gsk1210151a has been researched along with Arthritis* in 1 studies
1 other study(ies) available for gsk1210151a and Arthritis
| Article | Year |
|---|---|
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression.
The functions of the bromodomain and extra terminal (BET) family of proteins have been implicated in a wide range of diseases, particularly in the oncology and immuno-inflammatory areas, and several inhibitors are under investigation in the clinic. To mitigate the risk of attrition of these compounds due to structurally related toxicity findings, additional molecules from distinct chemical series were required. Here we describe the structure- and property-based optimization of the Topics: Animals; Anti-Inflammatory Agents; Arthritis; Collagen; Crystallography, X-Ray; Dogs; Female; Imidazoles; Male; Mice; Molecular Structure; Nuclear Proteins; Protein Binding; Protein Domains; Quinolines; Rats, Inbred Lew; Rats, Wistar; Structure-Activity Relationship; Transcription Factors | 2021 |