Page last updated: 2024-10-17

guaiacol and Goiter

guaiacol has been researched along with Goiter in 8 studies

Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)
methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.
guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.

Goiter: Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).

Research Excerpts

ExcerptRelevanceReference
"Thyroid peroxidase (TPO) iodide and guaiacol oxidation activities were evaluated in eight dyshormonogenetic goiters."3.69Thyroid peroxidase in dyshormonogenetic goiters with organification and thyroglobulin defects. ( de Carvalho, DP; Rego, KG; Rosenthal, D, 1994)
"Both lesion (L) and adjacent normal (N) thyroid tissue from 48 patients with non-functioning adenomas and adenomatous goitres were assayed for peroxidase activity by the 'mini' assay method employing guaiacol or iodide as the second substrate."3.67Peroxidase activity and thyroglobulin iodination activity of thyroid peroxidase in non-functioning thyroid tumours. ( Hosoya, T; Ito, K; Tarutani, O; Yoshimura, H, 1988)
"All of the 26 adenomatous goiters and 43 follicular adenomas were peroxidase-positive."1.28Histochemical determination of iodide peroxidase activity in various thyroid disorders. ( Akagi, M; Mori, K; Naito, M; Takahashi, K; Yamasaki, Y, 1990)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19903 (37.50)18.7374
1990's4 (50.00)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Freyberger, A1
Ahr, HJ1
de Carvalho, DP1
Rego, KG1
Rosenthal, D1
Hosaka, Y1
Ishii, T1
Suzuki, N1
Takamatsu, J1
Hirakawa, S1
Hosoya, T3
Ohmori, T1
Ieiri, T1
Asakura, Y1
Ohki, Y1
Teshirogi, T1
Terasaki, A1
Yamasaki, Y1
Mori, K1
Naito, M1
Akagi, M1
Takahashi, K1
Yoshimura, H1
Ito, K1
Tarutani, O1
Pommier, J1
Tourniaire, J1
Dème, D1
Chalendar, D1
Bornet, H1
Nunez, J1
Niepomniszcze, H1
Degroot, LJ1
Hagen, GA1

Trials

1 trial available for guaiacol and Goiter

ArticleYear
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value.
    Endocrine journal, 1993, Volume: 40, Issue:1

    Topics: Adolescent; Adult; Antibodies, Monoclonal; Blotting, Western; Catalysis; Chromatography, Affinity; C

1993

Other Studies

7 other studies available for guaiacol and Goiter

ArticleYear
Studies on the goitrogenic mechanism of action of N,N,N',N'-tetramethylthiourea.
    Toxicology, 2006, Jan-16, Volume: 217, Issue:2-3

    Topics: Amitrole; Animals; Antithyroid Agents; Chromatography, High Pressure Liquid; Dose-Response Relations

2006
Thyroid peroxidase in dyshormonogenetic goiters with organification and thyroglobulin defects.
    Thyroid : official journal of the American Thyroid Association, 1994,Winter, Volume: 4, Issue:4

    Topics: Blotting, Western; Electrophoresis, Polyacrylamide Gel; Goiter; Guaiacol; Humans; Iodide Peroxidase;

1994
Application of improved coupling assay method for peroxidase of diseased thyroids: report of three cases.
    Endocrinologia japonica, 1991, Volume: 38, Issue:1

    Topics: Adolescent; Adult; Child; DNA; Female; Goiter; Guaiacol; Humans; In Vitro Techniques; Iodide Peroxid

1991
Histochemical determination of iodide peroxidase activity in various thyroid disorders.
    American journal of surgery, 1990, Volume: 160, Issue:3

    Topics: Adenocarcinoma; Adenoma; Adult; Aged; Carcinoma, Papillary; Chi-Square Distribution; Female; Goiter;

1990
Peroxidase activity and thyroglobulin iodination activity of thyroid peroxidase in non-functioning thyroid tumours.
    Acta endocrinologica, 1988, Volume: 118, Issue:1

    Topics: Adenoma; Glucose Oxidase; Goiter; Guaiacol; Humans; Iodide Peroxidase; Iodine; Oxidation-Reduction;

1988
A defective thyroid peroxidase solubilized from a familial goiter with iodine organification defect.
    The Journal of clinical endocrinology and metabolism, 1974, Volume: 39, Issue:1

    Topics: Adult; Chromatography, DEAE-Cellulose; Digitonin; Female; Goiter; Guaiacol; Humans; Iodine; Molecula

1974
Abnormal thyroid peroxidase causing iodide organification defect.
    The Journal of clinical endocrinology and metabolism, 1972, Volume: 34, Issue:4

    Topics: Adolescent; Animals; Binding Sites; Cattle; Female; Goiter; Goiter, Nodular; Graves Disease; Guaiaco

1972