Page last updated: 2024-10-17

guaiacol and Cataract

guaiacol has been researched along with Cataract in 6 studies

Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)
methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.
guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.

Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"Gigantol and syringic acid (SA) have been shown to synergistically prevent formation of diabetic cataract (DC)."7.83Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( Chen, CY; Chen, D; Fang, H; Gao, X; Li, X; Long, Y; Wei, X; Wu, J; Yi, Y, 2016)
"As a continuation of our efforts directed towards the development of natural anti-diabetic cataract agents, gigantol was isolated from Herba dendrobii and was found to inhibit both aldose reductase (AR) and inducible nitric oxide synthase (iNOS) activity, which play a significant role in the development and progression of diabetic cataracts."7.81Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract. ( Chen, CY; Fang, H; Hu, X; Li, X; Lu, C; Sun, X; Wan, W; Wang, M; Wei, X; Wu, J; Yang, Q, 2015)
"To study the anti-cataract effect of gigantol combined with syringic acid and their action mechanism."7.78[Study on anti-cataract effect of gigantol combined with syringic acid and their mechanism]. ( Diao, H; Fang, H; Gao, X; Gu, L; Gu, Q; Qi, H; Wang, L; Wang, Z; Wei, X; Yi, Y, 2012)
"Gigantol was found to prevent galactose-induced damage to the rat lenses both in vitro and in vivo, to delay lens turbidity, and to keep the lenses transparent."5.42Anti-osmotic and antioxidant activities of gigantol from Dendrobium aurantiacum var. denneanum against cataractogenesis in galactosemic rats. ( Fang, H; Gao, X; Gu, L; Gu, Q; Hu, X; Oliver Chen, CY; Sun, X; Wan, W; Wang, M; Wang, Z; Wei, X; Yang, Q, 2015)
"We previously reported that gigantol extracted from Caulis Dendrobii has significant therapeutic benefits for the treatment of galactosemic cataracts through its ability to inhibit aldose reductase (AR) activity."3.91Characterization of structural requirement for binding of gigantol and aldose reductase. ( Wan, W; Wei, X; Yang, Q; Yang, Y; Yu, J, 2019)
"Gigantol and syringic acid (SA) have been shown to synergistically prevent formation of diabetic cataract (DC)."3.83Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( Chen, CY; Chen, D; Fang, H; Gao, X; Li, X; Long, Y; Wei, X; Wu, J; Yi, Y, 2016)
"As a continuation of our efforts directed towards the development of natural anti-diabetic cataract agents, gigantol was isolated from Herba dendrobii and was found to inhibit both aldose reductase (AR) and inducible nitric oxide synthase (iNOS) activity, which play a significant role in the development and progression of diabetic cataracts."3.81Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract. ( Chen, CY; Fang, H; Hu, X; Li, X; Lu, C; Sun, X; Wan, W; Wang, M; Wei, X; Wu, J; Yang, Q, 2015)
"To study the anti-cataract effect of gigantol combined with syringic acid and their action mechanism."3.78[Study on anti-cataract effect of gigantol combined with syringic acid and their mechanism]. ( Diao, H; Fang, H; Gao, X; Gu, L; Gu, Q; Qi, H; Wang, L; Wang, Z; Wei, X; Yi, Y, 2012)
"Gigantol was found to prevent galactose-induced damage to the rat lenses both in vitro and in vivo, to delay lens turbidity, and to keep the lenses transparent."1.42Anti-osmotic and antioxidant activities of gigantol from Dendrobium aurantiacum var. denneanum against cataractogenesis in galactosemic rats. ( Fang, H; Gao, X; Gu, L; Gu, Q; Hu, X; Oliver Chen, CY; Sun, X; Wan, W; Wang, M; Wang, Z; Wei, X; Yang, Q, 2015)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yang, Y1
Yang, Q4
Yu, J1
Wan, W4
Wei, X6
Fang, H4
Hu, X2
Wang, M2
Sun, X2
Gu, Q2
Gao, X3
Wang, Z2
Gu, L2
Oliver Chen, CY1
Wu, J3
Lu, C1
Li, X3
Chen, CY2
Yi, Y2
Chen, D2
Long, Y1
Ma, W1
Hu, J1
Chen, CO1
Diao, H1
Qi, H1
Wang, L1

Other Studies

6 other studies available for guaiacol and Cataract

ArticleYear
Characterization of structural requirement for binding of gigantol and aldose reductase.
    Frontiers in bioscience (Landmark edition), 2019, 03-01, Volume: 24, Issue:6

    Topics: Aldehyde Reductase; Animals; Bibenzyls; Binding Sites; Catalysis; Cataract; Female; Guaiacol; Lens,

2019
Anti-osmotic and antioxidant activities of gigantol from Dendrobium aurantiacum var. denneanum against cataractogenesis in galactosemic rats.
    Journal of ethnopharmacology, 2015, Aug-22, Volume: 172

    Topics: Animals; Antioxidants; Bibenzyls; Cataract; Dendrobium; Drugs, Chinese Herbal; Galactosemias; Guaiac

2015
Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Aldehyde Reductase; Apoptosis; Bibenzyls; Cataract; Cell Survival; Cells, Cultured; Diabetes Complic

2015
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract.
    BMC complementary and alternative medicine, 2016, Aug-12, Volume: 16, Issue:1

    Topics: Aldehyde Reductase; Animals; Bibenzyls; Cataract; Cell Line; Cell Survival; Diabetes Complications;

2016
Gigantol from Dendrobium chrysotoxum Lindl. binds and inhibits aldose reductase gene to exert its anti-cataract activity: An in vitro mechanistic study.
    Journal of ethnopharmacology, 2017, Feb-23, Volume: 198

    Topics: Aldehyde Reductase; Bibenzyls; Cataract; Cells, Cultured; Dendrobium; Diabetes Complications; Epithe

2017
[Study on anti-cataract effect of gigantol combined with syringic acid and their mechanism].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012, Volume: 37, Issue:16

    Topics: Aldehyde Reductase; Animals; Bibenzyls; Cataract; Drug Synergism; Female; Gallic Acid; Guaiacol; Hum

2012