Page last updated: 2024-10-28

guaifenesin and Asthma

guaifenesin has been researched along with Asthma in 705 studies

Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"This study evaluated substance P and neurokinin 1 protein expression and mucus content in endobronchial biopsy specimens from normal control subjects and asthmatic subjects."9.09Substance P and its receptor neurokinin 1 expression in asthmatic airways. ( Chu, HW; Kraft, M; Krause, JE; Martin, RJ; Rex, MD, 2000)
" azedarach fruit extract (MAE) using high-performance liquid chromatography (HPLC) and explored the therapeutic effects of MAE on pulmonary inflammation and mucus hypersecretion using a murine model of ovalbumin (OVA) exposed asthma."8.84Melia azedarach L. reduces pulmonary inflammation and mucus hypersecretion on a murine model of ovalbumin exposed asthma. ( Kim, T; Kim, WI; Lee, IS; Lee, SJ; Pak, SW; Shin, IS; Yang, YG, 2024)
"Azelastine (4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-p hthalazinone hydrochloride), a novel long-acting antiasthmatic/antiallergic drug has been demonstrated to be effective in the treatment both of asthma and of allergic rhinitis."8.78Azelastine: a multifaceted drug for asthma therapy. ( Achterrath-Tuckermann, U; Minker, E; Paegelow, I; Schmidt, J; Szelenyi, I; Werner, H, 1991)
"In this study, we investigated whether 4-hydroxycinnamic acid (HA) has a palliative effect on asthmatic inflammatory responses using a mouse model of ovalbumin (OVA)-induced allergic asthma."7.964-Hydroxycinnamic acid suppresses airway inflammation and mucus hypersecretion in allergic asthma induced by ovalbumin challenge. ( Choi, SJ; Kim, JC; Kim, MS; Kim, SH; Kim, YH; Ko, JW; Kwon, HJ; Seo, CS; Shin, IS; Shin, NR, 2020)
" In this study, we explored the suppressive effects of SAC on allergic airway inflammation induced in an ovalbumin (OVA)-induced asthma mouse model."7.91S-Allyl cysteine reduces eosinophilic airway inflammation and mucus overproduction on ovalbumin-induced allergic asthma model. ( Kim, JC; Kim, JS; Kim, SH; Ko, JW; Kwon, HJ; Lee, IC; Shin, IS; Shin, NR, 2019)
"The purpose of this study is to explore the influence of ozone repeated short exposures on airway/lung inflammation, airway hyperresponsiveness (AHR) and airway hypersecretion in ovalbumin (OVA) sensitized/challenged asthmatic mouse model."7.88Effects of ozone repeated short exposures on the airway/lung inflammation, airway hyperresponsiveness and mucus production in a mouse model of ovalbumin-induced asthma. ( Bao, A; Bao, W; Fei, X; Zhang, M; Zhang, X; Zhang, Y; Zhou, X, 2018)
" This study aimed to evaluate the preventive activity of IMP in an ovalbumin (OVA)-induced murine model of asthma and to investigate its possible molecular mechanisms."7.85Isoimperatorin attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma. ( Kwon, HJ; Moon, OS; Park, HS; Seo, CS; Son, HY; Song, JW; Wijerathne, CUB; Won, YS, 2017)
" In the current study, an ovalbumin (OVA)‑induced allergic asthma model was used to investigate the immune‑modulating effects of pidotimod on airway eosinophilia, mucus metaplasia and inflammatory factor expression compared with dexamethasone (positive control)."7.85Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma. ( Fu, AK; Fu, LQ; Hu, SL; Li, WF; Li, YL; Wang, YY; Wu, YP, 2017)
" argyi (TOTAL) and dehydromatricarin A (DA), its active component on ovalbumin (OVA)-induced allergic asthma."7.85Artemisia argyi attenuates airway inflammation in ovalbumin-induced asthmatic animals. ( Jeong, SH; Kim, HJ; Kim, JC; Ko, JW; Park, SH; Ryu, HW; Shin, IS; Shin, NR; Yuk, HJ, 2017)
"Repeated inhalation of sevoflurane (SVF) can benefit asthmatic patients by bronchodilation."7.81Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation. ( Ding, PS; Fang, L; He, F; Liu, RY; Shen, QY; Wu, HM, 2015)
"We have reported that triptolide inhibited pulmonary inflammation in patients with steroid-resistant asthma."7.81Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-κB in a murine model of asthma. ( Chen, M; Huang, L; Jiang, S; Liang, R; Lin, X; Lv, Z; Shi, J; Zhang, W, 2015)
"We used ovalbumin (OVA)-based mouse models of asthma and primary CD4(+) T cells."7.81PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function. ( Al-Ghareeb, K; Al-Khami, AA; Boulares, AH; El-Bahrawy, AH; Ghonim, MA; Ibba, SV; Lammi, MR; Mansy, MS; Naura, AS; Ochoa, A; Pyakurel, K; Rady, HF; Ramsay, A; Rodriguez, P; Wang, J, 2015)
"To explore the impact of ozone on the airway hyperresponsinveness (AHR), airway inflammation and mucus production in an allergic asthma mouse model."7.81[Effects of ozone oxidative stress on the airway hyperresponsiveness and mucus production in mice with acute allergic airway inflammation]. ( Aihua, B; Feng, L; Xin, Z; Yuqing, C; Zhang, M, 2015)
"The flavonoid naringenin has been shown to attenuate airway inflammation and airway hyper‑reactivity in acute murine models of asthma."7.80Naringenin inhibits allergen‑induced airway remodeling in a murine model of asthma. ( Gu, W; Mao, S; Shi, Y; Tan, Y, 2014)
" In this study, we evaluated the protective effects of EBM84 on asthmatic responses, particularly mucus hypersecretion in an ovalbumin (OVA)-induced murine model of asthma."7.79EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma. ( Ha, H; Jeon, WY; Lee, MY; Seo, CS; Shin, IS; Shin, NR, 2013)
"We investigated the suitability of dendritic polyglycerol sulfates (dPGS), conjugated with a hydrophilic version of the indocyanine green label with 6 sulfonate groups (6S-ICG) to monitor sites of inflammation using an experimental mouse model of allergic asthma."7.79Dendritic polyglycerolsulfate near infrared fluorescent (NIRF) dye conjugate for non-invasively monitoring of inflammation in an allergic asthma mouse model. ( Alves, F; Biffi, S; Bosnjak, B; Dal Monego, S; Dullin, C; Epstein, MM; Garrovo, C; Licha, K; Welker, P, 2013)
" In this study, we intend to explore the role of PAR-1 in the process of thrombin-inducing transforming growth factor-β1 (TGF-β1) to promote airway remodeling in ovalbumin (OVA)-allergic rats."7.79Thrombin promotes airway remodeling via protease-activated receptor-1 and transforming growth factor-β1 in ovalbumin-allergic rats. ( Bi, M; Guo, A; Liu, Y; Lv, H; Pan, F; Qiu, L; Wang, P; Wang, Y; Yao, P; Zhang, N; Zhu, W, 2013)
"Montelukast, a leukotriene receptor antagonist, is used commercially as a maintenance treatment for asthma and to relieve allergic symptoms."7.79Effects of montelukast on subepithelial/peribronchial fibrosis in a murine model of ovalbumin induced chronic asthma. ( Jeon, WY; Lee, MY; Shin, HK; Shin, IS, 2013)
"Verapamil is a useful drug with therapeutic targeting on GCH and a potential way to limit mucous production and improve bronchial inflammation."7.78Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals. ( Ghafarzadegan, K; Hadi, R; Khakzad, MR; Meshkat, M; Mirsadraee, M; Mohammadpour, A; Saghari, M, 2012)
" Female BALB/c mice sensitized and challenged with ovalbumin developed airway inflammation."7.78Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB. ( Cheng, C; Goh, FY; Guan, S; Leung, BP; Sethi, G; Shanmugam, MK; Upton, N; Wong, WS, 2012)
"Evidence suggests that nebulized lidocaine is beneficial in asthma therapy, but to what extent and the mechanisms underlying this effect remain poorly understood."7.78Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma. ( Anjos-Valotta, EA; Arantes, AC; Cordeiro, RS; Cotias, AC; Couto, GC; Ferreira, TP; Jurgilas, PB; Martins, MA; Olsen, PC; Pão, CR; Pires, AL; Serra, MF; Silva, PM, 2012)
"Altered arginine metabolism, the uncoupling of nitric oxide synthase (NOS) by asymmetric dimethyl-arginine (ADMA), increased oxo-nitrosative stress, and cellular injury were reported in airway epithelial cells in asthma."7.77Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. ( Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A, 2011)
"The purposes of this study were to determine whether curcumin inhibits NF-κB-dependent transcription in vitro, and test whether treatment with curcumin reduces allergen-induced airway inflammation and hyper-responsiveness in a mouse model of asthma through inhibition of NF-κB pathway."7.77Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-κB inhibition. ( Cha, JY; Chang, BC; Jung, JE; Kim, DY; Kwon, HJ; Lee, BR; Oh, SW, 2011)
" This study aimed to evaluate the therapeutic availability of kefiran on the ovalbumin-induced asthma mouse model in which airway inflammation and airway hyper-responsiveness were found in the lung."7.74Inhibitory effect of kefiran on ovalbumin-induced lung inflammation in a murine model of asthma. ( Ahn, KS; Kim, MK; Kim, SY; Kwon, OK; Lee, HK; Lee, IY; Lee, MY; Oh, SR; Park, BY, 2008)
"Sputum was collected from 12 asthmatics (26-73 year), lifelong non-smokers, at baseline, after eformoterol (24 mug) and after mannitol on each of four visits."7.74Inhaled mannitol changes the sputum properties in asthmatics with mucus hypersecretion. ( Anderson, SD; Daviskas, E; Young, IH, 2007)
"(R)- and (S)-Enantiomers of albuterol likely exert differential effects in patients with asthma."7.73Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model. ( Banerjee, ER; Chi, EY; Henderson, WR, 2005)
"The effects of niflumic acid (NA), a relatively specific blocker of calcium-activated chloride channel (CLCA), on goblet cell hyperplasia, eosinophil accumulation, and airway hyperresponsiveness were evaluated after IL-13 instillation into the airways."7.73Niflumic acid suppresses interleukin-13-induced asthma phenotypes. ( Aizawa, H; Fukuyama, S; Inoue, H; Matsumoto, K; Matsumoto, T; Matsumura, M; Nakanishi, Y; Nakano, T; Tsuda, M, 2006)
" As the lipoxygenase pathway is the only operant metabolic system available for arachidonic acid in the presence of aspirin and non-steroidal anti-inflammatory drugs--and as the nonsteroidal anti-inflammatory drugs themselves stimulate mucus production--it is possible that the mechanism responsible for mucus release in aspirin-sensitive asthmatics is the formation of these lipoxygenase products."7.66Possible mechanisms underlying mucus secretion in aspirin-sensitive asthma. ( Kaliner, M; Marom, Z, 1983)
"Three patients suffering from severe, chronic, bronchial asthma underwent bronchoscopy and lavage, using in the irrigant fluid acetylcysteine, isoetharine and Solu-Medrol."7.66Status Asthmaticus: use of acetylcysteine during bronchoscopy and lavage to remove mucous plugs. ( Goldstein, IM; Goodman, AH; Millman, FM; Millman, M; Van Campen, SS, 1983)
"Allergic asthma is a chronic respiratory disease caused by an inappropriate immune response."5.72Gekko gecko extract attenuates airway inflammation and mucus hypersecretion in a murine model of ovalbumin-induced asthma. ( Kim, JS; Lee, JH; Lee, S; Moon, BC; Nam, HH; Noh, P; Ryu, SM; Seo, YS; Yang, S, 2022)
"Ovalbumin (OVA) was used as a stimulant to sensitize BALB/c mice to establish an asthmatic model."5.62Ding Chuan Tang Attenuates Airway Inflammation and Eosinophil Infiltration in Ovalbumin-Sensitized Asthmatic Mice. ( Chen, LC; Kuo, ML; Liu, MX; Ma, J; Shen, JJ, 2021)
"Cordycepin (Cor), which is a naturally occurring nucleoside derivative isolated from Cordyceps militaris, has been shown to exert excellent antiinflammatory activity in a murine model of acute lung injury."5.42Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process. ( Deng, Y; He, Y; Li, T; Li, Y; Lin, R; Wang, W; Wei, J; Yang, X; Zhang, J, 2015)
"Melatonin was administered by intraperitoneal injection once per day at doses of 10 and 15 mg/kg from days 21 to 23 after the initial OVA sensitization."5.40Melatonin reduces airway inflammation in ovalbumin-induced asthma. ( Ahn, KS; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2014)
"Allantoin treatment led to significant reduction in the levels of Ig(immunoglobulin)E and T-helper-2-type cytokines, such as IL(interleukin)-4 and IL-5, in bronchoalveolar lavage (BAL) fluid."5.36Protective effects of allantoin against ovalbumin (OVA)-induced lung inflammation in a murine model of asthma. ( Jung, D; Kim, JH; Lee, H; Lee, JA; Lee, MY; Lee, NH; Seo, CS; Shin, HK, 2010)
"This study evaluated substance P and neurokinin 1 protein expression and mucus content in endobronchial biopsy specimens from normal control subjects and asthmatic subjects."5.09Substance P and its receptor neurokinin 1 expression in asthmatic airways. ( Chu, HW; Kraft, M; Krause, JE; Martin, RJ; Rex, MD, 2000)
"Ovalbumin (OVA) and BaP co-exposure were used to establish the aggravated asthma model."4.84Qufeng Xuanbi Formula inhibited benzo[a]pyrene-induced aggravated asthma airway mucus secretion by AhR/ROS/ERK pathway. ( Hu, J; Liu, CY; Liu, L; Shi, XL; Sun, XH; Tang, LL; Wang, BH; Wang, Y; Yang, Y; Yu, KY; Zhang, Q; Zhang, XN, 2024)
" azedarach fruit extract (MAE) using high-performance liquid chromatography (HPLC) and explored the therapeutic effects of MAE on pulmonary inflammation and mucus hypersecretion using a murine model of ovalbumin (OVA) exposed asthma."4.84Melia azedarach L. reduces pulmonary inflammation and mucus hypersecretion on a murine model of ovalbumin exposed asthma. ( Kim, T; Kim, WI; Lee, IS; Lee, SJ; Pak, SW; Shin, IS; Yang, YG, 2024)
"Azelastine (4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-p hthalazinone hydrochloride), a novel long-acting antiasthmatic/antiallergic drug has been demonstrated to be effective in the treatment both of asthma and of allergic rhinitis."4.78Azelastine: a multifaceted drug for asthma therapy. ( Achterrath-Tuckermann, U; Minker, E; Paegelow, I; Schmidt, J; Szelenyi, I; Werner, H, 1991)
" It seems likely that this eicosanoid-mucus secretion relationship is very important in all forms of asthma, but most particularly in aspirin-related asthma."4.77The role of eicosanoids in respiratory mucus hypersecretion. ( Kaliner, MA; Lundgren, JD; Shelhamer, JH, 1985)
"Ovalbumin (OVA) and cold water-induced cold asthma model were established in male mice."4.12Processed product (Pinelliae Rhizoma Praeparatum) of Pinellia ternata (Thunb.) Breit. Alleviates the allergic airway inflammation of cold phlegm via regulation of PKC/EGFR/MAPK/PI3K-AKT signaling pathway. ( Chen, S; Cheng, Y; Li, J; Liu, H; Tao, X; Wang, C; Wang, H; Wu, H; Xia, J; Xie, Y; Yu, H; Zeng, P; Zhang, P; Zhang, X, 2022)
"We established ovalbumin (OVA) induced asthmatic murine model and orally administrated Iristectorigenin A at concentration of 5 and 10 mg/kg and dexamethasone as a positive control substance."4.12Iristectorigenin A exerts novel protective properties against airway inflammation and mucus hypersecretion in OVA-induced asthmatic mice: Iristectorigenin A ameliorates asthma phenotype. ( Abduwaki, M; Cui, J; Dong, JC; Luo, Q; Lv, Y; Nabijan, M; Nurahmat, M; Qin, J; Tang, W; Teng, F; Wang, S; Wei, Y; Wuniqiemu, T; Zhou, Y; Zhu, X, 2022)
" An ovalbumin (OVA)-induced mouse asthma model was established and the effect of acupuncture on airway hyperresponsiveness (AHR), mucus hypersecretion and inflammation was assessed."4.02TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model. ( Cui, J; Dong, J; Dong, M; Qin, J; Tang, W; Teng, F; Wang, S; Wang, W; Wei, Y; Wuniqiemu, T; Zhu, X, 2021)
"In this study, we investigated whether 4-hydroxycinnamic acid (HA) has a palliative effect on asthmatic inflammatory responses using a mouse model of ovalbumin (OVA)-induced allergic asthma."3.964-Hydroxycinnamic acid suppresses airway inflammation and mucus hypersecretion in allergic asthma induced by ovalbumin challenge. ( Choi, SJ; Kim, JC; Kim, MS; Kim, SH; Kim, YH; Ko, JW; Kwon, HJ; Seo, CS; Shin, IS; Shin, NR, 2020)
"Fifty rats (25 males and 25 females) were divided randomly into the control group, ovalbumin asthmatic model group, asthma low-, middle- and high-dose groups (n = 10, 5 males and 5 females each group)."3.96Effect of NF-κB signal pathway on mucus secretion induced by atmospheric PM ( Liu, Y; Peng, L; Wang, H; Zhang, B; Zhang, T; Zhou, L, 2020)
"In vivo, mice were sensitized and challenged by ovalbumin (OVA) to induce asthma."3.96Monocyte chemotactic protein-inducing protein 1 negatively regulating asthmatic airway inflammation and mucus hypersecretion involving γ-aminobutyric acid type A receptor signaling pathway in vivo and in vitro. ( Chen, ZH; Dai, GM; Deng, HJ; Mao, RL; Ran, YJ; Wang, JJ; Zhu, T, 2020)
" In this study, we explored the suppressive effects of SAC on allergic airway inflammation induced in an ovalbumin (OVA)-induced asthma mouse model."3.91S-Allyl cysteine reduces eosinophilic airway inflammation and mucus overproduction on ovalbumin-induced allergic asthma model. ( Kim, JC; Kim, JS; Kim, SH; Ko, JW; Kwon, HJ; Lee, IC; Shin, IS; Shin, NR, 2019)
"The purpose of this study is to explore the influence of ozone repeated short exposures on airway/lung inflammation, airway hyperresponsiveness (AHR) and airway hypersecretion in ovalbumin (OVA) sensitized/challenged asthmatic mouse model."3.88Effects of ozone repeated short exposures on the airway/lung inflammation, airway hyperresponsiveness and mucus production in a mouse model of ovalbumin-induced asthma. ( Bao, A; Bao, W; Fei, X; Zhang, M; Zhang, X; Zhang, Y; Zhou, X, 2018)
"NK may be an effective alternative therapeutic option in patients with CRSwNP and comorbid asthma by causing fibrin degradation."3.85Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus. ( Fujieda, S; Imoto, Y; Ishizuka, T; Kato, Y; Narita, N; Sakashita, M; Takabayashi, T; Tokunaga, T; Yoshida, K, 2017)
" This study aimed to evaluate the preventive activity of IMP in an ovalbumin (OVA)-induced murine model of asthma and to investigate its possible molecular mechanisms."3.85Isoimperatorin attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma. ( Kwon, HJ; Moon, OS; Park, HS; Seo, CS; Son, HY; Song, JW; Wijerathne, CUB; Won, YS, 2017)
" This study evaluates whether intranasally delivered gas-filled microbubble (MB)-associated ovalbumin (OVA), used as a model allergen, can serve as a therapeutic treatment in a mouse model of established allergic asthma."3.85Therapeutic intranasal instillation of allergen-loaded microbubbles suppresses experimental allergic asthma in mice. ( Bioley, G; Corthésy, B, 2017)
" In the current study, an ovalbumin (OVA)‑induced allergic asthma model was used to investigate the immune‑modulating effects of pidotimod on airway eosinophilia, mucus metaplasia and inflammatory factor expression compared with dexamethasone (positive control)."3.85Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma. ( Fu, AK; Fu, LQ; Hu, SL; Li, WF; Li, YL; Wang, YY; Wu, YP, 2017)
" argyi (TOTAL) and dehydromatricarin A (DA), its active component on ovalbumin (OVA)-induced allergic asthma."3.85Artemisia argyi attenuates airway inflammation in ovalbumin-induced asthmatic animals. ( Jeong, SH; Kim, HJ; Kim, JC; Ko, JW; Park, SH; Ryu, HW; Shin, IS; Shin, NR; Yuk, HJ, 2017)
"We sought to determine the effect of Ptx3 deletion on ovalbumin (OVA)-induced allergic inflammation in a murine model of asthma."3.85Pentraxin 3 deletion aggravates allergic inflammation through a T ( Almiski, MS; Balhara, J; Doeing, D; Gounni, AS; Halayko, AJ; Matzuk, MM; McConville, J; Muhuri, A; Shan, L; Zhang, J, 2017)
" PRE treatment decreased mucus production in airway epithelium, inflammatory cell number, eosinophilia, type 2 cytokines, and histamine in bronchoalveolar lavage fluid (BALF)."3.85Reduced allergic lung inflammation by root extracts from two species of Peucedanum through inhibition of Th2 cell activation. ( Chun, JM; Gu, GJ; Kim, HS; Kwon, BI; Lee, AR; Lee, AY, 2017)
" In addition, to investigate the effects of CuONPs on asthma development, we used a murine model of ovalbumin (OVA)-induced asthma."3.83Copper oxide nanoparticles aggravate airway inflammation and mucus production in asthmatic mice via MAPK signaling. ( Ahn, KS; Jeon, CM; Kim, JC; Ko, JW; Kwon, OK; Lee, IC; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2016)
" This study aimed to determine the possible effects and underlying mechanisms of Suhuang on chronic ovalbumin (OVA)-induced airway hyperresponsiveness (AHR), inflammation, and remodeling in mice."3.83Suhuang antitussive capsule at lower doses attenuates airway hyperresponsiveness, inflammation, and remodeling in a murine model of chronic asthma. ( Che, LQ; Chen, ZH; Lai, TW; Li, W; Shen, HH; Wang, HS; Wu, YF; Xiao, H; Ying, SM; Zhang, C; Zhang, LH, 2016)
"Repeated inhalation of sevoflurane (SVF) can benefit asthmatic patients by bronchodilation."3.81Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation. ( Ding, PS; Fang, L; He, F; Liu, RY; Shen, QY; Wu, HM, 2015)
"We have reported that triptolide inhibited pulmonary inflammation in patients with steroid-resistant asthma."3.81Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-κB in a murine model of asthma. ( Chen, M; Huang, L; Jiang, S; Liang, R; Lin, X; Lv, Z; Shi, J; Zhang, W, 2015)
"We used ovalbumin (OVA)-based mouse models of asthma and primary CD4(+) T cells."3.81PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function. ( Al-Ghareeb, K; Al-Khami, AA; Boulares, AH; El-Bahrawy, AH; Ghonim, MA; Ibba, SV; Lammi, MR; Mansy, MS; Naura, AS; Ochoa, A; Pyakurel, K; Rady, HF; Ramsay, A; Rodriguez, P; Wang, J, 2015)
"To explore the impact of ozone on the airway hyperresponsinveness (AHR), airway inflammation and mucus production in an allergic asthma mouse model."3.81[Effects of ozone oxidative stress on the airway hyperresponsiveness and mucus production in mice with acute allergic airway inflammation]. ( Aihua, B; Feng, L; Xin, Z; Yuqing, C; Zhang, M, 2015)
"The flavonoid naringenin has been shown to attenuate airway inflammation and airway hyper‑reactivity in acute murine models of asthma."3.80Naringenin inhibits allergen‑induced airway remodeling in a murine model of asthma. ( Gu, W; Mao, S; Shi, Y; Tan, Y, 2014)
" In this study, we investigated the protective effects of SG extract on allergic asthma in an ovalbumin (OVA)-induced asthma murine model and lipopolysaccharide (LPS)-stimulated RAW264."3.80Siegesbeckia glabrescens attenuates allergic airway inflammation in LPS-stimulated RAW 264.7 cells and OVA induced asthma murine model. ( Ahn, KS; Hong, JM; Jeon, CM; Kim, HS; Kwon, OK; Myung, PK; Oh, SR; Shin, IS; Shin, NR, 2014)
" In this study, we evaluated the protective effects of EBM84 on asthmatic responses, particularly mucus hypersecretion in an ovalbumin (OVA)-induced murine model of asthma."3.79EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma. ( Ha, H; Jeon, WY; Lee, MY; Seo, CS; Shin, IS; Shin, NR, 2013)
"We investigated the suitability of dendritic polyglycerol sulfates (dPGS), conjugated with a hydrophilic version of the indocyanine green label with 6 sulfonate groups (6S-ICG) to monitor sites of inflammation using an experimental mouse model of allergic asthma."3.79Dendritic polyglycerolsulfate near infrared fluorescent (NIRF) dye conjugate for non-invasively monitoring of inflammation in an allergic asthma mouse model. ( Alves, F; Biffi, S; Bosnjak, B; Dal Monego, S; Dullin, C; Epstein, MM; Garrovo, C; Licha, K; Welker, P, 2013)
"In the OVA-exposed mice for 6 wks inflammatory cells infiltration, levels of inflammatory cytokines and chemokines, goblet cell metaplasia, collagen deposition and AHR were significantly decreased by treatment with AR inhibitor, fidarestat."3.79Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice. ( Aguilera-Aguirre, L; Boldogh, I; Boulares, HA; Calhoun, WJ; Naura, AS; Ramana, KV; Srivastava, SK; Yadav, UC, 2013)
" In this study, we intend to explore the role of PAR-1 in the process of thrombin-inducing transforming growth factor-β1 (TGF-β1) to promote airway remodeling in ovalbumin (OVA)-allergic rats."3.79Thrombin promotes airway remodeling via protease-activated receptor-1 and transforming growth factor-β1 in ovalbumin-allergic rats. ( Bi, M; Guo, A; Liu, Y; Lv, H; Pan, F; Qiu, L; Wang, P; Wang, Y; Yao, P; Zhang, N; Zhu, W, 2013)
"Montelukast, a leukotriene receptor antagonist, is used commercially as a maintenance treatment for asthma and to relieve allergic symptoms."3.79Effects of montelukast on subepithelial/peribronchial fibrosis in a murine model of ovalbumin induced chronic asthma. ( Jeon, WY; Lee, MY; Shin, HK; Shin, IS, 2013)
"Verapamil is a useful drug with therapeutic targeting on GCH and a potential way to limit mucous production and improve bronchial inflammation."3.78Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals. ( Ghafarzadegan, K; Hadi, R; Khakzad, MR; Meshkat, M; Mirsadraee, M; Mohammadpour, A; Saghari, M, 2012)
" Female BALB/c mice sensitized and challenged with ovalbumin developed airway inflammation."3.78Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB. ( Cheng, C; Goh, FY; Guan, S; Leung, BP; Sethi, G; Shanmugam, MK; Upton, N; Wong, WS, 2012)
"Evidence suggests that nebulized lidocaine is beneficial in asthma therapy, but to what extent and the mechanisms underlying this effect remain poorly understood."3.78Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma. ( Anjos-Valotta, EA; Arantes, AC; Cordeiro, RS; Cotias, AC; Couto, GC; Ferreira, TP; Jurgilas, PB; Martins, MA; Olsen, PC; Pão, CR; Pires, AL; Serra, MF; Silva, PM, 2012)
"Altered arginine metabolism, the uncoupling of nitric oxide synthase (NOS) by asymmetric dimethyl-arginine (ADMA), increased oxo-nitrosative stress, and cellular injury were reported in airway epithelial cells in asthma."3.77Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma. ( Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A, 2011)
"In the present study, we investigated whether the Lagerstroemia indica Linn (LI) extract has an anti-inflammatory effect on lung inflammation in ovalbumin-induced asthmatic mice."3.77Anti-inflammatory effects of ethanolic extract from Lagerstroemia indica on airway inflammation in mice. ( Kim, DH; Kim, IS; Lee, JS; Song, BB; Yang, EJ; Yun, CY, 2011)
"The purposes of this study were to determine whether curcumin inhibits NF-κB-dependent transcription in vitro, and test whether treatment with curcumin reduces allergen-induced airway inflammation and hyper-responsiveness in a mouse model of asthma through inhibition of NF-κB pathway."3.77Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-κB inhibition. ( Cha, JY; Chang, BC; Jung, JE; Kim, DY; Kwon, HJ; Lee, BR; Oh, SW, 2011)
" Becker (VM) ethanolic (EtOH) extract in the treatment of bronchial asthma in an ovalbumin (OVA)-induced asthmatic BALB/c mouse model."3.76Anti-inflammatory and anti-asthmatic effects of Viola mandshurica W. Becker (VM) ethanolic (EtOH) extract on airway inflammation in a mouse model of allergic asthma. ( Ahn, KS; Kim, HS; Kwon, OK; Lee, HK; Lee, MY; Oh, SR; Yuk, JE, 2010)
"The effect of PET was investigated in ovalbumin (OVA) immunized BALB/c mice given intranasally together with antigen challenge in the murine model of allergic airway disease (asthma) with the analysis of the inflammatory and immune parameters in the lung."3.76Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice. ( Brattström, A; Maillet, I; Moser, R; Ryffel, B; Schapowal, A; Schnyder, B, 2010)
" The data showed that chronic SJ infection suppressed airway eosinophilia, mucus production and antigen-specific IgE responses induced by ovalbumin (OVA) sensitization and challenge."3.76Helminth infection inhibits airway allergic reaction and dendritic cells are involved in the modulation process. ( An, G; Gao, W; Ji, W; Li, J; Liu, P; Liu, X; Shen, Y; Wang, S; Wu, Z; Yang, X; Zhu, Y, 2010)
"ITE obtained from leaves by supercritical carbon dioxide extraction was investigated in ovalbumin (OVA) immunised BALB/c mice given intranasally together with antigen challenge in the murine model of allergic airway disease (asthma) with the analysis of the inflammatory and immune parameters in the lung."3.76The plant extract Isatis tinctoria L. extract (ITE) inhibits allergen-induced airway inflammation and hyperreactivity in mice. ( Brattström, A; Kamal, MA; Maillet, I; Moser, R; Ryffel, B; Schapowal, A, 2010)
"Theophylline can increase the transepithelial secretion of fluid into the respiratory tract lumen by stimulating the chloride pump which is controlled by cyclic AMP."3.76Theophylline and mucociliary clearance. ( Ziment, I, 1987)
") inhibited the number of coughs induced by capsaicin aerosol (P<0."3.74Novel triple neurokinin receptor antagonist CS-003 inhibits respiratory disease models in guinea pigs. ( Kuraya, T; Morimoto, K; Nosaka, E; Takahashi, S; Tsuchida, H; Yamashita, M, 2008)
" This study aimed to evaluate the therapeutic availability of kefiran on the ovalbumin-induced asthma mouse model in which airway inflammation and airway hyper-responsiveness were found in the lung."3.74Inhibitory effect of kefiran on ovalbumin-induced lung inflammation in a murine model of asthma. ( Ahn, KS; Kim, MK; Kim, SY; Kwon, OK; Lee, HK; Lee, IY; Lee, MY; Oh, SR; Park, BY, 2008)
" The expression of GAD in the cytosol and GABAARs in the apical membranes of airway epithelial cells increased markedly when mice were sensitized and then challenged with ovalbumin, an approach for inducing allergic asthmatic reactions."3.74A GABAergic system in airway epithelium is essential for mucus overproduction in asthma. ( Fan, Y; Hirota, JA; Inman, MD; Ju, W; Kelly, MM; Li, J; Liu, M; Lu, WY; O'Byrne, PM; Orser, B; Wang, S; Xiang, YY; Yang, X; Ye, B, 2007)
" In order to investigate the pharmacological effects of kefir, we used a mouse asthma model, in which airway inflammation and airway remodeling was produced by ovalbumin sensitization and challenge."3.74Anti-inflammatory and anti-allergic effects of kefir in a mouse asthma model. ( Ahn, KS; Kim, MJ; Kim, MK; Kwon, OK; Lee, HK; Lee, IY; Lee, MY; Oh, SR, 2007)
"Sputum was collected from 12 asthmatics (26-73 year), lifelong non-smokers, at baseline, after eformoterol (24 mug) and after mannitol on each of four visits."3.74Inhaled mannitol changes the sputum properties in asthmatics with mucus hypersecretion. ( Anderson, SD; Daviskas, E; Young, IH, 2007)
"(R)- and (S)-Enantiomers of albuterol likely exert differential effects in patients with asthma."3.73Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model. ( Banerjee, ER; Chi, EY; Henderson, WR, 2005)
"The effects of niflumic acid (NA), a relatively specific blocker of calcium-activated chloride channel (CLCA), on goblet cell hyperplasia, eosinophil accumulation, and airway hyperresponsiveness were evaluated after IL-13 instillation into the airways."3.73Niflumic acid suppresses interleukin-13-induced asthma phenotypes. ( Aizawa, H; Fukuyama, S; Inoue, H; Matsumoto, K; Matsumoto, T; Matsumura, M; Nakanishi, Y; Nakano, T; Tsuda, M, 2006)
"An asthma model was sensitized and challenged by ovalbumin (OVA) in male C57BL/6 mice."3.73CCR3 monoclonal antibody inhibits airway eosinophilic inflammation and mucus overproduction in a mouse model of asthma. ( Shen, HH; Wang, SB; Xu, F; Xu, WH; Zhang, GS, 2006)
"Twenty-four BALB/c mice were randomly divided into 3 equal groups: asthma group [ovalbumin (OVA) and aluminum hydroxide were injected intraperitoneally on day 0 and day 14 so as to establish mouse asthma model and aerosol inhalation of OVA PBS was conducted for 30 min on the days 21, 22, and 24], asthma + dexamethasone group (OVA and aluminum hydroxide were injected intraperitoneally on days 0 and 14, aerosol inhalation of OVA PBS was conducted for 30 min on the days 21, 22, and 24, and dexamethasone was injected intraperitoneally 1 hour before the aerosol inhalation), and control group (aerosol inhalation of PBS was conducted instead)."3.73[Effects of glucocorticoid on airway mucus secretion in asthma: experiment with asthmatic mouse model]. ( Liu, JB; Xing, LH; Xu, YJ; Zhang, HL; Zhang, ZX, 2006)
" To clarify the effects of DE on the exacerbation of asthma, guinea pigs were exposed 12 h daily to 3 mg/m(3) DE or air for 8 wk with or without sensitization to ovalbumin (OVA)."3.71Exposure to diesel exhaust exacerbates allergen-induced airway responses in guinea pigs. ( Hashimoto, K; Hirano, K; Ishii, Y; Kimura, T; Masuyama, K; Morishima, Y; Nomura, A; Sagai, M; Sakamoto, T; Sekizawa, K; Takano, H; Uchida, Y, 2001)
" To elucidate whether heparin affects goblet cell secretion in asthmatic airways and, if so, what the mechanism of action is, we studied guinea pigs sensitized with ovalbumin (OVA) by determining the mucus score (MS) of tracheal goblet cells stained with Alcian blue and PAS."3.70[Effect of heparin on airway goblet cell secretion in sensitized guinea pigs]. ( Kondo, M; Nagai, A; Nakata, J; Takeda, Y; Takeyama, K; Tamaoki, J; Yamawaki, I, 1998)
"The ovalbumin-sensitized guinea pig is commonly used as a small animal model of allergic asthma."3.69Effect of dexamethasone on antigen-induced high molecular weight glycoconjugate secretion in allergic guinea pigs. ( Boulet, L; Chan, CC; Plant, M; Pon, DJ; Rodger, IW; Savoie, C; van Staden, CJ; Zwikker, M, 1995)
"To determine whether markers of mucus secretion can be quantified in airway lining fluid from asthmatic and from healthy subjects, we measured levels of a mucin-like glycoprotein (MLG) and lactoferrin in sputum induced by inhalation of hypertonic (3%) saline in 18 asthmatic and in 10 healthy subjects."3.68Markers of mucus secretion and DNA levels in induced sputum from asthmatic and from healthy subjects. ( Basbaum, CB; Boushey, HA; Fahy, JV; Finkbeiner, WE; Liu, J; Steiger, DJ, 1993)
"Nasal mucociliary clearance was measured using a saccharin technique in 172 patients with perennial rhinitis (76 also had asthma) and in 121 patients with chronic infected rhinosinusitis (40 had asthma, 35 had bronchiectasis)."3.67Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease. ( Cole, PJ; Greenstone, MA; Mackay, IS; Stanley, PJ; Wilson, R, 1985)
" As the lipoxygenase pathway is the only operant metabolic system available for arachidonic acid in the presence of aspirin and non-steroidal anti-inflammatory drugs--and as the nonsteroidal anti-inflammatory drugs themselves stimulate mucus production--it is possible that the mechanism responsible for mucus release in aspirin-sensitive asthmatics is the formation of these lipoxygenase products."3.66Possible mechanisms underlying mucus secretion in aspirin-sensitive asthma. ( Kaliner, M; Marom, Z, 1983)
"Three patients suffering from severe, chronic, bronchial asthma underwent bronchoscopy and lavage, using in the irrigant fluid acetylcysteine, isoetharine and Solu-Medrol."3.66Status Asthmaticus: use of acetylcysteine during bronchoscopy and lavage to remove mucous plugs. ( Goldstein, IM; Goodman, AH; Millman, FM; Millman, M; Van Campen, SS, 1983)
"A 14-year-old boy with severe asthma was treated with prednisone and disodium cromoglycate with considerable subjective improvement, though there was persistent airways obstruction."3.65Sudden death in a young asthmatic. ( Batten, J; Gregg, I, 1969)
"Neutrophilic inflammation is believed to contribute to the airway obstruction and remodelling in equine asthma."2.90Randomised study of the immunomodulatory effects of azithromycin in severely asthmatic horses. ( Bédard, C; Hélie, P; Labrecque, O; Lavoie, JP; Mainguy-Seers, S; Vargas, A, 2019)
"Among these, COPD is more prominent worldwide."2.82Nanocarrier-based approaches to combat chronic obstructive pulmonary disease. ( Kumar, G; Pathak, K; Sharma, A; Virmani, R; Virmani, T, 2022)
"Chronic cough is a common problem of various etiologies."2.79The assessment and management of chronic cough in children according to the British Thoracic Society guidelines: descriptive, prospective, clinical trial. ( Asilsoy, S; Durmaz, C; Usta Guc, B, 2014)
"Allergic bronchial asthma is a chronic disease of the airways that is characterized by symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute episodes of broncho-obstruction."2.66More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis. ( Ehlers, JC; Frey, A; Lunding, LP; Weckmann, M; Wegmann, M; Zissler, UM, 2020)
"Asthma, chronic obstructive pulmonary disease, and cystic fibrosis are three chronic pulmonary diseases that affect an estimated 420 million individuals across the globe."2.58Epigenetics of Mucus Hypersecretion in Chronic Respiratory Diseases. ( Breitzig, MT; Kolliputi, N; Lockey, RF; Saco, TV, 2018)
"In asthma and chronic obstructive pulmonary disease (COPD), airway mucus hypersecretion contributes to impaired mucociliary clearance, mucostasis and, potentially, the development of mucus plugging of the airways."2.53Novel Therapies to Inhibit Mucus Synthesis and Secretion in Airway Hypersecretory Diseases. ( Ha, EV; Rogers, DF, 2016)
"The hallmark traits of chronic obstructive airway diseases are inflammation, airway constriction due to hyperreactivity and mucus overproduction."2.52CLCA1 and TMEM16A: the link towards a potential cure for airway diseases. ( Brett, TJ, 2015)
"The term phenotype in the field of COPD is defined as "a single or combination of disease attributes that describe differences between individuals with COPD as they relate to clinically meaningful outcomes"."2.48Clinical phenotypes of COPD: identification, definition and implications for guidelines. ( Calle, M; Miravitlles, M; Soler-Cataluña, JJ, 2012)
"Although cough is one of the defining symptoms of asthma, wheeze, chest tightness and breathlessness have generally received more attention."2.46Interrupting the cough reflex in asthma. ( Smith, JA, 2010)
"Chronic bronchitis is characterized by mucus hypersecretion."2.37The pathology of obstructive and inflammatory airway diseases. ( Reid, LM, 1986)
"Occasionally, segmental or subsegmental atelectasis develops, but in most series radiographically visible atelectasis is uncommon."2.37Clinical aspects of mucus and mucous plugging in asthma. ( Fanta, CH, 1985)
"IL-13 develops bronchial asthma by elevating bronchial hyperresponsiveness and enables production of immunoglobulin M (IgM) and IgE."1.72High throughput virtual screening strategy to develop a potential treatment for bronchial asthma by targeting interleukin 13 cytokine signaling. ( Jing, J; Ma, Q; Tong, H, 2022)
"Allergic asthma is a chronic respiratory disease caused by an inappropriate immune response."1.72Gekko gecko extract attenuates airway inflammation and mucus hypersecretion in a murine model of ovalbumin-induced asthma. ( Kim, JS; Lee, JH; Lee, S; Moon, BC; Nam, HH; Noh, P; Ryu, SM; Seo, YS; Yang, S, 2022)
"Ovalbumin (OVA) was used as a stimulant to sensitize BALB/c mice to establish an asthmatic model."1.62Ding Chuan Tang Attenuates Airway Inflammation and Eosinophil Infiltration in Ovalbumin-Sensitized Asthmatic Mice. ( Chen, LC; Kuo, ML; Liu, MX; Ma, J; Shen, JJ, 2021)
"Tectochrysin treatment reduced the level of IgE in plasma, the percentage of eosinophils in total white blood cells in peripheral blood, the total number of cells in BAL fluid, and eosinophil peroxidase activity in lung tissues."1.62Tectochrysin ameliorates murine allergic airway inflammation by suppressing Th2 response and oxidative stress. ( Fang, L; He, Z; Jiang, X; Wu, F; Xu, Z; Yan, Y; Yu, D; Yuan, X; Zhang, T; Zhou, S, 2021)
"The percentages of airway obstruction due to mucus plugs were notably higher in the fourth- and fifth-generation bronchi (17."1.56Changes in airway diameter and mucus plugs in patients with asthma exacerbation. ( Kurashima, K; Nakamoto, Y; Takaku, Y; Takayanagi, N; Takizawa, H; Yanagisawa, T; Yoshida, Y, 2020)
"Dithiothreitol and P3001 were directly compared with NAC in vitro and both exhibited superior reducing activities."1.51An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases. ( Boucher, RC; Delion, MF; Donaldson, SH; Ehre, C; Esther, CR; Fontana, NC; Grubb, BR; Hill, DB; Hothem, LN; Kato, T; Livraghi-Butrico, A; Markovetz, MR; Morrison, CB; Rushton, ZL; Thelin, WR; Villalon, D; Wang, B, 2019)
"Pneumocystis associates to more severe Chronic Obstructive Pulmonary Disease (COPD), asthma, respiratory distress of premature newborns, and is a consistent subclinical infection between 2 and 5 months of age when hospitalizations for respiratory cause and infant mortality are higher."1.51Increase in secreted airway mucins and partial Muc5b STAT6/FoxA2 regulation during Pneumocystis primary infection. ( Bórquez, P; Bustamante, R; Gallo, M; Iturra, PA; Méndez, A; Ponce, CA; Rojas, DA; Vargas, SL, 2019)
"Mucus plugs are a plausible mechanism of chronic airflow obstruction in severe asthma, and EPO-generated oxidants may mediate mucus plug formation."1.48Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. ( Bleecker, ER; Castro, M; Di Maio, S; Dunican, EM; Elicker, BM; Erzurum, SC; Fahy, JV; Fain, SB; Gierada, DS; Gordon, ED; Hoffman, EA; Israel, E; Jarjour, NN; Lachowicz-Scroggins, ME; Levy, BD; Mauger, DT; Meyers, DA; Nagle, SK; Newell, JD; Peters, MC; Phillips, BR; Raymond, WW; Schiebler, ML; Wenzel, SE; Woodruff, PG, 2018)
"Daily cough was recorded in 28."1.48Mucus hypersecretion in asthma is associated with rhinosinusitis, polyps and exacerbations. ( Crespo, A; García-Rivero, JL; López-Viña, A; Marina-Malanda, N; Martínez-Rivera, C; Mayoralas-Alises, S; Padilla, A; Pallarés-Sanmartín, A; Pascual-Erquicia, S; Picado, C; Pinedo-Sierra, C; Plaza, V, 2018)
"Casticin is an active compound that possesses broad biological activities including anti-inflammatory effect."1.48Casticin alleviates lipopolysaccharide-induced inflammatory responses and expression of mucus and extracellular matrix in human airway epithelial cells through Nrf2/Keap1 and NF-κB pathways. ( Wang, J, 2018)
"TAS2R agonists attenuated features of airway remodeling including smooth muscle mass, extracellular matrix deposition and pro-fibrotic signaling, and also prevented mucus accumulation and development of AHR in mice."1.46Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice. ( Deshpande, DA; Knight, MJ; Nayak, AP; Oliver, B; Pan, S; Sharma, P; Tang, F; Wang, N; Yi, R, 2017)
"①In 2014, the acute attacks of bronchial asthma were (1."1.46[Clinical therapeutic effect on bronchial asthma in children of different body constitutions treated with ( Deng, Y; Shi, Y; Tang, M; Wang, P; Yang, H; Zhang, L, 2017)
"Mice lacking the endogenous β2-adrenoceptor (β2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of β2AR agonists to PNMT-KO mice restores the phenotype."1.43Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice. ( Al-Sawalha, N; Bond, RA; Forkuo, GS; Gonnella, PA; Joshi, R; Kim, H; Knoll, BJ; Parra, S; Penn, RB; Pera, T; Thanawala, VJ; Valdez, D; Walker, JK, 2016)
"Cordycepin (Cor), which is a naturally occurring nucleoside derivative isolated from Cordyceps militaris, has been shown to exert excellent antiinflammatory activity in a murine model of acute lung injury."1.42Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process. ( Deng, Y; He, Y; Li, T; Li, Y; Lin, R; Wang, W; Wei, J; Yang, X; Zhang, J, 2015)
"We used a murine model of respiratory allergy to the mite Blomia tropicalis (Bt) and evaluated certain parameters known to be altered in this model."1.42The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. ( Alcântara-Neves, NM; Alves de Souza, S; da Silva Velozo, E; Ferreira Silva, HB; Figueiredo, CA; Meneses Souza, FL; Pires de Oliveira, A; Pontes-de-Carvalho, LC; Rios, R; Santos Alves, W; Santos Costa, R; Santos Serafim Machado, M; Sarmento Silva, TM; Silva, ML; Vilany Queiroz Carneiro, N, 2015)
"Sesamin is a natural polyphenolic compound with strong anti-oxidative effects."1.40Protective effects of the polyphenol sesamin on allergen-induced T(H)2 responses and airway inflammation in mice. ( Kao, ST; Lee, CC; Lin, CH; Shen, ML; Wu, DC; Zhou, N, 2014)
"Melatonin was administered by intraperitoneal injection once per day at doses of 10 and 15 mg/kg from days 21 to 23 after the initial OVA sensitization."1.40Melatonin reduces airway inflammation in ovalbumin-induced asthma. ( Ahn, KS; Jeon, CM; Kim, JC; Kim, JS; Kwon, OK; Oh, SR; Park, JW; Shin, IS; Shin, NR, 2014)
"Additionally, acute respiratory infections did not affect the microbiological colonization in asthmatics' airways (P = 0."1.40No direct association between asthma and the microbiome based on currently available techniques. ( Yayan, J, 2014)
"Inflammation was assessed by the total and differential cell counts and IL-4 and IL-5 levels in bronchoalveolar lavage (BAL) fluid."1.38The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma. ( Daubeuf, F; Frossard, N; Nemska, S; Reber, LL, 2012)
"Allantoin treatment led to significant reduction in the levels of Ig(immunoglobulin)E and T-helper-2-type cytokines, such as IL(interleukin)-4 and IL-5, in bronchoalveolar lavage (BAL) fluid."1.36Protective effects of allantoin against ovalbumin (OVA)-induced lung inflammation in a murine model of asthma. ( Jung, D; Kim, JH; Lee, H; Lee, JA; Lee, MY; Lee, NH; Seo, CS; Shin, HK, 2010)
" Smoking and asthma were risk factors for CMH, with a dose-response effect of tobacco consumption, and smoking habits also predicting incidence of CMH."1.36Chronic mucus hypersecretion: prevalence and risk factors in younger individuals. ( Backer, V; Harmsen, L; Ingebrigtsen, T; Kyvik, KO; Skadhauge, LR; Steffensen, IE; Thomsen, SF, 2010)
"In both asthma and COPD mouse models, pendrin was up-regulated at the apical side of airway epithelial cells in association with mucus overproduction."1.35Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease. ( Aizawa, H; Arima, K; Fukuda, T; Green, ED; Hasegawa, M; Hayashi, H; Hoshino, T; Inoue, H; Inoue, M; Izuhara, K; Kanaji, S; Kubo, H; Matsushita, H; Nagai, H; Nakao, I; Nakayama, K; Ohta, S; Okinami, S; Sagara, H; Shiraki, A; Sugiyama, K; Suzuki, K; Tanaka, H; Toda, S; Watanabe, M; Yamaya, M; Yuyama, N, 2008)
"To evaluate lung inflammation, mucus metaplasia and AHR in relationship with age in murine models of allergic asthma comparing young and older mice."1.34Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice. ( Busse, PJ; Li, XM; Schofield, B; Srivastava, K; Zhang, TF, 2007)
"Guaifenesin is a commonly used expectorant whose use may lead to the occasional formation of guaifenesin urinary stones."1.33Spontaneous dissolution of a guaifenesin stone. ( Fallon, B; Nguyen, TT; Winfield, HN, 2005)
" Inhalation of aerosolized p38alpha-ASO using an aerosol chamber dosing system produced measurable lung deposition of ASO and significant reduction of ovalbumin (OVA-)-induced increases in total cells, eosinophils, and interleukin 4 (IL-4), IL-5, and IL-13 levels in bronchoalveolar lavage fluid, and dose-dependent inhibition of airway hyperresponsiveness in allergen-challenged mice."1.33Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice. ( Chan, JH; Choo, HH; Crosby, JR; Duan, W; Karras, JG; Leung, BP; McKay, K; Wong, WS, 2005)
" In the present study, we have investigated the effect of a therapeutic dosing regimen with an anti-IL-13 monoclonal antibody (mAb) in a chronic mouse model of persistent asthma."1.33Therapeutic dosing with anti-interleukin-13 monoclonal antibody inhibits asthma progression in mice. ( Bugelski, PJ; Das, AM; Emmell, E; Giles-Komar, J; Griswold, DE; Lakshminarayanan, M; Li, L; Petley, T; Rafferty, P; Volk, A; Yang, G, 2005)
"Treatment was administered therapeutically, with dosing starting after the onset of established eosinophilic airway inflammation and hyper-reactivity."1.33Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling. ( Lloyd, CM; McMillan, SJ; Xanthou, G, 2005)
"Based on time from onset of symptoms to death, cases fell into two distinct groups: short course <3 (1."1.33Time to death, airway wall inflammation and remodelling in fatal asthma. ( Abramson, MJ; Elliot, JG; James, AL; Walters, EH, 2005)
"Airway eosinophilia was observed during both responses."1.33Effect of disodium cromoglycate on airway mucus secretion during antigen-induced late asthmatic responses in a murine model of asthma. ( Arakawa, H; Koyama, H; Mayuzumi, H; Mizuno, T; Mochizuki, H; Morikawa, A; Nishimura, H; Ohki, Y; Tokuyama, K, 2005)
"Human bronchial asthma is characterized by airway hyperresponsiveness (AHR), eosinophilic airway inflammation, mucus hypersecretion and high serum level of IgE."1.33Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness. ( Ishikawa, Y; Nakanishi, K; Yoshimoto, T, 2006)
"This is the first evidence that autoimmune diabetes-prone NOD mice can also give rise to enhanced Th2-mediated responses and might thus provide a useful model for the study of common genetic and cellular components, including NKT cells that contribute to both asthma and type 1 diabetes."1.32Exacerbated Th2-mediated airway inflammation and hyperresponsiveness in autoimmune diabetes-prone NOD mice: a critical role for CD1d-dependent NKT cells. ( Araujo, LM; Bach, JF; Diem, S; Dy, M; Herbelin, A; Lefort, J; Leite-de-Moraes, MC; Nahori, MA; Vargaftig, BB; Zhu, R, 2004)
"One hundred and two COPD patients and 183 controls, together with 46 asthma patients and 48 patients with chronic mucous hypersecretion (CMH) were examined."1.32Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland. ( Andrason, H; Gislason, T; Gulcher, JR; Hakonarson, H; Halapi, E; Jónasson, K; Laufs, J; Sigvaldason, A; Söebech, E; Stefansson, K; Thorsteinsson, L, 2004)
"These findings suggest that bronchial asthma with mucoid impactions is among several pathogeneses that cause increased levels of CEA in serum and BALF."1.32[Concentrations of carcinoembryonic antigen in serum and bronchoalveolar lavage fluid of asthmatic patients with mucoid impaction]. ( Fukui, Y; Harada, T; Hizawa, N; Kikuchi, E; Maeda, Y; Nagai, K; Nishimura, M; Suko, N; Takahashi, D, 2004)
"Plastic bronchitis was observed in 44 years old man, who expectorated white, branching, bronchial casts for three months."1.31[Plastic bronchitis and mucoid impaction--uncommon disease syndromes with expectoration mucus plugs]. ( Bestry, I; Pirozynski, M; Płodziszewska, M; Rowińska-Zakrzewska, E; Sledziewska, J; Wiatr, E; Załeska, J; Załeska, M, 2001)
"We encountered a patient with bronchial asthma and mucoid impaction who presented with a high concentration of carcinoembryonic antigen (CEA) in serum."1.30[A patient with bronchial asthma and mucoid impaction who presented with a high concentration of carcinoembryonic antigen in serum]. ( Araki, M; Hiraki, S; Matsuo, K; Watanabe, Y, 1997)
"Eosinophilia was abolished, yet mucus staining in the epithelium persisted."1.30Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. ( Bottomly, K; Brombacher, F; Cohn, L; Homer, RJ; MacLeod, H; Mohrs, M, 1999)
"These results show that in bronchial asthma patients, mucus hypersecretion is more often observed clinically in those with SDIA and in women, and that this hypersecretion is closely correlated with BAL eosinophilia, which is a feature of the pathophysiological changes that occur in the airways of these patients."1.29Mucus hypersecretion and eosinophils in bronchoalveolar lavage fluid in adult patients with bronchial asthma. ( Kimura, I; Kitani, H; Mifune, T; Mitsunobu, F; Okazaki, M; Tanizaki, Y, 1993)
"Fifty patients with bronchial asthma were divided into four groups according to the amount of expectoration per day: 0-24, 25-49, 50-99 and 100+ ml/day."1.29[Clinical features of bronchial asthma with mucus hypersecretion]. ( Kimura, I; Kitani, H; Mifune, T; Mitsunobu, F; Okazaki, M; Soda, R; Tada, S; Takahashi, K; Tanizaki, Y, 1993)
"Eosinophilia was associated with asthma and with phlegm production."1.28Asthma, hay fever, and phlegm production associated with distinct patterns of allergy skin test reactivity, eosinophilia, and serum IgE levels. The Normative Aging Study. ( O'Connor, GT; Sparrow, D; Tollerud, DJ; Weiss, ST, 1991)
"Cough was due to one condition in 73%, two in 23%, and three in 3%."1.28Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. ( Curley, FJ; French, CL; Irwin, RS, 1990)

Research

Studies (705)

TimeframeStudies, this research(%)All Research%
pre-1990211 (29.93)18.7374
1990's60 (8.51)18.2507
2000's171 (24.26)29.6817
2010's191 (27.09)24.3611
2020's72 (10.21)2.80

Authors

AuthorsStudies
Ma, Q1
Tong, H1
Jing, J1
Dhar, R1
SCHILLER, IW1
MICHELSON, AL1
FRIEDMAN, S1
KARLIN, H1
LEVY, DL1
UNGER, DL3
TOWNLEY, RG1
BRONSTEIN, SB1
LEVIN, SJ2
SCHERER, RA1
GHORY, JE1
BERNSTEIN, IL1
KREINDLER, L1
AUSDENMOORE, RW1
HEISEN, AJ1
HEISEN, A1
DAMRAU, F1
GROVER, FW1
WEISNAGEL, J1
Nguyen, TT1
Fallon, B1
Winfield, HN1
Unger, L2
Temple, DE2
Falliers, CJ1
Cato, AE1
Harris, JR1
Brandon, BM1
Stolley, PD1
West, SK1
Swartz, D1
Rumrill, R1
Heilborn, H1
Odeblad, E1
Kokkola, K1
Vaara, J1
Wójcicki, J1
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Geary, RS1
Monia, BP1
Gregory, SA1
McElwain, S1
Ferguson, P1
Fink, JB1
Paveglio, SA1
Allard, J1
Mayette, J1
Whittaker, LA1
Juncadella, I1
Anguita, J1
Poynter, ME1
Swaisgood, CM1
Aronica, MA1
Swaidani, S1
Plow, EF1
Bao, Z1
Lim, S1
Liao, W1
Thiemermann, C1
Xiang, YY1
Liu, M1
Hirota, JA1
Ju, W1
Fan, Y2
Kelly, MM1
Ye, B1
Orser, B1
O'Byrne, PM1
Corry, DB2
Kheradmand, F2
McCusker, CT1
Shan, J1
Kinyanjui, MW1
Villeneuve, A1
Michael, H1
Fixman, ED1
Smit, J1
Lindell, D1
Wang, K1
Wen, FQ1
Feng, YL1
Ou, XM1
Deng, ZP1
Kim, MJ1
Daviskas, E1
Anderson, SD1
Young, IH1
Ohwada, K1
Watanabe, K1
Okuyama, K1
Ohkawara, Y1
Sugaya, T1
Takayanagi, M1
Ohno, I1
Elnekave, E1
Mentink-Kane, MM1
Hodges, MG1
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Ramalingam, TR1
Thompson, RW1
Kamanaka, M1
Flavell, RA1
Keane-Myers, A1
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Ko, HM1
Kang, NI1
Kim, YS1
Lee, YM1
Jin, ZW1
Jung, YJ1
Im, SY1
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Cho, BH1
López-Boado, YS1
Nakao, I1
Kanaji, S1
Matsushita, H1
Arima, K1
Yuyama, N1
Yamaya, M1
Nakayama, K1
Kubo, H1
Watanabe, M1
Sagara, H1
Sugiyama, K1
Tanaka, H2
Hayashi, H1
Shiraki, A1
Inoue, M1
Okinami, S1
Nagai, H2
Hasegawa, M1
Fukuda, T1
Green, ED1
Hauber, HP1
Zabel, P1
Kasaian, MT1
Miller, DK1
Lewis, JF1
Wasserman, SI1
Ramsdell, JW1
Smith, B1
Robertson, RM1
Robertson, D1
Pavia, D6
Lopez-Vidriero, MT3
Sutton, PP2
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Phipps, RJ1
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Bateman, JR3
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Goodman, AH1
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Millman, FM2
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Coles, S1
Jelihovsky, T1
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Imhof-Burgener, M1
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Scherrer, M1
Bhaskar, KR2
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Bookman, R2
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Demissie, K1
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Tada, S2
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Fujimura, M1
Yasui, M1
Niitani, H1
Matsuda, T1
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Murata, Y1
Fujioka, M1
Tanizaki, Y2
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Mitsunobu, F2
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Mizoguchi, A1
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Narumiya, S1
Mitchell, TA1
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Matthay, MA1
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Kraft, M1
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Morishima, Y1
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Kirkham, S1
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Kim, HO1
Moon, SH1
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Ogbu, C1
Jeong, KW1
Kozu, G1
Nakanishi, H1
Tulic, MK1
Tomkiewicz, R1
Tigani, B1
Schaeublin, E1
Sugar, R1
Jackson, AD1
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Beckmann, N1
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Waldrep, C1
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Dickey, B1
Han, X1
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Justice, JP1
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Mossberg, B1
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Garbe, L1
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Kleinsbauer, JP1
Laval, P2
Mélon, J1
Geubelle, F1
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Leclercq-Fourcart, J1
Maréchal, J1
Eggleston, PA1
Hendley, JO1
Gwaltney, JM1
Eggleston, AW1
Leavell, BS1
Powers, RJ1
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Levison, H1
Cooper, DM1
Blair, H1
Viner, AS1
Zarzecki, S2
Hirsch, J2
Epstein, S2
Ivanova, LA1
Ketiladze, ES1
Naumova, VK1
Rodov, MN1
Mue, S1
Ise, T1
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Nyiredy, G1
Ferenczy, S1
Gamble, JE1
Bizal, JA1
Daetwyler, EP1
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Goswami, S1
Kalb, TH1
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Schmidt, J1
Minker, E1
Paegelow, I1
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Sasaki, T2
Ishihara, H1
Satoh, M1
Masuda, T1
Sasaki, H2
Marom, ZM1
Lang, DM1
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Timms, RM1
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Clinical Trials (38)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC[NCT06152653]Phase 420 participants (Anticipated)Interventional2023-11-21Recruiting
A Mechanistic Pilot Open-label Study to Evaluate the Effect of Benralizumab on Airway Function and Inflammation in Patients With Severe, Poorly-controlled Eosinophilic Asthma Using Inhaled Hyperpolarized 129-Xenon MRI[NCT03733535]29 participants (Actual)Interventional2022-03-01Active, not recruiting
The Effect of Immunostimulation With Polyvalent Mechanical Bacterial Lysate on Changes in the Concentration of iNKT Cells in Children With Allergic Rhinitis.[NCT04802616]Phase 380 participants (Actual)Interventional2021-03-22Completed
The Effect Of Polivalent Mechanical Bacterial Lysate On The Clinical Course Of Grass Pollen-Induced Allergic Rhinitis In Children[NCT04270552]Phase 376 participants (Actual)Interventional2018-04-22Completed
The Effect of Polyvalent Mechanical Bacterial Lysate on the Reduction of Nasal Staphylococcus Aureus Carriage in Children With Pollen Allergic Rhinitis[NCT04637425]Phase 370 participants (Actual)Interventional2018-04-22Completed
Severe Asthma Research Program (SARP) - University of Wisconsin[NCT01760915]107 participants (Actual)Observational2012-11-28Completed
Clinical and Molecular Phenotypes of Severe Asthma[NCT01718197]151 participants (Actual)Observational2012-11-30Completed
A Two-arm, Placebo-controlled, Randomized Clinical Trial to Evaluate the Effect of Tezepelumab on Airway Structure and Function in Patients With Uncontrolled Moderate-to-severe Asthma[NCT05280418]Phase 330 participants (Anticipated)Interventional2022-11-08Recruiting
Severe Asthma Research Program[NCT01606826]1,100 participants (Anticipated)Observational2012-10-31Active, not recruiting
Severe Asthma Research Program[NCT01759186]300 participants (Anticipated)Observational2012-12-31Active, not recruiting
Severe Asthma Research Program (SARP)-Washington University[NCT01716494]121 participants (Actual)Observational2012-10-31Active, not recruiting
The Severe Asthma Research Program at Wake Forest University - Longitudinal Phenomics and Genetics of Severe Asthma.[NCT01750411]87 participants (Actual)Observational2012-12-31Completed
ALXR/FPR Mediated Signaling in Severe Asthma (AMSA)-The Severe Asthma Research Program (SARP) III[NCT01761630]126 participants (Actual)Observational2012-12-31Completed
"Validation of a Questionnaire to Assess Bronchial Mucus Hypersecretion in Asthmatic Patients. Questionnaire T-sec (Secretion Test)."[NCT05546645]100 participants (Anticipated)Observational2023-10-01Recruiting
A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754]Phase 20 participants (Actual)Interventional2021-04-01Withdrawn (stopped due to lack of subject enrollment)
A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483]Phase 28 participants (Actual)Interventional2020-11-06Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects)
Late Phase Administration Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation[NCT03513458]Phase 1/Phase 20 participants (Actual)Interventional2020-09-30Withdrawn (stopped due to [The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic.)
Early Phase Administration of Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation[NCT03513471]Phase 1/Phase 20 participants (Actual)Interventional2019-08-09Withdrawn (stopped due to The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic.)
A Randomized, Double-Blind, Parallel Group Study of ADVAIR™ DISKUS™ 100/50 and FLOVENT™DISKUS™ 100, Both Twice Daily, in a Pediatric Population During the Fall Viral Season.[NCT01192178]Phase 4339 participants (Actual)Interventional2010-08-31Completed
Evaluating the Effects of Curcumin in Moderate to Severe Asthmatics[NCT04353310]Phase 20 participants (Actual)Interventional2021-09-30Withdrawn (stopped due to No funding)
Role of Cough Assist Device in Mechanically Ventilated Patients in Respiratory Intensive Care Unit : Assiut University Experience[NCT05480371]200 participants (Anticipated)Interventional2022-08-01Not yet recruiting
Phase Ib/II Clinical Trial of Topical Verapamil Hydrochloride for Chronic Rhinosinusitis With Nasal Polyps[NCT03102190]Phase 16 participants (Actual)Interventional2017-06-05Terminated (stopped due to Phase II funding not available)
Randomized Double Blind Placebo Controlled Trial of Verapamil in Chronic Rhinosinusitis[NCT02454608]29 participants (Actual)Interventional2015-05-31Terminated (stopped due to Evidence that the dose is insufficient.)
Efficacy and Safety of Fluticasone Furoate/Vilanterol vs. Umeclidinium/Vilanterol in Patients With COPD-asthma Phenotype vs. Emphysema Phenotype. A Controled Clinical Trial.[NCT05342558]Phase 4133 participants (Actual)Interventional2017-09-19Completed
Raman Analysis of Saliva From COPD Patients as New Biomarker: AI-based Point-of-care for the Disease Monitoring and Management[NCT04628962]250 participants (Anticipated)Observational2022-02-01Recruiting
Phenotyping Disease Severity in Asthma: Molecular Investigations of Corticosteroid[NCT05078021]60 participants (Anticipated)Observational2022-04-21Recruiting
A 28 Week, Treatment Randomized, Double -Blind, Placebo-controlled Study of the Effects of cKit Inhibition by Imatinib in Patients With Severe Refractory Asthma (KIA)[NCT01097694]Phase 2176 participants (Actual)Interventional2010-11-30Completed
Bronchial Thermoplasty: Mechanism of Action and Defining Asthma Phenotype[NCT02075151]50 participants (Anticipated)Interventional2014-02-28Not yet recruiting
Clinical Trial of NAC in Asthma[NCT02605824]Phase 41 participants (Actual)Interventional2016-03-31Terminated (stopped due to The study was closed after we determined that this albuterol/NAC regimen may be associated with excessive bronchoconstriction.)
The Effect of NAC on Lung Function and CT Mucus Score[NCT03822637]Phase 430 participants (Anticipated)Interventional2019-02-20Recruiting
Inpatient Clinical Trial of NAC[NCT03581084]Phase 41 participants (Actual)Interventional2018-07-06Terminated (stopped due to The study was redesigned to be conducted in an outpatient setting.)
A Phase 2 Study of the Safety and Efficacy of BIO-11006 in the Treatment of Recurrent Osteosarcoma and Ewing's Sarcoma in Patients With Lung Metastases[NCT04183062]Phase 210 participants (Anticipated)Interventional2019-10-04Active, not recruiting
Anti-inflammatory Effects of Tiotropium in Patients With Stable COPD- A Multicenter Randomized Controlled Double-blind Study[NCT04061161]Phase 450 participants (Anticipated)Interventional2019-08-19Recruiting
: A Phase III Multicenter, Randomized, Parallel Group, Controlled, Double Blind Study to Investigate the Safety and Efficacy of Inhaled Mannitol Over 12 Months in the Treatment of Bronchiectasis.[NCT00669331]Phase 3485 participants (Actual)Interventional2009-11-30Completed
Clinical Evaluation of Low Power Radiofrequency Energy Applied to the Posterior Nasal Nerve Area for Symptomatic Relief of Chronic Rhinitis[NCT03727347]50 participants (Actual)Interventional2018-10-16Completed
Effect of Exposure to Allergens and Air Pollution on Lung Function and Immunity[NCT01792232]18 participants (Actual)Interventional2011-10-31Completed
[NCT00005284]0 participants Observational1985-01-31Completed
Assessment of Radio(Chemo)Therapy-related Dysphagia in Head and Neck Cancer Patients Based on Cough-related Acoustic Features[NCT05865756]40 participants (Anticipated)Interventional2021-04-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Mean Duration of Worsening Asthma Symptoms Associated With the Presence of Moderate or Severe URTS or a Confirmed RV Infection

A worsening asthma day is one on which any of the following occurred: rescue albuterol use above baseline, use of oral/parenteral corticosteroids for asthma, use of asthma medication other than study medication, asthma symptom scores >=3, nighttime awakenings, unscheduled health care visits, or missed school due to asthma. The duration of worsening asthma is the number of consecutive worsening asthma days after the date of a URTS score of 2 (moderate) or 3 (severe) or collection of a mucus sample containing RV (whichever occurred first). Each span of consecutive days is a participant interval. (NCT01192178)
Timeframe: Peak Viral Period (from 30 August 2010 through the end of treatment [up to Week 16])

InterventionDays per participant interval (Mean)
FSC DISKUS 100/50 mcg BID4.1
FP DISKUS 100 mcg BID4.0

Mean Percentage of Asthma-control Days

An asthma-control day was defined as a day without any of the following: rescue albuterol use, use of oral/parenteral corticosteroids for asthma, use of asthma medication other than double-blind study treatment, asthma symptom score >0, nighttime awakenings due to asthma, unscheduled health care visits (defined as home visits, office visits, or urgent care visits), ER visits, hospitalizations for asthma, or school absenteeism due to asthma. The percentage of asthma-control days = the number (No.) of asthma-control days divided by the No. of days of treatment exposure, multiplied by 100. (NCT01192178)
Timeframe: Peak Viral Period (from 30 August 2010 through the end of treatment [up to Week 16])

InterventionPercentage of days (Mean)
FSC DISKUS 100/50 mcg BID48.3
FP DISKUS 100 mcg BID49.7

Mean Percentage of Episode-free (EF) Days

An EF day was defined as a day without any of the following: rescue albuterol use, use of oral/parenteral corticosteroids for asthma, use of asthma medication other than study treatment, asthma symptom score >0, nighttime awakenings due to asthma, unscheduled health care visits (defined as home visits, office visits, or urgent care visits), ER visits, hospitalizations for asthma, school absenteeism due to asthma, or morning peak expiratory flow (measure of maximum airflow) <80% of baseline. Percentage of EF days=No. of EF days divided by No. of days of treatment exposure, multiplied by 100. (NCT01192178)
Timeframe: Peak Viral Period (from 30 August 2010 through the end of treatment [up to Week 16])

InterventionPercentage of days (Mean)
FSC DISKUS 100/50 mcg BID42.4
FP DISKUS 100 mcg BID44.5

Mean Percentage of Rescue-free Days

A rescue-free day was defined as a day during the Peak Viral Period on which no puffs of rescue medication were recorded. Percentage of rescue-free days was defined as the number of days during the Peak Viral Period on which no puffs of rescue medication were recorded, divided by the number of days in that same period on which non-missing values were recorded, multiplied by 100. (NCT01192178)
Timeframe: Peak Viral Period (from 30 August 2010 through the end of treatment [up to Week 16])

InterventionPercentage of days (Mean)
FSC DISKUS 100/50 mcg BID92.1
FP DISKUS 100 mcg BID91.7

Mean Percentage of Symptom-free Days

A symptom-free day was defined as a day during the Peak Viral Period on which the asthma symptom score was zero. The daily asthma symptom score (measured during the day and the previous night) was reported on a 6-point scale (ranging from 0=no symptoms to 5=severe symptoms). Percentage of symptom-free days was defined as the number of days during the Peak Viral Period on which the asthma symptom score=0, divided by the number of days in that same period on which non-missing values were recorded, multiplied by 100. (NCT01192178)
Timeframe: Peak Viral Period (from 30 August 2010 through the end of treatment [up to Week 16])

InterventionPercentage of days (Mean)
FSC DISKUS 100/50 mcg BID90.1
FP DISKUS 100 mcg BID91.1

Number of Asthma Exacerbations Associated With the Presence of Moderate or Severe URTS or a Confirmed RV Infection During the Peak Viral Period

Each participant (with assistance from the parent/legal guardian as needed) was instructed to keep an electronic diary (eDiary) with record of daily URTS symptoms that included: runny nose, sneezing, nasal congestion, and sore throat. Based on the best-described aggregate URTS during the previous 24 hours, participants rated symptoms as: 0 = Not present; 1 = Mild, clearly present; 2 = Moderately severe, uncomfortable; and 3 = Severe, interfering with sleep or activity. Mucus samples were collected and analyzed for RVwhen the eDiary alerted for moderate/severe URTS. (NCT01192178)
Timeframe: Peak Viral Period (from 30 August 2010 through the end of treatment [up to Week 16])

InterventionNumber of asthma exacerbations (Number)
FSC DISKUS 100/50 mcg BID5
FP DISKUS 100 mcg BID7

Total Number of Asthma Exacerbations Reported During the Treatment Period

An asthma exacerbation was defined as deterioration of asthma that required the use of outpatient oral/parenteral corticosteroids (tablets, suspensions, or injection) or an urgent care, hospitalization, or emergency room (ER) visit due to asthma that required oral/parenteral corticosteroids. Two exacerbations (out of a total of 51) were excluded: (1) one exacerbation occurred within 7 days of the resolution of an earlier one, and, per protocol, was combined with the previous exacerbation; and (2) one exacerbation occurred post treatment. (NCT01192178)
Timeframe: From Baseline (Week 1) until the end of treatment (up to Week 16)

InterventionNumber of asthma exacerbations (Number)
FSC DISKUS 100/50 mcg BID24
FP DISKUS 100 mcg BID25

Mean Asthma Symptom Scores, as an Indicator of Severity, Associated With the Presence of Moderate or Severe Upper Respiratory Tract Symptoms (URTS) or a Confirmed Rhinovirus (RV) Infection at Baseline and During the Peak Viral Period

Participants recorded their asthma symptom score over the previous 24 hours (during the day and the previous night) using the following 6-point scale: 0=No symptoms; 1=Symptoms for 1 short period; 2=Symptoms for >=2 short periods; 3=Symptoms for most of the day/previous night that did not affect normal daily activities; 4=Symptoms for most of the day/previous night that affected normal daily activities; 5=Symptoms so severe that participant could not perform normal daily activities. The Baseline mean asthma symptom score was calculated as the average score over 7 days prior to Week 1, Visit 2. (NCT01192178)
Timeframe: Baseline (Week 1) and Peak Viral Period ([period during which the greatest number of viral infections is expected] from 30 August 2010 through the end of the treatment period [up to Week 16])

,
InterventionScores on a scale (Mean)
Baseline, n=105, 104Peak Viral Period, n=106, 104
FP DISKUS 100 mcg BID0.20.4
FSC DISKUS 100/50 mcg BID0.20.5

Number of Participants With Dose Limiting Toxicity

Dose Limiting Toxicity will be defined as a development of 2nd or 3rd degree heart block as measured by an EKG. (Phase Ib primary outcome) (NCT03102190)
Timeframe: 1-8 weeks

InterventionParticipants (Count of Participants)
Phase Ib0

Diastolic Blood Pressure

(NCT02454608)
Timeframe: Mean change between baseline and week 8 measurements

InterventionmmHg (Mean)
Treatment-0.6
Control1

Heart Rate

(NCT02454608)
Timeframe: Mean change between baseline and week 8 measurements.

Interventionbeats per minute (Mean)
Treatment-1.4
Control4

Objective Sinonasal Symptoms on Lund-Kennedy Score(LKS)

Minimum Score: 0 Maximum Score: 12 Higher value represents worse outcome. (NCT02454608)
Timeframe: baseline to week 8

Interventionunits on a scale (Least Squares Mean)
Treatment-1.3
Control-0.25

Objective Sinonasal Symptoms on Lund-McKay Score(LMS)

Minimum Score: 0 Maximum Score: 24 Higher value represents worse outcome. (NCT02454608)
Timeframe: Week 8

Interventionunits on a scale (Mean)
Treatment12.5
Control17.7

Subjective Sinonasal Symptoms on 10cm Visual Analogue Scale(VAS)

Minimum Score: 0 Maximum Score: 100 A higher score indicates a worse outcome. (NCT02454608)
Timeframe: baseline to week 8

Interventionunits on a scale (Least Squares Mean)
Treatment-44.03
Control-6.07

Subjective Sinonasal Symptoms on Sinonasal Outcomes Test-22(SNOT-22)

Minimum Score: 0 Maximum Score: 110 A higher score indicates a worse outcome (NCT02454608)
Timeframe: baseline to week 8

Interventionunits on a scale (Least Squares Mean)
Treatment-27.3
Control0.4

Systolic Blood Pressure

(NCT02454608)
Timeframe: Mean change between baseline and week 8 measurements

InterventionmmHg (Mean)
Treatment-4.5
Control-6.6

Subjective Sinonasal Symptoms on 10cm Visual Analogue Scale(VAS)

Minimum Score: 0 Maximum Score: 100 A higher score indicates a worse outcome. (NCT02454608)
Timeframe: baseline to week 56

Interventionunits on a scale (Mean)
Medicine Completers, baselineMedicine Completers, week 56Surgical Completers, baselineSurgical Completers, week 12
Open Label64.335.090.016.7

Subjective Sinonasal Symptoms on Sinonasal Outcomes Test-22(SNOT-22)

Minimum Score: 0 Maximum Score: 110 A higher score indicates a worse outcome (NCT02454608)
Timeframe: baseline to week 56

Interventionunits on a scale (Mean)
Medicine Completers, baselineMedicine Completers, week 56Surgical Completers, baselineSurgical Completers, week 12
Open Label31.824.1472.008.00

Airway Wall Area

Change in airway wall area as assessed by computerized tomography (CT) (NCT01097694)
Timeframe: 6 months after start of treatment

Intervention% of area (Mean)
Imatinib Mesylate0.0002
Placebo0.0002

Airway Wall Thickness

Change in airway wall thickness as assessed by computerized tomography (CT) (NCT01097694)
Timeframe: 6 months after start of treatment

Intervention% of airway (Mean)
Imatinib Mesylate-0.0040
Placebo-0.0027

Asthma Control Questionnaire (ACQ)

Change in patient-reported ACQ score The six-item Asthma Control Questionnaire (ACQ-6) is a scale from 0 to 6 with a lower value denoting an improvement in asthma control. The minimal important difference is 0.5. (NCT01097694)
Timeframe: 6 months after start of treatment

Interventionunits on a scale (Mean)
Imatinib Mesylate-0.62
Placebo-0.49

Asthma Quality of Life Questionnaire (AQLQ)

Change in patient-reported Asthma Quality of Life Questionnaire (AQLQ) score The asthma quality of life questionnaire (AQLQ) is a 32-item scale with a range from 1-7 with a higher value denoting improvement. The minimal important difference is 0.5. (NCT01097694)
Timeframe: 6 months after start of treatment

Interventionunits on a scale (Mean)
Imatinib Mesylate0.55
Placebo0.25

Asthma Symptom Utility Index (ASUI)

Change in patient reported ASUI score The asthma symptom utility index (ASUI) is a 10-item weighted scale with a range from 0.2 to 1 with a higher value indicating improvement. The minimal important difference is 0.09. (NCT01097694)
Timeframe: 6 months after start of treatment

Interventionunits on a scale (Mean)
Imatinib Mesylate0.07
Placebo0.05

BAL Eosinophil %

Change in BAL eosinophil percentage (NCT01097694)
Timeframe: 6 months after start of treatment

Intervention% eosinophils (Mean)
Imatinib Mesylate2.55
Placebo-2.63

BAL Neutrophil %

Change in BAL neutrophil percentage from baseline (NCT01097694)
Timeframe: 6 months after start of treatment

Intervention% neutrophils (Mean)
Imatinib Mesylate-0.8
Placebo-0.4

Blood Eosinophils

Change in blood eosinophil count (NCT01097694)
Timeframe: 6 months after start of treatment

Interventioneosinophils per microliter (Mean)
Imatinib Mesylate-10.2
Placebo-2.6

Bronchoalveolar Lavage (BAL) Fluid Tryptase Level

Change in BAL fluid tryptase levels after 24 weeks of imatinib vs. placebo (NCT01097694)
Timeframe: 6 months after start of treatment

Interventionng/mL (Mean)
Imatinib Mesylate-0.74
Placebo0.43

Bronchoalveolar Lavage (BAL) PGD2

Change in bronchoalveolar lavage (BAL) PGD2 levels from baseline at 6 months (NCT01097694)
Timeframe: 6 months after start of treatment

Interventionpg/mL (Mean)
Imatinib Mesylate12.2
Placebo-4.2

Bronchoalveolar Lavage Cysteinyl Leukotrienes

Change in bronchoalveolar lavage cysteinyl leukotrienes levels from baseline (NCT01097694)
Timeframe: 6 months after start of treatment

Interventionpg/mL (Mean)
Imatinib Mesylate3.0
Placebo6.5

Bronchoalveolar Lavage Histamine

Change in bronchoalveolar lavage histamine levels from baseline (NCT01097694)
Timeframe: 6 months after start of treatment

InterventionnM (Mean)
Imatinib Mesylate2.1
Placebo-1.1

Change in Maximum Post-Bronchodilator (BD) Forced Expiratory Volume in One Second (FEV1) %

(NCT01097694)
Timeframe: 6 months after start of treatment

Intervention% of predicted (Mean)
Imatinib Mesylate0.01
Placebo-0.08

Change in Mean Methacholine Responsiveness as Assessed by the Provocation Concentration Causing a 20% Fall in Forced Expiratory Volume in One Second (FEV1) (PC20) at Month 3 and 6 Versus Baseline

"Our primary outcome was change in airway hyperresponsiveness, as assessed by PC20, from baseline to 3 and/or 6 months of therapy in imatinib treated participants as compared with controls. Change in PC20 was assessed using log2-transformed ratios of PC20 at month 3 and /or month 6 vs PC20 at baseline. Our null hypothesis was that the mean of this ratio will be 0 after log2-transformed. We used a linear mixed-effects model for a repeated-measures analysis to compare the primary outcome between the two groups.~PC20 is determined by the provocation concentration of methacholine causing a 20% fall in forced expiratory volume in one second (FEV1)." (NCT01097694)
Timeframe: Over 6 months from beginning of treatment

InterventionLog2 Ratio (Mean)
Imatinib Mesylate1.73
Placebo1.07

Endobronchial Biopsy Smooth Muscle Tryptase-positive Mast Cells

Change in the biopsy smooth muscle tryptase-positive mast cells from baseline at 6 months (NCT01097694)
Timeframe: 6 months after start of treatment

Interventionmast cells per mm2 (Mean)
Imatinib Mesylate-102.7
Placebo-79.2

Endobronchial Biopsy Total Tryptase-positive Mast Cells

Change in endobronchial biopsy total tryptase-positive mast cells from baseline at 6 months (NCT01097694)
Timeframe: 6 months after start of treatment

Interventionmast cells per mm2 (Mean)
Imatinib Mesylate-54.2
Placebo-32.3

Evening Peak Flow

Change in patient-reported evening peak flow measurement (L/s) (NCT01097694)
Timeframe: 6 months after start of treatment

InterventionL/second (Mean)
Imatinib Mesylate8.3
Placebo-8.2

FEV1 in Liters

Change in FEV1 in treatment group compared to placebo group (NCT01097694)
Timeframe: 6 months after start of treatment

InterventionL (Mean)
Imatinib Mesylate0.046
Placebo0

FEV1%

Change in FEV1% of predicted (NCT01097694)
Timeframe: 6 months after start of treatment

Intervention% of predicted (Mean)
Imatinib Mesylate2.3
Placebo0.78

Fractional Exhaled Nitric Oxide (FeNO)

Change in Fractional Exhaled Nitric Oxide Measurement (ppb) (NCT01097694)
Timeframe: 6 months after start of treatment

Interventionparts per billion (Mean)
Imatinib Mesylate7.89
Placebo-5.92

Morning Peak Flow Measurement

Change in patient-reported morning peak flow measurement (L/s) (NCT01097694)
Timeframe: 6 months after start of treatment

InterventionL/second (Mean)
Imatinib Mesylate7.3
Placebo-6.4

Number of Asthma Exacerbations

Number of asthma exacerbations experienced from randomization to study completion. (NCT01097694)
Timeframe: Up to 24 weeks

Interventionevents (Number)
Imatinib Mesylate16
Placebo20

Serum Total Tryptase

Change in serum total tryptase after 24 weeks of imatinib vs placebo treatment (NCT01097694)
Timeframe: 6 months after start of treatment

Interventionng/ml (Mean)
Imatinib Mesylate-2.02
Placebo-0.56

Urinary Leukotriene E4

Change in urinary leukotriene E4 levels from baseline (NCT01097694)
Timeframe: 6 months after start of treatment

Interventionng/mg Creatinine (Mean)
Imatinib Mesylate0.07
Placebo0.01

Urinary Prostaglandin D2

Change in urinary Prostaglandin D2 levels from baseline (NCT01097694)
Timeframe: 6 months after start of treatment

Interventionng/mg Creatinine (Mean)
Imatinib Mesylate-0.30
Placebo0.39

Forced Expiratory Volume in One Second (FEV1) Measurement

Post-treatment FEV1 is reported. FEV1 is measured via spirometry. (NCT03581084)
Timeframe: end of the one week treatment period

Interventionliters (Number)
N-acetylcysteine0.86

• (Exploratory) Number of Hospitalizations Due to Pulmonary Exacerbations

Mean rate of hospitalisations (number/year) summarised and analysed to take account of differing follow-up times. (NCT00669331)
Timeframe: 52 weeks

Interventionhospitalisations/year (Mean)
Mannitol0.12
Control0.20

Antibiotic Use Prescribed for Treated Pulmonary Exacerbations

Rate of antibiotic treated graded pulmonary exacerbations, using the same definition of a graded pulmonary exacerbation as the primary endpoint. A graded pulmonary exacerbation was considered to be anti-biotic treated if use of oral, IV or inhaled antibiotic use was recorded related to the GPE event. (NCT00669331)
Timeframe: 52 weeks

Interventionevents/year (Number)
Mannitol1.9
Control2.1

Duration of Graded Exacerbations

Duration of graded exacerbations is defined as the number of days with graded PE within one treatment year. Mean days estimated via negative binomial model with treatment, region and baseline pulmonary exacerbation rate as predictors, with log of follow-up time as the offset variable (NCT00669331)
Timeframe: 52 weeks

InterventionDays with GPE (Mean)
Mannitol31.49
Control35.74

Lung Function - Change in FEF25-75 (Forced Expiratory Flow Rate Averaged Over 25th -75th Percentile of FVC)

(NCT00669331)
Timeframe: 52 weeks

InterventionmL/s (Least Squares Mean)
Mannitol-18.21
Control-3.40

Lung Function - Change in FEV1 (Forced Expiratory Volume in One Second)

(NCT00669331)
Timeframe: 52 weeks

InterventionmL (Least Squares Mean)
Mannitol2.36
Control-5.20

Lung Function - Change in FEV1/FVC

FEV1 expressed as a ratio of FVC. Endpoint is expressed as a percentage ie FEV1/FVC*100 (NCT00669331)
Timeframe: 52 weeks

Interventionratio (expressed as a %) (Least Squares Mean)
Mannitol-0.08
Control0.09

Lung Function - Change in FVC (Forced Vital Capacity)

(NCT00669331)
Timeframe: 52 weeks

InterventionmL (Least Squares Mean)
Mannitol0.15
Control-15.70

Safety Profile - Hematology

hematology assessed as clinically significant abnormal FBC (Full Blood count) at any point post baseline. (NCT00669331)
Timeframe: 52 weeks

Interventionparticipants (Number)
Mannitol13
Control5

Safety Profile - Sputum Microbiology

sputum microbiology assessed as the presence of abnormal flora in sputum sample taken at any post baseline visit (NCT00669331)
Timeframe: 52 weeks

Interventionparticipants (Number)
Mannitol81
Control81

Time to First Graded Exacerbation

Time to first graded exacerbation is defined as the duration (in months) from the randomisation date to the start of the first reported graded PE during the on-treatment period. Patients without reported graded PE event will be censored at the last participation. (NCT00669331)
Timeframe: 52 weeks

Interventionmonths (Median)
Mannitol5.4
Control4.1

Daytime Sleepiness Scores

Epworth Sleepiness Scale (ESS) score was calculated as the sum of scores for each of eight individual questions, such that a total score of zero represents no daytime sleepiness, and a total score of 24 represents the maximum degree of daytime sleepiness. Measured at baseline, 6 weeks, 16 weeks, 28 weeks, 40 weeks, 52 weeks (NCT00669331)
Timeframe: 52 weeks

,
Interventionunits on a scale (Mean)
BaselineWeek 6Week 16Week 28Week 40Week 52
Control6.896.876.506.576.336.34
Mannitol7.236.076.216.056.326.09

Quality of Life as Measured by the St. Georges Respiratory Questionnaire (SGRQ) Total Score

The SGRQ was collected at baseline, week 6, week 16, week 28, week 40 and week 52. Change in total score was calculated from baseline. Total scores are a weighted sum across all questions. Scores are expressed as a percentage of overall impairment where 100 represents worst possible health status and 0 indicates best possible health status. Higher scores indicate lower quality of life. Outcome data table gives the raw mean total score at each visit. (NCT00669331)
Timeframe: 52 weeks

,
Interventionunits on a scale (Mean)
BaselineWeek 6Week 16Week 28Week 40Week 52
Control52.2244.5544.2343.4643.5142.25
Mannitol52.9844.0940.6741.4540.3941.43

Rate of Graded Pulmonary Exacerbations

A graded pulmonary exacerbation was defined as a worsening in signs and symptoms requiring a change in treatment (Center for Drug Evaluation and Research (CDER), 2007). Grade I was required 3 main signs and symptoms, Grade II 2 main signs and symptoms and Grade III 1 main and one or more minor signs and symptoms. Main signs and symptoms were increased cough, sputum volume or sputum purulence. Minor were upper respiratory tract infection, fever, increased wheezing, increased dyspnea, increase in respiratory rate, increase in cardiac frequency of >20%, and increased malaise, fatigue or lethargy. Rate is defined as the number of all GPE events observed in one treatment year (NCT00669331)
Timeframe: 52 weeks

,
InterventionGPE events per year (Number)
Raw rateRate from negative binomial model
Control2.101.84
Mannitol1.951.69

Safety Profile - Clinical Chemistry

Clinical chemistry was assessed as clinically significant abnormal liver function test and clinically significant abnormal urea/electrolyte test at any point post baseline. (NCT00669331)
Timeframe: 52 weeks

,
Interventionparticipants (Number)
Subjects with Clin sig liver funtion tests at wk52Subjects with clin sig urea/electrolyte test wk52
Control00
Mannitol23

Sputum Volume

24 hour sputum weight, measured at baseline, week 6, week 16, week 28, week 40, week 52 (NCT00669331)
Timeframe: 52 weeks

,
Interventiong (Mean)
BaselineWeek 6Week 16Week 28Week 40Week 52
Control28.9622.8220.2518.8818.1718.33
Mannitol28.8824.9723.6922.9221.5620.54

Change in Reflective Total Nasal Symptom Score (rTNSS)

"Mean change in Reflective Total Nasal Symptoms Score (rTNSS) from baseline to 12 weeks post-study procedure. Improvement (12 week score - baseline score) is signified by a negative value.~The Reflective Total Nasal Symptom Score (rTNSS) is a patient self reported questionnaire of four nasal symptoms: rhinitis, nasal congestion, nasal itching and sneezing. Patients will report their symptoms reflected or felt over the last 12 hours. Total scores can range from 0 to 12. A higher score indicates increased symptom severity. This study will measure the mean change in the rTNSS total score from Baseline to 12 week follow up visit" (NCT03727347)
Timeframe: Comparison of scores at Baseline and 12 weeks post procedure

Interventionunits on a scale (Mean)
InSeca Stylus Treatment Group-5.1

Change in rTNSS Over Time

"Reflective Total Nasal Symptom Score (rTNSS) is a patient self reported questionnaire of four nasal symptoms: rhinitis, nasal congestion, nasal itching and sneezing. Patients report their symptoms reflected or felt over the last 12 hours. Total scores range from 0 to 12. A higher score indicates increased symptom severity.~The mean change in the rTNSS total score from Baseline to each follow up visit: 2 weeks, 4 weeks, 12 weeks, 26 weeks and 52 weeks post procedure will be recorded." (NCT03727347)
Timeframe: Baseline to each Follow Up Visit at 2 weeks, 4 weeks, 12 weeks, 26 weeks and 52 weeks post procedure.

Interventionscore on a scale (Mean)
Treatment Group - Baseline8.5
Treatment Group - 2 Week Data4.8
Treatment Group - 4 Week Data3.6
Treatment Group - 12 Week Data3.4
Treatment Group - 26 Week Data3.3
Treatment Group - 52 Week Data3.6

Percentage of Participants With Treatment Related Adverse Events (Safety)

"Characterization of the type and frequency of treatment-related adverse events reported during or following the study procedure. Subjects were asked about possible side effects or adverse experiences related to the study procedure at each follow up visit. Each event was documented and identified as to its relationship and level of relatedness to the study device and/or study procedure.~This measure includes any subject who experienced at least one event considered definitely, probably, or possibly related to the device or procedure." (NCT03727347)
Timeframe: At or following the study procedure, and up to the final study visit at 1 year.

InterventionParticipants (Count of Participants)
InSeca Stylus Treatment Group8

rTNSS Responder Rate

"The Reflective Total Nasal Symptom Score (rTNSS) is a patient self reported questionnaire of four nasal symptoms: rhinitis, nasal congestion, nasal itching and sneezing. Patients report their symptoms reflected or felt over the last 12 hours. Total scores can range from 0 to 12. A higher score indicates increased symptom severity.~Subjects who showed at least a 1 point improvement (decrease) in the reflective Total Nasal Symptom Score (rTNSS) were categorized as responders. An overall responder rate of at least 55% was expected." (NCT03727347)
Timeframe: Comparison of scores at Baseline and 12 weeks post procedure

InterventionParticipants (Count of Participants)
InSeca Stylus Treatment Group46

Change in rTNSS Individual Nasal Symptom Component Scores Over Time

"Reflective Total Nasal Symptom Score (rTNSS) is a patient self reported questionnaire of four nasal symptoms: rhinitis, nasal congestion, nasal itching and sneezing. Patients will report their symptoms reflected or felt over the last 12 hours. Total scores can range from 0 to 12. A higher score indicates increased symptom severity.~Scores from each of the four components of the questionnaire (rhinorrhea, nasal congestion, nasal itching, and sneezing) will be evaluated at each follow up visit at 2 weeks, 4 weeks, 12 weeks, 26 weeks and 52 weeks post procedure. Individual component scores can range from 0 to 3, with a higher score indicating increased symptom severity." (NCT03727347)
Timeframe: Baseline to each Follow Up visit at 2 weeks, 4 weeks, 12 weeks, 26 weeks and 52 weeks post procedure

,,,,,
Interventionscore on a scale (Mean)
RhinorrheaNasal CongestionNasal ItchingSneezing
Treatment Group - 12 Week Data1.01.10.50.9
Treatment Group - 2 Week Data1.61.50.71.0
Treatment Group - 26 Week Data0.91.10.50.8
Treatment Group - 4 Week Data1.21.10.40.8
Treatment Group - 52 Week Data1.11.20.50.8
Treatment Group - Baseline2.52.51.71.9

Response on Aerin Quality-of-Life (QOL) Assessment Items

"This Quality-of-Life (QOL) instrument is a 9-item patient self-reported questionnaire developed by Aerin Medical to gain understanding of the impact of chronic rhinitis on daily activities, feelings, symptoms and medication use. Each item had 5 possible answers to convey the following responses: very positive, positive, neutral, negative and very negative.~Section 1 asks Please indicate how often you experience the following for 6 items. For items 1, 3, 4 and 5, those who answered never/rarely were considered to have a positive (favorable) response. For questions 2 and 6, those who answered frequently/very frequently were considered to have a positive (favorable) response. Section 2 requests Please indicate how often you use each of the following products to help you with your chronic rhinitis. For 3 items in this section, those who answered never/rarely were considered to have a positive (favorable) response." (NCT03727347)
Timeframe: The QOL was to be completed by the subject at baseline prior to the treatment procedure, and at the 12 week, 26 week and 52 week visits post procedure.

InterventionParticipants (Count of Participants)
Section 1, Item 1: Difficulty falling asleep72500892Section 1, Item 1: Difficulty falling asleep72500885Section 1, Item 1: Difficulty falling asleep72500891Section 1, Item 1: Difficulty falling asleep72500893Section 1, Item 2: Good sleep throughout the night72500885Section 1, Item 2: Good sleep throughout the night72500891Section 1, Item 2: Good sleep throughout the night72500892Section 1, Item 2: Good sleep throughout the night72500893Section 1, Item 3: Feeling fatigued during the day72500885Section 1, Item 3: Feeling fatigued during the day72500891Section 1, Item 3: Feeling fatigued during the day72500892Section 1, Item 3: Feeling fatigued during the day72500893Section 1, Item 4: Feelings of frustration/restlessness/irritability72500885Section 1, Item 4: Feelings of frustration/restlessness/irritability72500891Section 1, Item 4: Feelings of frustration/restlessness/irritability72500892Section 1, Item 4: Feelings of frustration/restlessness/irritability72500893Section 1, Item 5: Feelings of embarrassment or self-consciousness72500885Section 1, Item 5: Feelings of embarrassment or self-consciousness72500891Section 1, Item 5: Feelings of embarrassment or self-consciousness72500892Section 1, Item 5: Feelings of embarrassment or self-consciousness72500893Section 1, Item 6: Having a good sense of overall well-being72500885Section 1, Item 6: Having a good sense of overall well-being72500891Section 1, Item 6: Having a good sense of overall well-being72500892Section 1, Item 6: Having a good sense of overall well-being72500893Section 2, Item 1: Oral medications72500885Section 2, Item 1: Oral medications72500891Section 2, Item 1: Oral medications72500892Section 2, Item 1: Oral medications72500893Section 2, Item 2: Nasal sprays72500885Section 2, Item 2: Nasal sprays72500891Section 2, Item 2: Nasal sprays72500892Section 2, Item 2: Nasal sprays72500893Section 2, Item 3: Nasal breathing strips72500885Section 2, Item 3: Nasal breathing strips72500891Section 2, Item 3: Nasal breathing strips72500892Section 2, Item 3: Nasal breathing strips72500893
Positive (favorable) responseNeutral or Negative response
Treatment Group - 12 Week Data23
Treatment Group - 26 Week Data26
Treatment Group - 12 Week Data25
Treatment Group - Baseline11
Treatment Group - 26 Week Data28
Treatment Group - 52 Week Data22
Treatment Group - Baseline35
Treatment Group - 26 Week Data20
Treatment Group - 52 Week Data25
Treatment Group - Baseline3
Treatment Group - 12 Week Data17
Treatment Group - 26 Week Data14
Treatment Group - Baseline43
Treatment Group - 12 Week Data31
Treatment Group - 26 Week Data34
Treatment Group - Baseline7
Treatment Group - 12 Week Data30
Treatment Group - 52 Week Data29
Treatment Group - Baseline39
Treatment Group - 12 Week Data18
Treatment Group - 52 Week Data18
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Treatment Group - 26 Week Data38
Treatment Group - 52 Week Data40
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Treatment Group - 52 Week Data7
Treatment Group - Baseline10
Treatment Group - 12 Week Data20
Treatment Group - 26 Week Data17
Treatment Group - 52 Week Data19
Treatment Group - Baseline36
Treatment Group - 12 Week Data28
Treatment Group - 26 Week Data31
Treatment Group - 52 Week Data28
Treatment Group - Baseline9
Treatment Group - 52 Week Data20
Treatment Group - Baseline37
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Treatment Group - 26 Week Data46
Treatment Group - 52 Week Data45
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Treatment Group - 12 Week Data3
Treatment Group - 26 Week Data2
Treatment Group - 52 Week Data2

Reviews

125 reviews available for guaifenesin and Asthma

ArticleYear
Role of mucolytics in wet cough.
    The Journal of the Association of Physicians of India, 2013, Volume: 61, Issue:5 Suppl

    Topics: Ambroxol; Asthma; Bronchodilator Agents; Cholinergic Antagonists; Cough; Cystic Fibrosis; Expectoran

2013
"Combination" anti-asthmatic therapy: recent developments.
    Current therapeutic research, clinical and experimental, 1974, Volume: 16, Issue:3

    Topics: Aminophylline; Asthma; Barbiturates; Ephedrine; Expectorants; Guaifenesin; Humans; Hydroxyzine; Hypn

1974
Drug treatment in bronchial asthma.
    Seminars in drug treatment, 1973,Spring, Volume: 2, Issue:4

    Topics: Acetylcysteine; Anti-Bacterial Agents; Asthma; Bronchodilator Agents; Caffeine; Drug Combinations; E

1973
Nanoparticles for local delivery of siRNA in lung therapy.
    Advanced drug delivery reviews, 2021, Volume: 179

    Topics: Administration, Inhalation; Asthma; Drug Carriers; Humans; Lung; Lung Neoplasms; Macrophages, Alveol

2021
Nanocarrier-based approaches to combat chronic obstructive pulmonary disease.
    Nanomedicine (London, England), 2022, Volume: 17, Issue:24

    Topics: Asthma; Chronic Disease; Humans; Mucus; Pulmonary Disease, Chronic Obstructive

2022
The Pathology of Asthma: What Is Obstructing Our View?
    Annual review of pathology, 2023, 01-24, Volume: 18

    Topics: Asthma; Humans; Inflammation; Mucus; Sputum

2023
Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers.
    International journal of pharmaceutics, 2023, Mar-05, Volume: 634

    Topics: Asthma; Cystic Fibrosis; Humans; Lung; Mucus; Pulmonary Disease, Chronic Obstructive

2023
More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Airway Remodeling; Animals; Asthma; Chemokines; Epithelial Cells; Epithelium; Humans; Immunoglobulin

2020
Epigenetics of Mucus Hypersecretion in Chronic Respiratory Diseases.
    American journal of respiratory cell and molecular biology, 2018, Volume: 58, Issue:3

    Topics: Asthma; Cystic Fibrosis; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Histone C

2018
Management of airway mucus hypersecretion in chronic airway inflammatory disease: Chinese expert consensus (English edition).
    International journal of chronic obstructive pulmonary disease, 2018, Volume: 13

    Topics: Animals; Asthma; Bronchiectasis; China; Consensus; Cystic Fibrosis; Drainage; Expectorants; Humans;

2018
Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis.
    Respiratory research, 2018, 08-06, Volume: 19, Issue:1

    Topics: Animals; Asthma; Cystic Fibrosis; Humans; Mucus; Neuropeptides; Pulmonary Disease, Chronic Obstructi

2018
Role of microRNAs and exosomes in asthma.
    Current opinion in pulmonary medicine, 2019, Volume: 25, Issue:1

    Topics: Asthma; Exosomes; Gene Expression Profiling; Genome-Wide Association Study; Humans; MicroRNAs; Mucus

2019
Autopsy and Imaging Studies of Mucus in Asthma. Lessons Learned about Disease Mechanisms and the Role of Mucus in Airflow Obstruction.
    Annals of the American Thoracic Society, 2018, Volume: 15, Issue:Suppl 3

    Topics: Airway Obstruction; Asthma; Autopsy; Cytokines; Eosinophils; Humans; Mucus; Multidetector Computed T

2018
Adverse immunological imprinting by cytomegalovirus sensitizing for allergic airway disease.
    Medical microbiology and immunology, 2019, Volume: 208, Issue:3-4

    Topics: Animals; Asthma; Cell Differentiation; Cytokines; Cytomegalovirus Infections; Dendritic Cells; Disea

2019
The role of macrolides in asthma: current evidence and future directions.
    The Lancet. Respiratory medicine, 2014, Volume: 2, Issue:8

    Topics: Anti-Infective Agents; Asthma; Disease Progression; Humans; Immunomodulation; Macrolides; Mucus; Phe

2014
Secretory hyperresponsiveness and pulmonary mucus hypersecretion.
    Chest, 2014, Volume: 146, Issue:2

    Topics: Animals; Asthma; Autonomic Nervous System; Bronchi; Bronchoconstriction; Humans; Mucus

2014
CLCA1 and TMEM16A: the link towards a potential cure for airway diseases.
    Expert review of respiratory medicine, 2015, Volume: 9, Issue:5

    Topics: Anoctamin-1; Asthma; Cell Transdifferentiation; Chloride Channels; Epithelial Cells; Humans; Mucus;

2015
Novel Therapies to Inhibit Mucus Synthesis and Secretion in Airway Hypersecretory Diseases.
    Pharmacology, 2016, Volume: 97, Issue:1-2

    Topics: Airway Remodeling; Asthma; Chloride Channels; Ellagic Acid; ErbB Receptors; GABA Antagonists; Ginkgo

2016
Structural aspects of airway remodeling in asthma.
    Current allergy and asthma reports, 2008, Volume: 8, Issue:6

    Topics: Animals; Asthma; Cell Proliferation; Cytokines; Epithelial Cells; Extracellular Matrix Proteins; Fib

2008
Novel approaches for inhibition of mucus hypersecretion in asthma.
    Recent patents on inflammation & allergy drug discovery, 2007, Volume: 1, Issue:3

    Topics: Airway Obstruction; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Elasticity; Ex

2007
Mucus hypersecretion in asthma: causes and effects.
    Current opinion in pulmonary medicine, 2009, Volume: 15, Issue:1

    Topics: Airway Obstruction; Asthma; Humans; Lung; Mucin 5AC; Mucin-5B; Mucus

2009
Mucins, mucus, and sputum.
    Chest, 2009, Volume: 135, Issue:2

    Topics: Asthma; Bronchitis, Chronic; Cystic Fibrosis; Female; Humans; Male; Mucins; Mucociliary Clearance; M

2009
Gamma-aminobutyric acid nurtures allergic asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2009, Volume: 39, Issue:7

    Topics: Animals; Asthma; Bronchi; Epithelial Cells; gamma-Aminobutyric Acid; Humans; Models, Immunological;

2009
The mechanism of mucus production in bronchial asthma.
    Current medicinal chemistry, 2009, Volume: 16, Issue:22

    Topics: Animals; Asthma; Chloride Channels; Gene Expression; Goblet Cells; Humans; Interleukin-13; Mucin 5AC

2009
Mucus hypersecretion in asthma: intracellular signalling pathways as targets for pharmacotherapy.
    Current opinion in allergy and clinical immunology, 2010, Volume: 10, Issue:1

    Topics: Animals; Asthma; Drug Delivery Systems; Drug Therapy; ErbB Receptors; Goblet Cells; Humans; Hyperpla

2010
Interrupting the cough reflex in asthma.
    Current opinion in allergy and clinical immunology, 2010, Volume: 10, Issue:1

    Topics: Adrenal Cortex Hormones; Asthma; Cough; Expectorants; Humans; Mucus; Reflex

2010
The future in paediatric respirology.
    Respirology (Carlton, Vic.), 2010, Volume: 15, Issue:5

    Topics: Adult; Asthma; Bronchopulmonary Dysplasia; Child; Chronic Disease; Cystic Fibrosis; Humans; Infant,

2010
Role of transforming growth factor-β in airway remodeling in asthma.
    American journal of respiratory cell and molecular biology, 2011, Volume: 44, Issue:2

    Topics: Airway Remodeling; Animals; Asthma; Eosinophils; Goblet Cells; Humans; Inflammation Mediators; Lung;

2011
New pharmacotherapy for airway mucus hypersecretion in asthma and COPD: targeting intracellular signaling pathways.
    Journal of aerosol medicine and pulmonary drug delivery, 2010, Volume: 23, Issue:4

    Topics: Animals; Asthma; Cyclooxygenase 2; Cytokines; Drug Delivery Systems; Goblet Cells; Humans; Hyperplas

2010
[Voice disorders in asthma].
    Laryngo- rhino- otologie, 2010, Volume: 89, Issue:8

    Topics: Administration, Inhalation; Adrenal Cortex Hormones; Asthma; Dysphonia; Humans; Laryngopharyngeal Re

2010
Airway mucus function and dysfunction.
    The New England journal of medicine, 2010, Dec-02, Volume: 363, Issue:23

    Topics: Asthma; Cystic Fibrosis; Humans; Lung Diseases; Mucociliary Clearance; Mucus; Pulmonary Disease, Chr

2010
Airway mucus function and dysfunction.
    The New England journal of medicine, 2010, Dec-02, Volume: 363, Issue:23

    Topics: Asthma; Cystic Fibrosis; Humans; Lung Diseases; Mucociliary Clearance; Mucus; Pulmonary Disease, Chr

2010
Airway mucus function and dysfunction.
    The New England journal of medicine, 2010, Dec-02, Volume: 363, Issue:23

    Topics: Asthma; Cystic Fibrosis; Humans; Lung Diseases; Mucociliary Clearance; Mucus; Pulmonary Disease, Chr

2010
Airway mucus function and dysfunction.
    The New England journal of medicine, 2010, Dec-02, Volume: 363, Issue:23

    Topics: Asthma; Cystic Fibrosis; Humans; Lung Diseases; Mucociliary Clearance; Mucus; Pulmonary Disease, Chr

2010
[Mechanotransduction and the bronchoalveolar epithelium].
    Revue des maladies respiratoires, 2010, Volume: 27, Issue:10

    Topics: Apoptosis; Asthma; Bronchi; Cilia; Collagen; Cytokines; Epithelial Cells; Epithelium; ErbB Receptors

2010
The sentinel role of the airway epithelium in asthma pathogenesis.
    Immunological reviews, 2011, Volume: 242, Issue:1

    Topics: Adaptive Immunity; Adult; Airway Remodeling; Allergens; Animals; Anti-Inflammatory Agents; Asthma; C

2011
Clinical phenotypes of COPD: identification, definition and implications for guidelines.
    Archivos de bronconeumologia, 2012, Volume: 48, Issue:3

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Asthma; Bronchiectasis; Bronchitis; Bronchodilato

2012
Clinical phenotypes of COPD: identification, definition and implications for guidelines.
    Archivos de bronconeumologia, 2012, Volume: 48, Issue:3

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Asthma; Bronchiectasis; Bronchitis; Bronchodilato

2012
Clinical phenotypes of COPD: identification, definition and implications for guidelines.
    Archivos de bronconeumologia, 2012, Volume: 48, Issue:3

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Asthma; Bronchiectasis; Bronchitis; Bronchodilato

2012
Clinical phenotypes of COPD: identification, definition and implications for guidelines.
    Archivos de bronconeumologia, 2012, Volume: 48, Issue:3

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Asthma; Bronchiectasis; Bronchitis; Bronchodilato

2012
The airway epithelium in asthma.
    Nature medicine, 2012, May-04, Volume: 18, Issue:5

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Basement Membrane; Cell Communication; Cytokines; Den

2012
Airway goblet cell hyperplasia in asthma: hypersecretory and anti-inflammatory?
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2002, Volume: 32, Issue:8

    Topics: Animals; Asthma; Goblet Cells; Guinea Pigs; Humans; Hyperplasia; Interleukins; Mice; Models, Animal;

2002
Regulation of the depth and composition of airway surface liquid.
    Journal of anatomy, 2002, Volume: 201, Issue:4

    Topics: Animals; Asthma; Body Water; Bronchitis; Cystic Fibrosis; Ion Channels; Mucus; Respiratory Mucosa; R

2002
Post-secretory fate of host defence components in mucus.
    Novartis Foundation symposium, 2002, Volume: 248

    Topics: Animals; Asthma; Cattle; Cilia; Humans; Hyaluronic Acid; Kallikreins; Lactoperoxidase; Mucins; Mucus

2002
Current and future therapies for airway mucus hypersecretion.
    Novartis Foundation symposium, 2002, Volume: 248

    Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Chloride Channels; Cystic Fibrosis; Drug De

2002
Airway hypersecretion in allergic rhinitis and asthma: new pharmacotherapy.
    Current allergy and asthma reports, 2003, Volume: 3, Issue:3

    Topics: Asthma; Capillary Permeability; Chloride Channels; Glucocorticoids; Histamine Antagonists; Humans; M

2003
Pulmonary mucus: Pediatric perspective.
    Pediatric pulmonology, 2003, Volume: 36, Issue:3

    Topics: Adult; Age Factors; Antioxidants; Asthma; Bronchitis; Child; Cholinergic Antagonists; Cytokines; Enz

2003
[Mechanisms and control of airway remodeling].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2003, Volume: 41, Issue:9

    Topics: Airway Obstruction; Asthma; Basement Membrane; Bronchi; Bronchial Hyperreactivity; Constriction, Pat

2003
Interleukin-13 in asthma pathogenesis.
    Current allergy and asthma reports, 2004, Volume: 4, Issue:2

    Topics: Asthma; Eosinophilia; Epithelial Cells; Humans; Interleukin-13; Interleukin-13 Receptor alpha1 Subun

2004
Airway mucus hypersecretion in asthma: an undervalued pathology?
    Current opinion in pharmacology, 2004, Volume: 4, Issue:3

    Topics: Airway Obstruction; Asthma; Cytokines; Humans; Mucus; Phenotype; Pulmonary Disease, Chronic Obstruct

2004
Post-nasal drip syndrome--a symptom to be sniffed at?
    Pulmonary pharmacology & therapeutics, 2004, Volume: 17, Issue:6

    Topics: Asthma; Cough; Diagnosis, Differential; Gastroesophageal Reflux; Humans; Mucus; Nasal Cavity; Rhinit

2004
Immunomodulatory effects of antimicrobials in the therapy of respiratory tract infections.
    Current opinion in infectious diseases, 2005, Volume: 18, Issue:2

    Topics: Anti-Bacterial Agents; Asthma; Bronchiolitis; Cystic Fibrosis; Cytokines; Gene Expression; Humans; I

2005
Structural changes in the airways in asthma: observations and consequences.
    Clinical science (London, England : 1979), 2005, Volume: 108, Issue:6

    Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Child; Humans; Lung; Mucus; Muscle, S

2005
The aetiology of chronic cough: a review of current theories for the otorhinolaryngologist.
    The Journal of laryngology and otology, 2005, Volume: 119, Issue:7

    Topics: Angiotensin-Converting Enzyme Inhibitors; Asthma; Bronchitis, Chronic; Chronic Disease; Cough; Eosin

2005
Mucus and MUC in asthma.
    Current opinion in pulmonary medicine, 2006, Volume: 12, Issue:1

    Topics: Asthma; Chronic Disease; Humans; Mucins; Mucus; Phenotype; Respiratory Mucosa

2006
Milk consumption does not lead to mucus production or occurrence of asthma.
    Journal of the American College of Nutrition, 2005, Volume: 24, Issue:6 Suppl

    Topics: Animals; Asthma; Evidence-Based Medicine; Humans; Milk; Mucus; Nasal Mucosa; Perception

2005
Regulation of mucin genes in chronic inflammatory airway diseases.
    American journal of respiratory cell and molecular biology, 2006, Volume: 34, Issue:6

    Topics: Animals; Asthma; Cystic Fibrosis; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hum

2006
Novel concepts of neuropeptide-based drug therapy: vasoactive intestinal polypeptide and its receptors.
    European journal of pharmacology, 2006, Mar-08, Volume: 533, Issue:1-3

    Topics: Animals; Asthma; Bronchodilator Agents; Humans; Lung; Mucus; Neuropeptides; Pituitary Adenylate Cycl

2006
Treatment of airway mucus hypersecretion.
    Annals of medicine, 2006, Volume: 38, Issue:2

    Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchitis, Chronic; Drug Design; Goblet Ce

2006
Is the neutrophil a worthy target in severe asthma and chronic obstructive pulmonary disease?
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2006, Volume: 36, Issue:5

    Topics: Asthma; Humans; Interleukin-5; Lung; Mucus; Neutrophils; Pulmonary Disease, Chronic Obstructive; Tre

2006
Muscarinic receptor signaling in the pathophysiology of asthma and COPD.
    Respiratory research, 2006, May-09, Volume: 7

    Topics: Acetylcholine; Animals; Asthma; Bronchodilator Agents; Cell Differentiation; Cell Proliferation; Fib

2006
Asthma exacerbations . 3: Pathogenesis.
    Thorax, 2006, Volume: 61, Issue:10

    Topics: Acute Disease; Allergens; Asthma; Bronchiolitis; Disease Susceptibility; Environmental Pollutants; H

2006
Novel medications for asthma: a look at the future.
    Expert opinion on investigational drugs, 2007, Volume: 16, Issue:6

    Topics: Airway Obstruction; Animals; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Drug Delivery

2007
Respiratory syncytial virus-induced pulmonary disease and exacerbation of allergic asthma.
    Contributions to microbiology, 2007, Volume: 14

    Topics: Animals; Asthma; Chemokines; Dendritic Cells; Disease Models, Animal; Humans; Immunity, Innate; Mice

2007
Physiology of airway mucus secretion and pathophysiology of hypersecretion.
    Respiratory care, 2007, Volume: 52, Issue:9

    Topics: Anti-Inflammatory Agents; Asthma; Bronchi; Cystic Fibrosis; Humans; Inhalation Exposure; Intracellul

2007
Role of airway epithelial cells in development of asthma and allergic rhinitis.
    Respiratory medicine, 2008, Volume: 102, Issue:7

    Topics: Asthma; Bronchi; Cytokines; Epithelial Cells; Humans; Inflammation Mediators; Mucus; Rhinitis; Th2 C

2008
Macrolides as immunomodulatory medications for the therapy of chronic lung diseases.
    Current opinion in pharmacology, 2008, Volume: 8, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Asthma; Chronic Disease; Cystic Fibrosis; Defensins; Epithelial Cell

2008
Emerging mucus regulating drugs in inflammatory and allergic lung disease.
    Inflammation & allergy drug targets, 2008, Volume: 7, Issue:1

    Topics: Asthma; Cystic Fibrosis; Humans; Lung Diseases, Obstructive; Mucins; Mucus; Respiratory System Agent

2008
IL-13 as a therapeutic target for respiratory disease.
    Biochemical pharmacology, 2008, Jul-15, Volume: 76, Issue:2

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Fibrosis; Humans; Inflammation; Interleukin-13; Interleu

2008
Acute bronchial asthma.
    Emergency medicine clinics of North America, 1983, Volume: 1, Issue:2

    Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Aero

1983
The airway mucociliary system.
    International review of physiology, 1981, Volume: 23

    Topics: Animals; Asthma; Autonomic Nervous System; Biological Transport; Bronchi; Bronchitis; Calcium; Cats;

1981
The pathology of asthma.
    Clinics in chest medicine, 1984, Volume: 5, Issue:4

    Topics: Asthma; Bronchi; Bronchial Spasm; Edema; Humans; Mucous Membrane; Mucus; Muscle, Smooth

1984
Experimental models of asthma.
    Lung, 1982, Volume: 160, Issue:5

    Topics: Airway Resistance; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Cilia; Disease Models, Ani

1982
Management of asthma in the child aged under 6 years.
    British medical journal (Clinical research ed.), 1981, Jun-13, Volume: 282, Issue:6280

    Topics: Allergens; Asthma; Attitude to Health; Bronchodilator Agents; Child; Child, Preschool; Cromolyn Sodi

1981
Cellular mechanisms in the pathogenesis and pathophysiology of asthma.
    The Medical clinics of North America, 1981, Volume: 65, Issue:5

    Topics: Aged; Airway Obstruction; Asthma; Atropine; Bronchial Spasm; Calcium; Eosinophils; Humans; Immunity,

1981
Chronic cough and expectoration in patients with asthma and in patients with alpha1-antitrypsin deficiency.
    European journal of respiratory diseases. Supplement, 1982, Volume: 118

    Topics: alpha 1-Antitrypsin Deficiency; Asthma; Bronchitis; Chronic Disease; Cough; Female; Humans; Male; Mu

1982
[Dysphonia produced by corticoid inhalation: truth or myth?].
    Archivos de bronconeumologia, 1995, Volume: 31, Issue:8

    Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Child; Female; Glottis; Humans;

1995
[Mechanisms of bronchial hyperreactivity. Role of the epithelium].
    Revue des maladies respiratoires, 1994, Volume: 11, Issue:2

    Topics: Animals; Antigens, CD; Asthma; Biopsy; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capi

1994
Airway goblet cells: responsive and adaptable front-line defenders.
    The European respiratory journal, 1994, Volume: 7, Issue:9

    Topics: Animals; Asthma; Bronchitis; Cystic Fibrosis; Exocrine Glands; Humans; Hyperplasia; Mucins; Mucus; P

1994
[Bronchial asthma with hypersecretion].
    Ryoikibetsu shokogun shirizu, 1994, Issue:3

    Topics: Asthma; Humans; Mucus

1994
[Bronchial hyperreactivity: neurogenic factors].
    Revue des maladies respiratoires, 1994, Volume: 11, Issue:2

    Topics: Adrenergic Fibers; Afferent Pathways; Asthma; Autonomic Nervous System; Bronchial Hyperreactivity; C

1994
Late-phase reaction in asthma: basic mechanisms.
    International archives of allergy and immunology, 1993, Volume: 101, Issue:3

    Topics: Asthma; Basophils; Bronchoconstriction; Cell Degranulation; Eosinophils; Forced Expiratory Volume; H

1993
Smooth muscle as a direct or indirect target accounting for bronchopulmonary hyperresponsiveness.
    Research in immunology, 1997, Volume: 148, Issue:1

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Humans; Inflammation; Inflammation

1997
[Airway hypersecretion and mucociliary dysfunction in asthma].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 111, Issue:4

    Topics: Animals; Asthma; Bronchi; Humans; Mucociliary Clearance; Mucus

1998
Plasma-derived proteins in airway defence, disease and repair of epithelial injury.
    The European respiratory journal, 1998, Volume: 11, Issue:4

    Topics: Animals; Asthma; Blood Proteins; Epithelium; Exudates and Transudates; Humans; Mucous Membrane; Mucu

1998
Allergic bronchopulmonary aspergillosis.
    Annual review of medicine, 1999, Volume: 50

    Topics: Administration, Oral; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Asthma; Bronc

1999
Therapeutic aerosols and airway secretions.
    Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine, 1996,Spring, Volume: 9, Issue:1

    Topics: Aerosols; Animals; Anti-Asthmatic Agents; Asthma; Cystic Fibrosis; Drug Combinations; Fatty Alcohols

1996
Therapeutic advances: leukotriene antagonists for the treatment of asthma.
    Journal of clinical pharmacy and therapeutics, 1999, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Anti-Asthmatic Agents; Asthma; Bronchoconstriction; Capillary Permeability; Child

1999
Airway inflammation and remodeling in asthma.
    Current opinion in pulmonary medicine, 2000, Volume: 6, Issue:1

    Topics: Airway Obstruction; Asthma; Basement Membrane; Bronchi; Bronchial Hyperreactivity; Bronchitis; Const

2000
Exogenous surfactant therapy and mucus rheology in chronic obstructive airway diseases.
    Journal of biomaterials applications, 2000, Volume: 14, Issue:3

    Topics: Animals; Asthma; Bronchitis; Cystic Fibrosis; Humans; Mucociliary Clearance; Mucus; Pulmonary Surfac

2000
Inflammatory and structural changes in the airways of patients with asthma.
    Respiratory medicine, 2000, Volume: 94 Suppl D

    Topics: Asthma; Bronchi; Circadian Rhythm; Epithelium; Humans; Mucus; Respiratory System

2000
The effect of inflammation on mucociliary clearance in asthma: an overview.
    Chest, 2000, Volume: 118, Issue:4

    Topics: Animals; Asthma; Biomarkers; Bronchitis; Chronic Disease; Histamine; Humans; Leukotrienes; Mucocilia

2000
Mucus pathophysiology in COPD: differences to asthma, and pharmacotherapy.
    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 2000, Volume: 55, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Enzyme Inhibitors; Expectorants; Humans; Lung Disea

2000
Biopsy markers of airway inflammation and remodelling.
    Respiratory medicine, 2000, Volume: 94 Suppl F

    Topics: Asthma; Biomarkers; Biopsy; Bronchitis; Chronic Disease; Growth Substances; Humans; Mucus; Muscle, S

2000
Leukotrienes as mediators of asthma.
    Pulmonary pharmacology & therapeutics, 2001, Volume: 14, Issue:1

    Topics: Animals; Asthma; Cell Division; Humans; Inflammation; Leukotriene Antagonists; Leukotrienes; Mucus;

2001
Role of epidermal growth factor receptor activation in regulating mucin synthesis.
    Respiratory research, 2001, Volume: 2, Issue:2

    Topics: Animals; Asthma; Cell Differentiation; Cell Division; Epithelial Cells; ErbB Receptors; Goblet Cells

2001
Remodeling of the airway epithelium in asthma.
    American journal of respiratory and critical care medicine, 2001, Nov-15, Volume: 164, Issue:10 Pt 2

    Topics: Animals; Asthma; Biopsy; Bronchi; Bronchoconstriction; Capillary Permeability; Cell Degranulation; C

2001
Mucoactive drugs for asthma and COPD: any place in therapy?
    Expert opinion on investigational drugs, 2002, Volume: 11, Issue:1

    Topics: Asthma; Clinical Trials as Topic; Deoxyribonuclease I; Expectorants; Humans; Iodides; Mucins; Mucus;

2002
Effects of drugs on mucus glycoproteins and water in bronchial secretion.
    The Journal of international medical research, 1979, Volume: 7, Issue:5

    Topics: Adrenergic beta-Agonists; Animals; Asthma; Bronchi; Bronchodilator Agents; Carbocysteine; Cyclic AMP

1979
Clinical aspects of mucociliary transport.
    The American review of respiratory disease, 1977, Volume: 116, Issue:1

    Topics: Air Pollutants; Anesthetics; Animals; Asthma; Bronchitis; Chronic Disease; Cilia; Cystic Fibrosis; H

1977
The role of mucociliary dysfunction in bronchial asthma.
    The American journal of medicine, 1979, Volume: 67, Issue:3

    Topics: Animals; Antigens; Ascaris; Asthma; Bronchi; Bronchial Spasm; Cilia; Dogs; Humans; Hypersensitivity,

1979
Asthma: the important questions. Part 2.
    The American review of respiratory disease, 1992, Volume: 146, Issue:5 Pt 1

    Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Body Temperature Regulation; Chronic Dise

1992
Azelastine: a multifaceted drug for asthma therapy.
    Agents and actions. Supplements, 1991, Volume: 34

    Topics: Animals; Asthma; Free Radicals; Histamine H1 Antagonists; Humans; Interleukin-1; Mucociliary Clearan

1991
The role of mast cells in bronchial asthma: mechanisms and possible therapeutic implications.
    The Mount Sinai journal of medicine, New York, 1991, Volume: 58, Issue:6

    Topics: Animals; Asthma; Bronchial Spasm; Humans; Mast Cells; Mucous Membrane; Mucus

1991
The lung mucosa: a critical environmental battleground.
    The American journal of medicine, 1991, Oct-21, Volume: 91, Issue:4A

    Topics: Adult; Air Pollutants; Asthma; Child; Humans; Lung; Lung Diseases, Obstructive; Mucociliary Clearanc

1991
Permeability of the airway mucosa in asthma.
    The European respiratory journal. Supplement, 1991, Volume: 13

    Topics: Animals; Asthma; Extracellular Space; Humans; Mucous Membrane; Mucus; Permeability; Respiratory Syst

1991
The potential roles of leukotrienes in bronchial asthma.
    The American review of respiratory disease, 1991, Volume: 143, Issue:5 Pt 2

    Topics: Airway Obstruction; Asthma; Edema; Humans; Hypersensitivity, Immediate; Leukotriene Antagonists; Leu

1991
Morphology of the airway wall in asthma and in chronic obstructive pulmonary disease.
    The American review of respiratory disease, 1991, Volume: 143, Issue:5 Pt 1

    Topics: Asthma; Bronchi; Humans; Lung; Lung Diseases, Obstructive; Microscopy, Electron; Microscopy, Electro

1991
Mechanisms by which glucocorticosteroids inhibit secretion of mucus in asthmatic airways.
    The American review of respiratory disease, 1990, Volume: 141, Issue:2 Pt 2

    Topics: Animals; Asthma; Eicosanoids; Glucocorticoids; Humans; Models, Biological; Mucus; Respiratory System

1990
Mechanisms of glucocorticosteroid action in bronchial asthma.
    The Journal of allergy and clinical immunology, 1985, Volume: 76, Issue:2 Pt 2

    Topics: Adenylyl Cyclases; Arachidonic Acid; Arachidonic Acids; Asthma; Basophils; Bronchial Spasm; Capillar

1985
Mode of action of corticosteroids in asthma and rhinitis.
    Clinical allergy, 1986, Volume: 16, Issue:4

    Topics: Adrenal Cortex Hormones; Asthma; Basophils; Bronchi; Eosinophils; Histamine Release; Humans; Immunog

1986
Role of airway epithelial cells in the defense of airways.
    Progress in clinical and biological research, 1988, Volume: 263

    Topics: Asthma; Bronchi; Epithelial Cells; Humans; Ion Channels; Mucus; Muscle, Smooth; Trachea

1988
Anticholinergic drugs in the treatment of airways disease.
    British journal of diseases of the chest, 1985, Volume: 79, Issue:3

    Topics: Adrenergic beta-Agonists; Asthma; Atropine; Atropine Derivatives; Bronchi; Bronchial Provocation Tes

1985
Calcium, calcium channel blockade and airways function.
    Acta pharmacologica et toxicologica, 1986, Volume: 58 Suppl 2

    Topics: Adrenergic beta-Agonists; Allergens; Angina Pectoris; Animals; Asthma; Bronchi; Calcium; Calcium Cha

1986
Airway mucus membrane: effects of beta-adrenergic and anticholinergic stimulation.
    The American journal of medicine, 1986, Nov-14, Volume: 81, Issue:5A

    Topics: Adrenergic beta-Agonists; Aerosols; Asthma; Biological Transport; Bronchodilator Agents; Epithelium;

1986
Mast cell mediators and asthma.
    Chest, 1987, Volume: 91, Issue:6 Suppl

    Topics: Animals; Asthma; Autacoids; Bronchial Spasm; Cytoplasmic Granules; Edema; Humans; Immunoglobulin E;

1987
[Bronchial asthma and prostaglandin related substances].
    Nihon rinsho. Japanese journal of clinical medicine, 1985, Volume: 43, Issue:3

    Topics: Animals; Arachidonic Acids; Asthma; Bronchi; Capillary Permeability; Guinea Pigs; Humans; In Vitro T

1985
The role of eicosanoids in respiratory mucus hypersecretion.
    Annals of allergy, 1985, Volume: 55, Issue:1

    Topics: Animals; Arachidonic Acids; Aspirin; Asthma; Bronchial Diseases; Cells, Cultured; Fatty Acids, Unsat

1985
The role of leukotrienes in asthma.
    Annals of the Academy of Medicine, Singapore, 1985, Volume: 14, Issue:3

    Topics: Airway Resistance; Animals; Asthma; Bronchi; Chemical Phenomena; Chemistry; Hemodynamics; Humans; In

1985
Lipid-derived and other chemical mediators of inflammation in the lung.
    The Journal of allergy and clinical immunology, 1987, Volume: 79, Issue:4

    Topics: Anaphylatoxins; Arachidonic Acid; Arachidonic Acids; Asthma; Eicosanoic Acids; Fatty Acids; Humans;

1987
Prostaglandins and the lung.
    Lung, 1986, Volume: 164, Issue:2

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Asthma; Bronchi; Heart Defects, Congenital; Humans; In

1986
Theophylline and mucociliary clearance.
    Chest, 1987, Volume: 92, Issue:1 Suppl

    Topics: Aminophylline; Animals; Asthma; Bronchitis; Cilia; Clinical Trials as Topic; Dogs; Humans; Lung Dise

1987
Epidemiology of bronchial hypersecretion: recent studies.
    European journal of respiratory diseases. Supplement, 1987, Volume: 153

    Topics: Airway Obstruction; Anti-Bacterial Agents; Asthma; Bronchial Diseases; Bronchitis; Epidemiologic Met

1987
The pathology of obstructive and inflammatory airway diseases.
    European journal of respiratory diseases. Supplement, 1986, Volume: 147

    Topics: Animals; Asthma; Bronchi; Bronchiectasis; Bronchiolitis, Viral; Bronchitis; Child; Dogs; Humans; Lun

1986
Continuing medical education. Asthma in infants and children: Part 1.
    The Journal of allergy and clinical immunology, 1985, Volume: 76, Issue:1

    Topics: Airway Resistance; Allergens; Aspirin; Asthma; Asthma, Exercise-Induced; Bronchi; Child; Child, Pres

1985
Effects of inhaled acids on respiratory tract defense mechanisms.
    Environmental health perspectives, 1985, Volume: 63

    Topics: Acids; Aerosols; Air Pollutants; Animals; Asthma; Bronchi; Dose-Response Relationship, Drug; Epithel

1985
Clinical aspects of mucus and mucous plugging in asthma.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 1985, Volume: 22, Issue:6

    Topics: Acetylcysteine; Asthma; Biological Transport; Bronchi; Cilia; Expectorants; Humans; Mucus; Pulmonary

1985
Immunoglobulin E and immediate hypersensitivity.
    Vox sanguinis, 1970, Volume: 19, Issue:1

    Topics: Adolescent; Antibodies; Antibodies, Anti-Idiotypic; Antibody Formation; Ascariasis; Asthma; Binding

1970
Tracheobronchial secretions.
    The American journal of medicine, 1971, Volume: 50, Issue:4

    Topics: Adenocarcinoma, Bronchiolo-Alveolar; Antibody Formation; Asthma; Atropine; Bronchi; Bronchitis; Carb

1971
[Normal and pathological bronchial secretion].
    Studii si cercetari de medicina interna, 1973, Volume: 14, Issue:4

    Topics: Asthma; Bronchi; Bronchial Diseases; Bronchitis; Chromatography; Cystic Fibrosis; Elasticity; Humans

1973
The clinical significance of IgE.
    Progress in clinical immunology, 1972, Volume: 1

    Topics: Absorption; Antibodies, Heterophile; Antibody Specificity; Asthma; Binding, Competitive; Colostrum;

1972

Trials

26 trials available for guaifenesin and Asthma

ArticleYear
Controlled assessment of oral bronchodilators for asthmatic children.
    The Journal of international medical research, 1978, Volume: 6, Issue:4

    Topics: Administration, Oral; Adolescent; Asthma; Barbiturates; Bronchodilator Agents; Child; Clinical Trial

1978
Effect of bromhexine and guaiphenesine on clinical state, ventilatory capacity and sputum viscosity in chronic asthma.
    Scandinavian journal of respiratory diseases, 1976, Volume: 57, Issue:2

    Topics: Airway Resistance; Asthma; Bromhexine; Chronic Disease; Clinical Trials as Topic; Female; Guaifenesi

1976
Clinical evaluation of terbutaline and glyceryl guaiacolate in chronic obstructive lung disease.
    Current therapeutic research, clinical and experimental, 1976, Volume: 19, Issue:3

    Topics: Adult; Aged; Asthma; Bronchitis; Chronic Disease; Clinical Trials as Topic; Female; Guaifenesin; Hum

1976
The use of Duopect as expectorant--antitussive agent.
    Archivum immunologiae et therapiae experimentalis, 1975, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Aged; Asthma; Bronchiectasis; Bronchitis; Chronic Disease; Clinical Trials as Top

1975
Guaiphenesin and iodide.
    Drug and therapeutics bulletin, 1985, Aug-12, Volume: 23, Issue:16

    Topics: Asthma; Clinical Trials as Topic; Double-Blind Method; Guaifenesin; Humans; Iodides; Lung Diseases;

1985
Clinical trial with terbutaline and guajacol.
    Scandinavian journal of respiratory diseases, 1973, Volume: 54, Issue:2

    Topics: Adult; Aged; Asthma; Bronchodilator Agents; Butylamines; Clinical Trials as Topic; Cough; Drug Combi

1973
Changes in the fibre system and viscosity of the sputum of bronchitis during treatment with bromhexine and guaiphenesin (guaiacol glyceryl ether).
    Scandinavian journal of respiratory diseases. Supplementum, 1974, Volume: 90

    Topics: Adult; Aged; Asthma; Bromhexine; Bronchitis; Clinical Trials as Topic; Depression, Chemical; DNA; Fe

1974
Double-blind evaluation of an anti-asthmatic agent.
    Annals of allergy, 1967, Volume: 25, Issue:10

    Topics: Adolescent; Adult; Asthma; Bronchodilator Agents; Child; Clinical Trials as Topic; Female; Guaifenes

1967
A controlled evaluation of oral theophylline in asthmatic children.
    Annals of allergy, 1968, Volume: 26, Issue:10

    Topics: Asthma; Capsules; Child; Clinical Trials as Topic; Drug Synergism; Epinephrine; Female; Guaifenesin;

1968
Asthma Control, Airway Mucus, and
    Chest, 2022, Volume: 162, Issue:3

    Topics: Airway Management; Airway Obstruction; Anti-Asthmatic Agents; Antibodies, Monoclonal, Humanized; Ast

2022
Effects of Dupilumab on Mucus Plugging and Ventilation Defects in Patients with Moderate-to-Severe Asthma: A Randomized, Double-Blind, Placebo-Controlled Trial.
    American journal of respiratory and critical care medicine, 2023, 11-01, Volume: 208, Issue:9

    Topics: Antibodies, Monoclonal, Humanized; Asthma; Double-Blind Method; Humans; Injections, Subcutaneous; Mu

2023
Randomised study of the immunomodulatory effects of azithromycin in severely asthmatic horses.
    The Veterinary record, 2019, 08-03, Volume: 185, Issue:5

    Topics: Airway Remodeling; Animals; Asthma; Azithromycin; Cross-Over Studies; Female; Horse Diseases; Horses

2019
The assessment and management of chronic cough in children according to the British Thoracic Society guidelines: descriptive, prospective, clinical trial.
    The clinical respiratory journal, 2014, Volume: 8, Issue:3

    Topics: Adolescent; Asthma; Bronchitis; Child; Child, Preschool; Chronic Disease; Cough; Female; Gastroesoph

2014
The association between seasonal asthma exacerbations and viral respiratory infections in a pediatric population receiving inhaled corticosteroid therapy with or without long-acting beta-adrenoceptor agonist: a randomized study.
    Respiratory medicine, 2015, Volume: 109, Issue:10

    Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Bronchodilato

2015
Bronchoalveolar lavage in asthma: the effect of disodium cromoglycate (cromolyn) on leukocyte counts, immunoglobulins, and complement.
    The Journal of allergy and clinical immunology, 1984, Volume: 74, Issue:1

    Topics: Adolescent; Adult; Asthma; Clinical Trials as Topic; Complement System Proteins; Cromolyn Sodium; Fe

1984
Cough and expectoration: general discussion.
    European journal of respiratory diseases. Supplement, 1980, Volume: 110

    Topics: Acute Disease; Asthma; Biological Transport; Bronchitis; Chronic Disease; Cilia; Clinical Trials as

1980
Abnormal mucociliary transport in allergic patients with antigen-induced bronchospasm: role of slow reacting substance of anaphylaxis.
    The American review of respiratory disease, 1981, Volume: 124, Issue:2

    Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Chromone

1981
The effects of a community-based pulmonary rehabilitation programme on exercise tolerance and quality of life: a randomized controlled trial.
    The European respiratory journal, 1997, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Aged; Asthma; Breathing Exercises; Combined Modality Therapy; Community Health Se

1997
Substance P and its receptor neurokinin 1 expression in asthmatic airways.
    The Journal of allergy and clinical immunology, 2000, Volume: 106, Issue:4

    Topics: Adult; Anti-Bacterial Agents; Asthma; Biopsy; Bronchi; Epithelium; Female; Forced Expiratory Volume;

2000
The protective effect of ketotifen in bronchial asthma.
    The Journal of international medical research, 1978, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Dyspnea;

1978
A double blind trial of a 2% solution of sodium cromoglycate in perennial rhinitis.
    Clinical allergy, 1975, Volume: 5, Issue:2

    Topics: Adolescent; Adult; Allergens; Asthma; Child; Clinical Trials as Topic; Cromolyn Sodium; Desensitizat

1975
The effect of unproductive coughing/FET on regional mucus movement in the human lungs.
    Respiratory medicine, 1991, Volume: 85 Suppl A

    Topics: Aerosols; Aged; Asthma; Bronchitis; Cough; Female; Humans; Lung; Male; Middle Aged; Mucociliary Clea

1991
Theophylline and mucociliary clearance.
    Chest, 1987, Volume: 92, Issue:1 Suppl

    Topics: Aminophylline; Animals; Asthma; Bronchitis; Cilia; Clinical Trials as Topic; Dogs; Humans; Lung Dise

1987
Effect of bromhexine on ventilatory capacity in patients with a variety of chest diseases.
    Lancet (London, England), 1969, Nov-22, Volume: 2, Issue:7630

    Topics: Adult; Airway Resistance; Aniline Compounds; Asthma; Chronic Disease; Clinical Trials as Topic; Fema

1969
A new mucolytic, bromhexine ("bisolvon"). A double-blind study.
    The Medical journal of Australia, 1971, May-01, Volume: 1, Issue:18

    Topics: Aniline Compounds; Asthma; Bronchiectasis; Bronchitis; Clinical Trials as Topic; Expectorants; Femal

1971
The acute action of urea on ventilatory function in patients with asthma.
    The Medical journal of Australia, 1967, Jul-08, Volume: 2, Issue:2

    Topics: Adult; Aerosols; Aged; Asthma; Clinical Trials as Topic; Female; Humans; Isoproterenol; Male; Middle

1967

Other Studies

555 other studies available for guaifenesin and Asthma

ArticleYear
High throughput virtual screening strategy to develop a potential treatment for bronchial asthma by targeting interleukin 13 cytokine signaling.
    Allergologia et immunopathologia, 2022, Volume: 50, Issue:6

    Topics: Animals; Asthma; Child; Cytokines; Disease Models, Animal; Epinephrine; Guaifenesin; Humans; Hyperse

2022
Theophylline glyceryl guaiacolate (Quibron) in bronchial asthma.
    Diseases of the chest, 1962, Volume: 42

    Topics: Asthma; Guaifenesin; Theophylline

1962
ADDITION OF GLYCERYL GUAIACOLATE TO OXTRIPHYLLINE IN CHRONIC ASTHMA: A DOUBLE BLIND STUDY.
    Annals of allergy, 1963, Volume: 21

    Topics: Asthma; Choline; Double-Blind Method; Guaifenesin; Humans; Theophylline

1963
A DOUBLE BLIND CLINICAL EVALUATION OF GLYCERYL GUAIACOLATE.
    Annals of allergy, 1963, Volume: 21

    Topics: Asthma; Bronchiectasis; Bronchitis; Choline; Cough; Double-Blind Method; Guaifenesin; Pulmonary Emph

1963
THEOPHYLLINE-GLYCERYL GUAIACOLATE CAPSULES (QUIBRON). CLINICAL RESULTS IN BRONCHIAL ASTHMA.
    Journal - Michigan State Medical Society, 1963, Volume: 62

    Topics: Asthma; Capsules; Guaiacol; Guaifenesin; Humans; Theophylline; Toxicology

1963
CLINICAL EVALUATION OF A BRONCHODILATOR DRUG COMBINATION IN CHILDREN WITH CHRONIC BRONCHIAL ASTHMA.
    Annals of allergy, 1964, Volume: 22

    Topics: Adolescent; Aerosols; Anti-Allergic Agents; Asthma; Bronchodilator Agents; Child; Drug Combinations;

1964
TREATMENT OF BRONCHIAL AND PULMONARY PARENCHYMAL DISORDERS.
    The Journal of the Medical Society of New Jersey, 1964, Volume: 61

    Topics: Asthma; Bronchitis; Geriatrics; Guaifenesin; Humans; Lung Diseases; Pulmonary Emphysema; Pulmonary F

1964
OXTRIPHYLLINE-GLYCERYL GUAIACOLATE ELIXIR AS EFFECTIVE THERAPY FOR CHRONIC BRONCHITIS AND ASTHMA.
    Journal of the American Geriatrics Society, 1964, Volume: 12

    Topics: Adolescent; Asthma; Bronchitis; Bronchitis, Chronic; Child; Choline; Geriatrics; Guaifenesin; Humans

1964
GUAIACOL GLYCERYL ETHER THEOPHYLLINATE. ITS VALUE FOR RELIEF OF BRONCHIAL ASTHMA AND RELATED BRONCHOSPASTIC CONDITIONS.
    Industrial medicine & surgery, 1964, Volume: 33

    Topics: Aminophylline; Asthma; Blood; Bronchial Spasm; Drug Therapy; Guaifenesin; Humans; Theophylline

1964
OXTRIPHYLLINE GLYCERYL GUAIACOLATE ELIXIR IN PEDIATRIC ASTHMA: WITH A THEOPHYLLINE REVIEW.
    Annals of allergy, 1965, Volume: 23

    Topics: Adolescent; Asthma; Biomedical Research; Child; Choline; Drug Therapy; Expectorants; Glycerol; Guaia

1965
Theophylline-glyceryl guaiacolate elixir (Quibron) clinical and blood level studies in bronchial asthma in children.
    Annals of allergy, 1962, Volume: 20

    Topics: Asthma; Cardiovascular Agents; Guaifenesin; Muscle Relaxants, Central; Research; Theophylline

1962
Spontaneous dissolution of a guaifenesin stone.
    The Canadian journal of urology, 2005, Volume: 12, Issue:4

    Topics: Adult; Asthma; Expectorants; Guaifenesin; Humans; Male; Remission, Spontaneous; Urinary Calculi

2005
Effect of an anti-asthmatic compound on blood pressure of hypertensive asthmatic patients.
    Annals of allergy, 1967, Volume: 25, Issue:5

    Topics: Adult; Aged; Asthma; Blood Pressure; Female; Guaifenesin; Humans; Hypertension; Male; Middle Aged; P

1967
Drugs used in the treatment of asthma.
    Comprehensive therapy, 1977, Volume: 3, Issue:1

    Topics: Acetylcysteine; Adrenal Cortex Hormones; Aerosols; Asthma; Cromolyn Sodium; Dexamethasone; Drug Comb

1977
Nasal congestion as a side effect of cromolyn sodium.
    The Journal of allergy and clinical immunology, 1974, Volume: 53, Issue:4

    Topics: Asthma; Cromolyn Sodium; Guaifenesin; Humans; Male; Nasal Mucosa; Prednisone; Skin Tests; Theophylli

1974
Clinical evaluation of an antiasthmatic compound. Correlation of absorption with blood levels of theophylline.
    The Nebraska state medical journal, 1966, Volume: 51, Issue:8

    Topics: Adult; Aged; Asthma; Guaifenesin; Humans; Male; Middle Aged; Phenylpropanolamine; Sympathomimetics;

1966
[Therapy of bronchial asthma].
    Deutsche medizinische Wochenschrift (1946), 1974, Oct-25, Volume: 99, Issue:43

    Topics: Adrenal Cortex Hormones; Aminophylline; Asthma; Breathing Exercises; Bromhexine; Cromolyn Sodium; Cy

1974
The effect of the combination of phenobarbitone, ephedrine, aminophylline and glyceryl guaiacolate on asthma and chronic bronchitis.
    The Indian journal of chest diseases, 1973, Volume: 15, Issue:4

    Topics: Adult; Aminophylline; Asthma; Bronchitis; Drug Combinations; Ephedrine; Female; Guaifenesin; Humans;

1973
False-positive tests for urinary 5-hydroxyindoleacetic acid. Error in laboratory determinations caused by glyceryl guaiacolate.
    JAMA, 1970, Feb-16, Volume: 211, Issue:7

    Topics: Asthma; Carcinoid Tumor; False Positive Reactions; Guaifenesin; Humans; Hydroxyindoleacetic Acid

1970
Gekko gecko extract attenuates airway inflammation and mucus hypersecretion in a murine model of ovalbumin-induced asthma.
    Journal of ethnopharmacology, 2022, Jan-10, Volume: 282

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; COVID-19; Cytokines; Female; F

2022
Titanium Dioxide Nanoparticles Exacerbate Allergic Airway Inflammation via TXNIP Upregulation in a Mouse Model of Asthma.
    International journal of molecular sciences, 2021, Sep-14, Volume: 22, Issue:18

    Topics: Animals; Apoptosis; Asthma; bcl-2-Associated X Protein; Bronchoalveolar Lavage Fluid; Carrier Protei

2021
Mucus targeting as a plausible approach to improve lung function in COVID-19 patients.
    Medical hypotheses, 2021, Volume: 156

    Topics: Asthma; COVID-19; Humans; Lung; Mucus; SARS-CoV-2

2021
Ding Chuan Tang Attenuates Airway Inflammation and Eosinophil Infiltration in Ovalbumin-Sensitized Asthmatic Mice.
    BioMed research international, 2021, Volume: 2021

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Down-Regulation; Eosinophi

2021
Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma.
    Allergology international : official journal of the Japanese Society of Allergology, 2022, Volume: 71, Issue:2

    Topics: Asthma; Case-Control Studies; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Humans; Mu

2022
Mucus Plugs in Asthma at CT Associated with Regional Ventilation Defects at
    Radiology, 2022, Volume: 303, Issue:1

    Topics: Asthma; Female; Helium; Humans; Lung; Magnetic Resonance Imaging; Male; Mucus; Respiration Disorders

2022
The prevalence of mucus plugging in severe eosinophilic asthma and its relationship to clinical efficacy of anti-IL-5R treatment.
    The journal of allergy and clinical immunology. In practice, 2022, Volume: 10, Issue:4

    Topics: Asthma; Eosinophils; Humans; Mucus; Prevalence; Pulmonary Eosinophilia; Treatment Outcome

2022
Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma.
    Science translational medicine, 2022, 01-12, Volume: 14, Issue:627

    Topics: Animals; Asthma; Humans; Lung; Macrophages; Mice; Mucus; Oncostatin M

2022
CTNNAL1 participates in the regulation of mucus overproduction in HDM-induced asthma mouse model through the YAP-ROCK2 pathway.
    Journal of cellular and molecular medicine, 2022, Volume: 26, Issue:5

    Topics: alpha Catenin; Animals; Asthma; Disease Models, Animal; Humans; Interleukin-13; Interleukin-4; Lung;

2022
Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time.
    American journal of respiratory and critical care medicine, 2022, 05-01, Volume: 205, Issue:9

    Topics: Asthma; Cross-Sectional Studies; Humans; Lung; Mucus; Respiratory Function Tests

2022
Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease.
    International journal of molecular sciences, 2022, Jan-19, Volume: 23, Issue:3

    Topics: Animals; Asthma; Cells, Cultured; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Ca

2022
Persistent Airway Plugs: A Call for Clinical Recognition and Novel Therapies.
    American journal of respiratory and critical care medicine, 2022, 05-01, Volume: 205, Issue:9

    Topics: Asthma; Humans; Lung; Mucus

2022
Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology.
    Nature communications, 2022, 03-28, Volume: 13, Issue:1

    Topics: Asthma; Child; Epithelium; Humans; Metaplasia; Mucin 5AC; Mucus; Transcriptome

2022
Azithromycin inhibits mucin secretion, mucous metaplasia, airway inflammation, and airways hyperresponsiveness in mice exposed to house dust mite extract.
    American journal of physiology. Lung cellular and molecular physiology, 2022, 05-01, Volume: 322, Issue:5

    Topics: Adenosine Triphosphate; Allergens; Animals; Asthma; Azithromycin; Disease Models, Animal; Inflammati

2022
Study Effect of Azithromycin and Doxycycline in Mucus Producing and Inflammatory Signaling Pathways of Allergic Asthma.
    Iranian journal of allergy, asthma, and immunology, 2022, Apr-11, Volume: 21, Issue:2

    Topics: Animals; Asthma; Azithromycin; Cyclooxygenase 2; Doxycycline; Humans; Immunoglobulin E; Inflammation

2022
Processed product (Pinelliae Rhizoma Praeparatum) of Pinellia ternata (Thunb.) Breit. Alleviates the allergic airway inflammation of cold phlegm via regulation of PKC/EGFR/MAPK/PI3K-AKT signaling pathway.
    Journal of ethnopharmacology, 2022, Sep-15, Volume: 295

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; ErbB Receptors; Expectorants; Inflammation

2022
Iristectorigenin A exerts novel protective properties against airway inflammation and mucus hypersecretion in OVA-induced asthmatic mice: Iristectorigenin A ameliorates asthma phenotype.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 104

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Immunoglobulin E; Immunoglobu

2022
Selective Pharmaceutical Inhibition of PARP14 Mitigates Allergen-Induced IgE and Mucus Overproduction in a Mouse Model of Pulmonary Allergic Response.
    ImmunoHorizons, 2022, 07-11, Volume: 6, Issue:7

    Topics: Allergens; Animals; Asthma; Disease Models, Animal; Immunoglobulin E; Mice; Mucus; Pharmaceutical Pr

2022
[Research on function of Feilike Mixture in stopping cough, eliminating phlegm and relieving asthma based on animal experiments and network pharmacology].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:14

    Topics: Animal Experimentation; Animals; Asthma; Cough; Drugs, Chinese Herbal; Guinea Pigs; Mice; Mucus; Net

2022
Oxysophocarpine inhibits airway inflammation and mucus hypersecretion through JNK/AP-1 pathway in vivo and in vitro.
    Fitoterapia, 2022, Volume: 162

    Topics: Alkaloids; Animals; Antioxidants; Asthma; Cytokines; Disease Models, Animal; Eosine Yellowish-(YS);

2022
Intravital imaging of mucus transport in asthmatic mice using microscopic optical coherence tomography.
    American journal of physiology. Lung cellular and molecular physiology, 2022, 10-01, Volume: 323, Issue:4

    Topics: Adenosine Triphosphate; Animals; Asthma; Interleukin-13; Intravital Microscopy; Mice; Mucus; Saline

2022
Autocrine TGF-alpha is associated with Benzo(a)pyrene-induced mucus production and MUC5AC expression during allergic asthma.
    Ecotoxicology and environmental safety, 2022, Volume: 241

    Topics: Animals; Asthma; Benzo(a)pyrene; Cytokines; ErbB Receptors; Humans; Lung; Mice; Mice, Inbred BALB C;

2022
[Artificial intelligence-assisted identification of mucus plugs in asthma].
    Zhonghua yi xue za zhi, 2022, Sep-13, Volume: 102, Issue:34

    Topics: Artificial Intelligence; Asthma; Humans; Mucus; Pulmonary Disease, Chronic Obstructive; Tomography,

2022
Luminal mucus plugs are spatially associated with airway wall thickening in severe COPD and asthma: A single-centered, retrospective, observational study.
    Respiratory medicine, 2022, Volume: 202

    Topics: Aged; Asthma; Female; Humans; Lung; Male; Middle Aged; Mucus; Pulmonary Disease, Chronic Obstructive

2022
Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice.
    Environmental pollution (Barking, Essex : 1987), 2022, Dec-15, Volume: 315

    Topics: Animals; Arsenic; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Drinking

2022
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.
    Allergology international : official journal of the Japanese Society of Allergology, 2023, Volume: 72, Issue:2

    Topics: Asthma; Eosinophils; Humans; Inflammation; Lung; Mucus; Smoking; Sputum

2023
CT Mucus Score and
    Chest, 2023, Volume: 164, Issue:1

    Topics: Airway Obstruction; Anti-Asthmatic Agents; Asthma; Humans; Magnetic Resonance Imaging; Mucus; Nitric

2023
Importance of mucus burden and mucociliary impairment in asthma.
    The Journal of allergy and clinical immunology, 2023, Volume: 151, Issue:5

    Topics: Asthma; Bronchi; Cilia; Humans; Mucociliary Clearance; Mucus

2023
Effects of Shiwei Longdanhua formula on LPS induced airway mucus hypersecretion, cough hypersensitivity, oxidative stress and pulmonary inflammation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 163

    Topics: Animals; Asthma; Chronic Disease; Cough; Hypersensitivity; Inflammation; Lipopolysaccharides; Mice;

2023
Effect of Benralizumab on Mucus Plugs in Severe Eosinophilic Asthma.
    International archives of allergy and immunology, 2023, Volume: 184, Issue:8

    Topics: Anti-Asthmatic Agents; Asthma; Disease Progression; Eosinophils; Humans; Mucus; Pulmonary Eosinophil

2023
Imaging Regional Airway Involvement of Asthma: Heterogeneity in Ventilation, Mucus Plugs and Remodeling.
    Advances in experimental medicine and biology, 2023, Volume: 1426

    Topics: Asthma; Humans; Lung; Mucus; Respiration; Tomography, X-Ray Computed

2023
An asthma phenotype comprising bronchial wall thickening and mucus plugging confers worse clinical outcomes.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2023, Volume: 131, Issue:4

    Topics: Asthma; Bronchi; Humans; Mucus; Phenotype

2023
Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway.
    Immunobiology, 2023, Volume: 228, Issue:5

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Humans; Hypersensitivity; Inf

2023
Qufeng Xuanbi Formula inhibited benzo[a]pyrene-induced aggravated asthma airway mucus secretion by AhR/ROS/ERK pathway.
    Journal of ethnopharmacology, 2024, Jan-30, Volume: 319, Issue:Pt 1

    Topics: Air Pollutants; Animals; Asthma; Benzo(a)pyrene; Disease Models, Animal; Extracellular Signal-Regula

2024
Melia azedarach L. reduces pulmonary inflammation and mucus hypersecretion on a murine model of ovalbumin exposed asthma.
    Journal of ethnopharmacology, 2024, Feb-10, Volume: 320

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Inflammation; Meli

2024
Niclosamide repurposed for the treatment of inflammatory airway disease.
    JCI insight, 2019, 08-08, Volume: 4, Issue:15

    Topics: Animals; Anoctamins; Anti-Inflammatory Agents; Asthma; Bronchi; Cell Line, Tumor; Cystic Fibrosis; D

2019
Piperlongumine reduces ovalbumin‑induced asthma and airway inflammation by regulating nuclear factor‑κB activation.
    International journal of molecular medicine, 2019, Volume: 44, Issue:5

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Dioxolanes; Fibrosis; Humans; I

2019
Butylphthalide ameliorates airway inflammation and mucus hypersecretion via NF-κB in a murine asthma model.
    International immunopharmacology, 2019, Volume: 76

    Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Benzofurans; Bronchoalv

2019
MiR-31-5p: A shared regulator of chronic mucus hypersecretion in asthma and chronic obstructive pulmonary disease.
    Allergy, 2020, Volume: 75, Issue:3

    Topics: Asthma; Humans; MicroRNAs; Mucus; Pulmonary Disease, Chronic Obstructive

2020
CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma.
    Chest, 2019, Volume: 156, Issue:4

    Topics: Asthma; Humans; Magnetic Resonance Imaging; Mucus; Respiratory System; Tomography, X-Ray Computed

2019
Response.
    Chest, 2019, Volume: 156, Issue:4

    Topics: Asthma; Humans; Magnetic Resonance Imaging; Mucus; Respiratory System; Tomography, X-Ray Computed

2019
Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2).
    Scientific reports, 2019, 10-30, Volume: 9, Issue:1

    Topics: Animals; Asthma; Carrier Proteins; Child; Child, Preschool; Disease Models, Animal; Female; Humans;

2019
Baicalein attenuates OVA-induced allergic airway inflammation through the inhibition of the NF-κB signaling pathway.
    Aging, 2019, 11-06, Volume: 11, Issue:21

    Topics: Animals; Antioxidants; Asthma; Cell Line; Collagen; Drug Evaluation, Preclinical; Flavanones; Immuno

2019
4-Hydroxycinnamic acid suppresses airway inflammation and mucus hypersecretion in allergic asthma induced by ovalbumin challenge.
    Phytotherapy research : PTR, 2020, Volume: 34, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Coumaric Acids; Cyclooxygen

2020
Effect of NF-κB signal pathway on mucus secretion induced by atmospheric PM
    Ecotoxicology and environmental safety, 2020, Mar-01, Volume: 190

    Topics: Air Pollutants; Animals; Asthma; Female; Inflammation; Lung; Male; Mucus; NF-kappa B; NF-KappaB Inhi

2020
Tree Nuts Anaphylaxis in Preschool Age Children.
    European annals of allergy and clinical immunology, 2020, 01-08, Volume: 52, Issue:4

    Topics: Allergens; Anacardium; Anaphylaxis; Asthma; Child, Preschool; Cross Reactions; Female; Humans; Immun

2020
Changes in airway diameter and mucus plugs in patients with asthma exacerbation.
    PloS one, 2020, Volume: 15, Issue:2

    Topics: Airway Obstruction; Asthma; Bronchi; Female; Humans; Male; Middle Aged; Mucus; Prognosis; Tomography

2020
Warifteine and methylwarifteine inhibited the type 2 immune response on combined allergic rhinitis and asthma syndrome (CARAS) experimental model through NF-кB pathway.
    International immunopharmacology, 2020, Volume: 85

    Topics: Alkaloids; Animals; Anti-Allergic Agents; Asthma; Behavior, Animal; Bronchoalveolar Lavage Fluid; Ci

2020
Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma.
    Cell reports, 2020, 07-07, Volume: 32, Issue:1

    Topics: Asthma; Biological Transport; Cellular Reprogramming; Child; Cilia; Down-Regulation; Endoplasmic Ret

2020
Panax notoginseng saponin R1 modulates TNF-α/NF-κB signaling and attenuates allergic airway inflammation in asthma.
    International immunopharmacology, 2020, Volume: 88

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Disease Models, Ani

2020
The establishment of humanized IL-4/IL-4RA mouse model by gene editing and efficacy evaluation.
    Immunobiology, 2020, Volume: 225, Issue:5

    Topics: Allergens; Animals; Antibodies, Monoclonal; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; D

2020
Monocyte chemotactic protein-inducing protein 1 negatively regulating asthmatic airway inflammation and mucus hypersecretion involving γ-aminobutyric acid type A receptor signaling pathway in vivo and in vitro.
    Chinese medical journal, 2020, Sep-30, Volume: 134, Issue:1

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; gamma-Aminobutyric Acid; Inflammation; Mice; Mice, In

2020
4-Carvomenthenol ameliorates the murine combined allergic rhinitis and asthma syndrome by inhibiting IL-13 and mucus production via p38MAPK/NF-κB signaling pathway axis.
    International immunopharmacology, 2020, Volume: 88

    Topics: Allergens; Animals; Anti-Allergic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Female; I

2020
Procedures to Evaluate Inflammatory and Pathological Changes During Allergic Airway Inflammation.
    Methods in molecular biology (Clifton, N.J.), 2021, Volume: 2223

    Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Progression; Lung; Mice

2021
TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 134

    Topics: Acupuncture Therapy; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Anima

2021
Disulfide disruption reverses mucus dysfunction in allergic airway disease.
    Nature communications, 2021, 01-11, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Animals; Asthma; Disease Models, Animal; Disulfides; Expectorants; Female; Glycop

2021
Long non-coding RNA TUG1 promotes airway remodeling and mucus production in asthmatic mice through the microRNA-181b/HMGB1 axis.
    International immunopharmacology, 2021, Volume: 94

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Cells, Cultured; Disease Models, Animal; Female; HMGB

2021
Epithelial miR-141 regulates IL-13-induced airway mucus production.
    JCI insight, 2021, 03-08, Volume: 6, Issue:5

    Topics: Airway Remodeling; Animals; Aspergillus; Asthma; Cell Differentiation; Cells, Cultured; Clustered Re

2021
Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma.
    PloS one, 2021, Volume: 16, Issue:3

    Topics: Animals; Asthma; Disease Models, Animal; Mice; Mucus; Polyporaceae; Th2 Cells

2021
Modeling Airway Dysfunction in Asthma Using Synthetic Mucus Biomaterials.
    ACS biomaterials science & engineering, 2021, 06-14, Volume: 7, Issue:6

    Topics: Adult; Asthma; Biocompatible Materials; Child; Humans; Interleukin-13; Mucus; Respiratory Mucosa

2021
Tectochrysin ameliorates murine allergic airway inflammation by suppressing Th2 response and oxidative stress.
    European journal of pharmacology, 2021, Jul-05, Volume: 902

    Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Basophil

2021
Eosinophil Extracellular Traps in the Casts of Plastic Bronchitis Associated With Influenza Virus Infection.
    Chest, 2021, Volume: 160, Issue:3

    Topics: Airway Obstruction; Asthma; Bronchitis; Cell Aggregation; Cell Death; Child; Chromatin; Eosinophils;

2021
sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma.
    Immunological investigations, 2022, Volume: 51, Issue:5

    Topics: Animals; Asthma; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Glyco

2022
Mucociliary Clearance Differs in Mild Asthma by Levels of Type 2 Inflammation.
    Chest, 2021, Volume: 160, Issue:5

    Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoscopy; Cell Adhesion Molecules; Chemokine CCL26;

2021
Interesting case of allergic broncho pulmonary aspergillosis (ABPA) with high-attenuation mucus (HAM).
    BMJ case reports, 2021, May-24, Volume: 14, Issue:5

    Topics: Adult; Aspergillosis, Allergic Bronchopulmonary; Asthma; Bronchiectasis; Humans; Lung; Male; Mucus

2021
Pingchuan formula attenuates airway mucus hypersecretion via regulation of the PNEC-GABA-IL13-Muc5ac axis in asthmatic mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 140

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Proliferation; Cytokines;

2021
CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A.
    International journal of molecular sciences, 2021, May-12, Volume: 22, Issue:10

    Topics: Animals; Anoctamin-1; Asthma; Chloride Channels; Goblet Cells; Metaplasia; Mice; Mucus; Ovalbumin; R

2021
Association of the CFTR gene with asthma and airway mucus hypersecretion.
    PloS one, 2021, Volume: 16, Issue:6

    Topics: Asthma; Cough; Cross-Sectional Studies; Cystic Fibrosis Transmembrane Conductance Regulator; Eosinop

2021
Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Rα in Muco-Secretory Fibrotic Disorders.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Asthma; DNA-Binding Proteins; Female; Fibrosis; Interleukin-13; Interleukin-4 Receptor alph

2021
Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease.
    International journal of molecular sciences, 2021, Jul-22, Volume: 22, Issue:15

    Topics: Animals; Anoctamin-1; Asthma; Constriction, Pathologic; Cystic Fibrosis; HEK293 Cells; Humans; Infla

2021
IRE1β does not affect mucus secretion during allergic asthma development in a house dust mite murine model.
    Allergy, 2021, Volume: 76, Issue:11

    Topics: Allergens; Animals; Asthma; Disease Models, Animal; Humans; Mice; Mucus; Pyroglyphidae

2021
Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus.
    Allergology international : official journal of the Japanese Society of Allergology, 2017, Volume: 66, Issue:4

    Topics: Adult; Aged; Animals; Asthma; Chronic Disease; Disease Models, Animal; Eosinophils; Female; Fibrin;

2017
Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients.
    The Journal of allergy and clinical immunology, 2018, Volume: 141, Issue:1

    Topics: Animals; Asthma; Disease Models, Animal; Epithelial Cells; Humans; Immunity, Innate; Interleukin-13;

2018
Anti‑inflammatory effects of dihydromyricetin in a mouse model of asthma.
    Molecular medicine reports, 2017, Volume: 15, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models,

2017
Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice.
    Scientific reports, 2017, 04-11, Volume: 7

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flu

2017
BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
    Mucosal immunology, 2018, Volume: 11, Issue:1

    Topics: Airway Remodeling; Airway Resistance; Animals; ARNTL Transcription Factors; Asthma; Bronchiolitis, V

2018
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
    Lung, 2017, Volume: 195, Issue:5

    Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid

2017
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
    Lung, 2017, Volume: 195, Issue:5

    Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid

2017
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
    Lung, 2017, Volume: 195, Issue:5

    Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid

2017
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
    Lung, 2017, Volume: 195, Issue:5

    Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid

2017
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
    Lung, 2017, Volume: 195, Issue:5

    Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid

2017
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
    Lung, 2017, Volume: 195, Issue:5

    Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid

2017
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
    Lung, 2017, Volume: 195, Issue:5

    Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid

2017
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
    Lung, 2017, Volume: 195, Issue:5

    Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid

2017
The Immunotherapeutic Role of Bacterial Lysates in a Mouse Model of Asthma.
    Lung, 2017, Volume: 195, Issue:5

    Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid

2017
Isoimperatorin attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma.
    International immunopharmacology, 2017, Volume: 49

    Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Cytokines; Disease Models, Animal; Female; Fur

2017
Roles for Myoepithelial Cells in the Formation and Maintenance of Submucosal Glands.
    American journal of respiratory cell and molecular biology, 2017, Volume: 56, Issue:6

    Topics: Animals; Asthma; Cystic Fibrosis; Epithelial Cells; Exocrine Glands; Humans; Lung; Mucus; Pulmonary

2017
MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma.
    Chest, 2017, Volume: 152, Issue:4

    Topics: Acute Disease; Adolescent; Asthma; Biomarkers; Blotting, Western; Child; Child, Preschool; Female; H

2017
Therapeutic intranasal instillation of allergen-loaded microbubbles suppresses experimental allergic asthma in mice.
    Biomaterials, 2017, Volume: 142

    Topics: Adjuvants, Immunologic; Administration, Intranasal; Allergens; Animals; Antibody Formation; Asthma;

2017
Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma.
    Molecular medicine reports, 2017, Volume: 16, Issue:4

    Topics: Animals; Arginase; Asthma; Bronchoalveolar Lavage Fluid; Cell Differentiation; Disease Models, Anima

2017
Artemisia argyi attenuates airway inflammation in ovalbumin-induced asthmatic animals.
    Journal of ethnopharmacology, 2017, Sep-14, Volume: 209

    Topics: Animals; Artemisia; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Extracellular Signal-Regulated

2017
Leptin positively regulates MUC5AC production and secretion induced by interleukin-13 in human bronchial epithelial cells.
    Biochemical and biophysical research communications, 2017, 11-18, Volume: 493, Issue:2

    Topics: Asthma; Bronchi; Cell Line; Humans; Interleukin-13; Janus Kinase 2; Leptin; Mucin 5AC; Mucus; Respir

2017
Inverted Mucoid Impaction Signal in Allergic Bronchopulmonary Aspergillosis: Are We Calling a Spade a Big Spoon?
    Radiology, 2017, Volume: 285, Issue:2

    Topics: Aspergillosis, Allergic Bronchopulmonary; Asthma; Humans; Mucus

2017
[Receptor for advanced glycation end products upregulates MUC5AC expression and promotes mucus overproduction in mice with toluene diisocyanate-induced asthma].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2017, Oct-20, Volume: 37, Issue:10

    Topics: Animals; Asthma; Benzamides; Butadienes; Extracellular Signal-Regulated MAP Kinases; Mice; Mice, Inb

2017
Activating prostaglandin E2 receptor subtype EP4 increases secreted mucin from airway goblet cells.
    Pulmonary pharmacology & therapeutics, 2018, Volume: 48

    Topics: Asthma; Bronchi; Cells, Cultured; Dinoprostone; Epithelial Cells; Goblet Cells; Humans; Interleukin-

2018
Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9
    The Journal of allergy and clinical immunology, 2018, Volume: 142, Issue:3

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Female; Interleukin-1 Receptor-Like 1 Prot

2018
[Clinical therapeutic effect on bronchial asthma in children of different body constitutions treated with
    Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2017, Apr-12, Volume: 37, Issue:4

    Topics: Acupuncture Points; Asthma; Body Constitution; Child; Humans; Immunoglobulin A; Immunoglobulin G; Im

2017
Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivo.
    The Journal of allergy and clinical immunology, 2018, Volume: 142, Issue:5

    Topics: Allergens; Alternaria; Animals; Asthma; Cytokines; Dermatophagoides pteronyssinus; Eosinophilia; Fem

2018
All plugged up - noninvasive mucus score to assess airway dysfunction in asthma.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Asthma; Eosinophilia; Humans; Lung; Mucus

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
    The Journal of clinical investigation, 2018, 03-01, Volume: 128, Issue:3

    Topics: Adult; Asthma; Case-Control Studies; Cysteine; Elasticity; Eosinophil Peroxidase; Eosinophilia; Fema

2018
Spatiotemporal organization of cilia drives multiscale mucus swirls in model human bronchial epithelium.
    Scientific reports, 2018, 02-05, Volume: 8, Issue:1

    Topics: Asthma; Biomechanical Phenomena; Bronchi; Bronchoscopy; Case-Control Studies; Cilia; Humans; Hydrody

2018
Mucus hypersecretion in asthma is associated with rhinosinusitis, polyps and exacerbations.
    Respiratory medicine, 2018, Volume: 135

    Topics: Adult; Aged; Asthma; Cough; Disease Progression; Female; Humans; Male; Middle Aged; Mucus; Olfaction

2018
Effects of ozone repeated short exposures on the airway/lung inflammation, airway hyperresponsiveness and mucus production in a mouse model of ovalbumin-induced asthma.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 101

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Enzyme-Linked Immunosorbent Assa

2018
Casticin alleviates lipopolysaccharide-induced inflammatory responses and expression of mucus and extracellular matrix in human airway epithelial cells through Nrf2/Keap1 and NF-κB pathways.
    Phytotherapy research : PTR, 2018, Volume: 32, Issue:7

    Topics: Animals; Asthma; Epithelial Cells; Extracellular Matrix; Flavonoids; Humans; Lipopolysaccharides; Mu

2018
LPS Exposure in Early Life Protects Against Mucus Hypersecretion in Ovalbumin-Induced Asthma by Down-Regulation of the IL-13 and JAK-STAT6 Pathways.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 46, Issue:3

    Topics: Administration, Intranasal; Animals; Asthma; Cell Line; Disease Models, Animal; Down-Regulation; Hum

2018
Eicosapentaenoic Acid Enhances the Effects of Mesenchymal Stromal Cell Therapy in Experimental Allergic Asthma.
    Frontiers in immunology, 2018, Volume: 9

    Topics: Animals; Asthma; Biomarkers; Bone Marrow; Bronchoalveolar Lavage Fluid; Cytokines; Eicosapentaenoic

2018
Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: a novel role for CCL20 in chronic mucus hypersecretion.
    The European respiratory journal, 2018, Volume: 52, Issue:2

    Topics: Adolescent; Adult; Aged; Asthma; Case-Control Studies; Cells, Cultured; Chemokine CCL20; Epithelial

2018
Airway smooth muscle may drive mucus hypersecretion in asthma.
    The European respiratory journal, 2018, Volume: 52, Issue:2

    Topics: Asthma; Chemokine CCL20; Humans; Interleukin-1beta; Mucus; Muscle, Smooth; Myocytes, Smooth Muscle

2018
An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
    Science translational medicine, 2018, 08-22, Volume: 10, Issue:455

    Topics: Airway Remodeling; Airway Resistance; Animals; Asthma; Bronchi; Cell Count; Disease Models, Animal;

2018
An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases.
    American journal of respiratory and critical care medicine, 2019, 01-15, Volume: 199, Issue:2

    Topics: Acetylcysteine; Animals; Asthma; Cystic Fibrosis; Disease Models, Animal; Dithiothreitol; Expectoran

2019
Fra2 Overexpression in Mice Leads to Non-allergic Asthma Development in an IL-13 Dependent Manner.
    Frontiers in immunology, 2018, Volume: 9

    Topics: Animals; Antibodies, Blocking; Asthma; Cell Proliferation; Cells, Cultured; Cytokines; Disease Model

2018
Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma.
    Chinese journal of integrative medicine, 2018, Volume: 24, Issue:12

    Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chemokines; Dis

2018
Pulmonary Neuroendocrine Cells Secrete γ-Aminobutyric Acid to Induce Goblet Cell Hyperplasia in Primate Models.
    American journal of respiratory cell and molecular biology, 2019, Volume: 60, Issue:6

    Topics: Acute Lung Injury; Animals; Asthma; Bronchi; Disease Models, Animal; Epithelial Cells; gamma-Aminobu

2019
S-Allyl cysteine reduces eosinophilic airway inflammation and mucus overproduction on ovalbumin-induced allergic asthma model.
    International immunopharmacology, 2019, Volume: 68

    Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage

2019
Bronchial Thermoplasty for Severe Asthma with Mucus Hypersecretion.
    Internal medicine (Tokyo, Japan), 2019, Jun-01, Volume: 58, Issue:11

    Topics: Asthma; Biopsy; Bronchi; Bronchial Thermoplasty; Bronchoscopy; Forced Expiratory Volume; Humans; Mal

2019
Increase in secreted airway mucins and partial Muc5b STAT6/FoxA2 regulation during Pneumocystis primary infection.
    Scientific reports, 2019, 02-14, Volume: 9, Issue:1

    Topics: Animals; Asthma; Epithelial Cells; Female; Hepatocyte Nuclear Factor 3-beta; Humans; Infant; Infant,

2019
SMAD Signaling Restricts Mucous Cell Differentiation in Human Airway Epithelium.
    American journal of respiratory cell and molecular biology, 2019, Volume: 61, Issue:3

    Topics: Asthma; Cell Differentiation; Epithelium; Goblet Cells; Humans; Lung; Metaplasia; Mucus; Respiratory

2019
CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma.
    Chest, 2019, Volume: 155, Issue:6

    Topics: Airway Management; Airway Obstruction; Asthma; Biomarkers; Correlation of Data; Eosinophils; Female;

2019
The receptor for advanced glycation end products is a critical mediator of type 2 cytokine signaling in the lungs.
    The Journal of allergy and clinical immunology, 2019, Volume: 144, Issue:3

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Cytokines; Epithelial Cells; Humans;

2019
Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
    Science (New York, N.Y.), 2019, 05-24, Volume: 364, Issue:6442

    Topics: Adaptive Immunity; Adjuvants, Immunologic; Animals; Asthma; Bronchial Hyperreactivity; Crystallizati

2019
Rho-kinase inhibitor attenuates airway mucus hypersecretion and inflammation partly by downregulation of IL-13 and the JNK1/2-AP1 signaling pathway.
    Biochemical and biophysical research communications, 2019, 08-20, Volume: 516, Issue:2

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Down-Regulation; Female; Infl

2019
ORMDL3 knockdown in the lungs alleviates airway inflammation and airway remodeling in asthmatic mice via JNK1/2-MMP-9 pathway.
    Biochemical and biophysical research communications, 2019, 08-27, Volume: 516, Issue:3

    Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Child; Disease Models, Animal; Fem

2019
Anti-inflammatory activity of SintMed65, an N-acylhydrazone derivative, in a mouse model of allergic airway inflammation.
    International immunopharmacology, 2019, Volume: 75

    Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage

2019
EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma.
    International journal of molecular medicine, 2013, Volume: 31, Issue:4

    Topics: Analysis of Variance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Eosinophilia; Female

2013
Dendritic polyglycerolsulfate near infrared fluorescent (NIRF) dye conjugate for non-invasively monitoring of inflammation in an allergic asthma mouse model.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Animals; Asthma; Disease Models, Animal; Female; Fluorescent Dyes; Glycerol; Immunoglobulin G; Infla

2013
Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Airway Remodeling; Aldehyde Reductase; Animals; Asthma; Biomarkers; Chronic Disease; Disease Models,

2013
Pinellia ternata Breitenbach attenuates ovalbumin-induced allergic airway inflammation and mucus secretion in a murine model of asthma.
    Immunopharmacology and immunotoxicology, 2013, Volume: 35, Issue:3

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease

2013
Dihydroartemisinin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model.
    Immunopharmacology and immunotoxicology, 2013, Volume: 35, Issue:3

    Topics: Animals; Anti-Asthmatic Agents; Artemisinins; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disea

2013
Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma.
    Respiratory medicine, 2013, Volume: 107, Issue:10

    Topics: Adolescent; Adult; Aged; Asthma; Chronic Disease; Cough; Cross-Sectional Studies; Forced Expiratory

2013
Thrombin promotes airway remodeling via protease-activated receptor-1 and transforming growth factor-β1 in ovalbumin-allergic rats.
    Inhalation toxicology, 2013, Volume: 25, Issue:10

    Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Collagen; Dose-Response Relationsh

2013
Tiotropium bromide inhibits relapsing allergic asthma in BALB/c mice.
    Pulmonary pharmacology & therapeutics, 2014, Volume: 27, Issue:1

    Topics: Airway Remodeling; Animals; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Dexamethasone;

2014
Effects of montelukast on subepithelial/peribronchial fibrosis in a murine model of ovalbumin induced chronic asthma.
    International immunopharmacology, 2013, Volume: 17, Issue:3

    Topics: Acetates; Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cycloprop

2013
Mast cell-deficient kit mice develop house dust mite-induced lung inflammation despite impaired eosinophil recruitment.
    Journal of innate immunity, 2014, Volume: 6, Issue:2

    Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Chemokine CCL11; Disease Models, Animal; E

2014
Early-life exposure to combustion-derived particulate matter causes pulmonary immunosuppression.
    Mucosal immunology, 2014, Volume: 7, Issue:3

    Topics: Adoptive Transfer; Allergens; Animals; Animals, Newborn; Antigens; Asthma; Dendritic Cells; Disease

2014
Naringenin inhibits allergen‑induced airway remodeling in a murine model of asthma.
    Molecular medicine reports, 2014, Volume: 9, Issue:4

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flu

2014
Bangpungtongseong-san, a traditional herbal medicine, attenuates chronic asthmatic effects induced by repeated ovalbumin challenge.
    International journal of molecular medicine, 2014, Volume: 33, Issue:4

    Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Chemokine CC

2014
Interleukin-13-induced MUC5AC expression is regulated by a PI3K-NFAT3 pathway in mouse tracheal epithelial cells.
    Biochemical and biophysical research communications, 2014, Mar-28, Volume: 446, Issue:1

    Topics: Animals; Asthma; Cells, Cultured; Chloride Channels; Chromones; Cyclosporine; Hepatocyte Nuclear Fac

2014
Th2-type cytokine-induced mucus metaplasia decreases susceptibility of human bronchial epithelium to rhinovirus infection.
    American journal of respiratory cell and molecular biology, 2014, Volume: 51, Issue:2

    Topics: Adult; Airway Remodeling; Asthma; Bronchi; Case-Control Studies; Cells, Cultured; Cytokines; Disease

2014
Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma.
    American journal of respiratory and critical care medicine, 2014, Apr-15, Volume: 189, Issue:8

    Topics: Asthma; Case-Control Studies; Cytokines; Disease Progression; Eosinophils; GPI-Linked Proteins; Huma

2014
Protective effects of the polyphenol sesamin on allergen-induced T(H)2 responses and airway inflammation in mice.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Active Transport, Cell Nucleus; Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents;

2014
Treatment with the C5a receptor/CD88 antagonist PMX205 reduces inflammation in a murine model of allergic asthma.
    International immunopharmacology, 2014, Volume: 21, Issue:2

    Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models,

2014
Respiratory disease in United States farmers.
    Occupational and environmental medicine, 2014, Volume: 71, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Agriculture; Air Pollutants; Asthma; Cough; Female; Humans; Iowa; Ma

2014
[Effects of inhaled LPS on inflammation and mucus hypersecretion in the airway of asthmatic mice].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2014, Volume: 45, Issue:3

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Inflammation; Interleukin-4; Lipopolysaccharides; Lun

2014
Siegesbeckia glabrescens attenuates allergic airway inflammation in LPS-stimulated RAW 264.7 cells and OVA induced asthma murine model.
    International immunopharmacology, 2014, Volume: 22, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Cel

2014
No adjuvant effect of Bacillus thuringiensis-maize on allergic responses in mice.
    PloS one, 2014, Volume: 9, Issue:8

    Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Asthma; Bacillus thuringiensis; Female; Hyperse

2014
Pdcd4 modulates markers of macrophage alternative activation and airway remodeling in antigen-induced pulmonary inflammation.
    Journal of leukocyte biology, 2014, Volume: 96, Issue:6

    Topics: Airway Remodeling; Animals; Apoptosis Regulatory Proteins; Arginase; Asthma; beta-N-Acetylhexosamini

2014
Airway remodeling is reversed by aerobic training in a murine model of chronic asthma.
    Scandinavian journal of medicine & science in sports, 2015, Volume: 25, Issue:3

    Topics: Airway Remodeling; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Cell Movement; Chemokine

2015
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
    Immunobiology, 2014, Volume: 219, Issue:12

    Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod

2014
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
    Immunobiology, 2014, Volume: 219, Issue:12

    Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod

2014
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
    Immunobiology, 2014, Volume: 219, Issue:12

    Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod

2014
Melatonin reduces airway inflammation in ovalbumin-induced asthma.
    Immunobiology, 2014, Volume: 219, Issue:12

    Topics: Animals; Antibody Formation; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Disease Mod

2014
Mucus plugging mimicking a left hilar mass.
    British journal of hospital medicine (London, England : 2005), 2014, Volume: 75, Issue:9

    Topics: Airway Obstruction; Asthma; Diagnosis, Differential; Humans; Lung; Lung Neoplasms; Male; Middle Aged

2014
Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.
    Respirology (Carlton, Vic.), 2015, Volume: 20, Issue:2

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Disease Models, Animal; Eosino

2015
Serotonin 5-HT₂ receptor activation prevents allergic asthma in a mouse model.
    American journal of physiology. Lung cellular and molecular physiology, 2015, Jan-15, Volume: 308, Issue:2

    Topics: 5-Hydroxytryptophan; Amphetamines; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactiv

2015
Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-κB in a murine model of asthma.
    Molecular immunology, 2015, Volume: 64, Issue:1

    Topics: Airway Remodeling; Animals; Asthma; Blotting, Western; Bronchi; Bronchoalveolar Lavage Fluid; Diseas

2015
No direct association between asthma and the microbiome based on currently available techniques.
    Medicine, 2014, Volume: 93, Issue:27

    Topics: Adult; Aged; Aged, 80 and over; Asthma; Female; Humans; Male; Microbiota; Middle Aged; Mucus; Respir

2014
Occupational sensitization to African penguin serum and mucus proteins.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2015, Volume: 114, Issue:4

    Topics: Adult; Allergens; Animals; Asthma; Blood Proteins; Bronchial Spasm; Cross Reactions; Female; Fenoter

2015
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.
    Nature communications, 2015, Feb-17, Volume: 6

    Topics: Allergens; Animals; Aspergillus oryzae; Asthma; Bronchial Hyperreactivity; Female; Immunohistochemis

2015
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.
    Nature communications, 2015, Feb-17, Volume: 6

    Topics: Allergens; Animals; Aspergillus oryzae; Asthma; Bronchial Hyperreactivity; Female; Immunohistochemis

2015
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.
    Nature communications, 2015, Feb-17, Volume: 6

    Topics: Allergens; Animals; Aspergillus oryzae; Asthma; Bronchial Hyperreactivity; Female; Immunohistochemis

2015
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.
    Nature communications, 2015, Feb-17, Volume: 6

    Topics: Allergens; Animals; Aspergillus oryzae; Asthma; Bronchial Hyperreactivity; Female; Immunohistochemis

2015
Distal airways are protected from goblet cell metaplasia by diminished expression of IL-13 signalling components.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2015, Volume: 45, Issue:9

    Topics: Animals; Asthma; Female; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Re

2015
The Flavonoid 7,4'-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-κB, STAT6, and HDAC2.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:6

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Disease Models, Animal; Epithelial Cells;

2015
The sickle cell mouse lung: proinflammatory and primed for allergic inflammation.
    Translational research : the journal of laboratory and clinical medicine, 2015, Volume: 166, Issue:3

    Topics: Anemia, Sickle Cell; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytok

2015
Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process.
    International immunopharmacology, 2015, Volume: 26, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Cordyceps; Cytokines; Deoxyade

2015
The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation.
    BMC complementary and alternative medicine, 2015, Jun-06, Volume: 15

    Topics: Allergens; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage F

2015
Exposure to Deepwater Horizon Crude Oil Burnoff Particulate Matter Induces Pulmonary Inflammation and Alters Adaptive Immune Response.
    Environmental science & technology, 2015, Jul-21, Volume: 49, Issue:14

    Topics: Adaptive Immunity; Animals; Asthma; Cell Death; Cell Line; Cell Survival; Dinoprost; Disease Models,

2015
SP600125 promotes resolution of allergic airway inflammation via TLR9 in an OVA-induced murine acute asthma model.
    Molecular immunology, 2015, Volume: 67, Issue:2 Pt B

    Topics: Acute Disease; Animals; Anthracenes; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Di

2015
PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.
    Journal of translational medicine, 2015, Jul-14, Volume: 13

    Topics: Adoptive Transfer; Animals; Antigens, CD; Asthma; Bronchial Hyperreactivity; CD4-Positive T-Lymphocy

2015
Rho-kinase inhibitor fasudil reduces allergic airway inflammation and mucus hypersecretion by regulating STAT6 and NFκB.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2015, Volume: 45, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Allergens; Animals; Asthma; Case-Control Studies; Cel

2015
[Effects of ozone oxidative stress on the airway hyperresponsiveness and mucus production in mice with acute allergic airway inflammation].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2015, Volume: 38, Issue:3

    Topics: Animals; Asthma; Bronchoalveolar Lavage; Disease Models, Animal; Female; Inflammation; Interleukin-1

2015
Glucagon Like Peptide-1 (GLP-1) Modulates OVA-Induced Airway Inflammation and Mucus Secretion Involving a Protein Kinase A (PKA)-Dependent Nuclear Factor-κB (NF-κB) Signaling Pathway in Mice.
    International journal of molecular sciences, 2015, Aug-26, Volume: 16, Issue:9

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cyclic AMP-Dependent Protein Kinases; Cytokines; Dise

2015
Copper oxide nanoparticles aggravate airway inflammation and mucus production in asthmatic mice via MAPK signaling.
    Nanotoxicology, 2016, Volume: 10, Issue:4

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Copper; Cytokines; Disease Models, Animal

2016
Resveratrol inhibits mucus overproduction and MUC5AC expression in a murine model of asthma.
    Molecular medicine reports, 2016, Volume: 13, Issue:1

    Topics: Animals; Asthma; Cell Line; Disease Models, Animal; Epithelial Cells; Female; Gene Expression Regula

2016
[Improvement of Awareness and Diagnosis for Chronic Obstructive Pulmonary Disease (COPD) by General Physician. Topics: II. Diagnosis of COPD in primary care physicians].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2015, Jun-10, Volume: 104, Issue:6

    Topics: Asthma; Cough; Diagnosis, Differential; Humans; Mucus; Physicians, Primary Care; Pulmonary Disease,

2015
Continuous Exposure to Low-Dose-Rate Gamma Irradiation Reduces Airway Inflammation in Ovalbumin-Induced Asthma.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Choline; Disease Models,

2015
Decreased Bronchial Eosinophilic Inflammation and Mucus Hypersecretion in Asthmatic Mice Lacking All Nitric Oxide Synthase Isoforms.
    Lung, 2016, Volume: 194, Issue:1

    Topics: Animals; Asthma; Bronchitis; Chemokine CCL11; Chemokine CCL17; Chemokine CCL2; Cytokines; Eosinophil

2016
Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation.
    Journal of immunology (Baltimore, Md. : 1950), 2016, Feb-01, Volume: 196, Issue:3

    Topics: Adoptive Transfer; Animals; Asthma; Disease Models, Animal; Drug Resistance; Immunoblotting; Interle

2016
Kinin B1 receptor antagonist BI113823 reduces allergen-induced airway inflammation and mucus secretion in mice.
    Pharmacological research, 2016, Volume: 104

    Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bradykinin B1 Receptor Antagonists; Bronchoalv

2016
Suhuang antitussive capsule at lower doses attenuates airway hyperresponsiveness, inflammation, and remodeling in a murine model of chronic asthma.
    Scientific reports, 2016, Feb-10, Volume: 6

    Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal;

2016
Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice.
    American journal of respiratory cell and molecular biology, 2016, Volume: 55, Issue:2

    Topics: Adrenergic beta-2 Receptor Agonists; Aminopyridines; Animals; Asthma; Benzamides; Bronchial Hyperrea

2016
Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma.
    The American journal of Chinese medicine, 2016, Volume: 44, Issue:1

    Topics: Administration, Oral; Animals; Anti-Asthmatic Agents; Asthma; Cytokines; Disease Models, Animal; Dos

2016
Recombinant human deoxyribonuclease therapy improves airway resistance and reduces DNA extracellular traps in a murine acute asthma model.
    Experimental lung research, 2016, Volume: 42, Issue:2

    Topics: Administration, Intranasal; Airway Obstruction; Airway Resistance; Allergens; Animals; Asthma; Bronc

2016
Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma.
    The Journal of clinical investigation, 2016, 06-01, Volume: 126, Issue:6

    Topics: Airway Obstruction; Asthma; Case-Control Studies; Gels; Humans; Mucin 5AC; Mucin-5B; Mucociliary Cle

2016
Cylindromatosis (Cyld) gene mutation in T cells promotes the development of an IL-9-dependent allergic phenotype in experimental asthma.
    Cellular immunology, 2016, Volume: 308

    Topics: Animals; Asthma; CD4-Positive T-Lymphocytes; Deubiquitinating Enzyme CYLD; Eosinophils; Humans; Hype

2016
Pentraxin 3 deletion aggravates allergic inflammation through a T
    The Journal of allergy and clinical immunology, 2017, Volume: 139, Issue:3

    Topics: Adult; Aged; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; C-Reactive Protein; CD4-Posit

2017
Luteolin Attenuates Airway Mucus Overproduction via Inhibition of the GABAergic System.
    Scientific reports, 2016, 09-06, Volume: 6

    Topics: A549 Cells; Animals; Anti-Asthmatic Agents; Asthma; Bronchi; GABA-A Receptor Antagonists; Goblet Cel

2016
Astragalus polysaccharide modulates ER stress response in an OVA-LPS induced murine model of severe asthma.
    International journal of biological macromolecules, 2016, Volume: 93, Issue:Pt A

    Topics: Active Transport, Cell Nucleus; Animals; Anti-Asthmatic Agents; Asthma; Astragalus Plant; Endoplasmi

2016
IFN-γ Blocks Development of an Asthma Phenotype in Rhinovirus-Infected Baby Mice by Inhibiting Type 2 Innate Lymphoid Cells.
    American journal of respiratory cell and molecular biology, 2017, Volume: 56, Issue:2

    Topics: Animals; Animals, Newborn; Asthma; Cell Lineage; Epithelial Cells; Gene Expression Regulation; HeLa

2017
Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.
    Science translational medicine, 2016, 10-05, Volume: 8, Issue:359

    Topics: Adult; Allergens; Asthma; Cytokines; Humans; Hypersensitivity; Inflammation; Lung; Mucus; Muscle, Sm

2016
Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.
    American journal of respiratory and critical care medicine, 2016, 11-15, Volume: 194, Issue:10

    Topics: Adult; Asthma; Female; Gene Expression; Humans; Male; Middle Aged; Mucin 5AC; Mucin-5B; Mucus

2016
IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models.
    Allergy, 2017, Volume: 72, Issue:7

    Topics: Allergens; Animals; Asthma; Blood Cells; Cytokines; Dermatophagoides pteronyssinus; Disease Models,

2017
Reduced allergic lung inflammation by root extracts from two species of Peucedanum through inhibition of Th2 cell activation.
    Journal of ethnopharmacology, 2017, Jan-20, Volume: 196

    Topics: Allergens; Animals; Anti-Asthmatic Agents; Apiaceae; Asthma; Bronchoalveolar Lavage Fluid; CD4-Posit

2017
Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma.
    EBioMedicine, 2017, Volume: 15

    Topics: Animals; Asthma; Biomarkers; Case-Control Studies; Cytokines; Disease Models, Animal; Endoplasmic Re

2017
Unusual Mucus Impaction in an Adolescent Patient With Severe Asthma.
    Clinical pediatrics, 2017, Volume: 56, Issue:14

    Topics: Adolescent; Asthma; Bronchoscopy; Glucocorticoids; Humans; Lung; Male; Mucus; Nitric Oxide; Pulmonar

2017
Attenuated airway hyperresponsiveness and mucus secretion in HDM-exposed Igf1r-deficient mice.
    Allergy, 2017, Volume: 72, Issue:9

    Topics: Animals; Asthma; Eosinophils; Female; Insulin-Like Growth Factor I; Mice; Mucus; Pyroglyphidae; Resp

2017
Depletion of CD8+ T cells enhances airway remodelling in a rodent model of asthma.
    Immunology, 2009, Volume: 126, Issue:1

    Topics: Allergens; Animals; Antibodies, Monoclonal; Asthma; Bronchoalveolar Lavage Fluid; CD8 Antigens; CD8-

2009
Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma.
    Canadian journal of physiology and pharmacology, 2008, Volume: 86, Issue:7

    Topics: Actins; Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Ch

2008
GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice.
    Biochemical and biophysical research communications, 2008, Sep-26, Volume: 374, Issue:3

    Topics: Administration, Intranasal; Animals; Antigens; Asthma; Benzoates; Cell Differentiation; I-kappa B Pr

2008
CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling.
    The Journal of allergy and clinical immunology, 2008, Volume: 122, Issue:3

    Topics: Adoptive Transfer; Allergens; Animals; Asthma; Cell Separation; Collagen; Eosinophils; Female; Immun

2008
Novel triple neurokinin receptor antagonist CS-003 inhibits respiratory disease models in guinea pigs.
    European journal of pharmacology, 2008, Oct-31, Volume: 596, Issue:1-3

    Topics: Administration, Oral; Animals; Asthma; Bronchoconstriction; Capillary Permeability; Capsaicin; Cough

2008
Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells.
    Clinical immunology (Orlando, Fla.), 2008, Volume: 129, Issue:2

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Movement; Cell Polarity; Cytokines; Dendritic Ce

2008
Endothelin A receptor antagonist modulates lymphocyte and eosinophil infiltration, hyperreactivity and mucus in murine asthma.
    International immunopharmacology, 2008, Dec-20, Volume: 8, Issue:13-14

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; En

2008
[Plastic bronchitis: report of a pediatric case].
    Revue de pneumologie clinique, 2008, Volume: 64, Issue:5

    Topics: Asthma; Bronchi; Bronchitis; Bronchoscopy; Child, Preschool; Croup; Follow-Up Studies; Humans; Male;

2008
Inhibitory effect of kefiran on ovalbumin-induced lung inflammation in a murine model of asthma.
    Archives of pharmacal research, 2008, Volume: 31, Issue:12

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Fem

2008
Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthma.
    International immunopharmacology, 2009, Volume: 9, Issue:4

    Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchoalveolar Lav

2009
A novel (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]chromen-3-yl-ester, inhibits ovalbumin-induced lung inflammation in a mouse model of asthma.
    Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:3

    Topics: Acrylates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Benzopyrans; Butyrates; Chroman

2009
Different doses of lipopolysaccharides regulate the lung inflammation of asthmatic mice via TLR4 pathway in alveolar macrophages.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2009, Volume: 46, Issue:3

    Topics: Animals; Asthma; Dose-Response Relationship, Drug; Eosinophils; Female; Inflammation; Interferon-gam

2009
Irreversiblity of remodeled features on high-resolution computerized tomography scans of asthmatic patients on conventional therapy: a 6-year longitudinal study.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2009, Volume: 46, Issue:3

    Topics: Adult; Anti-Asthmatic Agents; Asthma; Bronchi; Female; Humans; Lung; Male; Middle Aged; Mucus; Prosp

2009
Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma.
    International immunology, 2009, Volume: 21, Issue:6

    Topics: Airway Obstruction; Allergens; Animals; Apoptosis; Asthma; Cell Adhesion; Cytokines; Disease Models,

2009
Environmental tobacco smoke exposure does not prevent corticosteroids reducing inflammation, remodeling, and airway hyperreactivity in mice exposed to allergen.
    American journal of physiology. Lung cellular and molecular physiology, 2009, Volume: 297, Issue:2

    Topics: Adrenal Cortex Hormones; Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Disease Mod

2009
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.
    American journal of respiratory and critical care medicine, 2009, Oct-01, Volume: 180, Issue:7

    Topics: Animals; Asthma; Disease Models, Animal; Epithelial Cells; Gene Expression; Hepatocyte Nuclear Facto

2009
Preventive and curative glycoside kaempferol treatments attenuate the TH2-driven allergic airway disease.
    International immunopharmacology, 2009, Volume: 9, Issue:13-14

    Topics: Animals; Antigens, CD; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Disaccharides; Eosinophils;

2009
Anti-inflammatory and anti-asthmatic effects of Viola mandshurica W. Becker (VM) ethanolic (EtOH) extract on airway inflammation in a mouse model of allergic asthma.
    Journal of ethnopharmacology, 2010, Jan-08, Volume: 127, Issue:1

    Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchi; Bronchial

2010
Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice.
    Phytotherapy research : PTR, 2010, Volume: 24, Issue:5

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chemokine CCL5; Disease Mo

2010
Does milk increase mucus production?
    Medical hypotheses, 2010, Volume: 74, Issue:4

    Topics: Animals; Asthma; Endorphins; Gastrointestinal Tract; Goblet Cells; Humans; Milk; Mucus; Peptide Frag

2010
Increased myoepithelial cells of bronchial submucosal glands in fatal asthma.
    Thorax, 2010, Volume: 65, Issue:1

    Topics: Adult; Asthma; Autopsy; Bronchi; Epithelial Cells; Exocrine Glands; Female; Humans; Male; Middle Age

2010
Intranasal CpG therapy attenuated experimental fungal asthma in a TLR9-dependent and -independent manner.
    International archives of allergy and immunology, 2010, Volume: 152, Issue:2

    Topics: Adjuvants, Immunologic; Administration, Intranasal; Animals; Aspergillus fumigatus; Asthma; Bronchia

2010
Helminth infection inhibits airway allergic reaction and dendritic cells are involved in the modulation process.
    Parasite immunology, 2010, Volume: 32, Issue:1

    Topics: Adoptive Transfer; Animals; Asthma; Bronchial Hyperreactivity; Dendritic Cells; Eosinophilia; Female

2010
The plant extract Isatis tinctoria L. extract (ITE) inhibits allergen-induced airway inflammation and hyperreactivity in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Volume: 17, Issue:8-9

    Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lav

2010
Protective effects of allantoin against ovalbumin (OVA)-induced lung inflammation in a murine model of asthma.
    International immunopharmacology, 2010, Volume: 10, Issue:4

    Topics: Alanine Transaminase; Allantoin; Animals; Aspartate Aminotransferases; Asthma; Bronchoalveolar Lavag

2010
Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma.
    Journal of immunology (Baltimore, Md. : 1950), 2010, Apr-15, Volume: 184, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Aged; Animals; Arthritis, Experimental; Ast

2010
Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen.
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:11

    Topics: Air Pollutants; Allergens; Animals; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchoalveolar L

2010
Allergic airway inflammation induces a pro-secretory epithelial ion transport phenotype in mice.
    The European respiratory journal, 2010, Volume: 36, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Allergens; Amiloride; Animals; Aspergillus fumigatus; Asthma; Bronchoal

2010
The overexpression of heparin-binding epidermal growth factor is responsible for Th17-induced airway remodeling in an experimental asthma model.
    Journal of immunology (Baltimore, Md. : 1950), 2010, Jul-15, Volume: 185, Issue:2

    Topics: Adoptive Transfer; Airway Remodeling; Animals; Antibodies, Monoclonal; Asthma; Blotting, Western; Cy

2010
Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice.
    Journal of cellular and molecular medicine, 2011, Volume: 15, Issue:6

    Topics: Animals; Antigens; Aquaporin 5; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Gene Deletion; Hype

2011
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma.
    American journal of respiratory cell and molecular biology, 2011, Volume: 44, Issue:4

    Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Flui

2011
Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model.
    International journal of molecular medicine, 2010, Volume: 26, Issue:2

    Topics: Analysis of Variance; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokine

2010
Anti-inflammatory effects of ethanolic extract from Lagerstroemia indica on airway inflammation in mice.
    Journal of ethnopharmacology, 2011, Jul-14, Volume: 136, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Line; Cytokines; Eosin

2011
Chronic mucus hypersecretion: prevalence and risk factors in younger individuals.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2010, Volume: 14, Issue:8

    Topics: Adolescent; Adult; Age Factors; Asthma; Child; Denmark; Diseases in Twins; Female; Humans; Male; Muc

2010
Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-κB inhibition.
    Journal of ethnopharmacology, 2011, Jul-14, Volume: 136, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Biological Transport; Bronchoalveolar Lavage Fluid; Cell

2011
Anti-asthmatic effects of an Amomum compactum extract on an ovalbumin (OVA)-induced murine asthma model.
    Bioscience, biotechnology, and biochemistry, 2010, Volume: 74, Issue:9

    Topics: Amomum; Animals; Asthma; Dose-Response Relationship, Drug; Eosinophils; Immunoglobulin E; Immunologi

2010
Effects of astragaloside IV on IFN-gamma level and prolonged airway dysfunction in a murine model of chronic asthma.
    Planta medica, 2011, Volume: 77, Issue:4

    Topics: Animals; Asthma; Astragalus Plant; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chronic

2011
A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma.
    The Journal of allergy and clinical immunology, 2011, Volume: 127, Issue:1

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Separation; Enzyme-Linked Immunosorbent Assay; F

2011
Inhibition of airway inflammation, hyperresponsiveness and remodeling by soy isoflavone in a murine model of allergic asthma.
    International immunopharmacology, 2011, Volume: 11, Issue:8

    Topics: Airway Remodeling; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chemoki

2011
Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling.
    International immunopharmacology, 2011, Volume: 11, Issue:8

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchi; Collagen; Eosinophils; Extracellular Matrix

2011
Prostanoid DP receptor antagonists suppress symptomatic asthma-like manifestation by distinct actions from a glucocorticoid in rats.
    European journal of pharmacology, 2011, Volume: 666, Issue:1-3

    Topics: Acetylcholine; Aged; Animals; Antigens; Asthma; Bronchial Hyperreactivity; Chemokines; Female; Gene

2011
Flow cytometry of sputum: assessing inflammation and immune response elements in the bronchial airways.
    Inhalation toxicology, 2011, Volume: 23, Issue:7

    Topics: Asthma; B-Lymphocytes; Biomarkers; Bronchi; Dendritic Cells; Eosinophils; Epithelial Cells; Flow Cyt

2011
Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor.
    The Journal of biological chemistry, 2011, Aug-12, Volume: 286, Issue:32

    Topics: Allergens; Animals; Asthma; Disease Models, Animal; Enzyme Inhibitors; Gene Knock-In Techniques; Gro

2011
Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway.
    PloS one, 2011, Volume: 6, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antimalarials; Artemisinins; Artesunate; Asthma; Bronchi; Broncho

2011
STAT6 links IL-4/IL-13 stimulation with pendrin expression in asthma and chronic obstructive pulmonary disease.
    Clinical pharmacology and therapeutics, 2011, Volume: 90, Issue:3

    Topics: Asthma; Base Pairing; Binding Sites; Cell Line; Epithelial Cells; Gene Expression Regulation; Humans

2011
Environmental tobacco smoke and progesterone alter lung inflammation and mucous metaplasia in a mouse model of allergic airway disease.
    Clinical reviews in allergy & immunology, 2012, Volume: 43, Issue:1-2

    Topics: Allergens; Animals; Asthma; Disease Models, Animal; Female; Humans; Hypersensitivity, Immediate; Mal

2012
The role of SPINK5 in asthma related physiological events in the airway epithelium.
    Respiratory medicine, 2012, Volume: 106, Issue:3

    Topics: Apoptosis; Asthma; Cell Survival; Cells, Cultured; Cytokines; Epithelial Cells; Genetic Vectors; Hum

2012
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals.
    Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2

    Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An

2012
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals.
    Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2

    Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An

2012
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals.
    Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2

    Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An

2012
Effect of verapamil on bronchial goblet cells of asthma: an experimental study on sensitized animals.
    Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2

    Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Calcium Channel Blockers; Disease Models, An

2012
Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.
    European journal of pharmacology, 2012, Mar-15, Volume: 679, Issue:1-3

    Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Adhesion Molecules; Cell Coun

2012
Milk consumption and mucus production in children with asthma.
    Canadian family physician Medecin de famille canadien, 2012, Volume: 58, Issue:2

    Topics: Animals; Asthma; Child; Humans; Milk; Mucus

2012
Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation.
    Immunity, 2012, Mar-23, Volume: 36, Issue:3

    Topics: Adoptive Transfer; Allergens; Animals; Asthma; Cytokines; Disease Models, Animal; Gene Expression Pr

2012
Components of Streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells.
    Journal of immunology (Baltimore, Md. : 1950), 2012, May-01, Volume: 188, Issue:9

    Topics: Adoptive Transfer; Animals; Asthma; Bacterial Capsules; Bacterial Proteins; Disease Models, Animal;

2012
CD137 deficiency does not affect development of airway inflammation or respiratory tolerance induction in murine models.
    Clinical and experimental immunology, 2012, Volume: 168, Issue:3

    Topics: Allergens; Animals; Asthma; Cytokines; Disease Models, Animal; Eosinophils; Humans; Immune Tolerance

2012
IL-17A and IL-25: therapeutic targets for allergic and exacerbated asthmatic disease.
    Future medicinal chemistry, 2012, Volume: 4, Issue:7

    Topics: Allergens; Asthma; Disease Progression; Humans; Hypersensitivity; Interleukin-17; Lung; Molecular Ta

2012
Rosuvastatin attenuates mucus secretion in a murine model of chronic asthma by inhibiting the gamma-aminobutyric acid type A receptor.
    Chinese medical journal, 2012, Volume: 125, Issue:8

    Topics: Animals; Asthma; Chronic Disease; Disease Models, Animal; Female; Fluorobenzenes; GABA-A Receptor An

2012
Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers.
    BMC medical genomics, 2012, Jun-07, Volume: 5

    Topics: Adult; Asthma; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networ

2012
Effects and mechanism of arsenic trioxide on reversing the asthma pathologies including Th17-IL-17 axis in a mouse model.
    Iranian journal of allergy, asthma, and immunology, 2012, Volume: 11, Issue:2

    Topics: Animals; Anti-Asthmatic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Asthma; Bronchial Hyperreac

2012
Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma.
    Anesthesiology, 2012, Volume: 117, Issue:3

    Topics: Anesthetics, Local; Animals; Asthma; Bronchi; Disease Models, Animal; Fibrosis; GATA3 Transcription

2012
SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:10

    Topics: 3' Untranslated Regions; Airway Obstruction; Animals; Antiporters; Asthma; Bronchitis; Calcium; Chil

2012
PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production.
    Mucosal immunology, 2013, Volume: 6, Issue:4

    Topics: Allergens; Animals; Antibodies, Monoclonal; Asthma; Bronchial Hyperreactivity; Dendritic Cells; Gene

2013
The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunoglobulin E;

2012
Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice.
    American journal of respiratory cell and molecular biology, 2013, Volume: 48, Issue:3

    Topics: Animals; Antigens, Dermatophagoides; Asthma; Complement Activation; Cytokines; Disease Models, Anima

2013
Tripterygium polyglycosid attenuates the established airway inflammation in asthmatic mice.
    Chinese journal of integrative medicine, 2013, Volume: 19, Issue:4

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Dexamethasone;

2013
[The cutting-edge of medicine; Management and therapy for airway mucus hypersecretion].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2012, Dec-10, Volume: 101, Issue:12

    Topics: Asthma; Bronchiolitis Obliterans; Cystic Fibrosis; Humans; Mucus; Pulmonary Disease, Chronic Obstruc

2012
Effect of dexamethasone on expression of AGR2 protein in asthmatic mice.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2013, Volume: 33, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Dexamethasone; Female; Interleukin-13; Lung; Mice; Mice,

2013
Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma.
    Thorax, 2002, Volume: 57, Issue:8

    Topics: Adult; Asthma; Autopsy; Case-Control Studies; Cell Count; Cell Degranulation; Exocrine Glands; Femal

2002
Long-lived Th2 memory in experimental allergic asthma.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Nov-01, Volume: 169, Issue:9

    Topics: Acute Disease; Aerosols; Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Female; Immunoglobul

2002
A small molecule inhibitor of redox-regulated NF-kappa B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Nov-01, Volume: 169, Issue:9

    Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar L

2002
Mucus hypersecretion in respiratory disease. Chair's introduction.
    Novartis Foundation symposium, 2002, Volume: 248

    Topics: Animals; Asthma; Chloride Channels; Exocytosis; Humans; Inflammation; Lymphokines; Mice; Mucus; Pulm

2002
Cytokine regulation of mucus production in a model of allergic asthma.
    Novartis Foundation symposium, 2002, Volume: 248

    Topics: Administration, Inhalation; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Exocytos

2002
Bronchial asthma--"the plumbing".
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2003, Volume: 40 Suppl

    Topics: Asthma; Bronchial Hyperreactivity; Humans; Lung; Mucus; Muscle, Smooth; Risk Factors

2003
Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses asthma-like responses via nitric oxide synthase 2 activity.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Jul-15, Volume: 171, Issue:2

    Topics: Administration, Inhalation; Allergens; Animals; Anti-Allergic Agents; Asthma; Bronchi; Bronchial Hyp

2003
Characterization of airway plugging in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Adolescent; Adult; Aged; Airway Obstruction; Asthma; Bronchi; Cell Culture Techniques; Child; Humans

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
The role of mucus in fatal asthma.
    The American journal of medicine, 2003, Volume: 115, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchi; Humans; Mucins; Mucus; Muscle, Smooth

2003
[Mucous plugs of the bronchis in patients with asthma and Hoffman and Teichmuller's eosinophilic catarrh].
    El Dia medico, 1956, Sep-10, Volume: 28, Issue:65

    Topics: Asthma; Bronchi; Bronchial Diseases; Common Cold; Disease; Eosinophilia; Humans; Mucus

1956
[Mucous plugs of the bronchis in patients with asthma and Hoffman and Teichmuller's eosinophilic catarrh].
    El Dia medico, 1956, Sep-10, Volume: 28, Issue:65

    Topics: Asthma; Bronchi; Bronchial Diseases; Common Cold; Disease; Eosinophilia; Humans; Mucus

1956
[Mucous plugs of the bronchis in patients with asthma and Hoffman and Teichmuller's eosinophilic catarrh].
    El Dia medico, 1956, Sep-10, Volume: 28, Issue:65

    Topics: Asthma; Bronchi; Bronchial Diseases; Common Cold; Disease; Eosinophilia; Humans; Mucus

1956
[Mucous plugs of the bronchis in patients with asthma and Hoffman and Teichmuller's eosinophilic catarrh].
    El Dia medico, 1956, Sep-10, Volume: 28, Issue:65

    Topics: Asthma; Bronchi; Bronchial Diseases; Common Cold; Disease; Eosinophilia; Humans; Mucus

1956
[Mucous plugs of bronchi in asthma & Hoffmann & Teichmüller eosinophilic catarrhs].
    Revista brasileira de medicina, 1957, Volume: 14, Issue:4

    Topics: Asthma; Bronchi; Common Cold; Humans; Mucus; Pulmonary Eosinophilia; Respiratory Tract Diseases

1957
[Results in aspiration of mucus & hyaluronidase-hydrocortisone aerosol therapy of bronchial asthma].
    Acta allergologica. Supplementum, 1958, Volume: 5

    Topics: Aerosols; Asthma; Humans; Hyaluronoglucosaminidase; Hydrocortisone; Mucus

1958
[Therapy of bronchial asthma by mucus drainage and hyaluronidase-hydrocortisone-prednisone aerosol].
    Orvosi hetilap, 1958, Feb-02, Volume: 99, Issue:5

    Topics: Aerosols; Asthma; Body Fluids; Drainage; Humans; Hyaluronoglucosaminidase; Hydrocortisone; Mucus; Pr

1958
[The action of cortisone-like substances on the secretion of bronchial mucus in asthma].
    Journal francais de medecine et chirurgie thoraciques, 1963, Volume: 17

    Topics: Adrenal Cortex Hormones; Asthma; Bronchi; Cortisone; Humans; Mucus; Respiratory System

1963
[THE GLYCOPROTEINS OF BRONCHIAL SECRETIONS].
    Exposes annuels de biochimie medicale, 1963, Volume: 24

    Topics: Antibodies; Asthma; Beta-Globulins; Blood Group Antigens; Bronchitis; Chromatography; Chymotrypsin;

1963
MUCOID IMPACTION OF THE BRONCHI.
    Australasian annals of medicine, 1964, Volume: 13

    Topics: Asthma; Blood Cell Count; Bronchi; Bronchial Diseases; Bronchitis; Bronchoscopy; Humans; Hypersensit

1964
MUCOID IMPACTION OF THE BRONCHI.
    The British journal of radiology, 1964, Volume: 37

    Topics: Asthma; Bronchi; Bronchial Diseases; Bronchiectasis; Bronchoscopy; Humans; Mucus; Pulmonary Atelecta

1964
NEW MUCOLYTIC AGENTS FOR SPUTUM LIQUEFACTION.
    Postgraduate medicine, 1964, Volume: 36

    Topics: Acetylcysteine; Asthma; Bronchial Diseases; Cysteine; Cystic Fibrosis; Expectorants; Fibrin; Humans;

1964
BRONCHOSCOPIC LAVAGE IN BRONCHIAL ASTHMA.
    IMJ. Illinois medical journal, 1965, Volume: 127

    Topics: Asthma; Bronchoalveolar Lavage; Bronchoscopy; Humans; Mucus; Therapeutic Irrigation; Therapeutics

1965
ASTHMA AND COUGHING.
    Marquette medical review, 1965, Volume: 31

    Topics: Asthma; Cough; Humans; Mucus; Therapeutics

1965
HISTOCHEMICAL AND ENZYME STUDIES OF BRONCHIAL MUCUS.
    Medicina thoracalis, 1965, Volume: 22

    Topics: Asthma; Bronchi; Bronchitis; Cystic Fibrosis; Glycosaminoglycans; Histocytochemistry; Humans; Mucous

1965
THE SPUTUM IN BRONCHIAL ASTHMA: PATHOGNOMONIC PATTERNS.
    The Journal of pathology and bacteriology, 1965, Volume: 89

    Topics: Asthma; Bronchial Diseases; Cell Aggregation; Diagnosis, Differential; Eosinophils; Humans; Leukocyt

1965
Mucus and fatal asthma.
    The American journal of medicine, 2004, Jan-01, Volume: 116, Issue:1

    Topics: Airway Obstruction; Asthma; Cell Count; Goblet Cells; Humans; Mucin 5AC; Mucin-5B; Mucins; Mucus; Re

2004
A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma.
    Nature medicine, 2004, Volume: 10, Issue:2

    Topics: Animals; Asthma; Bronchi; Bronchial Provocation Tests; Cytoplasmic Granules; Disease Models, Animal;

2004
Exacerbated Th2-mediated airway inflammation and hyperresponsiveness in autoimmune diabetes-prone NOD mice: a critical role for CD1d-dependent NKT cells.
    European journal of immunology, 2004, Volume: 34, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antigens, CD1; Antigens, CD1d; Asthma; Bronchial Hyperreactivity; B

2004
Inhaled dexamethasone differentially attenuates disease relapse and established allergic asthma in mice.
    Clinical immunology (Orlando, Fla.), 2004, Volume: 110, Issue:1

    Topics: Administration, Inhalation; Animals; Anti-Allergic Agents; Asthma; Bronchoalveolar Lavage; Dexametha

2004
Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland.
    American journal of pharmacogenomics : genomics-related research in drug development and clinical practice, 2004, Volume: 4, Issue:1

    Topics: Asthma; Base Sequence; Case-Control Studies; Chronic Disease; DNA Primers; Humans; Iceland; Mucus; P

2004
Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model.
    Journal of immunology (Baltimore, Md. : 1950), 2004, Jun-01, Volume: 172, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid;

2004
Mucus hypersecretion: a common symptom, a common mechanism?
    The European respiratory journal, 2004, Volume: 23, Issue:6

    Topics: Asthma; Chloride Channels; Cystic Fibrosis; Humans; Inflammation; Interleukin-9; Mucus; Receptors, I

2004
STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation.
    International immunology, 2004, Volume: 16, Issue:10

    Topics: Administration, Intranasal; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid

2004
Biomedicine. Eosinophils in asthma: remodeling a tangled tale.
    Science (New York, N.Y.), 2004, Sep-17, Volume: 305, Issue:5691

    Topics: Animals; Asthma; Cytokines; DNA-Binding Proteins; Eosinophil Peroxidase; Eosinophils; Erythroid-Spec

2004
Defining a link with asthma in mice congenitally deficient in eosinophils.
    Science (New York, N.Y.), 2004, Sep-17, Volume: 305, Issue:5691

    Topics: Allergens; Animals; Asthma; Diphtheria Toxin; Eosinophil Peroxidase; Eosinophils; Gene Targeting; Le

2004
A critical role for eosinophils in allergic airways remodeling.
    Science (New York, N.Y.), 2004, Sep-17, Volume: 305, Issue:5691

    Topics: Animals; Asthma; Bronchi; Cell Division; Collagen; Eosinophils; Interleukins; Leukocyte Count; Lung;

2004
Selective blockade of NF-kappa B activity in airway immune cells inhibits the effector phase of experimental asthma.
    Journal of immunology (Baltimore, Md. : 1950), 2004, Nov-01, Volume: 173, Issue:9

    Topics: Allergens; Animals; Apoptosis; Asthma; Bronchial Hyperreactivity; Chemokine CCL11; Chemokines, CC; F

2004
Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice.
    American journal of respiratory and critical care medicine, 2005, Mar-15, Volume: 171, Issue:6

    Topics: Administration, Inhalation; Aerosols; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar La

2005
[Severe asthma complicated with large mucoid impaction: successful removal with balloon catheter].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2004, Volume: 42, Issue:10

    Topics: Adult; Airway Obstruction; Asthma; Bronchoscopy; Catheterization; Female; Humans; Kidney Transplanta

2004
Reduced expression of transforming growth factor beta 1 exacerbates pathology in an experimental asthma model.
    European journal of immunology, 2005, Volume: 35, Issue:1

    Topics: Animals; Asthma; Cytokines; Disease Models, Animal; Female; Heterozygote; Immunization; Immunoglobul

2005
Respiratory syncytial virus-induced exaggeration of allergic airway disease is dependent upon CCR1-associated immune responses.
    European journal of immunology, 2005, Volume: 35, Issue:1

    Topics: Allergens; Animals; Asthma; Cockroaches; Female; Humans; Immunity, Cellular; Interleukin-13; Lung; M

2005
Therapeutic dosing with anti-interleukin-13 monoclonal antibody inhibits asthma progression in mice.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Ch

2005
[Concentrations of carcinoembryonic antigen in serum and bronchoalveolar lavage fluid of asthmatic patients with mucoid impaction].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2004, Volume: 42, Issue:12

    Topics: Aged; Airway Obstruction; Asthma; Bronchial Diseases; Bronchiectasis; Bronchoalveolar Lavage Fluid;

2004
An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model.
    International immunopharmacology, 2005, Volume: 5, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Movement; Chromones; C

2005
[Effects of interleukin-13 on the gob-5 and MUC5AC expression in lungs of a murine asthmatic model].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2004, Volume: 27, Issue:12

    Topics: Animals; Asthma; Chloride Channels; Disease Models, Animal; Immunohistochemistry; Interleukin-13; Ma

2004
[The preventive effect of bacillus Calmette-Guerin vaccination in early life on airway inflammation and mucus production in a murine model of asthma].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2005, Volume: 28, Issue:1

    Topics: Animals; Asthma; BCG Vaccine; Bronchi; Disease Models, Animal; Lung; Mice; Mice, Inbred C57BL; Mucin

2005
Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2005, Volume: 35, Issue:3

    Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveol

2005
Atelectasis of the right medial basal segment mimicking primary lung cancer in an asthmatic patient.
    International journal of clinical practice. Supplement, 2005, Issue:147

    Topics: Asthma; Diagnosis, Differential; Female; Humans; Lung Neoplasms; Middle Aged; Mucus; Pulmonary Atele

2005
A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus hypersecretion.
    Chest, 2005, Volume: 127, Issue:6

    Topics: Analysis of Variance; Asthma; Biomarkers; Bronchoalveolar Lavage Fluid; Bronchoscopy; Case-Control S

2005
Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma.
    American journal of respiratory cell and molecular biology, 2005, Volume: 33, Issue:3

    Topics: Animals; Asthma; Cells, Cultured; Chloride Channels; Disease Models, Animal; Female; Gastrointestina

2005
Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model.
    The Journal of allergy and clinical immunology, 2005, Volume: 116, Issue:2

    Topics: Adrenergic beta-Agonists; Albuterol; Animals; Apoptosis; Asthma; Bronchial Hyperreactivity; Disease

2005
Characteristic features of allergic airway inflammation in a murine model of infantile asthma.
    International archives of allergy and immunology, 2005, Volume: 138, Issue:1

    Topics: Age Factors; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Di

2005
Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 290, Issue:1

    Topics: Animals; Antigen-Antibody Reactions; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid

2006
Time to death, airway wall inflammation and remodelling in fatal asthma.
    The European respiratory journal, 2005, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Albuterol; Asthma; Bronchodilator Agents; Death; Female; Humans; Lung; Male; Mucu

2005
IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production.
    Journal of immunology (Baltimore, Md. : 1950), 2005, Sep-15, Volume: 175, Issue:6

    Topics: Allergens; Animals; Asthma; Interleukin-13; Interleukin-4; Mice; Mice, Inbred BALB C; Mice, Transgen

2005
Effect of disodium cromoglycate on airway mucus secretion during antigen-induced late asthmatic responses in a murine model of asthma.
    International archives of allergy and immunology, 2005, Volume: 138, Issue:3

    Topics: Airway Obstruction; Animals; Anti-Asthmatic Agents; Antigens; Asthma; Bronchoalveolar Lavage Fluid;

2005
Chronic mucus hypersecretion: a marker of asthma in young adults?
    Respiratory medicine, 2005, Volume: 99, Issue:12

    Topics: Adult; Asthma; Bronchial Provocation Tests; Chi-Square Distribution; Chronic Disease; Cross-Sectiona

2005
Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo.
    The Journal of allergy and clinical immunology, 2005, Volume: 116, Issue:6

    Topics: Animals; Asthma; Body Temperature; Body Weight; Bronchial Hyperreactivity; Chloride Channels; Cytoki

2005
Anti-T-cell Ig and mucin domain-containing protein 1 antibody decreases TH2 airway inflammation in a mouse model of asthma.
    The Journal of allergy and clinical immunology, 2005, Volume: 116, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Asthma; Cytokines; Disease Models, Animal; Female; Hepatitis A Viru

2005
Erratum: name change.
    American journal of respiratory cell and molecular biology, 2006, Volume: 34, Issue:3

    Topics: Animals; Asthma; Chloride Channels; Disease Models, Animal; Mice; Mucoproteins; Mucus; Respiratory M

2006
Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:3

    Topics: Adenine; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar La

2006
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma.
    The Journal of clinical investigation, 2006, Volume: 116, Issue:3

    Topics: Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Dendritic Cells; Disease Models, Ani

2006
Niflumic acid suppresses interleukin-13-induced asthma phenotypes.
    American journal of respiratory and critical care medicine, 2006, Jun-01, Volume: 173, Issue:11

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Chloride Channels; Eosinophils; Goblet Cells; Hyperpl

2006
Chronic cough. It can be helped.
    Mayo Clinic health letter (English ed.), 2006, Volume: 24, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Asthma; Chronic Disease; Cough; Gastroesophageal Reflux; H

2006
Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness.
    International immunology, 2006, Volume: 18, Issue:6

    Topics: Animals; Asthma; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Embryo, Mammalian; Eosinop

2006
Effects of ultrafine carbon particle inhalation on allergic inflammation of the lung.
    The Journal of allergy and clinical immunology, 2006, Volume: 117, Issue:4

    Topics: Administration, Inhalation; Air Pollutants; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid

2006
Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma.
    International immunopharmacology, 2006, Volume: 6, Issue:6

    Topics: Acetates; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disea

2006
The effects of low dose leukotriene receptor antagonist therapy on airway remodeling and cysteinyl leukotriene expression in a mouse asthma model.
    Experimental & molecular medicine, 2006, Apr-30, Volume: 38, Issue:2

    Topics: Acetates; Airway Obstruction; Animals; Anti-Asthmatic Agents; Asthma; Collagen; Cyclopropanes; Cyste

2006
Death receptor-6 regulates the development of pulmonary eosinophilia and airway inflammation in a mouse model of asthma.
    Immunology letters, 2006, Jul-15, Volume: 106, Issue:1

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Interferon-gamma; Mic

2006
Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Jul-18, Volume: 103, Issue:29

    Topics: Alcohol Dehydrogenase; Animals; Asthma; Dendritic Cells; Exocrine Glands; Glutathione Reductase; Inf

2006
Follistatin is a candidate endogenous negative regulator of activin A in experimental allergic asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2006, Volume: 36, Issue:7

    Topics: Activins; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Follistatin

2006
ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice.
    Molecular and cellular biology, 2006, Volume: 26, Issue:18

    Topics: ADAM Proteins; Allergens; Animals; Asthma; Breeding; Bronchial Hyperreactivity; Female; Gene Targeti

2006
Secretory phospholipases A2 stimulate mucus secretion, induce airway inflammation, and produce secretory hyperresponsiveness to neutrophil elastase in ferret trachea.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:1

    Topics: Animals; Asthma; Ferrets; Glycoconjugates; Group II Phospholipases A2; Humans; In Vitro Techniques;

2007
CCR3 monoclonal antibody inhibits airway eosinophilic inflammation and mucus overproduction in a mouse model of asthma.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:12

    Topics: Animals; Antibodies, Monoclonal; Asthma; Bronchoalveolar Lavage Fluid; Eosinophilia; Eosinophils; Er

2006
Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling.
    The American journal of pathology, 2006, Volume: 169, Issue:6

    Topics: Animals; Asthma; Chemokine CCL11; Chemokines, CC; Collagen; Eosinophils; Inflammation; Interleukin-1

2006
[Effects of glucocorticoid on airway mucus secretion in asthma: experiment with asthmatic mouse model].
    Zhonghua yi xue za zhi, 2006, Sep-19, Volume: 86, Issue:35

    Topics: Aluminum Hydroxide; Animals; Asthma; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, An

2006
Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2006, Volume: 36, Issue:12

    Topics: Animals; Arginase; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cells

2006
IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Mar-01, Volume: 178, Issue:5

    Topics: Animals; Asthma; Chemokine CCL11; Chemokines, CC; Epithelial Cells; Hematopoietic Stem Cell Transpla

2007
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation.
    European journal of immunology, 2007, Volume: 37, Issue:4

    Topics: Allergens; Animals; Asthma; Cell Differentiation; Immune Sera; Intramolecular Oxidoreductases; Macro

2007
Inhaled CD86 antisense oligonucleotide suppresses pulmonary inflammation and airway hyper-responsiveness in allergic mice.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3

    Topics: Animals; Asthma; B7-1 Antigen; B7-2 Antigen; Bronchoalveolar Lavage Fluid; Cell Line; Chemokine CCL1

2007
Coexposure to environmental tobacco smoke increases levels of allergen-induced airway remodeling in mice.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Apr-15, Volume: 178, Issue:8

    Topics: Actins; Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Chemokine CCL11; Chemokines,

2007
The tick salivary protein, Salp15, inhibits the development of experimental asthma.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Jun-01, Volume: 178, Issue:11

    Topics: Adjuvants, Immunologic; Animals; Asthma; Bronchial Hyperreactivity; CD4-Positive T-Lymphocytes; Dise

2007
Plasminogen is an important regulator in the pathogenesis of a murine model of asthma.
    American journal of respiratory and critical care medicine, 2007, Aug-15, Volume: 176, Issue:4

    Topics: Animals; Antifibrinolytic Agents; Asthma; Bronchoalveolar Lavage Fluid; Collagen; Disease Models, An

2007
Glycogen synthase kinase-3beta inhibition attenuates asthma in mice.
    American journal of respiratory and critical care medicine, 2007, Sep-01, Volume: 176, Issue:5

    Topics: Analysis of Variance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Enzyme Inhibitors; E

2007
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
    Nature medicine, 2007, Volume: 13, Issue:7

    Topics: Animals; Asthma; Cells, Cultured; Female; gamma-Aminobutyric Acid; Humans; Mice; Mice, Inbred BALB C

2007
A new link to airway obstruction in asthma.
    Nature medicine, 2007, Volume: 13, Issue:7

    Topics: Airway Obstruction; Asthma; gamma-Aminobutyric Acid; Humans; Mucus; Respiratory System; Signal Trans

2007
Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT-6 peptide.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Aug-15, Volume: 179, Issue:4

    Topics: Acute Disease; Administration, Intranasal; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Mo

2007
Increased expression of human calcium-activated chloride channel 1 gene is correlated with mucus overproduction in Chinese asthmatic airway.
    Cell biology international, 2007, Volume: 31, Issue:11

    Topics: Aged; Asthma; Calcium; China; Chloride Channels; Female; Gene Expression; Humans; Male; Middle Aged;

2007
Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2007, Volume: 37, Issue:9

    Topics: Aging; Animals; Asthma; B-Lymphocytes; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Enzy

2007
Anti-inflammatory and anti-allergic effects of kefir in a mouse asthma model.
    Immunobiology, 2007, Volume: 212, Issue:8

    Topics: Administration, Oral; Animals; Asthma; Bronchial Hyperreactivity; Cultured Milk Products; Cytokines;

2007
Inhaled mannitol changes the sputum properties in asthmatics with mucus hypersecretion.
    Respirology (Carlton, Vic.), 2007, Volume: 12, Issue:5

    Topics: Aged; Asthma; Bronchodilator Agents; Diuretics, Osmotic; Elasticity; Ethanolamines; Female; Formoter

2007
The involvement of type 1a angiotensin II receptors in the regulation of airway inflammation in a murine model of allergic asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2007, Volume: 37, Issue:11

    Topics: Animals; Asthma; Bronchitis; Bronchoalveolar Lavage Fluid; Cell Count; Cell Differentiation; Cytokin

2007
IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:10

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Fibrosis; Granuloma; Interleukin-10; Interle

2007
Glutamine preferentially inhibits T-helper type 2 cell-mediated airway inflammation and late airway hyperresponsiveness through the inhibition of cytosolic phospholipase A(2) activity in a murine asthma model.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2008, Volume: 38, Issue:2

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Cytokines; Disease Models, Animal; Eosinophi

2008
Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease.
    Journal of immunology (Baltimore, Md. : 1950), 2008, May-01, Volume: 180, Issue:9

    Topics: Aged; Animals; Asthma; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Epithelial Cells; Fe

2008
Mucous obstruction and airway hyperresponsiveness in mice.
    American journal of respiratory and critical care medicine, 2008, May-15, Volume: 177, Issue:10

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Disease Models, Animal; Mic

2008
Fatal bronchial asthma in children: report of three cases.
    Southern medical journal, 1967, Volume: 60, Issue:5

    Topics: Asthma; Bronchi; Child, Preschool; Death; Female; Humans; Male; Mucus; Pulmonary Emphysema; Pulmonar

1967
The pharmacologic basis of asthma therapy.
    Comprehensive therapy, 1980, Volume: 6, Issue:4

    Topics: Adrenal Cortex Hormones; Adrenergic alpha-Antagonists; Asthma; Bronchi; Cromolyn Sodium; Humans; Mas

1980
Pulmonary mucociliary clearance.
    Lancet (London, England), 1982, Jan-23, Volume: 1, Issue:8265

    Topics: Asthma; Cilia; Cystic Fibrosis; Humans; Kartagener Syndrome; Lung; Mucus; Respiratory Tract Diseases

1982
An early Southern description of Curschmann's spirals.
    Clinical notes on respiratory diseases, 1982,Summer, Volume: 21, Issue:1

    Topics: Asthma; History, 19th Century; Humans; Ipecac; Male; Mucus; Tennessee

1982
Long-term ipratropium bromide nebuliser therapy and lung mucociliary clearance.
    Lancet (London, England), 1982, Aug-07, Volume: 2, Issue:8293

    Topics: Asthma; Atropine Derivatives; Bronchitis; Cilia; Humans; Ipratropium; Lung; Mucus; Respiratory Thera

1982
[The role of bronchial hyperresponsiveness in airway mucus secretion].
    Nihon Kyobu Shikkan Gakkai zasshi, 1983, Volume: 21, Issue:10

    Topics: Adult; Animals; Asthma; Dogs; Exocrine Glands; Female; Histamine H1 Antagonists; Humans; In Vitro Te

1983
Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma.
    Lancet (London, England), 1982, Jul-03, Volume: 2, Issue:8288

    Topics: Adult; Aged; Asthma; Blood Proteins; Bronchi; Child; Eosinophil Granule Proteins; Eosinophils; Femal

1982
Effect of inhaled ipratropium bromide on tracheal mucociliary transport in bronchial asthma.
    The Mount Sinai journal of medicine, New York, 1984, Volume: 51, Issue:2

    Topics: Asthma; Atropine Derivatives; Cilia; Humans; Ipratropium; Mucus

1984
Mast cells and asthma. The role of mast cell mediators in the pathogenesis of allergic asthma.
    Annals of allergy, 1983, Volume: 51, Issue:1 Pt 1

    Topics: Airway Obstruction; Asthma; Bradykinin; Capillary Permeability; Histamine; Humans; Leukotriene E4; M

1983
Possible mechanisms underlying mucus secretion in aspirin-sensitive asthma.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 1983, Volume: 20 Suppl 1

    Topics: Aspirin; Asthma; Bronchi; Humans; Lipoxygenase; Models, Biological; Mucus; Prostaglandins

1983
Diurnal variation in asthma.
    Archives of disease in childhood, 1984, Volume: 59, Issue:9

    Topics: Airway Resistance; Asthma; Bronchodilator Agents; Circadian Rhythm; Epinephrine; Gastroesophageal Re

1984
Treatment of bronchial asthma.
    Agents and actions. Supplements, 1984, Volume: 14

    Topics: Anti-Inflammatory Agents; Asthma; Cilia; Humans; Immunosuppressive Agents; Mucus; Respiratory Hypers

1984
Acute respiratory failure in a young asthmatic patient.
    Chest, 1983, Volume: 84, Issue:6

    Topics: Acute Disease; Adult; Asthma; Bronchography; Female; Humans; Mucus; Pneumothorax; Respiratory Distre

1983
A model for assessing bronchial mucus transport.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1984, Volume: 25, Issue:2

    Topics: Adolescent; Adult; Aerosols; Aged; Asthma; Biological Transport; Bronchi; Female; Humans; Krypton; M

1984
Allergic mucociliary dysfunction.
    The Laryngoscope, 1983, Volume: 93, Issue:1

    Topics: Antigens; Asthma; Cilia; Humans; Mucous Membrane; Mucus; Rhinitis, Allergic, Seasonal; SRS-A; Trache

1983
Status Asthmaticus: use of acetylcysteine during bronchoscopy and lavage to remove mucous plugs.
    Annals of allergy, 1983, Volume: 50, Issue:2

    Topics: Acetylcysteine; Adult; Asthma; Bronchoscopy; Child; Female; Humans; Male; Middle Aged; Mucus; Therap

1983
Control and modulation of airway epithelial cells and their secretions.
    Experimental lung research, 1983, Volume: 4, Issue:2

    Topics: Animals; Asthma; Bronchitis; Chronic Disease; Cystic Fibrosis; Disease Models, Animal; Dogs; Epithel

1983
The structure of bronchial plugs in mucoid impaction, bronchocentric granulomatosis and asthma.
    Histopathology, 1983, Volume: 7, Issue:2

    Topics: Adult; Aged; Aspergillosis, Allergic Bronchopulmonary; Asthma; Bronchi; Bronchoscopy; Eosinophils; F

1983
Calcium blockers and bronchoconstriction.
    The American review of respiratory disease, 1983, Volume: 127, Issue:6

    Topics: Animals; Asthma; Bronchi; Bronchial Spasm; Calcium Channel Blockers; Humans; Mucus; Muscle, Smooth;

1983
Impaired tracheobronchial clearance in patients with mild stable asthma.
    Thorax, 1983, Volume: 38, Issue:6

    Topics: Adult; Aerosols; Asthma; Bronchi; Cilia; Female; Humans; Lung; Male; Mucus; Polystyrenes; Respirator

1983
[Expectorant and liquescent preparations in the therapy of bronchial asthma and nonspecific lung diseases and their prevention].
    Klinicheskaia meditsina, 1980, Volume: 58, Issue:4

    Topics: Asthma; Drug Evaluation; Drug Therapy, Combination; Expectorants; Humans; Lung Diseases; Mucus; Pept

1980
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1982. A 51-year-old woman with chronic asthma and hemoptysis.
    The New England journal of medicine, 1982, Jun-17, Volume: 306, Issue:24

    Topics: Aspergillosis, Allergic Bronchopulmonary; Asthma; Bronchi; Bronchial Diseases; Bronchiectasis; Diagn

1982
Recurrent mucoid impaction in an asthmatic infant with cow's milk protein allergy.
    Annals of allergy, 1982, Volume: 48, Issue:5

    Topics: Animals; Asthma; Bronchoscopy; Cattle; Humans; Immunoglobulin E; Infant; Male; Milk Proteins; Mucus;

1982
The pathophysiology of asthma.
    Chest, 1982, Volume: 82, Issue:1 Suppl

    Topics: Animals; Asthma; Bronchial Spasm; Bronchitis; Edema; Guinea Pigs; Humans; Lung; Mast Cells; Mucous M

1982
Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro.
    The American review of respiratory disease, 1982, Volume: 126, Issue:3

    Topics: Asthma; Culture Techniques; Dose-Response Relationship, Drug; Humans; Lung; Mucus; Respiratory Hyper

1982
Lung mucociliary function in man: interdependence of bronchial and tracheal mucus transport velocities with lung clearance in bronchial asthma and healthy subjects.
    The Annals of occupational hygiene, 1982, Volume: 26, Issue:1-4

    Topics: Adult; Aerosols; Asthma; Cilia; Female; Humans; Male; Middle Aged; Mucus; Respiratory System

1982
Tracheobronchial mucus: abnormalities related to asthma and its treatment.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 1981, Volume: 18, Issue:1

    Topics: Airway Obstruction; Animals; Asthma; Biological Transport; Bronchi; Cilia; Constriction, Pathologic;

1981
[Accumulation of eosinophils in the nasal secretion in patients with bronchial asthma].
    Schweizerische medizinische Wochenschrift, 1981, Feb-14, Volume: 111, Issue:7

    Topics: Asthma; Bronchi; Eosinophils; Humans; Mucus; Nasal Mucosa

1981
Application of density gradient methods for the study of mucus glycoprotein and other macromolecular components of the sol and gel phases of asthmatic sputa.
    The Journal of biological chemistry, 1981, Jul-25, Volume: 256, Issue:14

    Topics: Amino Acids; Asthma; Carbohydrates; Centrifugation, Density Gradient; Gels; Glycoproteins; Humans; M

1981
[Eosinophil concentration in nasal secretion in bronchial asthma].
    Schweizerische medizinische Wochenschrift, 1981, Aug-15, Volume: 111, Issue:33

    Topics: Asthma; Diagnosis, Differential; Eosinophils; Humans; Leukocyte Count; Mucus; Nasal Mucosa; Rhinitis

1981
Mucous secretions.
    The Journal of allergy and clinical immunology, 1981, Volume: 68, Issue:5

    Topics: Asthma; Fluid Therapy; Humans; Mucus; Respiratory System

1981
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 49-1981. Hyperinflated right middle lobe in a 15-year-old asthmatic girl.
    The New England journal of medicine, 1981, Dec-03, Volume: 305, Issue:23

    Topics: Adolescent; Asthma; Bronchi; Bronchial Diseases; Diagnosis, Differential; Female; Humans; Lung; Mucu

1981
Alteration of tracheal mucociliary transport in airway disease. Effect of pharmacologic agents.
    Chest, 1981, Volume: 80, Issue:6 Suppl

    Topics: Animals; Asthma; Bronchitis; Bronchodilator Agents; Chromones; Cilia; Cystic Fibrosis; Dogs; Humans;

1981
Mucociliary dysfunction in bronchial asthma.
    Zeitschrift fur Erkrankungen der Atmungsorgane, 1981, Volume: 157, Issue:3

    Topics: Asthma; Cilia; Humans; Mucus

1981
[Modifiers of bronchial secretions in the asthmatic patient].
    Allergologia et immunopathologia, 1981, Volume: Suppl 9

    Topics: Asthma; Biological Transport; Bronchi; Cilia; Exocrine Glands; Expectorants; Humans; Mucous Membrane

1981
Exercise-induced asthma.
    British medical journal, 1980, Feb-23, Volume: 280, Issue:6213

    Topics: Asthma; Asthma, Exercise-Induced; Cold Temperature; Humans; Mucus

1980
Nocturnal asthma and circulating epinephrine, histamine, and cortisol.
    The New England journal of medicine, 1980, Nov-27, Volume: 303, Issue:22

    Topics: Asthma; Circadian Rhythm; Humans; Mucus

1980
Effect of dexamethasone on antigen-induced high molecular weight glycoconjugate secretion in allergic guinea pigs.
    American journal of respiratory cell and molecular biology, 1995, Volume: 13, Issue:2

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Eosinophils; G

1995
Socioeconomic status and indicators of asthma in children.
    American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:2

    Topics: Adolescent; Animals; Animals, Domestic; Asthma; Asthma, Exercise-Induced; Bronchial Hyperreactivity;

1995
The pathophysiological role of mucus production in inflammatory airway diseases.
    Respiratory medicine, 1995, Volume: 89, Issue:5

    Topics: Asthma; Bronchitis; Cystic Fibrosis; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; M

1995
Theoretic effects of mucus gland discharge on airway resistance in asthma.
    Chest, 1995, Volume: 107, Issue:3 Suppl

    Topics: Airway Resistance; Asthma; Bronchi; Humans; Mucus

1995
Identification of two major populations of mucins in respiratory secretions.
    American journal of respiratory and critical care medicine, 1994, Volume: 150, Issue:3

    Topics: Amino Acids; Asthma; Bronchitis; Chronic Disease; Humans; Methods; Microscopy, Electron; Molecular W

1994
[Case of bronchial asthma with bronchorrhea].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1993, May-10, Volume: 82, Issue:5

    Topics: Aged; Asthma; Bronchi; Humans; Male; Mucus

1993
Mucus hypersecretion and eosinophils in bronchoalveolar lavage fluid in adult patients with bronchial asthma.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 1993, Volume: 30, Issue:4

    Topics: Adult; Age Factors; Aged; Asthma; Bronchoalveolar Lavage Fluid; Eosinophils; Female; Humans; Immunog

1993
[Clinical features of bronchial asthma with mucus hypersecretion].
    Nihon Kyobu Shikkan Gakkai zasshi, 1993, Volume: 31, Issue:5

    Topics: Adult; Aged; Asthma; Bronchoalveolar Lavage Fluid; Female; Humans; Male; Middle Aged; Mucus; Respira

1993
Atopy, bronchial responsiveness, and symptoms in wheezy 3 year olds.
    Archives of disease in childhood, 1993, Volume: 68, Issue:3

    Topics: Asthma; Bronchitis; Child, Preschool; Humans; Mucus; Parasympatholytics; Respiratory Sounds

1993
Markers of mucus secretion and DNA levels in induced sputum from asthmatic and from healthy subjects.
    The American review of respiratory disease, 1993, Volume: 147, Issue:5

    Topics: Adult; Aged; Asthma; DNA; Female; Glycoproteins; Humans; Lactoferrin; Male; Middle Aged; Mucins; Muc

1993
Abnormalities of the airways and lung parenchyma in asthmatics: CT observations in 50 patients and inter- and intraobserver variability.
    European radiology, 1996, Volume: 6, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Asthma; Bronchi; Bronchiectasis; Bronchography; Female; Forced Expir

1996
Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma like symptoms in mice.
    Free radical biology & medicine, 1996, Volume: 21, Issue:2

    Topics: Animals; Asthma; Bronchi; Bronchoconstriction; Eosinophils; Free Radical Scavengers; Lung; Male; Mic

1996
Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma.
    The European respiratory journal, 1996, Volume: 9, Issue:7

    Topics: Age Factors; Asthma; Bronchi; Bronchitis; Case-Control Studies; Eosinophils; Epithelium; Exocrine Gl

1996
The importance of leukotrienes in airway inflammation in a mouse model of asthma.
    The Journal of experimental medicine, 1996, Oct-01, Volume: 184, Issue:4

    Topics: 5-Lipoxygenase-Activating Proteins; Allergens; Animals; Asthma; Bronchial Provocation Tests; Broncho

1996
Histamine H2 receptor-mediated airway goblet cell secretion and its modulation by histamine-degrading enzymes.
    The Journal of allergy and clinical immunology, 1997, Volume: 99, Issue:2

    Topics: Amine Oxidase (Copper-Containing); Animals; Asthma; Cimetidine; Dimaprit; Dose-Response Relationship

1997
[A patient with bronchial asthma and mucoid impaction who presented with a high concentration of carcinoembryonic antigen in serum].
    Nihon Kyobu Shikkan Gakkai zasshi, 1997, Volume: 35, Issue:8

    Topics: Adult; Asthma; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Carcinoembryonic Antigen; Femal

1997
Goblet cell degranulation after antigen challenge in sensitized guinea pigs. Role of neutrophils.
    American journal of respiratory and critical care medicine, 1998, Volume: 158, Issue:4

    Topics: 3,3'-Diaminobenzidine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Antigens; Asthm

1998
Diagnostic value of nasal provocation challenge with allergens in children.
    Allergy, 1998, Volume: 53, Issue:10

    Topics: Adolescent; Allergens; Antigens, Dermatophagoides; Asthma; Cell Count; Child; Child, Preschool; Conj

1998
[Effect of heparin on airway goblet cell secretion in sensitized guinea pigs].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 1998, Volume: 36, Issue:10

    Topics: Animals; Asthma; Depression, Chemical; Dose-Response Relationship, Drug; Goblet Cells; Guinea Pigs;

1998
Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucous plug.
    The Biochemical journal, 1999, Mar-01, Volume: 338 ( Pt 2)

    Topics: Asthma; Chromatography, Ion Exchange; Electrophoresis, Agar Gel; Humans; Microscopy, Electron; Mucin

1999
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.
    The Journal of clinical investigation, 1999, Volume: 103, Issue:6

    Topics: Airway Resistance; Animals; Asthma; Bronchi; Bronchoconstrictor Agents; Chemokine CCL11; Chemokines,

1999
Mechanisms of hypersecretion in acute asthma, proposed cause of death, and novel therapy.
    Pediatric pulmonology. Supplement, 1999, Volume: 18

    Topics: Animals; Asthma; Cause of Death; Goblet Cells; Guinea Pigs; Humans; Leukocyte Elastase; Mucus; Neutr

1999
Secretory leukocyte protease inhibitor prevents allergen-induced pulmonary responses in animal models of asthma.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Aerosols; Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoconst

1999
Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.
    Journal of immunology (Baltimore, Md. : 1950), 1999, May-15, Volume: 162, Issue:10

    Topics: Administration, Inhalation; Animals; Asthma; Bronchi; Eosinophilia; Eosinophils; Interleukin-13 Rece

1999
Mucus impaction presenting as a lung mass in an AIDS patient with asthma.
    AIDS (London, England), 1999, Sep-10, Volume: 13, Issue:13

    Topics: Acquired Immunodeficiency Syndrome; Adult; Asthma; Diagnosis, Differential; Humans; Lung; Lung Neopl

1999
T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production.
    The Journal of experimental medicine, 1999, Nov-01, Volume: 190, Issue:9

    Topics: Animals; Asthma; Disease Models, Animal; Eosinophilia; Flow Cytometry; Hypersensitivity; Inflammatio

1999
Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.
    Immunity, 1999, Volume: 11, Issue:4

    Topics: Aerosols; Amino Acid Substitution; Animals; Asthma; Bronchoalveolar Lavage Fluid; DNA-Binding Protei

1999
Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Jan-15, Volume: 164, Issue:2

    Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar L

2000
Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Mar-15, Volume: 164, Issue:6

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Allergens; Animals; Anti-Inflammatory Agents, Non-St

2000
Prostaglandin D2 as a mediator of allergic asthma.
    Science (New York, N.Y.), 2000, Mar-17, Volume: 287, Issue:5460

    Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Crosses, Geneti

2000
Distribution and severity of bronchiectasis in allergic bronchopulmonary aspergillosis (ABPA).
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2000, Volume: 37, Issue:1

    Topics: Aspergillosis, Allergic Bronchopulmonary; Asthma; Bronchi; Bronchiectasis; Bronchography; Humans; Mu

2000
Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance.
    American journal of respiratory and critical care medicine, 2000, Volume: 161, Issue:4 Pt 1

    Topics: Adult; Aged; Asthma; Female; Humans; Inflammation Mediators; Interleukin-8; Intubation, Intratrachea

2000
Interleukin-9 upregulates mucus expression in the airways.
    American journal of respiratory cell and molecular biology, 2000, Volume: 22, Issue:6

    Topics: Animals; Asthma; Carcinoma, Squamous Cell; DNA Primers; Epithelial Cells; Gene Expression; Glycoprot

2000
Macrolides, asthma, inflammation, and infection.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2000, Volume: 84, Issue:6

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Asthma; Bronchiolitis; Bronchitis; Humans; Mucus; T

2000
Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 279, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid;

2000
Mucus plugging as a cause of acute lobar overdistension.
    Pediatric emergency care, 2001, Volume: 17, Issue:1

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchoscopy; Child, Preschool; Cough; Diagnosis, Differe

2001
The homeostatic rôle of bronchoconstriction.
    Respiration; international review of thoracic diseases, 2001, Volume: 68, Issue:2

    Topics: Asthma; Bronchoconstriction; Homeostasis; Humans; Mucociliary Clearance; Mucus; Respiratory Muscles;

2001
Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Apr-24, Volume: 98, Issue:9

    Topics: Animals; Asthma; Cell Line; Chloride Channels; Cloning, Molecular; Disease Models, Animal; Epitheliu

2001
Suppression of asthma-like responses in different mouse strains by oral tolerance.
    American journal of respiratory cell and molecular biology, 2001, Volume: 24, Issue:5

    Topics: Administration, Inhalation; Administration, Oral; Animals; Antibodies; Antigens; Asthma; Bronchial P

2001
Gob genes, mucus and asthma.
    Trends in immunology, 2001, Volume: 22, Issue:7

    Topics: Animals; Asthma; Chloride Channels; Goblet Cells; Humans; Mucoproteins; Mucus

2001
[Plastic bronchitis and mucoid impaction--uncommon disease syndromes with expectoration mucus plugs].
    Pneumonologia i alergologia polska, 2001, Volume: 69, Issue:1-2

    Topics: Adult; Aged; Aged, 80 and over; Airway Obstruction; Aspergillosis, Allergic Bronchopulmonary; Asthma

2001
Murine cytomegalovirus infection alters Th1/Th2 cytokine expression, decreases airway eosinophilia, and enhances mucus production in allergic airway disease.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Sep-01, Volume: 167, Issue:5

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Cytomegalovirus Infections; Disease Models

2001
Immunostimulatory DNA sequences inhibit respiratory syncytial viral load, airway inflammation, and mucus secretion.
    The Journal of allergy and clinical immunology, 2001, Volume: 108, Issue:5

    Topics: Adjuvants, Immunologic; Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Bronchoconstrictor A

2001
Exposure to diesel exhaust exacerbates allergen-induced airway responses in guinea pigs.
    American journal of respiratory and critical care medicine, 2001, Nov-15, Volume: 164, Issue:10 Pt 1

    Topics: Allergens; Analysis of Variance; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavag

2001
Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B.
    The Biochemical journal, 2002, Feb-01, Volume: 361, Issue:Pt 3

    Topics: Asthma; Blotting, Western; Cystic Fibrosis; Dose-Response Relationship, Drug; Electrophoresis, Agar

2002
Tryptase inhibition blocks airway inflammation in a mouse asthma model.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Feb-15, Volume: 168, Issue:4

    Topics: Animals; Asthma; Bridged Bicyclo Compounds, Heterocyclic; Bronchial Diseases; Bronchial Hyperreactiv

2002
A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.
    The Journal of allergy and clinical immunology, 2002, Volume: 109, Issue:2

    Topics: Adult; Asthma; Biopsy; Bronchi; Chloride Channels; Forced Expiratory Volume; Gene Expression Regulat

2002
Histopathology of fatal asthma: drowning in mucus.
    Pediatric pulmonology, 2001, Volume: Suppl 23

    Topics: Adolescent; Adult; Airway Obstruction; Asthma; Drowning; Female; Humans; Male; Middle Aged; Mucus

2001
Pulmonary inflammation monitored noninvasively by MRI in freely breathing rats.
    Biochemical and biophysical research communications, 2002, Mar-22, Volume: 292, Issue:1

    Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Budesonide; Eosi

2002
Gene therapy of mucus hypersecretion in experimental asthma.
    Chest, 2002, Volume: 121, Issue:3 Suppl

    Topics: Animals; Asthma; Genetic Therapy; Mice; Mucus; Munc18 Proteins; Nerve Tissue Proteins; Proteins; Tra

2002
Mycobacterial infection inhibits established allergic inflammatory responses via alteration of cytokine production and vascular cell adhesion molecule-1 expression.
    Immunology, 2002, Volume: 105, Issue:3

    Topics: Animals; Antigens; Asthma; Cytokines; Endothelium, Vascular; Female; Immune Tolerance; Immunoglobuli

2002
CD4(+) T cell-dependent airway mucus production occurs in response to IL-5 expression in lung.
    American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 282, Issue:5

    Topics: Allergens; Animals; Asthma; CD4-Positive T-Lymphocytes; Eosinophils; Gene Expression; Goblet Cells;

2002
Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway.
    American journal of respiratory and critical care medicine, 2002, Apr-15, Volume: 165, Issue:8

    Topics: Asthma; Bronchi; Calcium; Cell Line; Chloride Channels; Gene Expression Regulation; Goblet Cells; Hu

2002
Does mucus hypersecretion matter in airway disease?
    Lancet (London, England), 2002, Jun-01, Volume: 359, Issue:9321

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Female; Humans; Male; Mice; Mucus; Niflumi

2002
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.
    Nature medicine, 2002, Volume: 8, Issue:8

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Epithelial Cells; Humans; In Situ Hybridization; Interle

2002
[Effect of beta-adrenergic drugs on bronchial secretion].
    Minerva medica, 1976, Mar-31, Volume: 67, Issue:16

    Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchi; Bronchitis; Drug Evaluation; Female; Hu

1976
Mucus antibodies in pulmonary tuberculosis and chronic obstructive lung disease.
    Lancet (London, England), 1976, Oct-16, Volume: 2, Issue:7990

    Topics: Animals; Antigen-Antibody Reactions; Asthma; Autoantibodies; Bronchitis; Fluorescent Antibody Techni

1976
Mucopolysaccharides in bronchial secretion of children.
    Zeitschrift fur mikroskopisch-anatomische Forschung, 1978, Volume: 92, Issue:2

    Topics: Asthma; Bronchi; Bronchitis; Child; Cystic Fibrosis; Glycosaminoglycans; Humans; Infant; Mucus

1978
The parasympathetic nervous system in airways disease.
    Scandinavian journal of respiratory diseases. Supplementum, 1979, Volume: 103

    Topics: Animals; Asthma; Bronchial Spasm; Disease Models, Animal; Dogs; Humans; Lung; Mucus; Parasympathetic

1979
Mucociliary clearance in anti-asthmatic drug evaluation.
    Scandinavian journal of respiratory diseases. Supplementum, 1979, Volume: 103

    Topics: Asthma; Bronchi; Bronchodilator Agents; Cilia; Drug Evaluation; Humans; Mucous Membrane; Mucus; Trac

1979
[Bronchial immunoglobulins in chronic and obstructive bronchopathies. Study by immunofluorescence].
    La Nouvelle presse medicale, 1979, Jun-07, Volume: 8, Issue:25

    Topics: Asthma; Bronchi; Bronchitis; Chronic Disease; Complement System Proteins; Fluorescent Antibody Techn

1979
[Tracheobronchial endoscopy in children].
    Acta oto-rhino-laryngologica Belgica, 1979, Volume: 33, Issue:1

    Topics: Age Factors; Anesthesia; Asthma; Bronchi; Bronchial Diseases; Bronchial Fistula; Bronchial Neoplasms

1979
Chemical markers of mucous and serum glycoproteins and their relation to viscosity in mucoid and purulent sputum from various hypersecretory diseases.
    The American review of respiratory disease, 1978, Volume: 117, Issue:3

    Topics: Asthma; Bronchial Diseases; Bronchiectasis; Bronchitis; Chronic Disease; Cystic Fibrosis; Female; Fu

1978
Histamine in nasal secretions.
    International archives of allergy and applied immunology, 1978, Volume: 57, Issue:3

    Topics: Adolescent; Adult; Asthma; Female; Histamine; Humans; Male; Mucus; Nasal Mucosa; Rhinitis, Allergic,

1978
Technique of coughing.
    JAMA, 1978, Jul-14, Volume: 240, Issue:2

    Topics: Asthma; Breathing Exercises; Bronchitis; Cough; Humans; Mucus; Respiration

1978
Ultrastructure of airways in children with asthma.
    Histopathology, 1978, Volume: 2, Issue:6

    Topics: Asthma; Basement Membrane; Bronchi; Child; Epithelium; Female; Humans; Lung; Male; Mucous Membrane;

1978
[Mucus transport in asthma].
    Bulletin of the International Union against Tuberculosis, 1976, Volume: 51, Issue:1 Pt 2

    Topics: Acetylcholine; Animals; Antigens; Ascaris; Asthma; Biological Transport; Dogs; Histamine; Lung Compl

1976
[Use of the method of express-diagnosis in acute and lingering courses of respiratory-syncytial viral infections in children].
    Voprosy okhrany materinstva i detstva, 1975, Volume: 20, Issue:5

    Topics: Acute Disease; Adolescent; Antigens, Viral; Asthma; Bronchitis; Bronchoscopy; Child; Child, Preschoo

1975
A study of western red cedar-induced asthma.
    Annals of allergy, 1975, Volume: 34, Issue:5

    Topics: Acetylcholine; Aerosols; Allergens; Anaphylaxis; Animals; Asthma; Drug Hypersensitivity; Eosinophils

1975
Tracheal mucous transport in experimental canine asthma.
    Journal of applied physiology, 1975, Volume: 39, Issue:6

    Topics: Animals; Antigens; Ascaris; Asthma; Cilia; Dogs; Lung Compliance; Mucus; Trachea

1975
[Examination of the bronchial secretion for eosinophiles (author's transl)].
    Praxis der Pneumologie, 1975, Volume: 29, Issue:5

    Topics: Asthma; Bronchi; Bronchial Diseases; Bronchial Spasm; Diagnosis, Differential; Eosinophils; Humans;

1975
Otitis media and chronic middle ear effusion in the asthmatic pediatric patient.
    Ear, nose, & throat journal, 1992, Volume: 71, Issue:9

    Topics: Adolescent; Asthma; Child; Child, Preschool; Chronic Disease; Ear, Middle; Humans; Infant; Middle Ea

1992
In vivo detection of a novel macrophage-derived protein involved in the regulation of mucus-like glycoconjugate secretion.
    The American review of respiratory disease, 1992, Volume: 146, Issue:6

    Topics: Adult; Animals; Antibodies, Monoclonal; Asthma; Bronchitis; Bronchoalveolar Lavage Fluid; Cells, Cul

1992
[Airway hyperresponsiveness and mucus secretion].
    Nihon Kyobu Shikkan Gakkai zasshi, 1990, Volume: 28, Issue:10

    Topics: Asthma; Autonomic Nervous System; Bronchi; Exocrine Glands; Humans; Mucus; Platelet Activating Facto

1990
Safety and possible efficacy of fiberoptic bronchoscopy with lavage in the management of refractory asthma with mucous impaction.
    Annals of allergy, 1991, Volume: 67, Issue:3

    Topics: Adult; Aged; Asthma; Bronchoscopy; Dyspnea; Female; Fiber Optic Technology; Humans; Hypoxia; Male; M

1991
Asthma, hay fever, and phlegm production associated with distinct patterns of allergy skin test reactivity, eosinophilia, and serum IgE levels. The Normative Aging Study.
    The American review of respiratory disease, 1991, Volume: 144, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; Asthma; Eosinophilia; Humans; Hypersensitivity; Immunoglobuli

1991
Effect of milk ingestion on pulmonary function in healthy and asthmatic subjects.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 1991, Volume: 28, Issue:5

    Topics: Adult; Airway Resistance; Analysis of Variance; Animals; Asthma; Female; Humans; Male; Middle Aged;

1991
Nearly fatal partial obstruction of the upper airway.
    Postgraduate medicine, 1990, Feb-01, Volume: 87, Issue:2

    Topics: Adult; Airway Obstruction; Asthma; Bronchi; Female; Histamine H1 Antagonists; Humans; Mucus; Nonpres

1990
Eosinophil cationic protein stimulates and major basic protein inhibits airway mucus secretion.
    The Journal of allergy and clinical immunology, 1991, Volume: 87, Issue:3

    Topics: Airway Obstruction; Animals; Asthma; Blood Proteins; Cats; Dose-Response Relationship, Drug; Enzyme-

1991
Changes in mucociliary clearance during acute exacerbations of asthma.
    The American review of respiratory disease, 1991, Volume: 143, Issue:5 Pt 1

    Topics: Acute Disease; Adult; Aerosols; Asthma; Female; Humans; Lung; Male; Mucociliary Clearance; Mucus; Ra

1991
Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy.
    The American review of respiratory disease, 1990, Volume: 141, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchial Provocation Tests; Child; Chronic Dise

1990
Mucoid impaction of upper lobe bronchi in the absence of proximal bronchiectasis.
    Chest, 1990, Volume: 98, Issue:4

    Topics: Adult; Asthma; Bronchi; Bronchiectasis; Bronchography; Female; Humans; Lung; Mucus

1990
Characterization of airway mucus from a fatal case of status asthmaticus.
    Pediatric pulmonology, 1988, Volume: 5, Issue:3

    Topics: Adolescent; Airway Obstruction; Asthma; Centrifugation, Density Gradient; Chromatography, Thin Layer

1988
Regulation of airway secretions.
    Chest, 1985, Volume: 87, Issue:1 Suppl

    Topics: Airway Obstruction; Asthma; Biological Transport; Epithelium; Humans; Ion Channels; Mucus; Respirato

1985
Chemical properties of bronchorrhea sputum in bronchial asthma.
    Chest, 1988, Volume: 94, Issue:6

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Asthma; Bronchial Provocation Tests; Femal

1988
Physiologic implications of the autonomic aberrations in cystic fibrosis.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1986, Volume: 18, Issue:4

    Topics: Adult; Airway Obstruction; Airway Resistance; Asthma; Autonomic Nervous System; Bronchi; Bronchial P

1986
Asthma as a link between chest illness in childhood and chronic cough and phlegm in young adults.
    British medical journal (Clinical research ed.), 1988, Mar-26, Volume: 296, Issue:6626

    Topics: Asthma; Bronchitis; Child; Chronic Disease; Cough; Female; Follow-Up Studies; Humans; Male; Mucus; P

1988
[Immunologic study of mucus in patients with allergic rhinopathy and bronchial asthma].
    Anales otorrinolaringologicos ibero-americanos, 1988, Volume: 15, Issue:5

    Topics: Asthma; Humans; Immunoglobulins; Mucus; Nasal Mucosa; Rhinitis, Allergic, Seasonal

1988
Effects of the PAF-antagonist CV-3988 on PAF-induced changes in mucus secretion and in respiratory and circulatory variables in ferrets.
    Agents and actions. Supplements, 1987, Volume: 21

    Topics: Animals; Asthma; Blood Cells; Ferrets; Mucus; Phospholipid Ethers; Platelet Activating Factor; Thiaz

1987
[Pathophysiology of chronic bronchitis].
    Wiener medizinische Wochenschrift (1946), 1986, Dec-31, Volume: 136, Issue:23-24

    Topics: Airway Resistance; Asthma; Bronchitis; Chronic Disease; Humans; Lung Diseases, Obstructive; Mucus; M

1986
[Intrinsic asthma in children].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1987, May-19, Volume: 76, Issue:21

    Topics: Adolescent; Age Factors; Allergens; Asthma; Calcium; Child; Humans; Lung; Mucus; Muscle, Smooth; Res

1987
The presence or absence of bronchial mucus in fatal asthma.
    The Journal of allergy and clinical immunology, 1987, Volume: 80, Issue:3 Pt 2

    Topics: Airway Obstruction; Asthma; Bronchi; Humans; Mucus

1987
The pathogenesis of severe asthma: a consensus report from the Workshop on Pathogenesis.
    The Journal of allergy and clinical immunology, 1987, Volume: 80, Issue:3 Pt 2

    Topics: Acute Disease; Airway Obstruction; Asthma; Bronchial Spasm; Humans; Lung; Mast Cells; Mucus; Pulmona

1987
Pulmonary eosinophilia.
    Journal of the Royal College of Physicians of London, 1986, Volume: 20, Issue:2

    Topics: Aspergillosis, Allergic Bronchopulmonary; Asthma; Drug-Related Side Effects and Adverse Reactions; E

1986
Re: Clinical aspects of mucus and mucous plugging in asthma.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 1986, Volume: 23, Issue:4

    Topics: Asthma; Expectorants; Humans; Mucus

1986
Evidence favouring PAF rather than leukotrienes in the pathogenesis of asthma.
    Pharmacological research communications, 1986, Volume: 18 Suppl

    Topics: Asthma; Bronchi; Eosinophils; Humans; Inflammation; Mucus; Platelet Activating Factor; Respiratory S

1986
Plastic bronchitis: large, branching, mucoid bronchial casts in children.
    AJR. American journal of roentgenology, 1985, Volume: 144, Issue:2

    Topics: Asthma; Bronchi; Bronchiectasis; Bronchitis; Bronchoscopy; Child; Child, Preschool; Female; Humans;

1985
Tension ball valve mucus plug in asthma.
    The American journal of medicine, 1985, Volume: 79, Issue:1

    Topics: Adult; Asthma; Female; Humans; Mucus; Positive-Pressure Respiration; Pulmonary Atelectasis; Radiogra

1985
Excessive accumulation of mucus in children with asthma: a potential role for erythromycin? A case discussion.
    The Journal of allergy and clinical immunology, 1986, Volume: 77, Issue:2

    Topics: Airway Obstruction; Asthma; Child, Preschool; Erythromycin; Glucocorticoids; Humans; Male; Mucus; Re

1986
Radioaerosol assessment of mucociliary clearance: towards definition of a normal range.
    The British journal of radiology, 1986, Volume: 59, Issue:698

    Topics: Adult; Aerosols; Aged; Asthma; Biological Transport; Bronchi; Bronchitis; Chronic Disease; Cilia; Fe

1986
Tracheobronchial mucociliary clearance in asthma: impairment during remission.
    Thorax, 1985, Volume: 40, Issue:3

    Topics: Adult; Aerosols; Asthma; Bronchi; Female; Humans; Lung; Male; Mucus; Remission, Spontaneous; Respira

1985
Mucoid impaction of the bronchus.
    American family physician, 1985, Volume: 31, Issue:4

    Topics: Asthma; Bronchial Diseases; Bronchitis; Bronchography; Humans; Mucus

1985
Use of acetylcysteine in bronchial asthma--another look.
    Annals of allergy, 1985, Volume: 54, Issue:4

    Topics: Acetylcysteine; Asthma; Bronchoscopy; Humans; Lung; Mucus; Respiratory Therapy; Therapeutic Irrigati

1985
Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease.
    British journal of diseases of the chest, 1985, Volume: 79, Issue:1

    Topics: Adolescent; Adult; Asthma; Bronchiectasis; Cilia; Female; Humans; Male; Middle Aged; Mucus; Nose; Rh

1985
The problem of mucus plugging in children with asthma.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 1985, Volume: 22, Issue:3

    Topics: Asthma; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Lung; Lung Diseases, Obs

1985
[Tracheobronchial clearance in the hypersecreting asthmatic patient].
    Revue de pneumologie clinique, 1985, Volume: 41, Issue:2

    Topics: Adult; Aerosols; Asthma; Bronchi; Cilia; Cough; Female; Humans; Ion Exchange Resins; Male; Middle Ag

1985
Deaths in primary asthma with special reference to pathology.
    Acta allergologica, 1971, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Aged; Asthma; Autopsy; Basement Membrane; Bronchi; Child; Child, Preschool; Eosin

1971
Hypersensitivity to phenylglycine acid chloride.
    The Journal of allergy and clinical immunology, 1973, Volume: 52, Issue:2

    Topics: Acids; Allergens; Aminocaproates; Asthma; Chemical Industry; Chlorides; Dust; Environmental Exposure

1973
Some histological changes in chronic bronchitis and asthma.
    Thorax, 1968, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Aged; Asthma; Basement Membrane; Biopsy; Bronchi; Bronchitis; Bronchoscopy; Eosin

1968
Immunologic response of young patients with asthma and-or recurrent respiratory infections to aerosol influenza immunization.
    The Journal of asthma research, 1970, Volume: 7, Issue:4

    Topics: Adult; Aerosols; Antibodies; Antibody Formation; Asthma; Child; Chronic Disease; gamma-Globulins; He

1970
[Cytological and cytochemical examinations in bronchial asthma in children].
    Gruzlica i choroby pluc; tuberculosis et pneumonologia, 1970, Volume: 38, Issue:8

    Topics: Adolescent; Asthma; Bronchi; Bronchoscopy; Child; Cytodiagnosis; Female; Glycosaminoglycans; Humans;

1970
Use of ultrasonic aerosols with ventilatory assistors.
    The Journal of asthma research, 1968, Volume: 5, Issue:4

    Topics: Aerosols; Amphotericin B; Asthma; Bronchial Diseases; Bronchodilator Agents; Cystic Fibrosis; Eosino

1968
[Immunoglobulin E. Biochemical, immunological properties and clinical significance (author's transl)].
    Klinische Wochenschrift, 1974, Jan-01, Volume: 52, Issue:1

    Topics: Antibodies; Antibodies, Anti-Idiotypic; Asthma; Basophils; Binding Sites, Antibody; Chemical Phenome

1974
Mutually exclusive groups of bronchitics and non-bronchitics in males.
    British journal of preventive & social medicine, 1974, Volume: 28, Issue:3

    Topics: Adult; Age Factors; Asthma; Body Height; Bronchitis; Cough; Dyspnea; Heart Diseases; Humans; Male; M

1974
The effects of storage and of potassium iodide, urea, N-acetyl-cysteine and triton X-100 on the viscosity of bronchial mucus.
    British journal of diseases of the chest, 1974, Volume: 68, Issue:0

    Topics: Acetylcysteine; Asthma; Bronchi; Bronchitis; Centrifugation; Humans; Mucus; Polyethylene Glycols; Po

1974
Conference on the scientific basis of respiratory therapy. Aerosol therapy. Introduction.
    The American review of respiratory disease, 1974, Volume: 110, Issue:6 Pt 2

    Topics: Adrenal Cortex Hormones; Aerosols; Asthma; Bronchi; Bronchodilator Agents; Chronic Disease; Expector

1974
Studies on the variation in the viscosity of bronchial mucus and a technique for reducing such variation.
    Biorheology, 1974, Volume: 11, Issue:2

    Topics: Asthma; Bronchi; Bronchitis; Humans; Mucus; Pulmonary Emphysema; Rheology; Sputum; Viscosity

1974
The physical and chemical properties of bronchial secretion.
    British journal of diseases of the chest, 1974, Volume: 68

    Topics: Asthma; Bronchi; Bronchiectasis; Bronchitis; Glycoproteins; Molecular Conformation; Mucus; Rheology;

1974
Immunoglobulins in tracheo-bronchial secretion with special reference to IgE.
    Clinical and experimental immunology, 1974, Volume: 16, Issue:3

    Topics: Adult; Aged; Asthma; Bronchi; Bronchial Neoplasms; Child, Preschool; Female; Humans; Immunoglobulin

1974
Maxillary sinusitis and bronchial asthma: correlation of roentgenograms, cultures, and thermograms.
    The Journal of allergy and clinical immunology, 1974, Volume: 53, Issue:5

    Topics: Adult; Aerobiosis; Aged; Asthma; Bronchitis; Escherichia coli; Haemophilus influenzae; Humans; Maxil

1974
Effect of corticosteroid on hyperactive carotid body and carotid sinus in asthmatics.
    The Journal of asthma research, 1972, Volume: 9, Issue:4

    Topics: Adrenal Cortex Hormones; Adult; Asthma; Carotid Body; Carotid Sinus; Chemoreceptor Cells; Female; Hu

1972
Bronchography in childhood asthma.
    The American journal of roentgenology, radium therapy, and nuclear medicine, 1972, Volume: 116, Issue:3

    Topics: Adolescent; Anesthesia, General; Asthma; Bronchi; Bronchial Spasm; Bronchiectasis; Bronchitis; Bronc

1972
Rare complications of bronchial asthma.
    The Journal of asthma research, 1972, Volume: 10, Issue:2

    Topics: Adult; Aged; Airway Obstruction; Allergens; Asthma; Bronchial Neoplasms; Bronchiectasis; Bronchitis;

1972
Investigation into observer and seasonal variation of the prevalence of respiratory symptoms at Schiermonnikoog.
    International journal of epidemiology, 1972,Spring, Volume: 1, Issue:1

    Topics: Adolescent; Age Factors; Asthma; Body Height; Cough; Dyspnea; Female; Humans; Laryngismus; Male; Muc

1972
Vitamin A: occurrence and distribution in fractionated mucus.
    Lipids, 1973, Volume: 8, Issue:5

    Topics: Animals; Asthma; Bronchi; Bronchitis; Cattle; Centrifugation; Cervix Mucus; Chromatography, Thin Lay

1973
Mucoid inpaction of the bronchus. Diagnosis and treatment.
    The American review of respiratory disease, 1973, Volume: 108, Issue:4

    Topics: Acetylcysteine; Adult; Airway Obstruction; Asthma; Bronchial Diseases; Bronchitis; Female; Humans; I

1973
[Proteins of the bronchial mucus in intrinsic asthma].
    Revista clinica espanola, 1973, Jun-15, Volume: 130, Issue:1

    Topics: Asthma; Blood Proteins; Humans; Immunoglobulins; Mucus

1973
[Serum and secretory immunoglobulins during bronchopneumopathies in children].
    Le Poumon et le coeur, 1973, Volume: 29, Issue:4

    Topics: Adolescent; Adult; Asthma; Bronchitis; Child; Child, Preschool; Humans; Immunoglobulin A; Immunoglob

1973
Output characteristics and clinical efficacy of ultrasonic nebulizers.
    The Journal of asthma research, 1968, Volume: 5, Issue:4

    Topics: Acetylcysteine; Aerosols; Asthma; Bronchial Diseases; Child; Cortisone; Cystic Fibrosis; Humans; Muc

1968
Bronchospasm in asthma.
    The American review of respiratory disease, 1972, Volume: 106, Issue:5

    Topics: Airway Resistance; Asthma; Bronchial Spasm; Bronchodilator Agents; Female; Humans; Mucus; Pulmonary

1972
Muscle and mucous gland size in the major bronchi of patients with chronic bronchitis, asthma, and asthmatic bronchitis.
    The American review of respiratory disease, 1971, Volume: 104, Issue:3

    Topics: Adult; Asthma; Autopsy; Bronchi; Bronchitis; Cartilage; Chronic Disease; Connective Tissue; Exocrine

1971
Lipid composition of human bronchial mucus.
    Lipids, 1971, Volume: 6, Issue:11

    Topics: Asthma; Bronchi; Cholesterol; Chromatography, Thin Layer; Esters; Fatty Acids, Nonesterified; Glycer

1971
[Biochemical analysis of bronchial secretions in chronic obstructive lung disease (chronic bronchitis, asthma). I. Homogenizing of bronchial secretions with ultrasound and its importance for biochemical analysis].
    Pneumonologie. Pneumonology, 1971, Volume: 144, Issue:2

    Topics: Asthma; Bronchitis; Electrophoresis; Humans; Immunoelectrophoresis; Lung Diseases, Obstructive; Mucu

1971
[Biochemical analysis of bronchial secretions in chronic obstructive lung disease (chronic bronchitis and asthma). II. Classification of bronchial secretions on the basis of biochemical analyses].
    Pneumonologie. Pneumonology, 1971, Volume: 144, Issue:2

    Topics: Asthma; Bronchitis; Electrophoresis; Humans; Immunoelectrophoresis; Lung Diseases, Obstructive; Mucu

1971
The colon mucus antibody.
    Journal of clinical pathology, 1971, Volume: 24, Issue:9

    Topics: Antibodies; Asthma; Colitis, Ulcerative; Colon; Fluoresceins; Humans; Immune Sera; Immunoglobulin A;

1971
[Severe asthma. Study of 80 cases of severe and fatal asthma].
    Annales de medecine interne, 1969, Volume: 120, Issue:2

    Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti

1969
[Modifications of physico-chemical properties of expectoration in various pathological states and their treatment].
    Le Poumon et le coeur, 1970, Volume: 26, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Asthma; Bronchitis; Chronic Disease; Female; Haemophilus influenzae;

1970
Immunopathologic aspects of lung disease.
    Archives of internal medicine, 1970, Volume: 126, Issue:3

    Topics: Anaphylaxis; Animals; Anti-Glomerular Basement Membrane Disease; Antibodies, Anti-Idiotypic; Antibod

1970
Infection and chronic bronchitis. A study carried out in general practice.
    Respiration; international review of thoracic diseases, 1969, Volume: 26

    Topics: Adult; Aged; Antibodies; Asthma; Bronchitis; Chronic Disease; Family Practice; Female; Haemophilus I

1969
[Results of bronchologic studies in children with bronchial asthma syndrome].
    Monatsschrift fur Kinderheilkunde, 1969, Volume: 117, Issue:10

    Topics: Adolescent; Asthma; Biopsy; Bronchi; Bronchial Diseases; Bronchiectasis; Bronchitis; Bronchoscopy; C

1969
Deaths amongst asthmatics in Tasmania, 1964-1966.
    The Medical journal of Australia, 1970, May-30, Volume: 1, Issue:22

    Topics: Adolescent; Adult; Aerosols; Aged; Aminophylline; Asthma; Australia; Autopsy; Child; Child, Preschoo

1970
Chronic respiratory disease among nonsmokers in Hagerstown, Maryland. I. Design of the study and prevalence of symptoms.
    Environmental research, 1971, Volume: 4, Issue:2

    Topics: Adult; Age Factors; Asthma; Chronic Disease; Coronary Disease; Cough; Dyspnea; Humans; Hypertension;

1971
Clearance from alveoli to the ciliary escalator: implications for pulmonary diseases.
    Aspen Emphysema Conference, 1967, Volume: 10

    Topics: Animals; Anura; Asthma; Bronchiolitis, Viral; Bronchitis; Cilia; Foreign Bodies; Mucus; Phagocytosis

1967
Ultrasonic nebulization in the treatment of intractable bronchial asthma in children.
    The Journal of asthma research, 1968, Volume: 5, Issue:4

    Topics: Adolescent; Aerosols; Asthma; Bronchial Spasm; Child; Female; Humans; Isoproterenol; Isotonic Soluti

1968
Handling emotional problems associated with pediatric allergy.
    Annals of allergy, 1968, Volume: 26, Issue:7

    Topics: Asthma; Blood Volume; Capillaries; Child; Child, Preschool; Emotions; Guilt; Hostility; Humans; Hype

1968
A hypothesis for pulmonary clearance and its implications.
    The American review of respiratory disease, 1968, Volume: 98, Issue:3

    Topics: Animals; Anura; Asthma; Bronchi; Bronchitis; Cilia; Emphysema; Epithelial Cells; Lung; Mucus; Pulmon

1968
Expectorant activity of water in acute asthma attacks.
    American journal of diseases of children (1960), 1968, Volume: 116, Issue:4

    Topics: Animals; Asthma; Bronchi; Expectorants; Female; Male; Mucus; Rabbits; Water

1968
[Effect of mucolytic agents in the management ofbronchial asthma. Personal experience with 20 cases].
    Prensa medica argentina, 1968, May-31, Volume: 55, Issue:14

    Topics: Asthma; Expectorants; Humans; Mucus

1968
Bacterial flora of bronchial secretion.
    Acta medica Academiae Scientiarum Hungaricae, 1968, Volume: 25, Issue:2

    Topics: Adolescent; Anti-Bacterial Agents; Asthma; Bacteria; Bronchi; Bronchial Diseases; Bronchiectasis; Br

1968
Mucoid impaction of the bronchi in relation to asthma an plastic bronchitis.
    Thorax, 1968, Volume: 23, Issue:4

    Topics: Adult; Asthma; Bronchial Diseases; Bronchitis; Diagnosis, Differential; Female; Humans; Lung Neoplas

1968
The bronchographic appearances of early chronic bronchitis.
    The British journal of radiology, 1969, Volume: 42, Issue:494

    Topics: Asthma; Bronchiectasis; Bronchitis; Bronchography; Chronic Disease; Female; Humans; Male; Mucus; Smo

1969
Sudden death in a young asthmatic.
    British medical journal, 1969, Apr-05, Volume: 2, Issue:5648

    Topics: Adolescent; Asthma; Bronchi; Chromones; Death, Sudden; Humans; Male; Mucus; Prednisone

1969
[Significance and methods of obtaining bronchial secretion].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1969, Mar-01, Volume: 24, Issue:5

    Topics: Asthma; Bronchi; Bronchitis; Bronchoscopy; Humans; Intubation, Intratracheal; Mucus; Respiratory Tra

1969
Use of acetylcysteine in bronchial asthma and emphysema.
    The Journal of asthma research, 1969, Volume: 6, Issue:4

    Topics: Acetylcysteine; Adolescent; Adult; Aerosols; Aged; Asthma; Bronchitis; Child; Chronic Disease; Ethan

1969
[In-vitro studies with the secretolytic agent Bisolvon (supplement to preliminary clinico-experimental experiences)].
    Praxis, 1965, Nov-11, Volume: 54, Issue:45

    Topics: Asthma; Expectorants; Humans; In Vitro Techniques; Mucus; Sputum

1965
Plastic bronchitis, mucoid impaction of the bronchi and allergic broncho-pulmonary aspergillosis, and their relationship to bronchial asthma.
    Annals of allergy, 1966, Volume: 24, Issue:11

    Topics: Adolescent; Adult; Aged; Aspergillosis; Asthma; Bronchial Diseases; Bronchitis; Eosinophilia; Exudat

1966
Mucoid impaction of the bronchi.
    The Annals of thoracic surgery, 1966, Volume: 2, Issue:1

    Topics: Adolescent; Adult; Aged; Asthma; Bronchial Diseases; Child; Child, Preschool; Expectorants; Female;

1966
[Atelectasis caused by mucoid impaction in 2 asthmatic children].
    Minerva medica, 1966, Nov-28, Volume: 57, Issue:95

    Topics: Asthma; Child; Humans; Infant; Male; Mucus; Pulmonary Atelectasis

1966
Mucoid impaction of the bronchi.
    The American journal of roentgenology, radium therapy, and nuclear medicine, 1966, Volume: 96, Issue:4

    Topics: Adult; Asthma; Bronchial Diseases; Bronchitis; Bronchography; Female; Humans; Lung Abscess; Male; Mi

1966