gsk-j4 and Glioma
gsk-j4 has been researched along with Glioma* in 3 studies
Other Studies
3 other study(ies) available for gsk-j4 and Glioma
| Article | Year |
|---|---|
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.
Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG. Topics: Animals; Benzazepines; Brain Stem Neoplasms; Disease Models, Animal; Drug Synergism; Glioma; Humans; Hydroxamic Acids; Indoles; Panobinostat; Pyrimidines; Sequence Analysis, RNA; Xenograft Model Antitumor Assays | 2015 |
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.
Pediatric brainstem gliomas often harbor oncogenic K27M mutation of histone H3.3. Here we show that GSKJ4 pharmacologic inhibition of K27 demethylase JMJD3 increases cellular H3K27 methylation in K27M tumor cells and demonstrate potent antitumor activity both in vitro against K27M cells and in vivo against K27M xenografts. Our results demonstrate that increasing H3K27 methylation by inhibiting K27 demethylase is a valid therapeutic strategy for treating K27M-expressing brainstem glioma. Topics: Animals; Apoptosis; Benzazepines; Brain Stem Neoplasms; Cell Line, Tumor; Cell Proliferation; Child; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Mice; Pyrimidines; Xenograft Model Antitumor Assays | 2014 |
An epigenetic therapy for diffuse intrinsic pontine gliomas.
Diffuse intrinsic pontine glioma is a uniformly lethal malignant tumor of infancy with no effective therapies. A new study reveals that inhibition of JMJD3 has robust antitumor activity in diffuse intrinsic pontine glioma xenografts. Topics: Animals; Apoptosis; Benzazepines; Brain Stem Neoplasms; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Pyrimidines | 2014 |