guaiacol and Goiter
guaiacol has been researched along with Goiter in 8 studies
Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)
methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.
guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.
Goiter: Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thyroid peroxidase (TPO) iodide and guaiacol oxidation activities were evaluated in eight dyshormonogenetic goiters." | 3.69 | Thyroid peroxidase in dyshormonogenetic goiters with organification and thyroglobulin defects. ( de Carvalho, DP; Rego, KG; Rosenthal, D, 1994) |
| "Both lesion (L) and adjacent normal (N) thyroid tissue from 48 patients with non-functioning adenomas and adenomatous goitres were assayed for peroxidase activity by the 'mini' assay method employing guaiacol or iodide as the second substrate." | 3.67 | Peroxidase activity and thyroglobulin iodination activity of thyroid peroxidase in non-functioning thyroid tumours. ( Hosoya, T; Ito, K; Tarutani, O; Yoshimura, H, 1988) |
| "All of the 26 adenomatous goiters and 43 follicular adenomas were peroxidase-positive." | 1.28 | Histochemical determination of iodide peroxidase activity in various thyroid disorders. ( Akagi, M; Mori, K; Naito, M; Takahashi, K; Yamasaki, Y, 1990) |
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Freyberger, A | 1 |
| Ahr, HJ | 1 |
| de Carvalho, DP | 1 |
| Rego, KG | 1 |
| Rosenthal, D | 1 |
| Hosaka, Y | 1 |
| Ishii, T | 1 |
| Suzuki, N | 1 |
| Takamatsu, J | 1 |
| Hirakawa, S | 1 |
| Hosoya, T | 3 |
| Ohmori, T | 1 |
| Ieiri, T | 1 |
| Asakura, Y | 1 |
| Ohki, Y | 1 |
| Teshirogi, T | 1 |
| Terasaki, A | 1 |
| Yamasaki, Y | 1 |
| Mori, K | 1 |
| Naito, M | 1 |
| Akagi, M | 1 |
| Takahashi, K | 1 |
| Yoshimura, H | 1 |
| Ito, K | 1 |
| Tarutani, O | 1 |
| Pommier, J | 1 |
| Tourniaire, J | 1 |
| Dème, D | 1 |
| Chalendar, D | 1 |
| Bornet, H | 1 |
| Nunez, J | 1 |
| Niepomniszcze, H | 1 |
| Degroot, LJ | 1 |
| Hagen, GA | 1 |
Trials
1 trial available for guaiacol and Goiter
| Article | Year |
|---|---|
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value.
Topics: Adolescent; Adult; Antibodies, Monoclonal; Blotting, Western; Catalysis; Chromatography, Affinity; C | 1993 |
Other Studies
7 other studies available for guaiacol and Goiter
| Article | Year |
|---|---|
Studies on the goitrogenic mechanism of action of N,N,N',N'-tetramethylthiourea.
Topics: Amitrole; Animals; Antithyroid Agents; Chromatography, High Pressure Liquid; Dose-Response Relations | 2006 |
Thyroid peroxidase in dyshormonogenetic goiters with organification and thyroglobulin defects.
Topics: Blotting, Western; Electrophoresis, Polyacrylamide Gel; Goiter; Guaiacol; Humans; Iodide Peroxidase; | 1994 |
Application of improved coupling assay method for peroxidase of diseased thyroids: report of three cases.
Topics: Adolescent; Adult; Child; DNA; Female; Goiter; Guaiacol; Humans; In Vitro Techniques; Iodide Peroxid | 1991 |
Histochemical determination of iodide peroxidase activity in various thyroid disorders.
Topics: Adenocarcinoma; Adenoma; Adult; Aged; Carcinoma, Papillary; Chi-Square Distribution; Female; Goiter; | 1990 |
Peroxidase activity and thyroglobulin iodination activity of thyroid peroxidase in non-functioning thyroid tumours.
Topics: Adenoma; Glucose Oxidase; Goiter; Guaiacol; Humans; Iodide Peroxidase; Iodine; Oxidation-Reduction; | 1988 |
A defective thyroid peroxidase solubilized from a familial goiter with iodine organification defect.
Topics: Adult; Chromatography, DEAE-Cellulose; Digitonin; Female; Goiter; Guaiacol; Humans; Iodine; Molecula | 1974 |
Abnormal thyroid peroxidase causing iodide organification defect.
Topics: Adolescent; Animals; Binding Sites; Cattle; Female; Goiter; Goiter, Nodular; Graves Disease; Guaiaco | 1972 |