guaifenesin has been researched along with Chronic Bronchitis in 29 studies
Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ninety-eight patients with chronic obstructive pulmonary disease and/or chronic bronchitis (n=78), or bronchiectasis (n=20), with a peak cough expiratory flow >150 l/min and sputum production >30 ml/day, randomly included into two treatment groups." | 2.78 | Efficacy of temporary positive expiratory pressure (TPEP) in patients with lung diseases and chronic mucus hypersecretion. The UNIKO® project: a multicentre randomized controlled trial. ( Ambrosino, N; Balbi, B; Berrighi, D; Bianchi, L; Cavicchioli, PP; Clini, EM; Crisafulli, E; Dabrosca, F; DeBiase, A; Galimberti, V; Iattoni, A; Paneroni, M; Righi, D; Schiavoni, G; Vagheggini, G; Venturelli, E; Vitacca, M; Zaurino, M, 2013) |
| "Mucus accumulation in COPD patients affects several important outcomes such as lung function, health-related quality of life, COPD exacerbations, hospitalizations, and mortality." | 2.50 | Clinical issues of mucus accumulation in COPD. ( Kim, V; Krahnke, JS; Ramos, FL, 2014) |
| "We explored whether the COPD Assessment Test (CAT), a simple measure developed for routine clinical use, captures CMH populations and outcomes similarly to MRC and St." | 1.56 | Defining Chronic Mucus Hypersecretion Using the CAT in the SPIROMICS Cohort. ( Anderson, W; Comellas, AP; Cooper, CB; Dransfield, M; Drummond, MB; El Baou, C; Han, M; Hansel, NN; Kanner, RE; Keeley, T; Kim, V; Lazaar, AL; Martinez, FJ; Miller, B; Müllerová, H; Ortega, VE; Paine Iii, R; Stott-Miller, M; Tabberer, M; Tal-Singer, R; Woodruff, P, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (13.79) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (34.48) | 29.6817 |
| 2010's | 11 (37.93) | 24.3611 |
| 2020's | 4 (13.79) | 2.80 |
| Authors | Studies |
|---|---|
| Yakoot, M | 1 |
| Salem, A | 1 |
| Omar, AM | 1 |
| WEINER, A | 1 |
| HEISEN, A | 1 |
| Krimsky, W | 1 |
| Neal Ii, RE | 1 |
| Kim, V | 5 |
| Stott-Miller, M | 1 |
| Müllerová, H | 1 |
| Miller, B | 1 |
| Tabberer, M | 1 |
| El Baou, C | 1 |
| Keeley, T | 1 |
| Martinez, FJ | 1 |
| Han, M | 1 |
| Dransfield, M | 1 |
| Hansel, NN | 1 |
| Cooper, CB | 1 |
| Woodruff, P | 1 |
| Ortega, VE | 1 |
| Comellas, AP | 1 |
| Paine Iii, R | 1 |
| Kanner, RE | 1 |
| Anderson, W | 1 |
| Drummond, MB | 1 |
| Tal-Singer, R | 1 |
| Lazaar, AL | 1 |
| Dolliver, WR | 1 |
| Nath, HP | 1 |
| Grumley, SA | 1 |
| Terry, N | 1 |
| Ahmed, A | 1 |
| Yen, A | 1 |
| Jacobs, K | 1 |
| Kligerman, S | 1 |
| Diaz, AA | 1 |
| Andelid, K | 1 |
| Öst, K | 1 |
| Andersson, A | 1 |
| Mohamed, E | 1 |
| Jevnikar, Z | 1 |
| Vanfleteren, LEGW | 1 |
| Göransson, M | 1 |
| Henderson, AG | 3 |
| Anderson, WH | 3 |
| Ceppe, A | 1 |
| Coakley, RD | 2 |
| Button, B | 3 |
| Alexis, NE | 2 |
| Peden, DB | 2 |
| Lazarowski, ER | 2 |
| Davis, CW | 2 |
| Fuller, F | 2 |
| Almond, M | 2 |
| Qaqish, B | 2 |
| Kesimer, M | 2 |
| Boucher, RC | 3 |
| Ramos, FL | 1 |
| Krahnke, JS | 1 |
| Osadnik, CR | 1 |
| McDonald, CF | 1 |
| Holland, AE | 1 |
| Zeman, KL | 1 |
| Bailey, S | 1 |
| Bordonali, E | 1 |
| Rubinstein, M | 1 |
| Bennett, WD | 2 |
| Baraniuk, JN | 1 |
| Casado, B | 1 |
| Pannell, LK | 1 |
| McGarvey, PB | 1 |
| Boschetto, P | 1 |
| Luisetti, M | 1 |
| Iadarola, P | 1 |
| Donaldson, SH | 1 |
| Iwasawa, S | 1 |
| Kikuchi, Y | 1 |
| Nishiwaki, Y | 1 |
| Nakano, M | 1 |
| Michikawa, T | 1 |
| Tsuboi, T | 1 |
| Tanaka, S | 1 |
| Uemura, T | 1 |
| Ishigami, A | 1 |
| Nakashima, H | 1 |
| Takebayashi, T | 1 |
| Adachi, M | 1 |
| Morikawa, A | 1 |
| Maruyama, K | 1 |
| Kudo, S | 1 |
| Uchiyama, I | 1 |
| Omae, K | 1 |
| Voynow, JA | 1 |
| Rubin, BK | 1 |
| Braman, SS | 1 |
| Abu-Hijleh, M | 1 |
| Venturelli, E | 1 |
| Crisafulli, E | 1 |
| DeBiase, A | 1 |
| Righi, D | 1 |
| Berrighi, D | 1 |
| Cavicchioli, PP | 1 |
| Vagheggini, G | 1 |
| Dabrosca, F | 1 |
| Balbi, B | 1 |
| Paneroni, M | 1 |
| Bianchi, L | 1 |
| Vitacca, M | 1 |
| Galimberti, V | 1 |
| Zaurino, M | 1 |
| Schiavoni, G | 1 |
| Iattoni, A | 1 |
| Ambrosino, N | 1 |
| Clini, EM | 1 |
| Criner, GJ | 1 |
| Evrensel, CA | 1 |
| Khan, MR | 1 |
| KOCHETKOV, NK | 1 |
| ZHUKOVA, IG | 1 |
| GLUKHODED, IS | 1 |
| REID, L | 1 |
| Springer, J | 1 |
| Groneberg, DA | 1 |
| Pregla, R | 1 |
| Fischer, A | 1 |
| O'Hara, J | 1 |
| Jones, NS | 1 |
| Vestbo, J | 1 |
| Rogers, DF | 1 |
| Barnes, PJ | 1 |
| Kadota, J | 1 |
| Zhu, J | 2 |
| Qiu, Y | 2 |
| Valobra, M | 1 |
| Qiu, S | 1 |
| Majumdar, S | 2 |
| Matin, D | 1 |
| De Rose, V | 2 |
| Jeffery, PK | 2 |
| Ansari, T | 1 |
| Oliva, A | 1 |
| Kips, JC | 1 |
| Pauwels, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Subpopulations and Intermediate Outcome Measures in COPD Study[NCT01969344] | 2,981 participants (Actual) | Observational | 2010-11-30 | Active, not recruiting | |||
| Comparison of Resistive Breathing Versus Inspiratory Hold Technique in Patients With Chronic Bronchitis[NCT05533931] | 26 participants (Anticipated) | Interventional | 2022-09-30 | Not yet recruiting | |||
| Comparative Effects of Costophrenic Assisted Cough and Anterior Chest Compression Technique on Sputum Diary, Oxygen Saturation, Expiratory Flow Rate, and Dyspnea in Patients With Chronic Obstructive Pulmonary Disease[NCT05922241] | 34 participants (Actual) | Interventional | 2023-06-15 | Completed | |||
| A Prospective Safety and Feasibility Study of the RejuvenAir™ System Metered Cryospray Therapy for Chronic Bronchitis Patients[NCT02483637] | 30 participants (Actual) | Interventional | 2016-02-29 | Completed | |||
| Comparative Effects of Anterior Chest Compression Assist and Abdominal Thrust Assist Technique on Sputum Diary, Oxygen Saturation, Expiratory Flow Rate, and Dyspnea in Patients With Chronic Obstructive Pulmonary Disease[NCT05936801] | 34 participants (Anticipated) | Interventional | 2023-07-15 | Not yet recruiting | |||
| Effects of Positive Expiratory Pressure Breathing Versus Incentive Spirometry on Dyspnea and Sputum Profile in Bronchiolectasis Patients[NCT05719597] | 24 participants (Actual) | Interventional | 2022-06-01 | Completed | |||
| Comparison Of Blow Bottle Positive Expiratory Pressure (BBPEP) Versus Acapella on Oxygenation ,Peak Expiratory Flow Rate (PEFR) Among Patient With Chronic Bronchitis[NCT06086730] | 36 participants (Actual) | Interventional | 2023-07-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for guaifenesin and Chronic Bronchitis
| Article | Year |
|---|---|
Airway Mucosal Remodeling: Mechanism of Action and Preclinical Data of Pulsed Electric Fields for Chronic Bronchitis and Mucus Hypersecretion.
Topics: Animals; Bronchitis, Chronic; Goblet Cells; Humans; Inflammation; Mucous Membrane; Mucus; Quality of | 2023 |
Clinical issues of mucus accumulation in COPD.
Topics: Anti-Bacterial Agents; Bronchitis, Chronic; Expectorants; Goblet Cells; Humans; Lung; Mucociliary Cl | 2014 |
Clinical issues of mucus accumulation in COPD.
Topics: Anti-Bacterial Agents; Bronchitis, Chronic; Expectorants; Goblet Cells; Humans; Lung; Mucociliary Cl | 2014 |
Clinical issues of mucus accumulation in COPD.
Topics: Anti-Bacterial Agents; Bronchitis, Chronic; Expectorants; Goblet Cells; Humans; Lung; Mucociliary Cl | 2014 |
Clinical issues of mucus accumulation in COPD.
Topics: Anti-Bacterial Agents; Bronchitis, Chronic; Expectorants; Goblet Cells; Humans; Lung; Mucociliary Cl | 2014 |
Clinical issues of mucus accumulation in COPD.
Topics: Anti-Bacterial Agents; Bronchitis, Chronic; Expectorants; Goblet Cells; Humans; Lung; Mucociliary Cl | 2014 |
Clinical issues of mucus accumulation in COPD.
Topics: Anti-Bacterial Agents; Bronchitis, Chronic; Expectorants; Goblet Cells; Humans; Lung; Mucociliary Cl | 2014 |
Clinical issues of mucus accumulation in COPD.
Topics: Anti-Bacterial Agents; Bronchitis, Chronic; Expectorants; Goblet Cells; Humans; Lung; Mucociliary Cl | 2014 |
Clinical issues of mucus accumulation in COPD.
Topics: Anti-Bacterial Agents; Bronchitis, Chronic; Expectorants; Goblet Cells; Humans; Lung; Mucociliary Cl | 2014 |
Clinical issues of mucus accumulation in COPD.
Topics: Anti-Bacterial Agents; Bronchitis, Chronic; Expectorants; Goblet Cells; Humans; Lung; Mucociliary Cl | 2014 |
Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype.
Topics: Bronchitis, Chronic; Cilia; Cystic Fibrosis; Epithelial Cells; Humans; Mucociliary Clearance; Mucus; | 2016 |
Hydrator Therapies for Chronic Bronchitis. Lessons from Cystic Fibrosis.
Topics: Administration, Inhalation; Bronchitis, Chronic; Cystic Fibrosis; Diuretics, Osmotic; Epithelial Sod | 2016 |
Mucins, mucus, and sputum.
Topics: Asthma; Bronchitis, Chronic; Cystic Fibrosis; Female; Humans; Male; Mucins; Mucociliary Clearance; M | 2009 |
Chronic bronchitis and chronic obstructive pulmonary disease.
Topics: Adrenergic beta-Agonists; Anti-Bacterial Agents; Antioxidants; Bronchitis, Chronic; Cholinergic Anta | 2013 |
CHRONIC BRONCHITIS AND EMPHYSEMA.
Topics: Bronchitis; Bronchitis, Chronic; Classification; Emphysema; Humans; Mucus; Pathology; Pneumoconiosis | 1964 |
The aetiology of chronic cough: a review of current theories for the otorhinolaryngologist.
Topics: Angiotensin-Converting Enzyme Inhibitors; Asthma; Bronchitis, Chronic; Chronic Disease; Cough; Eosin | 2005 |
Chronic mucus hypersecretion, exacerbations and natural history of COPD.
Topics: Bronchitis, Chronic; Forced Expiratory Volume; Humans; Mucus; Pulmonary Disease, Chronic Obstructive | 2005 |
Treatment of airway mucus hypersecretion.
Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchitis, Chronic; Drug Design; Goblet Ce | 2006 |
[Pathophysiology of chronic airway infections].
Topics: Anti-Bacterial Agents; Body Water; Bronchiectasis; Bronchiolitis; Bronchitis, Chronic; Cystic Fibros | 2006 |
2 trials available for guaifenesin and Chronic Bronchitis
| Article | Year |
|---|---|
Clinical efficacy of farcosolvin syrup (ambroxol-theophylline-guaiphenesin mixture) in the treatment of acute exacerbation of chronic bronchitis.
Topics: Aged; Ambroxol; Bronchitis, Chronic; Bronchodilator Agents; Cough; Drug Combinations; Egypt; Expecto | 2010 |
Efficacy of temporary positive expiratory pressure (TPEP) in patients with lung diseases and chronic mucus hypersecretion. The UNIKO® project: a multicentre randomized controlled trial.
Topics: Aged; Analysis of Variance; Bronchitis; Bronchitis, Chronic; Female; Humans; Inspiratory Capacity; I | 2013 |
16 other studies available for guaifenesin and Chronic Bronchitis
| Article | Year |
|---|---|
CLINICAL EFFECTIVENESS OF OXTRIPHYLLINE-GLYCERYL GUAIACOLATE COMBINATION IN CHRONIC BRONCHITIS: DOUBLE-BLIND STUDY.
Topics: Bronchitis; Bronchitis, Chronic; Choline; Double-Blind Method; Guaifenesin; Humans; Theophylline; Tr | 1963 |
OXTRIPHYLLINE-GLYCERYL GUAIACOLATE ELIXIR AS EFFECTIVE THERAPY FOR CHRONIC BRONCHITIS AND ASTHMA.
Topics: Adolescent; Asthma; Bronchitis; Bronchitis, Chronic; Child; Choline; Geriatrics; Guaifenesin; Humans | 1964 |
Defining Chronic Mucus Hypersecretion Using the CAT in the SPIROMICS Cohort.
Topics: Bronchitis, Chronic; Female; Humans; Male; Mucus; Pulmonary Disease, Chronic Obstructive; Quality of | 2020 |
Mucus plugging on computed tomography and chronic bronchitis in chronic obstructive pulmonary disease.
Topics: Bronchitis; Bronchitis, Chronic; Humans; Mucus; Pulmonary Disease, Chronic Obstructive; Tomography | 2021 |
Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis.
Topics: Aged; Biomarkers; Bronchitis, Chronic; Disease Progression; Drug Resistance; Female; Follow-Up Studi | 2021 |
Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum.
Topics: Aged; Bronchitis, Chronic; Cell Count; Cytokines; Female; Forced Expiratory Volume; Humans; Male; Mi | 2018 |
Clinical issues of mucus accumulation in COPD.
Topics: Bronchitis, Chronic; Goblet Cells; Humans; Lung; Mucociliary Clearance; Mucus; Pulmonary Disease, Ch | 2014 |
The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis.
Topics: Adult; Aged; Bronchitis, Chronic; Female; Humans; Male; Middle Aged; Mucociliary Clearance; Mucus; O | 2015 |
Protein networks in induced sputum from smokers and COPD patients.
Topics: Adult; Aged; Bronchitis, Chronic; Female; Forced Expiratory Volume; Humans; Immunoglobulin A, Secret | 2015 |
Effects of SO2 on respiratory system of adult Miyakejima resident 2 years after returning to the island.
Topics: Adult; Aged; Aged, 80 and over; Bronchitis, Chronic; Cough; Environmental Exposure; Female; Geograph | 2009 |
The spectrum of nonasthmatic inflammatory airway diseases in adults.
Topics: Adrenal Cortex Hormones; Adult; Bronchial Diseases; Bronchiectasis; Bronchiolitis; Bronchitis, Chron | 2010 |
Interaction of laminar airflow with viscoelastic airway mucus.
Topics: Air; Algorithms; Bronchitis, Chronic; Elasticity; Humans; Models, Biological; Mucociliary Clearance; | 2003 |
MUCUS IN CHRONIC BRONCHITIS.
Topics: Bronchitis, Chronic; Humans; Mucus | 1964 |
Inflammatory cells as source of tachykinin-induced mucus secretion in chronic bronchitis.
Topics: Bronchitis, Chronic; Humans; Immunohistochemistry; Mucus; Pneumonia; Protein Precursors; Receptors, | 2005 |
Plasma cells and IL-4 in chronic bronchitis and chronic obstructive pulmonary disease.
Topics: Aged; Aged, 80 and over; Biomarkers; Bronchi; Bronchitis, Chronic; Disease Progression; Fluorescent | 2007 |
Interleukin-4 and interleukin-5 gene expression and inflammation in the mucus-secreting glands and subepithelial tissue of smokers with chronic bronchitis. Lack of relationship with CD8(+) cells.
Topics: Aged; Aged, 80 and over; Bronchi; Bronchitis, Chronic; CD8-Positive T-Lymphocytes; Epithelium; Exocr | 2001 |