM; Justice, JP; Lee, JJ; Lee, NA; McGarry, MP; O'Neill, KR; Ochkur, SI; Shen, HH; Wang, H, 2003) |
| " It has not been determined whether rib cage compression combined with endotracheal suctioning improves oxygenation, ventilation, and mucus clearance." | 1.32 | Effects of expiratory rib cage compression combined with endotracheal suctioning on gas exchange in mechanically ventilated rabbits with induced atelectasis. ( Mizutani, T; Toyooka, H; Unoki, T, 2004) |
| "Acute bronchiolitis was induced by inhalation of nickel chloride aerosols for 5 days in Wistar rats according to the method described by Kyono et al." | 1.31 | Inflammatory responses and mucus secretion in rats with acute bronchiolitis induced by nickel chloride. ( Ishihara, Y; Kawashima, H; Kyono, H; Miyasaka, M; Serita, F; Toya, T, 2002) |
| "Pretreatment with glycine significantly protected animals against stress-, indomethacin- and necrotizing agents induced gastric lesions." | 1.30 | Studies on the antisecretory, gastric anti-ulcer and cytoprotective properties of glycine. ( Al Moutaery, AR; Tariq, M, 1997) |
| "A streptomycin-treated mouse model was used to compare the intestinal colonizing capacity of E." | 1.28 | Mouse model for colonization and disease caused by enterohemorrhagic Escherichia coli O157:H7. ( Burris, JA; O'Brien, AD; Wadolkowski, EA, 1990) |
| " Thus a stimulation of the mucociliary transport rate by the other major pharmacodynamic mechanisms, secretagogue activity and stimulation of pulmonary surfactant, has to be considered." | 1.27 | Pharmacodynamic mechanism and therapeutic activity of ambroxol in animal experiments. ( Disse, BG; Ziegler, HW, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (7.79) | 18.7374 |
| 1990's | 24 (6.03) | 18.2507 |
| 2000's | 92 (23.12) | 29.6817 |
| 2010's | 196 (49.25) | 24.3611 |
| 2020's | 55 (13.82) | 2.80 |
| Authors | Studies |
|---|---|
| Kuang, Y | 1 |
| Li, B | 1 |
| Fan, J | 1 |
| Qiao, X | 1 |
| Ye, M | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 6 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Ma, Q | 1 |
| Tong, H | 2 |
| Jing, J | 1 |
| Lim, JO | 1 |
| Lee, SJ | 2 |
| Kim, WI | 2 |
| Pak, SW | 2 |
| Moon, C | 1 |
| Shin, IS | 10 |
| Heo, JD | 1 |
| Ko, JW | 3 |
| Kim, JC | 5 |
| Du, X | 1 |
| Yang, Y | 3 |
| Yang, M | 1 |
| Yuan, L | 1 |
| Wang, L | 4 |
| Wu, M | 6 |
| Zhou, K | 1 |
| Xiang, Y | 2 |
| Qu, X | 2 |
| Liu, H | 4 |
| Qin, X | 2 |
| Liu, C | 5 |
| Yu, W | 1 |
| Moninger, TO | 2 |
| Thurman, AL | 1 |
| Xie, Y | 2 |
| Jain, A | 1 |
| Zarei, K | 1 |
| Powers, LS | 1 |
| Pezzulo, AA | 3 |
| Stoltz, DA | 5 |
| Welsh, MJ | 4 |
| Wu, D | 2 |
| Jiang, W | 1 |
| Liu, L | 4 |
| Li, F | 2 |
| Ma, X | 1 |
| Pan, L | 1 |
| Ousingsawat, J | 1 |
| Centeio, R | 1 |
| Cabrita, I | 2 |
| Talbi, K | 1 |
| Zimmer, O | 1 |
| Graf, M | 1 |
| Göpferich, A | 1 |
| Schreiber, R | 2 |
| Kunzelmann, K | 2 |
| Singanayagam, A | 1 |
| Footitt, J | 1 |
| Marczynski, M | 1 |
| Radicioni, G | 1 |
| Cross, MT | 1 |
| Finney, LJ | 1 |
| Trujillo-Torralbo, MB | 1 |
| Calderazzo, M | 1 |
| Zhu, J | 2 |
| Aniscenko, J | 2 |
| Clarke, TB | 1 |
| Molyneaux, PL | 1 |
| Bartlett, NW | 2 |
| Moffatt, MF | 1 |
| Cookson, WO | 1 |
| Wedzicha, J | 1 |
| Evans, CM | 3 |
| Boucher, RC | 11 |
| Kesimer, M | 1 |
| Lieleg, O | 1 |
| Mallia, P | 1 |
| Johnston, SL | 2 |
| Fang, J | 1 |
| Zhang, Z | 2 |
| Cheng, Y | 1 |
| Yang, H | 2 |
| Zhang, H | 4 |
| Xue, Z | 1 |
| Lu, S | 2 |
| Dong, Y | 1 |
| Song, C | 1 |
| Zhang, X | 7 |
| Zhou, Y | 4 |
| Mann, TS | 1 |
| Larcombe, AN | 1 |
| Wang, KCW | 1 |
| Shamsuddin, D | 1 |
| Landwehr, KR | 1 |
| Noble, PB | 1 |
| Henry, PJ | 1 |
| Wuniqiemu, T | 2 |
| Teng, F | 2 |
| Qin, J | 2 |
| Lv, Y | 1 |
| Nabijan, M | 1 |
| Luo, Q | 1 |
| Cui, J | 2 |
| Tang, W | 2 |
| Zhu, X | 3 |
| Wang, S | 4 |
| Abduwaki, M | 1 |
| Nurahmat, M | 1 |
| Wei, Y | 2 |
| Dong, JC | 1 |
| Wu, Z | 1 |
| Liu, X | 3 |
| Huang, S | 2 |
| Li, T | 1 |
| Pang, J | 1 |
| Zhao, J | 3 |
| Chen, L | 3 |
| Zhang, B | 1 |
| Wang, J | 3 |
| Han, D | 1 |
| Eddie, AM | 1 |
| Chen, KW | 1 |
| Schenkel, LB | 1 |
| Swinger, KK | 1 |
| Molina, JR | 1 |
| Kunii, K | 1 |
| Raybuck, AL | 1 |
| Keilhack, H | 1 |
| Gibson-Corley, KN | 1 |
| Niepel, M | 1 |
| Peebles, RS | 2 |
| Boothby, MR | 1 |
| Cho, SH | 1 |
| Zhi, W | 1 |
| Jiang, S | 2 |
| Xu, Z | 2 |
| An, Y | 1 |
| Chen, J | 1 |
| Li, Y | 8 |
| Liu, Y | 6 |
| Lu, X | 1 |
| Tan, ZX | 1 |
| Wang, WJ | 1 |
| Zhan, P | 1 |
| Wang, Y | 6 |
| Fu, L | 1 |
| Gao, L | 2 |
| Zhao, H | 3 |
| Wang, H | 6 |
| Xu, DX | 1 |
| Waldstein, KA | 1 |
| Ganama, M | 1 |
| Varga, SM | 1 |
| Tilley, S | 1 |
| Hua, X | 1 |
| Ma, J | 2 |
| Zhang, J | 2 |
| Huang, J | 1 |
| Yang, X | 4 |
| Liu, Z | 4 |
| Wang, F | 1 |
| Tang, X | 1 |
| Fang, YX | 1 |
| Liu, YQ | 1 |
| Hu, YM | 1 |
| Yang, YY | 1 |
| Zhang, DJ | 1 |
| Jiang, CH | 1 |
| Wang, JH | 1 |
| Wang, Q | 2 |
| Xu, K | 1 |
| Cai, X | 1 |
| Wang, C | 2 |
| Cao, Y | 1 |
| Xiao, J | 1 |
| Briata, P | 1 |
| Mastracci, L | 1 |
| Zapparoli, E | 1 |
| Caputo, L | 1 |
| Ferracci, E | 1 |
| Silvestri, A | 1 |
| Garuti, A | 1 |
| Hamadou, MH | 1 |
| Inga, A | 1 |
| Marcaccini, E | 1 |
| Grillo, F | 1 |
| Bucci, G | 1 |
| Puri, PL | 1 |
| Beznoussenko, G | 1 |
| Mironov, A | 1 |
| Chiacchiera, F | 1 |
| Gherzi, R | 1 |
| Homolak, J | 1 |
| De Busscher, J | 1 |
| Zambrano-Lucio, M | 1 |
| Joja, M | 1 |
| Virag, D | 1 |
| Babic Perhoc, A | 1 |
| Knezovic, A | 1 |
| Osmanovic Barilar, J | 1 |
| Salkovic-Petrisic, M | 1 |
| Hou, Y | 1 |
| Zheng, S | 1 |
| Zou, F | 1 |
| Wang, D | 2 |
| Da, H | 1 |
| Fan, X | 2 |
| Liu, J | 2 |
| He, J | 1 |
| Li, H | 3 |
| Sun, X | 1 |
| Wang, BH | 1 |
| Tang, LL | 1 |
| Sun, XH | 1 |
| Zhang, Q | 1 |
| Liu, CY | 1 |
| Zhang, XN | 1 |
| Yu, KY | 1 |
| Hu, J | 3 |
| Shi, XL | 1 |
| Lee, IS | 1 |
| Yang, YG | 1 |
| Kim, T | 1 |
| Benedetto, R | 1 |
| Wang, Z | 2 |
| Yao, N | 1 |
| Fu, X | 1 |
| Wei, L | 1 |
| Ding, M | 1 |
| Pang, Y | 1 |
| Liu, D | 1 |
| Ren, Y | 1 |
| Guo, M | 1 |
| Aviello, G | 1 |
| Singh, AK | 1 |
| O'Neill, S | 1 |
| Conroy, E | 1 |
| Gallagher, W | 1 |
| D'Agostino, G | 1 |
| Walker, AW | 1 |
| Bourke, B | 1 |
| Scholz, D | 1 |
| Knaus, UG | 1 |
| Qian, Q | 1 |
| Shi, L | 1 |
| Gao, X | 2 |
| Ma, Y | 2 |
| Yang, J | 3 |
| Qian, J | 1 |
| Koumangoye, R | 1 |
| Omer, S | 1 |
| Kabeer, MH | 1 |
| Delpire, E | 1 |
| Koch, S | 1 |
| Knipfer, L | 1 |
| Kölle, J | 1 |
| Mirzakhani, H | 1 |
| Graser, A | 1 |
| Zimmermann, T | 1 |
| Kiefer, A | 1 |
| Melichar, VO | 1 |
| Rascher, W | 1 |
| Papadopoulos, NG | 1 |
| Rieker, RJ | 1 |
| Raby, BA | 1 |
| Weiss, ST | 1 |
| Wirtz, S | 1 |
| Finotto, S | 1 |
| Garić, D | 1 |
| De Sanctis, JB | 1 |
| Dumut, DC | 1 |
| Shah, J | 1 |
| Peña, MJ | 1 |
| Youssef, M | 1 |
| Petrof, BJ | 1 |
| Kopriva, F | 1 |
| Hanrahan, JW | 1 |
| Hajduch, M | 1 |
| Radzioch, D | 1 |
| Balázs, A | 1 |
| Mall, MA | 8 |
| Liu, W | 1 |
| Mao, B | 1 |
| Jiang, H | 2 |
| Yang, T | 2 |
| Zeng, Z | 1 |
| Shen, Y | 3 |
| Wan, C | 1 |
| Wu, Y | 4 |
| Dong, J | 2 |
| Wen, F | 3 |
| Xue, X | 1 |
| Gao, C | 1 |
| Wang, T | 3 |
| Li, L | 2 |
| Tong, X | 1 |
| Xu, J | 3 |
| Jiang, X | 2 |
| Liu, K | 2 |
| Yang, C | 1 |
| Pieper, M | 1 |
| Schulz-Hildebrandt, H | 1 |
| Hüttmann, G | 1 |
| König, P | 1 |
| Schroeder, HA | 1 |
| Newby, J | 1 |
| Schaefer, A | 1 |
| Subramani, B | 1 |
| Tubbs, A | 1 |
| Gregory Forest, M | 1 |
| Miao, E | 1 |
| Lai, SK | 2 |
| Liao, YSJ | 1 |
| Kuan, SP | 1 |
| Guevara, MV | 1 |
| Collins, EN | 1 |
| Atanasova, KR | 1 |
| Dadural, JS | 1 |
| Vogt, K | 1 |
| Schurmann, V | 1 |
| Bravo, L | 1 |
| Eken, E | 1 |
| Sponchiado, M | 1 |
| Reznikov, LR | 1 |
| Cavalcanti, RFP | 1 |
| Gadelha, FAAF | 1 |
| de Jesus, TG | 1 |
| Cavalcante-Silva, LHA | 1 |
| Paiva Ferreira, LKD | 1 |
| Paiva Ferreira, LAM | 1 |
| Vieira, GC | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Immunostimulation With Polyvalent Mechanical Bacterial Lysate on Changes in the Concentration of iNKT Cells in Children With Allergic Rhinitis.[NCT04802616] | Phase 3 | 80 participants (Actual) | Interventional | 2021-03-22 | Completed | ||
| The Effect Of Polivalent Mechanical Bacterial Lysate On The Clinical Course Of Grass Pollen-Induced Allergic Rhinitis In Children[NCT04270552] | Phase 3 | 76 participants (Actual) | Interventional | 2018-04-22 | Completed | ||
| The Effect of Polyvalent Mechanical Bacterial Lysate on the Reduction of Nasal Staphylococcus Aureus Carriage in Children With Pollen Allergic Rhinitis[NCT04637425] | Phase 3 | 70 participants (Actual) | Interventional | 2018-04-22 | Completed | ||
| Identifying the Role of Pulses in a Healthful Diet: Metabolomic Signatures of Dietary Pulses and Their Benefits on Cardiometabolic Risk Factors[NCT04887584] | 20 participants (Actual) | Interventional | 2022-05-01 | Completed | |||
| Alteration of Intestinal Microflora and Efficacy and Safety of Fecal Microbiota Transplantation for Severe Acute Pancreatitis[NCT03015467] | Phase 1/Phase 2 | 80 participants (Anticipated) | Interventional | 2016-12-31 | Recruiting | ||
| Symptom Based Performance of Airway Clearance Therapy After Starting Highly Effective CFTR Modulator Therapy for Cystic Fibrosis[NCT05392855] | 30 participants (Anticipated) | Interventional | 2023-09-05 | Recruiting | |||
| Assessing Target Engagement of Terazosin in Healthy Adults[NCT04551040] | Phase 1 | 18 participants (Anticipated) | Interventional | 2021-03-26 | Active, not recruiting | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| Phase Ib/II Clinical Trial of Topical Verapamil Hydrochloride for Chronic Rhinosinusitis With Nasal Polyps[NCT03102190] | Phase 1 | 6 participants (Actual) | Interventional | 2017-06-05 | Terminated (stopped due to Phase II funding not available) | ||
| Randomized Double Blind Placebo Controlled Trial of Verapamil in Chronic Rhinosinusitis[NCT02454608] | 29 participants (Actual) | Interventional | 2015-05-31 | Terminated (stopped due to Evidence that the dose is insufficient.) | |||
| A Phase 2 Study of the Safety and Efficacy of BIO-11006 in the Treatment of Recurrent Osteosarcoma and Ewing's Sarcoma in Patients With Lung Metastases[NCT04183062] | Phase 2 | 10 participants (Anticipated) | Interventional | 2019-10-04 | Active, not recruiting | ||
| Comparison of Airway Remodeling Mediators Following Experimental Human Rhinovirus Infection in Subjects With Mild to Moderate Asthma and Healthy, Non-asthmatic Control Subjects[NCT05775952] | 24 participants (Anticipated) | Observational | 2011-09-01 | Recruiting | |||
| Efficacy of Nebulised 5% Hypertonic Saline in Children With Chronic Suppurative Lung Disease[NCT04765033] | Phase 4 | 46 participants (Actual) | Interventional | 2021-02-04 | Completed | ||
| Effect of Exposure to Allergens and Air Pollution on Lung Function and Immunity[NCT01792232] | 18 participants (Actual) | Interventional | 2011-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Dose Limiting Toxicity will be defined as a development of 2nd or 3rd degree heart block as measured by an EKG. (Phase Ib primary outcome) (NCT03102190)
Timeframe: 1-8 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Phase Ib | 0 |
(NCT02454608)
Timeframe: Mean change between baseline and week 8 measurements
| Intervention | mmHg (Mean) |
|---|---|
| Treatment | -0.6 |
| Control | 1 |
(NCT02454608)
Timeframe: Mean change between baseline and week 8 measurements.
| Intervention | beats per minute (Mean) |
|---|---|
| Treatment | -1.4 |
| Control | 4 |
Minimum Score: 0 Maximum Score: 12 Higher value represents worse outcome. (NCT02454608)
Timeframe: baseline to week 8
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Treatment | -1.3 |
| Control | -0.25 |
Minimum Score: 0 Maximum Score: 24 Higher value represents worse outcome. (NCT02454608)
Timeframe: Week 8
| Intervention | units on a scale (Mean) |
|---|---|
| Treatment | 12.5 |
| Control | 17.7 |
Minimum Score: 0 Maximum Score: 100 A higher score indicates a worse outcome. (NCT02454608)
Timeframe: baseline to week 8
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Treatment | -44.03 |
| Control | -6.07 |
Minimum Score: 0 Maximum Score: 110 A higher score indicates a worse outcome (NCT02454608)
Timeframe: baseline to week 8
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Treatment | -27.3 |
| Control | 0.4 |
(NCT02454608)
Timeframe: Mean change between baseline and week 8 measurements
| Intervention | mmHg (Mean) |
|---|---|
| Treatment | -4.5 |
| Control | -6.6 |
Minimum Score: 0 Maximum Score: 100 A higher score indicates a worse outcome. (NCT02454608)
Timeframe: baseline to week 56
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| Medicine Completers, baseline | Medicine Completers, week 56 | Surgical Completers, baseline | Surgical Completers, week 12 | |
| Open Label | 64.3 | 35.0 | 90.0 | 16.7 |
Minimum Score: 0 Maximum Score: 110 A higher score indicates a worse outcome (NCT02454608)
Timeframe: baseline to week 56
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| Medicine Completers, baseline | Medicine Completers, week 56 | Surgical Completers, baseline | Surgical Completers, week 12 | |
| Open Label | 31.8 | 24.14 | 72.00 | 8.00 |
23 reviews available for guaifenesin and Disease Models, Animal
| Article | Year |
|---|---|
Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL-1 signaling pathway.
Topics: Airway Obstruction; Animals; Child; Child, Preschool; Cystic Fibrosis; Disease Models, Animal; Human | 2019 |
Mucociliary Transport in Healthy and Cystic Fibrosis Pig Airways.
Topics: Animals; Animals, Newborn; Cystic Fibrosis; Disease Models, Animal; Mucociliary Clearance; Mucus; Re | 2018 |
Adverse immunological imprinting by cytomegalovirus sensitizing for allergic airway disease.
Topics: Animals; Asthma; Cell Differentiation; Cytokines; Cytomegalovirus Infections; Dendritic Cells; Disea | 2019 |
Mucus and the goblet cell.
Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Goblet Cells; Humans; Mucins; Mucus | 2013 |
Vocal fold epithelial barrier in health and injury: a research review.
Topics: Air Pollutants; Animals; Aquaporins; Cell Membrane; Disease Models, Animal; Humans; Intercellular Ju | 2014 |
Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models.
Topics: Animals; Cilia; Disease Models, Animal; Mice; Mucociliary Clearance; Mucus; Respiratory Mechanics; R | 2008 |
A view on imaging in drug research and development for respiratory diseases.
Topics: Animals; Clinical Trials as Topic; Diagnostic Imaging; Disease Models, Animal; Drug Delivery Systems | 2011 |
CFTR, mucins, and mucus obstruction in cystic fibrosis.
Topics: Airway Obstruction; Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; D | 2012 |
Regulation of mucin genes in chronic inflammatory airway diseases.
Topics: Animals; Asthma; Cystic Fibrosis; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hum | 2006 |
The roles of mucus-associated bacteria in inflammatory bowel disease.
Topics: Adult; Animals; Disease Models, Animal; Helicobacter; Humans; Inflammatory Bowel Diseases; Mucus | 2006 |
Cystic fibrosis and other respiratory diseases of impaired mucus clearance.
Topics: Animals; Cilia; Cystic Fibrosis; Disease Models, Animal; Female; Gene Silencing; Humans; Male; Mice; | 2007 |
Respiratory syncytial virus-induced pulmonary disease and exacerbation of allergic asthma.
Topics: Animals; Asthma; Chemokines; Dendritic Cells; Disease Models, Animal; Humans; Immunity, Innate; Mice | 2007 |
Experimental models of asthma.
Topics: Airway Resistance; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Cilia; Disease Models, Ani | 1982 |
Experimental studies on the pathophysiology of peptic ulcer disease.
Topics: Animals; Disease Models, Animal; Gastric Acid; Gastric Mucosa; Humans; Mucus; Peptic Ulcer; Stomach | 1982 |
Clinical aspects of respiratory mucus.
Topics: Animals; Bronchi; Bronchitis; Calcium; Cilia; Colchicine; Cytochalasin B; Disease Models, Animal; Hu | 1982 |
[Mechanisms of bronchial hyperreactivity. Role of the epithelium].
Topics: Animals; Antigens, CD; Asthma; Biopsy; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capi | 1994 |
Experimental models for studying mucociliary clearance.
Topics: Animals; Cough; Disease Models, Animal; Elasticity; Humans; Models, Biological; Mucociliary Clearanc | 1998 |
Virulence Enhancement Agents for Haemophilus influenzae type B infection in mice.
Topics: Animals; Dextrans; Disease Models, Animal; Haemophilus Infections; Haemophilus influenzae type b; He | 1999 |
Remodeling of the airway epithelium in asthma.
Topics: Animals; Asthma; Biopsy; Bronchi; Bronchoconstriction; Capillary Permeability; Cell Degranulation; C | 2001 |
Secretory cells.
Topics: Animals; Bronchi; Disease Models, Animal; Epithelium; Glycoproteins; Humans; Mice; Mucus; Nicotiana; | 1977 |
The cell biology of mucus secretion in the lung.
Topics: Animals; Disease Models, Animal; Epithelial Cells; Glycoproteins; Humans; Lung; Lung Diseases; Mucus | 1978 |
[Morphological and molecular biological aspects of the origin of experimental stomach cancer].
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Epithelium; Gastric M | 1985 |
Biological effects of cigarette smoking in the pathogenesis of pulmonary disease.
Topics: Animals; Bacteriolysis; Bronchi; Cell Movement; Cilia; Disease Models, Animal; Environmental Exposur | 1973 |
375 other studies available for guaifenesin and Disease Models, Animal
| Article | Year |
|---|---|
Antitussive and expectorant activities of licorice and its major compounds.
Topics: Administration, Oral; Ammonia; Animals; Antitussive Agents; Cough; Disease Models, Animal; Dose-Resp | 2018 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
High throughput virtual screening strategy to develop a potential treatment for bronchial asthma by targeting interleukin 13 cytokine signaling.
Topics: Animals; Asthma; Child; Cytokines; Disease Models, Animal; Epinephrine; Guaifenesin; Humans; Hyperse | 2022 |
Titanium Dioxide Nanoparticles Exacerbate Allergic Airway Inflammation via TXNIP Upregulation in a Mouse Model of Asthma.
Topics: Animals; Apoptosis; Asthma; bcl-2-Associated X Protein; Bronchoalveolar Lavage Fluid; Carrier Protei | 2021 |
ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells.
Topics: Animals; Disease Models, Animal; Epithelial Cells; Humans; Integrin beta4; Mice; Mucin 5AC; Mucus; R | 2022 |
Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs.
Topics: Acinar Cells; Animals; Biomarkers; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regula | 2022 |
CTNNAL1 participates in the regulation of mucus overproduction in HDM-induced asthma mouse model through the YAP-ROCK2 pathway.
Topics: alpha Catenin; Animals; Asthma; Disease Models, Animal; Humans; Interleukin-13; Interleukin-4; Lung; | 2022 |
Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease.
Topics: Animals; Asthma; Cells, Cultured; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Ca | 2022 |
Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Humans; Inflammation; Mice; Mucin 5AC; Muci | 2022 |
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Docosahexaeno | 2022 |
Azithromycin inhibits mucin secretion, mucous metaplasia, airway inflammation, and airways hyperresponsiveness in mice exposed to house dust mite extract.
Topics: Adenosine Triphosphate; Allergens; Animals; Asthma; Azithromycin; Disease Models, Animal; Inflammati | 2022 |
Iristectorigenin A exerts novel protective properties against airway inflammation and mucus hypersecretion in OVA-induced asthmatic mice: Iristectorigenin A ameliorates asthma phenotype.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Immunoglobulin E; Immunoglobu | 2022 |
Milk Fat Globule Membrane Attenuates Acute Colitis and Secondary Liver Injury by Improving the Mucus Barrier and Regulating the Gut Microbiota.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Glycolipids; | 2022 |
Selective Pharmaceutical Inhibition of PARP14 Mitigates Allergen-Induced IgE and Mucus Overproduction in a Mouse Model of Pulmonary Allergic Response.
Topics: Allergens; Animals; Asthma; Disease Models, Animal; Immunoglobulin E; Mice; Mucus; Pharmaceutical Pr | 2022 |
Oxysophocarpine inhibits airway inflammation and mucus hypersecretion through JNK/AP-1 pathway in vivo and in vitro.
Topics: Alkaloids; Animals; Antioxidants; Asthma; Cytokines; Disease Models, Animal; Eosine Yellowish-(YS); | 2022 |
Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice.
Topics: Animals; Arsenic; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Drinking | 2022 |
Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis.
Topics: Adenosine; Animals; Disease Models, Animal; Inflammation; Mice; Mucins; Mucus; Sinusitis | 2023 |
Modified Gegen Qinlian decoction ameliorates DSS-induced chronic colitis in mice by restoring the intestinal mucus barrier and inhibiting the activation of γδT17 cells.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Inflammasomes | 2023 |
Shaoyao decoction restores the mucus layer in mice with DSS-induced colitis by regulating Notch signaling pathway.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Drugs, Chines | 2023 |
Rosmarinic Acid Restores Colonic Mucus Secretion in Colitis Mice by Regulating Gut Microbiota-Derived Metabolites and the Activation of Inflammasomes.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Inflammasome | 2023 |
LncRNA EPR regulates intestinal mucus production and protects against inflammation and tumorigenesis.
Topics: Animals; Cell Transformation, Neoplastic; Colon; Disease Models, Animal; Humans; Inflammation; Intes | 2023 |
Altered Secretion, Constitution, and Functional Properties of the Gastrointestinal Mucus in a Rat Model of Sporadic Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Goblet Cells; Mucins; Mucus; Rats | 2023 |
Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Humans; Hypersensitivity; Inf | 2023 |
Qufeng Xuanbi Formula inhibited benzo[a]pyrene-induced aggravated asthma airway mucus secretion by AhR/ROS/ERK pathway.
Topics: Air Pollutants; Animals; Asthma; Benzo(a)pyrene; Disease Models, Animal; Extracellular Signal-Regula | 2024 |
Melia azedarach L. reduces pulmonary inflammation and mucus hypersecretion on a murine model of ovalbumin exposed asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Inflammation; Meli | 2024 |
Niclosamide repurposed for the treatment of inflammatory airway disease.
Topics: Animals; Anoctamins; Anti-Inflammatory Agents; Asthma; Bronchi; Cell Line, Tumor; Cystic Fibrosis; D | 2019 |
Butylphthalide ameliorates airway inflammation and mucus hypersecretion via NF-κB in a murine asthma model.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Benzofurans; Bronchoalv | 2019 |
Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects.
Topics: Animals; Anti-Bacterial Agents; Colitis; Colon; Cytochrome b Group; Disease Models, Animal; Dysbiosi | 2019 |
A Paclitaxel-Based Mucoadhesive Nanogel with Multivalent Interactions for Cervical Cancer Therapy.
Topics: Acrylic Resins; Adhesiveness; Animals; beta-Cyclodextrins; Cell Death; Cell Line, Tumor; Cell Membra | 2019 |
Novel Human NKCC1 Mutations Cause Defects in Goblet Cell Mucus Secretion and Chronic Inflammation.
Topics: Animals; Chronic Disease; Citrobacter rodentium; Colectomy; Colitis; Colon; Disease Models, Animal; | 2020 |
Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2).
Topics: Animals; Asthma; Carrier Proteins; Child; Child, Preschool; Disease Models, Animal; Female; Humans; | 2019 |
Fenretinide favorably affects mucins (MUC5AC/MUC5B) and fatty acid imbalance in a manner mimicking CFTR-induced correction.
Topics: Administration, Oral; Animals; Arachidonic Acid; Cell Line; Cystic Fibrosis; Disease Models, Animal; | 2020 |
Systems pharmacology-based study of Tanreqing injection in airway mucus hypersecretion.
Topics: Animals; Data Analysis; Disease Models, Animal; Drugs, Chinese Herbal; Ethnopharmacology; Humans; Li | 2020 |
Serotonin receptors 5-HTR2A and 5-HTR2B are involved in cigarette smoke-induced airway inflammation, mucus hypersecretion and airway remodeling in mice.
Topics: Airway Remodeling; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Humans; Injections | 2020 |
Rhubarb-Evoke Mucus Secretion through Aggregation and Degranulation of Mast Cell in the Colon of Rat: In vivo and ex vivo studies.
Topics: Animals; Cell Aggregation; Cell Degranulation; Colon; Cytokines; Digestive System; Disease Models, A | 2019 |
Iloprost inhibits acute allergic nasal inflammation by GATA3 -ILC2 pathway in mice.
Topics: Animals; Disease Models, Animal; Female; GATA3 Transcription Factor; Goblet Cells; Hyperplasia; Ilop | 2020 |
Intravital microscopic optical coherence tomography imaging to assess mucus-mobilizing interventions for muco-obstructive lung disease in mice.
Topics: Animals; Disease Models, Animal; Epithelial Sodium Channels; Humans; Intravital Microscopy; Lung Dis | 2020 |
LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus.
Topics: Animals; Antibodies, Bacterial; Disease Models, Animal; Immunoglobulin Fab Fragments; Immunoglobulin | 2020 |
Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Airway Obstruction; Anima | 2020 |
Warifteine and methylwarifteine inhibited the type 2 immune response on combined allergic rhinitis and asthma syndrome (CARAS) experimental model through NF-кB pathway.
Topics: Alkaloids; Animals; Anti-Allergic Agents; Asthma; Behavior, Animal; Bronchoalveolar Lavage Fluid; Ci | 2020 |
Panax notoginseng saponin R1 modulates TNF-α/NF-κB signaling and attenuates allergic airway inflammation in asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Disease Models, Ani | 2020 |
Ursolic Acid Alleviates Mucus Secretion and Tissue Remodeling in Rat Model of Allergic Rhinitis After PM2.5 Exposure.
Topics: Animals; Disease Models, Animal; Mucus; Nasal Mucosa; Ovalbumin; Particulate Matter; Rats; Rhinitis, | 2021 |
The establishment of humanized IL-4/IL-4RA mouse model by gene editing and efficacy evaluation.
Topics: Allergens; Animals; Antibodies, Monoclonal; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; D | 2020 |
Symbiotic microbiome Staphylococcus aureus from human nasal mucus modulates IL-33-mediated type 2 immune responses in allergic nasal mucosa.
Topics: Animals; Corynebacterium; Cytokines; Disease Models, Animal; Enterobacter aerogenes; Epithelial Cell | 2020 |
Pulmonary Mycosis Drives Forkhead Box Protein A2 Degradation and Mucus Hypersecretion through Activation of the Spleen Tyrosine Kinase-Epidermal Growth Factor Receptor-AKT/Extracellular Signal-Regulated Kinase 1/2 Signaling.
Topics: Animals; Blastomycosis; Cats; Disease Models, Animal; Dogs; ErbB Receptors; Hepatocyte Nuclear Facto | 2021 |
Copaifera malmei Harms leaves infusion attenuates TNBS-ulcerative colitis through modulation of cytokines, oxidative stress and mucus in experimental rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Colitis, Ulcerative; Colon; Cytokines; | 2021 |
Mitoquinone ameliorates cigarette smoke-induced airway inflammation and mucus hypersecretion in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Disease Models, Animal; Inflammation Med | 2021 |
TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model.
Topics: Acupuncture Therapy; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Anima | 2021 |
Dilodendron bipinnatum Radlk. extract alleviates ulcerative colitis induced by TNBS in rats by reducing inflammatory cell infiltration, TNF-α and IL-1β concentrations, IL-17 and COX-2 expressions, supporting mucus production and promotes an antioxidant ef
Topics: Animals; Antioxidants; Brazil; Caco-2 Cells; Cell Survival; Colitis, Ulcerative; Cyclooxygenase 2; D | 2021 |
Disulfide disruption reverses mucus dysfunction in allergic airway disease.
Topics: Adolescent; Adult; Animals; Asthma; Disease Models, Animal; Disulfides; Expectorants; Female; Glycop | 2021 |
Long non-coding RNA TUG1 promotes airway remodeling and mucus production in asthmatic mice through the microRNA-181b/HMGB1 axis.
Topics: Airway Remodeling; Allergens; Animals; Asthma; Cells, Cultured; Disease Models, Animal; Female; HMGB | 2021 |
Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma.
Topics: Animals; Asthma; Disease Models, Animal; Mice; Mucus; Polyporaceae; Th2 Cells | 2021 |
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult
Topics: Animals; Cathepsins; Cystic Fibrosis; Disease Models, Animal; Epithelial Sodium Channels; Inflammati | 2021 |
Mainstream Cigarette Smoke Impacts the Mouse Vocal Fold Epithelium and Mucus Barrier.
Topics: Adult; Animals; Cigarette Smoking; Disease Models, Animal; Epithelium; Female; Humans; Laryngeal Muc | 2021 |
Tectochrysin ameliorates murine allergic airway inflammation by suppressing Th2 response and oxidative stress.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Basophil | 2021 |
VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway.
Topics: Airway Obstruction; Animals; Cell Transdifferentiation; Disease Models, Animal; Gene Expression Regu | 2021 |
sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Glyco | 2022 |
Casein-fed mice showed faster recovery from DSS-induced colitis than chicken-protein-fed mice.
Topics: Animals; Bacteria; Body Weight; Caseins; Chickens; Colitis; Colon; Dextran Sulfate; Disease Models, | 2021 |
Epithelium-derived IL17A Promotes Cigarette Smoke-induced Inflammation and Mucus Hyperproduction.
Topics: Animals; Cell Line; Cigarette Smoking; Disease Models, Animal; Humans; Inflammation; Interleukin-17; | 2021 |
Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease.
Topics: Amino Acid Sequence; Animals; Biomarkers; Disease Models, Animal; Disease Susceptibility; Endoplasmi | 2021 |
Postnatal Ozone Exposure Disrupts Alveolar Development, Exaggerates Mucoinflammatory Responses, and Suppresses Bacterial Clearance in Developing
Topics: Animals; Bacteria; Cystic Fibrosis; Disease Models, Animal; Epithelial Sodium Channels; Inflammation | 2021 |
IRE1β does not affect mucus secretion during allergic asthma development in a house dust mite murine model.
Topics: Allergens; Animals; Asthma; Disease Models, Animal; Humans; Mice; Mucus; Pyroglyphidae | 2021 |
Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus.
Topics: Adult; Aged; Animals; Asthma; Chronic Disease; Disease Models, Animal; Eosinophils; Female; Fibrin; | 2017 |
Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients.
Topics: Animals; Asthma; Disease Models, Animal; Epithelial Cells; Humans; Immunity, Innate; Interleukin-13; | 2018 |
Anti‑inflammatory effects of dihydromyricetin in a mouse model of asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, | 2017 |
Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice.
Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flu | 2017 |
BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
Topics: Airway Remodeling; Airway Resistance; Animals; ARNTL Transcription Factors; Asthma; Bronchiolitis, V | 2018 |
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid | 2017 |
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid | 2017 |
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid | 2017 |
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid | 2017 |
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid | 2017 |
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid | 2017 |
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid | 2017 |
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid | 2017 |
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid | 2017 |
Compositional Changes in the Gut Mucus Microbiota Precede the Onset of Colitis-Induced Inflammation.
Topics: Animals; Bacteria; Colitis; Colon; Disease Models, Animal; DNA, Bacterial; Dysbiosis; Feces; Gastroi | 2017 |
Isoimperatorin attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma.
Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Cytokines; Disease Models, Animal; Female; Fur | 2017 |
Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease.
Topics: Animals; Animals, Newborn; Bacterial Infections; Bacterial Load; Cell Movement; Cystic Fibrosis; Dis | 2017 |
Therapeutic intranasal instillation of allergen-loaded microbubbles suppresses experimental allergic asthma in mice.
Topics: Adjuvants, Immunologic; Administration, Intranasal; Allergens; Animals; Antibody Formation; Asthma; | 2017 |
Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma.
Topics: Animals; Arginase; Asthma; Bronchoalveolar Lavage Fluid; Cell Differentiation; Disease Models, Anima | 2017 |
Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Bronchoalveolar Lavage Fluid; Cytokines; Disea | 2017 |
Capsule Type and Amount Affect Shedding and Transmission of
Topics: Animals; Animals, Newborn; Bacterial Capsules; Bacterial Shedding; Disease Models, Animal; Host-Path | 2017 |
Limax extract ameliorates cigarette smoke-induced chronic obstructive pulmonary disease in mice.
Topics: Animals; Cigarette Smoking; Complex Mixtures; Cytokines; Disease Models, Animal; Gastropoda; Humans; | 2018 |
Progression of Type 2 Helper T Cell-Type Inflammation and Airway Remodeling in a Rodent Model of Naturally Acquired Subclinical Primary Pneumocystis Infection.
Topics: Animals; Bronchioles; Disease Models, Animal; Disease Progression; Extracellular Matrix; Female; Gen | 2018 |
Phloretin attenuates mucus hypersecretion and airway inflammation induced by cigarette smoke.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cigarette Smoking; Disease Models, Animal; ErbB Recept | 2018 |
Development of an airway mucus defect in the cystic fibrosis rat.
Topics: Animals; Bicarbonates; Biological Transport; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conducta | 2018 |
Endoplasmic reticulum chaperone GRP78 mediates cigarette smoke-induced necroptosis and injury in bronchial epithelium.
Topics: Animals; Apoptosis; Bronchi; Cell Line; Cytokines; Disease Models, Animal; Endoplasmic Reticulum Cha | 2018 |
Effects of ozone repeated short exposures on the airway/lung inflammation, airway hyperresponsiveness and mucus production in a mouse model of ovalbumin-induced asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Enzyme-Linked Immunosorbent Assa | 2018 |
Bacillus subtilis spore with surface display of paramyosin from Clonorchis sinensis potentializes a promising oral vaccine candidate.
Topics: Administration, Oral; Animals; Antibodies, Helminth; Bacillus subtilis; Bile; Blood Chemical Analysi | 2018 |
LPS Exposure in Early Life Protects Against Mucus Hypersecretion in Ovalbumin-Induced Asthma by Down-Regulation of the IL-13 and JAK-STAT6 Pathways.
Topics: Administration, Intranasal; Animals; Asthma; Cell Line; Disease Models, Animal; Down-Regulation; Hum | 2018 |
In vivo and in vitro investigation of anti-inflammatory and mucus-regulatory activities of a fixed combination of thyme and primula extracts.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Epithelial Cells; Humans; Lipo | 2018 |
The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation.
Topics: Animals; Cholinergic Agents; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; D | 2018 |
Peroxisome proliferator-activated receptor gamma activation promotes intestinal barrier function by improving mucus and tight junctions in a mouse colitis model.
Topics: Animals; Caco-2 Cells; Colitis; Dextran Sulfate; Disease Models, Animal; HT29 Cells; Humans; Intesti | 2018 |
TRPC1 intensifies house dust mite-induced airway remodeling by facilitating epithelial-to-mesenchymal transition and STAT3/NF-κB signaling.
Topics: Airway Remodeling; Animals; Bronchi; Calcium; Collagen; Disease Models, Animal; Down-Regulation; Epi | 2019 |
Antisense oligonucleotide targeting of mRNAs encoding ENaC subunits α, β, and γ improves cystic fibrosis-like disease in mice.
Topics: Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Anima | 2019 |
An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Topics: Airway Remodeling; Airway Resistance; Animals; Asthma; Bronchi; Cell Count; Disease Models, Animal; | 2018 |
Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs.
Topics: Animals; Bacteria; Bronchoalveolar Lavage Fluid; Cystic Fibrosis; Disease Models, Animal; Epithelial | 2018 |
An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases.
Topics: Acetylcysteine; Animals; Asthma; Cystic Fibrosis; Disease Models, Animal; Dithiothreitol; Expectoran | 2019 |
FOXA2 depletion leads to mucus hypersecretion in canine airways with respiratory diseases.
Topics: Animals; Bordetella Infections; Bronchitis; Disease Models, Animal; Dogs; Goblet Cells; Hepatocyte N | 2019 |
Fra2 Overexpression in Mice Leads to Non-allergic Asthma Development in an IL-13 Dependent Manner.
Topics: Animals; Antibodies, Blocking; Asthma; Cell Proliferation; Cells, Cultured; Cytokines; Disease Model | 2018 |
Akkermansia muciniphila strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice.
Topics: Animals; Body Weight; Cecum; Disease Models, Animal; Escherichia coli; Gastrointestinal Microbiome; | 2019 |
Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chemokines; Dis | 2018 |
Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis.
Topics: Animals; Animals, Outbred Strains; Citrobacter rodentium; Colitis; Colon; Dibenzazepines; Disease Mo | 2018 |
Pulmonary Neuroendocrine Cells Secrete γ-Aminobutyric Acid to Induce Goblet Cell Hyperplasia in Primate Models.
Topics: Acute Lung Injury; Animals; Asthma; Bronchi; Disease Models, Animal; Epithelial Cells; gamma-Aminobu | 2019 |
S-Allyl cysteine reduces eosinophilic airway inflammation and mucus overproduction on ovalbumin-induced allergic asthma model.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage | 2019 |
Targeting of cathepsin S reduces cystic fibrosis-like lung disease.
Topics: Airway Obstruction; Animals; Cathepsins; Cystic Fibrosis; Disease Models, Animal; Epithelial Sodium | 2019 |
Recruitment manoeuvres dislodge mucus towards the distal airways in an experimental model of severe pneumonia.
Topics: Airway Management; Animals; Disease Models, Animal; Female; Intubation, Intratracheal; Mucus; Peak E | 2019 |
A model of clinical endometritis in Holstein heifers using pathogenic Escherichia coli and Trueperella pyogenes.
Topics: Actinomycetaceae; Actinomycetales Infections; Animals; Body Fluids; Cattle; Cattle Diseases; Disease | 2019 |
Physalis peruviana L. inhibits ovalbumin‑induced airway inflammation by attenuating the activation of NF‑κB and inflammatory molecules.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Chemokine CCL2; Disease Models, Animal; Down-Regu | 2019 |
A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus.
Topics: Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Anima | 2019 |
Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Topics: Adaptive Immunity; Adjuvants, Immunologic; Animals; Asthma; Bronchial Hyperreactivity; Crystallizati | 2019 |
Rho-kinase inhibitor attenuates airway mucus hypersecretion and inflammation partly by downregulation of IL-13 and the JNK1/2-AP1 signaling pathway.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Down-Regulation; Female; Infl | 2019 |
Food Polyelectrolytes Compress the Colonic Mucus Hydrogel by a Donnan Mechanism.
Topics: Animals; Bacterial Infections; Biofilms; Carboxymethylcellulose Sodium; Colon; Disease Models, Anima | 2019 |
ORMDL3 knockdown in the lungs alleviates airway inflammation and airway remodeling in asthmatic mice via JNK1/2-MMP-9 pathway.
Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Child; Disease Models, Animal; Fem | 2019 |
Anti-inflammatory activity of SintMed65, an N-acylhydrazone derivative, in a mouse model of allergic airway inflammation.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage | 2019 |
Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial
Topics: Acids; Animals; Autophagy; Bacterial Proteins; Dextran Sulfate; Dinoprostone; Disease Models, Animal | 2019 |
Dendritic polyglycerolsulfate near infrared fluorescent (NIRF) dye conjugate for non-invasively monitoring of inflammation in an allergic asthma mouse model.
Topics: Animals; Asthma; Disease Models, Animal; Female; Fluorescent Dyes; Glycerol; Immunoglobulin G; Infla | 2013 |
Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice.
Topics: Airway Remodeling; Aldehyde Reductase; Animals; Asthma; Biomarkers; Chronic Disease; Disease Models, | 2013 |
Pinellia ternata Breitenbach attenuates ovalbumin-induced allergic airway inflammation and mucus secretion in a murine model of asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease | 2013 |
Hypertonic saline is effective in the prevention and treatment of mucus obstruction, but not airway inflammation, in mice with chronic obstructive lung disease.
Topics: Age Factors; Animals; Animals, Newborn; Chemotaxis; Disease Models, Animal; Epithelial Sodium Channe | 2013 |
Dihydroartemisinin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model.
Topics: Animals; Anti-Asthmatic Agents; Artemisinins; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disea | 2013 |
Beneficial role of the probiotic mixture Ultrabiotique on maintaining the integrity of intestinal mucosal barrier in DSS-induced experimental colitis.
Topics: Animals; Bifidobacterium; Colitis, Ulcerative; Dextran Sulfate; Dietary Supplements; Disease Models, | 2013 |
Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent.
Topics: Acetates; Animals; Bacteroides; Bacteroides Infections; Cell Differentiation; Colon; Disease Models, | 2013 |
Divergent immune responses to Mycobacterium avium subsp. paratuberculosis infection correlate with kinome responses at the site of intestinal infection.
Topics: Animals; Cattle; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Host-Pathogen Interact | 2013 |
A respiratory syncytial virus (RSV) anti-G protein F(ab')2 monoclonal antibody suppresses mucous production and breathing effort in RSV rA2-line19F-infected BALB/c mice.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Viral; Chemoprevention; Disease Models, Animal; Female; | 2013 |
Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.
Topics: Animals; Animals, Newborn; Antibodies, Neutralizing; Apoptosis; Chlamydia Infections; Chlamydia muri | 2014 |
Tiotropium bromide inhibits relapsing allergic asthma in BALB/c mice.
Topics: Airway Remodeling; Animals; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Dexamethasone; | 2014 |
Effects of montelukast on subepithelial/peribronchial fibrosis in a murine model of ovalbumin induced chronic asthma.
Topics: Acetates; Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cycloprop | 2013 |
Mast cell-deficient kit mice develop house dust mite-induced lung inflammation despite impaired eosinophil recruitment.
Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Chemokine CCL11; Disease Models, Animal; E | 2014 |
Early-life exposure to combustion-derived particulate matter causes pulmonary immunosuppression.
Topics: Adoptive Transfer; Allergens; Animals; Animals, Newborn; Antigens; Asthma; Dendritic Cells; Disease | 2014 |
REG3γ-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum.
Topics: Animals; Disease Models, Animal; Gene Expression Profiling; Ileum; Immunity, Innate; Inflammation; I | 2014 |
γδ T-cell-deficient mice show alterations in mucin expression, glycosylation, and goblet cells but maintain an intact mucus layer.
Topics: Animals; Antigens, Surface; Colitis; Dextran Sulfate; Disease Models, Animal; Epidermal Growth Facto | 2014 |
Naringenin inhibits allergen‑induced airway remodeling in a murine model of asthma.
Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flu | 2014 |
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease.
Topics: Airway Obstruction; Animals; Bronchiectasis; Cystic Fibrosis; Disease Models, Animal; Epithelial Sod | 2014 |
Impact of a Met(11)Thr single nucleotide polymorphism of surfactant protein D on allergic airway inflammation in a murine asthma model.
Topics: Animals; Disease Models, Animal; Humans; Lung; Male; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; | 2014 |
Treatment with the C5a receptor/CD88 antagonist PMX205 reduces inflammation in a murine model of allergic asthma.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, | 2014 |
The intestinal mucus layer is a critical component of the gut barrier that is damaged during acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Antioxidants; Disease Models, Animal; Disease Progression; Ileum; | 2014 |
Siegesbeckia glabrescens attenuates allergic airway inflammation in LPS-stimulated RAW 264.7 cells and OVA induced asthma murine model.
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Cel | 2014 |
Pdcd4 modulates markers of macrophage alternative activation and airway remodeling in antigen-induced pulmonary inflammation.
Topics: Airway Remodeling; Animals; Apoptosis Regulatory Proteins; Arginase; Asthma; beta-N-Acetylhexosamini | 2014 |
Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis.
Topics: Animals; Animals, Newborn; Anions; Cilia; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance | 2014 |
Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis.
Topics: Animals; Animals, Newborn; Anions; Cilia; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance | 2014 |
Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis.
Topics: Animals; Animals, Newborn; Anions; Cilia; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance | 2014 |
Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis.
Topics: Animals; Animals, Newborn; Anions; Cilia; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance | 2014 |
Airway remodeling is reversed by aerobic training in a murine model of chronic asthma.
Topics: Airway Remodeling; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Cell Movement; Chemokine | 2015 |
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod | 2014 |
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod | 2014 |
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod | 2014 |
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod | 2014 |
Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling.
Topics: Animals; Antioxidants; Cell Line, Tumor; Disease Models, Animal; Extracellular Signal-Regulated MAP | 2015 |
Healing process in mice model of surgical wounds enhanced by Phyllocaulis boraceiensis mucus.
Topics: Animals; Biological Products; Cell Proliferation; Disease Models, Animal; Female; Gastropoda; Mice; | 2014 |
Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Disease Models, Animal; Eosino | 2015 |
Serotonin 5-HT₂ receptor activation prevents allergic asthma in a mouse model.
Topics: 5-Hydroxytryptophan; Amphetamines; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactiv | 2015 |
Terminalia catappa L.: a medicinal plant from the Caribbean pharmacopeia with anti-Helicobacter pylori and antiulcer action in experimental rodent models.
Topics: Acetic Acid; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Caribbean Region; Disease Models, An | 2015 |
Lipoxin B₄ promotes the resolution of allergic inflammation in the upper and lower airways of mice.
Topics: Animals; Cell Degranulation; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Eosinophils; | 2015 |
Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-κB in a murine model of asthma.
Topics: Airway Remodeling; Animals; Asthma; Blotting, Western; Bronchi; Bronchoalveolar Lavage Fluid; Diseas | 2015 |
Protective effect of δ-amyrone against ethanol-induced gastric ulcer in mice.
Topics: Animals; Cytokines; Disease Models, Animal; Ethanol; Gastric Acidity Determination; Gastric Mucosa; | 2015 |
The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology.
Topics: Activins; Adult; Animals; Body Weight; Cystic Fibrosis; Disease Models, Animal; Female; Follistatin; | 2015 |
The Flavonoid 7,4'-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-κB, STAT6, and HDAC2.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Disease Models, Animal; Epithelial Cells; | 2015 |
The sickle cell mouse lung: proinflammatory and primed for allergic inflammation.
Topics: Anemia, Sickle Cell; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytok | 2015 |
The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation.
Topics: Allergens; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage F | 2015 |
Carvedilol attenuates inflammatory biomarkers and oxidative stress in a rat model of ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbazoles; Carvedilol; Colitis, Ulcera | 2015 |
Exposure to Deepwater Horizon Crude Oil Burnoff Particulate Matter Induces Pulmonary Inflammation and Alters Adaptive Immune Response.
Topics: Adaptive Immunity; Animals; Asthma; Cell Death; Cell Line; Cell Survival; Dinoprost; Disease Models, | 2015 |
Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCRαβ+ Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis.
Topics: Animals; Antimicrobial Cationic Peptides; Colitis; Cytokines; Disease Models, Animal; Intestinal Muc | 2015 |
SP600125 promotes resolution of allergic airway inflammation via TLR9 in an OVA-induced murine acute asthma model.
Topics: Acute Disease; Animals; Anthracenes; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Di | 2015 |
PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.
Topics: Adoptive Transfer; Animals; Antigens, CD; Asthma; Bronchial Hyperreactivity; CD4-Positive T-Lymphocy | 2015 |
Rho-kinase inhibitor fasudil reduces allergic airway inflammation and mucus hypersecretion by regulating STAT6 and NFκB.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Allergens; Animals; Asthma; Case-Control Studies; Cel | 2015 |
[Effects of ozone oxidative stress on the airway hyperresponsiveness and mucus production in mice with acute allergic airway inflammation].
Topics: Animals; Asthma; Bronchoalveolar Lavage; Disease Models, Animal; Female; Inflammation; Interleukin-1 | 2015 |
Callicarpa japonica Thunb. attenuates cigarette smoke-induced neutrophil inflammation and mucus secretion.
Topics: Animals; Bronchoalveolar Lavage Fluid; Callicarpa; Cell Line; Cell Line, Tumor; Disease Models, Anim | 2015 |
Glucagon Like Peptide-1 (GLP-1) Modulates OVA-Induced Airway Inflammation and Mucus Secretion Involving a Protein Kinase A (PKA)-Dependent Nuclear Factor-κB (NF-κB) Signaling Pathway in Mice.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cyclic AMP-Dependent Protein Kinases; Cytokines; Dise | 2015 |
Copper oxide nanoparticles aggravate airway inflammation and mucus production in asthmatic mice via MAPK signaling.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Copper; Cytokines; Disease Models, Animal | 2016 |
Resveratrol inhibits mucus overproduction and MUC5AC expression in a murine model of asthma.
Topics: Animals; Asthma; Cell Line; Disease Models, Animal; Epithelial Cells; Female; Gene Expression Regula | 2016 |
Continuous Exposure to Low-Dose-Rate Gamma Irradiation Reduces Airway Inflammation in Ovalbumin-Induced Asthma.
Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Choline; Disease Models, | 2015 |
On the Pathogenesis of Acute Exacerbations of Mucoobstructive Lung Diseases.
Topics: Animals; Disease Models, Animal; Disease Progression; Humans; Lung; Lung Diseases, Obstructive; Mice | 2015 |
Heat-labile enterotoxin of Escherichia coli promotes intestinal colonization of Salmonella enterica.
Topics: Animals; Bacterial Load; Bacterial Toxins; Cell Line; Cell Survival; Diarrhea; Disease Models, Anima | 2015 |
Gastroprotective effects of thymol on acute and chronic ulcers in rats: The role of prostaglandins, ATP-sensitive K(+) channels, and gastric mucus secretion.
Topics: Acetic Acid; Acute Disease; Animals; Chronic Disease; Disease Models, Animal; Dose-Response Relation | 2016 |
Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation.
Topics: Adoptive Transfer; Animals; Asthma; Disease Models, Animal; Drug Resistance; Immunoblotting; Interle | 2016 |
Suhuang antitussive capsule at lower doses attenuates airway hyperresponsiveness, inflammation, and remodeling in a murine model of chronic asthma.
Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; | 2016 |
Mechanism(s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Dinoprostone; Disease Models, Animal; Gallic Acid; Gastric | 2016 |
Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma.
Topics: Administration, Oral; Animals; Anti-Asthmatic Agents; Asthma; Cytokines; Disease Models, Animal; Dos | 2016 |
Alpha-boswellic acid protects against ethanol-induced gastric injury in rats: involvement of nuclear factor erythroid-2-related factor 2/heme oxygenase-1 pathway.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Biomarkers; Cytoprotection; Dinoprostone; Disease Models, | 2016 |
Recombinant human deoxyribonuclease therapy improves airway resistance and reduces DNA extracellular traps in a murine acute asthma model.
Topics: Administration, Intranasal; Airway Obstruction; Airway Resistance; Allergens; Animals; Asthma; Bronc | 2016 |
Early-Life Intranasal Colonization with Nontypeable Haemophilus influenzae Exacerbates Juvenile Airway Disease in Mice.
Topics: Animals; Bacterial Load; Cytokines; Disease Models, Animal; Disease Progression; Female; Haemophilus | 2016 |
Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice.
Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Colitis, Ulcerative; Colon; Disease Models, Animal; | 2017 |
IL-22 exacerbates weight loss in a murine model of chronic pulmonary Pseudomonas aeruginosa infection.
Topics: Animals; Chronic Disease; Cystic Fibrosis; Disease Models, Animal; Interleukin-22; Interleukins; Lun | 2016 |
[The effect and injury to the airways of different sputum aspiration pressure in a rat model of mucus hypersecretion].
Topics: Animals; Biopsy, Needle; Disease Models, Animal; Interleukin-1beta; Mucus; Pressure; Random Allocati | 2016 |
The involvement of central nervous system histamine receptors in psychological stress-induced exacerbation of allergic airway inflammation in mice.
Topics: Animals; Antigens; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Central Nervous System; | 2016 |
Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity.
Topics: Animals; Antioxidants; Capsaicin; Chromatography, High Pressure Liquid; Chronic Disease; Disease Mod | 2017 |
IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models.
Topics: Allergens; Animals; Asthma; Blood Cells; Cytokines; Dermatophagoides pteronyssinus; Disease Models, | 2017 |
Laryngeal mucus hypersecretion is exacerbated after smoking cessation and ameliorated by glucocorticoid administration.
Topics: Animals; Cytokines; Disease Models, Animal; Glucocorticoids; Laryngeal Mucosa; Laryngitis; Male; Muc | 2017 |
Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma.
Topics: Animals; Asthma; Biomarkers; Case-Control Studies; Cytokines; Disease Models, Animal; Endoplasmic Re | 2017 |
Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats.
Topics: Aluminum Hydroxide; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Disease Models, Animal; Dose- | 2017 |
Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation.
Topics: Animals; Cytokines; Disease Models, Animal; Gene Expression; Humans; Mice; Mice, Knockout; Models, B | 2017 |
Novel triple neurokinin receptor antagonist CS-003 inhibits respiratory disease models in guinea pigs.
Topics: Administration, Oral; Animals; Asthma; Bronchoconstriction; Capillary Permeability; Capsaicin; Cough | 2008 |
Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration.
Topics: Animals; Arginase; Boronic Acids; Bronchi; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enz | 2008 |
Endothelin A receptor antagonist modulates lymphocyte and eosinophil infiltration, hyperreactivity and mucus in murine asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; En | 2008 |
Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchoalveolar Lav | 2009 |
Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma.
Topics: Airway Obstruction; Allergens; Animals; Apoptosis; Asthma; Cell Adhesion; Cytokines; Disease Models, | 2009 |
Gastric antisecretory and antiulcer activities of Cyclea peltata (Lam.) Hook. f. & Thoms. in rats.
Topics: Animals; Anti-Ulcer Agents; Catalase; Cyclea; Disease Models, Animal; Ethanol; Gastric Juice; Gastri | 2009 |
Environmental tobacco smoke exposure does not prevent corticosteroids reducing inflammation, remodeling, and airway hyperreactivity in mice exposed to allergen.
Topics: Adrenal Cortex Hormones; Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Disease Mod | 2009 |
Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice.
Topics: Adenosine; Allergens; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Chronic Disease; Disease Model | 2010 |
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.
Topics: Animals; Asthma; Disease Models, Animal; Epithelial Cells; Gene Expression; Hepatocyte Nuclear Facto | 2009 |
Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus.
Topics: Animals; Cell Line; Cervix Uteri; Disease Models, Animal; Female; HIV Infections; HIV-1; Humans; Hyd | 2009 |
Prostaglandin E2 receptor EP2, EP3, and EP4 agonists inhibit antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats.
Topics: Alprostadil; Animals; Dinoprostone; Disease Models, Animal; Hypertrophy; Male; Metaplasia; Methyl Et | 2009 |
Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chemokine CCL5; Disease Mo | 2010 |
Gastroprotective activity of Trichosanthes cucumerina in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Ethanol; Female; Gastric Juice; Gast | 2010 |
Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice.
Topics: Acetylcysteine; Animals; Anti-Ulcer Agents; Antioxidants; Capsaicin; Disease Models, Animal; Diterpe | 2010 |
The plant extract Isatis tinctoria L. extract (ITE) inhibits allergen-induced airway inflammation and hyperreactivity in mice.
Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lav | 2010 |
Pathology of gastrointestinal organs in a porcine model of cystic fibrosis.
Topics: Animals; Cell Proliferation; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; D | 2010 |
Anti-ulcerogenic effect of a whey protein isolate and collagen hydrolysates against ethanol ulcerative lesions on oral administration to rats.
Topics: Alkylation; Animals; Anti-Ulcer Agents; Carbenoxolone; Cattle; Collagen; Disease Models, Animal; Dru | 2010 |
Lipids control mucus production in cystic fibrosis.
Topics: Animals; Carbonic Anhydrase II; Carbonic Anhydrase IV; Cystic Fibrosis; Cystic Fibrosis Transmembran | 2010 |
Gastrointestinal protective effect of dietary spices during ethanol-induced oxidant stress in experimental rats.
Topics: Alkaloids; Animals; Antioxidants; Benzodioxoles; Capsaicin; Capsicum; Catalase; Cytoprotection; Diet | 2010 |
Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen.
Topics: Air Pollutants; Allergens; Animals; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchoalveolar L | 2010 |
Critical role of cytosolic phospholipase A2{alpha} in bronchial mucus hypersecretion in CFTR-deficient mice.
Topics: Animals; Arachidonic Acid; Bronchi; Cell Line; Chlorides; Cystic Fibrosis Transmembrane Conductance | 2010 |
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.
Topics: Animals; Animals, Newborn; Cystic Fibrosis; Disease Models, Animal; Ileus; Inflammation; Lung; Mecon | 2010 |
Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro.
Topics: Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regula | 2010 |
The overexpression of heparin-binding epidermal growth factor is responsible for Th17-induced airway remodeling in an experimental asthma model.
Topics: Adoptive Transfer; Airway Remodeling; Animals; Antibodies, Monoclonal; Asthma; Blotting, Western; Cy | 2010 |
Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models.
Topics: Achyrocline; Animals; Anti-Ulcer Agents; Brazil; Cimetidine; Cytoprotection; Disease Models, Animal; | 2010 |
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma.
Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flui | 2011 |
Protective effect of roxatidine against indomethacin-induced small intestinal mucosal injury in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Famotidine; Histamine H2 Antagonists | 2010 |
Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model.
Topics: Analysis of Variance; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokine | 2010 |
Repeated stress reduces mucociliary clearance in animals with chronic allergic airway inflammation.
Topics: Adrenal Glands; Animals; Bronchial Hyperreactivity; Cilia; Disease Models, Animal; Epithalamus; Guin | 2010 |
Exposing rodents to a combination of tobacco smoke and lipopolysaccharide results in an exaggerated inflammatory response in the lung.
Topics: Adrenal Cortex Hormones; Aminopyridines; Animals; Anti-Inflammatory Agents; Benzamides; Bronchoalveo | 2010 |
Effects of astragaloside IV on IFN-gamma level and prolonged airway dysfunction in a murine model of chronic asthma.
Topics: Animals; Asthma; Astragalus Plant; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chronic | 2011 |
Effects of clarithromycin and dexamethasone on mucus production in isografted rat trachea.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Clarithromycin; Dexamethasone; Disease Mod | 2011 |
Cigarette smoke suppresses Bik to cause epithelial cell hyperplasia and mucous cell metaplasia.
Topics: Animals; Blotting, Western; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Epithelial | 2011 |
Gastroprotective and ulcer healing effects of essential oil from Hyptis spicigera Lam. (Lamiaceae).
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Bicyclic Monoterpenes; Brazil; Bridged Bicyclo Compounds; C | 2011 |
Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation.
Topics: Animals; Antigens, CD; Blotting, Western; Cell Adhesion Molecules; Cells, Cultured; Cytokines; Disea | 2011 |
Swine models of cystic fibrosis reveal male reproductive tract phenotype at birth.
Topics: Animals; Animals, Genetically Modified; Animals, Newborn; Anions; Chloride-Bicarbonate Antiporters; | 2011 |
Indigofera suffruticosa Mill as new source of healing agent: involvement of prostaglandin and mucus and heat shock proteins.
Topics: Acetates; Animals; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Ethanol; Gastric Mucos | 2011 |
Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor.
Topics: Allergens; Animals; Asthma; Disease Models, Animal; Enzyme Inhibitors; Gene Knock-In Techniques; Gro | 2011 |
Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Butanols; Catalase; Convolvulaceae; Cytoprotection; Disease Mod | 2011 |
Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; Artemisinins; Artesunate; Asthma; Bronchi; Broncho | 2011 |
IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; CD8-Positive T-Lymphocytes; Disease Models, Anim | 2011 |
Gastroprotective activity of Zanthoxylum rhoifolium Lam. in animal models.
Topics: Animals; Anti-Ulcer Agents; Catalase; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Eth | 2011 |
In vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Bauhinia; Chromatography, High Pressure Liquid; Di | 2011 |
Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae).
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Diterpenes; Ethanol; Gastric Acid; Hydrogen-Ion | 2011 |
Environmental tobacco smoke and progesterone alter lung inflammation and mucous metaplasia in a mouse model of allergic airway disease.
Topics: Allergens; Animals; Asthma; Disease Models, Animal; Female; Humans; Hypersensitivity, Immediate; Mal | 2012 |
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals.
Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An | 2012 |
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals.
Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An | 2012 |
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals.
Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An | 2012 |
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals.
Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An | 2012 |
Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.
Topics: Administration, Oral; Analgesics; Animals; Chlorides; Chromosomes, Artificial, Bacterial; Colon; Dis | 2012 |
Gastroprotective effect of Senecio candicans DC on experimental ulcer models.
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Anti-Ulcer Agents; Antioxidants; Biphenyl Compounds; | 2012 |
Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.
Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Adhesion Molecules; Cell Coun | 2012 |
Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Arbutin; Aspirin; Cell Line; Cytoprotection; Disease Model | 2012 |
Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction.
Topics: Airway Obstruction; Animals; Disease Models, Animal; Epithelial Sodium Channels; Lung Diseases, Obst | 2012 |
Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation.
Topics: Animals; Bacterial Infections; Disease Models, Animal; Epithelial Sodium Channels; Lung; Mice; Mice, | 2012 |
Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation.
Topics: Adoptive Transfer; Allergens; Animals; Asthma; Cytokines; Disease Models, Animal; Gene Expression Pr | 2012 |
Microbiological and mucociliary properties of the ethanol extract of Hymenocardia acida on selected respiratory clinical isolates.
Topics: Ammonium Chloride; Animals; Anti-Bacterial Agents; Bacteria; Cilia; Columbidae; Disease Models, Anim | 2011 |
Multiple peptidoglycan modification networks modulate Helicobacter pylori's cell shape, motility, and colonization potential.
Topics: Animals; Bacterial Physiological Phenomena; Bacterial Proteins; Cell Wall; Disease Models, Animal; F | 2012 |
Components of Streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells.
Topics: Adoptive Transfer; Animals; Asthma; Bacterial Capsules; Bacterial Proteins; Disease Models, Animal; | 2012 |
CD137 deficiency does not affect development of airway inflammation or respiratory tolerance induction in murine models.
Topics: Allergens; Animals; Asthma; Cytokines; Disease Models, Animal; Eosinophils; Humans; Immune Tolerance | 2012 |
Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis.
Topics: Animals; Dextran Sulfate; Disease Models, Animal; Enterocolitis; Inflammation; Intestinal Mucosa; In | 2012 |
Rosuvastatin attenuates mucus secretion in a murine model of chronic asthma by inhibiting the gamma-aminobutyric acid type A receptor.
Topics: Animals; Asthma; Chronic Disease; Disease Models, Animal; Female; Fluorobenzenes; GABA-A Receptor An | 2012 |
Characteristic comparison of three rat models induced by cigarette smoke or combined with LPS: to establish a suitable model for study of airway mucus hypersecretion in chronic obstructive pulmonary disease.
Topics: Animals; Bronchi; Disease Models, Animal; ErbB Receptors; Histone Deacetylase 2; Lipopolysaccharides | 2012 |
Gastroprotective activity of carvacrol on experimentally induced gastric lesions in rodents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Cymenes; Disease | 2012 |
Effects and mechanism of arsenic trioxide on reversing the asthma pathologies including Th17-IL-17 axis in a mouse model.
Topics: Animals; Anti-Asthmatic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Asthma; Bronchial Hyperreac | 2012 |
Antiulcerogenic effect of Croton urucurana Baillon bark.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Croton; Disease Models, Animal; Ethanol; Female; Gastric Ac | 2012 |
Comparative analysis of gastric bacterial microbiota in Mongolian gerbils after long-term infection with Helicobacter pylori.
Topics: Animals; Biodiversity; Disease Models, Animal; DNA Primers; Gastric Juice; Gerbillinae; Helicobacter | 2012 |
Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma.
Topics: Anesthetics, Local; Animals; Asthma; Bronchi; Disease Models, Animal; Fibrosis; GATA3 Transcription | 2012 |
In vivo determination of mouse olfactory mucus cation concentrations in normal and inflammatory states.
Topics: Adult; Allergens; Animals; Cations; Disease Models, Animal; Eosinophil Major Basic Protein; Eosinoph | 2012 |
SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation.
Topics: 3' Untranslated Regions; Airway Obstruction; Animals; Antiporters; Asthma; Bronchitis; Calcium; Chil | 2012 |
Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf.
Topics: Animals; Anti-Ulcer Agents; Bauhinia; Chloroform; Chromatography, High Pressure Liquid; Cytoprotecti | 2012 |
Possible biochemical effects following inhibition of ethanol-induced gastric mucosa damage by Gymnema sylvestre in male Wistar albino rats.
Topics: Animals; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; DNA; Dose-Response Relationship, | 2012 |
Gastroprotective activity of the ethanolic extract and hexane phase of Combretum duarteanum Cambess. (Combretaceae).
Topics: Animals; Anti-Ulcer Agents; Combretum; Cytoprotection; Disease Models, Animal; Dose-Response Relatio | 2013 |
Gastroprotective mechanisms of the chloroform and ethyl acetate phases of Praxelis clematidea (Griseb.) R.M.King & H.Robinson (Asteraceae).
Topics: Acetates; Animals; Anti-Ulcer Agents; Asteraceae; Biomarkers; Chloroform; Cytoprotection; Disease Mo | 2013 |
IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Stres | 2013 |
The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunoglobulin E; | 2012 |
Alleviating effects of Lactobacillus strains on pathogenic Vibrio parahaemolyticus-induced intestinal fluid accumulation in the mouse model.
Topics: Analysis of Variance; Animals; Bacterial Adhesion; Disease Models, Animal; Female; Histocytochemistr | 2013 |
Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice.
Topics: Animals; Antigens, Dermatophagoides; Asthma; Complement Activation; Cytokines; Disease Models, Anima | 2013 |
A small molecule inhibitor of redox-regulated NF-kappa B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model.
Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar L | 2002 |
Effect of polysaccharides from Angelica sinensis on gastric ulcer healing.
Topics: Angelica sinensis; Angiogenesis Inhibitors; Animals; Anti-Ulcer Agents; Disease Models, Animal; Drug | 2003 |
A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse.
Topics: Adoptive Transfer; Aerosols; Allergens; Animals; Bronchial Hyperreactivity; CD4-Positive T-Lymphocyt | 2003 |
CXCR2 regulates respiratory syncytial virus-induced airway hyperreactivity and mucus overproduction.
Topics: Animals; Bronchial Hyperreactivity; Bronchiolitis, Viral; Disease Models, Animal; Female; Goblet Cel | 2003 |
Spontaneous remission of edema and regranulation of goblet cells in rat tracheae after capsaicin-induced acute inflammation.
Topics: Acute Disease; Animals; Capsaicin; Cytoplasmic Granules; Disease Models, Animal; Edema; Goblet Cells | 2003 |
In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Carcinoma, Mucoepidermoid; Cell Line, Tumor; Clarithromy | 2003 |
[Effect of azithromycin on mucus secretion from nasal epithelium].
Topics: Animals; Anti-Bacterial Agents; Azithromycin; Cells, Cultured; Depression, Chemical; Disease Models, | 2003 |
A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma.
Topics: Animals; Asthma; Bronchi; Bronchial Provocation Tests; Cytoplasmic Granules; Disease Models, Animal; | 2004 |
Gastric antiulcer activity of Syngonanthus arthrotrichus SILVEIRA.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Bethanechol; Cimetidine; Diseas | 2004 |
Complex role of the IL-4 receptor alpha in a murine model of airway inflammation: expression of the IL-4 receptor alpha on nonlymphoid cells of bone marrow origin contributes to severity of inflammation.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid; Disease Model | 2004 |
Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice.
Topics: Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Anima | 2004 |
Breath condensate hydrogen peroxide correlates with both airway cytology and epithelial lining fluid ascorbic acid concentration in the horse.
Topics: Airway Obstruction; Animals; Ascorbic Acid; Breath Tests; Bronchoalveolar Lavage Fluid; Bronchoscopy | 2004 |
Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; | 2004 |
Expiratory chest compression for atelectasis: No harm, no foul-oops!
Topics: Animals; Carbon Dioxide; Combined Modality Therapy; Disease Models, Animal; Intubation, Intratrachea | 2004 |
Effects of expiratory rib cage compression combined with endotracheal suctioning on gas exchange in mechanically ventilated rabbits with induced atelectasis.
Topics: Animals; Carbon Dioxide; Combined Modality Therapy; Disease Models, Animal; Female; Intubation, Intr | 2004 |
Reduced expression of transforming growth factor beta 1 exacerbates pathology in an experimental asthma model.
Topics: Animals; Asthma; Cytokines; Disease Models, Animal; Female; Heterozygote; Immunization; Immunoglobul | 2005 |
Beneficial effect of auto-aggregating Lactobacillus crispatus on experimentally induced colitis in mice.
Topics: Animals; Bacterial Adhesion; Dextran Sulfate; Disease Models, Animal; Feces; Inflammatory Bowel Dise | 2005 |
An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Movement; Chromones; C | 2005 |
[Effects of interleukin-13 on the gob-5 and MUC5AC expression in lungs of a murine asthmatic model].
Topics: Animals; Asthma; Chloride Channels; Disease Models, Animal; Immunohistochemistry; Interleukin-13; Ma | 2004 |
[The preventive effect of bacillus Calmette-Guerin vaccination in early life on airway inflammation and mucus production in a murine model of asthma].
Topics: Animals; Asthma; BCG Vaccine; Bronchi; Disease Models, Animal; Lung; Mice; Mice, Inbred C57BL; Mucin | 2005 |
Allophylus serratus: a plant with potential anti-ulcerogenic activity.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Cold Temperature; Disease Models, Animal; | 2005 |
Menadione protects gastric mucosa against ethanol-induced ulcers.
Topics: Administration, Oral; Animals; Antifibrinolytic Agents; Disease Models, Animal; Dose-Response Relati | 2005 |
Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma.
Topics: Animals; Asthma; Cells, Cultured; Chloride Channels; Disease Models, Animal; Female; Gastrointestina | 2005 |
Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Apoptosis; Asthma; Bronchial Hyperreactivity; Disease | 2005 |
Characteristic features of allergic airway inflammation in a murine model of infantile asthma.
Topics: Age Factors; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Di | 2005 |
Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1.
Topics: Animals; Antigen-Antibody Reactions; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid | 2006 |
Cigarette smoke suppresses Th1 cytokine production and increases RSV expression in a neonatal model.
Topics: Animals; Animals, Newborn; Cytokines; Disease Models, Animal; Female; Inflammation Mediators; Interl | 2006 |
Culture of murine nasal epithelia: model for cystic fibrosis.
Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cystic Fibrosis; Disease Models, Animal; Ele | 2006 |
Effect of disodium cromoglycate on airway mucus secretion during antigen-induced late asthmatic responses in a murine model of asthma.
Topics: Airway Obstruction; Animals; Anti-Asthmatic Agents; Antigens; Asthma; Bronchoalveolar Lavage Fluid; | 2005 |
Anti-T-cell Ig and mucin domain-containing protein 1 antibody decreases TH2 airway inflammation in a mouse model of asthma.
Topics: Animals; Antibodies, Monoclonal; Asthma; Cytokines; Disease Models, Animal; Female; Hepatitis A Viru | 2005 |
Eradication of small intestinal bacterial overgrowth in the cystic fibrosis mouse reduces mucus accumulation.
Topics: Animals; Anti-Infective Agents; Bacteria; Ciprofloxacin; Cystic Fibrosis; Cystic Fibrosis Transmembr | 2006 |
Mucus in chronic airway diseases: sorting out the sticky details.
Topics: Animals; Disease Models, Animal; Epithelial Cells; ErbB Receptors; Humans; Interleukin-13; Lung Dise | 2006 |
Erratum: name change.
Topics: Animals; Asthma; Chloride Channels; Disease Models, Animal; Mice; Mucoproteins; Mucus; Respiratory M | 2006 |
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma.
Topics: Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Dendritic Cells; Disease Models, Ani | 2006 |
Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness.
Topics: Animals; Asthma; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Embryo, Mammalian; Eosinop | 2006 |
Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma.
Topics: Acetates; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disea | 2006 |
Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation.
Topics: Airway Resistance; Animals; Antigens; Bronchoalveolar Lavage Fluid; Chemokines; Chloride Channels; D | 2006 |
The effects of low dose leukotriene receptor antagonist therapy on airway remodeling and cysteinyl leukotriene expression in a mouse asthma model.
Topics: Acetates; Airway Obstruction; Animals; Anti-Asthmatic Agents; Asthma; Collagen; Cyclopropanes; Cyste | 2006 |
Human metapneumovirus infection induces long-term pulmonary inflammation associated with airway obstruction and hyperresponsiveness in mice.
Topics: Animals; Disease Models, Animal; Histocytochemistry; Lung; Lung Diseases, Obstructive; Metapneumovir | 2006 |
Death receptor-6 regulates the development of pulmonary eosinophilia and airway inflammation in a mouse model of asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Interferon-gamma; Mic | 2006 |
Follistatin is a candidate endogenous negative regulator of activin A in experimental allergic asthma.
Topics: Activins; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Follistatin | 2006 |
The spontaneously hypertensive rat: an experimental model of sulfur dioxide-induced airways disease.
Topics: Acetylglucosaminidase; Administration, Inhalation; Animals; Bronchitis; Bronchoalveolar Lavage Fluid | 2006 |
A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation.
Topics: Allergens; Animals; Bronchial Hyperreactivity; Cell Movement; Chemokine CCL11; Chemokines, CC; Chron | 2006 |
[Effects of glucocorticoid on airway mucus secretion in asthma: experiment with asthmatic mouse model].
Topics: Aluminum Hydroxide; Animals; Asthma; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, An | 2006 |
Gastroprotective effects of DA-6034, a new flavonoid derivative, in various gastric mucosal damage models.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Centra | 2007 |
A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Biological Availability; Bronchitis; Bronchoalveolar | 2007 |
The tick salivary protein, Salp15, inhibits the development of experimental asthma.
Topics: Adjuvants, Immunologic; Animals; Asthma; Bronchial Hyperreactivity; CD4-Positive T-Lymphocytes; Dise | 2007 |
Plasminogen is an important regulator in the pathogenesis of a murine model of asthma.
Topics: Animals; Antifibrinolytic Agents; Asthma; Bronchoalveolar Lavage Fluid; Collagen; Disease Models, An | 2007 |
Effects of laxative and N-acetylcysteine on mucus accumulation, bacterial load, transit, and inflammation in the cystic fibrosis mouse small intestine.
Topics: Acetylcysteine; Animals; Bacteria; Body Weight; Cathartics; Cystic Fibrosis; Disease Models, Animal; | 2007 |
Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT-6 peptide.
Topics: Acute Disease; Administration, Intranasal; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Mo | 2007 |
Anti-inflammatory and anti-allergic effects of kefir in a mouse asthma model.
Topics: Administration, Oral; Animals; Asthma; Bronchial Hyperreactivity; Cultured Milk Products; Cytokines; | 2007 |
The involvement of type 1a angiotensin II receptors in the regulation of airway inflammation in a murine model of allergic asthma.
Topics: Animals; Asthma; Bronchitis; Bronchoalveolar Lavage Fluid; Cell Count; Cell Differentiation; Cytokin | 2007 |
Airway responses to esophageal acidification.
Topics: Airway Resistance; Animals; Bronchi; Cats; Disease Models, Animal; Esophagus; Female; Gastroesophage | 2008 |
Glutamine preferentially inhibits T-helper type 2 cell-mediated airway inflammation and late airway hyperresponsiveness through the inhibition of cytosolic phospholipase A(2) activity in a murine asthma model.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Cytokines; Disease Models, Animal; Eosinophi | 2008 |
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.
Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Gene Transfer Techniques; Genetic Therapy; Gob | 2008 |
Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation.
Topics: Animals; Antibody Formation; Bronchial Hyperreactivity; Chemokines; Chemotactic Factors; Dendritic C | 2008 |
EP4 agonist inhibits lipopolysaccharide-induced mucus secretion in airway epithelial cells.
Topics: Animals; Carcinoma, Mucoepidermoid; Cell Line, Tumor; Dinoprostone; Disease Models, Animal; Gene Exp | 2008 |
Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.
Topics: Adenoviridae; Adenoviridae Infections; Airway Obstruction; Animals; Cell Culture Techniques; Cell Di | 2008 |
Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation.
Topics: Allergens; Animals; Cytokines; Disease Models, Animal; Inflammation; Isoquinolines; Lung; Mice; Mice | 2008 |
Gastroprotective activity of Eriobotrya japonica seed extract on experimentally induced gastric lesions in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, D | 2008 |
Successful prevalidation of the slug mucosal irritation test to assess the eye irritation potency of chemicals.
Topics: Animal Use Alternatives; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Eye; Irr | 2008 |
Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease.
Topics: Aged; Animals; Asthma; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Epithelial Cells; Fe | 2008 |
Mucous obstruction and airway hyperresponsiveness in mice.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Disease Models, Animal; Mic | 2008 |
Symposium: Host defences.
Topics: Acquired Immunodeficiency Syndrome; Airway Resistance; Animals; Antigens; Cilia; Disease Models, Ani | 1983 |
The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland.
Topics: Animals; Calcium; Cystic Fibrosis; Disease Models, Animal; Drug Interactions; Electron Probe Microan | 1984 |
Hypersecretion of mucus glycoprotein by the gallbladder epithelium in experimental cholelithiasis.
Topics: Animals; Cholelithiasis; Cholestanol; Cholesterol; Cholic Acids; Disease Models, Animal; Epithelium; | 1981 |
Control and modulation of airway epithelial cells and their secretions.
Topics: Animals; Asthma; Bronchitis; Chronic Disease; Cystic Fibrosis; Disease Models, Animal; Dogs; Epithel | 1983 |
Experimental chronic bronchitis.
Topics: Animals; Bronchi; Bronchitis; Chronic Disease; Cricetinae; Disease Models, Animal; Dogs; Epithelium; | 1983 |
Effect of dexamethasone on antigen-induced high molecular weight glycoconjugate secretion in allergic guinea pigs.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Eosinophils; G | 1995 |
Hyperplastic effects of aerosolized sodium metabisulfite on rat airway mucus-secretory epithelial cells.
Topics: Aerosols; Animals; Disease Models, Animal; Epithelium; Glycoproteins; Hyperplasia; Hypertrophy; Lung | 1994 |
Antiulcerogenicity of the flavonoid fraction from Bidens aurea: comparison with ranitidine and omeprazole.
Topics: Acute Disease; Animals; Anti-Ulcer Agents; Cold Temperature; Disease Models, Animal; Female; Flavono | 1994 |
Influence of simulated mucus on cough sounds in cats.
Topics: Animals; Cats; Cough; Disease Models, Animal; Female; Male; Mucus; Sound | 1993 |
MAO-A and -B inhibitors selectively alter Xenopus mucus-induced behaviors of snakes.
Topics: Analysis of Variance; Animals; Behavior, Animal; Clorgyline; Disease Models, Animal; Movement Disord | 1993 |
The effects of a cysteinyl leukotriene antagonist (ONO-1078) on antigen-induced responses in allergic sheep.
Topics: Airway Resistance; Animals; Antigens, Helminth; Ascaris; Bronchoalveolar Lavage Fluid; Bronchoconstr | 1993 |
Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats.
Topics: Animals; Cell Division; Colitis; Disease Models, Animal; Fibroblast Growth Factor 10; Fibroblast Gro | 1996 |
Evaluation of cecal ligation as a model of mucoid enteropathy in specific-pathogen-free rabbits.
Topics: Animals; Cecal Diseases; Cecum; Colon; Disease Models, Animal; Inflammation; Intestinal Diseases; Li | 1996 |
The importance of leukotrienes in airway inflammation in a mouse model of asthma.
Topics: 5-Lipoxygenase-Activating Proteins; Allergens; Animals; Asthma; Bronchial Provocation Tests; Broncho | 1996 |
Cytoprotective activity in the gastric mucosa of rats exposed to carbon tetrachloride-induced liver injury.
Topics: Animals; Carbon Tetrachloride; Dinoprostone; Disease Models, Animal; Drug Resistance; Ethanol; Gastr | 1997 |
Studies on the antisecretory, gastric anti-ulcer and cytoprotective properties of glycine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Caustics; Disease Models, Anima | 1997 |
Early stages in the development of goblet cells in the paranasal sinuses: a multimethodological study in the rabbit.
Topics: Administration, Topical; Animals; Capsaicin; Cell Count; Cell Differentiation; Cytoplasmic Granules; | 1998 |
Inflammation and a thickened mucus layer in mice with cholesterol gallstones.
Topics: Animals; Cholecystitis; Cholelithiasis; Cholesterol; Cholesterol, Dietary; Cholic Acid; Cholic Acids | 1998 |
Molecular pathophysiology of cystic fibrosis based on the rescued knockout mouse model.
Topics: Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Anima | 1998 |
Mucus transportability: the bovine trachea and frog palate models compared.
Topics: Animals; Anura; Cattle; Cystic Fibrosis; Disease Models, Animal; Humans; Mucociliary Clearance; Mucu | 1998 |
[Protective effects of teprenone and gefarnate against taurocholate/hydrochloric acid-induced acute gastric mucosal lesions in rats].
Topics: Acute Disease; Animals; Anti-Ulcer Agents; Disease Models, Animal; Diterpenes; Dose-Response Relatio | 1998 |
T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production.
Topics: Animals; Asthma; Disease Models, Animal; Eosinophilia; Flow Cytometry; Hypersensitivity; Inflammatio | 1999 |
Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma.
Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar L | 2000 |
Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Allergens; Animals; Anti-Inflammatory Agents, Non-St | 2000 |
Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; | 2000 |
Evaluation of the gastroprotective activity of cordatin, a diterpene isolated from Aparisthmium cordatum (Euphorbiaceae).
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Disease Models, Animal; Diterpe | 2000 |
Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma.
Topics: Animals; Asthma; Cell Line; Chloride Channels; Cloning, Molecular; Disease Models, Animal; Epitheliu | 2001 |
Synergy of histone-derived peptides of coho salmon with lysozyme and flounder pleurocidin.
Topics: Aeromonas; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Fish Diseases | 2001 |
Suppression of asthma-like responses in different mouse strains by oral tolerance.
Topics: Administration, Inhalation; Administration, Oral; Animals; Antibodies; Antigens; Asthma; Bronchial P | 2001 |
Sulfated polysaccharides, but not cellulose, increase colonic mucus in rats with loperamide-induced constipation.
Topics: Alginates; Animals; Carrageenan; Cellulose; Chondroitin Sulfates; Colon; Constipation; Dietary Fiber | 2001 |
Murine cytomegalovirus infection alters Th1/Th2 cytokine expression, decreases airway eosinophilia, and enhances mucus production in allergic airway disease.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Cytomegalovirus Infections; Disease Models | 2001 |
The CF salt controversy: in vivo observations and therapeutic approaches.
Topics: Aerosols; Amiloride; Animals; Cells, Cultured; Cystic Fibrosis; Disease Models, Animal; Diuretics; G | 2001 |
Exposure to diesel exhaust exacerbates allergen-induced airway responses in guinea pigs.
Topics: Allergens; Analysis of Variance; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavag | 2001 |
In vivo microdialysis for determination of nasal liquid ion composition.
Topics: Animals; Chlorides; Cystic Fibrosis; Disease Models, Animal; Electrodes; Female; Ions; Male; Membran | 2002 |
Inflammatory responses and mucus secretion in rats with acute bronchiolitis induced by nickel chloride.
Topics: Animals; Bronchiolitis; Disease Models, Animal; Inflammation; Inhalation Exposure; Male; Mucus; Nick | 2002 |
Studies on the pathogenesis of diet-induced dog gallstones.
Topics: Amino Acids; Animals; Bile; Bile Pigments; Bilirubin; Cholelithiasis; Cholesterol, Dietary; Diet; Di | 1977 |
Modification of mucus in animal models of disease.
Topics: Animals; Bronchi; Disease Models, Animal; Epithelium; Glycoproteins; Hydrogen-Ion Concentration; Hyp | 1977 |
Animal models in clinical disease.
Topics: Animals; Cytoplasmic Granules; Disease Models, Animal; Exocrine Glands; Glycoproteins; Mucus; Rats; | 1978 |
The parasympathetic nervous system in airways disease.
Topics: Animals; Asthma; Bronchial Spasm; Disease Models, Animal; Dogs; Humans; Lung; Mucus; Parasympathetic | 1979 |
An animal model for cystic fibrosis made by gene targeting.
Topics: Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Digestive System; Dis | 1992 |
Experimental sinusitis in rabbits induced by aerobic and anaerobic bacteria: models for research in sinusitis.
Topics: Animals; Bacteroides fragilis; Bacteroides Infections; Blood Flow Velocity; Disease Models, Animal; | 1991 |
The oral mucosa of the MRL/I mouse: a synoptic picture of systemic autoimmune disorders.
Topics: Animals; Autoimmune Diseases; Capillaries; Connective Tissue; Disease Models, Animal; Epithelium; Ex | 1991 |
Mouse model for colonization and disease caused by enterohemorrhagic Escherichia coli O157:H7.
Topics: Animals; Bacterial Outer Membrane Proteins; Disease Models, Animal; Escherichia coli; Escherichia co | 1990 |
A nasal allergy model developed in the guinea pig by intranasal application of 2,4-toluene diisocyanate.
Topics: Administration, Intranasal; Animals; Cyanates; Disease Models, Animal; Guinea Pigs; Histamine; Male; | 1988 |
Common bile duct ligation in rabbit: a new model of acute cholecystitis description of histology and bile analysis.
Topics: Acute Disease; Animals; Bile; Bile Acids and Salts; Cholecystitis; Common Bile Duct; Disease Models, | 1988 |
Changes in glycoconjugates in rat submandibular gland after chronic treatment with reserpine and isoproterenol.
Topics: Animals; Cystic Fibrosis; Cytoplasmic Granules; Disease Models, Animal; Glycoconjugates; Isoproteren | 1988 |
Transition from normal to hypersecretory bronchial mucus in a canine model of bronchitis: changes in yield and composition.
Topics: Animals; Bronchi; Bronchitis; Disease Models, Animal; Dogs; Glycoproteins; Glycosaminoglycans; Mucus | 1988 |
Pharmacodynamic mechanism and therapeutic activity of ambroxol in animal experiments.
Topics: Albuterol; Ambroxol; Animals; Bromhexine; Cilia; Disease Models, Animal; Guinea Pigs; In Vitro Techn | 1987 |
Simian model for the evaluation of immunity to influenza.
Topics: Aerosols; Animals; Disease Models, Animal; Erythrocytes; Guinea Pigs; Haplorhini; Hemagglutination I | 1974 |
Ingestion of asbestos.
Topics: Animals; Asbestos; Diet; Disease Models, Animal; Dogs; Guinea Pigs; Haplorhini; Mucus; Rabbits; Rats | 1974 |
An interpretive summary of the Bermuda workshop.
Topics: Animals; Basement Membrane; Cell Division; Congresses as Topic; Disease Models, Animal; Environmenta | 1970 |
Experimental chronic bronchitis. Pathology in the dog.
Topics: Air; Animals; Bronchi; Bronchitis; Chronic Disease; Cilia; Disease Models, Animal; Dogs; Environment | 1974 |
Evaluation of model systems for study of airway epithelium, cilia, and mucus.
Topics: Animals; Bronchi; Bronchitis; Cilia; Disease Models, Animal; Dogs; Epithelium; Glycoproteins; Haplor | 1970 |
Experimental requirements for the toxicological evaluation of tobacco smoke in the respiratory system.
Topics: Air Pollution; Animals; Cats; Cilia; Disease Models, Animal; Environmental Exposure; Humans; Macroph | 1969 |
The canine tracheal pouch. A model for use in respiratory mucus research.
Topics: Animals; Disease Models, Animal; Dogs; Methods; Models, Biological; Mucus; Muscle Contraction; Muscl | 1970 |
Studies of lung defense to infections in inhalation toxicology.
Topics: Aerosols; Bacteria; Bacteriolysis; Cilia; Disease Models, Animal; Environmental Exposure; Epithelium | 1970 |
Integrated defense mechanisms in models of chronic pulmonary disease.
Topics: Aerosols; Animals; Antibodies; Bronchi; Chronic Disease; Cilia; Disease Models, Animal; Infections; | 1970 |
Experimental bronchitis in animals due to sulphur dioxide and cigarette smoke. An automated quantitative study.
Topics: Animals; Bronchitis; Disease Models, Animal; Germ-Free Life; Lung; Methods; Models, Biological; Mucu | 1970 |