gsk299423 and Lung-Diseases

gsk299423 has been researched along with Lung-Diseases* in 1 studies

Other Studies

1 other study(ies) available for gsk299423 and Lung-Diseases

Article	Year
Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases. Bioorganic & medicinal chemistry letters, 2011, Dec-15, Volume: 21, Issue:24 We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad spectrum antibacterial activity and demonstrates oral efficacy in a rat lung infection model. Topics: Animals; Anti-Bacterial Agents; Dioxanes; Disease Models, Animal; DNA Topoisomerases, Type II; Dogs; Haplorhini; Humans; Lung Diseases; Microbial Sensitivity Tests; Naphthyridines; Piperidines; Rats; Structure-Activity Relationship; Topoisomerase II Inhibitors	2011

Article

Year

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases.

Bioorganic & medicinal chemistry letters, 2011, Dec-15, Volume: 21, Issue:24

We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad spectrum antibacterial activity and demonstrates oral efficacy in a rat lung infection model.

Topics: Animals; Anti-Bacterial Agents; Dioxanes; Disease Models, Animal; DNA Topoisomerases, Type II; Dogs; Haplorhini; Humans; Lung Diseases; Microbial Sensitivity Tests; Naphthyridines; Piperidines; Rats; Structure-Activity Relationship; Topoisomerase II Inhibitors

2011