guaiacol has been researched along with Disease Models, Animal in 29 studies
Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)
methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.
guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study aimed to investigate the effects of zingerone on some immune-related parameters in an animal model of breast cancer." | 8.02 | Zingerone improves the immune responses in an animal model of breast cancer. ( Hassan, ZM; Jafarzadeh, A; Kazemi, M; Khorramdelazad, H; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F, 2021) |
| "Gigantol and syringic acid (SA) have been shown to synergistically prevent formation of diabetic cataract (DC)." | 7.83 | Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( Chen, CY; Chen, D; Fang, H; Gao, X; Li, X; Long, Y; Wei, X; Wu, J; Yi, Y, 2016) |
| " Keeping this in mind, the present study was planned to evaluate the hepatoprotective potential of zingerone (active compound of zingiber officinale) against liver inflammation induced by antibiotic mediated endotoxemia." | 7.80 | Zingerone suppresses liver inflammation induced by antibiotic mediated endotoxemia through down regulating hepatic mRNA expression of inflammatory markers in Pseudomonas aeruginosa peritonitis mouse model. ( Chhibber, S; Harjai, K; Kumar, L, 2014) |
| "Zingerone (ZO) has been proven to be effective for many diseases." | 5.72 | Short-term treatment with zingerone ameliorates dextran sulfate sodium-induced mouse experimental colitis. ( Cui, Y; Huang, J; Liu, S; Liu, Y; Zhang, Z; Zhou, Y; Zhu, Z, 2022) |
| "Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with limited treatment options." | 5.56 | Zingerone ameliorates oxidative stress and inflammation in bleomycin-induced pulmonary fibrosis: modulation of the expression of TGF-β1 and iNOS. ( Arslanbas, E; Ekici, M; Gungor, H; Kara, H; Onder Karayigit, M; Turgut, NH, 2020) |
| "Zingerone pretreatment significantly (P<0." | 5.43 | Anti-inflammatory and anti-thrombotic effects of zingerone in a rat model of myocardial infarction. ( Hemalatha, KL; Stanely Mainzen Prince, P, 2016) |
| " This study aimed to investigate the effects of zingerone on some immune-related parameters in an animal model of breast cancer." | 4.02 | Zingerone improves the immune responses in an animal model of breast cancer. ( Hassan, ZM; Jafarzadeh, A; Kazemi, M; Khorramdelazad, H; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F, 2021) |
| "Gigantol and syringic acid (SA) have been shown to synergistically prevent formation of diabetic cataract (DC)." | 3.83 | Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( Chen, CY; Chen, D; Fang, H; Gao, X; Li, X; Long, Y; Wei, X; Wu, J; Yi, Y, 2016) |
| " Keeping this in mind, the present study was planned to evaluate the hepatoprotective potential of zingerone (active compound of zingiber officinale) against liver inflammation induced by antibiotic mediated endotoxemia." | 3.80 | Zingerone suppresses liver inflammation induced by antibiotic mediated endotoxemia through down regulating hepatic mRNA expression of inflammatory markers in Pseudomonas aeruginosa peritonitis mouse model. ( Chhibber, S; Harjai, K; Kumar, L, 2014) |
| "Zingerone (ZO) has been proven to be effective for many diseases." | 1.72 | Short-term treatment with zingerone ameliorates dextran sulfate sodium-induced mouse experimental colitis. ( Cui, Y; Huang, J; Liu, S; Liu, Y; Zhang, Z; Zhou, Y; Zhu, Z, 2022) |
| "Osteoporosis is characterized by the deterioration of bone structures and decreased bone mass, leading to an increased risk of fracture." | 1.62 | Anti-Osteoporotic Effects of ( Bak, SG; Cheong, SH; Lee, S; Lee, SJ; Lee, SW; Lim, HJ; Park, EJ; Rho, MC; Won, YS, 2021) |
| "Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with limited treatment options." | 1.56 | Zingerone ameliorates oxidative stress and inflammation in bleomycin-induced pulmonary fibrosis: modulation of the expression of TGF-β1 and iNOS. ( Arslanbas, E; Ekici, M; Gungor, H; Kara, H; Onder Karayigit, M; Turgut, NH, 2020) |
| "Guaiacol treatment in the APBD mouse model rescued grip strength and shorter lifespan." | 1.48 | Guaiacol as a drug candidate for treating adult polyglucosan body disease. ( Akman, HO; Alvarez, R; Escriba, P; Ferreira, I; Kakhlon, O; Khazanov, N; Lossos, A; Pampou, S; Senderowitz, H; Solmesky, LJ; Weil, M; Yetil, D; Yue, WW, 2018) |
| "Zingerone pretreatment significantly (P<0." | 1.43 | Anti-inflammatory and anti-thrombotic effects of zingerone in a rat model of myocardial infarction. ( Hemalatha, KL; Stanely Mainzen Prince, P, 2016) |
| "Pretreatment with zingerone (vanillyl acetone) revealed preventive effects on tachycardia, LVH, ECG, and all the above mentioned biochemical parameters evaluated in isoproterenol induced myocardial infarcted rats." | 1.42 | A biochemical and 2, 3, 5-triphenyl tetrazolium chloride staining study on the preventive effects of zingerone (vanillyl acetone) in experimentally induced myocardial infarcted rats. ( Hemalatha, KL; Stanely Mainzen Prince, P, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 18 (62.07) | 24.3611 |
| 2020's | 9 (31.03) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Margiotta, AL | 1 |
| Bain, LJ | 1 |
| Rice, CD | 1 |
| Chadwick, RW | 1 |
| George, SE | 1 |
| Kohan, MJ | 1 |
| Williams, RW | 1 |
| Allison, JC | 1 |
| Talley, DL | 1 |
| Hayes, YO | 1 |
| Chang, J | 1 |
| Lim, HJ | 1 |
| Park, EJ | 1 |
| Won, YS | 1 |
| Bak, SG | 1 |
| Cheong, SH | 1 |
| Lee, SW | 1 |
| Lee, S | 1 |
| Lee, SJ | 1 |
| Rho, MC | 1 |
| Zhu, Y | 2 |
| Wang, D | 1 |
| Luo, J | 2 |
| Jie, J | 1 |
| Liu, H | 2 |
| Peng, L | 2 |
| Bai, X | 1 |
| Li, D | 2 |
| Zhang, Z | 2 |
| Cui, Y | 1 |
| Liu, S | 1 |
| Huang, J | 1 |
| Liu, Y | 1 |
| Zhou, Y | 1 |
| Zhu, Z | 1 |
| Chen, X | 1 |
| Chen, J | 1 |
| Miao, C | 1 |
| Yin, G | 1 |
| Sun, R | 1 |
| Ni, S | 1 |
| Gungor, H | 1 |
| Ekici, M | 1 |
| Onder Karayigit, M | 1 |
| Turgut, NH | 1 |
| Kara, H | 1 |
| Arslanbas, E | 1 |
| Sharma, K | 1 |
| Bose, SK | 1 |
| Chhibber, S | 2 |
| Harjai, K | 2 |
| Kazemi, M | 1 |
| Jafarzadeh, A | 1 |
| Nemati, M | 1 |
| Taghipour, F | 1 |
| Oladpour, O | 1 |
| Rezayati, MT | 1 |
| Khorramdelazad, H | 1 |
| Hassan, ZM | 1 |
| Wang, C | 1 |
| Hua, S | 1 |
| Song, L | 1 |
| Mani, V | 1 |
| Arivalagan, S | 1 |
| Islam Siddique, A | 1 |
| Namasivayam, N | 1 |
| Lee, W | 1 |
| Ku, SK | 2 |
| Bae, JS | 2 |
| Lee, BS | 1 |
| Lee, C | 1 |
| Yang, S | 1 |
| Kakhlon, O | 1 |
| Ferreira, I | 1 |
| Solmesky, LJ | 1 |
| Khazanov, N | 1 |
| Lossos, A | 1 |
| Alvarez, R | 1 |
| Yetil, D | 1 |
| Pampou, S | 1 |
| Weil, M | 1 |
| Senderowitz, H | 1 |
| Escriba, P | 1 |
| Yue, WW | 1 |
| Akman, HO | 1 |
| Belcher, JD | 1 |
| Young, M | 1 |
| Chen, C | 1 |
| Nguyen, J | 1 |
| Burhop, K | 1 |
| Tran, P | 1 |
| Vercellotti, GM | 1 |
| Elseweidy, MM | 1 |
| Abdallah, FR | 1 |
| Younis, NN | 1 |
| Aldohmy, S | 1 |
| Kassem, HM | 1 |
| Kumar, L | 1 |
| El-Seweidy, MM | 1 |
| Asker, Mel-S | 1 |
| Eldahmy, SI | 1 |
| Atteia, HH | 1 |
| Abdallah, MA | 1 |
| Hemalatha, KL | 2 |
| Stanely Mainzen Prince, P | 2 |
| Choi, JS | 2 |
| Bae, WY | 2 |
| Park, C | 2 |
| Jeong, JW | 2 |
| Kim, JE | 1 |
| Wu, J | 1 |
| Li, X | 1 |
| Fang, H | 1 |
| Yi, Y | 1 |
| Chen, D | 1 |
| Long, Y | 1 |
| Gao, X | 1 |
| Wei, X | 1 |
| Chen, CY | 1 |
| Lee, EJ | 2 |
| Chen, HY | 1 |
| Hung, YC | 1 |
| Chen, TY | 2 |
| Lee, MY | 1 |
| Yu, SC | 1 |
| Chen, YH | 1 |
| Chuang, IC | 1 |
| Wu, TS | 2 |
| Morimoto, Y | 1 |
| Shibata, Y | 1 |
| Tai, SH | 1 |
| Huang, CC | 1 |
| Lee, AC | 1 |
| Huang, SY | 1 |
| Bhardwaj, A | 1 |
| Kabuto, H | 1 |
| Yamanushi, TT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2 Multi-center, Randomized, Double-blind, Comparator-Controlled Dose Finding Study to Evaluate MP4CO for the Acute Treatment of Vaso-occlusive Crises in Subjects With Sickle Cell Disease[NCT01925001] | Phase 2 | 0 participants (Actual) | Interventional | 2013-10-31 | Withdrawn (stopped due to Sangart ceased operations) | ||
| Production of Fortified Biscuit With Chickpea and Crushed Peanut and Evaluating Its Effectiveness in Terms of Its Acceptability and Cognitive Performance: a Pilot Study Among Egyptian Primary School-aged Children[NCT05281146] | 80 participants (Actual) | Interventional | 2018-11-26 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
29 other studies available for guaiacol and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Expression of the Major Vault Protein (MVP) and Cellular Vault Particles in Fish.
Topics: Animals; Catfishes; Cell Line; Creosote; Disease Models, Animal; Ethidium; Female; Fundulidae; Gene | 2017 |
Potentiation of 2,6-dinitrotoluene genotoxicity in Fischer 344 rats by pretreatment with coal tar creosote.
Topics: Analysis of Variance; Animals; Bacteria, Aerobic; Bacteria, Anaerobic; Cecum; Chromatography, Gas; C | 1995 |
Anti-Osteoporotic Effects of
Topics: Acrylamides; Animals; Biomarkers; Bone Resorption; Cell Differentiation; Disease Models, Animal; Fem | 2021 |
Zingerone Inhibits the Neutrophil Extracellular Trap Formation and Protects against Sepsis via Nrf2-Mediated ROS Inhibition.
Topics: Animals; Blood Donors; Cells, Cultured; Cytokines; Disease Models, Animal; Extracellular Traps; Guai | 2022 |
Short-term treatment with zingerone ameliorates dextran sulfate sodium-induced mouse experimental colitis.
Topics: Animals; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Guaiacol; Mice; Mice, I | 2022 |
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Topics: Animals; Apoptosis; Chondrocytes; Disease Models, Animal; Ferroptosis; Guaiacol; Mice | 2023 |
Zingerone ameliorates oxidative stress and inflammation in bleomycin-induced pulmonary fibrosis: modulation of the expression of TGF-β1 and iNOS.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Bleomycin; Disease Models, Animal; Guaiacol; Inflam | 2020 |
Exploring the Therapeutic Efficacy of Zingerone Nanoparticles in Treating Biofilm-Associated Pyelonephritis Caused by Pseudomonas aeruginosa in the Murine Model.
Topics: Animals; Biofilms; Disease Models, Animal; Guaiacol; HEK293 Cells; Humans; Inflammation; Malondialde | 2020 |
Zingerone improves the immune responses in an animal model of breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Guaiacol; Immunity; Mic | 2021 |
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Asthma; Disease Models, Animal; Gu | 2021 |
Antihyperlipidemic and antiapoptotic potential of zingerone on alcohol induced hepatotoxicity in experimental rats.
Topics: Acyl Coenzyme A; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Disease Model | 2017 |
Zingerone reduces HMGB1-mediated septic responses and improves survival in septic mice.
Topics: Acetylation; Animals; Anti-Inflammatory Agents; Capillary Permeability; Cell Adhesion Molecules; Cel | 2017 |
Renal protective effects of zingerone in a mouse model of sepsis.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Disease Models, Animal; Glutathione Peroxidase; Guaiacol | 2019 |
Guaiacol as a drug candidate for treating adult polyglucosan body disease.
Topics: Animals; Disease Models, Animal; Dual-Specificity Phosphatases; Fibroblasts; Glucans; Glucose; Glyco | 2018 |
MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice.
Topics: Anemia, Sickle Cell; Animals; Carbon Monoxide; Disease Models, Animal; Female; Guaiacol; Heme Oxygen | 2013 |
10-Dehydrogingerdione raises HDL-cholesterol through a CETP inhibition and wards off oxidation and inflammation in dyslipidemic rabbits.
Topics: Animals; Atorvastatin; C-Reactive Protein; Cell Proliferation; Cholesterol Ester Transfer Proteins; | 2013 |
Zingerone suppresses liver inflammation induced by antibiotic mediated endotoxemia through down regulating hepatic mRNA expression of inflammatory markers in Pseudomonas aeruginosa peritonitis mouse model.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Endotoxemia; Endotoxins; Gene Expression Reg | 2014 |
Haemostatic risk factors in dyslipidemic rabbits: role of 10-dehydrogingerdione as a new hypolipemic agent.
Topics: Animals; Anticholesteremic Agents; Atherosclerosis; Atorvastatin; Blood Coagulation; Cholesterol Est | 2015 |
A biochemical and 2, 3, 5-triphenyl tetrazolium chloride staining study on the preventive effects of zingerone (vanillyl acetone) in experimentally induced myocardial infarcted rats.
Topics: Adenosine Triphosphatases; Animals; Biomarkers; Coloring Agents; Disease Models, Animal; Electrocard | 2015 |
Zingerone activates VMAT2 during MPP(+) -induced Cell Death.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Death; Corpus Striatum; Disease Models, | 2015 |
Zingerone suppresses angiogenesis via inhibition of matrix metalloproteinases during tumor development.
Topics: Animals; Cell Growth Processes; Disease Models, Animal; Guaiacol; Hypoxia-Inducible Factor 1, alpha | 2016 |
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract.
Topics: Aldehyde Reductase; Animals; Bibenzyls; Cataract; Cell Line; Cell Survival; Diabetes Complications; | 2016 |
Anti-inflammatory and anti-thrombotic effects of zingerone in a rat model of myocardial infarction.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Disease Models, Animal; Fibrinolytic Agents; Glyceral | 2016 |
Therapeutic window for cinnamophilin following oxygen-glucose deprivation and transient focal cerebral ischemia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Benzothiazoles; Body Weight; Cell Lin | 2009 |
Effects of various fragrant ingredients on desmopressin-induced fluid retention in mice.
Topics: Animals; Aromatherapy; Cyclohexenes; Deamino Arginine Vasopressin; Disease Models, Animal; Diuretics | 2010 |
Cinnamophilin offers prolonged neuroprotection against gray and white matter damage and improves functional and electrophysiological outcomes after transient focal cerebral ischemia.
Topics: Animals; Antioxidants; Behavior, Animal; Body Weight; Brain; Cerebral Cortex; Confidence Intervals; | 2011 |
Experimental studies on ischemic neuroprotection: criteria for translational significance.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Disease Progression; Electrophysiology; Evoked Pote | 2011 |
Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson's disease mouse model.
Topics: Animals; Antioxidants; Ascorbic Acid; Catalase; Corpus Striatum; Disease Models, Animal; Dopamine; E | 2011 |