gsk299423 has been researched along with Bacterial-Infections* in 1 studies
1 other study(ies) available for gsk299423 and Bacterial-Infections
| Article | Year |
|---|---|
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.
Bacterial resistance is increasing rapidly, requiring urgent identification of new antibacterial drugs that are effective against multidrug-resistant pathogens. Novel bacterial topoisomerase inhibitors (NBTIs) provide a new strategy for investigating the well-validated DNA gyrase and topoisomerase IV targets while preventing cross-resistance issues. On this basis, starting from a virtual screening campaign and subsequent structure-based hit optimization guided by X-ray studies, a novel class of piperazine-like NBTIs with outstanding enzymatic activity against Topics: Amino Acid Sequence; Bacterial Infections; DNA Gyrase; DNA Topoisomerase IV; Escherichia coli; Microbial Sensitivity Tests; Models, Chemical; Molecular Structure; Sequence Homology, Amino Acid; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase Inhibitors | 2019 |