gsk343 and Triple-Negative-Breast-Neoplasms

gsk343 has been researched along with Triple-Negative-Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for gsk343 and Triple-Negative-Breast-Neoplasms

Article	Year
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer. Theranostics, 2019, Volume: 9, Issue:3 Triple-negative breast cancer (TNBC) cells lack the expression of ER, PR and HER2. Thus, TNBC patients cannot benefit from hormone receptor-targeted therapy as non-TNBC patients, but can only receive chemotherapy as the systemic treatment and have a worse overall outcome. More effective therapeutic targets and combination therapy strategies are urgently needed to improve the treatment effectiveness. Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cancer Survivors; Cell Line, Tumor; Cellular Senescence; DNA Methylation; DNA, Neoplasm; Doxorubicin; Drug Delivery Systems; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Mice; Mice, Nude; Mixed Function Oxygenases; Proto-Oncogene Proteins; Pyridones; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays	2019

Article

Year

Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer.

Theranostics, 2019, Volume: 9, Issue:3

Triple-negative breast cancer (TNBC) cells lack the expression of ER, PR and HER2. Thus, TNBC patients cannot benefit from hormone receptor-targeted therapy as non-TNBC patients, but can only receive chemotherapy as the systemic treatment and have a worse overall outcome. More effective therapeutic targets and combination therapy strategies are urgently needed to improve the treatment effectiveness.

Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cancer Survivors; Cell Line, Tumor; Cellular Senescence; DNA Methylation; DNA, Neoplasm; Doxorubicin; Drug Delivery Systems; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Mice; Mice, Nude; Mixed Function Oxygenases; Proto-Oncogene Proteins; Pyridones; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2019