guaifenesin has been researched along with Colitis in 67 studies
Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Arctigenin was demonstrated to promote the mucus secretion and maintain the integrity of mucus barrier, which might be achieved by an increase in the number of goblet cells via inhibiting apoptosis." | 5.72 | Phytoestrogen arctigenin preserves the mucus barrier in inflammatory bowel diseases by inhibiting goblet cell apoptosis via the ERβ/TRIM21/PHB1 pathway. ( Dai, Y; Fang, YL; Lv, CJ; Qiao, SM; Tao, Y; Wei, ZF; Xia, YF; Yue, MF; Yun, XM, 2022) |
| "Pirenzepine has been widely used for the treatment of gastric and duodenal ulcer." | 5.27 | Pirenzepine as anti-inflammatory drug in a model of experimental colitis in rat. ( Bustos-Fernández, L; Celener, D; González, E; Hamamura, S; Kofoed, JA; Ledesma de Paolo, MI; Schiffrin, E, 1987) |
| "Current therapeutics for ulcerative colitis (UC) have limitations." | 1.91 | Modified Gegen Qinlian decoction ameliorates DSS-induced chronic colitis in mice by restoring the intestinal mucus barrier and inhibiting the activation of γδT17 cells. ( Huang, J; Liu, Z; Ma, J; Tang, X; Wang, F; Wang, Y; Yang, X; Zhang, J, 2023) |
| "Arctigenin was demonstrated to promote the mucus secretion and maintain the integrity of mucus barrier, which might be achieved by an increase in the number of goblet cells via inhibiting apoptosis." | 1.72 | Phytoestrogen arctigenin preserves the mucus barrier in inflammatory bowel diseases by inhibiting goblet cell apoptosis via the ERβ/TRIM21/PHB1 pathway. ( Dai, Y; Fang, YL; Lv, CJ; Qiao, SM; Tao, Y; Wei, ZF; Xia, YF; Yue, MF; Yun, XM, 2022) |
| "Chronic colitis was induced in C57BL/6 mice by administration of dextran sulfate sodium (DSS) for 27 days." | 1.48 | Peroxisome proliferator-activated receptor gamma activation promotes intestinal barrier function by improving mucus and tight junctions in a mouse colitis model. ( Cheng, L; Yang, J; Zhao, J; Zhao, R; Zhu, L, 2018) |
| "Pirenzepine has been widely used for the treatment of gastric and duodenal ulcer." | 1.27 | Pirenzepine as anti-inflammatory drug in a model of experimental colitis in rat. ( Bustos-Fernández, L; Celener, D; González, E; Hamamura, S; Kofoed, JA; Ledesma de Paolo, MI; Schiffrin, E, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (20.90) | 18.7374 |
| 1990's | 3 (4.48) | 18.2507 |
| 2000's | 6 (8.96) | 29.6817 |
| 2010's | 22 (32.84) | 24.3611 |
| 2020's | 22 (32.84) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Z | 2 |
| Shen, X | 1 |
| Zhou, Q | 1 |
| Zhan, Q | 1 |
| Xu, X | 1 |
| Chen, Q | 1 |
| An, F | 1 |
| Sun, J | 1 |
| Reyes Nicolás, V | 1 |
| Allaire, JM | 1 |
| Alfonso, AB | 1 |
| Pupo Gómez, D | 1 |
| Pomerleau, V | 1 |
| Giroux, V | 1 |
| Boudreau, F | 1 |
| Perreault, N | 1 |
| Sharpen, JDA | 1 |
| Dolan, B | 1 |
| Nyström, EEL | 2 |
| Birchenough, GMH | 2 |
| Arike, L | 3 |
| Martinez-Abad, B | 2 |
| Johansson, MEV | 2 |
| Hansson, GC | 6 |
| Recktenwald, CV | 1 |
| Fang, J | 1 |
| Zhang, Z | 1 |
| Cheng, Y | 1 |
| Yang, H | 1 |
| Zhang, H | 2 |
| Xue, Z | 1 |
| Lu, S | 1 |
| Dong, Y | 1 |
| Song, C | 1 |
| Zhang, X | 5 |
| Zhou, Y | 2 |
| Zangara, MT | 1 |
| Ponti, AK | 1 |
| Miller, ND | 1 |
| Engelhart, MJ | 1 |
| Ahern, PP | 1 |
| Sangwan, N | 1 |
| McDonald, C | 1 |
| Tao, Y | 1 |
| Qiao, SM | 1 |
| Lv, CJ | 1 |
| Yun, XM | 1 |
| Yue, MF | 1 |
| Fang, YL | 1 |
| Wei, ZF | 1 |
| Dai, Y | 1 |
| Xia, YF | 1 |
| Wu, Z | 1 |
| Liu, X | 5 |
| Huang, S | 1 |
| Li, T | 1 |
| Pang, J | 1 |
| Zhao, J | 2 |
| Chen, L | 2 |
| Zhang, B | 4 |
| Wang, J | 5 |
| Han, D | 1 |
| Yang, D | 1 |
| Jacobson, A | 1 |
| Meerschaert, KA | 1 |
| Sifakis, JJ | 1 |
| Wu, M | 1 |
| Chen, X | 2 |
| Yang, T | 1 |
| Anekal, PV | 1 |
| Rucker, RA | 1 |
| Sharma, D | 1 |
| Sontheimer-Phelps, A | 1 |
| Wu, GS | 1 |
| Deng, L | 1 |
| Anderson, MD | 1 |
| Choi, S | 1 |
| Neel, D | 1 |
| Lee, N | 1 |
| Kasper, DL | 1 |
| Jabri, B | 1 |
| Huh, JR | 1 |
| Johansson, M | 1 |
| Thiagarajah, JR | 1 |
| Riesenfeld, SJ | 1 |
| Chiu, IM | 1 |
| Zhao, C | 3 |
| Li, X | 7 |
| Zhang, Y | 4 |
| Yin, J | 3 |
| Wang, S | 4 |
| Ma, J | 2 |
| Zhang, J | 3 |
| Wang, Y | 2 |
| Huang, J | 1 |
| Yang, X | 1 |
| Liu, Z | 1 |
| Wang, F | 1 |
| Tang, X | 1 |
| Fang, YX | 1 |
| Liu, YQ | 1 |
| Hu, YM | 1 |
| Yang, YY | 1 |
| Zhang, DJ | 1 |
| Jiang, CH | 1 |
| Wang, JH | 1 |
| Wang, Q | 1 |
| Xu, K | 1 |
| Cai, X | 1 |
| Wang, C | 1 |
| Cao, Y | 1 |
| Xiao, J | 1 |
| Grey, MJ | 1 |
| Zhou, X | 1 |
| Shi, W | 1 |
| Aviello, G | 1 |
| Singh, AK | 1 |
| O'Neill, S | 1 |
| Conroy, E | 1 |
| Gallagher, W | 1 |
| D'Agostino, G | 1 |
| Walker, AW | 1 |
| Bourke, B | 1 |
| Scholz, D | 1 |
| Knaus, UG | 1 |
| Koumangoye, R | 1 |
| Omer, S | 1 |
| Kabeer, MH | 1 |
| Delpire, E | 1 |
| Lian, Q | 1 |
| Yan, S | 1 |
| Yin, Q | 1 |
| Yan, C | 1 |
| Zheng, W | 1 |
| Gu, W | 1 |
| Zhao, X | 1 |
| Fan, W | 1 |
| Ma, L | 1 |
| Ling, Z | 1 |
| Liu, J | 1 |
| Li, J | 2 |
| Sun, B | 1 |
| Huang, L | 1 |
| Sun, TY | 1 |
| Hu, LJ | 1 |
| Hu, SL | 1 |
| Sun, HM | 1 |
| Zhao, FQ | 1 |
| Wu, B | 1 |
| Yang, S | 1 |
| Ji, FQ | 1 |
| Zhou, DS | 1 |
| Placet, M | 1 |
| Molle, CM | 1 |
| Arguin, G | 1 |
| Geha, S | 1 |
| Gendron, FP | 1 |
| Nonnecke, EB | 1 |
| Castillo, PA | 1 |
| Svensson, F | 1 |
| Bevins, CL | 1 |
| Yu, L | 1 |
| Zhao, D | 1 |
| Nian, Y | 1 |
| Li, C | 1 |
| Yi, J | 1 |
| Liu, Y | 1 |
| Yu, Z | 1 |
| Chen, S | 1 |
| Luo, J | 1 |
| Kim, G | 1 |
| Chen, ES | 1 |
| Xiao, S | 1 |
| Snapper, SB | 1 |
| Bao, B | 1 |
| An, D | 1 |
| Blumberg, RS | 1 |
| Lin, CH | 1 |
| Zhong, J | 1 |
| Liu, K | 1 |
| Li, Q | 1 |
| Wu, C | 1 |
| Kuchroo, VK | 1 |
| Glymenaki, M | 1 |
| Singh, G | 1 |
| Brass, A | 1 |
| Warhurst, G | 1 |
| McBain, AJ | 1 |
| Else, KJ | 1 |
| Cruickshank, SM | 1 |
| Zhao, R | 1 |
| Cheng, L | 1 |
| Yang, J | 1 |
| Zhu, L | 1 |
| Ahmed, I | 1 |
| Roy, BC | 1 |
| Raach, RT | 1 |
| Owens, SM | 1 |
| Xia, L | 3 |
| Anant, S | 1 |
| Sampath, V | 1 |
| Umar, S | 1 |
| Laudisi, F | 1 |
| Di Fusco, D | 1 |
| Dinallo, V | 1 |
| Stolfi, C | 1 |
| Di Grazia, A | 1 |
| Marafini, I | 1 |
| Colantoni, A | 1 |
| Ortenzi, A | 1 |
| Alteri, C | 1 |
| Guerrieri, F | 1 |
| Mavilio, M | 1 |
| Ceccherini-Silberstein, F | 1 |
| Federici, M | 1 |
| MacDonald, TT | 1 |
| Monteleone, I | 1 |
| Monteleone, G | 1 |
| Johansson, ME | 5 |
| Gustafsson, JK | 1 |
| Holmén-Larsson, J | 1 |
| Jabbar, KS | 1 |
| Xu, H | 1 |
| Ghishan, FK | 1 |
| Carvalho, FA | 1 |
| Gewirtz, AT | 1 |
| Sjövall, H | 2 |
| Rubin, JE | 1 |
| Costa, MO | 1 |
| Hill, JE | 1 |
| Kittrell, HE | 1 |
| Fernando, C | 1 |
| Huang, Y | 1 |
| O'Connor, B | 1 |
| Harding, JC | 1 |
| Sommer, F | 1 |
| Adam, N | 1 |
| Bäckhed, F | 1 |
| Huang, Z | 1 |
| Wang, Z | 1 |
| Long, S | 1 |
| Jiang, H | 1 |
| Chen, J | 1 |
| Dong, L | 1 |
| Kober, OI | 1 |
| Ahl, D | 2 |
| Pin, C | 1 |
| Holm, L | 4 |
| Carding, SR | 1 |
| Juge, N | 1 |
| Wlodarska, M | 1 |
| Thaiss, CA | 1 |
| Nowarski, R | 1 |
| Henao-Mejia, J | 1 |
| Zhang, JP | 1 |
| Brown, EM | 1 |
| Frankel, G | 1 |
| Levy, M | 1 |
| Katz, MN | 1 |
| Philbrick, WM | 1 |
| Elinav, E | 1 |
| Finlay, BB | 1 |
| Flavell, RA | 1 |
| Bel, S | 1 |
| Elkis, Y | 1 |
| Elifantz, H | 1 |
| Koren, O | 1 |
| Ben-Hamo, R | 1 |
| Lerer-Goldshtein, T | 1 |
| Rahimi, R | 1 |
| Ben Horin, S | 1 |
| Nyska, A | 1 |
| Shpungin, S | 1 |
| Nir, U | 1 |
| Motta, JP | 1 |
| Flannigan, KL | 1 |
| Agbor, TA | 1 |
| Beatty, JK | 1 |
| Blackler, RW | 1 |
| Workentine, ML | 1 |
| Da Silva, GJ | 1 |
| Wang, R | 1 |
| Buret, AG | 1 |
| Wallace, JL | 2 |
| Sanjo, H | 1 |
| Tokumaru, S | 1 |
| Akira, S | 1 |
| Taki, S | 1 |
| Erickson, NA | 1 |
| Nyström, EE | 1 |
| Mundhenk, L | 1 |
| Glauben, R | 1 |
| Heimesaat, MM | 1 |
| Fischer, A | 1 |
| Bereswill, S | 1 |
| Birchenough, GM | 1 |
| Gruber, AD | 1 |
| Sovran, B | 1 |
| Lu, P | 1 |
| Loonen, LM | 1 |
| Hugenholtz, F | 1 |
| Belzer, C | 1 |
| Stolte, EH | 1 |
| Boekschoten, MV | 1 |
| van Baarlen, P | 1 |
| Smidt, H | 1 |
| Kleerebezem, M | 1 |
| de Vos, P | 1 |
| Renes, IB | 1 |
| Wells, JM | 1 |
| Dekker, J | 1 |
| Liu, H | 1 |
| Schreiber, O | 2 |
| Roos, S | 2 |
| Phillipson, M | 3 |
| Scales, BS | 1 |
| Dickson, RP | 1 |
| Huffnagle, GB | 1 |
| De Arcangelis, A | 1 |
| Hamade, H | 1 |
| Alpy, F | 1 |
| Normand, S | 1 |
| Bruyère, E | 1 |
| Lefebvre, O | 1 |
| Méchine-Neuville, A | 1 |
| Siebert, S | 1 |
| Pfister, V | 1 |
| Lepage, P | 1 |
| Laquerriere, P | 1 |
| Dembele, D | 1 |
| Delanoye-Crespin, A | 1 |
| Rodius, S | 1 |
| Robine, S | 1 |
| Kedinger, M | 1 |
| Van Seuningen, I | 2 |
| Simon-Assmann, P | 1 |
| Chamaillard, M | 1 |
| Labouesse, M | 1 |
| Georges-Labouesse, E | 1 |
| Petersson, J | 2 |
| Velcich, A | 1 |
| Park, SW | 1 |
| Zhen, G | 1 |
| Verhaeghe, C | 1 |
| Nakagami, Y | 1 |
| Nguyenvu, LT | 1 |
| Barczak, AJ | 1 |
| Killeen, N | 1 |
| Erle, DJ | 1 |
| Baltar-Arias, R | 1 |
| Ulla-Rocha, JL | 1 |
| Moreno-López, E | 1 |
| Fernández-Salgado, E | 1 |
| Vázquez-Rodríguez, S | 1 |
| Díaz-Saa, W | 1 |
| Carrera-González, V | 1 |
| Vázquez-Astray, E | 1 |
| Dicksved, J | 1 |
| Willing, B | 1 |
| Rang, S | 1 |
| BISHOP, JF | 1 |
| SMITH, FW | 1 |
| ADAMS, JL | 1 |
| SCHEIKEVITCH, V | 1 |
| McCRACKEN, WJ | 1 |
| REINER, L | 1 |
| SCHLESINGER, MJ | 1 |
| MILLER, GM | 1 |
| TIEGEL, W | 1 |
| Swidsinski, A | 1 |
| Loening-Baucke, V | 1 |
| Theissig, F | 1 |
| Engelhardt, H | 1 |
| Bengmark, S | 1 |
| Koch, S | 1 |
| Lochs, H | 1 |
| Dörffel, Y | 1 |
| Laurent, V | 1 |
| Corby, S | 1 |
| Meyer-Bisch, L | 1 |
| Ciprian-Corby, S | 1 |
| Barbary, C | 1 |
| Beot, S | 1 |
| Bresler, L | 1 |
| Régent, D | 1 |
| Krimi, RB | 1 |
| Kotelevets, L | 1 |
| Dubuquoy, L | 1 |
| Plaisancié, P | 1 |
| Walker, F | 1 |
| Lehy, T | 1 |
| Desreumaux, P | 1 |
| Chastre, E | 1 |
| Forgue-Lafitte, ME | 1 |
| Marie, JC | 1 |
| Scheppach, W | 1 |
| Zeeh, JM | 1 |
| Procaccino, F | 1 |
| Hoffmann, P | 1 |
| Aukerman, SL | 1 |
| McRoberts, JA | 1 |
| Soltani, S | 1 |
| Pierce, GF | 1 |
| Lakshmanan, J | 1 |
| Lacey, D | 1 |
| Eysselein, VE | 1 |
| Asfaha, S | 1 |
| MacNaughton, WK | 1 |
| Appleyard, CB | 1 |
| Chadee, K | 1 |
| Jass, JR | 1 |
| Rhodes, JM | 1 |
| Bustos-Fernández, L | 1 |
| González, E | 1 |
| Kofoed, JA | 1 |
| Hamamura, S | 1 |
| Schiffrin, E | 1 |
| Celener, D | 1 |
| Ledesma de Paolo, MI | 1 |
| Ojeda, VJ | 1 |
| Levitt, S | 1 |
| Ryan, G | 1 |
| Laurence, BH | 1 |
| Schein, M | 1 |
| Veller, M | 1 |
| Decker, GA | 1 |
| Shapiro, FM | 1 |
| Shalygina, NB | 1 |
| Swales, JD | 1 |
| Tange, JD | 1 |
| Evans, DJ | 1 |
| Sullivan, JJ | 1 |
| Friend, WD | 1 |
| Lee, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Efficacy and Safety of Rifaximin in Combination With N-acetylcysteine (NAC) in Adult Patients With Irritable Bowel Syndrome With Diarrhea[NCT04557215] | Phase 1/Phase 2 | 45 participants (Actual) | Interventional | 2020-11-13 | Completed | ||
| Use of Novel Human Milk Prebiotics to Improve the Quality of Life for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction[NCT03987126] | Phase 3 | 30 participants (Actual) | Interventional | 2021-01-27 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change in severity of abdominal pain from baseline, as determined from weekly average visual analog scale (VAS) scores, relative to Rifaximin alone. VAS scores allows subject to choose 0 for no pain to 100 pain as bad as it could possibly be.~The Visual Analogue Scale (VAS) measures pain intensity. The VAS consists of a 10cm line, with two end points representing 0 no pain and 100 pain as bad as it could possibly be~The change between two time points is reported baseline and 4 weeks after cessation of treatment (at 6 weeks)" (NCT04557215)
Timeframe: value at 6 weeks minus value at baseline
| Intervention | units on a scale (Mean) |
|---|---|
| Rifaximin 550 mg | -5.43 |
| Rifaximin 200 mg + Placebo | -8.90 |
| Rifaximin 200 mg Plus N-acetylcysteine (NAC) 600 mg Days | -5.59 |
"Change in stool form from baseline, as determined from stool diary data comparing Rifaximin alone vs rifaximin and NAC~The Bristol Stool Chart, the minimum value is 1 (means constipation) and maximum value is 7 (means diarrhea).~The change between two time points is reported baseline and 4 weeks after cessation of treatment (at 6 weeks)" (NCT04557215)
Timeframe: value at 6 weeks minus value at baseline
| Intervention | score on a scale (Mean) |
|---|---|
| Rifaximin 550 mg | -0.26 |
| Rifaximin 200 mg + Placebo | -0.45 |
| Rifaximin 200 mg Plus N-acetylcysteine (NAC) 600 mg Days | -0.49 |
"Change in stool frequency from baseline, as determined from diary data comparing Rifaximin alone vs Rifaximin and NAC~determined from daily stool diary data~The change in bowel movements/day between two time points is reported baseline and 4 weeks after cessation of treatment (at 6 weeks)" (NCT04557215)
Timeframe: value at 6 weeks minus value at baseline
| Intervention | number of bowel movements (Mean) |
|---|---|
| Rifaximin 550 mg | -0.04 |
| Rifaximin 200 mg + Placebo | -0.50 |
| Rifaximin 200 mg Plus N-acetylcysteine (NAC) 600 mg Days | -0.24 |
3 reviews available for guaifenesin and Colitis
| Article | Year |
|---|---|
The gastrointestinal mucus system in health and disease.
Topics: Colitis; Colon; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; Intestine, Small; Mucus; | 2013 |
A tale of two sites: how inflammation can reshape the microbiomes of the gut and lungs.
Topics: Anaerobiosis; Colitis; Cystic Fibrosis; Escherichia coli Infections; Feedback, Physiological; Gammap | 2016 |
Colonic mucus and mucosal glycoproteins: the key to colitis and cancer?
Topics: Colitis; Colon; Colonic Neoplasms; Glycoproteins; Humans; Intestinal Mucosa; Mucus | 1989 |
64 other studies available for guaifenesin and Colitis
| Article | Year |
|---|---|
Dietary xylo-oligosaccharide ameliorates colonic mucus microbiota penetration with restored autophagy in interleukin-10 gene-deficient mice.
Topics: Animals; Autophagy; Colitis; Inflammatory Bowel Diseases; Interleukin-10; Male; Mice; Microbiota; Mu | 2022 |
Altered Mucus Barrier Integrity and Increased Susceptibility to Colitis in Mice upon Loss of Telocyte Bone Morphogenetic Protein Signalling.
Topics: Animals; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Colitis; Colon; | 2021 |
Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer.
Topics: Animals; Colitis; Colon; Mice; Mucin-2; Mucus; Transglutaminases | 2022 |
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Docosahexaeno | 2022 |
Maltodextrin Consumption Impairs the Intestinal Mucus Barrier and Accelerates Colitis Through Direct Actions on the Epithelium.
Topics: Animals; Colitis; Diet, Western; Epithelium; Food Additives; Humans; Mice; Mucus; Polysaccharides | 2022 |
Phytoestrogen arctigenin preserves the mucus barrier in inflammatory bowel diseases by inhibiting goblet cell apoptosis via the ERβ/TRIM21/PHB1 pathway.
Topics: Animals; Apoptosis; Colitis; Estrogen Receptor beta; Furans; Goblet Cells; Inflammatory Bowel Diseas | 2022 |
Milk Fat Globule Membrane Attenuates Acute Colitis and Secondary Liver Injury by Improving the Mucus Barrier and Regulating the Gut Microbiota.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Glycolipids; | 2022 |
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection.
Topics: Animals; Calcitonin Gene-Related Peptide; Colitis; Goblet Cells; Humans; Mice; Mucus; Nociceptors; R | 2022 |
An Elemental Diet Enriched in Amino Acids Alters the Gut Microbial Community and Prevents Colonic Mucus Degradation in Mice with Colitis.
Topics: Amino Acids; Animals; Bacteria; Colitis; Expectorants; Humans; Mice; Microbiota; Mucus | 2022 |
An Elemental Diet Enriched in Amino Acids Alters the Gut Microbial Community and Prevents Colonic Mucus Degradation in Mice with Colitis.
Topics: Amino Acids; Animals; Bacteria; Colitis; Expectorants; Humans; Mice; Microbiota; Mucus | 2022 |
An Elemental Diet Enriched in Amino Acids Alters the Gut Microbial Community and Prevents Colonic Mucus Degradation in Mice with Colitis.
Topics: Amino Acids; Animals; Bacteria; Colitis; Expectorants; Humans; Mice; Microbiota; Mucus | 2022 |
An Elemental Diet Enriched in Amino Acids Alters the Gut Microbial Community and Prevents Colonic Mucus Degradation in Mice with Colitis.
Topics: Amino Acids; Animals; Bacteria; Colitis; Expectorants; Humans; Mice; Microbiota; Mucus | 2022 |
Modified Gegen Qinlian decoction ameliorates DSS-induced chronic colitis in mice by restoring the intestinal mucus barrier and inhibiting the activation of γδT17 cells.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Inflammasomes | 2023 |
Shaoyao decoction restores the mucus layer in mice with DSS-induced colitis by regulating Notch signaling pathway.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Drugs, Chines | 2023 |
Rosmarinic Acid Restores Colonic Mucus Secretion in Colitis Mice by Regulating Gut Microbiota-Derived Metabolites and the Activation of Inflammasomes.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Inflammasome | 2023 |
Stressing out over mucus secretion.
Topics: Animals; Colitis; Goblet Cells; Intestinal Mucosa; Mice; Mucus | 2023 |
Autotaxin promotes the degradation of the mucus layer by inhibiting autophagy in mouse colitis.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Colitis; Inflammation; Mice; Mucus | 2023 |
Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects.
Topics: Animals; Anti-Bacterial Agents; Colitis; Colon; Cytochrome b Group; Disease Models, Animal; Dysbiosi | 2019 |
Novel Human NKCC1 Mutations Cause Defects in Goblet Cell Mucus Secretion and Chronic Inflammation.
Topics: Animals; Chronic Disease; Citrobacter rodentium; Colectomy; Colitis; Colon; Disease Models, Animal; | 2020 |
TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity.
Topics: Animals; Carcinogenesis; Carrier Proteins; Colitis; Colitis-Associated Neoplasms; Colon; Goblet Cell | 2021 |
Elevated miR-124-3p in the aging colon disrupts mucus barrier and increases susceptibility to colitis by targeting T-synthase.
Topics: Age Factors; Colitis; Colon; Female; Galactosyltransferases; Humans; Intestinal Mucosa; Male; MicroR | 2020 |
The expression of P2Y
Topics: Animals; Colitis; Dextran Sulfate; Gene Expression Regulation; Goblet Cells; Humans; Inflammatory Bo | 2021 |
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function.
Topics: Animals; Cell Differentiation; Colitis; Colitis, Ulcerative; Colon; Goblet Cells; Humans; Intestinal | 2021 |
Casein-fed mice showed faster recovery from DSS-induced colitis than chicken-protein-fed mice.
Topics: Animals; Bacteria; Body Weight; Caseins; Chickens; Colitis; Colon; Dextran Sulfate; Disease Models, | 2021 |
Increased mucin-degrading bacteria by high protein diet leads to thinner mucus layer and aggravates experimental colitis.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Caseins; Colitis; Colon; Dextran Sulfate; Diet, High-Prote | 2021 |
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion.
Topics: Animals; Autophagy; Colitis; Dysbiosis; Fatty Acids, Volatile; Female; Forkhead Box Protein O1; Gast | 2021 |
Compositional Changes in the Gut Mucus Microbiota Precede the Onset of Colitis-Induced Inflammation.
Topics: Animals; Bacteria; Colitis; Colon; Disease Models, Animal; DNA, Bacterial; Dysbiosis; Feces; Gastroi | 2017 |
Peroxisome proliferator-activated receptor gamma activation promotes intestinal barrier function by improving mucus and tight junctions in a mouse colitis model.
Topics: Animals; Caco-2 Cells; Colitis; Dextran Sulfate; Disease Models, Animal; HT29 Cells; Humans; Intesti | 2018 |
Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis.
Topics: Animals; Animals, Outbred Strains; Citrobacter rodentium; Colitis; Colon; Dibenzazepines; Disease Mo | 2018 |
The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation.
Topics: Animals; Cattle; Colitis; Diet; Disease Progression; Endoplasmic Reticulum Stress; Epithelial Cells; | 2019 |
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis.
Topics: Adolescent; Adult; Aged; Animals; Colitis; Colitis, Ulcerative; Colon; Female; Humans; In Situ Hybri | 2014 |
Reproduction of mucohaemorrhagic diarrhea and colitis indistinguishable from swine dysentery following experimental inoculation with "Brachyspira hampsonii" strain 30446.
Topics: Animal Husbandry; Animals; Brachyspira; Colitis; Colon; Diarrhea; Feces; Gastrointestinal Hemorrhage | 2013 |
Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture.
Topics: Animals; Bacteria; Colitis; Dextran Sulfate; Female; Galactosemias; Glycosylation; Intestinal Mucosa | 2014 |
A 3-D artificial colon tissue mimic for the evaluation of nanoparticle-based drug delivery system.
Topics: Animals; Biomimetics; Caco-2 Cells; Colitis; Colon; Cytokines; Drug Delivery Systems; Drug Evaluatio | 2014 |
γδ T-cell-deficient mice show alterations in mucin expression, glycosylation, and goblet cells but maintain an intact mucus layer.
Topics: Animals; Antigens, Surface; Colitis; Dextran Sulfate; Disease Models, Animal; Epidermal Growth Facto | 2014 |
NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.
Topics: Animals; Autophagy; Colitis; Colon; Epithelial Cells; Goblet Cells; Inflammasomes; Intestinal Mucosa | 2014 |
Reprogrammed and transmissible intestinal microbiota confer diminished susceptibility to induced colitis in TMF-/- mice.
Topics: Animals; Cell Shape; Colitis; Colon; Disease Susceptibility; DNA-Binding Proteins; Feces; Golgi Matr | 2014 |
Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production.
Topics: Animals; Biofilms; Colitis; Dextran Sulfate; Gasotransmitters; Gastrointestinal Microbiome; Humans; | 2015 |
Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCRαβ+ Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis.
Topics: Animals; Antimicrobial Cationic Peptides; Colitis; Cytokines; Disease Models, Animal; Intestinal Muc | 2015 |
The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice.
Topics: Animals; Chloride Channels; Colitis; Colon; Dextran Sulfate; Feces; Gene Expression; Mice, Inbred C5 | 2015 |
Identification of Commensal Species Positively Correlated with Early Stress Responses to a Compromised Mucus Barrier.
Topics: Animals; Colitis; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Intestinal | 2016 |
Lactobacillus reuteri increases mucus thickness and ameliorates dextran sulphate sodium-induced colitis in mice.
Topics: Animals; Colitis; Colon; Cytokines; Dextran Sulfate; Limosilactobacillus reuteri; Male; Mice; Mice, | 2016 |
Hemidesmosome integrity protects the colon against colitis and colorectal cancer.
Topics: Adaptive Immunity; Adenocarcinoma; Animals; B-Lymphocytes; Basement Membrane; Caspase 1; Colitis; Co | 2017 |
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.
Topics: Animals; Colitis; Colon; Intestinal Mucosa; Mice; Mice, Mutant Strains; Mucin-2; Mucins; Mucus; Rats | 2008 |
The protein disulfide isomerase AGR2 is essential for production of intestinal mucus.
Topics: Acute Disease; Animals; Cell Lineage; Colitis; Disulfides; Endoplasmic Reticulum; Epithelial Cells; | 2009 |
Rectal polyp as presentation form of colitis cystica profunda.
Topics: Colitis; Colonoscopy; Cysts; Female; Gastrointestinal Hemorrhage; Humans; Intestinal Polyps; Middle | 2010 |
Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction.
Topics: Animals; Bacterial Load; Bacterial Translocation; Colitis; Colon; Dextran Sulfate; Intestinal Mucosa | 2012 |
Irritable colon: symptom or clinical entity?
Topics: Colitis; Humans; Irritable Bowel Syndrome; Mucus | 1953 |
Surgical significance of spastic colon.
Topics: Colitis; Humans; Irritable Bowel Syndrome; Mucus; Muscle Spasticity | 1959 |
THE COLON PATTERNS IN ANXIETY AND INTROSPECTION.
Topics: Anxiety; Colitis; Colonic Diseases; Colonic Diseases, Functional; Constipation; Defecation; Diarrhea | 1964 |
[Etiologic role of sequelae of infectious, parasitic or irritative colitis in the production of certain chronic constipations; functional importance of the intestinal mucus].
Topics: Colitis; Constipation; Humans; Intestines; Mucus; Parasitic Diseases | 1951 |
Non-specific mucus colitis following the use of terramycin and aureomycin.
Topics: Chlortetracycline; Colitis; Irritable Bowel Syndrome; Mucus; Oxytetracycline | 1952 |
Pseudomembranous colitis following aureomycin and chloramphenicol.
Topics: Chloramphenicol; Chlortetracycline; Colitis; Drug-Related Side Effects and Adverse Reactions; Entero | 1952 |
[Mucous catarrh of the colon in children].
Topics: Child; Colitis; Common Cold; Humans; Intestines; Mucus | 1950 |
Comparative study of the intestinal mucus barrier in normal and inflamed colon.
Topics: Acute Disease; Adult; Appendicitis; Appendix; Bacteria; Bacterial Translocation; Biopsy; Colitis; Co | 2007 |
[MRI aspect of rare rectal pseudotumor associated with dyschezia: colitis cystica profunda].
Topics: Aged; Colitis; Constipation; Contrast Media; Cysts; Humans; Image Enhancement; Intestinal Mucosa; Ma | 2007 |
Resistin-like molecule beta regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice.
Topics: Animals; Blotting, Western; Calcium; Carbachol; Cells, Cultured; Colitis; Gastrins; Gene Expression; | 2008 |
Effects of short chain fatty acids on gut morphology and function.
Topics: Cell Differentiation; Colitis; Colon; Enteral Nutrition; Fatty Acids, Volatile; Gastrointestinal Mot | 1994 |
Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats.
Topics: Animals; Cell Division; Colitis; Disease Models, Animal; Fibroblast Growth Factor 10; Fibroblast Gro | 1996 |
Persistent epithelial dysfunction and bacterial translocation after resolution of intestinal inflammation.
Topics: 1-Methyl-3-isobutylxanthine; Acute Disease; Animals; Bacteria, Aerobic; Bacterial Toxins; Bacterial | 2001 |
Colonic mucus and colitis.
Topics: Colitis; Humans; Mucins; Mucus; Sialomucins | 1990 |
Pirenzepine as anti-inflammatory drug in a model of experimental colitis in rat.
Topics: Acetates; Acetic Acid; Animals; Colitis; Colon; Colonic Diseases; Edema; Male; Mucus; Pirenzepine; R | 1987 |
Cystic fibrosis, Crohn's colitis, and adult meconium ileus equivalent.
Topics: Adult; Colectomy; Colitis; Crohn Disease; Cystic Fibrosis; Gastrointestinal Hemorrhage; Humans; Inte | 1986 |
Colitis cystica profunda simulating rectal carcinoma. A case report.
Topics: Adult; Colitis; Cysts; Diagnosis, Differential; Female; Humans; Mucus; Rectal Diseases; Rectal Neopl | 1987 |
[Morphological changes in the gastric mucosa in patients with chronic enterocolitis (according to aspiration biopsy data)].
Topics: Adolescent; Adult; Biopsy; Chronic Disease; Colitis; DNA; Gastric Mucosa; Glycosaminoglycans; Histoc | 1968 |
Intestinal ammonia in uraemia: the effect of a urease inhibitor, acetohydroxamic acid.
Topics: Ammonia; Animals; Blood Proteins; Cecum; Colitis; Colon; Edema; Erythrocytes; Hydroxamic Acids; Infl | 1972 |
Localized submucosal mucous cysts of the rectum (colitis cystica profunda).
Topics: Adult; Colitis; Cysts; Humans; Intestinal Mucosa; Male; Mucus; Rectal Diseases | 1968 |