guaiacol has been researched along with Cataract, Membranous in 6 studies
Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)
methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.
guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gigantol and syringic acid (SA) have been shown to synergistically prevent formation of diabetic cataract (DC)." | 7.83 | Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( Chen, CY; Chen, D; Fang, H; Gao, X; Li, X; Long, Y; Wei, X; Wu, J; Yi, Y, 2016) |
| "As a continuation of our efforts directed towards the development of natural anti-diabetic cataract agents, gigantol was isolated from Herba dendrobii and was found to inhibit both aldose reductase (AR) and inducible nitric oxide synthase (iNOS) activity, which play a significant role in the development and progression of diabetic cataracts." | 7.81 | Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract. ( Chen, CY; Fang, H; Hu, X; Li, X; Lu, C; Sun, X; Wan, W; Wang, M; Wei, X; Wu, J; Yang, Q, 2015) |
| "To study the anti-cataract effect of gigantol combined with syringic acid and their action mechanism." | 7.78 | [Study on anti-cataract effect of gigantol combined with syringic acid and their mechanism]. ( Diao, H; Fang, H; Gao, X; Gu, L; Gu, Q; Qi, H; Wang, L; Wang, Z; Wei, X; Yi, Y, 2012) |
| "Gigantol was found to prevent galactose-induced damage to the rat lenses both in vitro and in vivo, to delay lens turbidity, and to keep the lenses transparent." | 5.42 | Anti-osmotic and antioxidant activities of gigantol from Dendrobium aurantiacum var. denneanum against cataractogenesis in galactosemic rats. ( Fang, H; Gao, X; Gu, L; Gu, Q; Hu, X; Oliver Chen, CY; Sun, X; Wan, W; Wang, M; Wang, Z; Wei, X; Yang, Q, 2015) |
| "We previously reported that gigantol extracted from Caulis Dendrobii has significant therapeutic benefits for the treatment of galactosemic cataracts through its ability to inhibit aldose reductase (AR) activity." | 3.91 | Characterization of structural requirement for binding of gigantol and aldose reductase. ( Wan, W; Wei, X; Yang, Q; Yang, Y; Yu, J, 2019) |
| "Gigantol and syringic acid (SA) have been shown to synergistically prevent formation of diabetic cataract (DC)." | 3.83 | Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( Chen, CY; Chen, D; Fang, H; Gao, X; Li, X; Long, Y; Wei, X; Wu, J; Yi, Y, 2016) |
| "As a continuation of our efforts directed towards the development of natural anti-diabetic cataract agents, gigantol was isolated from Herba dendrobii and was found to inhibit both aldose reductase (AR) and inducible nitric oxide synthase (iNOS) activity, which play a significant role in the development and progression of diabetic cataracts." | 3.81 | Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract. ( Chen, CY; Fang, H; Hu, X; Li, X; Lu, C; Sun, X; Wan, W; Wang, M; Wei, X; Wu, J; Yang, Q, 2015) |
| "To study the anti-cataract effect of gigantol combined with syringic acid and their action mechanism." | 3.78 | [Study on anti-cataract effect of gigantol combined with syringic acid and their mechanism]. ( Diao, H; Fang, H; Gao, X; Gu, L; Gu, Q; Qi, H; Wang, L; Wang, Z; Wei, X; Yi, Y, 2012) |
| "Gigantol was found to prevent galactose-induced damage to the rat lenses both in vitro and in vivo, to delay lens turbidity, and to keep the lenses transparent." | 1.42 | Anti-osmotic and antioxidant activities of gigantol from Dendrobium aurantiacum var. denneanum against cataractogenesis in galactosemic rats. ( Fang, H; Gao, X; Gu, L; Gu, Q; Hu, X; Oliver Chen, CY; Sun, X; Wan, W; Wang, M; Wang, Z; Wei, X; Yang, Q, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Y | 1 |
| Yang, Q | 4 |
| Yu, J | 1 |
| Wan, W | 4 |
| Wei, X | 6 |
| Fang, H | 4 |
| Hu, X | 2 |
| Wang, M | 2 |
| Sun, X | 2 |
| Gu, Q | 2 |
| Gao, X | 3 |
| Wang, Z | 2 |
| Gu, L | 2 |
| Oliver Chen, CY | 1 |
| Wu, J | 3 |
| Lu, C | 1 |
| Li, X | 3 |
| Chen, CY | 2 |
| Yi, Y | 2 |
| Chen, D | 2 |
| Long, Y | 1 |
| Ma, W | 1 |
| Hu, J | 1 |
| Chen, CO | 1 |
| Diao, H | 1 |
| Qi, H | 1 |
| Wang, L | 1 |
6 other studies available for guaiacol and Cataract, Membranous
| Article | Year |
|---|---|
Characterization of structural requirement for binding of gigantol and aldose reductase.
Topics: Aldehyde Reductase; Animals; Bibenzyls; Binding Sites; Catalysis; Cataract; Female; Guaiacol; Lens, | 2019 |
Anti-osmotic and antioxidant activities of gigantol from Dendrobium aurantiacum var. denneanum against cataractogenesis in galactosemic rats.
Topics: Animals; Antioxidants; Bibenzyls; Cataract; Dendrobium; Drugs, Chinese Herbal; Galactosemias; Guaiac | 2015 |
Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract.
Topics: Aldehyde Reductase; Apoptosis; Bibenzyls; Cataract; Cell Survival; Cells, Cultured; Diabetes Complic | 2015 |
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract.
Topics: Aldehyde Reductase; Animals; Bibenzyls; Cataract; Cell Line; Cell Survival; Diabetes Complications; | 2016 |
Gigantol from Dendrobium chrysotoxum Lindl. binds and inhibits aldose reductase gene to exert its anti-cataract activity: An in vitro mechanistic study.
Topics: Aldehyde Reductase; Bibenzyls; Cataract; Cells, Cultured; Dendrobium; Diabetes Complications; Epithe | 2017 |
[Study on anti-cataract effect of gigantol combined with syringic acid and their mechanism].
Topics: Aldehyde Reductase; Animals; Bibenzyls; Cataract; Drug Synergism; Female; Gallic Acid; Guaiacol; Hum | 2012 |