guaiacol has been researched along with Chemical and Drug Induced Liver Injury in 8 studies
Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)
methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.
guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vancomycin (VCM) is a glycopeptide antibiotic widely used to treat serious infections caused by methicillin-resistant Staphylococcus aureus and has been associated with some severe side effects such as hepatotoxicity and nephrotoxicity." | 5.56 | Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis. ( Ayna, A; Caglayan, C; Darendelioğlu, E; Kandemir, FM; Kucukler, S; Yıldırım, S, 2020) |
| "Vancomycin (VCM) is a glycopeptide antibiotic widely used to treat serious infections caused by methicillin-resistant Staphylococcus aureus and has been associated with some severe side effects such as hepatotoxicity and nephrotoxicity." | 1.56 | Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis. ( Ayna, A; Caglayan, C; Darendelioğlu, E; Kandemir, FM; Kucukler, S; Yıldırım, S, 2020) |
| "Zingerone treatment attenuated CCl4-induced increases in inflammatory mediators, including tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2, and inducible nitric oxide synthase mRNA levels." | 1.43 | Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats. ( Bak, J; Cheong, KO; Chung, HY; Je, NK; Kim, KW; Lee, C; Moon, JO; Shin, DS; Yoon, S, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Alderman, S | 1 |
| Kailas, S | 1 |
| Goldfarb, S | 1 |
| Singaram, C | 1 |
| Malone, DG | 1 |
| Malins, DC | 1 |
| Krahn, MM | 1 |
| Myers, MS | 1 |
| Rhodes, LD | 1 |
| Brown, DW | 1 |
| Krone, CA | 1 |
| McCain, BB | 1 |
| Chan, SL | 1 |
| Xue, YR | 1 |
| Yao, S | 1 |
| Liu, Q | 1 |
| Peng, ZL | 1 |
| Deng, QQ | 1 |
| Liu, B | 1 |
| Ma, ZH | 1 |
| Wang, L | 1 |
| Zhou, H | 1 |
| Ye, Y | 1 |
| Pan, GY | 1 |
| Kucukler, S | 1 |
| Darendelioğlu, E | 1 |
| Caglayan, C | 1 |
| Ayna, A | 1 |
| Yıldırım, S | 1 |
| Kandemir, FM | 1 |
| Cheong, KO | 1 |
| Shin, DS | 1 |
| Bak, J | 1 |
| Lee, C | 1 |
| Kim, KW | 1 |
| Je, NK | 1 |
| Chung, HY | 1 |
| Yoon, S | 1 |
| Moon, JO | 1 |
| Mani, V | 1 |
| Arivalagan, S | 1 |
| Siddique, AI | 1 |
| Namasivayam, N | 1 |
| Byun, E | 1 |
| Jeong, GS | 1 |
| An, RB | 1 |
| Min, TS | 1 |
| Kim, YC | 1 |
8 other studies available for guaiacol and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Cholestatic hepatitis after ingestion of chaparral leaf: confirmation by endoscopic retrograde cholangiopancreatography and liver biopsy.
Topics: Alcoholism; Biopsy; Chemical and Drug Induced Liver Injury; Cholangiopancreatography, Endoscopic Ret | 1994 |
Toxic chemicals in sediments and biota from a creosote-polluted harbor: relationships with hepatic neoplasms and other hepatic lesions in English sole (Parophrys vetulus).
Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Creosote; Cresols; Diet; | 1985 |
Dihydro-stilbene gigantol relieves CCl
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Bibenzyls; Carbon Tetrachlori | 2020 |
Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis.
Topics: Animals; Apoptosis; Blotting, Western; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Gua | 2020 |
Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; | 2016 |
Antioxidant and anti-inflammatory role of zingerone in ethanol-induced hepatotoxicity.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Ethanol; Gene Expression Regulation; | 2016 |
Tribuli fructus constituents protect against tacrine-induced cytotoxicity in HepG2 cells.
Topics: Carbohydrate Sequence; Cell Line; Chemical and Drug Induced Liver Injury; Fruit; Guaiacol; Imides; M | 2010 |