guaiane has been researched along with Influenza--Human* in 1 studies
1 other study(ies) available for guaiane and Influenza--Human
Article | Year |
---|---|
Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities.
Five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βH-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αH-guai-10(15)-en-5β,8β-endoxide(4) and 7-hydroxy-5(10),6,8-cadinatriene-4-one(5), together with seven known analogs were isolated from the rhizomes of Curcuma wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D NMR techniques, and the structures of 1 and 2 were confirmed by single-crystal X-ray diffraction experiment. Compounds 1-10 and 12 showed significant in vitro antiviral activity against the influenza virus A with IC₅₀ values ranged from 6.80 to 39.97 μM, and SI values ranged from 6.35 to 37.25. Topics: Animals; Antiviral Agents; Cell Line; Curcuma; Dogs; Humans; Influenza, Human; Magnetic Resonance Spectroscopy; Molecular Structure; Polycyclic Sesquiterpenes; Sesquiterpenes; Sesquiterpenes, Guaiane | 2013 |