guaiacol has been researched along with Cataract in 6 studies
Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)
methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.
guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gigantol and syringic acid (SA) have been shown to synergistically prevent formation of diabetic cataract (DC)." | 7.83 | Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( Chen, CY; Chen, D; Fang, H; Gao, X; Li, X; Long, Y; Wei, X; Wu, J; Yi, Y, 2016) |
| "As a continuation of our efforts directed towards the development of natural anti-diabetic cataract agents, gigantol was isolated from Herba dendrobii and was found to inhibit both aldose reductase (AR) and inducible nitric oxide synthase (iNOS) activity, which play a significant role in the development and progression of diabetic cataracts." | 7.81 | Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract. ( Chen, CY; Fang, H; Hu, X; Li, X; Lu, C; Sun, X; Wan, W; Wang, M; Wei, X; Wu, J; Yang, Q, 2015) |
| "To study the anti-cataract effect of gigantol combined with syringic acid and their action mechanism." | 7.78 | [Study on anti-cataract effect of gigantol combined with syringic acid and their mechanism]. ( Diao, H; Fang, H; Gao, X; Gu, L; Gu, Q; Qi, H; Wang, L; Wang, Z; Wei, X; Yi, Y, 2012) |
| "Gigantol was found to prevent galactose-induced damage to the rat lenses both in vitro and in vivo, to delay lens turbidity, and to keep the lenses transparent." | 5.42 | Anti-osmotic and antioxidant activities of gigantol from Dendrobium aurantiacum var. denneanum against cataractogenesis in galactosemic rats. ( Fang, H; Gao, X; Gu, L; Gu, Q; Hu, X; Oliver Chen, CY; Sun, X; Wan, W; Wang, M; Wang, Z; Wei, X; Yang, Q, 2015) |
| "We previously reported that gigantol extracted from Caulis Dendrobii has significant therapeutic benefits for the treatment of galactosemic cataracts through its ability to inhibit aldose reductase (AR) activity." | 3.91 | Characterization of structural requirement for binding of gigantol and aldose reductase. ( Wan, W; Wei, X; Yang, Q; Yang, Y; Yu, J, 2019) |
| "Gigantol and syringic acid (SA) have been shown to synergistically prevent formation of diabetic cataract (DC)." | 3.83 | Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( Chen, CY; Chen, D; Fang, H; Gao, X; Li, X; Long, Y; Wei, X; Wu, J; Yi, Y, 2016) |
| "As a continuation of our efforts directed towards the development of natural anti-diabetic cataract agents, gigantol was isolated from Herba dendrobii and was found to inhibit both aldose reductase (AR) and inducible nitric oxide synthase (iNOS) activity, which play a significant role in the development and progression of diabetic cataracts." | 3.81 | Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract. ( Chen, CY; Fang, H; Hu, X; Li, X; Lu, C; Sun, X; Wan, W; Wang, M; Wei, X; Wu, J; Yang, Q, 2015) |
| "To study the anti-cataract effect of gigantol combined with syringic acid and their action mechanism." | 3.78 | [Study on anti-cataract effect of gigantol combined with syringic acid and their mechanism]. ( Diao, H; Fang, H; Gao, X; Gu, L; Gu, Q; Qi, H; Wang, L; Wang, Z; Wei, X; Yi, Y, 2012) |
| "Gigantol was found to prevent galactose-induced damage to the rat lenses both in vitro and in vivo, to delay lens turbidity, and to keep the lenses transparent." | 1.42 | Anti-osmotic and antioxidant activities of gigantol from Dendrobium aurantiacum var. denneanum against cataractogenesis in galactosemic rats. ( Fang, H; Gao, X; Gu, L; Gu, Q; Hu, X; Oliver Chen, CY; Sun, X; Wan, W; Wang, M; Wang, Z; Wei, X; Yang, Q, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Y | 1 |
| Yang, Q | 4 |
| Yu, J | 1 |
| Wan, W | 4 |
| Wei, X | 6 |
| Fang, H | 4 |
| Hu, X | 2 |
| Wang, M | 2 |
| Sun, X | 2 |
| Gu, Q | 2 |
| Gao, X | 3 |
| Wang, Z | 2 |
| Gu, L | 2 |
| Oliver Chen, CY | 1 |
| Wu, J | 3 |
| Lu, C | 1 |
| Li, X | 3 |
| Chen, CY | 2 |
| Yi, Y | 2 |
| Chen, D | 2 |
| Long, Y | 1 |
| Ma, W | 1 |
| Hu, J | 1 |
| Chen, CO | 1 |
| Diao, H | 1 |
| Qi, H | 1 |
| Wang, L | 1 |
6 other studies available for guaiacol and Cataract
| Article | Year |
|---|---|
Characterization of structural requirement for binding of gigantol and aldose reductase.
Topics: Aldehyde Reductase; Animals; Bibenzyls; Binding Sites; Catalysis; Cataract; Female; Guaiacol; Lens, | 2019 |
Anti-osmotic and antioxidant activities of gigantol from Dendrobium aurantiacum var. denneanum against cataractogenesis in galactosemic rats.
Topics: Animals; Antioxidants; Bibenzyls; Cataract; Dendrobium; Drugs, Chinese Herbal; Galactosemias; Guaiac | 2015 |
Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract.
Topics: Aldehyde Reductase; Apoptosis; Bibenzyls; Cataract; Cell Survival; Cells, Cultured; Diabetes Complic | 2015 |
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract.
Topics: Aldehyde Reductase; Animals; Bibenzyls; Cataract; Cell Line; Cell Survival; Diabetes Complications; | 2016 |
Gigantol from Dendrobium chrysotoxum Lindl. binds and inhibits aldose reductase gene to exert its anti-cataract activity: An in vitro mechanistic study.
Topics: Aldehyde Reductase; Bibenzyls; Cataract; Cells, Cultured; Dendrobium; Diabetes Complications; Epithe | 2017 |
[Study on anti-cataract effect of gigantol combined with syringic acid and their mechanism].
Topics: Aldehyde Reductase; Animals; Bibenzyls; Cataract; Drug Synergism; Female; Gallic Acid; Guaiacol; Hum | 2012 |