gsk1210151a and Hypertension--Pulmonary

gsk1210151a has been researched along with Hypertension--Pulmonary* in 1 studies

Other Studies

1 other study(ies) available for gsk1210151a and Hypertension--Pulmonary

Article	Year
Inhibition of BET Proteins Reduces Right Ventricle Hypertrophy and Pulmonary Hypertension Resulting from Combined Hypoxia and Pulmonary Inflammation. International journal of molecular sciences, 2018, Jul-30, Volume: 19, Issue:8 Pulmonary hypertension is a co-morbidity, which strongly participates in morbi-mortality in patients with chronic obstructive pulmonary disease (COPD). Recent findings showed that bromodomain-containing proteins, in charge of reading histone acetylation, could be involved in pulmonary arterial hypertension. Our aim was to study the effect of I-BET151, an inhibitor of bromodomain and extra-terminal domain (BET), on the right ventricle hypertrophy and pulmonary hypertension, induced by a combination of chronic hypoxia and pulmonary inflammation, as the two main stimuli encountered in COPD. Adult Wistar male rats, exposed to chronic hypoxia plus pulmonary inflammation (CHPI), showed a significant right ventricle hypertrophy (+57%, Topics: Animals; Blood Pressure; Heterocyclic Compounds, 4 or More Rings; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Pneumonia; Pulmonary Disease, Chronic Obstructive; Rats, Wistar; Transcription Factors	2018

Article

Year

Inhibition of BET Proteins Reduces Right Ventricle Hypertrophy and Pulmonary Hypertension Resulting from Combined Hypoxia and Pulmonary Inflammation.

International journal of molecular sciences, 2018, Jul-30, Volume: 19, Issue:8

Pulmonary hypertension is a co-morbidity, which strongly participates in morbi-mortality in patients with chronic obstructive pulmonary disease (COPD). Recent findings showed that bromodomain-containing proteins, in charge of reading histone acetylation, could be involved in pulmonary arterial hypertension. Our aim was to study the effect of I-BET151, an inhibitor of bromodomain and extra-terminal domain (BET), on the right ventricle hypertrophy and pulmonary hypertension, induced by a combination of chronic hypoxia and pulmonary inflammation, as the two main stimuli encountered in COPD. Adult Wistar male rats, exposed to chronic hypoxia plus pulmonary inflammation (CHPI), showed a significant right ventricle hypertrophy (+57%,

Topics: Animals; Blood Pressure; Heterocyclic Compounds, 4 or More Rings; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Pneumonia; Pulmonary Disease, Chronic Obstructive; Rats, Wistar; Transcription Factors

2018