guaifenesin has been researched along with Bronchiectasis in 121 studies
Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
Bronchiectasis: Persistent abnormal dilatation of the bronchi.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this study was to test the effectiveness of oral erdosteine in treating elderly patients with bronchiectasis and chronic mucus hypersecretion who have been referred to a pulmonary rehabilitation program." | 9.12 | Effectiveness of erdosteine in elderly patients with bronchiectasis and hypersecretion: a 15-day, prospective, parallel, open-label, pilot study. ( Bertini, M; Clini, EM; Coletti, O; Costi, S; Crisafulli, E; Fabbri, LM; Lorenzi, C; Lucic, S; Zanasi, E, 2007) |
| "Bronchiectasis is characterised by hypersecretion and impaired clearance of mucus." | 6.73 | Effect of increasing doses of mannitol on mucus clearance in patients with bronchiectasis. ( Anderson, SD; Daviskas, E; Eberl, S; Young, IH, 2008) |
| "The objective of this study was to test the effectiveness of oral erdosteine in treating elderly patients with bronchiectasis and chronic mucus hypersecretion who have been referred to a pulmonary rehabilitation program." | 5.12 | Effectiveness of erdosteine in elderly patients with bronchiectasis and hypersecretion: a 15-day, prospective, parallel, open-label, pilot study. ( Bertini, M; Clini, EM; Coletti, O; Costi, S; Crisafulli, E; Fabbri, LM; Lorenzi, C; Lucic, S; Zanasi, E, 2007) |
| " This problem has been examined by standardizing the macromolecule concentration of sputum from 13 patients suffering from cystic fibrosis, chronic bronchitis or bronchiectasis and adding amikacin to the sputum components." | 3.68 | The binding of amikacin to macromolecules from the sputum of patients suffering from respiratory diseases. ( Bataillon, V; Lafitte, JJ; Lhermitte, M; Pommery, J; Roussel, P, 1992) |
| "Nasal mucociliary clearance was measured using a saccharin technique in 172 patients with perennial rhinitis (76 also had asthma) and in 121 patients with chronic infected rhinosinusitis (40 had asthma, 35 had bronchiectasis)." | 3.67 | Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease. ( Cole, PJ; Greenstone, MA; Mackay, IS; Stanley, PJ; Wilson, R, 1985) |
| "Bronchiectasis is characterized by pathological and irreversible bronchial dilatation caused by the inefficient mucus and microorganism clearance and progression of inflammatory processes." | 2.87 | Effects of exercise on secretion transport, inflammation, and quality of life in patients with noncystic fibrosis bronchiectasis: Protocol for a randomized controlled trial. ( Baddini-Martinez, JA; de Souza, HCD; Dos Santos, DO; Gastaldi, AC; Ramos, EMC, 2018) |
| "Bronchiectasis is characterized by abnormal and permanent dilation of the bronchi, caused by the perpetuation of inflammation and impairment of mucociliary clearance." | 2.84 | Effects of an Airway Clearance Device on Inflammation, Bacteriology, and Mucus Transport in Bronchiectasis. ( Baddini-Martinez, JA; Barnes, PJ; de Souza, HCD; Gastaldi, AC; Martinez, R; Tambascio, J, 2017) |
| "Bronchiectasis is characterised by hypersecretion and impaired clearance of mucus." | 2.73 | Effect of increasing doses of mannitol on mucus clearance in patients with bronchiectasis. ( Anderson, SD; Daviskas, E; Eberl, S; Young, IH, 2008) |
| "The term phenotype in the field of COPD is defined as "a single or combination of disease attributes that describe differences between individuals with COPD as they relate to clinically meaningful outcomes"." | 2.48 | Clinical phenotypes of COPD: identification, definition and implications for guidelines. ( Calle, M; Miravitlles, M; Soler-Cataluña, JJ, 2012) |
| "Firstly, primary ciliary dyskinesia (PCD), a rare genetic deficiency of the ultrastructural apparatus required to propel the cilium, in which nasal nitric oxide is very low due to a deficiency of inducible nitric oxide synthase." | 2.41 | Pathophysiology and treatment of airway mucociliary clearance. A moving tale. ( Cole, P, 2001) |
| "Chronic bronchitis is characterized by mucus hypersecretion." | 2.37 | The pathology of obstructive and inflammatory airway diseases. ( Reid, LM, 1986) |
| "Bronchiectasis is a complex, heterogeneous disorder defined by both a radiological abnormality of permanent bronchial dilatation and a clinical syndrome." | 1.62 | Pathophysiology of Bronchiectasis. ( Chalmers, JD; Keir, HR, 2021) |
| "The characteristics of Allergic Bronchopulmonary Aspergillosis (ABPA) based on its radiological classification is still unclear." | 1.56 | The clinical characteristics and prognosis of ABPA are closely related to the mucus plugs in central bronchiectasis. ( Bai, JW; Cao, WJ; Cheng, KB; Gu, SY; Ji, XB; Jia, XM; Jiang, S; Li, CW; Liang, S; Lu, HW; Mao, B; Wang, H; Wei, P; Xu, JF; Yang, JW, 2020) |
| "20 prospectively enrolled COPD patients (GOLD I-IV) underwent 1H-MRI of the lung at 1." | 1.42 | Morpho-Functional 1H-MRI of the Lung in COPD: Short-Term Test-Retest Reliability. ( Anjorin, A; Biederer, J; Jobst, BJ; Kauczor, HU; Ley, S; Ley-Zaporozhan, J; Sedlaczek, O; Triphan, SM; Wielpütz, MO, 2015) |
| "Chest MRI is increasingly used to assess pulmonary diseases, but its utility compared with high-resolution computed tomography (HRCT) has never been evaluated in children using specific performance outcomes." | 1.38 | Magnetic resonance imaging is an accurate and reliable method to evaluate non-cystic fibrosis paediatric lung disease. ( Aloj, G; Bruzzese, D; Esposito, A; Maglione, M; Manna, A; Mirra, V; Mollica, C; Montella, S; Pignata, C; Santamaria, F, 2012) |
| "Common variable immunodeficiency is characterized by defective antibody production and recurrent pulmonary infections." | 1.35 | Analysis of the sputum and inflammatory alterations of the airways in patients with common variable immunodeficiency and bronchiectasis. ( Kokron, CM; Lorenzi Filho, G; Negri, EM; Pereira, AC; Romagnolo, BM; Saldiva, PH; Yagi, CS, 2009) |
| "These findings suggest that bronchial asthma with mucoid impactions is among several pathogeneses that cause increased levels of CEA in serum and BALF." | 1.32 | [Concentrations of carcinoembryonic antigen in serum and bronchoalveolar lavage fluid of asthmatic patients with mucoid impaction]. ( Fukui, Y; Harada, T; Hizawa, N; Kikuchi, E; Maeda, Y; Nagai, K; Nishimura, M; Suko, N; Takahashi, D, 2004) |
| "Obstructive pneumonitis frequently occurs distal to hilar bronchogenic carcinomas or in lung adjacent to peripheral tumors." | 1.28 | Differentiation of bronchogenic carcinoma from postobstructive pneumonitis by magnetic resonance imaging: histopathologic correlation. ( Bourgouin, PM; Brady, TJ; Fitzgibbon, JF; Mark, EJ; McLoud, TC; Moore, EM; Rummeny, E; Shepard, JA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 50 (41.32) | 18.7374 |
| 1990's | 19 (15.70) | 18.2507 |
| 2000's | 17 (14.05) | 29.6817 |
| 2010's | 27 (22.31) | 24.3611 |
| 2020's | 8 (6.61) | 2.80 |
| Authors | Studies |
|---|---|
| TOWNLEY, RG | 1 |
| BRONSTEIN, SB | 1 |
| Wójcicki, J | 1 |
| Samochowiec, L | 1 |
| Szwed, G | 1 |
| Sawiński, J | 1 |
| Boselli, G | 1 |
| Brody, AS | 2 |
| Huang, R | 1 |
| Zhang, B | 1 |
| Long, FR | 2 |
| Powers, SW | 1 |
| Lu, HW | 1 |
| Mao, B | 1 |
| Wei, P | 1 |
| Jiang, S | 1 |
| Wang, H | 1 |
| Li, CW | 1 |
| Ji, XB | 1 |
| Gu, SY | 1 |
| Yang, JW | 1 |
| Liang, S | 1 |
| Cheng, KB | 1 |
| Bai, JW | 1 |
| Cao, WJ | 1 |
| Jia, XM | 1 |
| Xu, JF | 1 |
| Turcios, NL | 1 |
| Chalmers, JD | 2 |
| Sibila, O | 1 |
| Ehre, C | 1 |
| Robinson, TE | 1 |
| Goris, ML | 1 |
| Moss, RB | 1 |
| Tian, L | 1 |
| Kan, P | 1 |
| Yilma, M | 1 |
| McCoy, KS | 1 |
| Newman, B | 1 |
| de Jong, PA | 1 |
| Behrje, R | 1 |
| Yates, DP | 1 |
| Cornfield, DN | 1 |
| Bhatt, R | 1 |
| Ghosh, S | 1 |
| Handa, N | 1 |
| Tale, S | 1 |
| Keir, HR | 1 |
| Muñoz Castro, G | 1 |
| Balañá Corberó, A | 1 |
| Occelli, A | 1 |
| Soize, S | 1 |
| Ranc, C | 1 |
| Giovannini-Chami, L | 1 |
| Bailly, C | 1 |
| Leloutre, B | 1 |
| Boyer, C | 1 |
| Baque-Juston, M | 1 |
| Tambascio, J | 3 |
| de Souza, HCD | 2 |
| Martinez, R | 1 |
| Baddini-Martinez, JA | 2 |
| Barnes, PJ | 1 |
| Gastaldi, AC | 4 |
| Shen, Y | 1 |
| Huang, S | 1 |
| Kang, J | 1 |
| Lin, J | 1 |
| Lai, K | 1 |
| Sun, Y | 1 |
| Xiao, W | 1 |
| Yang, L | 1 |
| Yao, W | 1 |
| Cai, S | 1 |
| Huang, K | 1 |
| Wen, F | 1 |
| Dos Santos, DO | 1 |
| Ramos, EMC | 1 |
| Tran, TT | 2 |
| Vidaillac, C | 2 |
| Yu, H | 2 |
| Yong, VFL | 1 |
| Roizman, D | 1 |
| Chandrasekaran, R | 1 |
| Lim, AYH | 2 |
| Low, TB | 1 |
| Tan, GL | 1 |
| Abisheganaden, JA | 2 |
| Koh, MS | 1 |
| Teo, J | 1 |
| Chotirmall, SH | 2 |
| Hadinoto, K | 2 |
| Mochimaru, T | 1 |
| Fukunaga, K | 1 |
| Ueda, S | 1 |
| Kuroda, A | 1 |
| Watanabe, R | 1 |
| Chubachi, S | 1 |
| Betsuyaku, T | 1 |
| Boucher, RC | 1 |
| de Souza, HC | 2 |
| Martinez, JA | 1 |
| Afonso, JL | 1 |
| Jardim, JR | 2 |
| Montella, S | 2 |
| Mollica, C | 2 |
| Finocchi, A | 1 |
| Pession, A | 1 |
| Pietrogrande, MC | 1 |
| Trizzino, A | 1 |
| Ranucci, G | 1 |
| Maglione, M | 2 |
| Giardino, G | 1 |
| Salvatore, M | 1 |
| Santamaria, F | 2 |
| Pignata, C | 2 |
| Gehrig, S | 1 |
| Duerr, J | 1 |
| Weitnauer, M | 1 |
| Wagner, CJ | 1 |
| Graeber, SY | 1 |
| Schatterny, J | 1 |
| Hirtz, S | 1 |
| Belaaouaj, A | 1 |
| Dalpke, AH | 1 |
| Schultz, C | 1 |
| Mall, MA | 1 |
| Ramos, EM | 1 |
| Ramos, D | 1 |
| Moreira, GL | 1 |
| Macchione, M | 1 |
| Guimarães, ET | 1 |
| Rodrigues, FM | 1 |
| de Souza, AA | 1 |
| Saldiva, PH | 3 |
| Jobst, BJ | 1 |
| Wielpütz, MO | 1 |
| Triphan, SM | 1 |
| Anjorin, A | 1 |
| Ley-Zaporozhan, J | 1 |
| Kauczor, HU | 1 |
| Biederer, J | 1 |
| Ley, S | 1 |
| Sedlaczek, O | 1 |
| Arslan, S | 1 |
| Poyraz, N | 1 |
| Ucar, R | 1 |
| Yesildag, M | 1 |
| Yesildag, A | 1 |
| Caliskaner, AZ | 1 |
| Franchini, ML | 1 |
| Athanazio, R | 1 |
| Amato-Lourenço, LF | 1 |
| Carreirão-Neto, W | 1 |
| Lorenzi-Filho, G | 1 |
| Rubin, BK | 2 |
| Nakagawa, NK | 1 |
| Woodfield, G | 1 |
| Nisbet, M | 1 |
| Jacob, J | 1 |
| Mok, W | 1 |
| Loebinger, MR | 1 |
| Hansell, DM | 1 |
| Wells, AU | 2 |
| Wilson, R | 4 |
| Poncin, W | 1 |
| Reychler, G | 1 |
| Leeuwerck, N | 1 |
| Bauwens, N | 1 |
| Aubriot, AS | 1 |
| Nader, C | 1 |
| Liistro, G | 1 |
| Gohy, S | 1 |
| Pereira, AC | 1 |
| Kokron, CM | 1 |
| Romagnolo, BM | 1 |
| Yagi, CS | 1 |
| Lorenzi Filho, G | 1 |
| Negri, EM | 1 |
| Braman, SS | 2 |
| Abu-Hijleh, M | 1 |
| Daviskas, E | 3 |
| Anderson, SD | 2 |
| Eberl, S | 2 |
| Young, IH | 2 |
| Williams, BJ | 1 |
| Dehnbostel, J | 1 |
| Blackwell, TS | 1 |
| de Souza, LT | 1 |
| Lisboa, RM | 1 |
| Passarelli, Rde C | 1 |
| Bruzzese, D | 1 |
| Aloj, G | 1 |
| Manna, A | 1 |
| Esposito, A | 1 |
| Mirra, V | 1 |
| Agarwal, R | 2 |
| Khan, A | 1 |
| Aggarwal, AN | 2 |
| Varma, N | 1 |
| Garg, M | 1 |
| Saikia, B | 1 |
| Gupta, D | 2 |
| Chakrabarti, A | 2 |
| Miravitlles, M | 1 |
| Calle, M | 1 |
| Soler-Cataluña, JJ | 1 |
| Marsh, R | 1 |
| Gupta, A | 1 |
| Gilchrist, FJ | 1 |
| Puckey, M | 1 |
| Padley, SP | 1 |
| Hogg, C | 1 |
| Lenney, W | 1 |
| Bush, A | 2 |
| Nair, SR | 1 |
| Pearson, SB | 1 |
| Shibuya, Y | 1 |
| Wills, PJ | 2 |
| Cole, PJ | 6 |
| Edwards, EA | 1 |
| Metcalfe, R | 1 |
| Milne, DG | 1 |
| Thompson, J | 1 |
| Byrnes, CA | 1 |
| WILSON, W | 1 |
| CASTLEBERRY, MW | 1 |
| FERRELL, JF | 1 |
| JONES, LD | 1 |
| GARVIN, CH | 1 |
| Greenstone, M | 1 |
| Ratjen, F | 1 |
| Maeda, Y | 1 |
| Hizawa, N | 1 |
| Fukui, Y | 1 |
| Nagai, K | 1 |
| Kikuchi, E | 1 |
| Takahashi, D | 1 |
| Harada, T | 1 |
| Suko, N | 1 |
| Nishimura, M | 1 |
| Judge, EP | 1 |
| Dodd, JD | 1 |
| Masterson, JB | 1 |
| Gallagher, CG | 1 |
| Kadota, J | 1 |
| Palumbo, AA | 1 |
| Luccichenti, G | 1 |
| Belgrano, M | 1 |
| La Grutta, L | 1 |
| Runza, G | 1 |
| Cova, MA | 1 |
| Midiri, M | 1 |
| Pisi, G | 1 |
| Grzincich, GL | 1 |
| Battistini, A | 1 |
| Cademartiri, F | 1 |
| Saxena, AK | 1 |
| Jindal, SK | 1 |
| Crisafulli, E | 1 |
| Coletti, O | 1 |
| Costi, S | 1 |
| Zanasi, E | 1 |
| Lorenzi, C | 1 |
| Lucic, S | 1 |
| Fabbri, LM | 1 |
| Bertini, M | 1 |
| Clini, EM | 1 |
| Reid, L | 4 |
| Denton, R | 1 |
| Kwart, H | 1 |
| Litt, M | 1 |
| Potter, JL | 1 |
| Matthews, LW | 1 |
| Spector, S | 1 |
| Lemm, J | 1 |
| Bonforte, RJ | 1 |
| Gullotta, U | 1 |
| Daum, S | 1 |
| Parzinger, G | 1 |
| Schlehe, H | 1 |
| Wuttke, V | 1 |
| Proto, AV | 1 |
| Waite, DA | 2 |
| Wakefield, SJ | 2 |
| Moriarty, KM | 1 |
| Lewis, ME | 1 |
| Cuttance, PC | 1 |
| Scott, AG | 1 |
| Mackay, JB | 1 |
| Ross, IT | 2 |
| Allegra, L | 1 |
| Bossi, R | 1 |
| Braga, PC | 1 |
| Rutland, J | 1 |
| Ambrosino, N | 1 |
| Callegari, G | 1 |
| Galloni, C | 1 |
| Brega, S | 1 |
| Pinna, G | 1 |
| Brunner, P | 1 |
| Sedat, J | 1 |
| Padovani, B | 1 |
| Belaïdi, M | 1 |
| Marin, H | 1 |
| Ferrari, C | 1 |
| Mourou, MY | 1 |
| Bruneton, JN | 1 |
| Carr, DH | 1 |
| Oades, P | 1 |
| Trotman-Dickenson, B | 1 |
| Mohiaddin, R | 1 |
| Klein, A | 4 |
| Carnoy, C | 1 |
| Lamblin, G | 4 |
| Roussel, P | 5 |
| van Kuik, JA | 1 |
| Vliegenthart, JF | 4 |
| Hirashima, T | 1 |
| Tamanoi, M | 1 |
| Kojima, S | 1 |
| Ohhata, I | 1 |
| Araki, Y | 1 |
| Kawabata, S | 1 |
| Kimura, K | 1 |
| Hanamoto, S | 1 |
| Ochi, N | 1 |
| Kikui, M | 1 |
| Wodehouse, T | 1 |
| Corkery, K | 1 |
| Mallon, K | 1 |
| Grenier, P | 1 |
| Mourey-Gerosa, I | 1 |
| Benali, K | 1 |
| Brauner, MW | 1 |
| Leung, AN | 1 |
| Lenoir, S | 1 |
| Cordeau, MP | 1 |
| Mazoyer, B | 1 |
| Lin, HC | 1 |
| Cheng, HF | 1 |
| Wang, CH | 1 |
| Liu, CY | 1 |
| Yu, CT | 1 |
| Kuo, HP | 1 |
| Ruzal-Shapiro, C | 1 |
| Mikami, M | 1 |
| Llewellyn-Jones, CG | 1 |
| Bayley, D | 1 |
| Hill, SL | 2 |
| Stockley, RA | 2 |
| Cockrill, BA | 1 |
| Hales, CA | 1 |
| Mitchell, TA | 1 |
| Hamilos, DL | 1 |
| Lynch, DA | 1 |
| Newell, JD | 1 |
| Miyazaki, Y | 1 |
| Sakashita, H | 1 |
| Tanaka, T | 1 |
| Kamei, K | 1 |
| Nishimura, K | 1 |
| Yoshizawa, Y | 1 |
| Marchant, JM | 1 |
| Masel, JP | 1 |
| Dickinson, FL | 1 |
| Masters, IB | 1 |
| Chang, AB | 1 |
| Cole, P | 1 |
| Wallace, JC | 1 |
| Waite, D | 1 |
| Lopez-Vidriero, MT | 1 |
| Fahy, JV | 1 |
| Schuster, A | 1 |
| Ueki, I | 1 |
| Boushey, HA | 1 |
| Nadel, JA | 1 |
| Marty, N | 1 |
| Dournes, JL | 1 |
| Chabanon, G | 1 |
| Montrozier, H | 1 |
| Tamaoki, J | 1 |
| Chiyotani, A | 1 |
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| Sakai, N | 1 |
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| Lecuire, A | 1 |
| Zahm, JM | 1 |
| Puchelle, E | 1 |
| Bataillon, V | 1 |
| Lhermitte, M | 2 |
| Lafitte, JJ | 1 |
| Pommery, J | 1 |
| Bourgouin, PM | 1 |
| McLoud, TC | 1 |
| Fitzgibbon, JF | 1 |
| Mark, EJ | 1 |
| Shepard, JA | 1 |
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| Brady, TJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of the Effect of FLUTTER VRP1 in Patients With Bronchiectasis.[NCT01209546] | Phase 1 | 30 participants (Actual) | Interventional | 2007-07-31 | Terminated (stopped due to The protocol finished.) | ||
| The Efficacy of the AIRVO Warm Humidifier as an Add on to Oxygen Therapy as Well as Stand-alone Therapy in Patients With Respiratory Insufficiency[NCT03081650] | 30 participants (Anticipated) | Interventional | 2016-08-16 | Recruiting | |||
| Effects of Long-term Dry and Humidified Low-flow Oxygen Via Nasal Cannula on Nasal Mucociliary Clearance, Mucus Properties, Inflammation and Airway Symptoms in Patients[NCT02515786] | Phase 1/Phase 2 | 19 participants (Anticipated) | Interventional | 2013-01-31 | Active, not recruiting | ||
| Short-term Effects of Chest Physiotherapy on Ventilation Inhomogeneity in Non-CF Bronchiectasis[NCT02411981] | 24 participants (Actual) | Interventional | 2015-04-30 | Completed | |||
| Acute Effects of a Flutter Device and Chest Wall Compression on Respiratory System Impedance in Bronchiectasis Patients[NCT02509637] | 40 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| Efficacy and Safety of Fluticasone Furoate/Vilanterol vs. Umeclidinium/Vilanterol in Patients With COPD-asthma Phenotype vs. Emphysema Phenotype. A Controled Clinical Trial.[NCT05342558] | Phase 4 | 133 participants (Actual) | Interventional | 2017-09-19 | Completed | ||
| Raman Analysis of Saliva From COPD Patients as New Biomarker: AI-based Point-of-care for the Disease Monitoring and Management[NCT04628962] | 250 participants (Anticipated) | Observational | 2022-02-01 | Recruiting | |||
| A Prospective, Two-center, Clinical Study to Optimize the Treatment for Allergic Bronchopulmonary Aspergillosis (ABPA)[NCT05129033] | 100 participants (Anticipated) | Interventional | 2021-11-15 | Not yet recruiting | |||
| : A Phase III Multicenter, Randomized, Parallel Group, Controlled, Double Blind Study to Investigate the Safety and Efficacy of Inhaled Mannitol Over 12 Months in the Treatment of Bronchiectasis.[NCT00669331] | Phase 3 | 485 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| Evaluation of Oscillatory Positive Expiratory Pressure (oPEP) in Bronchiectasis and COPD[NCT02282202] | 32 participants (Actual) | Interventional | 2013-09-30 | Completed | |||
| Beatmungsdauer Und Lungenfunktion Bei Beatmeten Patienten Unter Therapie Mit Dornase Alfa - Randomisierte, Doppel-Blinde, Placebo-Kontrollierte, Multizentrische, Prospektive Klinische Studie[NCT00204685] | Phase 2/Phase 3 | 540 participants | Interventional | 2003-08-31 | Active, not recruiting | ||
| "Validation of a Questionnaire to Assess Bronchial Mucus Hypersecretion in Asthmatic Patients. Questionnaire T-sec (Secretion Test)."[NCT05546645] | 100 participants (Anticipated) | Observational | 2023-10-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Mean rate of hospitalisations (number/year) summarised and analysed to take account of differing follow-up times. (NCT00669331)
Timeframe: 52 weeks
| Intervention | hospitalisations/year (Mean) |
|---|---|
| Mannitol | 0.12 |
| Control | 0.20 |
Rate of antibiotic treated graded pulmonary exacerbations, using the same definition of a graded pulmonary exacerbation as the primary endpoint. A graded pulmonary exacerbation was considered to be anti-biotic treated if use of oral, IV or inhaled antibiotic use was recorded related to the GPE event. (NCT00669331)
Timeframe: 52 weeks
| Intervention | events/year (Number) |
|---|---|
| Mannitol | 1.9 |
| Control | 2.1 |
Duration of graded exacerbations is defined as the number of days with graded PE within one treatment year. Mean days estimated via negative binomial model with treatment, region and baseline pulmonary exacerbation rate as predictors, with log of follow-up time as the offset variable (NCT00669331)
Timeframe: 52 weeks
| Intervention | Days with GPE (Mean) |
|---|---|
| Mannitol | 31.49 |
| Control | 35.74 |
(NCT00669331)
Timeframe: 52 weeks
| Intervention | mL/s (Least Squares Mean) |
|---|---|
| Mannitol | -18.21 |
| Control | -3.40 |
(NCT00669331)
Timeframe: 52 weeks
| Intervention | mL (Least Squares Mean) |
|---|---|
| Mannitol | 2.36 |
| Control | -5.20 |
FEV1 expressed as a ratio of FVC. Endpoint is expressed as a percentage ie FEV1/FVC*100 (NCT00669331)
Timeframe: 52 weeks
| Intervention | ratio (expressed as a %) (Least Squares Mean) |
|---|---|
| Mannitol | -0.08 |
| Control | 0.09 |
(NCT00669331)
Timeframe: 52 weeks
| Intervention | mL (Least Squares Mean) |
|---|---|
| Mannitol | 0.15 |
| Control | -15.70 |
hematology assessed as clinically significant abnormal FBC (Full Blood count) at any point post baseline. (NCT00669331)
Timeframe: 52 weeks
| Intervention | participants (Number) |
|---|---|
| Mannitol | 13 |
| Control | 5 |
sputum microbiology assessed as the presence of abnormal flora in sputum sample taken at any post baseline visit (NCT00669331)
Timeframe: 52 weeks
| Intervention | participants (Number) |
|---|---|
| Mannitol | 81 |
| Control | 81 |
Time to first graded exacerbation is defined as the duration (in months) from the randomisation date to the start of the first reported graded PE during the on-treatment period. Patients without reported graded PE event will be censored at the last participation. (NCT00669331)
Timeframe: 52 weeks
| Intervention | months (Median) |
|---|---|
| Mannitol | 5.4 |
| Control | 4.1 |
Epworth Sleepiness Scale (ESS) score was calculated as the sum of scores for each of eight individual questions, such that a total score of zero represents no daytime sleepiness, and a total score of 24 represents the maximum degree of daytime sleepiness. Measured at baseline, 6 weeks, 16 weeks, 28 weeks, 40 weeks, 52 weeks (NCT00669331)
Timeframe: 52 weeks
| Intervention | units on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| Baseline | Week 6 | Week 16 | Week 28 | Week 40 | Week 52 | |
| Control | 6.89 | 6.87 | 6.50 | 6.57 | 6.33 | 6.34 |
| Mannitol | 7.23 | 6.07 | 6.21 | 6.05 | 6.32 | 6.09 |
The SGRQ was collected at baseline, week 6, week 16, week 28, week 40 and week 52. Change in total score was calculated from baseline. Total scores are a weighted sum across all questions. Scores are expressed as a percentage of overall impairment where 100 represents worst possible health status and 0 indicates best possible health status. Higher scores indicate lower quality of life. Outcome data table gives the raw mean total score at each visit. (NCT00669331)
Timeframe: 52 weeks
| Intervention | units on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| Baseline | Week 6 | Week 16 | Week 28 | Week 40 | Week 52 | |
| Control | 52.22 | 44.55 | 44.23 | 43.46 | 43.51 | 42.25 |
| Mannitol | 52.98 | 44.09 | 40.67 | 41.45 | 40.39 | 41.43 |
A graded pulmonary exacerbation was defined as a worsening in signs and symptoms requiring a change in treatment (Center for Drug Evaluation and Research (CDER), 2007). Grade I was required 3 main signs and symptoms, Grade II 2 main signs and symptoms and Grade III 1 main and one or more minor signs and symptoms. Main signs and symptoms were increased cough, sputum volume or sputum purulence. Minor were upper respiratory tract infection, fever, increased wheezing, increased dyspnea, increase in respiratory rate, increase in cardiac frequency of >20%, and increased malaise, fatigue or lethargy. Rate is defined as the number of all GPE events observed in one treatment year (NCT00669331)
Timeframe: 52 weeks
| Intervention | GPE events per year (Number) | |
|---|---|---|
| Raw rate | Rate from negative binomial model | |
| Control | 2.10 | 1.84 |
| Mannitol | 1.95 | 1.69 |
Clinical chemistry was assessed as clinically significant abnormal liver function test and clinically significant abnormal urea/electrolyte test at any point post baseline. (NCT00669331)
Timeframe: 52 weeks
| Intervention | participants (Number) | |
|---|---|---|
| Subjects with Clin sig liver funtion tests at wk52 | Subjects with clin sig urea/electrolyte test wk52 | |
| Control | 0 | 0 |
| Mannitol | 2 | 3 |
24 hour sputum weight, measured at baseline, week 6, week 16, week 28, week 40, week 52 (NCT00669331)
Timeframe: 52 weeks
| Intervention | g (Mean) | |||||
|---|---|---|---|---|---|---|
| Baseline | Week 6 | Week 16 | Week 28 | Week 40 | Week 52 | |
| Control | 28.96 | 22.82 | 20.25 | 18.88 | 18.17 | 18.33 |
| Mannitol | 28.88 | 24.97 | 23.69 | 22.92 | 21.56 | 20.54 |
13 reviews available for guaifenesin and Bronchiectasis
| Article | Year |
|---|---|
Cystic Fibrosis Lung Disease: An Overview.
Topics: Bronchiectasis; Cystic Fibrosis; Humans; Lung; Mucociliary Clearance; Mucus | 2020 |
Management of airway mucus hypersecretion in chronic airway inflammatory disease: Chinese expert consensus (English edition).
Topics: Animals; Asthma; Bronchiectasis; China; Consensus; Cystic Fibrosis; Drainage; Expectorants; Humans; | 2018 |
Muco-Obstructive Lung Diseases.
Topics: Bronchiectasis; Cilia; Cystic Fibrosis; Disease Progression; Expectorants; Humans; Lung Diseases, Ob | 2019 |
Pseudomonas aeruginosa: host defence in lung diseases.
Topics: Animals; Biofilms; Bronchiectasis; Bronchiolitis Obliterans; Cross Infection; Cystic Fibrosis; Cytok | 2010 |
Clinical phenotypes of COPD: identification, definition and implications for guidelines.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Asthma; Bronchiectasis; Bronchitis; Bronchodilato | 2012 |
Clinical phenotypes of COPD: identification, definition and implications for guidelines.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Asthma; Bronchiectasis; Bronchitis; Bronchodilato | 2012 |
Clinical phenotypes of COPD: identification, definition and implications for guidelines.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Asthma; Bronchiectasis; Bronchitis; Bronchodilato | 2012 |
Clinical phenotypes of COPD: identification, definition and implications for guidelines.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Asthma; Bronchiectasis; Bronchitis; Bronchodilato | 2012 |
Effect of inhaled dry powder mannitol on mucus and its clearance.
Topics: Administration, Inhalation; Bronchiectasis; Cystic Fibrosis; Dry Powder Inhalers; Humans; Mannitol; | 2013 |
Changing paradigms in the diagnosis and management of bronchiectasis.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Biomarkers; Bromhexine; Bronchiectasis; Forecasting; | 2002 |
[Pathophysiology of chronic airway infections].
Topics: Anti-Bacterial Agents; Body Water; Bronchiectasis; Bronchiolitis; Bronchitis, Chronic; Cystic Fibros | 2006 |
[A case of multiple broncholithiasis caused by mucus retention].
Topics: Adult; Aged; Bronchial Diseases; Bronchiectasis; Calcinosis; Calcium Carbonate; Female; Humans; Male | 1993 |
Cystic fibrosis. An overview.
Topics: Bile Duct Diseases; Bronchiectasis; Cystic Fibrosis; Exocrine Pancreatic Insufficiency; Humans; Lung | 1998 |
Allergic bronchopulmonary aspergillosis.
Topics: Administration, Oral; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Asthma; Bronc | 1999 |
Pathophysiology and treatment of airway mucociliary clearance. A moving tale.
Topics: Bronchiectasis; Cilia; Ciliary Motility Disorders; Humans; Mucociliary Clearance; Mucus; Otitis; Sin | 2001 |
The pathology of obstructive and inflammatory airway diseases.
Topics: Animals; Asthma; Bronchi; Bronchiectasis; Bronchiolitis, Viral; Bronchitis; Child; Dogs; Humans; Lun | 1986 |
13 trials available for guaifenesin and Bronchiectasis
| Article | Year |
|---|---|
The use of Duopect as expectorant--antitussive agent.
Topics: Adolescent; Adult; Aged; Asthma; Bronchiectasis; Bronchitis; Chronic Disease; Clinical Trials as Top | 1975 |
Effects of an Airway Clearance Device on Inflammation, Bacteriology, and Mucus Transport in Bronchiectasis.
Topics: Adult; Aged; Aged, 80 and over; Airway Management; Bronchiectasis; Cough; Cross-Over Studies; Female | 2017 |
Effects of exercise on secretion transport, inflammation, and quality of life in patients with noncystic fibrosis bronchiectasis: Protocol for a randomized controlled trial.
Topics: Adolescent; Adult; Bronchiectasis; Clinical Protocols; Exercise; Exercise Therapy; Female; Heart Rat | 2018 |
Oxygen With Cold Bubble Humidification Is No Better Than Dry Oxygen in Preventing Mucus Dehydration, Decreased Mucociliary Clearance, and Decline in Pulmonary Function.
Topics: Aged; Aged, 80 and over; Bronchiectasis; Cough; Cytokines; Disease Progression; Epidermal Growth Fac | 2016 |
Oxygen With Cold Bubble Humidification Is No Better Than Dry Oxygen in Preventing Mucus Dehydration, Decreased Mucociliary Clearance, and Decline in Pulmonary Function.
Topics: Aged; Aged, 80 and over; Bronchiectasis; Cough; Cytokines; Disease Progression; Epidermal Growth Fac | 2016 |
Oxygen With Cold Bubble Humidification Is No Better Than Dry Oxygen in Preventing Mucus Dehydration, Decreased Mucociliary Clearance, and Decline in Pulmonary Function.
Topics: Aged; Aged, 80 and over; Bronchiectasis; Cough; Cytokines; Disease Progression; Epidermal Growth Fac | 2016 |
Oxygen With Cold Bubble Humidification Is No Better Than Dry Oxygen in Preventing Mucus Dehydration, Decreased Mucociliary Clearance, and Decline in Pulmonary Function.
Topics: Aged; Aged, 80 and over; Bronchiectasis; Cough; Cytokines; Disease Progression; Epidermal Growth Fac | 2016 |
Beneficial effect of inhaled mannitol and cough in asthmatics with mucociliary dysfunction.
Topics: Administration, Inhalation; Adult; Aged; Bronchiectasis; Cough; Dose-Response Relationship, Drug; Fe | 2010 |
The influence of Flutter®VRP1 components on mucus transport of patients with bronchiectasis.
Topics: Bronchiectasis; Chest Wall Oscillation; Cross-Over Studies; Equipment Design; Female; Humans; Linear | 2011 |
Effectiveness of erdosteine in elderly patients with bronchiectasis and hypersecretion: a 15-day, prospective, parallel, open-label, pilot study.
Topics: Administration, Oral; Aged; Bronchiectasis; Chronic Disease; Combined Modality Therapy; Expectorants | 2007 |
Effect of increasing doses of mannitol on mucus clearance in patients with bronchiectasis.
Topics: Administration, Inhalation; Aged; Bronchiectasis; Cough; Diuretics, Osmotic; Dose-Response Relations | 2008 |
Clinical evaluation of oscillating positive expiratory pressure for enhancing expectoration in diseases other than cystic fibrosis.
Topics: Aged; Bronchiectasis; Bronchitis; Cough; Cystic Fibrosis; Drainage, Postural; Female; Humans; Lung D | 1995 |
Short-term recombinant human DNase in bronchiectasis. Effect on clinical state and in vitro sputum transportability.
Topics: Administration, Inhalation; Adult; Aerosols; Aged; Animals; Bronchiectasis; Cattle; Deoxyribonucleas | 1996 |
Inhaled gentamicin reduces airway neutrophil activity and mucus secretion in bronchiectasis.
Topics: Administration, Inhalation; Aged; Anti-Bacterial Agents; Bronchi; Bronchiectasis; Double-Blind Metho | 1997 |
Effect of indomethacin on bronchorrhea in patients with chronic bronchitis, diffuse panbronchiolitis, or bronchiectasis.
Topics: Adult; Aged; Bronchi; Bronchiectasis; Bronchitis; Chronic Disease; Double-Blind Method; Female; Huma | 1992 |
A new mucolytic, bromhexine ("bisolvon"). A double-blind study.
Topics: Aniline Compounds; Asthma; Bronchiectasis; Bronchitis; Clinical Trials as Topic; Expectorants; Femal | 1971 |
95 other studies available for guaifenesin and Bronchiectasis
| Article | Year |
|---|---|
A DOUBLE BLIND CLINICAL EVALUATION OF GLYCERYL GUAIACOLATE.
Topics: Asthma; Bronchiectasis; Bronchitis; Choline; Cough; Double-Blind Method; Guaifenesin; Pulmonary Emph | 1963 |
[Therapeutic activity of an association of a mucolytic drug and a bronchodilator agent in the treatment of respiratory inflammations].
Topics: Bronchiectasis; Bronchitis; Bronchodilator Agents; Bronchopneumonia; Chronic Disease; Cough; Drug Co | 1973 |
Structural lung disease in preschool children with cystic fibrosis: An 18 month natural history study.
Topics: Bronchiectasis; Child; Child, Preschool; Cystic Fibrosis; Humans; Lung; Mucus; Respiratory Function | 2022 |
The clinical characteristics and prognosis of ABPA are closely related to the mucus plugs in central bronchiectasis.
Topics: Adult; Aspergillus; Bronchiectasis; Bronchoscopy; Female; Follow-Up Studies; Humans; Male; Middle Ag | 2020 |
Happy Birthday, Bronchiectasis: 200 Years of Targeting Mucus.
Topics: Bronchiectasis; Fibrosis; Humans; Mucus; Respiratory System | 2020 |
[Mucus buildup: the starting point of cystic fibrosis lung disease pathogenesis].
Topics: Bronchiectasis; Child; Child, Preschool; Cilia; Cystic Fibrosis; Cystic Fibrosis Transmembrane Condu | 2019 |
Mucus plugging, air trapping, and bronchiectasis are important outcome measures in assessing progressive childhood cystic fibrosis lung disease.
Topics: Adolescent; Bronchi; Bronchiectasis; Child; Cystic Fibrosis; Disease Progression; Female; Forced Exp | 2020 |
Interesting case of allergic broncho pulmonary aspergillosis (ABPA) with high-attenuation mucus (HAM).
Topics: Adult; Aspergillosis, Allergic Bronchopulmonary; Asthma; Bronchiectasis; Humans; Lung; Male; Mucus | 2021 |
Pathophysiology of Bronchiectasis.
Topics: Bronchiectasis; Humans; Inflammation; Mucociliary Clearance; Mucus; Persistent Infection | 2021 |
Airway Clearance and Mucoactive Therapies.
Topics: Bronchiectasis; Humans; Mucociliary Clearance; Mucus; Respiratory System; Respiratory Therapy | 2021 |
Bronchocele density in cystic fibrosis as an indicator of allergic broncho-pulmonary aspergillosis: A preliminary study.
Topics: Adolescent; Aspergillosis, Allergic Bronchopulmonary; Bronchiectasis; Child; Child, Preschool; Cysti | 2017 |
A new therapeutic avenue for bronchiectasis: Dry powder inhaler of ciprofloxacin nanoplex exhibits superior ex vivo mucus permeability and antibacterial efficacy to its native ciprofloxacin counterpart.
Topics: Administration, Inhalation; Anti-Bacterial Agents; Bronchiectasis; Case-Control Studies; Chemistry, | 2018 |
Allergic bronchopulmonary aspergillosis in succession to chronic eosinophilic pneumonia.
Topics: Adult; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Bronchiectasis; Chronic Dise | 2019 |
An evaluation of inhaled antibiotic liposome versus antibiotic nanoplex in controlling infection in bronchiectasis.
Topics: A549 Cells; Administration, Inhalation; Adult; Anti-Bacterial Agents; Bronchiectasis; Cell Line, Tum | 2019 |
The influence of purulence on ciliary and cough transport in bronchiectasis.
Topics: Adult; Aged; Bronchiectasis; Cough; Female; Humans; Male; Mucociliary Clearance; Mucus; Patient Sele | 2013 |
Non invasive assessment of lung disease in ataxia telangiectasia by high-field magnetic resonance imaging.
Topics: Adolescent; Adult; Ataxia Telangiectasia; Bronchiectasis; Child; Disease Progression; Feasibility St | 2013 |
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease.
Topics: Airway Obstruction; Animals; Bronchiectasis; Cystic Fibrosis; Disease Models, Animal; Epithelial Sod | 2014 |
Viscoelastic properties of bronchial mucus after respiratory physiotherapy in subjects with bronchiectasis.
Topics: Adolescent; Adult; Aged; Bronchi; Bronchiectasis; Cough; Elasticity; Female; Humans; Male; Middle Ag | 2015 |
Morpho-Functional 1H-MRI of the Lung in COPD: Short-Term Test-Retest Reliability.
Topics: Aged; Bronchiectasis; Female; Humans; Lung; Magnetic Resonance Imaging; Male; Middle Aged; Mucus; Pe | 2015 |
Magnetic Resonance Imaging May Be a Valuable Radiation-Free Technique for Lung Pathologies in Patients with Primary Immunodeficiency.
Topics: Adult; Bronchiectasis; Female; Humans; Immunologic Deficiency Syndromes; Lung; Magnetic Resonance Im | 2016 |
Bronchiectasis in yellow nail syndrome.
Topics: Age of Onset; Aged; Anti-Bacterial Agents; Bronchiectasis; Case-Control Studies; Female; Humans; Mac | 2017 |
Short-Term Effect of Autogenic Drainage on Ventilation Inhomogeneity in Adult Subjects With Stable Non-Cystic Fibrosis Bronchiectasis.
Topics: Adult; Aged; Aged, 80 and over; Bronchiectasis; Drainage, Postural; Female; Humans; Lung; Male; Midd | 2017 |
Analysis of the sputum and inflammatory alterations of the airways in patients with common variable immunodeficiency and bronchiectasis.
Topics: Adult; Bronchiectasis; Cell Count; Common Variable Immunodeficiency; Cough; Female; Humans; Immunogl | 2009 |
The spectrum of nonasthmatic inflammatory airway diseases in adults.
Topics: Adrenal Cortex Hormones; Adult; Bronchial Diseases; Bronchiectasis; Bronchiolitis; Bronchitis, Chron | 2010 |
Magnetic resonance imaging is an accurate and reliable method to evaluate non-cystic fibrosis paediatric lung disease.
Topics: Adolescent; Blister; Bronchiectasis; Child; Child, Preschool; Female; Humans; Kartagener Syndrome; L | 2012 |
Clinical relevance of peripheral blood eosinophil count in allergic bronchopulmonary aspergillosis.
Topics: Adult; Antibodies, Fungal; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Bronchie | 2011 |
The trachea with an air-fluid level: a rare and bizarre radiological sign.
Topics: Adolescent; Bronchiectasis; Child; Cough; Female; Humans; Mucus; Respiratory Tract Infections; Tomog | 2012 |
Images in clinical medicine. Mucous plug in the bronchus causing lung collapse.
Topics: Aged; Airway Obstruction; Bronchi; Bronchial Diseases; Bronchiectasis; Bronchoscopy; Female; Humans; | 2002 |
Effect of osmolality on mucociliary transportability and rheology of cystic fibrosis and bronchiectasis sputum.
Topics: Bronchiectasis; Cystic Fibrosis; Elasticity; Humans; Mucociliary Clearance; Mucus; Osmolar Concentra | 2003 |
Retrospective review of children presenting with non cystic fibrosis bronchiectasis: HRCT features and clinical relationships.
Topics: Adolescent; Bronchiectasis; Child; Child, Preschool; Female; Forced Expiratory Flow Rates; Forced Ex | 2003 |
MUCOID IMPACTION OF THE BRONCHI.
Topics: Asthma; Bronchi; Bronchial Diseases; Bronchiectasis; Bronchoscopy; Humans; Mucus; Pulmonary Atelecta | 1964 |
MUCOID IMPACTION OF THE CANINE BRONCHI.
Topics: Animals; Bronchi; Bronchial Diseases; Bronchiectasis; Dog Diseases; Dogs; Mucins; Mucus; Pathology, | 1965 |
Dornase in non-CF.
Topics: Bronchiectasis; Bronchiolitis; Ciliary Motility Disorders; Deoxyribonuclease I; Humans; Mucus; Pulmo | 2004 |
[Concentrations of carcinoembryonic antigen in serum and bronchoalveolar lavage fluid of asthmatic patients with mucoid impaction].
Topics: Aged; Airway Obstruction; Asthma; Bronchial Diseases; Bronchiectasis; Bronchoalveolar Lavage Fluid; | 2004 |
Pulmonary abnormalities on high-resolution CT demonstrate more rapid decline than FEV1 in adults with cystic fibrosis.
Topics: Adolescent; Adult; Analysis of Variance; Bronchiectasis; Cystic Fibrosis; Female; Forced Expiratory | 2006 |
Three-dimensional quantitative assessment of lung parenchyma in cystic fibrosis: preliminary results.
Topics: Adolescent; Algorithms; Bronchi; Bronchiectasis; Bronchography; Cineradiography; Cystic Fibrosis; Da | 2007 |
Clinical significance of hyperattenuating mucoid impaction in allergic bronchopulmonary aspergillosis: an analysis of 155 patients.
Topics: Adult; Aspergillosis, Allergic Bronchopulmonary; Bronchiectasis; Female; Humans; Male; Mucus; Multiv | 2007 |
Mucus in respiratory disease.
Topics: Bronchiectasis; Bronchitis; Humans; Mucus; Pulmonary Emphysema; Respiratory Tract Diseases; Sputum | 1967 |
N-acetylcysteine in cystic fibrosis. Mechanical and chemical factors in treatment by aerosol.
Topics: Acetylcysteine; Adolescent; Adult; Aerosols; Agammaglobulinemia; Bronchiectasis; Child; Child, Presc | 1967 |
Studies on pulmonary secretions. II. Osmolality and the ionic environment of pulmonary secretions from patients with cystic fibrosis, bronchiectasis, and laryngectomy.
Topics: Amino Acids; Bronchiectasis; Calcium; Carbohydrates; Chlorides; Cystic Fibrosis; Humans; Laryngectom | 1967 |
Pseudomonas aeruginosa mucoid strain: its significance in adult chest diseases.
Topics: Bronchiectasis; Cystic Fibrosis; Humans; Mucus; Pseudomonas aeruginosa | 1983 |
[The mucoid impaction and the "mucous bronchogram" (author's transl)].
Topics: Adult; Bronchi; Bronchiectasis; Bronchitis; Bronchography; Female; Humans; Male; Middle Aged; Mucus | 1980 |
Evaluation of the bronchi with CT.
Topics: Bronchi; Bronchial Diseases; Bronchial Neoplasms; Bronchiectasis; Bronchography; Bronchopneumonia; B | 1984 |
Polynesian bronchiectasis.
Topics: Adolescent; Bronchiectasis; Child; Cilia; Complement System Proteins; Female; Humans; Immunoglobulin | 1983 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 50-1983. A 72-year-old woman with pulmonary infiltrates.
Topics: Aged; Biopsy; Bronchi; Bronchiectasis; Bronchitis; Diagnosis, Differential; Female; Humans; Lung; Lu | 1983 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1982. A 51-year-old woman with chronic asthma and hemoptysis.
Topics: Aspergillosis, Allergic Bronchopulmonary; Asthma; Bronchi; Bronchial Diseases; Bronchiectasis; Diagn | 1982 |
Mucociliary transport and ultrastructural abnormalities in Polynesian bronchiectasis.
Topics: Bronchi; Bronchiectasis; Cilia; Humans; Lung; Mucus; Nasal Mucosa; New Zealand; Polynesia | 1981 |
Action of sobrerol on mucociliary transport.
Topics: Adult; Aged; Animals; Biological Transport; Bronchiectasis; Bronchitis; Cilia; Expectorants; Female; | 1981 |
Nasal mucociliary clearance and ciliary beat frequency in cystic fibrosis compared with sinusitis and bronchiectasis.
Topics: Adolescent; Adult; Bronchiectasis; Cilia; Cystic Fibrosis; Humans; Mucus; Nasal Mucosa; Sinusitis; T | 1981 |
[Giant bronchopyocele. General and radiological characteristics. Apropos of a case].
Topics: Bronchi; Bronchial Diseases; Bronchiectasis; Humans; Male; Middle Aged; Mucus; Radiography; Suppurat | 1995 |
Magnetic resonance scanning in cystic fibrosis: comparison with computed tomography.
Topics: Adolescent; Adult; Bronchi; Bronchiectasis; Bronchography; Child; Cystic Fibrosis; Dilatation, Patho | 1995 |
Isolation and structural characterization of novel sialylated oligosaccharide-alditols from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis.
Topics: Bronchiectasis; Carbohydrate Sequence; Chromatography, Gel; Chromatography, High Pressure Liquid; Ch | 1993 |
Abnormalities of the airways and lung parenchyma in asthmatics: CT observations in 50 patients and inter- and intraobserver variability.
Topics: Adult; Aged; Aged, 80 and over; Asthma; Bronchi; Bronchiectasis; Bronchography; Female; Forced Expir | 1996 |
The chemotactic activity of sputum from patients with bronchiectasis.
Topics: Acute Disease; Anti-Bacterial Agents; Antibodies, Monoclonal; Benzoates; Bronchiectasis; Bronchitis; | 1998 |
Distribution and severity of bronchiectasis in allergic bronchopulmonary aspergillosis (ABPA).
Topics: Aspergillosis, Allergic Bronchopulmonary; Asthma; Bronchi; Bronchiectasis; Bronchography; Humans; Mu | 2000 |
Mucoid impaction caused by monokaryotic mycelium of Schizophyllum commune in association with bronchiectasis.
Topics: Antibodies, Fungal; Bronchi; Bronchiectasis; Bronchography; Diagnosis, Differential; Female; Humans; | 2000 |
Application of chest high-resolution computer tomography in young children with cystic fibrosis.
Topics: Age Factors; Bronchiectasis; Bronchography; Child; Child, Preschool; Cystic Fibrosis; Female; Forced | 2001 |
A simplified method of monitoring muco-ciliary transport.
Topics: Bronchiectasis; Cilia; Humans; Lung; Monitoring, Physiologic; Mucus; Posture; Radionuclide Imaging; | 1979 |
Chemical markers of mucous and serum glycoproteins and their relation to viscosity in mucoid and purulent sputum from various hypersecretory diseases.
Topics: Asthma; Bronchial Diseases; Bronchiectasis; Bronchitis; Chronic Disease; Cystic Fibrosis; Female; Fu | 1978 |
Mucus hypersecretion in bronchiectasis. The role of neutrophil proteases.
Topics: Adult; Aged; Animals; Aprotinin; Bronchiectasis; Cathepsin G; Cathepsins; Cattle; Cells, Cultured; F | 1992 |
Influence of nutrient media on the chemical composition of the exopolysaccharide from mucoid and non-mucoid Pseudomonas aeruginosa.
Topics: Alginates; Bronchiectasis; Culture Media; Cystic Fibrosis; Glucuronic Acid; Hexuronic Acids; Humans; | 1992 |
Phospholipid composition and surface-active properties of tracheobronchial secretions from patients with cystic fibrosis and chronic obstructive pulmonary diseases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bronchiectasis; Child; Cystic Fibrosis; Humans; Lung Dis | 1992 |
The binding of amikacin to macromolecules from the sputum of patients suffering from respiratory diseases.
Topics: Amikacin; Anti-Bacterial Agents; Bronchiectasis; Bronchitis; Chronic Disease; Cystic Fibrosis; Human | 1992 |
Differentiation of bronchogenic carcinoma from postobstructive pneumonitis by magnetic resonance imaging: histopathologic correlation.
Topics: Aged; Bronchiectasis; Carcinoma, Bronchogenic; Cholesterol; Diagnosis, Differential; Female; Humans; | 1991 |
Ultrafast computerized tomography of the chest in cystic fibrosis: a new scoring system.
Topics: Adolescent; Adult; Bronchiectasis; Child; Child, Preschool; Cystic Fibrosis; Humans; Infant; Mucus; | 1991 |
Mucoid impaction of upper lobe bronchi in the absence of proximal bronchiectasis.
Topics: Adult; Asthma; Bronchi; Bronchiectasis; Bronchography; Female; Humans; Lung; Mucus | 1990 |
Chest pain in chronic sputum production: a neglected symptom.
Topics: Bronchiectasis; Chest Pain; Humans; Lung; Mucus | 1989 |
The computed tomography mucous bronchogram sign.
Topics: Bronchiectasis; Bronchography; Carcinoma, Bronchogenic; Ciliary Motility Disorders; Humans; Lung Neo | 1988 |
Isolation and structural characterization of low-molecular-mass monosialyl oligosaccharides derived from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis.
Topics: Amino Acids; Borohydrides; Bronchiectasis; Carbohydrate Conformation; Carbohydrate Sequence; Carbohy | 1988 |
Neutrophil chemotaxis in bronchiectasis: a study of peripheral cells and lung secretions.
Topics: Adult; Aged; Amoxicillin; Bronchiectasis; Chemotactic Factors; Chemotaxis, Leukocyte; Female; Humans | 1988 |
Primary structure of neutral oligosaccharides derived from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis, determined by combination of 500-MHz 1H-NMR spectroscopy and quantitative sugar analysis. 1. Structure of 16 oligosaccha
Topics: Bronchiectasis; Carbohydrate Conformation; Carbohydrate Sequence; Carbohydrates; Chromatography, Hig | 1988 |
Primary structure of neutral oligosaccharides derived from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis, determined by combination of 500-MHz 1H-NMR spectroscopy and quantitative sugar analysis. 2. Structure of 19 oligosaccha
Topics: Bronchiectasis; Carbohydrate Conformation; Carbohydrate Sequence; Carbohydrates; Chromatography, Hig | 1988 |
Mucociliary clearance in relation to clinical features in patients with bronchiectasis.
Topics: Adult; Bronchiectasis; Cilia; Female; Humans; Lung; Male; Metabolic Clearance Rate; Middle Aged; Muc | 1986 |
Nasal mucus clearance.
Topics: Adolescent; Adult; Bronchiectasis; Female; Humans; Kartagener Syndrome; Male; Mucus; Nasal Mucosa; N | 1986 |
Beat frequency of cilia from sites of purulent infection.
Topics: Adolescent; Adult; Aged; Bronchiectasis; Child; Cilia; Female; Humans; Male; Middle Aged; Mucus; Nas | 1986 |
Plastic bronchitis: large, branching, mucoid bronchial casts in children.
Topics: Asthma; Bronchi; Bronchiectasis; Bronchitis; Bronchoscopy; Child; Child, Preschool; Female; Humans; | 1985 |
Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease.
Topics: Adolescent; Adult; Asthma; Bronchiectasis; Cilia; Female; Humans; Male; Middle Aged; Mucus; Nose; Rh | 1985 |
[A case of allergic bronchopulmonary aspergillosis with mucoid impaction of the bronchi].
Topics: Aspergillosis, Allergic Bronchopulmonary; Bronchi; Bronchiectasis; Humans; Lung Abscess; Male; Middl | 1985 |
Sputum viscosity in cystic fibrosis.
Topics: Bronchiectasis; Bronchitis; Cystic Fibrosis; Diagnosis, Differential; Humans; Mucus; Sputum; Viscosi | 1970 |
[Clinical value of liquifying drugs of bronchial secretions].
Topics: Alkaloids; Anti-Bacterial Agents; Anti-Inflammatory Agents; Atropine; Bronchi; Bronchiectasis; Bronc | 1970 |
The physical and chemical properties of bronchial secretion.
Topics: Asthma; Bronchi; Bronchiectasis; Bronchitis; Glycoproteins; Molecular Conformation; Mucus; Rheology; | 1974 |
Bronchography in childhood asthma.
Topics: Adolescent; Anesthesia, General; Asthma; Bronchi; Bronchial Spasm; Bronchiectasis; Bronchitis; Bronc | 1972 |
Rare complications of bronchial asthma.
Topics: Adult; Aged; Airway Obstruction; Allergens; Asthma; Bronchial Neoplasms; Bronchiectasis; Bronchitis; | 1972 |
Mucoid impaction of the bronchus.
Topics: Adolescent; Adult; Bronchial Diseases; Bronchiectasis; Bronchography; Bronchoscopy; Diagnosis, Diffe | 1973 |
[IgA of bronchial secretions].
Topics: Bronchi; Bronchiectasis; Child; Humans; Immunoglobulin A; Immunoglobulin G; Mucus; Respiratory Tract | 1973 |
[Results of bronchologic studies in children with bronchial asthma syndrome].
Topics: Adolescent; Asthma; Biopsy; Bronchi; Bronchial Diseases; Bronchiectasis; Bronchitis; Bronchoscopy; C | 1969 |
The histochemical type of glycoprotein produced by mucous cells of normal and diseased bronchi in childhood.
Topics: Bronchi; Bronchiectasis; Child; Child, Preschool; Cystic Fibrosis; Glycoproteins; Humans; Mucins; Mu | 1971 |
[Radiologic symptoms of chronic bronchitis].
Topics: Bronchiectasis; Bronchitis; Bronchography; Chronic Disease; Diagnosis, Differential; Humans; Mucus; | 1971 |
The resistance of small airways in normal and diseased human lungs.
Topics: Bronchi; Bronchiectasis; Bronchitis; Chronic Disease; Humans; Methods; Mucus; Pulmonary Emphysema | 1967 |
Site and nature of airway obstruction in chronic obstructive lung disease.
Topics: Bronchi; Bronchiectasis; Bronchitis; Bronchography; Bronchopneumonia; Catheterization; Chronic Disea | 1968 |
Pulmonary changes and cor pulmonale in mucoviscidosis.
Topics: Adult; Bronchiectasis; Bronchopneumonia; Child; Child, Preschool; Cystic Fibrosis; Female; Granulati | 1968 |
Bacterial flora of bronchial secretion.
Topics: Adolescent; Anti-Bacterial Agents; Asthma; Bacteria; Bronchi; Bronchial Diseases; Bronchiectasis; Br | 1968 |
Some principles of interpretation of bronchograms.
Topics: Bronchi; Bronchiectasis; Bronchography; Humans; Mucus | 1969 |
The bronchographic appearances of early chronic bronchitis.
Topics: Asthma; Bronchiectasis; Bronchitis; Bronchography; Chronic Disease; Female; Humans; Male; Mucus; Smo | 1969 |
Roentgenographic features of mucoid impaction of the bronchi.
Topics: Bronchial Diseases; Bronchiectasis; Humans; Mucus; Radiography; Tomography | 1966 |